Digital Commons Network^™

Type 2 Diabetes Subgroups, Risk For Complications, And Differential Effects Due To An Intensive Lifestyle Intervention, Michael P Bancks, Haiying Chen, Ashok Balasubramanyam, Alain G Bertoni, Mark A Espeland, Steven E Kahn, Scott Pilla, Elizabeth Vaughan, Lynne E Wagenknecht

Faculty, Staff and Students Publications

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OBJECTIVE: We reevaluated the Action for Health in Diabetes (Look AHEAD) intervention, incorporating diabetes subgroups, to identify whether intensive lifestyle intervention (ILI) is associated with differential risk for cardiovascular disease (CVD) by diabetes subgroup.

RESEARCH DESIGN AND METHODS: In the Look AHEAD trial, 5,145 participants, aged 45-76 years, with type 2 diabetes (T2D) and overweight or obesity were randomly assigned to 10 years of ILI or a control condition of diabetes support and education. The ILI focused on weight loss through decreased caloric intake and increased physical activity. To characterize diabetes subgroups, we applied k-means clustering to data on age …

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Thinking About Availability And Accessibility, Di Fang

Diet, Food, Exercise, and Nutrition (D-FEND)

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Food environments are described, including food deserts and food access.

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Soda, Water, And Convenience: An Evaluation Of The Mexican Soda Tax, Benjamin Hager

Honors Theses

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This thesis seeks to evaluate the Mexican soda tax of 2014 by exploring the reasons for the tax and the underlying factors that the tax seems to ignore. This soda tax, in particular, was implemented to address obesity by curbing the consumption of sugary soft drinks due to the large quantities consumed by the Mexican populous. However, as this thesis shows there are some potential pitfalls in this type of obesity prevention policy. By exploring potable water data from the World Bank, the rural and urban noncommunicable disease rates of two Mexican states, and the penetration of levels of the …

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Sex Differences In Weight Perception And Weight Gain Among Black College Students In The Usa, Jounghee Lee, Jaesin Sa, Jean-Philippe Chaput, James Heimdal, Beatrice Nelson, Beom-Young Cho, Elizabeth Kwon

Human Performance and Sport Sciences faculty Research

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Objectives

The aims of this study were to examine the prevalence of overweight/obesity and to explore sex differences in body weight perceptions and correlates of weight gain among Black students at 2 historically Black colleges and universities (HBCUs) in the USA.

Methods

Participants completed a paper-based survey, and their height and weight were measured (67% completion rate).

Results

The overweight and obesity rates were 33.8% and 26.9%, respectively. More females than males accurately assessed their weight (p<0.05). Body weight underestimation was associated with male sex, excellent/very good perceived overall health, and not being informed by a doctor of having overweight or obesity (p<0.01). Higher odds of ≥5% weight gain were related to female sex, living on campus, and not being informed by a doctor of having overweight or obesity (p<0.05).

Conclusion

Given the high overweight and obesity rates among Black students, HBCUs in the USA should develop intervention strategies for …

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Overcoming Obesity: Provider Reminders And Education In Pediatrics, Michelle Warren

Evidence-Based Practice Project Reports

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The prevalence of pediatric overweight and obesity is rising globally (Di Cesare et al., 2019) and results in lifelong chronic health problems and an estimated annual healthcare cost of $14.1 billion (Trasande & Chatterjee, 2009). The purpose of this evidence-based practice project was to address overweight and obesity in patients between the ages of five and 12 years through the provision of provider reminders, education, and guidelines. Primary outcomes included frequency of diagnosis, frequency of patient referrals, return to see times, and frequency of patient nutrition and activity education while secondary outcomes included patient weight, body mass index (BMI), and …

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Doctoral Capstone Experience- Exercise, The Obesity Epidemic, And The Pediatric Population, Jessie L. Fontenault

Department of Occupational Therapy Entry-Level Capstone Projects

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No abstract provided.

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Final Culminating Project: Program Development, Erin Helms

Department of Occupational Therapy Entry-Level Capstone Projects

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This 16-week capstone project was completed at Parker Place, a children’s health, and wellness center, with a focus on program development and advocacy with additional work related to leadership and administration. The overall goal of the capstone project was to determine the benefit of using an occupation-based approach to enhance health outcomes for the patients at Parker Place. The capstone student provided education about the role of occupational therapy in a non-traditional setting, created a program to help patients acquire sustainable healthy habits, developed a workshop for families struggling to maintain a healthy lifestyle, and provided resources about picky eating …

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Dietary Strawberries Improve Cardiometabolic Risks In Adults With Obesity And Elevated Serum Ldl Cholesterol In A Randomized Controlled Crossover Trial, Arpita Basu, Kenneth Izuora, Nancy M. Betts, Jefferson W. Kinney, Arnold M. Salazar, Jeffrey L. Ebersole, R. Hal Scofield

Kinesiology and Nutrition Sciences Faculty Research

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Background and aims: Dietary berries, such as strawberries, are rich in bioactive compounds and have been shown to lower cardiometabolic risk. We examined the effects of two dietary achievable doses of strawberries on glycemic control and lipid profiles in obese adults with elevated serum LDL cholesterol (LDL-C). Methods: In this 14-week randomized controlled crossover study, participants were assigned to one of the three arms for four weeks separated by a one-week washout period: control powder, one serving (low dose: 13 g strawberry powder/day), or two-and-a-half servings (high dose: 32 g strawberry powder/day). Participants were instructed to follow their usual diet …

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Changes In Body Mass Index Among Antiretroviral Therapy Naïve People Living With Hiv In Southeastern Nigeria, John O. Olawepo, Jennifer R. Pharr, Chad L. Cross, Babayemi O. Olakunde, Chinedu Aniekwe, Mercy Niyang, Raisa Kabir, Ayodotun Olutola

Environmental & Global Health Faculty Research

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The proportion of people living with HIV (PLHIV) who are overweight or obese is rising, leading to a double epidemic of HIV and obesity. The purpose of this retrospective longitudinal study was to examine changes in body mass index (BMI) among PLHIV who were new to antiretroviral therapy (ART) in two states in Southeastern Nigeria. The BMI at baseline and 12 months were compared and the difference in proportions in each BMI category was tested. The association between the BMI at 12 months and the demographic and/or clinical variables was examined using multiway analysis of covariance. The study included 2,146 …

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Pediatric Obesity: Prevention, Assessment And Treatment In Primary Care, Susan Johnson

Theses and Graduate Projects

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People of all ages deserve care for the disease of obesity. Pediatric obesity affects one in three children in the United States, and the number of obese children has tripled since the 1970s (Centers for Disease Control and Prevention (CDC), 2018a). High blood pressure, high cholesterol, type 2 diabetes, and sleep apnea are complications that pediatric patients now face, and these diseases are well known to worsen quality of, and potentially shorten life. This scholarly project addresses the question: How can family nurse practitioners effectively address pediatric obesity in the primary care setting? Interventions early in life, perhaps even pre-conception, …

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The Prevalence Of Hyperpalatable Baby Foods And Exposure During Infancy: A Preliminary Investigation., Kai Ling Kong, Tera L. Fazzino, Kaitlyn M. Rohde, Katherine S. Morris

Manuscripts, Articles, Book Chapters and Other Papers

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Objective: To characterize the prevalence of hyperpalatable foods (HPF) among baby foods in the U.S. and examine the prevalence of HPF exposure and consumption from both baby food and adult food sources among infants aged 9-15 months.

Methods: A U.S. baby food database as well as baby foods from three 24-h dietary recalls of 147 infants were used to identify baby foods as HPF per previous publication. HPF exposure was defined as intake of any HPF during the 3-day measurement period. To determine the extent of HFP consumption, % kilocalorie (kcal) intake from HPF was characterized.

Results: Only 12% of …

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Diabetes And Cancer: Metabolic Association, Therapeutic Challenges, And The Role Of Natural Products, Wamidh H. Talib, Asma Ismail Mahmod, Sara Feras Abuarab, Eliza Hasen, Amer A. Munaim, Shatha Khaled Haif, Amani Marwan Ayyash, Samar Khater, Intisar Hadi Al-Yasari, Lina T. Al Kury

All Works

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Cancer is considered the second leading cause of death worldwide and in 2018 it was responsible for approximately 9.6 million deaths. Globally, about one in six deaths are caused by cancer. A strong correlation was found between diabetes mellitus and carcinogenesis with the most evident correlation was with type 2 diabetes mellitus (T2DM). Research has proven that elevated blood glucose levels take part in cell proliferation and cancer cell progression. However, limited studies were conducted to evaluate the efficiency of conventional therapies in diabetic cancer patients. In this review, the correlation between cancer and diabetes will be discussed and the …

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Investigating The Economic Effects Of Food Affordability, Food Access, And Education On Obesity Rates In Mississippi Counties, Youssef Osman

Honors Theses

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The growing rate of obesity across the United States is a topic of great concern considering both the health and financial costs associated with the disease. Many researchers have sought to determine the major causes of obesity so that policy suggestions can be made to reduce its occurrence. Some of the referenced drivers of obesity include high food costs, poor access to healthy food, and a lack of knowledge regarding nutrition. This thesis seeks to find the effects of county-level food prices, income, food access, and education level on obesity rates in Mississippi counties. The analysis uses cross-sectional data from …

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Physiological Responses To Active Video Games Compared To Treadmill Walking And Tv Watching In Obese Children And Adolescents, Ramzi Majaj, Trent Scott, Ryan Moran, Dana Kimberly, Tamekia Jones, Webb Smith

International Journal of Exercise Science

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International Journal of Exercise Science 14(7): 519-532, 2021. The purpose of this study was to examine the physiological responses to playing different active video games (AVG), as well as document the activity level exerted during AVG in relation to treadmill walking (TM) and watching television (TV). 20 youth (age 11-17 yr) with obesity were recruited from the Healthy Lifestyle Clinic and underwent testing under six randomized conditions: 1) TM, 2) TV, 3) Fitnexx, 4) river rush (RRH), 5) reflex ridge (RFR), and 6) space pop (SP). RRH, RFR, and SP are active video games for the Xbox 360. Fitnexx is …

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High-Fat Feeding Disrupts Daily Eating Behavior Rhythms In Obesity-Prone But Not In Obesity-Resistant Male Inbred Mouse Strains, Tiffany N. Buckley, Oluwabukola Omotola, Luke A. Archer, Cameron R. Rostron, Ellora P. Kamineni, Josie D. Llanora, Jeffrey M. Chalfant, Feitong Lei, Emily Slade, Julie S. Pendergast

Teacher Education and Certification Faculty Research & Creative Works

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Abnormal meal timing, like skipping breakfast and late-night snacking, is associated with obesity in humans. Disruption of daily eating rhythms also contributes to obesity in mice. When fed a high-fat diet, male C57BL/6J mice have disrupted eating behavior rhythms and they become obese. In contrast to obesity-prone C57BL/6J mice, some inbred strains of mice are resistant to high-fat diet-induced obesity. In this study, we sought to determine whether there are distinct effects of high-fat feeding on daily eating behavior rhythms in obesity-prone and obesity-resistant male mice. Male obesity-prone (C57BL/6J and 129X1/SvJ) and obesity-resistant (SWR/J and BALB/cJ) mice were fed low-fat …

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Advertising To Children And The Long-Term Effects Of Obesity On Health Equity, Joirdon Karl Nicholas

Honor’s College Freeman Research Journal

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America spends more money on health than people anywhere else in the world and ranks 11th in the world of developed nations in terms of performance. Americans live shorter less healthier lives and the trends are not improving especially in minority communities. In my research, Americans are focused on the wrong things when they think about health. Health is not defined by seeing a physician or taking medicines. Health should be defined as life circumstances, from the cultures we come from, and the neighborhoods we live in. Advertising to children that leads to obesity has generational impact especially in minority …

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Prevalence Of Liver Cirrhosis And Its Association With Obesity Among Hispanics And Mexican Americans: An Evidence Synthesis, Alexa Perlick, Abaigeal Thompson, Colton Wayne, Angel Rendon, Jose Campo Maldonado

MEDI 9331 Scholarly Activities Clinical Years

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INTRODUCTION

The obesity epidemic is a growing public health concern. In addition to the already known complications and comorbidities associated with obesity, data suggest that obesity is an independent risk factor for the development of liver disease.^1,2 However, there is a paucity of data regarding the clinical correlation of obesity and cirrhosis in a predominantly Hispanic population of South Texas. The aim of this systematic literature review is to investigate the prevalence of cirrhosis stratified by obesity in Hispanic populations.

MATERIALS AND METHODS

PubMed was used to perform a thorough literature search. The terms liver cirrhosis and obesity were …

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Milk-Fat Intake And Differences In Abdominal Adiposity And Bmi: Evidence Based On 13,544 Randomly Selected Adults, Klarissa Rae Wilkinson

Theses and Dissertations

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The primary objective of this study was to evaluate the relationship between milk-fat intake and obesity, particularly abdominal obesity, in 13,544 U.S. adults. A secondary objective was to determine the extent to which the association was influenced by multiple potential confounding variables. This cross-sectional study used data from the 2011–2016 National Health and Nutrition Examination Survey (NHANES). Level of milk-fat content regularly consumed was the exposure variable. Body mass index (BMI) and sagittal abdominal diameter (SAD), a measure of abdominal obesity, were the outcome variables. SAD correlates strongly with visceral fat, when measured by computed tomography, and has been shown …

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Stakeholder Perspectives And Sustainability Of An Integrated Care Model For The Prevention And Management Of Obesity: The Childhood Obesity Research Demonstration (Cord) Project, Rebecca E Lee, Nathan H Parker, Allen M Hallett, Dennis Kao, Maria J Modelska, Hanadi S Rifai, Erica G Soltero, Daniel P O'Connor

Children’s Nutrition Research Center Staff Publications

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Although reliable strategies exist to promote healthy habits that reduce childhood obesity, the sustainability of these strategies remains an ongoing public health challenge. This study aimed to identify factors experienced in a large, multisite project aimed at reducing childhood obesity that might contribute to project sustainability. Hypothesized constructs underpinning sustainability included replicability, continuation of benefits, institutionalization, and community capacity. Key informants (n = 27) completed 60 min, in-depth interviews, which were audio recorded and transcribed. Transcripts were first coded using a combined deductive and inductive approach. Four major themes emerged (with numerous subthemes): developing partnerships, challenges to the sustainability …

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Mobilizing Rural Communities To Create Systemic Changes To Reduce Health Disparities, Denise Everson, Amanda Tedrow, Al Parker Edd

National Youth Advocacy & Resilience Conference

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USG institutions are creating strategies to enhance community capacity in addressing health inequities, "closing the gap" between suggested optimal development models and helping prepare a visioning masterplan in rural communities.

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Cardiovascular Health Risk Of Collegiate Division 1 American-Style Football Athletes, Ashley Ring

Department of Nutrition Student Projects

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Background: Cardiovascular disease (CVD) is considered the leading cause of death around the world, with risk factors including obesity and hypertension. Collegiate American Style Football (ASF) players make up a unique subset of the population that could be at an increased risk of CVD. This cross-sectional study aims to evaluate the presence of cardiovascular risk factors in a Division 1 ASF team.

Methods: The researchers analyzed the body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), and body fat percentage (BF%) of the team as a whole (n=38); and then compared the …

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Heterogeneous Contributions Of Change In Population Distribution Of Body Mass Index To Change In Obesity And Underweight, Ncd Risk Factor Collaboration (Ncd-Risc), Maria Lc Iurilli, Bin Zhou, James E. Bennett, Rodrigo M. Carrillo-Larco, Marisa K. Sophiea, Andrea Rodriguez-Martinez, Honor Bixby, Bethlehem D. Solomon, Zulfiqar Ahmed Bhutta

Woman and Child Health

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From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape …

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Impact Of Pediatric Obesity On Diurnal Blood Pressure Assessment And Cardiovascular Risk Markers, Margaret O. Murphy, Hong Huang, John A. Bauer, Aric Schadler, Majd Makhoul, Jody L. Clasey, Aftab S. Chishti, Stefan G. Kiessling

Pediatrics Faculty Publications

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Background: The prevalence of hypertension is increasing particularly among obese children and adolescents. Obese children and adolescents with hypertension are likely to remain hypertensive as they reach adulthood and hypertension is linked to an increased risk for cardiovascular disease. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) has become one of the most important tools in diagnosing hypertension in children and adolescents and circadian patterns of blood pressure may be important disease-risk predictors.

Methods: A retrospective chart review was conducted in patients aged 6–21 years who underwent 24-h ABPM at Kentucky Children's Hospital (KCH) from August 2012 through June 2017. Exclusion criteria …

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Evaluation Of A Health Education Intervention For Rural Preschool And Kindergarten Children In The Southeastern United States: A Cluster Randomized Trial, Holli H. Seitz, Julie C. Parker, Heather L. Hanna, Ginger C. Hooge

Journal of Human Sciences and Extension

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This research employed a matched-pairs randomized field experiment design to evaluate a classroom-based health education intervention for pre-Kindergarten and Kindergarten children in a rural region of the southeastern United States. Schools were matched on demographic characteristics, then one school from each pair was randomly assigned to the treatment group and one to the delayed treatment group. The intervention included a field trip experience and an integrated curriculum designed to increase knowledge about nutrition, physical activity, and sleep. Staff conducted individual assessments of changes in knowledge with a random sample of children from each classroom (252 children from treatment classrooms; 251 …

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Prescribed Exercise To Reduce Recidivism After Weight Loss-Pilot (Prevail-P): Design, Methods And Rationale, Damon L. Swift, Joshua E. Mcgee, Anna C. Huff, Marie C. Clunan, Nicole R. Gniewek, Taylor T. Brown, Briceida G. Osborne, Colleen Bucher, Charles J. Tanner, Savanna G. Barefoot, Patricia Brophy, Angela Clark, Gabriel S. Dubis, Corby K. Martin, Robbie A. Beyl, Joseph A. Houmard, Robert A. Carels, Walter Pories, Laura E. Matarese

Clinical Research Faculty Publications

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Clinically significant weight loss is associated with health benefits for overweight and obese adults. Participation in adequate amounts of physical activity is critical for weight maintenance. However, the recommended amount of physical activity needed to promote weight maintenance is based primarily on retrospective studies that quantified physical activity levels through questionnaires which tend to overestimate physical activity levels. In addition, the present literature has provided little data on the impact of these physical activity levels on cardiovascular and diabetes risk factors, which may have equal or more clinical importance than weight changes. The Prescribed Exercise to Reduce Recidivism After Weight …

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Deficiency Of Stat1 In Cd11c+ Cells Alters Adipose Tissue Inflammation And Improves Metabolic Dysfunctions In Mice Fed A High-Fat Diet, Antu Antony, Zeqin Lian, Xiaoyuan Dai Perrard, Jerry Perrard, Hua Liu, Aaron R Cox, Pradip Saha, Lothar Hennighausen, Sean M Hartig, Christie M Ballantyne, Huaizhu Wu

Faculty, Staff and Students Publications

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CD11c+ macrophages/dendritic cells (MDCs) are increased and display the classically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammation and insulin resistance. Stat1 is a key transcription factor for MDC polarization into the M1-like phenotype. Here, we examined the role of Stat1 in obesity-induced AT MDC polarization and inflammation and insulin resistance using mice with specific knockout of Stat1 in MDCs (cKO). Stat1 was upregulated and phosphorylated, indicating activation, early and persistently in AT and AT MDCs of wild-type mice fed a high-fat diet (HFD). Compared with littermate controls, cKO mice fed an HFD (16 …

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Impact Of Obesity On Day-Night Differences In Cardiac Metabolism, Sobuj Mia, Ravi Sonkar, Lamario Williams, Mary N Latimer, Isabelle Frayne Robillard, Abhinav Diwan, Stuart J Frank, Christine Des Rosiers, Martin E Young

2020-Current year OA Pubs

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An intrinsic property of the heart is an ability to rapidly and coordinately adjust flux through metabolic pathways in response to physiologic stimuli (termed metabolic flexibility). Cardiac metabolism also fluctuates across the 24-hours day, in association with diurnal sleep-wake and fasting-feeding cycles. Although loss of metabolic flexibility has been proposed to play a causal role in the pathogenesis of cardiac disease, it is currently unknown whether day-night variations in cardiac metabolism are altered during disease states. Here, we tested the hypothesis that diet-induced obesity disrupts cardiac "diurnal metabolic flexibility", which is normalized by time-of-day-restricted feeding. Chronic high fat feeding (20-wk)-induced …

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The Association Between Overnight Fasting And Body Mass Index In Older Adults: The Interaction Between Duration And Timing, Qian Xiao, Cici Bauer, Tracy Layne, Mary Playdon

Faculty, Staff and Student Publications

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BACKGROUND: Circadian rhythms play an important role in the regulation of eating and fasting, and mistimed dietary intakes may be detrimental to metabolic health. Extended overnight fasting has been proposed as a strategy to better align the eating-fasting cycle with the internal circadian clock, and both observational and experimental studies have linked longer overnight fasting with lower body weight. However, it remains unclear if the timing of overnight fasting modifies the relationship between fasting duration and weight outcomes.

METHODS: The current study included 495 men and 499 women age 50-74 years. Dietary intake over 12 months was assessed by 24-h …

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Association Between Height And Hypertension Among Us Adults: Analyses Of National Health And Nutrition Examination Survey 2007-18, Rajat Das Gupta, Maxwell Akonde, Ibrahim Hossain Sajal, Gulam Muhammed Al Kibria

Publications

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Background

Previous studies that investigated association of height with prevalence and control of hypertension found mixed results. This cross-sectional study explored these associations among US adults (≥20 years).

Methods

The National Health and Nutrition Examination Survey (NHANES) 2007–18 data was analyzed. Height was measured in meters and was converted into centimeters (cm) and was further divided into quartiles: Q1 (135.3–159.2 cm), Q2 (159.3–166.2 cm), Q3 (166.3–173.6 cm), Q4 (173.7–204.5 cm). Hypertension definition of the ‘2017 American College of Cardiology/American Heart Association Guideline’ was used. Logistic regression analyses were conducted to find out the association between the dependent variable and the …

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Metabolic Flexibility Across The Spectrum Of Glycemic Regulation In Youth, Fida Bacha, Sara Klinepeter Bartz, Maurice Puyau, Anne Adolph, Susan Sharma

Children’s Nutrition Research Center Staff Publications

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BACKGROUNDMetabolic flexibility (MF) refers to the relative ability to utilize lipid and carbohydrate substrates and to transition between them. It is not clear whether MF is impaired in obese youth and what the determining factors are.METHODSWe investigated the determinants of MF (increased respiratory exchange ratio [ΔRER] under insulin-stimulated conditions) in pubertal youth (n = 104; 15.6 ± 1.8 years) with obesity across the spectrum of glucose tolerance compared with normal weight (NW) controls, including body composition (fat-free mass [FFM], %body fat), visceral adipose fat (VAT) (MRI), glycemia, and insulin sensitivity (IS) [3-hour hyperinsulinemic-euglycemic clamp with measurement of lipolysis ([2H5] glycerol), …

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