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Insane In The Brain, Blood, And Lungs: Gender-Specific Manifestations Of Hysteria, Chlorosis, & Consumption In 19th-Century Literature, Anna P. Scanlon

Dissertations (1934 -)

This dissertation examines literary and medical texts from throughout the nineteenth and early twentieth centuries to better understand prevailing attitudes about gender and disease. The project traces the progression of three diseases – consumption, chlorosis, and hysteria – throughout the long nineteenth century, paying particular attention to the stereotypes and prevailing medical notions of each illness. In general, this work examines the influence of lovesickness, female-patient/male-doctor dynamics, and pathology on the endemic or epidemic nature of each disease. In particular, the first three chapters of this project study tuberculosis – or consumption as it was called in the nineteenth century …

The Current State Of Animal Models And Genomic Approaches Towards Identifying And Validating Molecular Determinants Of Mycobacterium Tuberculosis Infection And Tuberculosis Disease, Allison N Bucsan, Smriti Mehra, Shabaana A Khader, Deepak Kaushal

2010-2019 OA Pubs

Animal models are important in understanding both the pathogenesis of and immunity to tuberculosis (TB). Unfortunately, we are beginning to understand that no animal model perfectly recapitulates the human TB syndrome, which encompasses numerous different stages. Furthermore, Mycobacterium tuberculosis infection is a very heterogeneous event at both the levels of pathogenesis and immunity. This review seeks to establish the current understanding of TB pathogenesis and immunity, as validated in the animal models of TB in active use today. We especially focus on the use of modern genomic approaches in these models to determine the mechanism and the role of specific …

A Pilot Project For School-Based Screening And Treatment Of Latent Tb Infection Among Freshman High School Students, Isis Cunningham

Doctor of Nursing Practice Final Manuscripts

Background: San Diego’s tuberculosis (TB) incidence is 2.5 times higher than the national rate. Five cases of active TB in the county’s public high schools during 2018 demonstrated the need for prevention interventions in this setting.

Objectives: This evidence-based project aimed to increase awareness, screening, and treatment of latent TB infection (LTBI) in the school setting.

Methods: A one-time TB educational presentation was given to high school freshman students with a pretest and posttest. A TB risk assessment and consent was sent home with the students. For at-risk students, a confidential package was sent to the parents recommending testing along …

Spatial Distribution Of Tuberculosis And Its Association With Meteorological Factors In Mainland China, Yingjie Zhang, Mengyang Liu, Samuel S. Wu, Hui Jiang, Junjie Zhang, Songwang Wang, Wei Ma, Qihuan Li, Yuan Ma, Yue Liu, Wei Feng, Endawoke Amsalu, Xia Li, Wei Wang, Weimin Li, Xiuhua Guo

Research outputs 2014 to 2021

BACKGROUND: The incidence of tuberculosis (TB) remains high worldwide. Current strategies will not eradicate TB by 2035; instead, by 2182 is more likely. Therefore, it is urgent that new risk factors be identified.

METHODS: An ecological study was conducted in 340 prefectures in China from 2005 to 2015. The spatial distribution of TB incidence was shown by clustering and hotspot analysis. The relationship between the distribution patterns and six meteorological factors was evaluated by the geographically weighted regression (GWR) model.

RESULTS: During the 11 years of the study period, TB incidence was persistently low in the east and high in …

Data Visualization Of Treatment Outcomes For Tuberculosis Patients, Joy Jenkins

Industrial Engineering Undergraduate Honors Theses

Tuberculosis is an infectious disease, and different treatments have been discovered over the years. However, patients may develop various drug resistance levels that affect the likelihood of becoming cured or dying. In this study, we sought to employ data visualization to explore the relationship between treatment trajectory, as indicated by smear and culture results in the follow-up tests and patient outcomes. A large sample of patients have been broken down by demographics including age, gender, and drug resistance status. Sankey diagrams were used to visualize the pathway progression of the patients over time split between two time periods- months 0-6 …

Tuberculosis Of Male Breast: A Rare Benign Entity, Kulsoom Fatima, Farah Naz

Department of Radiology

Granulomatous mastitis is a rare benign condition often seen in young lactating females of reproductive age group. Prepubescent males or elderly women may also be the victim of this infectious disease. Primary infection of the breast may occur through skin abrasions, open wounds or through the lactiferous ducts while secondary spread occurs from an infective focus elsewhere in the body via lymphatic or hematogenous routes. We present a case of breast tuberculosis diagnosed in a 62-year-old man at our institution. The patient presented with a palpable painful mass in the left breast with chronic sinus formation and pus discharge for …

The Re-Emerging Association Between Tuberculosis And Diabetes: Lessons From Past Centuries, Jose Cadena, Selvalakshmi Rathinavelu, Juan Carlos Lopez Alvarenga, Blanca I. Restrepo

School of Medicine Publications

The association between tuberculosis (TB) and diabetes mellitus (DM) had a common place in the literature up to the first half of the 20th century, but virtually disappeared with the discovery of insulin to treat DM and antibiotics to cure TB. In the late 1990s the literature began to re-emerge with the worldwide increase in type 2 DM, particularly in TB-endemic countries. Today, type 2 DM is the most prevalent comorbidity among TB patients and the World Health Organization considers it a threat to TB control. We summarize the literature on TB and DM up to the 1960s. Then we …

Dose Dispensing Tool For Pediatric Drug-Resistant Tuberculosis, Miza Mwanza, Ebony N. Smith, Jamie H. Au, Wei Wei Buchsteiner

ENGS 89/90 Reports

There are no current second-line antibiotics for children with Multidrug Resistant Tuberculosis (MDR TB). Current methods to treat pediatric MDR TB consist of splitting up adult formulated pills in accordance to the WHO’s recommended dosages, which depend on the weight and age of the child. This process is very inconsistent, tedious, and time consuming when using the state-of-the-art tools (kitchen knives, standard pill cutters). Under the sponsorship of Health Advocacy Innovations (HAI), we developed a mechanical tool that makes ingesting pills for child patients more convenient, consistent, and swift. Our dose-dispensing tool cuts pills into quarters, stores 30 pills, dispenses …

Eis Inhibitors, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, James E. Posey

Pharmaceutical Sciences Faculty Patents

Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.

Apopo Annual Report 2019, Apopo

Global CWD Repository

APOPO originated from the idea of its founder Bart Weetjens to trains rats for the detection of landmines. Now, over 20 years later, APOPO deploys rats to find landmines and tuberculosis in many affected countries, and continues innovating to use its African Giant Pouched Rats in the battle against other scourges.

APOPO trains these ‘HeroRATs’ using positive reinforcement – they receive tasty treats when they identify a target scent. HeroRATs are at the core of the organization and it’s reflected in the way they are protected and responsibly raised.

Our Training and Research center is based at the foothills of …

Development Of Luminescent Tools For Use In The Study Of Mycobacterium Tuberculosis, Krista A. Moore

Honors Undergraduate Theses

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a growing problem worldwide due to the emergence of multi-drug resistant and extensively-drug resistant strains of the bacteria. A key to combatting the spread of these strains lies in the understanding of gene expression occurring in Mtb. This study focuses on the development and optimization of a luciferase-based bioluminescent transcriptional reporter that can be used to monitor gene expression in Mtb. The luminescent signal emitted from the reporter can be measured and correlated with the level of transcription of certain genes. This study focuses specifically on a gene called whiB7 which …

Pulmonary Vein Thrombosis Secondary To Tuberculosis In A Non-Hiv Infected Patient, Yonas Raru, Jason Ballengee, Mahmoud Abouzid, Samson Teka

Pulmonology

Tuberculosis has been suggested as an independent risk factor for thromboembolism due to a hypercoagulable state induced by changes in clotting factors, protein C and vascular endothelium. Pulmonary vein thrombosis (PVT) is a rare, potentially serious and life-threatening condition that can be caused by tuberculosis. Its rare occurrence is due to a rich network of venous collateral vessels that drain the lung. PVT can also occur following lobectomy for malignancy, lung transplantation, radiofrequency catheter ablation for atrial fibrillation, sclerosing mediastinitis and following metastatic cancer, such as liposarcoma. Pulmonary vein thrombosis is difficult to diagnose clinically and requires a combination of …

Assessing The Tuberculosis (Tb) Screening Compliance Rates And Treatment Completion Among International Students At The University Of Kentucky, Bongiwe P. Malinga

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Tuberculosis early screening and diagnosis are cost-effective strategies for infection control. Tuberculosis elimination which is aimed for 2030 requires that both latent tuberculosis and active disease be fully treated. This study measures the tuberculosis screening rates and treatment completion rates among the international students at the University of Kentucky between 2016 and 2018.

Methods: This retrospective cohort study included all J1 and F1 student visa holders enrolling from 2016 fall to 2017 fall. To accommodate the nine months treatment completion, the cohort period overlapped to 2018. Data were provided by the University Health Services and the sample size …

Predictors Of Incomplete Evaluation Among Pediatric Household Contacts Of Pulmonary Tuberculosis Patients In Kampala, Uganda: A Secondary Analysis, Giyoung Lee

Public Health Theses

Background: Contact investigation is an active approach to identifying new TB cases by screening contacts of known patients for symptoms and risk factors. This is particularly important for child contacts of TB patients because young children are at higher risk of progressing to severe disease compared to adults. Moreover, children are unable or unlikely to travel to clinics for evaluation independently, so their access to TB evaluation may depend on the adults in their household.

Objective: To evaluate the association between individual- and household-level characteristics and completion of TB evaluation for children under 15 years.

Setting: Seven public tuberculosis (TB) …

Assessment Of Tuberculosis Underreporting By Level Of Reporting System In Lagos, Nigeria, Mustapha Gidado

Walden Dissertations and Doctoral Studies

Abstract

Tuberculosis (TB) is the leading cause of death from a single infectious disease. Unfortunately, 4.1 million cases were missed in 2017 globally, and Nigeria contributes 9% of the missing TB cases. At least 73% of the estimated TB cases in Nigeria were not reported in 2017 to the National TB Program (NTP); therefore, the true burden of TB was not certain, and this affected planning for prevention and control of TB. This quantitative secondary data analysis (NTP Lagos TB Inventory study database) guided by the integrated behavioral model assessed TB underreporting based on the TB reporting process in Nigeria. …

Impact Of Technology On Improving Hiv And Tuberculosis Health Outcomes Among African Countries, Sunny Ibeneme

Dissertations and Theses (Open Access)

This study used health analytics approach to evaluate the association between population health outcomes and Information and Communication Technology (ICT) infrastructures at a country level. This study used aggregate data obtained from the World Bank database, and the International Telecommunication Union (ITU) database for 53 African countries for the periods 2000 to 2016, and quantitatively explored the impact of ICT infrastructures’ diffusion on population health outcomes.

ICT data was obtained from the ITU database. Similarly, population health attributes were retrieved from the World Bank database. ICT infrastructure variables used in this study include: internet access, mobile phone use, and fixed …

Parameter Estimation And Optimal Control Of The Dynamics Of Transmission Of Tuberculosis With Application To Cameroon, A. Temgoua, Y. Malong, J. Mbang, S. Bowong

Applications and Applied Mathematics: An International Journal (AAM)

This paper deals with the problem of parameter estimation and optimal control of a tuberculosis (TB) model with seasonal fluctuations. We first present a uncontrolled TB model with seasonal fluctuations. We present the theoretical analysis of the uncontrolled TB model without seasonal fluctuations. After, we propose a numerical study to estimate the unknown parameters of the TB model with seasonal fluctuations according to demographic and epidemiological data from Cameroon. Simulation results are in good accordance with the seasonal variation of the new active reported cases of TB in Cameroon. Using this TB model with seasonality, the tuberculosis control is formulated …

Spatial And Temporal Clustering Analysis Of Tuberculosis In The Mainland Of China At The Prefecture Level, 2005-2015, Meng-Yang Liu, Qi-Huan Li, Ying-Jie Zhang, Yuan Ma, Yue Liu, Wei Feng, Cheng-Bei Hou, Endawoke Amsalu, Xia Li, Wei Wang, Wei-Min Li, Xiu-Hua Guo

Research outputs 2014 to 2021

BACKGROUND: Tuberculosis (TB) is still one of the most serious infectious diseases in the mainland of China. So it was urgent for the formulation of more effective measures to prevent and control it.

METHODS: The data of reported TB cases in 340 prefectures from the mainland of China were extracted from the China Information System for Disease Control and Prevention (CISDCP) during January 2005 to December 2015. The Kulldorff's retrospective space-time scan statistics was used to identify the temporal, spatial and spatio-temporal clusters of reported TB in the mainland of China by using the discrete Poisson probability model. Spatio-temporal clusters …

Construction Of Pcdna3.1 Vector Encoding Rpfd Gene Of Mycobacterium Tuberculosis, Aprilia Rakhmawati, Andriansjah Rukmana, Anis Karuniawati

Makara Journal of Science

Tuberculosis (TB) is an infectious diseasecaused by Mycobacterium tuberculosis (M. tuberculosis). TB is still a major health problem. The Bacillus Calmette-Guérin (BCG) vaccineis the only one available for TB and is known to confer variable levels of protection. Because of thisvariability, a new vaccine is needed to control TB. Proteins secreted by M.tuberculosisare known to induce protective immunity. Within the genome of M. tuberculosis, there is a family of proteins called resuscitation promoting factor (Rpf), which playsa role in the reactivation of M. tuberculosis. RpfD is amember of the Rpf family that has been shown to be immunogenic, makingitsuitable for …

To Identify The Features Differentiating Peritoneal Tuberculosis From Carcinomatosis On Ct Scan Abdomen Taking Omental Biopsy As A Gold Standard, Farah Naz Farid, Waseem Akhtar, Nauman Hashmani, Raza Sayani

Department of Surgery Docs

OBJECTIVE:
To differentiate peritoneal tuberculosis from carcinomatosis on computed tomography scan of abdomen, taking omental biopsy as the gold standard.. METHODS:
This retrospective diagnostic accuracy review of cases was conducted at Aga Khan University Hospital, Karachi, and comprised patient's medical record files from February 2007 to February 2016. Computed tomography scan findings were compared with diagnosis made on the basis of histopathology. Multiple logistics regression analysis was done and sensitivity and specificity were tested through Pearson chi square test.
RESULTS:
Of the 98 patients identified, 62(63.2%)were found to be cases of disseminated tuberculosis and 36(36.7%) were diagnosed as malignant on …

Propargyl-Linked Antifolates As Inhibitors Of The Folate Biosynthetic Pathway In Mycobacterium Tuberculosis And M. Avium, Behnoush Hajian

Doctoral Dissertations

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has co-evolved with humans since the dawn of our species. Despite advances in antibiotic therapy, TB global burden is till enormous. Antimicrobial resistance and HIV epidemic challenge the ongoing efforts to control TB. Novel anti-TB agents are required to address the issues associated with current drug regimens and to improve the outcomes of TB therapy. In this work, we have evaluated the antimycobacterial activity of propargyl-linked antifolates against drug-susceptible and drug-resistant M. tuberculosis. Antifolates exerts their antimicrobial effect by interruption of folate biosynthetic pathway and one-carbon metabolism. We have successfully …

Identification Of Bhlhe40 And Irg1 As Essential Regulators Of The Inflammatory Response To Mycobacterium Tuberculosis, Jeremy Peter Huynh

Arts & Sciences Graduate Student Theses and Dissertations

Protective immune responses to Mycobacterium tuberculosis (Mtb) must induce bactericidal functions while minimizing damage to the lung. Such responses require precise control of pro- and anti-inflammatory factors to regulate the recruitment and function of protective immune cells but the mechanisms by which this control is exerted remain incompletely defined. Basic helix-loop-helix family, member e40 (Bhlhe40) is a transcription factor known to regulate production of pro- and anti-inflammatory cytokines that affect protective immunity to Mtb. Immune-responsive Gene 1 (Irg1) is an enzyme that generates itaconate, a metabolite with potential anti-inflammatory and antibacterial roles during Mtb infection. The impact of Bhlhe40 and …

Cardiovascular Risk Among Patients With Drug-Resistant Tuberculosis And Hiv In South Africa, Erin Rachel Whitehouse

Dissertations

South Africa has the highest incidence of drug resistant-tuberculosis (DR-TB) in sub-Saharan Africa and outcomes are poor. Only 54% of patients successfully complete treatment. The prevalence of HIV co-infection and cardiovascular (CVD) risk factors is also increasing. The purpose of this study was to describe cardiovascular risk in DR-TB patients with and without HIV co-infection and the impact of this risk on 6-month DR-TB negative treatment outcomes among patients co-infected with HIV.

Assessment Of Risk Factors Of Hepatotoxicity Among Tuberculosis Patients, Muhammad F. Wardhana, Tiana Milanda, Sri A. Sumiwi

Pharmacology and Clinical Pharmacy Research

Tuberculosis is a devastating disease caused by Mycobacterium tuberculosis. If left untreated or not properly treated, it could lead to progressive tissue damage and even death. Short-term chemotherapy containing isoniazid, rifampicin. and pyrazinamide were proven to be very effective in the treatment of TB. However, the concern regarding its potential hepatotoxicity might hinder the completion of treatment. Information regarding risk factor of hepatotoxicity among Indonesian tuberculosis patients were limited. This study aimed to investigate risk factors of hepatotoxicity among Indonesian tuberculosis patients. This was a case-control study with retrospective approach conducted at one of the public hospital in Lampung, Indonesia. …

In Vivo Inhibition Of Tryptophan Catabolism Reorganizes The Tuberculoma And Augments Immune-Mediated Control Of Mycobacterium Tuberculosis, Uma S. Gautam, Taylor W. Foreman, Allison N. Bucsan, Ashley V. Veatch, Xavier Alvarez, Toidi Adekambi, Nadia A. Golden, Kaylee M. Gentry, Lara A. Doyle-Meyers, Kasi E. Russell-Lodrigue, Peter J. Didier, James L. Blanchard, K. Gus Kousoulas, Andrew A. Lackner, Daniel Kalman, Jyothi Rengarajan, Shabaana A. Khader, Deepak Kaushal, Smriti Mehra

Faculty Publications

Mycobacterium tuberculosis continues to cause devastating levels of mortality due to tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the highly specialized strategies that M. tuberculosis utilizes to modulate host immunity and thereby persist in host lungs. Here, we show that M. tuberculosis induced the expression of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in tryptophan catabolism, in macrophages and in the lungs of animals (mice and macaque) with active disease. In a macaque model of inhalation TB, suppression of IDO activity reduced bacterial burden, pathology, and clinical signs of TB disease, leading to increased host …

The Gambia : Tuberculosis, Amen Belayneh

Global Public Health

Tuberculosis in the Gambia

This brief consists of some general information about Gambia, demographic information, the effects of tuberculosis in the country including the challenges brought forth by the disease, and some personal suggestions on the matter. From the general information on Gambia, we learn the location, political structure as well as major internal and external challenges faced by the country. Tuberculosis is one of the country’s major internal challenges in addition to its environmental and economic issues. Under the demographic information we get a broader idea of the Gambia people by looking at population demographic such as birth and …

Micronesia: Tuberculosis, Mulualem Hailom

Global Public Health

This brief contains the general information of the Federal state of Micronesia, major problems of the country, and in particular Tuberculosis disease and Multidrug-Resistant Tuberculosis. Under the general information of Micronesia, the location, the political structure, the demographic information, and the internal and also external challenges are listed. This brief also has detailed information about the two simultaneous outbreaks of Multidrug-Resistant Tuberculosis of Micronesia. Tuberculosis is one of death contributing factor in Micronesia. Tuberculosis can be cured if the therapy is properly taken but if the therapy isn’t taken properly, the TB disease can grow into Multidrug –Resistance tuberculosis, which …

Mycobacterium Tuberculosis Infection In The Setting Of Interstitial Lung Disease: Coincidence Or Bad Luck?, Christian Wong, Sonu Sahni, Muhammad Azaz I. Cheema, Asma Iftikhar

Touro College of Osteopathic Medicine (New York) Publications and Research

Mycobacterium tuberculosis (MTB) infection is the ninth leading cause of death worldwide, with many individuals with undiagnosed active or latent disease. The presence of parenchymal lung disease, such as interstitial lung disease (ILD), has been suggested to increase the risk of pulmonary tuberculosis (TB). In the clinical setting of ILD, the diagnosis of an underlying MTB infection may be challenging due to the interstitial process and underlying fibrosis, which may mask the infection. An atypical presentation and misleading radiological patterns may delay the diagnosis of the underlying MTB infection. Herein, we describe a unique case of ILD complicated by active …

Pooled Analysis Of 163 Published Tuberculous Peritonitis Cases From Turkey, Bedi̇a Mutay Suntur, Feri̇t Kuşcu

Turkish Journal of Medical Sciences

Background/aim: Tuberculous peritonitis may be di cult to diagnose due to its insidious and variable clinical manifestations as well as characteristics similar to malignancy. In this study, case reports from Turkey over the last 10 years were reviewed systematically using pooled analysis. Materials and methods: irty-four suitable articles were found and 163 tuberculous peritonitis cases were included in the study. Results: e mean age was 34.1 years (17?79 years), and 146 (98.6%) of the patients were female and 17 (10.4%) were male. e most common complaints of these patients were abdominal pain (77.4%) and abdominal distention (73.5%). Ascites in the …

Human Immunodeficiency Virus And Tuberculosis Coinfection: Clinical Features And Predictors Of Mortality, Fatma Gümüşer, Merve Altinkaynak, Di̇lek Yildiz Sevgi̇, Özlem Altuntaş Aydin, Bi̇lgül Mete, Alper Gündüz, Hayat Kumbasar Karaosmanoğlu, Si̇bel Bolukçu, Ömer Fehmi̇ Tabak, Mustafa Haluk Vahaboğlu

Turkish Journal of Medical Sciences

Background/aim: This study was undertaken to identify subjects with human immunodeficiency virus and tuberculosis (HIV/TB) coinfection in a group of HIV-positive patients followed at five different healthcare centers, and to determine the demographic and clinical characteristics of these subjects as well as the predictors of mortality. Materials and methods: A database search for subjects with TB coinfection was performed among 1475 HIV-positive adult patients and a total of 66 individuals were identified with HIV/TB coinfection. Results: There were 66 patients (4.5%) with TB coinfection. Twenty-one percent (n = 14) of the patients with TB coinfection died during the study period …