Digital Commons Network^™

Evaluation Of Serum Vitamin D And Ferritin Level And Their Correlation With Insulin Resistance And Adiposity In Women With Polycystic Ovarian Syndrome: A Hospital-Based Study In Maharashtra, India, Sunita Machindra Aghade

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Polycystic ovarian syndrome (PCOS) is the utmost prevailing, complex endocrinopathy of reproductive-aged women and one of the fundamental reasons for female infertility. It has been acclaimed as a metabolic syndrome variant in women and comprises a crucial segment of the female population at risk of cardiovascular diseases and type 2 diabetes mellitus. Vitamin D deficiency is connected with deleterious metabolic outcomes in PCOS and may be responsible for exacerbating PCOS symptoms. This hormonal deficiency is linked with insulin resistance (IR), adiposity, impaired glucose and lipid metabolism, and systemic pro-inflammatory milieu in PCOS women. Ferritin, a regulator of iron homeostasis, …

Cazyme Gene Cluster Diversity In Human Gut Microbiome, Yi Xing

Department of Food Science and Technology: Dissertations, Theses, and Student Research

In gut microbiome research, carbohydrate-active enzyme gene clusters (CGCs) have emerged as key functional units for understanding microbial glycan degradation. Unlike taxonomic or broad pathway annotations, CGCs offer gene-cluster-level resolution and capture substrate-specific microbial functions. However, their diversity and distribution in relation to host metabolic phenotypes, such as obesity, remain poorly characterized. This study tests the hypothesis that the composition and abundance of fiber-targeting CGCs vary between obese and healthy human gut microbiomes, reflecting distinct microbial carbohydrate utilization strategies. To examine this, we constructed a high-quality reference CGC dataset comprising 94,019 clusters from the Unified Human Gastrointestinal Genome and profiled …

Chronic Illness Education 2025: Building Healthy Habits: Preventative Strategies For Childhood Obesity, Alissa Ward, Cameron Craig, Chloe Sutlick, Gabrielle Henry, Isabelle Adams, Jerimiah Gumma, Omer Abdullah, Sami Zaidi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Persistent Obesity In A College Student: A Case For Investigating Endocrine Disruptors In Diet, Jake Mcgue, Jolyna Chiangong, Katarina Woldt, Mary-Ann Essak, Muiz Muqri, Nikhil Patel, Redi Gishto

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Exercise Initiatives To Improve Child Obesity, Alice Werynski, Ashley Simbafo, Diana Kernen, Koa Williams, Linda Beqaj, Noah Krepostman, Trevor Buck

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Empowering Families With Resources To Combat Childhood Obesity, Abisola Fasakin, Alqasim Elnaggar, David Abdelnour, Mujeebah Kamal-Muili, Prit Patel, Ryan Palazzolo, Sydney Huston

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: A Highly Misunderstood, Multifactorial Disease, Alexa Maruszewski, Ali Eidy, Chelsea Kumi, Hailey Hartmann, Jacob Pawlowski, Kinan Suliman, Laura Garcia, William Davie

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: School-Centered Interventions To Address Childhood Obesity, Aaron Yang, Amanda York, James Mcknight, Madison Jordan, Myron Shaba, Riley Marchin, Rita Pisegna, Constantine Tangalos

Patient Education Projects

No abstract provided.

Functional Regulation Of Macrophages By Ces1d-Mediated Lipid Signaling In Immunometabolism, Long J Shao, Fathima Elizondo, Feng Gao, Rabie Habib, Xin Li, Katherine Pham, Jazmin Ysaguirre, Maryam Elizondo, Shirindokht Shirazi, Kristin L Eckel-Mahan, Sean Hartig, Huaizhu Wu, Kai Sun

Faculty, Staff and Student Publications

Objective: Macrophage accumulation in metabolically active tissues during obesity is common in both animals and humans, but the lipid signaling mechanisms that trigger macrophage inflammation remain unclear. This study investigates the role of Ces1d, an unconventional lipase, in regulating macrophage inflammation under nutritional stress.

Methods: A myeloid-specific Ces1d knockout (LysM-Cre-Ces1d floxed/floxed, KO) mouse model was used for the studies. For in vitro tests, bone marrow-derived macrophages (BMDMs) from control (Ces1d floxed/floxed, WT) and KO mice were assessed for migration, polarization, and activation. For in vivo experiments, WT and KO mice were induced to obesity via a high-fat diet (HFD) and …

Metabolic Clearance Rate Of Insulin Across The Glucose Tolerance Spectrum By Race And Ethnicity In Youth With Obesity, Wonhee Cho, Fida Bacha, Hala Tfayli, Sojung Lee, Sara F Michaliszyn, Joon Young Kim, Silva Arslanian

Children’s Nutrition Research Center Staff Publications

Objective: Despite β-cell failure in youth with dysglycemia (i.e., impaired glucose tolerance [IGT] and type 2 diabetes), fasting insulin (FI) concentrations are elevated. Herein, we examined the following: 1) metabolic clearance rate of insulin (MCRI) in youth with obesity and normal glucose tolerance (NGT) versus those with IGT versus those with type 2 diabetes; 2) racial and ethnic differences in insulin dynamics; and 3) metabolic/adiposity correlates of MCRI.

Methods: A total of 206 youth underwent assessment of fasting glucose, FI, MCRI and peripheral insulin sensitivity (PIS), first-phase insulin secretion, disposition index, body composition, and abdominal adiposity.

Results: In type 2 …

Clinical Outcomes After Hospitalization For Acute Coronary Syndrome In Patients Treated With Semaglutide Versus Bariatric Surgery: A Retrospective Multicenter Analysis, Nameer Ascandar, Charles Boadu, Gauthier Stepman, George Skaf, Olugbenga Oyesanmi, Sabry Omar, Rias Ali, Michael Schandorf-Lartey

HCA Healthcare Journal of Medicine

Background

Obesity is a chronic medical condition with a rising prevalence in the United States. A wide range of morbidity and mortality is associated with obesity, with coronary artery disease being among the most common. Ischemic heart disease continues to be the primary cause of death in the United States. Taken together, interventions to minimize the detrimental effects of obesity on patients at risk of heart disease will not only benefit the patient, but the health care system as well.

Methods

In this retrospective study, we used the HCA Healthcare enterprise data warehouse to identify all adult patients who were …

"The Growing Burden: Overweight And Obesity Prevalence And Risk Factors Among Medical College Students In Mysuru: A Cross-Sectional Study", Akansha ., Nayanabai Shabadi, Anchu R Nath, Ravipati Manogna

Digital Journal of Clinical Medicine

ABSTRACT:

Background:

The transition from adolescence to adulthood is often accompanied by significant lifestyle changes, including changes in dietary habits, physical activity levels, and stress, which can contribute to unhealthy weight gain. In India, the prevalence of overweight and obesity among youth has shown an upward trend, raising concerns about early onset of non-communicable diseases. This study aims to assess the prevalence of overweight and obesity among degree college students in Mysuru and to identify the associated socio-demographic and lifestyle factors contributing to these conditions.

Methodology:

A cross-sectional study was conducted over three months, from January to March 2025, among …

Impact Of Lifestyle Factors On Breast Cancer Risk And Outcomes: A Scoping Review, Nada Alhazmi

Journal of King Abdulaziz University: Medical Sciences

Aim: This scoping review summarizes evidence on the impact of environmental factors on breast cancer risks and outcomes.

Methodology: A systematic search was performed on PubMed, CINAHL, and ScienceDirect to identify peer-reviewed, English-only sources published between 2020 and 2025 on the impact of lifestyle factors on breast cancer risk and outcomes.

Results: A total of 15 studies (three cohort studies, two cross-sectional studies, five systematic reviews, four narrative reviews, and one case-controlled study) met the inclusion criteria. Evidence from the sources identified physical inactivity, unhealthy diet, obesity, alcoholism, tobacco smoking, menopause, and delayed first-first as lifestyle factors that impact breast …

Obesity And Smoking Status: Relationships With Specific Pulmonary Functions In University Of Babylon College Of Pharmacy Students, Safa W. Aziz

Muthanna Medical Journal

Adult pulmonary function impairment is associated with both smoking and obesity, albeit the consequences vary from person to person. This study aims to evaluate the relationship between smoking and obesity and their relationship to specific pulmonary functions in a selected group of the population (University of Babylon College of Pharmacy students, Iraq). Materials and Methods: The observational study was carried out on 90 male students at the college pharmacy in the University of Babylon, Iraq. Students enrolled in this study were aged between 19-23 years. The control group (30 males) from general students in the college pharmacy without smoking, …

Determinants Of Overweight And Obesity Among Adolescent Students In North Karnataka, Mahaling Mallikarjun Hulagbali, Sangeeta N. Kharde

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Globally, childhood and adolescent obesity prevalence has reached alarming levels with grave public health consequences. It is believed that a sedentary lifestyle and the consumption of calorie-dense and low-nutritional-value foods are two of the most significant etiological factors contributing to the rising prevalence of childhood and adolescent obesity in developing countries.

OBJECTIVE:

The main objective was to study the contributing factors (determinants) of obesity among adolescent students.

MATERIALS AND METHODS:

A cross-sectional study was conducted from January 2019 to October 2019 among 1050 schoolchildren from different schools in Belagavi. The results used for comparison were based on descriptive statistics, …

Obesity And Heart Rate Variability A Cross-Sectional Study In Obese Young Adults, B. A. Soumya, Renu Lohitashwa, Vidya M. Nadiger

Indian Journal of Health Sciences and Biomedical Research KLEU

CONTEXT:

Obesity is one of the important causative factors for multiple co-morbid conditions that can lead to metabolic and cardiac disorders. Many research studies indicate the association of obesity and sudden cardiac deaths.

AIMS:

This study was aimed to evaluate the cardiac autonomic nervous system activity, given by the changes in heart rate variability (HRV) in healthy obese young adults.

SETTINGS AND DESIGN:

This cross-sectional study included thirty obese young adult males of 18–25 years and 30 age-matched healthy adult males. Power spectral analysis of HRV was used to determine the autonomic imbalance.

SUBJECTS AND METHODS:

HRV was performed using …

Obesity Among The Urban Poor Evidence From A Community-Based Study Among Adults Residing In An Underprivileged Area Of Bengaluru City, India, Avita Rose Johnson, Sakthi Arasu, Mitchell Singstock, Nancy Angeline

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND AND OBJECTIVE:

Obesity is increasing among the urban poor and is a major risk factor for diabetes, cardiovascular disease, and cancer. The objective of this study is to assess the prevalence and determinants of obesity among adults over the age of 30 years in an underprivileged community of Bengaluru city.

MATERIALS AND METHODS:

A cross-sectional study was conducted in an underprivileged area of Southern Bangalore. Sociodemographic details, diet, and lifestyle risk factors were assessed by a pretested questionnaire. Anthropometric measurements of height, weight, and waist circumference were recorded and World Health Organization Asian cutoffs for body mass index (BMI) …

Excessive Gestational Weight Retention And Weight Gain In Postpartum Perception Of Women, Thilagavathy Ganapathy

Indian Journal of Health Sciences and Biomedical Research KLEU

CONTEXT:

Childbearing women are the second victims for significant gestational weight retention and weight gain during reproductive years. There may be unique reasons to weight management in this period.

AIM:

To explore what women perceive as reasons for their excessive gestational weight retention and weight gain in the postpartum period.

METHODS:

By purposive sampling,

n

= 200 low-risk postnatal women less than a year of postpartum were recruited and their perceived reasons for excessive gestational weight retention and weight gain in the postpartum period were assessed.

RESULTS:

Participants perceived lowered physical activity, sedentary lifestyle behavior, lack of knowledge, misconceptions that …

Binge Eating Disorder: A Clinical Review, Michell Mcdiffett Mshs, Pa-C

Lynchburg Journal of Medical Science

Binge eating disorder (BED) is the most common eating disorder (ED) in the United States (U.S.) and is characterized by recurrent episodes of eating a larger than normal amount of food in a discrete period of time and includes a sense of loss of control over food intake. BED is often comorbid with serious somatic and psychiatric disorders and is associated with reduced quality of life and excess mortality. Some consider BED a public health concern due to frequent co-occurrence with obesity and worse outcomes in those populations. The diagnosis is often delayed due to shame and underreporting of symptoms …

Obesity And Its Effect On Work Performance, Erin Lajoie

Lynchburg Journal of Medical Science

This research aims to examine how obesity affects work productivity and performance and how companies can support their employees diagnosed with obesity. Obesity is a growing global health concern that has significant implications for decreased workplace productivity and performance. Obesity is considered a chronic complex disease often associated with hypertension (HTN), type-II diabetes mellitus (T2DM), and heart disease that can lead to overall increases in healthcare costs for employers through increased absenteeism, presenteeism, and decreased efficiency. A systemic literature search was completed using PubMed, Cochrane Library, and Google Scholar, identifying multiple journal articles about obesity and productivity in the workplace …

Developing A Healthy Lifestyle Counseling Program In The Medical Home For Pediatric Patients With Obesity: A Pilot Program, Charlotte Helvie, Carrie Gordon, Audra Buschagen, Leah Marie Seften, Tara Palnitkar, Laura J. Faherty

Journal of Maine Medical Center

Problem: Lifestyle changes can significantly improve health outcomes for children with obesity and related chronic medical conditions. Families with limited knowledge about effective ways to improve health with lifestyle changes may benefit from frequent interactions with their health care team. This team can provide additional information and support needed to make and sustain lifestyle changes. Though potentially effective, there are often barriers to this care for both providers (limited time and availability of trained axillary staff) and families (missing school and work for frequent appointments).

Approach: A new lifestyle changes program led by nurses was piloted at a primary care …

Investigation Of The Relationship Between Triglyceride Glucose Index And Metabolic And Hematological Parameters In Obese Individuals, Özge Baş Aksu, Feri̇de Özkara, Rifat Emral, Volkan Genç, Demet Çorapçioğlu, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: This research examined the association between the triglyceride-glucose (TyG) index and metabolic, hepatic, and hematologic variables in a population of severely obese subjects, with a focus on the assessment of glycemic control.

Materials and methods: This retrospective study included 315 adult patients with a body mass index (BMI) ≥ 35 kg/m² who were evaluated for bariatric surgery. Participants were grouped according to HbA1c levels: those with HbA1c ≥ 6.5% and those with HbA1c < 6.5%. TyG, atherogenic index of plasma (AIP), fibrosis-4 (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI), and hematological inflammation markers were assessed and compared between groups. To investigate associations, correlation and regression analyses were conducted.

Results: Individuals with HbA1c ≥ 6.5% had significantly higher TyG, AIP, APRI, and FIB-4 values than those with lower HbA1c. The TyG index showed a strong …

Anti-Obesity Properties Of Binahong (Anredera Cordifolia) Extract On Hepatic Steatosis In Wistar Rats Model, Rusdiana Rusdiana, Tri Widyawati, Dina Keumala Sari, Sry Suryani Widjaja, Dwi Rita Anggraini, Maya Savira, Rusmalawaty Rusmalawaty

Baghdad Science Journal

Obesity, characterized by the accumulation of adipocytes, is associated with complications such as fatty liver and non-alcoholic steatosis, which can be fatal. This research investigates the properties use of Anredera cordifolia ethanol extract in reducing steatosis through microscopic analysis of the non-alcoholic fatty liver disease activity scores (NAS) and immunohistochemical examination (IRS) of PPARγ expression in hepatic cells and abdominal fat tissue in obese Wistar rats .Significant differences were observed in overall steatosis scores among groups (p < 0.005), with the control group (K1) exhibiting markedly higher scores compared to all treatment groups (P50, P100, P150; P < 0.005). Additionally, significant differences in NAS scores were found between the K1 and K2 groups (P < 0.05), as well as among the K0 and K1 groups (P < 0.05). A significant difference in PPARγ IRS was noted between K0 and K2 groups and all treatment groups (P50, P100, P150; P < 0.05). Similarly, a significant difference was observed among the K2 group and all treatment groups (P …