Digital Commons Network^™

Genetic Association Analysis Of Polymorphisms In Psd3 Gene With Obesity, Type 2 Diabetes, And Hdl Cholesterol, Shaoqing Gong, Chun Xu, Liang Wang, Ying Liu, Daniel Owusu, Beth A. Bailey, Yujing Li, Kesheng Wang

Health & Biomedical Sciences Faculty Publications

Highlights

• First study of PSD3 gene with obesity, type 2 diabetes and HDL cholesterol.

• Identified 23 SNPs associated with obesity with p < 0.05 in gene discovery.

• 20 SNPs were associated with obesity in meta-analysis of two samples.

• 6 SNPs associated with type 2 diabetes and 11 associated with HDL.

• Findings offer new insights into the pathogenesis of obesity and diabetes.

Abstract

Background

The pleckstrin and Sec7 domain-containing 3 (PSD3) gene has been linked to immune diseases. We examined whether the genetic variants within the PSD3 gene are associated with obesity, type 2 diabetes (T2D), and high-density lipoprotein (HDL) cholesterol level.

Methods

Multiple …

Evaluation Of A Primary Care Weight Loss Program, Callie Chiroff, Christine Shaw, Kristin Haglund, Susan Breakwell

College of Nursing Faculty Research and Publications

Nurse practitioners at a primary care clinic established a weight loss program to address high obesity rates among their African American patients. Interviews and a retrospective chart review were used to evaluate the weight loss program. Number of appointments was the only significant predictor of weight loss, and there was a strong positive correlation between total number of appointments and weight loss. The overall view of the program was positive. This description and evaluation of the program may be useful to nurse practitioners seeking to develop an individualized effective weight loss intervention for African Americans within a primary care setting.

Clinical Significance Of A False Positive Glucose Challenge Test In Patients With A High Body Mass Index, A Borja, M Moretti, Nisha Lakhi

NYMC Faculty Publications

OBJECTIVE: To determine if there is an increased maternal or neonatal morbidity in overweight and obese patients with a false positive glucose challenge test (GCT). METHODS: Patients with a body mass index (BMI) >/=25.0 at registration were included in this prospective 36-month study. The study cohort consisted of patients with a false positive (FP) GCT, with two comparison cohorts: those with a (1) screen negative (SN) GCT result and (2) true positive (TP) GCT result. Risks were reported as odd ratios with 95% confidence intervals, with a P/=4000 g in the FP cohort, but this fell short of reaching statistical …

Evaluating The Effectiveness Of Goal Setting And Textual Feedback Using A Wearable Technology For Increasing Running Distance, Michael Zarate

USF Tampa Graduate Theses and Dissertations

Obesity is a growing problem that has life-threatening health consequences. One way to combat obesity is by increasing physical activity levels, which has been a focus of recent applied behavioral research. The purpose of this study was to evaluate the effectiveness of goal setting and textual feedback without social support to increase physical activity, specifically weekly running distance. A multiple-baseline across participants design was employed with four participants using a Fitbit Flex accelerometer to collect two physical activity measures, intense steps and distance. Results showed a significant increase in weekly running distance for two out of four participants following the …

Implementation Of Clinical Research Trials Using Web-Based And Mobile Devices: Challenges And Solutions., Roy Eagleson, Luis Altamirano-Diaz, Alex Mcinnis, Eva Welisch, Stefanie De Jesus, Harry Prapavessis, Meghan Rombeek, Jamie A Seabrook, Teresa Park, Kambiz Norozi

Paediatrics Publications

BACKGROUND: With the increasing implementation of web-based, mobile health interventions in clinical trials, it is crucial for researchers to address the security and privacy concerns of patient information according to high ethical standards. The full process of meeting these standards is often made more complicated due to the use of internet-based technology and smartphones for treatment, telecommunication, and data collection; however, this process is not well-documented in the literature.

RESULTS: The Smart Heart Trial is a single-arm feasibility study that is currently assessing the effects of a web-based, mobile lifestyle intervention for overweight and obese children and youth with congenital …

Precipitating Factors Influencing Obesity Rates In Indiana, Jeffrey Allen

Journal of the Indiana Academy of the Social Sciences

Nearly two-thirds of the American population is now overweight, and the rate of obesity has doubled since the early 1960s. The state of Indiana has elected to forgo Medicaid expansion available through the Affordable Care Act of 2010 (ACA), which includes funding specific to obesity and obesity-related comorbidities. Utilizing the Robert Wood Johnson Foundation 2014 Health Statistics, causative obesity factors found in current research literature is examined for Indiana’s 92 counties. The variables are examined to determine significant correlation with adult levels of obesity. The significant variables (smoking, unemployment levels, physical inactivity) found in the correlation are then placed in …

High-Fat Feeding Does Not Disrupt Daily Rhythms In Female Mice Because Of Protection By Ovarian Hormones, Brian T. Palmisano, John M. Stafford, Julie S. Pendergast

Biology Faculty Publications

Obesity in women is increased by the loss of circulating estrogen after menopause. Shift work, which disrupts circadian rhythms, also increases the risk for obesity. It is not known whether ovarian hormones interact with the circadian system to protect females from obesity. During high-fat feeding, male C57BL/6J mice develop profound obesity and disruption of daily rhythms. Since C57BL/6J female mice did not develop diet-induced obesity (during 8 weeks of high-fat feeding), we first determined if daily rhythms in female mice were resistant to disruption from high-fat diet. We fed female PERIOD2:LUCIFERASE mice 45% high-fat diet for 1 week and measured …

Sex-Dependent Effects Of Ho-1 Deletion From Adipocytes In Mice, Peter Hosick, Mary Frances Weeks, Michael W. Hankins, Kyle H. Moore, David E. Stec

Department of Exercise Science and Physical Education Scholarship and Creative Works

Induction of heme oxygenase-1 (HO-1) has been demonstrated to decrease body weight and improve insulin sensitivity in several models of obesity in rodents. To further study the role of HO-1 in adipose tissue, we created an adipose-specific HO-1 knockout mouse model. Male and female mice were fed either a control or a high-fat diet for 30 weeks. Body weights were measured weekly and body composition, fasting blood glucose and insulin levels were determined every six weeks. Adipocyte-specific knockout of HO-1 had no significant effect on body weight in mice fed a high-fat diet but increased body weight in female mice …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Students compete in fourth annual 3 day Startup on Campus
• University study shows number of obese adults trying to lose weight is decreasing
• Graduate student's folk pottery exhibit on display through March 31

Life After Nbc’S “The Biggest Loser”: The Experiences And Perspectives Of Former Reality Tv Contestants, Darren D. Moore, Clinton Cooper, Toiya Williams, Kai Zwierstra

The Qualitative Report

Utilizing Qualitative Description influenced by aspects of phenomenology, we conducted fifteen open-ended, semi-structured interviews with former contestants of NBC’s “The Biggest Loser.” The purpose of the study was to explore experiences of significant weight loss. We focused on challenges, emotional well-being, and relational dynamics of contestants transitioning through their weight loss journeys, which included what happened after the show was completed. Further, we analyzed perspectives regarding the utility of Marriage and Family Therapists (MFTs) in working with this population. In the study, three themes emerged which included: (1) Living at the ranch: It’s reality TV, not reality; (2) After the …

Pre-Training Muscle Characteristics Of Subjects Who Are Obese Determine How Well Exercise Training Will Improve Their Insulin Responsiveness, Charles A. Stuart, Michelle L. Lee, Mark A. South, Mary E. A. Howell, Brian M. Cartwright, Michael W. Ramsey, Michael H. Stone

ETSU Faculty Works

Pre-training muscle characteristics of subjects who are obese determine how well exercise training will improve their insulin responsiveness. J Strength Cond Res 31(3): 798–808, 2017—Only half of prediabetic subjects who are obese who underwent exercise training without weight loss increased their insulin responsiveness. We hypothesized that those who improved their insulin responsiveness might have pretraining characteristics favoring a positive response to exercise training. Thirty nondiabetic subjects who were obese volunteered for 8 weeks of either strength training or endurance training. During training, subjects increased their caloric intake to prevent weight loss. Insulin responsiveness by euglycemic clamps and muscle fiber composition, …

Obesity And Learned Eating Behavior: A Review Of First Bite: How We Learn To Eat, Winnie Eke

Journal of Social, Behavioral, and Health Sciences

Bee Wilson's book, First Bite: How we learn to eat is reviewed.

The Relationship Of Visceral Adipose Tissue With Markers Of Energy Homeostasis Following Weight-Loss, Marcus A. Breden, Bryan K. Smith, Matthew P. Harris, Brooke Burgess, Adam Gloeckner, Melody D. Phillips, Joshua S. Wooten

International Journal of Exercise Science: Conference Proceedings

Excess levels of adipose tissue, in particular visceral adipose tissue (VAT), is closely associated with the metabolic syndrome and dysregulation of energy homeostasis. It is hypothesized that leptin resistance results in overconsumption of calories and reduced satiety. Recently, brain derived neurotrophic factor (BDNF), beyond functioning in learning and memory, is shown to play a role in energy homeostasis via its positive satiety effects on the hypothalamus. However, it remains to be elucidated how changes in visceral adipose tissue are associated with changes in circulating leptin and BDNF after weight-loss. PURPOSE: To identify changes in adiposity and circulating leptin and …

High Fat Diet Induced Obesity Impairs Skeletal Muscle Glycogen And Lipid Preservation After Adiponectin Incubation, Cesar Meza, Cynthia Montenegro, Catalina De La Peña, Lannie O'Keefe, Shaan Naughton, Anna Simcocks, Deanne Hryciw, Michael Mathai, Andrew Mcainch, Sudip Bajpeyi

International Journal of Exercise Science: Conference Proceedings

High fat diets have been attributed as critical factors contributing to obesity and type 2 diabetes, characterized by increased lipid accumulation, impaired glucose uptake, and defects in glycogen storage in skeletal muscle. Adiponectin, an adipokine, has been shown to have antidiabetic effects by improving fat oxidation and glucose uptake. PURPOSE: To investigate the effects of adiponectin incubation, in high fat diet induced obese rats, on measures of skeletal muscle substrate metabolism including glycogen, glucose transporter 4 (GLUT4), lipid, and mitochondrial contents. METHODS: Male Sprague Dawley rats were fed a Western-style (21% fat by weight; 41% total energy) high …

Metaphors That Communicate Weight-Based Stigma In Political News: A Case Study Of New Jersey Governor Chris Christie, J. Anderson, Y. Zhu, J. Zhuang, J.C. Nelson, M.J. Bresnahan, X. Yan

Communication Studies Publications

News media use metaphors to describe politics (Landau & Keefer, 2014) and obesity (Barry,Brescoll, Brownell, & Schlesinger, 2009). Weight-based stigma is prevalent in U.S. news media (Heuer,McClure, & Puhl, 2011). Media coverage of politicians’ body size may contain metaphors that stigmatizeweight. Metaphors reflect and shape how people think about important issues like politics or obesity(Landau, Sullivan, & Greenberg, 2009; Landau, Meier, & Keefer, 2010; Landau & Keefer, 2014).
Objective – This study uses stigma communication theory (Smith, 2007) to examine stigmatizing metaphors used in media coverage of a United States politician, and candidate for the 2016 Republican presidential nomination, New …

Gestational Diabetes Mellitus And The Predisposing Factors, Syeda Sadia Fatima, Rehana Rehman, Faiza Alam, Sarosh Madhani, Bushra Chaudhry, Taseer Ahmed Khan

Department of Biological & Biomedical Sciences

Objective: To evaluate the occurrence of gestational diabetes mellitus and its association with demographic and anthropometric variables in pregnant women.
Methods: This cross-sectional study was conducted at the Aga Khan University Hospital, Abbasi Shaheed Hospital and Memon Hospital in Karachi, from February 2014 to December 2015, and comprised pregnant women who were screened by 75-g 2-hour oral glucose tolerance test, (24-28 weeks of gestation) and classified as per the criteria of the International Association of Diabetes and Pregnancy Study Group. Weight, body mass index and serum glycated haemoglobin levels were measured. Women with pre-gestational diabetes were excluded. SPSS 21 was …

Obesity: Current And Potential Pharmacotherapeutics And Targets, Vidya Narayanaswami, Linda P. Dwoskin

Pharmaceutical Sciences Faculty Publications

Obesity is a global epidemic that contributes to a number of health complications including cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders. Pharmacotherapeutic strategies to treat obesity are urgently needed. Research over the past two decades has increased substantially our knowledge of central and peripheral mechanisms underlying homeostatic energy balance. Homeostatic mechanisms involve multiple components including neuronal circuits, some originating in hypothalamus and brain stem, as well as peripherally-derived satiety, hunger and adiposity signals that modulate neural activity and regulate eating behavior. Dysregulation of one or more of these homeostatic components results in obesity. Coincident with obesity, reward mechanisms …

Are Soy-Based Proteins, Meals, And Diets An Effective Treatment In Reducing Waist Circumference In Overweight And Obese Adults Ages 20-75 Years?, Lisa Lin

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this evidence based medicine review is to determine whether or not soy-based proteins, meals, and diets are effective treatments in reducing waist circumference in overweight and obese adults ages 20-75 years.

Study design: Review of three published, randomized controlled trials (RCTs) published in 2003, 2007, and 2011. All English language.

Data Source: The three randomized controlled trials that used in this review were found using PubMed.

Outcomes measured: The outcomes measured were improvement of patient’s overweight and obesity status and their overall quality of life through the indication of reduced waist circumference. …

Childhood And Adolescent Obesity: Primary Health Care Physicians’ Perspectives From Riyadh, Saudi Arabia, Faiza Nasser Alotaibi, Majeedah Alotaibi, Shiakhah Alanazi, Hanan Al-Gethami, Deemah Alateeq, Rowaydah Mishiddi, Amna Rehana Siddiqui

Community Health Sciences

BACKGROUND & OBJECTIVES:

Primary health care (PHC) physicians are foremost to confront childhood and adolescent obesity. Our objective was to evaluate PHC Physicians perspectives for managing overweight/obesity in children and adolescents.

METHODS:

PHC services from eight public hospitals in Riyadh participated. A self-administered tool maintaining anonymity evaluated facilitators and barriers for managing overweight/obese children and adolescent patients. Physicians who 'always' recommended weight management for an overweight / obese patient during past year, by involving patient, parents, and others were classified as having positive and appropriate practice.

RESULTS:

Of the 58 respondents, 51.7% had appropriate practices. Lack of patient motivation (82.2%), …

Do Healthcare Professionals With High Weight Biases Provide Different Quality Of Care To Obese Compared To Normal Weight Patients?, Justine Leigh Seymour

Theses and Dissertations

Though weight bias has been acknowledged in the health field, it is less understood if and how weight bias affects quality of care. The purpose of this study was to determine if weight bias exhibited by healthcare professionals (HCPs) impacts quality of healthcare provided to obese individuals. HCPs (n=220; 88% female, 87% nurses) in the Midwest region of the United States were recruited to complete an online survey. Participants completed the Attitude Towards Obese Persons scale (ATOP) to assess weight bias and responded to hypothetical patient scenarios to evaluate quality of care. A median split was calculated for ATOP scores …

Association Of Body Mass Index With Dna Methylation And Gene Expression In Blood Cells And Relations To Cardiometabolic Disease: A Mendelian Randomization Approach, Michael M. Mendelson, Riccardo E. Marioni, Roby Joehanes, Chunyu Liu, Åsa K. Hedman, Stella Aslibekyan, Ellen W. Demerath, Weihua Guan, Degui Zhi, Chen Yao, Tianxiao Huan, Christine Willinger, Brian Chen, Paul Courchesne, Michael Multhaup, Marguerite R. Irvin, Ariella Cohain, Eric E. Schadt, Megan L. Grove, Jan Bressler, Kari North, Johan Sundström, Stefan Gustafsson, Sonia Shah, Allan F. Mcrae, Sarah E. Harris, Jude Gibson, Paul Redmond, Janie Corley, Lee Murphy, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Background

The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain.

Methods and Findings

We conducted an association study of body mass index (BMI) and differential methylation for over 400,000 CpGs assayed by microarray in whole-blood-derived DNA from 3,743 participants in the Framingham Heart Study and the Lothian Birth Cohorts, with independent replication in three external cohorts of 4,055 participants. We examined variations in whole blood gene expression and conducted Mendelian randomization analyses to investigate the functional and clinical relevance of the findings. We identified novel and previously reported BMI-related differential methylation at 83 CpGs …

The Role Of Occupational Therapy In Community-Based Programming: Addressing Childhood Health Promotion, Julie D. Kugel, Heather Javherian-Dysinger, Liane Hewitt

The Open Journal of Occupational Therapy

Background: Obesity and poor health habits impact youth’s health and occupational participation. Occupational therapy’s role in preventing and treating obesity continues to emerge in the research literature. This article explores the impact of a community-based program emphasizing health and wellness for female youth.

Methods: Five girls 11 to 13 years of age participated in the healthy occupations program. Before and after the program, the participants engaged in an individual semi-structured interview and completed the Canadian Occupational Performance Measure and the CATCH Kids Club Questionnaire. The youth participated in a focus group midprogram.

Results: The participants were receptive …

Examining Risk Perceptions And Efficacy For Healthy Weight Management Among Appalachian College-Aged Students: A Test And Extension Of The Risk-Perception-Attitude Framework, Victoria Ann Ledford

Theses, Dissertations and Capstones

Obesity disproportionately affects Appalachia and poses a great risk to young adults who already enact poor health behaviors. Research indicates perceptions of risk and efficacy beliefs related to obesity-preventative behaviors are motivating for positive health-related behavioral change. Moreover, literature reveals that social and emotional risks of obesity may be just as motivating as physical risks. The Risk Perception Attitude (RPA) framework posits that efficacy moderates the effect of perceived risk on associated behavioral outcomes. However, neither the RPA nor other literature addresses the role of stigma in this relationship, though obesity stigma has been linked to a variety of negative …

Kuwait : Obesity, Sabrina Difiori

Global Public Health

The country of Kuwait is known for their extremely high prevalence of obesity. It is a major public health issue for people of both genders. For men, the prevalence for obesity is 36 percent and 48 percent for women. A type of intervention that is often used to fix this problem is stomach stapling: the process of making the stomach smaller to reduce the amount of food intake. If children can start becoming more educated about this issue early on in their lifetime, the prevalence of obesity might not be so high in years to come.

Spain : Childhood Obesity, Emily Haygood

Global Public Health

Throughout the world, obesity is increasing as a public health issue. Specifically, in Spain, which is on the rise for childhood obesity. It is reported that around 1/3 of children in Spain have an excess of weight. Part of this high rate of obesity can be attributed to the high income status. This exposes the population to activities and habits that may lead to poor lifestyle choices. For example, the access to television can decrease activity in children as well as access to fast food can allow for poor nutritional habits.

A System-Level Approach To Overweight And Obesity In The Veterans Health Administration, Susan D. Raffa, Matthew L. Maciejewski, Lindsey E. Zimmerman, Laura J. Damschroder, Paul A. Estabrooks, Ronald Ackermann, Adam G. Tsai, Trina Histon, Michael G. Goldstein

United States Department of Veterans Affairs: Publications

Healthcare systems are challenged by steady increases in the number of patients who are overweight and obese. Large-scale, evidence-based behavioral approaches for addressing overweight and obesity have been successfully implemented in systems such as the Veterans Health Administration (VHA). These population-based interventions target reduction in risk for obesity-associated conditions through lifestyle change and weight loss, and are associated with modest weight loss. Despite the fact that VHA has increased the overall reach of these behavioral interventions, the number of high-risk overweight and obese patients continues to rise. Recommendations for weight loss medications and bariatric surgery are included in clinical practice …

The School Food Environment And Its Association With Dietary Intake Among Rural Adolescents, Hannah F. Hickey

Theses and Dissertations--Nutrition and Food Systems

The school food environment has the ability to increase the consumption of fruit and vegetables in rural adolescents. This study used a survey to allow adolescents in seven rural counties to self-report their fruit and vegetable intake as well as utilizing the USDA Mathematica tool and the School Nutrition and Meal Cost Study audits to evaluate what food and beverage products were actually available to adolescents. By using these two measures, associations between fruit and vegetable intake and availability of healthy and unhealthy foods were determined. The availability of healthy snacks and beverages was found to be associated with sugar-sweetened …

Remote Lifestyle Counseling Influences Cardiovascular Health Outcomes In Youth With Overweight Or Obesity And Congenital Heart Disease, Luis Altamirano-Diaz, Meghan Rombeek, Stefanie De Jesus, Eva Welisch, Harry Prapavessis, Adam A Dempsey, Douglas Fraser, Michael R Miller, Kambiz Norozi

Paediatrics Publications

Background: Children with overweight/obesity and congenital heart disease (CHD) are at increased cardiovascular risk. A lifestyle intervention may help reduce these risks. We sought to determine the feasibility of a smartphone-based lifestyle intervention to improve cardiovascular health outcomes in children with overweight/obesity and CHD.

Methods: We examined the effect of bi-weekly nutrition and fitness counseling delivered

Results: Statistically significant decreases in waist circumference (WC), body mass index

Conclusion: The observed changes in anthropometry were positive with significant improvement to some cardiovascular and metabolic risk indicators. However, this was only observed in the operated group suggesting that other factors, such as …

A System-Level Approach To Overweight And Obesity In The Veterans Health Administration, Susan D. Raffa, Matthew L. Maciejewski, Lindsey E. Zimmerman, Larua J. Damschroder, Paul A. Estabrooks, Ronald T. Ackermann, Adam G. Tsai, Trina Histon, Michael G. Goldstein

United States Department of Veterans Affairs: Publications

Healthcare systems are challenged by steady increases in the number of patients who are overweight and obese. Large-scale, evidence-based behavioral approaches for addressing overweight and obesity have been successfully implemented in systems such as the Veterans Health Administration (VHA). These population-based interventions target reduction in risk for obesity-associated conditions through lifestyle change and weight loss, and are associated with modest weight loss. Despite the fact that VHA has increased the overall reach of these behavioral interventions, the number of high-risk overweight and obese patients continues to rise. Recommendations for weight loss medications and bariatric surgery are included in clinical practice …

Biosociocultural Factors And Motivation To Lose Weight Among Obese African American Women, Odette Marie Russell

Walden Dissertations and Doctoral Studies

Obesity is a pandemic that has a substantial impact among African American women. Biological, social, and cultural acceptance of obesity, collectively referred to as biosociocultural factors, represents an obstacle to efforts to address this health risk among this group. The purpose of this study was to develop a better understanding of the relationship between biosociocultural factors and motivation to lose weight. Self-determination theory, objectification theory, and social learning theory formed the study's theoretical framework. The key research question concerned the extent to which the investigated constructs (BMI, internalized body image, and social networks) helped to explain motivation for weight loss …