Digital Commons Network^™

Antibody Responses To Sars-Cov-2 After Infection Or Vaccination In Children And Young Adults With Inflammatory Bowel Disease., Joelynn Dailey, Lina Kozhaya, Mikail Dogan, Dena Hopkins, Blaine Lapin, Katherine Herbst, Michael Brimacombe, Kristen Grandonico, Fatih Karabacak, John Schreiber, Bruce Tsan-Liang Liang, Juan C Salazar, Derya Unutmaz, Jeffrey S Hyams

Faculty Research 2022

BACKGROUND: Characterization of neutralization antibodies to SARS-CoV-2 infection or vaccination in children and young adults with inflammatory bowel disease (IBD) receiving biologic therapies is crucial.

METHODS: We performed a prospective longitudinal cohort study evaluating SARS-CoV-2 spike protein receptor binding domain (S-RBD) IgG positivity along with consistent clinical symptoms in patients with IBD receiving infliximab or vedolizumab. Serum was also obtained following immunization with approved vaccines. The IgG antibody to the spike protein binding domain of SARS-CoV-2 was assayed with a fluorescent bead-based immunoassay that takes advantage of the high dynamic range of fluorescent molecules using flow cytometry. A sensitive and …

Correlates Of Zero-Dose Vaccination Status Among Children Aged 12–59 Months In Sub-Saharan Africa: A Multilevel Analysis Of Individual And Contextual Factors, Chamberline E. Ozigbu, Bankole Olatosi Ph.D., Zhenlong Li, James W. Hardin, Nicole L. Hair

Faculty Publications

Despite ongoing efforts to improve childhood vaccination coverage, including in hard-to-reach and hard-to-vaccinate communities, many children in sub-Saharan Africa (SSA) remain unvaccinated. Considering recent goals set by the Immunization Agenda 2030 (IA2030), including reducing the number of zero-dose children by half, research that goes beyond coverage to identify populations and groups at greater risk of being unvaccinated is urgently needed. This is a pooled cross-sectional study of individual- and country-level data obtained from Demographic and Health Surveys Program and two open data repositories. The sample includes 43,131 children aged 12–59 months sampled between 2010 and 2020 in 33 SSA countries. …

Correlates Of Zero-Dose Vaccination Status Among Children Aged 12-59 Months In Sub-Saharan Africa: A Multilevel Analysis Of Individual And Contextual Factors, Chamberline Ozigbu, Bankole Olatosi, Zhenlong Li, James W. Hardin, Nicole L. Hair

Faculty Publications

Despite ongoing efforts to improve childhood vaccination coverage, including in hard-to-reach and hard-to-vaccinate communities, many children in sub-Saharan Africa (SSA) remain unvaccinated. Considering recent goals set by the Immunization Agenda 2030 (IA2030), including reducing the number of zero-dose children by half, research that goes beyond coverage to identify populations and groups at greater risk of being unvaccinated is urgently needed. This is a pooled cross-sectional study of individual- and country-level data obtained from Demographic and Health Surveys Program and two open data repositories. The sample includes 43,131 children aged 12–59 months sampled between 2010 and 2020 in 33 SSA countries. …

Attitudes Toward Covid-19 Vaccination Among Occupational Therapy Professionals And Students In Early 2021, Stephen A. Cage, Brandon J. Warner, Diana M. Gallegos, Heidi M. Cage, Diane P. Brown Phd, Otr

Internet Journal of Allied Health Sciences and Practice

Purpose: After the widespread transmission of the novel coronavirus that causes COVID-19, the first COVID-19 vaccination received emergency use authorization in the United States in December of 2020. Current research has shown the authorized COVID-19 vaccines to be safe and effective at preventing severe illness. At the time of this study, there appears to be no published research on the attitudes and receipt of COVID-19 vaccinations among occupational therapy professionals and students. The purpose of this study is to describe the attitudes and receipt of COVID-19 vaccinations among occupational therapy professionals and students in early 2021. Methods: A total of …

Factors Associated With Covid-19 Vaccine Intentions Among South Carolina Residents, Mufaro Kanyangarara, Lauren Mcabee, Virginie G. Daguise, Melissa Nolan Ph.D., Mph

Faculty Publications

Despite evidence of vaccine safety and efficacy, vaccine hesitancy remains a major global health threat. The COVID-19 vaccine has presented unique vaccine hesitancy concerns compared to parental vaccine hesitancy towards childhood vaccines. South Carolina (SC) is home to a largely conservative population and historically has some of the lowest vaccination coverage rates in the United States of America. The goal of the current study was to identify factors associated with COVID-19 vaccine intentions among SC residents. From November 2020 to September 2021, 300,000 invitations to participate in community testing and complete an online survey were mailed to randomly selected SC …

Improving Vaccination Rates Through Community Partnership, Marissa Marquez

Doctor of Nursing Practice Final Manuscripts

IMPROVING VACCINATION RATES THROUGH COMMUNITY PARTNERSHIP

by

Marissa Marquez, DNP Student, FNP-C, MSN, MBA, RN, BSN

Clinical Mentor: Jill Milton, MSN, FNP-C

Joseph Burkard, DNSc, CRNA, AACN Health Policy Fellow

Purpose: The purpose of the quality improvement project is to improve the vaccination rates and vaccine series completion rates of school age children at Rosa Parks Elementary school through a targeted educational intervention.

Background: Under immunization among school-aged children is an ongoing challenge. Low rates of immunization can cause outbreaks of communicable disease, leading to preventable injury, loss of life, and burden to the healthcare system. Among other …

Covid-“14-17”: A Case For Florida Teens To Choose The Covid Vaccine Without Requiring Parental Consent, Kait Ramsay

Child and Family Law Journal

The novel COVID-19 pandemic has created a huge disruption to almost everyone, forcing many individuals to adapt to entirely new ways of life. In the United States, COVID safety protocols and restrictions, such as mask and vaccine mandates, have been met with huge political polarization and resistance.[1] Even as COVID variants have kept infections in a perpetual cycle of rising and falling, Florida has lifted mask mandates for businesses and schools, and its governor has been one of the largest vocal opponents to requiring vaccines for school attendance.[2] Furthermore, with the passing of Florida’s Parental Consent for Health …

Cellular Automata: The Mathematical Theory Behind The Spread Of Covid-19 And Prediction Of Future Spread, Alison Drumheller

Undergraduate Theses and Capstone Projects

This thesis seeks to analyze the spread of the original COVID-19 strain and develop a mathematical model to predict the chances of being infected by this disease using a number of variables. This model is based on the mathematical theory of cellular automata, otherwise known as the theory of spread. The research uses real world data of COVID-19 which includes infection rate, death rate, vaccination rate, use of masks, and transmission rates. By using cellular automata, we predict that the more preventative measures an individual puts in place for themselves, the less likely they are to be infected by the …

Factors Influencing Vaccination Rates In Children Under Two In Southeast Kansas, Danielle Bennett

Doctor of Nursing Practice Scholarly Project

Introduction

A large Federally Qualified Health Center (FQHC) in Southeast Kansas has a 37% compliance of children completing the recommended combo 10 primary vaccination series before their second birthday. An additional 20% of children would be compliant if the flu vaccine was excluded, raising the compliance rate to 57%. This is still below the national average of 68-75%, leaving many children in Southeast Kansas and northeast Oklahoma unprotected from preventable childhood diseases.

Purpose

The purpose of this scholarly project was to identify barriers to vaccination, including vaccine hesitancy and socioeconomic barriers affecting completion of the primary vaccine series, or combo …

Rates And Perceptions Of Covid-19 Vaccination From University Of Mississippi Students, Josie Parham

Honors Theses

The trials, tribulations and triumphs of the global COVID-19 pandemic are impacted by and are a product of behaviors that occur at the level of nations, states, cities and, ultimately, communities. In the wake of the development of safe and effective vaccines against SARS-CoV2, the virus responsible for the pandemic, the significance of the vaccine is closely linked to the number of individuals that receive the vaccine. To date, surveys have measured sizable variations in vaccination rates between nations, states, cities, and communities. Focusing on events that have transpired in one such local community, the present study (i) measured the …

Covid-19, Vaccination, And Heart Transplantation, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Coercion Or Influence? Ethical Strategies Leaders Should Use To Increase Covid-19 Vaccination Uptake, Olivia Podber

Honors Theses

The COVID-19 pandemic, which has led to millions of cases and deaths around the world, persists, in large part, due to vaccine hesitancy. Through interrogating the harm principle and exploring ethical justifications of influence, this thesis seeks to determine justifiable strategies leaders should use to increase COVID-19 vaccination uptake. I will argue that lesser forms of coercion—such as vaccine mandates—are justifiable, in principle, but ought not to be used by agents due to concerns for liberty and trust, and the presence of less restrictive alternatives. Thus, leaders should use influence strategies to motivate behavior change from the vaccine hesitant.

Religious Freedom Vs. Compelled Vaccination: A Case-Study Of The 2018-2019 Measles Pandemic Or The Law As A Public Health Response, Barbara Pfeffer Billauer Esq.

Catholic University Law Review

Following the recent decision in Roman Catholic Diocese v. Cuomo,^[1] clear guidance regarding the state’s powers to act during a pandemic is wanting. I look here to the 2018–2019 global measles epidemic, with a focus on the New York and Israeli experiences, for that guidance. Measles rates increased dramatically during the 2018–2019 season, both in the United States and globally. This phenomenon reflects a general decline in worldwide vaccination and an increase in vaccine resistance stoked by anti-vax groups. In the United States, the epidemic targeted ultra-Orthodox Jewish communities, as it did in Israel. This Article evaluates the …

Are Antipyretic Medications Compatible With Sars-Cov-2 Vaccines?, Sharanya S E Santhi, Niguma Rayamajhi, Steven B Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

The Center Of Vaccine Controversy: Wi-38 Cells, Courtney S. Chau

Classical Conversations

Throughout history, there exists no bigger killer than disease. For centuries, families have fought against sickness and death, and ancient culture has spent thousands of years developing their own methods for healing. In the most recent years, the field of medicine has greatly expanded, allowing for cures and medicine to be greatly distributed to the general public. Millions of lives have been saved, and today society can live without fear of lurking diseases snatching away loved ones with a blink of an eye. This senior thesis focuses on the development of vaccines made from the WI-38 cell line. This cell …

Health Choice Or Health Coercion? The Osha Emergency Temporary Standard Covid-19 Vaccination Mandates: Ax Or Vax, Savannah Snyder

Helm's School of Government Conference - 2021-2024

No abstract provided.

Assessing Influenza Vaccination Coverage And Predictors In Persons Living With Hiv/Aids In Louisiana, June 2002-June 2013, Patrick Maloney, Ariane Rung, Stephanie Broyles, John Couk, Edward Peters, Susanne Straif-Bourgeois

Population and Public Health Science Faculty Publications

Background. Despite the burden of disease and increased risk of influenza-associated morbidity and mortality among PLWHA, influenza vaccination has been understudied in this population. Methods. We built an 11-year cohort of HIV-infected adults from medical records of PLWHA seeking care within the Louisiana State University medical system from June 2002-June 2013. Influenza vaccination uptake among PLWHA was calculated overall and for each medical facility for each influenza season. Linear regression was used to assess influenza vaccination uptake over time, both overall and by facility. Data were restricted to the final influenza season (2012-13) to assess predictors of PLWHA vaccination. Individuals …

Implementation Of A Drive-Through Covid-19 Mass Vaccination Site: Experiences From Louvax–Broadbent In Louisville, Kentucky, Ruth Carrico, Sarah Beth Hartlage, Valenchia Brown Msn, Aprn, Fnp-C, Sarah M. Bishop, Luanne Didelot, William Hayden, Beverly Williams Coleman, Sarah Tan, Delanor Manson, Kellie Kane, Dawn Balcom, Paul Kern

The University of Louisville Journal of Respiratory Infections

Background: Response to the COVID-19 pandemic has required innovative approaches to vaccination, including methods to rapidly and safely immunize communities. A major challenge to such a response involved access to untapped healthcare worker resources. The Louisville, Kentucky, response involved the use of a large volunteer workforce to supplement local public health employees in planning and implementing a large-scale drive-through vaccination event. The objective of this manuscript was to outline processes involved in training a mass immunization workforce and implementating a large-scale COVID-19 community vaccination.

Approach: Competency-based and standardized training was provided for every volunteer before working their shift. Volunteers worked …

Strict Lyapunov Functions And Feedback Controls For Sir Models With Quarantine And Vaccination, Hiroshi Ito, Michael Malisoff, Frederic Mazenc

Faculty Publications

We provide a new global strict Lyapunov function construction for a susceptible, infected, and recovered (or SIR) disease dynamics that includes quarantine of infected individuals and mass vaccination. We use the Lyapunov function to design feedback controls to asymptotically stabilize a desired endemic equilibrium, and to prove input-to-state stability for the dynamics with a suitable restriction on the disturbances. Our simulations illustrate the potential of our feedback controls to reduce peak levels of infected individuals.

Industry 4.0 Technologies For The Manufacturing And Distribution Of Covid-19 Vaccines, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Aminah Abdul Razzack, Shehar Bano, Sarabjot Singh Makkar, Sindhu Thevuthasan, Trissa Paul, Muhammad Khawar Sana, Nishwa Azeem

Department of Paediatrics and Child Health

Background: The evolutionary stages of manufacturing have led us to conceptualize the use of Industry 4.0 for COVID-19 (coronavirus disease 2019), powered by Industry 4.0 technologies. Using applications of integrated process optimizations reliant on digitized data, we propose novel intelligent networks along the vaccine value chain. Vaccine 4.0 may enable maintenance processes, streamline logistics, and enable optimal production of COVID-19 vaccines.
Vaccine 4.0 framework: The challenge in applying Vaccine 4.0 includes the requirement of large-scale technologies for digitally transforming manufacturing, producing, rolling-out, and distributing vaccines. With our framework, Vaccine 4.0 analytics will target process performance, process development, process stability, compliance, …

Factors That Determine Utilization Of The Canadian School-Based Human Papilloma Virus Vaccine Programs, Diane Gloria Brown

Walden Dissertations and Doctoral Studies

Human Papilloma Virus (HPV) is the most common sexually transmitted infection in the world and is the known causative agent of many HPV-associated cancers in both males and females. HPV vaccination rates in Canada are significantly lower than other developed countries and this finding is poorly understood as Canadian adolescents have access to free-of-charge HPV vaccines through school-based vaccination programs. This quantitative descriptive study used an online survey to collect data from 992 eligible respondents. This study identified predisposing, enabling, and need factors characterized by the Andersen behavioral model of health services use which facilitate or impede the use of …

An Agent-Centered Approach To Covid-19 Vaccinations, Nila Venkat

CMC Senior Theses

The rise of COVID-19 has dramatically affected the global economy, healthcare systems, and individuals’ daily lives. One of the most controversial attempts to ameliorate the effects of the virus in the United States has been the distribution of COVID-19 vaccinations. In this thesis, I propose a novel agent-centered approach to motivating COVID-19 vaccinations. I begin by exploring the origins and evolution of the virus, along with the growing demographic of “vaccine-hesitant” Americans, to contextualize the debate surrounding vaccinations. I then propose two potential action-based response strategies for vaccine motivation: a vaccine mandate and nudges. Concerning a mandate response strategy, I …

Risk Of Alzheimer's Disease Following Influenza Vaccination: A Claims-Based Cohort Study Using Propensity Score Matching, Avram S Bukhbinder, Yaobin Ling, Omar Hasan, Xiaoqian Jiang, Yejin Kim, Kamal N Phelps, Rosemarie E Schmandt, Albert Amran, Ryan Coburn, Srivathsan Ramesh, Qian Xiao, Paul E Schulz

Faculty, Staff and Student Publications

BACKGROUND: Prior studies have found a reduced risk of dementia of any etiology following influenza vaccination in selected populations, including veterans and patients with serious chronic health conditions. However, the effect of influenza vaccination on Alzheimer's disease (AD) risk in a general cohort of older US adults has not been characterized.

OBJECTIVE: To compare the risk of incident AD between patients with and without prior influenza vaccination in a large US claims database.

METHODS: Deidentified claims data spanning September 1, 2009 through August 31, 2019 were used. Eligible patients were free of dementia during the 6-year look-back period and≥65 years …

Pharmacy-Based Immunization Laws And Adolescent Well-Child Checkup Tradeoffs: Results From The Nis-Teen 2019, Teigan Avery

Graduate Student Theses, Dissertations, & Professional Papers

Pharmacy-based immunization (PBI) has been heralded as a barrier-reducing way to immunize Americans and reach public health targets. PBI programs vary by state; some states prohibit vaccinating children in pharmacies while others allow pharmacists to prescribe and immunize persons of any age. There is concern that liberal PBI programs may boost vaccination rates at the cost of well-child visits. Parents may see PBI as an alternative to preventive well-check visits at a doctor’s office rather than as a complement, particularly for adolescents. This paper estimates the effect of state vaccination policies on individual adolescent 11–12-year-old well-checks using probit regression for …

Exploring Vaccination Hesitancy Among Nonmandated Nurses And Health Care Workers, Germaine Lazett Nelson

Walden Dissertations and Doctoral Studies

COVID-19 vaccinations have been mandated for most healthcare professionals providing direct patient care, but there are a group of nonmandated healthcare professionals who have been hesitant to receive the vaccine. Given prolonged hesitancy among key health professionals charged with providing direct patient care, it is crucial to understand why they are hesitant; their apprehension may impact the pool of professionals available to provide direct patient care. This is a cross-sectional quantitative study that included an online survey. The health belief model served as the theoretical framework. The research questions addressed whether there is an association between type of patient care …

Parent And Healthcare Provider Beliefs About Chlamydia Adolescent Vaccine, Alison P. Footman

All ETDs from UAB

Introduction: Chlamydia is the most common bacterial sexually transmitted infection (STI) worldwide and it disproportionally affects young people and those living in the Southern United States. If left untreated chlamydia infections can lead to complications such as infertility and pelvic inflammatory disease. Currently, chlamydia vaccines are being development. A successful chlamydia immunization program would require adolescents to be vaccinated before engagement in sexual activity and would require parental approval and recommendations from healthcare providers. Therefore, this project aims to explore parent and healthcare provider opinions about chlamydia vaccines to identify potential barriers and facilitators to uptake. Because the COVID-19 pandemic …

Leveraging Moral Foundations To Increase Covid-19 Vaccination, Cara Elizabeth Ray

Dissertations

Despite the vast majority of the eligible U.S. adult population being vaccinated against COVID-19, geographical clusters of unvaccinated individuals pose a substantial risk of outbreak. It is important to encourage as many individuals as possible to vaccinate against COVID-19 to reduce its spread and severity. Past research has identified endorsement of the purity and liberty moral foundations – intuitive domains of moral concern – as predictors of vaccine hesitancy and political conservatism, while conservatism is itself associated with vaccine hesitancy. Across two online surveys, I examined the effects of a message invoking the purity and liberty foundations as well as …

Turkey's Transition To Face-To-Face Schooling During The Covid-19 Pandemic, Mahmut Özer, Hayri̇ Eren Suna, Matjaz Perc, Sadri̇ Şensoy, Sevi̇l Uygun İli̇khan

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 pandemic majorly disrupted conventional schooling and many countries maintained educational services through distance education. The duration of school closures in Turkey was longer than most OECD countries, thus Turkey prioritized school reopenings in the 2021-2022 academic year to mitigate possible negative outcomes of closures. Here we study the compatibility of implications for school reopenings in Turkey with these practices and assess the first semester of face-to-face schooling. Materials and methods: We have used document analysis to present and compare the practices in Turkey with international practices. We also used a comparative approach to assess the coherence between …

Why Do Parents Refuse Childhood Vaccination? Reasons Reported In Finland, Johanna Nurmi, Bronwyn Harman

Research outputs 2014 to 2021

Aims: This article examines the reasons for partial and complete refusal of childhood vaccination as reported by parents in Finland. It analyzes perceptions and experiences central in vaccination decisions. Methods: The analysis is based on 38 in-depth interviews with Finnish parents who have refused all or several vaccines for their children. The interviews were analyzed using qualitative content analysis. Results: Three categories of reasons were identified in the analysis: 1) risks and effects of vaccination – concern about and/or experiences of possible side-effects was the most important reason for avoiding vaccines; 2) distrust – participants did not trust vaccination recommendations …

Creation Of A Global Vaccine Risk Index, Tasmiah Nuzhath, Peter J Hotez, Ashish Damania, P Shuling Liu, Brian Colwell

Center for Medical Ethics and Health Policy Staff Publications

The World Health Organization has identified vaccine hesitancy as one of its top ten global health threats for 2019. Efforts are underway to define the factors responsible for reductions in vaccine confidence. However, as global measles cases accelerated beginning in 2018, it became evident that additional factors were promoting measles re-emergence, including war, political and socio-economic collapse, shifting poverty, and vulnerability to weather events and climate change. Accordingly, we propose a Global Vaccine Risk Index (VRI) to consider these variables as a more comprehensive means to identify vulnerable nations where we might expect measles and other vaccine-preventable diseases to emerge …