Digital Commons Network^™

Exploration Of A Potential Door Endpoint For Hospital-Acquired Bacterial Pneumonia And Ventilator-Associated Bacterial Pneumonia Using Six Registrational Trials For Antibacterial Drugs, Tori Kinamon, Ursula Waack, Mark Needles, Daniel Rubin, Deborah Collyar, Sarah B Doernberg, Scott R Evans, Toshimitsu Hamasaki, Thomas L Holland, Jessica Howard-Anderson, Henry Chambers, Vance G Fowler, Sumati Nambiar, Peter Kim, Helen W Boucher, Ramya Gopinath

Faculty, Staff and Student Publications

BACKGROUND: Desirability of outcome ranking (DOOR) is an innovative approach to clinical trial design and analysis that uses an ordinal ranking system to incorporate the overall risks and benefits of a therapeutic intervention into a single measurement. Here we derived and evaluated a disease-specific DOOR endpoint for registrational trials for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).

METHODS: Through comprehensive examination of data from nearly 4000 participants enrolled in six registrational trials for HABP/VABP submitted to the Food and Drug Administration (FDA) between 2005 and 2022, we derived and applied a HABP/VABP specific endpoint. We estimated the probability that …

A Randomized Controlled Trial Testing The Effects Of A Social Needs Navigation Intervention On Health Outcomes And Healthcare Utilization Among Medicaid Members With Type 2 Diabetes, Amy Mcqueen, David Von Nordheim, Charlene Caburnay, Linda Li, Cynthia Herrick, Lauren Grimes, Darrell Broussard, Rachel E Smith, Dana Lawson, Yan Yan, Matthew Kreuter

2020-Current year OA Pubs

Health systems are increasingly assessing and addressing social needs with referrals to community resources. The objective of this randomized controlled trial was to randomize adult Medicaid members with type 2 diabetes to receive usual care (

Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, And Cardiovascular Disease Risk In Us Hispanics And Latinos: Results From Hchs/Sol, Yi Wang, Guo-Chong Chen, Zheng Wang, Kai Luo, Yanbo Zhang, Yang Li, Amanda C Mcclain, Marta M Jankowska, Krista M Perreira, Josiemer Mattei, Carmen R Isasi, Maria M Llabre, Bharat Thyagarajan, Martha L Daviglus, Linda Van Horn, David Goldsztajn Farelo, Luis E Maldonado, Steven R Levine, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D Burk, Robert C Kaplan, Qibin Qi, Brandilyn A Peters

Faculty, Staff and Student Publications

Background: Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, and blood metabolites among US Hispanic and Latino adults.

Methods: In the HCHS/SOL (Hispanic Community Health Study/Study of Latinos), US exposure was defined by years in the United States (50 states and Washington, DC) and US nativity. A dietary acculturation pattern was derived from 14 172 participants with two 24-hour dietary recalls at baseline (2008-2011) using least absolute shrinkage and selection operator regression, with food groups as predictors of US …

Nrg Oncology And Particle Therapy Co-Operative Group Patterns Of Practice Survey And Consensus Recommendations On Pencil-Beam Scanning Proton Stereotactic Body Radiation Therapy And Hypofractionated Radiation Therapy For Thoracic Malignancies, Wei Liu, Hongying Feng, Paige A Taylor, Minglei Kang, Jiajian Shen, Jatinder Saini, Jun Zhou, Huan B Giap, Nathan Y Yu, Terence S Sio, Pranshu Mohindra, Joe Y Chang, Jeffrey D Bradley, Ying Xiao, Charles B Simone, Liyong Lin

Faculty, Staff and Student Publications

Stereotactic body radiation therapy (SBRT) and hypofractionation using pencil-beam scanning (PBS) proton therapy (PBSPT) is an attractive option for thoracic malignancies. Combining the advantages of target coverage conformity and critical organ sparing from both PBSPT and SBRT, this new delivery technique has great potential to improve the therapeutic ratio, particularly for tumors near critical organs. Safe and effective implementation of PBSPT SBRT/hypofractionation to treat thoracic malignancies is more challenging than the conventionally fractionated PBSPT because of concerns of amplified uncertainties at the larger dose per fraction. The NRG Oncology and Particle Therapy Cooperative Group Thoracic Subcommittee surveyed proton centers in …

A/B Testing Of User Enrollment Forms To Enhance Diversity In The Biomedical Workforce Via The National Research Mentoring Network: User-Centered Design Case Study, Toufeeq Ahmed Syed, Erika L Thompson, Jason Johnson, Zainab Latif, Nan Kennedy, Damaris Javier, Katie Stinson, Jamboor K Vishwanatha

Faculty, Staff and Student Publications

BACKGROUND: The National Research Mentoring Network (NRMN) is a National Institutes of Health-funded program for diversifying the science, technology, engineering, math, and medicine research workforce through the provision of mentoring, networking, and professional development resources. The NRMN provides mentoring resources to members through its online platform-MyNRMN.

OBJECTIVE: MyNRMN helps members build a network of mentors. Our goal was to expand enrollment and mentoring connections, especially among those who have been historically underrepresented in biomedical training and the biomedical workforce.

METHODS: To improve the ease of enrollment, we implemented the split testing of iterations of our user interface for platform registration. …

Vaccine-Sensitive Allocation - Another Divide To Divide Us?, Joelle Robertson-Preidler, Olivia Schuman

Faculty and Staff Publications

No abstract provided.

Multicountry Spread Of Influenza A(H1n1)Pdm09 Viruses With Reduced Oseltamivir Inhibition, May 2023-February 2024, Mira C Patel, Ha T Nguyen, Philippe Noriel Q Pascua, Rongyuan Gao, John Steel, Rebecca J Kondor, Larisa V Gubareva

Faculty, Staff and Student Publications

Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.

Black Radio’S Contribution To Collective And Cultural Memory: Personnel Perspectives Of Black Radio History In The United States, Kim Fox

Faculty Journal Articles

This interdisciplinary research investigates the significance of the community connection between Black radio personnel and their audiences through the lens of collective and cultural memory narratives. The study addresses two key research questions. First, how do Black radio personnel’s collective and cultural memories contribute to the Black public sphere? Second, what are the defining characteristics in developing parasocial relationships and interactions between Black radio personalities and their audiences? The qualitative research employs an autoethnographic methodology and a questionnaire, utilizing insights gained from the author’s experiences working at a Black-owned radio network and station. The questionnaire, distributed to key informants in …

Social Media And Dermatology During The Covid-19 Pandemic: Analyzing User-Submitted Posts Seeking Dermatologic Advice On Reddit, Vivek V Shukla, Benjamin A Carper, Namasivayam Ambalavanan, Matthew A Rysavy, Edward F Bell, Abhik Das, Ravi M Patel, Carl T D'Angio, Kristi L Watterberg, C Michael Cotten, Stephanie L Merhar, Myra H Wyckoff, Pablo J Sánchez, Neha Kumbhat, Waldemar A Carlo, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network

Faculty, Staff and Student Publications

HYPOTHESIS: Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period.

STUDY DESIGN: Prospective study at the NICHD Neonatal Research Network sites comparing EPLB (22

RESULTS: EPLB and EPIS percentages did not significantly decrease (1.58-1.45%, p = 0.07, and 0.08-0.06%, p = 0.14, respectively). SDI was not significantly correlated with percent change of EPLB (CC = 0.29, 95% CI = -0.12, 0.71) or EPIS (CC = -0.23, 95% CI = -0.65, 0.18). Percent change in mean gestational age was positively correlated with SDI (CC = 0.49, 95% CI = …

The Price Of Consent, Zohra Ahmed

Faculty Scholarship

This Article demonstrates how hierarchies in the international economy and in international financial institutions have facilitated the U.S.-led Global War on Terror (GWOT). Using U.S.-Pakistan relations as a case study, it shows how the United States has deployed its powerful position at the International Monetary Fund (IMF) to claim Pakistan's consent for its military activities in the region. In the GWOT's first decade, beginning in 2001, the United States openly sought forcible regime change, as in Afghanistan and Iraq; in its second and (now) third decades, the United States has waged covert counterinsurgency campaigns allegedly against militant groups in Muslim-majority …

Estimating The Potential Value Of Msm-Focused Evidence-Based Implementation Interventions In Three Ending The Hiv Epidemic Jurisdictions In The United States: A Model-Based Analysis, Benjamin Enns, Elvin H Geng, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Improving the delivery of existing evidence-based interventions to prevent and diagnose HIV is key to Ending the HIV Epidemic in the United States. Structural barriers in the access and delivery of related health services require municipal or state-level policy changes; however, suboptimal implementation can be addressed directly through interventions designed to improve the reach, effectiveness, adoption or maintenance of available interventions. Our objective was to estimate the cost-effectiveness and potential epidemiological impact of six real-world implementation interventions designed to address these barriers and increase the scale of delivery of interventions for HIV testing and pre-exposure prophylaxis (PrEP) in three …

Diverse Mentoring Connections Across Institutional Boundaries In The Biomedical Sciences: Innovative Graph Database Analysis, Toufeeq Ahmed Syed, Erika L Thompson, Zainab Latif, Jay Johnson, Damaris Javier, Katie Stinson, Gabrielle Saleh, Jamboor K Vishwanatha

Faculty, Staff and Student Publications

BACKGROUND: With an overarching goal of increasing diversity and inclusion in biomedical sciences, the National Research Mentoring Network (NRMN) developed a web-based national mentoring platform (MyNRMN) that seeks to connect mentors and mentees to support the persistence of underrepresented minorities in the biomedical sciences. As of May 15, 2024, the MyNRMN platform, which provides mentoring, networking, and professional development tools, has facilitated more than 12,100 unique mentoring connections between faculty, students, and researchers in the biomedical domain.

OBJECTIVE: This study aimed to examine the large-scale mentoring connections facilitated by our web-based platform between students (mentees) and faculty (mentors) across institutional …

The Psychological Risks Of War Between The United States And China, Eugen Koh

New England Journal of Public Policy

The relationship between the United States and China has deteriorated over the past two decades and fears of escalating risks of war are regularly reported in global media. This article explores the psychological factors that contribute to the two superpowers shifting from a collaborative relationship to a competitive relationship, seeing each other as enemies, feeling increasingly threatened by each other, failing to consider the heightened sensitivities that arise from their respective traumatic pasts, triggering the collapse of thinking and unleashing of uncontainable emotionality, escalating accidents to conflict, and escalating conflict to war. It highlights the dangers of ignoring heightened trauma-related …

Thriving In Theory, Missing The Mark: U.S. Organic Farming IndustryʼS Systemic Malfunctions And How Danish Organic Farming Policy Could Help Solve These Issues, Bailey Webster

San Diego Journal of Climate & Energy Law

Section one of this Article explains the overall framework of the U.S. organic farming industry, including certification, labeling, education, and funding. Section two explains the background and structure of Danish organic farming, administered by the Ministry of Food, Agriculture, and Fisheries of Denmark. Section three addresses and analyzes current issues afflicting the U.S. organic farming industry. Section four explores a prominent organic farming case, Center for Food Safety v. Perdue. Additionally, this Article details the comparison between the U.S. and Danish organic farming policies that are most relevant to issues in the U.S. industry. Lastly, and most importantly, this …

Things I'Ve Learned From Doing Cosplay: An Investigation On Incorporating “Atypical” Creative Practices Into Art Education, Yvonne Liang

Masters Theses

This thesis explores the pedagogical value of cosplay through a focused case study and autoethnography, highlighting its influence on identity formation and community engagement among youth. The autoethnographic component provides a personal perspective, enriching the empirical data collected from participants in a cosplay workshop. The case study delves into how cosplay encourages skill development, creativity, and emotional resilience, facilitating a supportive and dynamic learning environment for young adults. Insights from this research demonstrate the significant benefits of integrating cosplay into art education, suggesting it can greatly enhance student engagement and promote diverse educational experiences. This study contributes to the understanding …

Influence Of Parental Nativity And Perceived Neighborhood Environment On Physical Activity And Screen Time Of United States Youth, Natalia I Heredia, Ethan T Hunt, Kevin Lanza

Faculty, Staff and Student Publications

OBJECTIVE: This study assessed how parental nativity and perceived environment are associated with physical activity and screen time of U.S. children and adolescents.

METHODS: Data originated from the 2020-21 U.S. National Survey of Children's Health. We conducted multivariable Poisson regression to assess the cross-sectional association of parental nativity and perceived neighborhood environment variables on parental reports of youth meeting national physical activity and screen time guidelines. We tested interactions of parental nativity and neighborhood environment variables on both outcomes. Analyses were conducted using STATA v17 and p < 0.05 indicated statistical significance.

RESULTS: The sample of 24,928 children and 30,951 adolescents was 11.6 years of …

Authenticating Social Media Evidence In Chinese Criminal Procedure Law -- A Comparative Study, Yage Huang

Maurer Theses and Dissertations

Authentication requires the proponent to provide sufficient proof that the proposed social media evidence is, indeed, what it is claimed to be. The rapid proliferation of social media evidence has posed significant challenges for its authentication. This dissertation explores the authentication challenges for social media evidence in a comprehensive manner.

This research employs a qualitative research methodology, including theoretical and analytical methods, to examine the theoretical approaches, statutory provisions, and recent judicial rulings related to the authentication of social media evidence within the legal frameworks of China and the United States. Through a comparative analysis, this study reveals significant commonalities …

Evaluation Of Trauma Informed Care For Indigenous Victims Of Human Trafficking: A Qualitative Discussion Of Best Practice, Nina Munson

University Honors Theses

Human trafficking is a major issue that every community and nation faces. Within the United States, Indigenous communities are especially at risk of victimization in relation to a history of systemic violence and consequent neglect. Therefore, the need for culturally competent care is crucial. This study seeks to address how culturally sensitive approaches to trauma-informed care can be developed and implemented by various providers to effectively support Native American victims of human trafficking in accessing assistance services. In order to evaluate the problem, a literature review was conducted, paired with qualitative interviews from relevant stakeholders. The findings demonstrated a significant …

Profiles In Influence: Shaping American Perceptions, Attitudes, And Policy Towards China, Benjamin Merritt

Masters Theses

Pearl Buck, Henry Luce, Edgar Snow, and Richard Nixon have profoundly influenced Sino-American relations throughout the 20th century. Their impact on American perceptions, attitudes, and foreign policy has played a pivotal role in shaping the current state of relations between the United States government and the People’s Republic of China. Pivotal historical events such as WWI & WWII, the Sino-Japanese War, China’s Civil War, and the Soviet-Sino conflict—among other events—have also significantly influenced the dynamics of Sino-American relations. Despite their importance, there is a notable absence of studies that comprehensively explore the collective impact of these individuals and events. Understanding …

Central Bank Liquidity Assistance: Challenges Of Franchise And Asset Values In Banking Crises, Steven Kelly

Documents

No abstract provided.

Politicization And Economic Benefits Of Renewable Energy, Sean T. Cunningham

Honors Theses

With climate change posing an imminent threat to our planet, it has become an ever more prominent question as to how we can curve the effects of it. One of the most popular proposed solutions to curb emissions is renewable energy. With solar, wind, and other types of renewable energy sources, we could rely on energy sources that produce zero emissions. However, it has become a hotly debated issue in the media, especially in the United States. What my research does is examine and unpack themes in the rhetoric of conservative-leaning media outlets that speak against renewable energy, examine the …

Exome Sequencing Implicates Ancestry-Related Mendelian Variation At Syne1 In Childhood-Onset Essential Hypertension, Ian Copeland, Edmond Wonkam-Tingang, Monesha Gupta-Malhotra, S Shahrukh Hashmi, Yixing Han, Aarti Jajoo, Nancy J Hall, Paula P Hernandez, Natasha Lie, Dan Liu, Jun Xu, Jill Rosenfeld, Aparna Haldipur, Zelene Desire, Zeynep H Coban-Akdemir, Daryl A Scott, Qing Li, Hsiao-Tuan Chao, Ana M Zaske, James R Lupski, Dianna M Milewicz, Sanjay Shete, Jennifer E Posey, Neil A Hanchard

Faculty, Staff and Student Publications

Childhood-onset essential hypertension (COEH) is an uncommon form of hypertension that manifests in childhood or adolescence and, in the United States, disproportionately affects children of African ancestry. The etiology of COEH is unknown, but its childhood onset, low prevalence, high heritability, and skewed ancestral demography suggest the potential to identify rare genetic variation segregating in a Mendelian manner among affected individuals and thereby implicate genes important to disease pathogenesis. However, no COEH genes have been reported to date. Here, we identify recessive segregation of rare and putatively damaging missense variation in the spectrin domain of spectrin repeat containing nuclear envelope …

Examining The Implications Of A Significant Cyberattack On U.S. Infrastructure, Jenna F. Riel

Honors Theses

In the modern era, the internet is becoming just as essential to the functioning of our everyday lives as food and water. Virtually everything we do relies on modern technology in some capacity, allowing our world to function efficiently. The technology that we have available has made our world smaller in a sense, because digital interconnectedness has allowed us to communicate with anyone no matter where they are on the globe in a matter of seconds, with the tap of a finger. This idea, once a phenomenon only possible in storybooks, has come to life but is not without its …

Boundaries Of Autonomy: Exploring Parallels Between Mental Hospitals And Prisons In The United States, Benjamin J. Boldt

The Agora

Within the United States, a prevailing perception emerges that mental health facilities and prisons are unfavorably similar. This societal sentiment is quite concerning if true, as the prison system is known for its many societal failures within the U.S. Furthermore, mental hospitals aim to help individuals; thus, a comparison to a faulty system highlights a possible issue worthy of exploration. Unfortunately, little analysis exists, within academic research, comparing both institutions. The following comparative analysis looks at available research between mental hospitals and prisons to validate this issue and explore implications. Findings indicate a shared pattern between mental hospitals and prisons …

Mexican Money Laundering In The United States: Analysis And Proposals For Reform, Guadalupe Correa-Cabrera, Charles Lewis, William R. Yaworsky

Anthropology Faculty Publications

This article explains some of the mechanisms through which corruption by high-level Mexican politicians and other organized crime members is facilitated in the United States through money laundering operations. The analysis is based on information contained in court records related to key money laundering cases, as well as in news articles and reports from law enforcement agencies. These materials highlight the interrelationships among U.S. drug use, cartel activities in Mexico, human rights abuses, Mexican political corruption, and money laundering in the United States. This work demonstrates the pervasive use of legitimate businesses and fronts in the United States as a …

Assessing The Relationship Between Racism In Medicine, Medical Mistrust And Cardiovascular Disease Among Black American Adults., Osayande Agbonlahor

Electronic Theses and Dissertations

Cardiovascular disease (CVD) persists as the leading preventable cause of death and disability among Black Americans in the United States. Structural and psychosocial factors such as racism have been highlighted as a fundamental cause of persistent cardiovascular health disparities in the U.S. This study examined the associations between racism in medicine, medical mistrust and CVD among Black Americans using the Minority Stress Theory as a theoretical framework. This study evaluates the sociodemographic differences in the quality of care received among Black Americans. Data from the Health Information National Trends Survey, 2022 and the Consumer Assessment of Healthcare Provider and Systems …

Give It A Nudge: A Comparative Analysis Of The Values And Application Of Voluntary Environmental Programs In The United States, Pianpian Wang

Dissertations & Theses

In recent years, companies have increased their voluntary commitments to reducing carbon emissions and implementing sustainability goals. While existing research mainly focuses on government-organized voluntary environmental programs (VEPs), exploring corporate voluntary commitments is essential. The business sector’s active role in environmental management is noteworthy. Traditionally, governments have relied on command-and-control regulations and market incentives to compel companies to protect the environment. However, companies are now demonstrating a willingness to go beyond legal requirements. Naturally, we seek answers to whether these commitments are effective, what factors can contribute to their authenticity, and how we compare these voluntary commitments to other VEPs. …

That Way: An Examination Of Male Relationships In Film During The Hays Code, Jane Knudsen

Theses/Capstones/Creative Projects

The Hays Code (1934-1968) influenced the construct of United States masculinity and the discourse surrounding masculine presentation between the 1920s to the 1960s. The Hays Code and World War II affected the culture surrounding male/male relationships in the United States. Previous research done by David Lugowski (1999) and Jeffrey Suzik (1999) shows that both World Wars led to crises of masculinity in which the hegemonic ideal of masculinity was restructured to establish men as providers and warriors, and Code-era films reflected the discourse. To understand the gender roles in the 20^th century, I analyzed the Hays code, male bonds, …

A Literature Review Of Societal Obesity And Its Impact On United States Military Recruitment, Megan Thibodeaux

Capstone Experience: Master of Public Health

In recent decades, obesity rates have increased in the United States, raising significant health and societal concerns, especially in terms of military readiness. The ever-rising rates of weight-related health obstacles present a critical national security issue as it impacts the effectiveness of recruitment. This literature review aims to analyze how obesity impacts military recruitment and readiness to serve while utilizing the socio-ecological model to help determine gaps in evidence. Data was drawn from Embase, PubMed, and PsychInfo. Inclusion criteria consisted of academic journals and reports from government and non-profit organizations written in English. They focused only on the United States …

Fast Fashion: A Thorough Examination On Human Rights Violations In Bangladesh And Global Environmental Degradation, Maggie Quiroz

International Studies (MA) Theses

Fast fashion is one of the most popular industries in the world as it provides consumers with clothing at an affordable price, however, despite its heightened popularity, it is one of the leading industries in human rights violations and environmental degradation. The thesis explores the different implications of fast fashion in a form that focuses on the human right violations workers are enduring and the global effect of such high demand for fast fashion. It uses a mixed methodology composed of both qualitative and quantitative data. Qualitative data is used to analyze the historical impact fast fashion has on human …