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Global Pharmaceutical Patent Law In Developing Countries- Amending Trips To Promote Access For All, Angela J. Anderson

ExpressO

This comment will analyze the need to amend and revise the current global pharmaceutical patent system under TRIPS to take into account the needs of developing countries and overall public health. This comment will emphasize that the current international trade rules, which although administered by the WTO, are dictated by developed country governments and powerful pharmaceutical companies, and therefore, without reform will further diminish the access of poor people in developing countries to vital medicines. Part II of this comment will provide a general overview of the international trade law governing patents on pharmaceuticals focusing specifically on the development of …

Laboratory Diagnosis Of Tuberculosis In Primary Care, David Brett-Major, Thomas E. Walsh

Journal Articles: Epidemiology

No abstract provided.

Synthesis Of 2-Oxo-16-(3', 4'-Methylenedioxyphenyl)-Trans-15-Hexadecene, Adelajda Zorba

Honors Theses

This work presents the progress made towards synthesizing 2-oxo-16-(3', 4'methylenedioxyphenyl)-trans-15-hexadecene, an antimycobacterial compound that was originally isolated from the leaves of Piper Sanctum. The hydrocarbon chain of the molecule was synthesized first by opening a 15-pentadecanolactone ring by means of HI, and performing an E2 elimination reaction on the molecule followed by an organolithium reaction with CH3Li. Hexadec-15-en-2-one that was afforded this way was later reacted with 5-bromobenzo[d][1,3]dioxole following the appropriate Heck reaction protocol that allows for the formation of a palladium catalyzed carbon-carbon bond.

The modes of action of 2-oxo-16-(3', 4'-methylenedioxyphenyl)-trans-15hexadecene are comparable to the ones of rifampicin, a …

Tuberculosis In Hiv/Aids Patients: A Malaysian Experience, V. Nissapatorn, I. Kuppusamy, B.L.H. Sim, K.F. Quek, A. Khairul Anuar

Research Publications (2000 to 2005)

This retrospective study was conducted at the National Tuberculosis Center (NTBC) where 252 HIV-positive patients coexisting with tuberculosis (TB/HIV) were examined. We found that patients with pulmonary (PTB) and extrapulmonary tuberculosis (EPT) had similar mean age. A higher sex ratio between male to female (10.7:1) was observed in patients with PTB. The other characteristics of patients with pulmonary and extrapulmonary tuberculosis were not statistically different from each other. Cough (88) and hemoptysis were the most common presenting symptoms, significantly related to patients with PTB. Lymphadenopathy (33.5) was the most common sign in patients with EPT. The majority of patients with …

Patterns Of Tuberculosis In The Central Nervous System, Soobia Raza, Aliyah Sadaf, Faisal Fecto, Rushna Pervez Ali, Muhammad Ehsan Bari, Ather Enam

Medical College Documents

Tuberculous involvement of central nervous system (CNS), although not very frequent, results in severe morbidity. Tuberculosis (TB) is endemic in developing countries but even in developed countries, after an initial decline up until 1980’s, incidence of TB is on the rise. The AIDS epidemic, emergence of multi-drug resistant strains and immigration of people from endemic areas are some of the factors significantly contributing to this increase. Consequently, the burden of central nervous system tuberculosis has increased significantly worldwide.

Socio-Economic And Diagnostic Aspects Of Tuberculosis In Pakistan, Saba Sohail

Department of Radiology

No abstract provided.

Bilateral Cervical Radiculopathy As A Presentation Of Spinal Tuberculosis: Report Of Two Cases, G R. Sharma, Rashid Jooma

Section of Neurosurgery

No abstract provided.

Public Health Strategies To Control A Tuberculosis Outbreak In A Homeless Shelter, Jamilah Abdullah Ali

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

Tb Or Not Tb: Disease And The Adaptiveness Of Political Borders, Ibpp Editor

International Bulletin of Political Psychology

This article describes adaptive and nonadaptive aspects of political borders at the threshold of the 21st century.

Absence Of Tuberculosis In Free-Ranging Deer In Nebraska, David J. Steffen, David W. Oates, Mauritz C. Sterner, Vickie L. Cooper

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Lymph nodes from 271 white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) in Nebraska (USA) were examined microscopically for tuberculoid lesions. Lymph nodes lesions in at least one node were found in 12 deer. Lesions were examined with Zeihl-Neelson acid fast stains and by polymerase chain reactions using M. bovis specific probes. No evidence of tuberculosis was found. The small granulomatous lesions were likely caused by other bacteria.

Balancing The Barriers: Exploiting And Creating Incentives To Promote Development Of New Tuberculosis Treatments, Patricia C. Kuszler

Articles

This Article considers the many barriers that health-care providers and public health authorities face in stemming the modem TB epidemic. Part II reviews historical public health measures, their results, and their adaptability to resurgent and MDR-TB. Part III considers the fundamental barriers to a successful global effort using these public health strategies, concluding that these barriers are insurmountable given the current arsenal of anti-tuberculosis therapies. Part IV examines the reasons why research and development of new anti-tuberculosis drugs and vaccines have stagnated over the last quarter century. Finally, part V explores incentives that might revive research and development of such …

Search Magazine 1995, Winter, The Rockefeller University

Search Magazine

No abstract provided.

Tuberculosis And The Power Of The State: Toward The Development Of Rational Standards For The Review Of Compulsory Public Health Powers, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

This article uses tuberculosis as the paradigm for exploring rational standards for the exercise of compulsory public health powers. Extant doctrine in disability and constitutional law provides a lens for examining judicial review of state interventions. The author first sets out the central epidemiological and biological aspects of tuberculosis to demonstrate the strength of the governmental interest in curtailing the epidemic. Second, he examines the interventions of testing, screening, and confinement of persons with tuberculosis, where he focuses on two congregate settings--correctional and health care facilities--that present substantial health risks and are principal foci for the exercise of state intervention. …

The Resurgent Tuberculosis Epidemic In The Era Of Aids: Reflections On Public Health, Law, And Society, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

The resurgence of tuberculosis and the rise in drug-resistant cases is neither inexplicable nor unexpected, but rather is the predictable outcome of a complex configuration of biological, social, and behavioral factors that have converged in America over the past decade. This article examines the biological, social, and behavioral causes of the epidemic, and suggests a comprehensive public health strategy for curtailing tuberculosis and other infectious diseases. When thoughtfully conceived, public health strategies can be implemented that are consistent with the limitations that both constitutional law and disability law place on the authority of the state. While traditional concepts of public …

Jails And Prisons – Reservoirs Of Tb Disease: Should Defendants With Hiv Infection (Who Cannot Swim) Be Thrown Into The Reservoir?, Faith Colangelo, Mariana Hogan

Articles & Chapters

No abstract provided.

Dietary Protein Deficiency And Mycobacterium Bovis Bcg Affect Interleukin-2 Activity In Experimental Pulmonary Tuberculosis, David N. Mcmurray, C. L. Mintzer, R. A. Bartow, Rebecca D. Parr

Faculty Publications

Inbred strain 2 guinea pigs were vaccinated with Mycobacterium bovis BCG or were left unvaccinated. They were maintained for 6 weeks on defined, isocaloric diets containing either 30% (control animals) or 10% (animals receiving low protein) ovalbumin as the sole protein source. Animals were challenged by the respiratory route with a low dose of virulent M. tuberculosis H37Rv and killed 4 weeks later. Protein-malnourished animals were not protected by previous vaccination with BCG. Lymphocytes isolated from various tissues were tested in vitro for proliferative responses to mitogen (concanavalin A) and antigen (purified protein derivative [PPD]), production of interleukin-2 (IL-2), and …

Bovine Tuberculosis Control In Western Australia : Past, Present And Future, M R. Gardiner

Journal of the Department of Agriculture, Western Australia, Series 4

TWENTY YEARS AGO, tuberculosis was a widespread and serious disease in the dairy cattle of Western Australia.

Besides having a marked depressing effect on the economy of the dairying industry, bovine tuberculosis was a constant hazard to humans coming in contact with it.

Remarkable Success Of Bovine T.B. Eradication Campaign, J Shilkin

Journal of the Department of Agriculture, Western Australia, Series 4

Less than 20 years ago Perth dairy herds had the highest T.B. incidence of any Australian capital city and half of the Kalgoorlie cattle had the disease.

Why this was so and how the eradication campaign has reduced the incidence of less than 0.3 per cent, in 128,000 cattle is discussed in this article.

Good Facilities Help T.B. Testing, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

Owner co-operation is needed for the smooth working of the tuberclin testing of cattle, compulsory in the South-West Land Division.

This article describes suitable facilities for the testing and how they operate.

Pamphlet, "The Federal Government And American Indians' Health," February 4, 1950, Fred T. Foard

Usher Burdick Papers

This pamphlet dated February 4, 1950, by Dr. Fred T. Foard, Chief of the Health Branch of the United States Bureau of Indian Affairs, assesses the United States Government's involvement in addressing health needs among indigenous people. Topics include tuberculosis, infant mortality, and appropriations for Indian Health services. There are many handwritten annotations in the pamphlet including a note at the end that reads, "What a pity, please ask our congress to help the American Indians, especially the children." According to a footnote, the contents of this pamphlet were originally published in The Journal of the American Medical Association, …

An Inquiry Into The Influence Of Environment On The Incidence Of Poultry Diseases, L. Van Es, J. F. Olney

Nebraska Agricultural Experiment Station: Historical Research Bulletins

The principal purpose of the investigation reported here was to evaluate, if possible, hygienic measures, and in addition to gather whatever information might become available pertaining to the relation of certain disorders to a given poultry population after its exposure to their specific etiologic factors. The experiments were conducted on a piece of ground upon which poultry had not been maintained for many years, if ever.

The Institutional Missionary And The Sick, E. A. Duemling

Concordia Theological Monthly

Visitation of the sick is one of the most important duties of an institutional missionary. While on earth, Jesus, the Physician, had compassion on the sick and freed them from their ailments, not only physically but also spiritually. Jesus is no longer visibly with us, no longer performing miracles of healing, and sickness is still causing untold agony and misery in the world. It is very sad indeed to see so much pain and suffering, principally in our large hospitals. As long as we are living in a sinful world, there will also be pain, suffering, and, finally, death. There …

Bovine Tuberculosis, L. Van Es

Nebraska Agricultural Experiment Station: Historical Circulars

The development of the present-day knowledge of the tuberculoses of animals is so intimately associated with that pertaining to the human form of the disease that the latter needs to be included in the historical considerations, without which it would be difficult to view any phase of the subject in a comprehensive manner.

An Inquiry Into The Cause Of The Increase Of Tuberculosis Of Swine, L. Van Es, H. M. Martin

Nebraska Agricultural Experiment Station: Historical Research Bulletins

The great increase in the number of swine found to be tuberculous presented a problem, the solution of which appeared to be desirable before adequate control measures could be devised or recommended. In the hope that a solution of the problem may be found this station undertook an investigation and attempted by experimental inquiry to determine the infection type of the tuberculosis associated with the animals which constituted the bulk of the retentions. In view of the apparent increased incidence and spread of tuberculosis among poultry in a large hog raising section, of which Nebraska forms a part, the experimental …

New Haven Hospital The Ninty-Seventh Report Of The General Hospital Society Of Connecticut Year Ending June 30 1924, New Haven Hospital

Yale New Haven Hospital Annual Reports

Report for the year ending June 30, 1924, presented at the Annual Meeting, July 1924.

Bovine Tuberculosis, L. Van Es

Nebraska Agricultural Experiment Station: Historical Circulars

Tuberculosis affects all species of domestic mammals although with different degrees of intensity and frequency. Cattle and swine furnish the greatest number of cases.

New Haven Hospital Ninety-Fourth Annual Report Of The General Hospital Society Of Connecticut For The Year 1921, New Haven Hospital

Yale New Haven Hospital Annual Reports

For the year 1921, presented at the Annual Meeting, October 1921.

New Haven Hospital Eighty-Third Annual Report For The Year 1909, New Haven Hospital

Yale New Haven Hospital Annual Reports

For the year 1909, presented at the Annual Meeting, January 27, 1910.

Bulletin No. 41 - Tuberculosis, F. W. Brewer

UAES Bulletins

One of the most dreaded diseases which afflict the human race is "Tuberculosis." It is also the most fatal, as estimates based on reliable statistics show that at least one out of every eight of mankind die from the disease. It ha~ been a scourge throughout historical time and has been known under the various names of Phthisis, Consumption, Wasting Disease, Tuberculosis, etc. The researches of Professor Koch of Germany in 1881 and since that date have proved that not only Tuberculosis has been produced by the germs of which he was the discoverer, but that Scrofula, Tabes, Hydrocephalus, etc., …