Digital Commons Network^™

Multiethnic Genome-Wide Meta-Analysis Of Ectopic Fat Depots Identifies Loci Associated With Adipocyte Development And Differentiation, Audrey Y. Chu, Xuan Deng, Virginia A. Fisher, Alexander Drong, Yang Zhang, Mary F. Feitosa, Ching-Ti Liu, Olivia Weeks, Audrey C. Choh, Qing Duan, Thomas D. Dyer

School of Medicine Publications

Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men for six ectopic fat traits in European, African, Hispanic, and Chinese ancestry populations, with and without sex stratification. In total, 7 new loci were identified in association with ectopic fat traits (ATXN1, UBE2E2, EBF1, RREB1, GSDMB, GRAMD3 and ENSA; PATXN1 and UBE2E2 …

Influence Of Media Messages On Obesity And Health Perceptions Among African American Women, Carolyn Grant

Walden Dissertations and Doctoral Studies

African American women have the highest prevalence of overweight and obesity in the United States, thus increasing their risks for chronic diseases. Their understanding of their health status and response to it could be triggered by messages in the media, yet few researchers have examined this topic with African American women. The purpose of this phenomenological study was to explore how advertisement and editorial content in media contributed to perceptions African American women have about overweight and obesity. Following the theoretical foundation of the social cognitive theory, the research questions explored what messages study participants encountered and which messages prompted …

Sarcopenia: Prevalence, And Impact On Operative And Oncologic Outcomes In The Multimodal Management Of Locally Advanced Esophageal Cancer, Jessie Elliott, Suzanne Doyle, Conor Murphy, Sinead King, Emer Guinan, Peter Beddy, Narayanasamy Ravi, John Reynolds

Articles

Objective: The aim of this article was to study the prevalence and significance of sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes.

Summary of background data: Sarcopenia in cancer may confer negative outcomes, but its prevalence and impact on modern multimodal regimens for LAEC have not been systematically studied.

Methods: Two hundred fifty-two consecutive patients were studied. Lean body mass (LBM), skeletal muscle index (SMI), and fat mass (FM) were determined pre-treatment, preoperatively, and 1 year postoperatively. Sarcopenia was defined by computed tomography (CT) at L3 …

Overweight And Obesity In A Sample Of Primary School Children In Baghdad, Faris Al Lami, Riyadh Alredainy

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Obesity is one of the most serious public health problems of the 21st century, that has many serious long-term consequences for health. The prevalence of childhood obesity has been increasing at worrying rates across the globe. OBJECTIVE: To measure the prevalence and identify potential risk factors of overweight and obesity among a sample of primary school children in Baghdad, Iraq. METHODS: This cross-sectional study was conducted on a random sample of 10 primary schools from different localities of Baghdad, followed by a systematic random sample of 620 children aged 10 years or more of both sexes. A questionnaire …

The Effects Of The Implementation Of Green Carts On New Yorkers' Bmi, Ana L. Pacheco

Theses and Dissertations

This study focuses on the Green Cart Initiative implemented by the New York City Mayor’s Office of Food Policy. The Initiative was implemented to bring fresh fruits and vegetables in a fast, cheap, and efficient way to neighborhoods considered food deserts and areas with high rates of obesity.

“Mexico, Public Policy And Obesity In A Global Context”, Daniela Carina Bermudez

Master's Theses

Mexico has one of the most obese populations in the world. A country known for its diversity of rich flavorful food is drowning in low nutritional food products. This thesis examines Mexico’s obesity epidemic within the larger global context of international economic trade policies, public policies and Mexico’s health policies. The key research questions are 1) why is there an obesity epidemic in Mexico? and 2) what remedies should Mexico implement to control it? This thesis contributes to a viable policy strategy for the Mexican government to control and prevent the further increase of this obesity epidemic. Reviewing both the …

Role Of A Plausible Nuisance Contributor In The Declining Obesity-Mortality Risks Over Time., Tapan Mehta, Nicholas M. Pajewski, Scott W. Keith, Kevin Fontaine, David B. Allison

Department of Pharmacology and Experimental Therapeutics Faculty Papers

CONTEXT: Recent analyses of epidemiological data including the National Health and Nutrition Examination Survey (NHANES) have suggested that the harmful effects of obesity may have decreased over calendar time. The shifting BMI distribution over time coupled with the application of fixed broad BMI categories in these analyses could be a plausible "nuisance contributor" to this observed change in the obesity-associated mortality over calendar time.

OBJECTIVE: To evaluate the extent to which observed temporal changes in the obesity-mortality association may be due to a shifting population distribution for body mass index (BMI), coupled with analyses based on static, broad BMI categories. …

Spatial Distribution Of High Obesity Rates In South Carolina, Tom Bennett

Earth and Environmental Sciences Presentations

In 2015, the rate of adult obesity in South Carolina was nearly 32%, which places South Carolina as the 13th worst state when it comes to the prevalence of adult obesity. Along with overall rates of adult obesity, South Carolina has the 8th highest high school student obesity rate with 16.3% of high school students being obese. These statistics are troubling because obesity is a primary cause of Type II Diabetes, high blood pressure, and many other negative health effects. These health care issues then affect supply and demand for health care, advertising, physical exercise, and many other market segments, …

Metabolic Alteration Induced By Time Restricted Feeding At Different Points In The Circadian Cycle, Laura Brooks Crone

Electronic Theses and Dissertations Archive

The goal was to determine if a high fat diet given in a time restricted fashion can protect against obesity and inflammatory mediators. 12 week old C57BL/6 male mice were assigned to either a standard chow diet or a diet containing 45% fat. The high fat diet was provided ad libitum or in a time restricted fashion, either during the first of the second half of the active phase for 8 weeks. Time restricted meal intake reduced body mass gain, adiposity, glucose intolerance and cholesterol levels in mice fed a high fat diet. Mice fed a high fat diet, even …

The Unfortunate Role Of Farm Subsidies As A Stimulus For Inequality And Obesity, Neil M. Browne, Facundo Bouzat, Justin Rex, Joseph Seipel

Economics Faculty Publications

Governmental expenditures are directed at a particular objective, but their effects have consequences far beyond the named target of the expenditures. Specific farm subsidies, for example, encourage consumption of particular foods by reducing the costs of producing these foods. To what extent do these subsidies affect the American obesity epidemic? How do the subsidies create disparate negative effects on those in poverty? Exploring these questions stimulates us to take greater care when designing legislation to take a broader look at the stakeholders affected by any particular governmental expenditure.

Harnessing Redox Regulation Of Ptp1b: A Novel Path To Therapeutic Design, Ioana Rus Rus

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Protein tyrosine phosphatase 1B (PTP1B) is an important negative regulator of signaling by the insulin and leptin receptors. PTP1B-null mice are sensitized to insulin and resistant to diet-induced obesity, making PTP1B a prized target in the pharmaceutical industry for therapeutic intervention in type two diabetes and obesity. Efforts to develop inhibitors of PTP1B focused on the active site pocket; however, those efforts have been hindered by poor oral bioavailability of the compounds. Our lab has exploited the conformational changes associated with redox regulation of PTP1B to devise an alternative method of inhibiting the enzyme. Reactive oxygen species, generated in response …

Effects Of Obesity In Elementary School Children After No Child Left Behind (Nclb), Victoria L. Moore

Capstone Projects and Master's Theses

Ever since No Child Left Behind (NCLB) legislation became adopted into our school system, students’ physical health has suffered. Recently, the number of unhealthy children has grown. One in three children are classified as overweight or obese. This senior capstone project demonstrates the causes and effects of such an issue in regards to both physical education and nutritional education in elementary schools in the tri-county areas of Monterey, Salinas, and Santa Clara counties. The results from twenty-seven survey results and one interview suggest that most teachers feel that there is a need for daily physical education and nutritional education should …

Multi-Level Predictors Of Obesity And Diet In Multi-Ethnic Populations, Tali Elfassy

Open Access Dissertations

The obesity epidemic in the United States is a major public health issue. Poor socio-economic conditions such as poverty or living under financial stress may adversely influence health outcomes such as obesity, and often disproportionately impact ethnic minority populations. Further, individuals living in poverty are often exposed to environments that promote unhealthy diet and obesity. Such obesogenic environments are characterized by increased exposure to foods high in sodium and low in potassium which may also be independently associated with obesity. Yet these associations have not been adequately explored, especially among ethnic minority populations. The current dissertation seeks to explore: 1) …

A Behavioral Economic Analysis Of Obesity Among College Women, Holly Ann Keating

Electronic Theses and Dissertations Archive

Overweight and obesity are particularly saient concerns for adolescents and young adults, the age group with the greatest risk of weight gain each year. The present study examined differences in behavioral economic measures of food reinforcement and delay discounting among normal weight women compared to overweight and obese adult women. Effects of symptoms of depression and ethnicity were also examined. Young adult women were given a variety of questionnaires. The current study hypothesized that overweight and obese women would rate food images as being more pleasant, discount money more steeply, have higher food-related reinforcement, and higher demand for food. Overweight …

A Review Of The Growth Of The Fast Food Industry In China And Its Potential Impact On Obesity, Youfa Wang, Liang Wang, Hong Xue, Weidong Qu

ETSU Faculty Works

The fast-food (FF) industry and obesity rates have rapidly increased in China. This study examined the FF industry growth in China, key factors contributing to the growth, and the association between FF consumption (FFC) and obesity. We collected related data from multiple sources and conducted analysis including linear regression analysis on the increase in FF revenue. It was found that FF industry in China is large, with over two million FF facilities. Its total revenue (in million US$) increased from 10,464 in 1999 to 94,218 in 2013, and by 13% annually since 2008. Increased income, urbanization, busier lifestyle, speedy FF …

Autism Spectrum Disorder And The Child's Weight–Related Behaviors: A Parents' Perspective, Michele Polfuss, Norah L. Johnson, Susan A. Bonis, Fallon Apollon, Kathleen Sawin

College of Nursing Faculty Research and Publications

Purpose

To explore parent perspectives of how the attributes of their child's autism spectrum disorder(ASD) impact nutrition, physical activity, screen time behaviors and risk for obesity. Secondarily, we examined the parent's perception of the healthcare providers (HCP) influence on these weight-related behaviors.

Design and method

We conducted and audio-recorded telephone interviews with parents of children with ASD (n = 8) using a structured question guide. Data were transcribed and thematic analysis was conducted. Issues surrounding weight-related behaviors and parental strategies used were reported.

Results

Two overarching themes with eight subthemes emerged: (1) Challenges related to features of ASD (subthemes included …

Prevalence Of And Risk Factors For Adolescent Obesity In Tennessee Using The 2010 Youth Risk Behavior Survey (Yrbs) Data: An Analysis Using Weighted Hierarchical Logistic Regression, Shimin Zheng, Nicole Holt, Jodi L. Southerland, Yan Cao, Trevor Taylor, Deborah L. Slawson, Mark Bloodworth

ETSU Faculty Works

Background: The rate of adolescent overweight and obesity has more than quadrupled over the past few decades, and has become a major public health problem [1]. In 2011, 55% of 12-19 year olds in the United States (U.S.) were overweight or obese [2]. Adolescence is a pivotal time in which many health risk behaviors such as tobacco, alcohol, and drug use are initiated. Such health risk behaviors have been significantly associated with overweight and obesity among adolescents.

Objective: The purpose of this study is to evaluate the relationship between obesity and the health risk behaviors most commonly associated with premature …

Impact Of Different Fecal Processing Methods On Assessments Of Bacterial Diversity In The Human Intestine, Yu Hsin Hsieh, Courtney M. Peterson, Anne Raggio, Michael J. Keenan, Roy J. Martin, Eric Ravussin, Maria L. Marco

Faculty Publications

The intestinal microbiota are integral to understanding the relationships between nutrition and health. Therefore, fecal sampling and processing protocols for metagenomic surveys should be sufficiently robust, accurate, and reliable to identify the microorganisms present. We investigated the use of different fecal preparation methods on the bacterial community structures identified in human stools. Complete stools were collected from six healthy individuals and processed according to the following methods: (i) randomly sampled fresh stool, (ii) fresh stool homogenized in a blender for 2 min, (iii) randomly sampled frozen stool, and (iv) frozen stool homogenized in a blender for 2 min, or (v) …

Assessing Feasibility And Readiness To Address Obesity Through Policy In American Indian Reservations, Valarie Blue Bird Jernigan, Gail Boe, Carolyn Noonan, Leslie Carroll, Dedra Buchwald

Journal of Health Disparities Research and Practice

The Institute of Medicine and Centers for Disease Control and Prevention (CDC) have identified policy and environmental strategies as critical to the prevention and control of obesity. However such strategies are rare in American Indian communities despite significant obesity-related disparities. Tribal policymaking processes differ by tribal nation and are often poorly understood by researchers and public health practitioners, hindering the dissemination, implementation, and successful scale-up of evidence-base obesity strategies in tribal communities. To address these gaps in knowledge we surveyed 138 diverse stakeholders in two American Indian reservations to assess the feasibility of and readiness to implement CDC-recommended obesity policy …

Omic Paradigms Enhance Interface Between Periodontitis Pathogenesis And Metabolic Disorder, Hong-Duck Kim, Kiran Naiyeam, Jae-Hyeon Cho, Diane E. Heck

NYMC Faculty Publications

No abstract provided.

Design, Implementation And Evaluation Of A Game-Based Intervention Targeting Latino Children For Improving Obesity Outcomes, Ashish Amresh, Rahul Salla, Madhumita Sinha, Rebecca Birr

Publications

This paper presents the design, implementation and evaluation of a hybrid clinic plus home based intervention targeting Latino children to improve obesity outcomes. The intervention applies motivational game based learning and behavior change theories during design. Latino American children are the main target group for this study as they have significantly high obesity rates due to socio-economic conditions and lack of awareness. There have been several interventions that have targeted game based strategies in the clinic to promote health outcomes and some have even targeted obesity problems, however to our knowledge this is the first effort that adds an inhome …

Molecular Mechanisms Of Obesity-Induced Osteoporosis And Muscle Atrophy, Bipradas Roy, Mary E. Curtis, Letimicia S. Fears, Samuel N. Nahashon, Hugh M. Fentress

Biology Faculty Research

Obesity and osteoporosis are two alarming health disorders prominent among middle and old age populations, and the numbers of those affected by these two disorders are increasing. It is estimated that more than 600 million adults are obese and over 200 million people have osteoporosis worldwide. Interestingly, both of these abnormalities share some common features including a genetic predisposition, and a common origin: bone marrow mesenchymal stromal cells. Obesity is characterized by the expression of leptin, adiponectin, interleukin 6 (IL-6), interleukin 10 (IL-10), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), macrophage colony stimulating factor (M-CSF), growth hormone (GH), parathyroid …

Wnt5a-Jnk Regulation Of Vascular Insulin Resistance In Human Obesity, Melissa G. Farb, Shakun Karki, Song-Young Park, Samantha M. Saggese, Brian Carmine, Donald T. Hess, Caroline Apovian, Jessica L. Fetterman, Rosa Breton-Romero, Naomi M. Hamburg, Jose J. Fuster, Maria A. Zuriaga, Kenneth Walsh, Noyan Gokce

Health and Kinesiology Faculty Publications

Obesity is associated with the development of vascular insulin resistance; however, pathophysiological mechanisms are poorly understood. We sought to investigate the role of WNT5A-JNK in the regulation of insulin-mediated vasodilator responses in human adipose tissue arterioles prone to endothelial dysfunction. In 43 severely obese (BMI 44±11 kg/m2) and five metabolically normal non-obese (BMI 26±2 kg/m2) subjects, we isolated arterioles from subcutaneous and visceral fat during planned surgeries. Using videomicroscopy, we examined insulin-mediated, endothelium-dependent vasodilator responses and characterized adipose tissue gene and protein expression using real-time polymerase chain reaction and Western blot analyses. Immunofluorescence was used to quantify endothelial nitric oxide …

An Updated Mini Review Of Vitamin D And Obesity: Adipogenesis And Inflammation State, Zujaja Tul Noor Hamid Mehmood, Dimitrios Papandreou

All Works

© 2016 Zujaja-Tul-Noor Hamid Mehmood, Dimitrios Papandreou. Vitamin D related research continues to expand and theorise regarding its involvement in obesity, as both hypovitaminosis D and obesity strike in pandemic proportions. Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body. Due to this characteristic, it is potentially linked to obesity, which is a state of inflammation involving the release of cytokines from adipose tissue, and exerting stress on other organs in a state of positive energy balance. Research trials in the past couple of years and …

Metabolic Syndrome: Differences For Asian Americans Is In Their Percentage Of Body Fat, Patricia Alpert, Diane L. Thomason

Asian/Pacific Island Nursing Journal

Asian Americans are not frequently thought of as being obese or overweight yet some of the Asian American subgroups have a disproportionate risk for cardiovascular disease and type 2 diabetes mellitus. Although the standardized body mass index (BMI) assessment is an adequate tool for reporting secular prevalence trends for overweight/obesity across populations, it falls short in accuracy when assessing Asian Americans. In recent years more has been written about the re-evaluation of BMI cut points for normal weight, overweight, or obese Asian Americans. Additionally, the waist circumference norm was modified to indicate a smaller waist size is a risk for …

Methylation Of Socs3 Is Inversely Associated With Metabolic Syndrome In An Epigenome-Wide Association Study Of Obesity, Omar Ali, Diana Cerjak, Jack W. Kent Jr, Roland James, John Blangero, Melanie A. Carless, Yi Zhang

School of Medicine Publications

Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (Pα=0.05 = 1.31 × 10-7) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a …

Household, Psychosocial, And Individual-Level Factors Associated With Fruit, Vegetable, And Fiber Intake Among Low-Income Urban African American Youth., Angela Cristina Bizzotto Trude, Anna Yevgenyevna Kharmats, Kristen Marie Hurley, Elizabeth Anderson Steeves, Sameera A Talegawkar, Joel Gittelsohn

Exercise and Nutrition Sciences Faculty Publications

BACKGROUND: Childhood obesity, one of the greatest challenges to public health, disproportionately affects low-income urban minority populations. Fruits and vegetables (FV) are nutrient dense foods that may be inversely associated with excessive weight gain. We aimed to identify the individual characteristic, psychosocial, and household factors influencing FV and fiber consumption in low-income African-American (AA) youth in Baltimore, MD.

METHODS: Cross-sectional analysis of data collected from 285 low-income AA caregiver-youth (age range: 10-14 y) dyads participating in the baseline evaluation of the B'More Healthy Communities for Kids obesity prevention trial. The Kid's Block FFQ was used to estimate daily intakes of …

An Intervention To Promote Navajo Gardening, Nutrition, And Community Wellness, Sonia Avitia, Mark C. Bauer, Phd, Linda Garcia

Journal of Health Disparities Research and Practice

The rates of diabetes and obesity in Navajo communities are higher than national rates. A healthy diet of fresh fruits and vegetables will help to prevent and reduce such rates. So the project focuses on promoting gardening to make vegetables and fruits more accessible at the comfort of one’s own home. Previous research in this area shows that gardeners consume 2 more servings of fruits and vegetables than nongardeners. Thirty participants were recruited by flyer distribution at chapter houses, senior centers, and community centers, from four Navajo targeted areas: Shiprock, NM; Tsaile, AZ; Lukachukai, AZ, and Hogback, NM. With the …

Perceived Self-Efficacy And Financial Incentives: Factors Affecting Health Behavior And Body Weight In Individuals With Overweight And Obesity, Julia Ann Simon

Master's Theses

No abstract provided.

Decomposing Trends In Adult Body Mass Index, Obesity, And Morbid Obesity, 1971-2012, Ashley Wendell Kranjac, Robert L. Wagmiller

Sociology Faculty Articles and Research

Trends in adult obesity have been used to motivate key public health policies in the United States. While these analyses provide important insights into the broad historical contours of the obesity epidemic in the U.S., they shed less light on the proximate mechanisms that have generated these changes and that will ultimately determine the long-term course and pace of change in obesity rates. We used data from the National Health and Nutrition Examination Survey (NHANES), Glenn Firebaugh's linear decomposition technique, and Kitagawa's algebraic decomposition method to decompose change in body mass index (BMI), obesity, and morbid obesity from 1971 through …