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Vaccination

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Evaluating The Efficiency Of Public Policy Measures Against Covid-19, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş Jan 2021

Evaluating The Efficiency Of Public Policy Measures Against Covid-19, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş

Turkish Journal of Medical Sciences

The World Health Organization (WHO) declared COVID-19 as a Public Health Emergency of international concern on January 30, 2020, and a pandemic on March 11, 2020. Afterward, it spread rapidly all over the world, causing almost 4 million deaths as of June 2021. It is clear that effective preventive measures are needed in this devastating disease, which still has no cure. In addition to mask using, social distancing, and hygiene practices, which enter our lives as the most basic precautions, communities aim to reduce the effects of the COVID-19 pandemic. All over the world, the measures taken and activities performed …


Privacy In Pandemic: Law, Technology, And Public Health In The Covid-19 Crisis, Tiffany C. Li Jan 2021

Privacy In Pandemic: Law, Technology, And Public Health In The Covid-19 Crisis, Tiffany C. Li

Law Faculty Scholarship

The COVID-19 pandemic has caused millions of deaths and disastrous consequences around the world, with lasting repercussions for every field of law, including privacy and technology. The unique characteristics of this pandemic have precipitated an increase in use of new technologies, including remote communications platforms, healthcare robots, and medical Al. Public and private actors alike are using new technologies, like heat sensing, and technologically influenced programs, like contact tracing, leading to a rise in government and corporate surveillance in sectors like healthcare, employment, education, and commerce. Advocates have raised the alarm for privacy and civil liberties violations, but the emergency …


Risk Factors Associated With Childhood Vaccination Coverage In Afghanistan, Iqbal Mawani Jan 2021

Risk Factors Associated With Childhood Vaccination Coverage In Afghanistan, Iqbal Mawani

Walden Dissertations and Doctoral Studies

Globally, vaccination is among the most successful and cost-effective public health practices in the prevention of infectious diseases. The purpose of this study was to examine the child, parental, and geographical risk factors that influence childhood vaccination coverage in Afghanistan. The health belief model and socio-ecological model was used in this study as the theoretical framework to examine the effects of these risk factors on vaccination coverage among children in Afghanistan. Univariate, bivariate, and multivariate tests were conducted within the secondary data analysis of the 2015 Afghanistan national Demographic and Health Survey dataset. Of the 32,420 children aged 0 to …


Examining The Dunning-Kruger Effect In Autism Knowledge, Information Sourcing, And Endorsement Of Vaccination Policy, Alexandra Reed Jan 2021

Examining The Dunning-Kruger Effect In Autism Knowledge, Information Sourcing, And Endorsement Of Vaccination Policy, Alexandra Reed

PCOM Psychology Dissertations

The purpose of this study was to further examine the Dunning-Kruger effect as it relates to knowledge of autism, source of information, and endorsement of vaccination policy. Specifically, the study assessed the relationship between confidence in autism awareness and the belief that vaccines cause autism. It also examined the relationship between the source of information regarding autism and vaccines and vaccination attitudes. Last, it assessed whether individuals with higher confidence levels in the internet would be more likely to have both anti-vaccination attitudes and lower awareness of autism facts. Adult participants (N = 199) were surveyed on various social media …


Evaluation Of A Clinical Decision Support Strategy To Increase Seasonal Influenza Vaccination Among Hospitalized Children Before Inpatient Discharge, Evan W. Orenstein, Omar Elsayed-Ali, Swaminathan Kandaswamy, Erin Masterson, Reena Blanco, Pareen Shah, Patricia Lantis, Amy Kolwaite, Thomas E. Dawson, Edwin Ray, Christy Bryant, Srikant Iyer, Andi L. Shane, Stephanie Jernigan Jan 2021

Evaluation Of A Clinical Decision Support Strategy To Increase Seasonal Influenza Vaccination Among Hospitalized Children Before Inpatient Discharge, Evan W. Orenstein, Omar Elsayed-Ali, Swaminathan Kandaswamy, Erin Masterson, Reena Blanco, Pareen Shah, Patricia Lantis, Amy Kolwaite, Thomas E. Dawson, Edwin Ray, Christy Bryant, Srikant Iyer, Andi L. Shane, Stephanie Jernigan

Open Access Publications

Importance: Hospitalized children are at increased risk of influenza-related complications, yet influenza vaccine coverage remains low among this group. Evidence-based strategies about vaccination of vulnerable children during all health care visits are especially important during the COVID-19 pandemic.

Objective: To design and evaluate a clinical decision support (CDS) strategy to increase the proportion of eligible hospitalized children who receive a seasonal influenza vaccine prior to inpatient discharge.

Design, Setting, and Participants: This quality improvement study was conducted among children eligible for the seasonal influenza vaccine who were hospitalized in a tertiary pediatric health system providing care to more than half …


Lack Of Awareness Of Hepatitis B Screening And Vaccination In High-Risk Groups, Hati̇ce Yasemi̇n Balaban, Abdullah Tarik Aslan, Şefi̇ka Nur Ayar, Osman Dağ, Alpaslan Alp, Cem Şi̇mşek, Cavanşi̇r Vahabov, Tolga Yildirim, Hakan Göker, Yahya Büyükaşik, Hali̇s Şi̇mşek Jan 2021

Lack Of Awareness Of Hepatitis B Screening And Vaccination In High-Risk Groups, Hati̇ce Yasemi̇n Balaban, Abdullah Tarik Aslan, Şefi̇ka Nur Ayar, Osman Dağ, Alpaslan Alp, Cem Şi̇mşek, Cavanşi̇r Vahabov, Tolga Yildirim, Hakan Göker, Yahya Büyükaşik, Hali̇s Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: Hepatitis B virus (HBV) vaccination rates are insufficient in high-risk patients worldwide. This study aimed to investigate the screening, immunization, and vaccination rates in three high-risk groups for HBV infection: allogeneic hematopoietic stem cell transplantation (AHSCT), renal transplantation (RT), and chronic hepatitis C (CHC) groups. Materials and methods: The serological data of consecutive patients between 2014 and 2019 were reviewed using the hospital database. Results: The HBV screening rates were 100.0%, 90.4%, and 82.4% in the AHSCT, CHC, and RT groups, respectively (p = 0.003). The immunization rates against HBV through either previous exposure or vaccination were 79.5%, 71.7%, …


Influenza And Pneumococcus Vaccination Rates In Pediatric Dialysis Patients Ineurope: Recommendations Vs Realitya European Pediatric Dialysis Working Group And European Society For Pediatricnephrology Dialysis Working Group Study, Yeşi̇m Özdemi̇r Ati̇kel, Sevcan Azi̇me Bakkaloğlu Ezgü, Fabio Paglialonga, Constantinos J. Stefanidis, Varvara Askiti, Enrico Vidal, Gema Ariceta, Engi̇n Melek, Enrico Verrina, Nikoleta Printza, Karel Vondrak, Aleksandra Zurowska, Ilona Zagozdzon, Mesi̇ha Eki̇m, Eli̇f Nursel Özmert Jan 2021

Influenza And Pneumococcus Vaccination Rates In Pediatric Dialysis Patients Ineurope: Recommendations Vs Realitya European Pediatric Dialysis Working Group And European Society For Pediatricnephrology Dialysis Working Group Study, Yeşi̇m Özdemi̇r Ati̇kel, Sevcan Azi̇me Bakkaloğlu Ezgü, Fabio Paglialonga, Constantinos J. Stefanidis, Varvara Askiti, Enrico Vidal, Gema Ariceta, Engi̇n Melek, Enrico Verrina, Nikoleta Printza, Karel Vondrak, Aleksandra Zurowska, Ilona Zagozdzon, Mesi̇ha Eki̇m, Eli̇f Nursel Özmert

Turkish Journal of Medical Sciences

Background/aim: Children on dialysis are under increased risk of influenza and invasive pneumococcal disease. Although vaccination against these microorganisms are recommended in dialysis patients and despite the fact that these vaccines can reduce disease burden and rates of hospitalization due to infection, vaccination rates are below expected and desired. We aimed to evaluate influenza and pneumococcal vaccination and infection rates in European pediatric dialysis centers. Materials and methods: In 16 centers from 11 countries, 357 pediatric dialysis patients were evaluated retrospectively during 1 year of observation period between 01.01.2014 and 01.01.2015. Results: In all centers, vaccination policy included immunization of …


Balancing Public Health And Privacy: Lessons From Digital Contact Tracing For Covid-19 Vaccination Tracking Efforts, Carmel Shachar Jan 2021

Balancing Public Health And Privacy: Lessons From Digital Contact Tracing For Covid-19 Vaccination Tracking Efforts, Carmel Shachar

Saint Louis University Law Journal

The COVID-19 pandemic has brough the tension between individual privacy and public health initiative to the fore, in part because many of the solutions to the challenges of the pandemic proposed are digital. The first year of the pandemic has revealed that the Health Insurance Portability and Accountability Act is both too restrictive of traditional public health activities but also underprotective of important categories of health data. The failure of digital contact tracing applications to make a difference in combatting the pandemic during its early stages also illustrates the tension between individual privacy and public health surveillance. In order to …


Pseudomonas Aeruginosa Vaccine Development Using Dual-Species Whole Cell And Subunit Vaccines, Catherine Bell Blackwood Jan 2021

Pseudomonas Aeruginosa Vaccine Development Using Dual-Species Whole Cell And Subunit Vaccines, Catherine Bell Blackwood

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen which can cause severe, recurrent, and chronic infections. The pathogen is highly adaptable, and pneumonia caused by it is associated with high morbidity and mortality, especially in individuals with the genetic disorder cystic fibrosis. Antibiotic resistance amongst clinical isolates of P. aeruginosa is steadily increasing, and multi-drug resistant strains are prevalent. There is currently no vaccine available for commercial use against P. aeruginosa. For these reasons, we sought to understand the immunity to P. aeruginosa induced by whole cell vaccination and identify antigens for development of future subunit vaccines. In this dissertation, …


Sociodemographic Factors Associated With Childhood Vaccination Status In Sokoto State, Nigeria, Dauda Milgwe Madubu Jan 2021

Sociodemographic Factors Associated With Childhood Vaccination Status In Sokoto State, Nigeria, Dauda Milgwe Madubu

Walden Dissertations and Doctoral Studies

Immunization remains one of the most successful and cost-effective public health interventions worldwide. Despite the critical role of vaccines in improving childhood and maternal health, Sokoto state recorded the lowest childhood vaccination completion rate among the 37 states in Nigeria with only 5% of children aged 12-23 months having had full childhood vaccination based on data from the 2018 demographic and health survey. The factors associated with the state’s low childhood vaccination status have not been explored. The study examined the relationship between the sociodemographic factors including parents’ socioeconomic and ethnoreligious factors, place of residence, and children’s biological characteristics and …


The Effect Of The Covid-19 Vaccine On Daily Cases And Deaths Based On Global Vaccine Data, Zhiwei Li, Xiangtong Liu, Mengyang Liu, Zhiyuan Wu, Yue Liu, Weiming Li, Mengmeng Liu, Xiaonan Wang, Bo Gao, Yanxia Luo, Xia Li, Lixin Tao, Wei Wang, Xiuhua Guo Jan 2021

The Effect Of The Covid-19 Vaccine On Daily Cases And Deaths Based On Global Vaccine Data, Zhiwei Li, Xiangtong Liu, Mengyang Liu, Zhiyuan Wu, Yue Liu, Weiming Li, Mengmeng Liu, Xiaonan Wang, Bo Gao, Yanxia Luo, Xia Li, Lixin Tao, Wei Wang, Xiuhua Guo

Research outputs 2014 to 2021

Background: Coronavirus disease 2019 (COVID-19), a global pandemic, has caused over 216 million cases and 4.50 million deaths as of 30 August 2021. Vaccines can be regarded as one of the most powerful weapons to eliminate the pandemic, but the impact of vaccines on daily COVID-19 cases and deaths by country is unclear. This study aimed to investigate the correlation between vaccines and daily newly confirmed cases and deaths of COVID-19 in each country worldwide. Methods: Daily data on firstly vaccinated people, fully vaccinated people, new cases and new deaths of COVID-19 were collected from 187 countries. First, we used …


Conversational Ontology Operator: Patient-Centric Vaccine Dialogue Management Engine For Spoken Conversational Agents, Muhammad Amith, Rebecca Z Lin, Licong Cui, Dennis Wang, Anna Zhu, Grace Xiong, Hua Xu, Kirk Roberts, Cui Tao Dec 2020

Conversational Ontology Operator: Patient-Centric Vaccine Dialogue Management Engine For Spoken Conversational Agents, Muhammad Amith, Rebecca Z Lin, Licong Cui, Dennis Wang, Anna Zhu, Grace Xiong, Hua Xu, Kirk Roberts, Cui Tao

2020-Current year OA Pubs

BACKGROUND: Previously, we introduced our Patient Health Information Dialogue Ontology (PHIDO) that manages the dialogue and contextual information of the session between an agent and a health consumer. In this study, we take the next step and introduce the Conversational Ontology Operator (COO), the software engine harnessing PHIDO. We also developed a question-answering subsystem called Frankenstein Ontology Question-Answering for User-centric Systems (FOQUS) to support the dialogue interaction.

METHODS: We tested both the dialogue engine and the question-answering system using application-based competency questions and questions furnished from our previous Wizard of OZ simulation trials.

RESULTS: Our results revealed that the dialogue …


Hpv Vaccination In Adults 18 Through 45: Reducing Missed Vaccination Opportunities In The Primary Care Setting, Ashley Hernandez Dec 2020

Hpv Vaccination In Adults 18 Through 45: Reducing Missed Vaccination Opportunities In The Primary Care Setting, Ashley Hernandez

Doctor of Nursing Practice

HPV is the most prevalent sexually transmitted infection in the United States and is linked to six different types of cancer cell development. Prevention of infection from this virus could save hundreds of thousands of lives worldwide. An evidence-based quality improvement project was designed to increase the identification of HPV vaccination opportunities in the adult primary care setting to improve HPV vaccination rates. A protocol and patient eligibility algorithm were developed to align primary care practice with recently updated CDC guidelines. Interventions included clinic staff and provider education, designation of a vaccination champion, a flag within the patient chart to …


Bifurcation Analysis Of Newcastle Disease Eco-Epidemiological Model In The Presence Of Vaccination: A Case Of The Backyard Chicken, Furaha M. Chuma, Gasper G. Mwanga Nov 2020

Bifurcation Analysis Of Newcastle Disease Eco-Epidemiological Model In The Presence Of Vaccination: A Case Of The Backyard Chicken, Furaha M. Chuma, Gasper G. Mwanga

Journal of Humanities and Social Sciences

Journal of Education, Humanities and Sciences, Volume 9 No. 2, 2020: 42–59 © Dar es Salaam University College of Education (DUCE), 2020 Bifurcation Analysis of Newcastle Disease Eco-epidemiological Model in the Presence of Vaccination: A Case of the Backyard Chicken Furaha M. Chuma Dar es Salaam University College of Education University of Dar es Salaam [email protected] Gasper G. Mwanga Dar es Salaam University College of Education University of Dar es Salaam [email protected] Abstract Newcastle is an infectious disease caused by the avian paramyxomovirus-1. It occurs most frequently as a disease of Avians (e.g., chicken, ducks, pigeons, guinea fowls and other …


Increasing Hpv Vaccination In A Network Of Pediatric Clinics Using A Multi-Component Approach, Sally W. Vernon, Lara S. Savas, Ross Shegog, C. Mary Healy, Erica L. Frost, Sharon P. Coan, Efrat K. Gabay, Sharice M. Preston, Claire A. Crawford, Stanley W. Spinner, Matthew A. Wilber Nov 2020

Increasing Hpv Vaccination In A Network Of Pediatric Clinics Using A Multi-Component Approach, Sally W. Vernon, Lara S. Savas, Ross Shegog, C. Mary Healy, Erica L. Frost, Sharon P. Coan, Efrat K. Gabay, Sharice M. Preston, Claire A. Crawford, Stanley W. Spinner, Matthew A. Wilber

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: Despite continued public health efforts to increase human papillomavirus (HPV) vaccination among adolescents, initiation remains below the level needed to reach the Healthy People 2020 goal of 80% series completion by age 13.

Methods: We developed, implemented, and evaluated a multi-component program that used evidence-based strategies to increase HPV vaccine initiation in a network of 51 pediatric clinics in Houston, Texas. Our target populations were the clinic network, healthcare providers, male and female patients ages 11-17, and their parents. The program, called the Adolescent Vaccination Program (AVP), was conducted from March 2016 through March 2019 and contained strategies to …


Modeling And Controlling Epidemic Outbreaks: The Role Of Population Size, Model Heterogeneity And Fast Response In The Case Of Measles, Kezban Yagci Sokat, Benjamin Armbruster Nov 2020

Modeling And Controlling Epidemic Outbreaks: The Role Of Population Size, Model Heterogeneity And Fast Response In The Case Of Measles, Kezban Yagci Sokat, Benjamin Armbruster

Faculty Research, Scholarly, and Creative Activity

Modelers typically use detailed simulation models and vary the fraction vaccinated to study outbreak control. However, there is currently no guidance for modelers on how much detail (i.e., heterogeneity) is necessary and how large a population to simulate. We provide theoretical and numerical guidance for those decisions and also analyze the benefit of a faster public health response through a stochastic simulation model in the case of measles in the United States. Theoretically, we prove that the outbreak size converges as the simulation population increases and that the outbreaks are slightly larger with a heterogeneous community structure. We find that …


Comparing Intervention Strategies For Reducing Clostridioides Difficile Transmission In Acute Healthcare Settings: An Agent-Based Modeling Study, Brittany Stephenson, Cristina Lanzas, Suzanne Lenhart, Eduardo Ponce, Jason Bintz, Erik R Dubberke, Judy Day Oct 2020

Comparing Intervention Strategies For Reducing Clostridioides Difficile Transmission In Acute Healthcare Settings: An Agent-Based Modeling Study, Brittany Stephenson, Cristina Lanzas, Suzanne Lenhart, Eduardo Ponce, Jason Bintz, Erik R Dubberke, Judy Day

2020-Current year OA Pubs

BACKGROUND: Clostridioides difficile infection (CDI) is one of the most common healthcare infections. Common strategies aiming at controlling CDI include antibiotic stewardship, environmental decontamination, and improved hand hygiene and contact precautions. Mathematical models provide a framework to evaluate control strategies. Our objective is to evaluate the effectiveness of control strategies in decreasing C. difficile colonization and infection using an agent-based model in an acute healthcare setting.

METHODS: We developed an agent-based model that simulates the transmission of C. difficile in medical wards. This model explicitly incorporates healthcare workers (HCWs) as vectors of transmission, tracks individual patient antibiotic histories, incorporates varying …


Is It Lawful And Ethical To Prioritize Racial Minorities For Covid-19 Vaccines?, Harald Schmidt, Lawrence O. Gostin, Michelle A. Williams Oct 2020

Is It Lawful And Ethical To Prioritize Racial Minorities For Covid-19 Vaccines?, Harald Schmidt, Lawrence O. Gostin, Michelle A. Williams

Georgetown Law Faculty Publications and Other Works

Coronavirus disease 2019 (COVID-19) has disproportionately affected racial minorities in the United States resulting in higher rates of infection, hospitalization, and death. With a limited supply after the initial approval of a safe and effective vaccine, difficult legal and ethical choices will have to be made on priority access for individuals. The National Academies of Sciences, Engineering, and Medicine (NASEM) has recommended prioritization of racial minorities who are “worse off” socioeconomically and epidemiologically. TheWorld Health Organization (WHO) similarly cautioned that “colorblind” allocation frameworks could perpetuate or exacerbate existing injustices. Both NASEM and WHO urge policy makers to allocate vaccines in …


Examining Parental Perceptions And Decisions To Uptake Child Influenza Immunizations: Assessing Pandemic And Policy Impacts On Vaccination Rates Following The H1n1 Pandemic, And The Acip Laiv Preferential Recommendation Revocation, Amir H. Mehrabi Oct 2020

Examining Parental Perceptions And Decisions To Uptake Child Influenza Immunizations: Assessing Pandemic And Policy Impacts On Vaccination Rates Following The H1n1 Pandemic, And The Acip Laiv Preferential Recommendation Revocation, Amir H. Mehrabi

Theses and Dissertations

Introduction

2009 H1N1 Pandemic: The historical 2009 H1N1 Influenza pandemic, which had a CDC estimated accrued disease burden of 100.5 million illnesses, 936,000 hospitalizations, and 75,000 deaths from 2009 to 2018, resulted in a declared state of emergency nationally, with ensuing diminished vaccine confidence and amplified fears of infection, prompting some to pursue flu vaccination, and others to forego. Although the Centers for Disease Control and Prevention (CDC), and its Advisory Committee on Immunization Practices (ACIP) recommend an annual flu vaccine for individuals 6 months of age and older as the “first and best” defense against influenza, a low percentage …


Prevalence Of And Sociodemographic Disparities In Influenza Vaccination Among Adults With Diabetes In The United States, Priyanka Bhugra, Reed Mszar, Javier Valero-Elizond, Gowtham R. Grandhi, Salim S. Virani, Miguel Cainzos-Achirica, Farhaan S. Vahidy, Saad Omer, Khurram Nasir Sep 2020

Prevalence Of And Sociodemographic Disparities In Influenza Vaccination Among Adults With Diabetes In The United States, Priyanka Bhugra, Reed Mszar, Javier Valero-Elizond, Gowtham R. Grandhi, Salim S. Virani, Miguel Cainzos-Achirica, Farhaan S. Vahidy, Saad Omer, Khurram Nasir

Office of the Provost

National estimates describing the overall prevalence of and disparities in influenza vaccination among patients with diabetes mellitus (DM) in United States are not well described. Therefore, we analyzed the prevalence of influenza vaccination among adults with DM, overall and by sociodemographic characteristics, using the Medical Expenditure Panel Survey database from 2008 to 2016. Associations between sociodemographic factors and lack of vaccination were examined using adjusted logistic regression. Among adults with DM, 36% lacked influenza vaccination. Independent predictors of lacking influenza vaccination included age 18 to 39 years (odds ratio [OR] 2.54; 95% confidence interval [CI], 2.14-3.00), Black race/ethnicity (OR 1.29; …


Interventions In Measles Outbreaks: The Potential Reduction In Cases Associated With School Suspension And Vaccination Interventions, David R. Sinclair, John J. Grefenstette, Mary G. Krauland, David D. Galloway, Robert J. Frankeny, Clayton Travis, Donald S. Burke, Steven M. Albert, Mark S. Roberts Sep 2020

Interventions In Measles Outbreaks: The Potential Reduction In Cases Associated With School Suspension And Vaccination Interventions, David R. Sinclair, John J. Grefenstette, Mary G. Krauland, David D. Galloway, Robert J. Frankeny, Clayton Travis, Donald S. Burke, Steven M. Albert, Mark S. Roberts

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: Measles is resurgent in the US, with more cases in 2019 than any year since 1992. Many of the cases were concentrated in three outbreaks in New York and Washington states, where local governments enacted intervention strategies in an attempt to limit the spread of measles. Regulations differed by location, suggesting guidance on the optimal interventions may be beneficial.

Methods: We simulate the daily interactions of the populations of six metropolitan areas of Texas, US, using an agent-based model. The real-life vaccination rates of each school in these metropolitan areas are applied to simulated equivalents. A single case of …


Safety, Tolerability, And Immunogenicity Of Plasmodium Falciparum Sporozoite Vaccine Administered By Direct Venous Inoculation To Infants And Young Children: Findings From An Age De-Escalation, Dose-Escalation, Double-Blind, Randomized Controlled Study In Western Kenya, Laura C Steinhardt, Ginnie Abarbanell, Et Al. Aug 2020

Safety, Tolerability, And Immunogenicity Of Plasmodium Falciparum Sporozoite Vaccine Administered By Direct Venous Inoculation To Infants And Young Children: Findings From An Age De-Escalation, Dose-Escalation, Double-Blind, Randomized Controlled Study In Western Kenya, Laura C Steinhardt, Ginnie Abarbanell, Et Al.

2020-Current year OA Pubs

BACKGROUND: The whole Plasmodium falciparum sporozoite (PfSPZ) vaccine is being evaluated for malaria prevention. The vaccine is administered intravenously for maximal efficacy. Direct venous inoculation (DVI) with PfSPZ vaccine has been safe, tolerable, and feasible in adults, but safety data for children and infants are limited.

METHODS: We conducted an age de-escalation, dose-escalation randomized controlled trial in Siaya County, western Kenya. Children and infants (aged 5-9 years, 13-59 months, and 5-12 months) were enrolled into 13 age-dose cohorts of 12 participants and randomized 2:1 to vaccine or normal saline placebo in escalating doses: 1.35 × 105, 2.7 × 105, 4.5 …


Chimeric Ad5.F35 Vector Evades Anti-Adenovirus Serotype 5 Neutralization Opposing Gucy2c-Targeted Antitumor Immunity, John C. Flickinger, Jagmohan Singh, Robert D Carlson, Elinor Leong, Trevor R. Baybutt, Joshua Barton, Ellen M. Caparosa, Amanda M. Pattison, Jeff A. Rappaport, Jamin Roh, Tingting Zhan, Babar Bashir, Scott A Waldman, Adam E. Snook Aug 2020

Chimeric Ad5.F35 Vector Evades Anti-Adenovirus Serotype 5 Neutralization Opposing Gucy2c-Targeted Antitumor Immunity, John C. Flickinger, Jagmohan Singh, Robert D Carlson, Elinor Leong, Trevor R. Baybutt, Joshua Barton, Ellen M. Caparosa, Amanda M. Pattison, Jeff A. Rappaport, Jamin Roh, Tingting Zhan, Babar Bashir, Scott A Waldman, Adam E. Snook

Department of Pharmacology and Experimental Therapeutics Faculty Papers

BACKGROUND: Adenovirus serotype 5 (Ad5) is a commonly used viral vector for transient delivery of transgenes, primarily for vaccination against pathogen and tumor antigens. However, endemic infections with Ad5 produce virus-specific neutralizing antibodies (NAbs) that limit transgene delivery and constrain target-directed immunity following exposure to Ad5-based vaccines. Indeed, clinical trials have revealed the limitations that virus-specific NAbs impose on the efficacy of Ad5-based vaccines. In that context, the emerging focus on immunological approaches targeting cancer self-antigens or neoepitopes underscores the unmet therapeutic need for more efficacious vaccine vectors.

METHODS: Here, we evaluated the ability of a chimeric adenoviral vector (Ad5.F35) …


Edwardsiella Ictaluri Is Capable Of Persisting In Channel Catfish By Evading Host T Cell And Cell Death Responses, Elizabeth Watts Griggs Jul 2020

Edwardsiella Ictaluri Is Capable Of Persisting In Channel Catfish By Evading Host T Cell And Cell Death Responses, Elizabeth Watts Griggs

LSU Doctoral Dissertations

Edwardsiella ictaluri is a gram-negative bacterium of the family Enterobacteriaceae that infects and causes enteric septicemia (ESC) of channel catfish (Ictalurus punctatus), a fatal disease costing the catfish industry millions of dollars in losses each year. Edwardsiella. ictaluri is capable of replicating in catfish head-kidney-derived-macrophages (HKDM), and like many other gram-negative bacteria, E. ictaluri encodes a Type III Secretion System (T3SS) that is required for virulence and intracellular replication. In the case of E. ictaluri, the T3SS translocates effectors from the Edwardsiella containing vacuole (ECV) through the bacterial cell wall and the vacuolar membrane directly to the …


Taking The Politics Out Of Vaccines: Increasing Vaccination Rates Without Repealing Exemptions, Kylie A. Thompson Jun 2020

Taking The Politics Out Of Vaccines: Increasing Vaccination Rates Without Repealing Exemptions, Kylie A. Thompson

Saint Louis University Journal of Health Law & Policy

Vaccinations have become a vital part of disease prevention and public health; however, they remain a controversial topic in our society today. Non-medical exemptions to mandatory vaccination laws are the core of most of the controversy surrounding vaccinations. This Comment examines the controversy surrounding vaccinations and proposes interventions communities can adopt to increase vaccination rates without repealing non-medical exemptions to mandatory vaccination laws.


Effectiveness Of A Health Education Intervention About Influenza And Vaccine In Secondary Schools In South Lebanon, Israa Assaf, Salim Moussa Jun 2020

Effectiveness Of A Health Education Intervention About Influenza And Vaccine In Secondary Schools In South Lebanon, Israa Assaf, Salim Moussa

BAU Journal - Health and Wellbeing

Seasonal influenza is an intense respiratory illness caused by influenza viruses that circulate all around the world. In Lebanon, there is a lack of national flu awareness campaigns. Schools’ students are truly outstanding and viable sources to spread the awareness and strive for the conduct change in the general population. Hence, this study was carried out to test the effectiveness of a health education intervention in improving the knowledge, attitudes, and practices (KAP) toward influenza and its vaccine among secondary schools’ students in South Lebanon. This is a Pre/Post research study conducted in four schools located in South Lebanon. A …


Impacts Of Rift Valley Fever Virus: A One Health Approach To Assess Burden And Inform Prevention And Control Options, Catherine Machalaba Jun 2020

Impacts Of Rift Valley Fever Virus: A One Health Approach To Assess Burden And Inform Prevention And Control Options, Catherine Machalaba

Dissertations and Theses

Background: Rift Valley Fever (RVF) is a climate-sensitive emerging zoonotic disease associated with large-scale livestock production losses and human disease burden in Sub-Saharan Africa and the Middle East. While recognized as a key One Health issue based on its transmission dynamics involving human, animal and environmental determinants, there has been poor coordination between sectors to reduce the risk and impact of RVF. Efforts to counter the disease remain largely reactive, presenting an ongoing threat to local and global health security. The intent of this dissertation was to improve understanding of the burden of RVF across society and to identify entry …


Increasing Knowledge About Hpv And The Hpv Vaccine Amongst College Students, Morgan Baxter May 2020

Increasing Knowledge About Hpv And The Hpv Vaccine Amongst College Students, Morgan Baxter

Doctor of Nursing Practice Scholarly Project

This scholarly project included an education presentation to Pittsburg State University students enrolled in the Health Promotion class in the Fall of 2019, a pretest was taken before the educational presentation and then a posttest was completed to assess the student’s knowledge of HPV and the HPV vaccine. The posttest evaluated whether there was an increase in knowledge after the presentation. In this scholarly project there was an overall increase in knowledge with statistical significance (p


Lessons From The Front Line: Advocating For Vaccine Policies At The Texas Capitol During Turbulent Times, Rekha Lakshmanan, Mha, Jason Sabo, Ma May 2020

Lessons From The Front Line: Advocating For Vaccine Policies At The Texas Capitol During Turbulent Times, Rekha Lakshmanan, Mha, Jason Sabo, Ma

Journal of Applied Research on Children: Informing Policy for Children at Risk

In 2003, anti-vaccine activists successfully advocated to change Texas law to make it easier for parents to send their children to public school without school required vaccinations. Over fifteen years ago, 2,314 non medical exemptions were filed. The Texas Department of State Health Services recently reported in the 2018-19 school year, 64,176 exemptions were submitted. As the number of non-medical exemptions increase, the risk for a vaccine preventable outbreak also increases.

Enacting strong immunization laws and policies, which includes improving access to vaccination, increasing education, and enhancing data collection, is cyclical. In the past ten years, over 17 pieces of …


Studying Public Perception About Vaccination: A Sentiment Analysis Of Tweets, Viju Raghupathi, Jie Ren, Wullianallur Raghupathi May 2020

Studying Public Perception About Vaccination: A Sentiment Analysis Of Tweets, Viju Raghupathi, Jie Ren, Wullianallur Raghupathi

Publications and Research

Text analysis has been used by scholars to research attitudes toward vaccination and is particularly timely due to the rise of medical misinformation via social media. This study uses a sample of 9581 vaccine-related tweets in the period 1 January 2019 to 5 April 2019. The time period is of the essence because during this time, a measles outbreak was prevalent throughout the United States and a public debate was raging. Sentiment analysis is applied to the sample, clustering the data into topics using the term frequency–inverse document frequency (TF-IDF) technique. The analyses suggest that most (about 77%) of the …