Digital Commons Network^™

The Effects Of Tri-O-Tolyl Phosphate (Totp) On The Immune System Of Mice, Craig R. Brinkerhoff

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

TOTP is a prevalent industrial and environmental contaminant which has been shown to be a neurotoxic agent. This study was undertaken to investigate the effects of this compound on the immune system. Several techniques were employed to test the humoral as well as cellular effects. Male Swiss Webster mice were administered by gastric gavage with three doses of TOTP (5, 50, and 500 mg/kg) and one dose TMTP (50 mg/kg) in corn oil once a week for 13 weeks. Control animals were given corn oil alone.

Lymphocyte transformation was determined on cultures of splenic cells obtained from animals sacrificed at …

Population Ecology Of The Beach Mouse, Peromyscus Polionotus Niveiventris, Douglas Dale Extine

Retrospective Theses and Dissertations

No abstract provided.

Swimming As A Determinate To Immigration For Two Small Mammals In Coastal Virginia, Jeffrey Lewis Carter

Biological Sciences Theses & Dissertations

Small mammals were live trapped on the mainland and on an island located in the southeast corner of Virginia. The area was characterized by a mid-Atlantic coastal climate. White-footed mice (Perompsous fsucopus) were trapped on the mainland but not on the island, whereas meadow voles (Microtus psnnsylvimious) inhabited only the island. A series of swimming tests were performed in both the field and in the laboratory on both of these species to determine if swimming abilities could be the factor preventing Pszomysous from colonizing the island.

Both species of small mammals showed good swimming endurance in …

An Ultrastructural Study Of Intramuscular Melanocytes In Pet/Wmr Mice, Charles August Gomer

Master's Theses

An examination of the lateral head of the gastrocnemius of the PET/Wn!.r mouse was made with an electron microscope. Cells of the perimysium and endomysium were described and the relationship of these cells to muscle cells was characterized. The relationship between melanocytes and muscle cells found in this strain was the major focus. Melanocytes were seen to be present in the perimysium and endomysium with the greatest concentration in the endomysium. Melanocytes of the perimysium appeared segregated from the adjacent tissue by fibroblasts,which surround ed the melanocytes with their cytoplasmic processes, a well as by collagen fibers. Melanocytes of the …

The George-Anne, Georgia Southern University

The George-Anne

• Second Front
• Southern People
• Features
• Sports
• Classified

The Daily Rhythm Of Paneth Cells In Mus Musculus , Ann Tackman Dunlop

Graduate Dissertations and Theses

Location and Morphology of Paneth Cells

Paneth cells (Figs. 1 and 15) are conspicuous cells found at the base of the intestinal crypts, throughout the length of the small intestine, in mammals. They were first discovered by Schwalbe (1872) and extensively described by Paneth (1888). These cells contain large (1-3 u) spherical, acidophilic granules. As seen with the light microscope (LM), Paneth cells have basal basophilia (an indication of ribosomes), a basally located, often deeply indented nucleus, a supranuclear Golgi apparatus, and secretory granules in the supranuclear region and apical cytoplasm.

Paneth Cell Ultrastructure

The Paneth cell secretory granules of …

The Effects Of Prolonged Ultraviolet Irradiation On The Pigment System Of Pet/Wmr Mouse Epidermis, Penny Suzanne Nair

Master's Theses

Repeated exposure to ultraviolet radiation brings about an increase in the DOPA-positive melanocyte population of the human. However, there is an age-dependent decline in the melanocyte population regardless of UV irradiation. In the rhesus monkey, a drop in the DOPA-positive epidermal melanocyte population has been observed after prolonged UV irradiation. The population of DOPApositive epidermal melanocytes in PET/Wmr mice reaches a peak during the first post-natal week after which the number of cells declines, fading almost completely within 3 weeks. Their occurrence in adult mice is rare. With UV irradiation (300 nm) the melanocyte population of newborn and adult PET …

The Effects Of Environmental Switchovers Between Enrichment And Impoverishment On Brain And Behavior In Mice, Judith K. Ahroon

Graduate Dissertations and Theses

Rearing rodents or primates in environments that are comparatively enriched or impoverished results in often impressive physiological and anatomical changes after a certain period of exposure. However, the anatomical and biochemical characteristics that respond to environmental experience (Bennett, Diamond, Krech, & Rosenzweig, 1964; Greenough & Volkmar, 1973; Walsh, Budtz-Olsen, Penny, & Cummins, 1969) have been subjected to a more sophisticated level of analysis than have the less consistent changes in behavioral tendencies. The specific nature of environmentally induced modifications in behavioral tendencies must be better understood, if substantive predictions about brain-behavior relationships can be made. Furthermore, the long-term effects of …

The Effects Of Topical Nitrogen Mustard On The Pigment System In Pet/Wmr Mouse Epidermis, Ronald Lee Salisbury

Master's Theses

Miniature melanocytes have been observed scattered among the typical melanocytes in the skin of the PET/Wmr mouse strain, They are weakly DOPA reactive and their cell bodies and nuclei are one quarter the size of those in typical melanocytes, Both populations reach a peak during the first postnatal week and then gradually disappear within the following three weeks. The miniatures appear very early and are among the last cells to disappear. During the first postnatal week, their population remains relatively constant against a radically changing population of typical melanocytes. That they may represent a stage in the development of typical …

Biochemical Parameters Of Hereditary Chondrodysplasia In Mice, Trent D. Stephens

Theses and Dissertations

Cartilage from newborn mice homozygous for chondrodysplasia contains normal quantities of protein and chondroitin sulfate. Mutant fetal cartilage incorporates normal amounts of sulfate, glucose, and glucosamine. Overnight rinsing with water removes about 25% of the incorporated sulfur and existing uronic acid from mutant ribs and about 55% from mutant limbs. Control ribs and limbs are affected very little by such a rinse. The diffusability of chondroitin sulfate (represented by incorporated sulfur and uronic acid) may be due to a lack of covalent bond formation between chondroitin sulfate and collagen.

Generality Of Learning Differences In Mice Genetically Selected For Differences In Brain Weight, Craig Jensen

Graduate Dissertations and Theses

Mice selected for high, medium, and low brain weight were raised in an enriched environment and tested on open field, active avoidance, water maze, operant discrimination, and passive avoidance tasks. Mice from one foundation stock yielded mice with high and low brain weight. The control groups for this selection were composed of one group of medium brain weight mice subjected to stabilizing selection and a heterogeneous group of mice which was not subjected to any selection. The mice in the two control groups were derived from the same foundation stock as the high and low brain weight mice. In addition, …

An Improved Holding Chamber For The Measurement Of Oxygen Consumption In Mice, Kenneth M. Cook, Thomas J. Doody

Proceedings of the Iowa Academy of Science

An apparatus is described which has been useful in classroom demonstrations and for research in metabolic studies of mice. The unique feature of this modification of basic metabolators is a standard taper ground glass joint.

A Simulation Model Of Peromyscus Leucopus In An Area Of The Great Dismal Swamp, James E. Paschal Jr.

Biological Sciences Theses & Dissertations

A computer simulation model was developed to explain the population dynamics of the white-footed mouse (Peromyscus leucopus) in an area of the Great Dismal Swamp. The model was designed to provide an experimental base for future studies. The model indicates relationships between food availability, home range size, competition with Peromyscus nuttali habitat selection and reproduction.

White-footed mice were trapped in the Old Dismal Town site during each season from April, 1972 through March, 1973. The age-sex structure of the population was determined, and was compared with the simulated structure. Although there were significant discrepancies between the comparisons, the …

The Effects Of Ultraviolet Irradiation On The Pigment Cells Of The Pet/Wmr Mouse Epidermis, Vaughan Henry Howard Jr.

Master's Theses

Epidermal melanocytes in mammals are known to occur in a variety of shapes, sizes, and colors. The basic melanocyte morphology is dependent upon genetics, but there are a number of environmental factors that can cause modification.

In the epidermis of PET/\vrnr mice, the population of rnelanocytes reaches a peak and begins to decline during the first post-natal week, and has disappeared within four weeks. Dispersed among the large, highly DOPA-reactive melanocytes are miniature melanocytes. These miniature melanocytes are weakly DOPA-reactive and appear early in the post-natal period. The miniature melanocyte population is relatively constant and these miniature cells are among …

The Induced Differentiation Of Mouse Ectoderm To Epidermis By Growth On Freeze-Thawed Dermis, Albert Joseph Banes

Master's Theses

Previous investigators have grown or maintained adult or embryonic skin in tissue culture and on the chorioallantoic membrane (CAM) of chickens. These studies have revealed two important factors involved in culturing skin: (1) the presence of an inducer which originates in the dermis and affects the phenotype of epithelial cells; and (2) the influence of the physical surface of the substrate on which epidermis is cultured.

The current investigation presents evidence that ectoderm from the limb buds of 10 to 12 day-old mouse embryos can form an epidermis when combined with dermis killed by alternate freezing and thawing, and cultured …

Ddt-Induced Chromosomal Aberrations In Mice, Gregg A. Johnson

Theses and Dissertations

No abstract provided.

Possible Carriers In Mouse Erythrocytes, Joseph Doyle Mcclure

University of the Pacific Theses and Dissertations

Early qualitative erythrocyte permeability studies (Gryns, 1896; Hedin, 1897) revealed the wide range of non-electrolyte permeability rates across a cell membrane composed of lipid molecules. Theoretically, water-soluble non-electrolytes such as glycerol, ethylene glycol and erythritol would penetrate less rapidly than lipid-soluble non-electrolytes. It was thought that the rate of penetration of water-soluble non-electrolytes was inversely proportional to their molecular size and the penetration of lipid-soluble non-electrolytes was directly proportional to their lipid-solubility.

Laboratory Studies Of Two Species Of Jackrabbit Bot Flies, Craig R. Baird

Biology

The life history and host and site specificity of Cuterebra jellisoni Curran and Cuterebra ruficrus Austen were studied under laboratory conditions. Adult flies of each species were induced to mate. C. jellisoni eggs required seven to eight days for incubation, and C. ruficrus required nine to ten days. First instar larvae were successfully introduced into lagomorph hosts via all natural openings. Regardless of the introduction site, however, each species of larva was later found in a specific terminal site. C. jellisoni larvae completed development in jackrabbit hosts in 36 days and were found in subcutaneous cysts on the head. C. …

Refractoriness Of Pet Mouse Integument To The Nerve Growth Factor, Walter Hollified Dorman

Master's Theses

This paper deals with the refractoriness of PET mouse integument to the subcutaneous administration of nerve growth factor. Newborn mice were injected once daily with NGF through ten injections. Gross and histological examination showed that the skin of the experimental animals was completely unresponsive to this agent. No alterations in the hair growth cycle or pattern were observed.

Lasting Biological Effects Of Early Influences, René Dubos

MCV/Q, Medical College of Virginia Quarterly

In conclusion: The environment does more than affect our well-being in the here and now. It molds the young, physically and mentally, and thereby determines almost irreversibly their future and the evolution of society.

Karyotype Analysis Of Peromyscus Maniculatus Bairdii Populations In Northeastern North Dakota, Robert A. Ahokas

Theses and Dissertations

No abstract provided.

A Comparative Study Of The Sulfhydryl Groups In The Gastrocnemius Of The Normal And X-Irradiated Pet Mouse, Robert Edward Shervette

Master's Theses

It has been recognized that hyperpigmentation of the skin is the result of eliminating the. -SH inhibition when treatment is by x-irraidiation. The results of a. study by fieams and Schaeffer indicate : a progressive increase of melanocytes in the skin with an increasing dosage of x-irradiation. However, it was also noted that the effect of x-irradiatin on the gastrocnemius of the PET mouse resulted in a decrease in the number of intramuscular melanocytes. The present study was designed to determine whether the changes in the x-irradiated muscle is related to possible changes in -SH concentration.The technique employed is a …

The Effects Of A Nerve Growth-Promoting Protein On The Integument Of Pet Mice, Craig Bauman Satterlee

Master's Theses

A factor which specifically stimulates the growth of sensory and sympathetic nerve cells has been under investigation for a number of years. This factor, originally isolated in 1951, from mouse sarcomas 37 and 180, was named the "nerve growth factor". Its action was first shown in vivo by inoculating the sarcoma into chick embryos and subsequently in vitro by culturing chick ganglia and mouse sarcoma together. In the years immediately following the initial discovery, much more potent sources of NGF were found in the salivary glands and salivary secretions of a variety of species. These include rattle snake venom, and …

The Distribution Of Three Taxa Of Peromyscus In Central Washington, Gay Harold Engelsen

All Master's Theses

One aspect of the study was to define the present ranges of all types of Peromyscus in the study area; the other to determine the extent of interfertility of the groups.

The Effects Of Single-Dose X-Irradiation On Melanocytes In The Leg Musculature And Skin Of The Pet Mouse, Barry Eckert Schaeffer

Master's Theses

While most investigations have been limited to the study of pigment cells in the epidermis and hair follicles, this work embraces pigmentation of the leg muscles and dermis as well. To this end, PET mice were used which have an abundance of pigment cells in the leg muscles, but which show restriction of integumentary melanocytes to the dermis and hair. This characteristic provided the unique opportunity of comparing isolated systems of pigment cells in their response to identical stimuli of x-rays. Because pigment cells originate in the neural crest early in development and migrate throughout the embryo, all pigment cells …

Newsletter, Volume 05, Number 02, September 1960

Newsletter: A Report to Physicians of Texas Archives

• Fifth Annual Clinical Conference, October 21 and 22
• Research Expansion
• Foreign Vistors
• Assistant Director Appointed
• Fourth Year Book of Cancer
• Staff Appointments
• Sixteen High School Science Students Began Training June 15 at MDAH
• Radiation Protection Lecture
• Pediatric Oncology
• Staff Activities
• Staff Publications
• Grants Announced

The Influence Of Age On The Liver Phospholipid Metabolism Of Mice, John H. Reiter

Theses and Dissertations

No abstract provided.

Some Factors Affecting The Utilization Of Space By Mice Of The Genus Peromyscus, Howard D. Orr

Journal of the Minnesota Academy of Science

No abstract provided.

Nile Blue Staining Of The Prostate Gland Of Living Mice, Herbert M. Schiller

Biology Honors Papers

This 36 page thesis examines the effect of Nile blue dye on the prostate of the mouse and an attempt to analyze the nature of the visible prostatic granules.

Life History Studies Of The Mouse, Peromyscus Truei Nevadensis, Lowell S. Miller

Theses and Dissertations

Peromyscus truel's a fairly common inhabitant of the upper sonaranlife zone of the Western States. It is an excellent laboratory anlmal with the limitation that captivity must be accompanied by forced activlty, in order to keep the animals within the limits of normal activity. This mouse is polyestrous and breeds from early spring to late fall. Observations have shown pregnancy in late September and in early February. It is the writer's belief that ovulation in the ovary occurs only when copulation has taken lace, because corpora lutea has only been found in pregnant or lactating females. The evidence is scanty …