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The Characterization Of Two Differentially Expressed Plasma Proteins In Obese Versus Lean Rats In Two Rodent Models Of Obesity, Roger D. Boggs

Theses, Dissertations and Capstones

Zucker fa and La/N faf rats are widely studied models of genetic obesity and its complications. These two rodent models of obesity were utilized to search for a circulating protein marker for obesity. Plasma samples from both of these models of obesity were collected and analyzed via SDS-PAGE analysis. Two proteins were found which demonstrate differential expression between lean and obese rats. Both proteins demonstrated increased expression in the obese rats compared to the lean. One differentially expressed protein migrated on SDS-PAGE gels at 116 KD while the second migrated at 22 KD compared to molecular weight markers. The 22 …

Obesity And The Development Of Complications Across The Life Span: Is There A Relationship Between Obesity And Poverty, Mildred D. Fennal

University of Kentucky Center for Poverty Research Discussion Paper Series

The purpose of this investigation was to examine the relationship between the development of obesity in children ages five to ten years, and poverty (the socio-economic status of the family). Because of the associated complications of obesity such as heart disease, stroke, diabetes and hypertension, this research aimed to determine if obesity, a precursor of these diseases, was related to poverty.

The rate of the development of hypertension and diabetes in children and young adults has been steadily increasing over the past ten years (Hines, Fishman, Green, 1999). Therefore, there is an urgent need for continued investigation exploring the multiple …

Six-Month Follow-Up Of A Primary Care Managed Weight Loss Program For Overweight And Obese African-American Women, Lee A. Marsh

LSU Master's Theses

Obesity is the number one public health concern in the United States, and is more prevalent in African-American women and those from lower socioeconomic groups. However, many primary care physicians do not feel confident in their ability to assist patients in weight management. Thus the challenge for physicians is to provide patients better assistance with weight management. The purpose of the study was to examine the efficacy of a primary care-managed weight loss program on weight reduction and cardiovascular fitness in overweight/obese women. Participants were randomized to intervention (n=54; Age: 44+12 yrs) or standard care (n=62; Age: 44=12yrs) and followed …

Psychosocial Predictors Of Visceral Adiposity, Paula C. Rhode

LSU Doctoral Dissertations

Psychosocial factors are thought to influence health through primarily direct physiological mechanisms or the alteration of health related behaviors. Three factors hypothesized to negatively impact health include arousal, life stress, and depressive symptomatology. One recent theorist suggests that the interaction between psychological stress and stress hormones on the neuroendocrine system may result in adverse changes to body composition, most notably the increased deposition of visceral adipose tissue (Bjorntorp, 1993). The current study prospectively examined the relationship between self-reported stressful life events, depressive symptoms and trait arousal on the deposition of visceral fat, as measured by computerized tomography (CT). Subjects were …

Mediators Of Weight Loss In An Internet-Based Intervention For African American Adolescent Girls, Marney A. White

LSU Doctoral Dissertations

The primary aim of this study was to assess the process variables involved in a weight loss program for African-American adolescent girls. This internet-based intervention compared a behavioral treatment program to an educational treatment program; it was hypothesized that participants randomized to the behavioral condition would lose more weight at 6 months than those in the educational condition. Several process variables have been identified as affecting success in in vivo weight loss programs for adults and children, including program adherence, self-efficacy, and social support. The current study sought to broaden the understanding of these process variables as they pertain to …

A Path Analysis Of Binge Eating And Obesity In African Americans: Acculturation, Racism, Emotional Distress, Binge Eating, Body Dissatisfaction, Attitudes Towards Obesity, Dietary Restraint, Dietary Fat Intake, And Physical Activity, Joy Rose Kohlmaier

LSU Doctoral Dissertations

The purpose of this study was to test a general stress-related health behavior model as it applied to binge eating and obesity in African Americans using path analysis. Acculturation, racism, emotional distress, binge eating, and obesity were among the variables related to this theory, and included in the model. Other variables that have been implicated in the study of obesity in African Americans were also included, such as; lack of body dissatisfaction, accepting attitudes towards obesity, decreased dietary restraint, increased dietary fat intake and decreased physical activity. The study sample was 325 African Americans, including 187 females with a mean …

Predictors Of Large Women's Satisfaction With Health Care, Virginia M. Koutsouros

PCOM Psychology Dissertations

This cross-sectional observational study identifies specific predictors of large women's satisfaction with health care and participation in preventive care as measured by pelvic screening examinations. A total of 87 large adult women completed a survey, including measures of self-objectification, affective experience, satisfaction with health care, and health care locus of control. Multiple regression analysis was employed to analyze results. The hypotheses of this study were as follows: (1) BMI, self-objectification, negative affect and locus of control will predict satisfaction with medical care; (2) pelvic screening examinations and patient satisfaction with medical care will be positively related (3) self-objectification and negative …

Combining Behavioral And Pharmacological Treatments For Obesity, Suzanne Phelan, Thomas A. Wadden

Kinesiology and Public Health

Weight-loss medications are currently recommended for use only as an adjunct to diet, exercise, and behavior modification. Little, however, is known about the benefits of combining behavioral and pharmacological therapies or about the mechanisms that would make these combined approaches more effective than either used alone. This article reviews the effects of adding pharmacotherapy (i.e., principally sibutramine and orlistat) to a modest program of lifestyle modification. Studies revealed that the addition of medication typically improved short- and long-term weight loss compared with lifestyle modification alone. The best results, however, were obtained when medications were combined with an intensive, group program …

The Obesity Epidemic: Characteristics Of Successful Weight Management Programs And Colorado's Approach, Michele Singer

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Obesity is rapidly growing in the United States with no sign of decreasing with current treatment options available to Americans (1). There are many treatments for obesity, but few are effective. The State of Colorado has numerous community nutrition programs available to its residents ranging from government programs such as universities and state health departments to healthcare providers and volunteer organizations such as the American Heart Association. Current treatments that are available for overweight and obese individuals include commercial programs, popular diet books, Internet programs, and individualized counseling. This paper will discuss different treatments and their efficacy, successful weight loss …

Binge Eating Disorder And Its Relationship To Bulimia Nervosa And Obesity, Lara Schultz Lacaille

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Recent research indicates that 2% to 4% of the population meet diagnostic criteria for the newly proposed binge eating disorder, and that it is much more common (30%) among the treatment-seeking obese. Although recognized as a significant problem, binge eating disorder is l1l not well understood, and there is debate about whether binge eating disorder is a distinct disorder. It has been argued that binge eating disorder is simply a variant or milder form of bulimia nervosa and not a separate and distinct disorder. Researchers have begun to study this population in greater depth in order to assess the characteristics …

Nutrition And Disability, Kathleen Humphries, Meg Traci, Tom Seekins Ph.D., Joyce Brusin, University Of Montana Rural Institute

Health and Wellness

A disability often can be complicated by additional medical, psychological, or environmental problems. Under an emerging framework of health promotion for persons with disabilities, these additional health problems are referred to as secondary conditions (Brandt & Pope, 1997; Marge, 1988; Pope & Tarlov, 1991). Until recently, it was common to conceptualize these ailments as symptomatic of the primary disability; however, it is now presumed that because these conditions can be prevented or managed, they are secondary conditions distinct from the primary disability. Although information on secondary conditions experienced by people with developmental disabilities is limited, the literature does contain descriptions …

Leptin And The Control Of Body Weight And Metabolism: Role For Stearoyl Coa Desaturase-1 And Other Leptin-Regulated Genes In The Liver, Paul Cohen

Student Theses and Dissertations

Leptin is an adipocyte-derived hormone that regulates energy balance, metabolism, and the neuroendocrine response to altered nutrition. Mice lacking leptin (ob/ob) or its receptor (db/db) are massively obese and hyperphagic. They also have increased triglyceride deposits in multiple peripheral organs, including the liver, massively enlarged and steatotic. Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. This response is characterized by weight loss, depletion of lipid from peripheral tissues, and enhanced insulin sensitivity. The mechanisms underlying these actions were largely unknown. This thesis addressed leptin's metabolic effects on the liver, an organ with a critical …

Activity Energy Expenditure And Adiposity Among Black Adults In Nigeria And The United States, Amy Luke, Ramon A. Durazo-Arvizu, Charles N. Rotimi, Helen Iams, Dale A. Schoeller, Abedowale A. Adeyemo, Terrence E. Forrester, Rainford Wilks, Richard S. Cooper

Faculty Publications

Background: The prevalence of obesity is higher among populations in industrialized than in developing countries. Objective: We sought to compare the relations of activity energy expenditure (AEE) with adiposity and weight change in 2 black populations with different levels of obesity. Design: Total daily energy expenditure (TDEE) and resting energy expenditure (REE) were measured and AEE was calculated in 58 Nigerian and 34 US black women and men. Weight was remeasured after ≥1 y in a subset of participants. AEE adjusted for body size and TDEE adjusted for REE were calculated with the use of the residual regression method. The …

Treatment Acceptability For The Prevention Of Obesity And Type 2 Diabetes Mellitus: The Effects Of Ethnicity, Weight, And Genetic Predisposition, Jean Marie Thaw

LSU Doctoral Dissertations

Childhood obesity and its associated health consequences, such as type 2 diabetes mellitus, have dramatically increased over the past 30 years, with the greatest rise in African-American female children and adolescents. Although current prevention efforts show promising results, recent genetic findings may soon expand treatment strategies to include new medications and gene therapies specifically designed to prevent the development of obesity and type 2 diabetes in children. However, little is known about the acceptability of these interventions. The primary aim of this study was to examine the hypothetical impact of genetic knowledge on treatment acceptability in the prevention of childhood …

Fear Of Fatness Among Young Irish Adolescents : Association With Obesity, Reported Iron And Folate Intake, And Dental Health, Anne C. Griffin

Doctoral

OBJECTIVE: To establish the prevalence of fear of fatness (the desire to be thinner) and associated factors, including obesity, reported energy, iron and folate intakes. The difficulties in defining overweight among Irish children and an assessment of dietary and socio-economic factors related to dental caries and also reported in the group. METHODS: A one-year follow up study of 251 healthy schoolchildren at baseline (119 boys and 132 girls; mean age 11 years) attending 7 fee-paying (6 single- and 1-mixed sex) and 8 non-fee-paying (4 single- and 4 mixed-sex) schools in Dublin city center. Assessment of body image perceptions and satisfaction …

The Social Welfare Of Advertising To Children, Dennis D. Crouch

Faculty Publications

The aim of this Comment is to approach the issue of advertising to children through an examination of economic incentives and efficiency. The Comment ultimately makes the claim that televised advertisement of products, such as junk food, directed toward children may be inefficient and tend to decrease social welfare. Although they may be compelling, this paper does not rely on the secondary negative externalities often associated with television, such as the cost of treating diabetes and heart disease. Rather, the inefficiency discussed in the Comment involves the informational qualities of advertising. Advertising directed towards young children can be thought of …

Who's Not Dieting In America And Who Should Be? Results From The 1994-1996 Diet And Health Knowledge Survey (Dhks 1994-1996), Emily York-Crowe

LSU Master's Theses

The rising rates of obesity and overweight are contributing to higher costs for the individual and the nation, both medically and financially. There is a greater need for education and other preventive measures, but in order to tailor such programs effectively to the individuals most in need, it is important to examine the current trends, knowledge, and practices of adults in the United States. Previous research has examined the prevalence rates and practices of specific populations and individuals in limited geographical locations but, due to obvious constraints, few nationally representative samples have been examined. This study analyzed the results of …

Role Of Lipolysis And Lipogenesis In The Development Of Diet-Induced Obesity, Michael John Davies

Theses and Dissertations in Biomedical Sciences

Obesity is an increasingly common public health problem with approximately one-half of the American adult population overweight and one-quarter considered obese. This alarming trend has led researchers to determine potential causative factors of excess weight gain in humans. However, it is difficult to discern whether perturbations that result in obesity are the cause or simply the result of the obese state. Diet-induced obesity is one of the animal models that allow researchers to address temporal issues. Our laboratory utilizes a diet-induced obesity model in which Sprague-Dawley rats are placed on a purified moderately high fat diet and ultimately diverge into …

Weight Discrimination: A Multidisciplinary Analysis, Cheryl Maranto, Ann Fraedrich Stenoien

Management Faculty Research and Publications

Protection against obesity discrimination is extremely limited under the Americans with Disabilities Act (ADA). No obese plaintiff has won using the actual disability theory, but a few have won under the perceived disability theory. Weight-related appearance standards are legal. We estimate weight-based wage penalties for young men and women. We find that mildly obese (20% over standard weight) white women experience greater wage penalties than black men experience for weight that is 100% over standard weight. Men do not experience wage penalties until their weight exceeds standard weight by over 100 lb. A gender-plus analysis under Title VII is more …

Obesity: Environment Vs. Genetics, Kammi Marie Reeder Hansen

Undergraduate Honors Capstone Projects

The prevalence of overweight and obese individuals is rising. Between 1980 and 1990 there was an 8% increase in the prevalence of obesity. Obesity is associated with many diseases such as hypertension, type 2 diabetes, heart disease and cancer. Over $39 billion dollars is spent annually on the illnesses associated with obesity. Our American culture has been blamed for the rise in obesity, yet there are obviously many people living in the American culture that are not obese. Researchers have turned to genetics to explain this phenomenon. This article will examine the many environmental factors that contribute to obesity and …

Mortality And Optimal Body Mass Index In A Sample Of The Us Population, Ramón A. Durazo-Arvizu, Daniel L. Mcgee, Richard S. Cooper, Youlian Liao, Amy Luke

Faculty Publications

In this paper, the authors model the nonmonotonic relation between body mass index (BMI) (weight (kg)/height2 (m2)) and mortality in 13,242 black and white participants in the NHANES I Epidemiologic Follow-up Study in order to estimate the BMI at which minimum mortality occurs. The BMI of minimum mortality was 27.1 for black men (95% confidence interval (CI) 24.8-29.4), 26.8 for black women (95% CI 24.7-28.9) 24.8 for white men (95% CI 23.8- 25.9), and 24.3 for white women (95% CI 23.3-25.4). Each confidence interval included the group average. Analyses conducted by smoking status and after exclusion of persons with baseline …

Leptin And Body Composition Of Nigerians, Jamaicans, And Us Blacks, Amy H. Luke, Charles N. Rotimi, Richard S. Cooper, Andrew E. Long, Terrence E. Forrester, Rainford Wilks, Franklyn I. Bennett, Olufemi Ogunbiyi, Joyce A. Compton, Ronald R. Bowsher

Faculty Publications

The role of leptin in humans remains controversial. Leptin concentrations are highly correlated with body fat stores. We tested whether or not this relation was consistent across the range of body composition encompassing the lean as well as the obese. Individuals participating in community-based comparative research in Nigeria (n = 363), Jamaica (n = 372), and the United States (Maywood, IL; n = 699) had their plasma leptin concentrations and body compositions (with bioelectrical impedance analysis) measured. All participants identified themselves as being black. Body mass index (in kg/m2) ranged from 14 to 62. Large differences in mean plasma leptin …

Increasing Prevalence Of Overweight Among Us Low-Income Preschool Children: The Centers For Disease Control And Prevention Pediatric Nutrition Surveillance, 1983 To 1995, Zuguo Mei, Kelley S. Scanlon, Laurence M. Grummer-Strawn, David S. Freedman, Ray Yip, Frederick L. Trowbridge

United States Public Health Resources

Objective. To determine whether the prevalence of overweight in preschool children has increased among the US low-income population.

Design. Analysis using weight-for-height percentiles of surveillance data adjusted for age, sex, and race or ethnicity.

Setting. Data from 18 states and the District of Columbia were examined.

Subjects. Low-income children <5 years of age who were included in the Centers for Disease Control and Prevention Pediatric Nutrition Surveillance System.

Results. The prevalence of overweight increased from 18.6% in 1983 to 21.6% in 1995 based on the 85th percentile cutoff point for weight-for-height, and from 8.5% to 10.2% for the same period based on the 95th percentile cutoff point. Analyses by single age, sex, and race …

Potential Role Of Tnfα And Lipoprotein Lipase As Candidate Genes For Obesity, Philip A. Kern

Clinical and Translational Science Faculty Publications

To maintain body weight, metabolic efficiency was promoted during evolution; two candidate genes for body weight regulation are lipoprotein lipase (LPL) and tumor necrosis factor-α [TNFα). Human fat cells do not synthesize lipid, but rely on LPL-mediated plasma triglyceride hydrolysis. Adipose LPL is elevated in obesity. Following weight loss, LPL is elevated further, suggesting attempts to maintain lipid stores during fasting and to replenish lipid stores during refeeding. Muscle LPL is regulated inversely to adipose LPL. Thus, an increased adipose/muscle LPL ratio would partition dietary lipid into adipose tissue and would explain some of the variability in weight gain when …

Leptin Concentration In Women Is Influenced By Regional Distribution Of Adipose Tissue, Franklyn I. Bennett, Norma Mcfarlane-Anderson, Rainford Wilks, Amy Luke, Richard S. Cooper, Terrence E. Forrester

Faculty Publications

Leptin concentrations in humans are increased with obesity, and women have higher leptin concentrations than men. This sex difference reflects the greater fat mass of women. However, there is evidence that factors other than the size of the adipose tissue mass contribute to serum leptin concentrations. This study was undertaken to determine whether anthropometric factors influenced leptin concentrations in our population. Leptin concentrations were measured in 375 persons from a population study of hypertension and diabetes for whom body-composition data (bioelectrical impedance analysis and anthropometry) were available. Serum leptin concentrations were more than four times higher in women than in …

A Comparison Of Variables Affecting Motivation For Weight Loss In Overweight And Obese Adults Utilizing A Medication Assisted Weight Loss Program, Teresann Nickle

Theses and Dissertations

No abstract provided.

The Relationship Between Diet, Activity, And Other Factors, And Postpartum Weight Change By Race, Debra J. Boardley, Roger G. Sargent, Ann L. Coker, James R. Hussey, Patricia A. Sharpe

CRVAW Faculty Journal Articles

Objective: To identify the impact of dietary intake and activity level on postpartum weight change.

Methods: White (n = 121) and black (n = 224) women, 7-12 months postpartum, participating in the Special Supplemental Feeding Program for Women, Infants, and Children were assessed for dietary intake, activity level, body weight, and other maternal characteristics.

Results: For both black and white women, the most important variables in predicting postpartum weight loss were pre-pregnancy weight, gestational weight gain, parity, and prenatal exercise. After these factors were controlled, race predicted that black women retained 6.4 lb more than white women. These results may …

The Association Between Mood States And Physical Activity In Postmenopausal Obese, Sedentary Women, Robert Albert Carels, Bonnie Berger, Lynn Darby

Psychology Faculty Publications

Mood states influence evaluative judgments that can affect the decision to exercise or to continue to exercise.

Program To Decrease Obesity Of Mentally Retarded Adults, Joye Jeffries Pugh

Abraham S. Fischler College of Education ETD Archive

This report explains a program for decreasing obesity of mentally retarded adults served by a mental retardation service center in a southern rural community. Problems originally noticed included enormous body weights of clients, obesity-related diseases, a lack of exercise programming, and failure to participate in Special Olympics.

An analysis of the clients' Individual Physical Data Bases revealed body weights 20X or more over the average for a person's age, build, sex, and height. According to the client medical reports, 50% of the obese clients suffered from medical disorders created by their obesity. A review of the Individual Service Plans indicated …

The Dynamics Between Obesity And Spirituality , Jeffrey Lee Spicer

ATS Dissertations

No abstract provided.