Digital Commons Network^™

Jim Matthews, Jim Matthews, Meg Miner

All oral histories

Matthews views Myers as a "well-educated liberal arts specialist...who can talk with anybody intelligently about anything that person is interested in." Myers recommended book purchases to Matthews and he summarizes the effect that and conversations about French history had on him. He recounts why and how Myers recruited him to be Dean of Students and describes changes to Student Affairs that followed, what he saw in Cabinet and Board of Trustee meetings about budget decisions, an incidence of racism involving Sodexho (ca 2000), and remarks Myers made on the first anniversary of September 11, 2001 [n.b., there are no recordings …

Rising Tide 2016, Une Office Of Research And Scholarship, Edward Bilsky, Dani Deason, Josh Pahigian, Jennie E. Aranovitch, Laura M. Duffy, Shelly Tallack Caporossi, Marine Miller

Rising Tide

Research and scholarship highlights from University of New England community members. This issue highlights student and faculty research and projects within UNE's College of Arts and Sciences, College of Dental Medicine, College of Osteopathic Medicine, College of Pharmacy, Westbrook College of Health Professions, and projects and research from UNE's Centers for Excellence.

Hypoacetylation, Hypomethylation, And Dephosphorylation Of H2b Histones And Excessive Histone Deacetylase Activity In Du-145 Prostate Cancer Cells, Shundong Cang, Xiaobin Xu, Yuehua Ma, Delong Liu, J W. Chiao

NYMC Faculty Publications

BACKGROUND: Hypoacetylation on histone H3 of human prostate cancer cells has been described. Little is known about the modifications of other histones from prostate cancer cells. METHODS: Histones were isolated from the prostate cancer cell line DU-145 and the non-malignant prostatic cell line RC170N/h. Post-translational modifications of histone H2B were determined by liquid chromatography-mass spectrometry (LC-MS)/MS. RESULTS: The histone H2B of the prostate cancer cell line DU-145 was found to have hypoacetylation, hypomethylation, and dephosphorylation as compared to the non-malignant prostatic cell line RC170N/h. H2B regained acetylation on multiple lysine residues, phosphorylation on Thr19, and methylation on Lys23 and Lys43 …

Misericordia University Faculty Research And Scholarly Work, Misericordia University

University Authors 2015-2016

No abstract provided.

Translational Significance Of Heme Oxygenase In Obesity And Metabolic Syndrome, Nader G. Abraham, Joshua M. Junge, George S. Drummond

NYMC Faculty Publications

The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic syndrome. This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease. The HO system engages with other systems to mitigate the deleterious effects of oxidative stress in obesity and cardiovascular disease (CVD). Recent reports indicate that HO-1/HO-2 protein expression and HO activity have several important roles in hemostasis and reactive oxygen species (ROS)-dependent perturbations associated with metabolic syndrome. HO-1 protects tissue during inflammatory stress in obesity through the degradation of pro-oxidant …

2016 Ruby Yearbook, Briana Keane, Rebecca L. Brown, Phoebe French, Romina Kalmeijer, Faraha Rathod, Taylor Manferdini, Ursinus College Senior Class

The Ruby Yearbooks, 1897-2020

A digitized copy of the 2016 Ruby, the Ursinus College yearbook.

Modification Of Expanded Nk Cells With Chimeric Antigen Receptor Mrna For Adoptive Cellular Therapy, Yaya Chu, Allyson Flower, Mitchell S. Cairo

NYMC Faculty Publications

NK cells are bone marrow-derived cytotoxic lymphocytes that play a major role in the rejection of tumors and cells infected by viruses. The regulation of NK activation vs inhibition is regulated by the expression of a variety of NK receptors (NKRs) and specific NKRs' ligands expressed on their targets. However, factors limiting NK therapy include small numbers of active NK cells in unexpanded peripheral blood and lack of specific tumor targeting. Chimeric antigen receptors (CAR) usually include a single-chain Fv variable fragment from a monoclonal antibody, a transmembrane hinge region, and a signaling domain such as CD28, CD3-zeta, 4-1BB (CD137), …

Nsu Translational Research And Economic Development Fy 2016 Annual Report, Nova Southeastern University

Annual Reports

No abstract provided.

Ω-Amidase: An Underappreciated, But Important Enzyme In L-Glutamine And L-Asparagine Metabolism; Relevance To Sulfur And Nitrogen Metabolism, Tumor Biology And Hyperammonemic Diseases, Arthur J. Cooper, Yevgeniya I. Shurubor, Thambi Dorai, John T. Pinto, Elena P. Isakova, Yulia I. Deryabina, Travis T. Denton, Boris F. Krasnikov

NYMC Faculty Publications

In mammals, two major routes exist for the metabolic conversion of L-glutamine to α-ketoglutarate. The most widely studied pathway involves the hydrolysis of L-glutamine to L-glutamate catalyzed by glutaminases, followed by the conversion of L-glutamate to α-ketoglutarate by the action of an L-glutamate-linked aminotransferase or via the glutamate dehydrogenase reaction. However, another major pathway exists in mammals for the conversion of L-glutamine to α-ketoglutarate (the glutaminase II pathway) in which L-glutamine is first transaminated to α-ketoglutaramate (KGM) followed by hydrolysis of KGM to α-ketoglutarate and ammonia catalyzed by an amidase known as ω-amidase. In mammals, the glutaminase II pathway is …

2016 Nsu Fact Book, Nova Southeastern University

NSU Fact Book

This 24th edition of the Nova Southeastern University Fact Book reflects an expanding body of data and information that provides perspective on the university’s character, growth, and accomplishments.

The 2016 Fact Book includes narrative, numeric, and graphic representation of the university, including history, characteristics, and development of the institution. Data are presented in both tabular and graphic formats to provide pertinent detail, and general trends are highlighted.

Caring Minds, University Of Texas Health Science Center At Houston School Of Nursing

Caring Minds

No abstract provided.

Champions: The Cornerstone Of Pltl Programs, A.E. Dreyfuss

Publications and Research

What drives people to keep working with Peer-Led Team Learning? Such people could be called “champions,” because no matter what the odds, they keep struggling to ensure the continuity of their campus program, promoting expected and unexpected outcomes. Champions are the cornerstone of PLTL programs, because without champions Peer-Led Team Learning would not continue to work

Eet-Dependent Potentiation Of Pulmonary Arterial Pressure: Sex-Different Regulation Of Soluble Epoxide Hydrolase, Sharath Kandhi, Jun Qin, Ghezal Froogh, Houli Jiang, Meng Luo, Michael S. Wolin, An Huang, Dong Sun

NYMC Faculty Publications

We tested the hypothesis that suppression of epoxyeicosatrienoic acid (EET) metabolism via genetic knockout of the gene for soluble epoxide hydrolase (sEH-KO), or female-specific downregulation of sEH expression, plays a role in the potentiation of pulmonary hypertension. We used male (M) and female (F) wild-type (WT) and sEH-KO mice; the latter have high pulmonary EETs. Right ventricular systolic pressure (RVSP) and mean arterial blood pressure (MABP) in control and in response to in vivo administration of U46619 (thromboxane analog), 14,15-EET, and 14,15-EEZE [14,15-epoxyeicosa-5(z)-enoic acid; antagonist of EETs] were recorded. Basal RVSP was comparable among all groups of mice, whereas MABP …

Comparative Effects Of Intranasal Neuropeptide Y And Hs014 In Preventing Anxiety And Depressive-Like Behavior Elicited By Single Prolonged Stress, Esther L. Sabban, Lidia I. Serova, Lishay G. Alaluf, Marcela Laukova, Chandana Peddu

NYMC Faculty Publications

Stress triggered neuropsychiatric disorders are a serious societal problem. Prophylactic treatment or early intervention has great potential in increasing resilience to traumatic stress and reducing its harmful impact. Previously, we demonstrated proof of concept that intranasal administration of neuropeptide Y (NPY) or the melanocortin receptor four (MC4R) antagonist, HS014, prior to single prolonged stress (SPS) rodent post-traumatic stress disorder (PTSD) model, can prevent or attenuate many PTSD associated impairments. Here, we compare effects of NPY or HS014 given 30 min before or immediately after SPS stressors on development of anxiety, depressive-like behavior and associated biochemical abnormalities. SPS triggered anxiety on …

My News

My News (2014-2020)

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Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern faculty continue excellence in 2015

Sexually Dimorphic Phenotype Of Arteriolar Responsiveness To Shear Stress In Soluble Epoxide Hydrolase-Knockout Mice, Jun Qin, Sharath Kandhi, Ghezal Froogh, Houli Jiang, Meng Luo, Dong Sun, An Huang

NYMC Faculty Publications

We hypothesized that potentiating the bioavailability of endothelial epoxyeicosatrienoic acids (EETs) via deletion of the gene for soluble epoxide hydrolase (sEH), or downregulation of sEH expression, enhances flow/shear stress-induced dilator responses (FID) of arterioles. With the use of male (M) and female (F) wild-type (WT) and sEH-knockout (KO) mice, isolated gracilis muscle arterioles were cannulated and pressurized at 80 mmHg. Basal tone and increases in diameter of arterioles as a function of perfusate flow (5, 10, 15, 20, and 25 μl/min) were recorded. The magnitude of FID was significantly smaller and associated with a greater arteriolar tone in M-WT than …

Abt-199 (Venetoclax) And Bcl-2 Inhibitors In Clinical Development, Shundong Cang, Chaitanya Iragavarapu, John Savooji, Yongping Song, Delong Liu

NYMC Faculty Publications

With the advent of new agents targeting CD20, Bruton's tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2) plays a major role in cellular apoptosis and is a druggable target. Small molecule inhibitors of BCL-2 are in active clinical studies. ABT-199 (venetoclax, RG7601, GDC-0199) has been granted breakthrough designation by FDA for relapsed or refractory CLL with 17p deletion. In this review, we summarized the latest clinical development of ABT-199/venetoclax and other novel agents targeting the BCL-2 proteins.

Scholarly Publications By The Faculty Members Of Periyar University, Salem, India: A Scientometric Approach, Natarajan Radhakrishnan, Chandran Velmurugan

Library Philosophy and Practice (e-journal)

The present study aims to bring out the contributions made by the members of various departments of Periyar University, Salem. Further, it views the impact of the scholarly publications produced from Periyar University in India and the data analyzed for the study were retrieved from Web of Science (WOS) database for a period from 1998 to 2014. The study focuses on publishing trend, authorship pattern, and type of documents, country wise distribution of authors and individual authors’ research publications and their TLCS, TCLS, TLCR and so on.

Research And Creative Activity July 1, 2014 – June 30, 2015: Major Sponsored Programs And Faculty Awards For Research And Creativity, Elizabeth Banset

Office of Research and Economic Development: Publications

No abstract provided.

Β-Hydroxybutyrate Attenuates Nmda-Induced Spasms In Rats With Evidence Of Neuronal Stabilization On Mr Spectroscopy, Mi-Sun Yum, Minyoung Lee, Dong-Cheol Woo, Dong Wook Kim, Tae-Sung Ko, Libor Velíšek

NYMC Faculty Publications

BACKGROUND: Infantile spasms (IS) is a devastating epileptic encephalopathy. The ketogenic diet (KD) has been successfully used as a treatment for IS. This study was designed to test whether beta-hydroxybutyrate (BHB), a major metabolite of the KD, is effective in an animal model of IS. METHODS: Pregnant rats received betamethasone on gestational day 15. The offspring received either single [30min prior to NMDA-triggered spasms on postnatal day (P) 15] or prolonged (three per day from P12 to P15) i.p. BHB. An additional experiment used repeated bouts of spasms on P12, P13, and P15 with randomized prolonged BHB treatment initiated after …

Caveolin-1 Deficiency Inhibits The Basolateral K+ Channels In The Distal Convoluted Tubule And Impairs Renal K+ And Mg2+ Transport, Lijun Wang, Chengbiao Zhang, Xiaotong Su, Dao-Hong Lin, Wenhui Wang

NYMC Faculty Publications

Kcnj10 encodes the inwardly rectifying K(+) channel Kir4.1 in the basolateral membrane of the distal convoluted tubule (DCT) and is activated by c-Src. However, the regulation and function of this K(+) channel are incompletely characterized. Here, patch-clamp experiments in Kcnj10-transfected HEK293 cells demonstrated that c-Src-induced stimulation of Kcnj10 requires coexpression of caveolin-1 (cav-1), and immunostaining showed expression of cav-1 in the basolateral membrane of parvalbumin-positive DCT. Patch-clamp experiments detected a 40-pS inwardly rectifying K(+) channel, a heterotetramer of Kir4.1/Kir5.1, in the basolateral membrane of the early DCT (DCT1) in both wild-type (WT) and cav-1-knockout (KO) mice. However, the activity of …

Vasopressin-Induced Stimulation Of The Na(+)-Activated K(+) Channels Is Responsible For Maintaining The Basolateral K(+) Conductance Of The Thick Ascending Limb (Tal) In East/Sesame Syndrome, Lili Fan, Xiaoyan Wang, Dandan Zhang, Xinpeng Duan, Chunlei Zhao, Mingxue Zu, Xinxin Meng, Chengbiao Zhang, Xiao-Tong Su, Ming-Xiao Wang, Wen-Hui Wang, Ruimin Gu

NYMC Faculty Publications

The renal phenotype of EAST syndrome, a disease caused by the loss-of-function-mutations of Kcnj10 (Kir4.1), is a reminiscence of Gitelman's syndrome characterized by the defective function in the distal convoluted tubule (DCT). The aim of the present study is to test whether antidiuretic hormone (vasopressin)-induced stimulation of the Na(+)-activated 80-150pS K(+) channel is responsible for compensating the lost function of Kcnj10 in the thick ascending limb (TAL) of subjects with EAST syndrome. Immunostaining and western blot showed that the expression of aquaporin 2 (AQP2) was significantly higher in Kcnj10(-/-) mice than those of WT littermates, suggesting that the disruption of …

Suppression Of Spreading Depolarization And Stabilization Of Dendritic Spines By Glyx-13, An Nmda Receptor Glycine-Site Functional Partial Agonist, Xiao-Lei Zhang, C William Shuttleworth, Joseph R. Moskal, Patric K. Stanton

NYMC Faculty Publications

Cortical spreading depolarization (SD) is a slow self-propagating wave of mass cellular depolarization in brain tissue, thought to be the underlying cause of migraine scintillating scotoma and aura, and associated with stroke, traumatic brain injury, and termination of status epilepticus. The N-methyl-d-aspartate subtype of glutamate receptor (NMDAR), which gates influx of calcium and is an important trigger of long-term synaptic plasticity, is also a contributor to the initiation and propagation of SD. The current study tested the potential of pharmacological modulation of NMDAR activity through the obligatory co-agonist binding site, to suppress the initiation of SD, and modulate the effects …

Public Health Impact Of Strain Specific Immunity To Borrelia Burgdorferi, Camilo E. Khatchikian, Robert B. Nadelman, John Nowakowski, Ira Schwartz, Michael Z. Levy, Dustin Brisson, Gary P. Wormser

NYMC Faculty Publications

BACKGROUND: Lyme disease, caused by Borrelia burgdorferi, is the most common tick-borne infection in the United States. Although humans can be infected by at least 16 different strains of B. burgdorferi, the overwhelming majority of infections are due to only four strains. It was recently demonstrated that patients who are treated for early Lyme disease develop immunity to the specific strain of B. burgdorferi that caused their infection. The aim of this study is to estimate the reduction in cases of Lyme disease in the United States that may occur as a result of type specific immunity. METHODS: The analysis …

Guide To The Dr. Jane Claire Dirks-Edmunds Papers, Linfield College Archives

Linfield Archives Finding Aids

This collection reflects the life work of Dr. Jane Claire Dirks-Edmunds, a student and professor of Linfield College. A dedicated and scrupulous woman, the majority of the collection consists of her research, teaching materials, and correspondence. The collection also includes research and correspondence by Dr. Jane Claire Dirks-Edmunds’s mentor, Dr. James A. Macnab.

The Loop (Fall 2015), Taylor University

The Loop (2012-2017)

The late Fall 2015 edition of Taylor University’s The Loop.

Social Media In The Dental School Environment, Part A: Benefits, Challenges, And Recommendations For Use, Heiko Spallek, Sharon P. Turner, Evelyn Donate-Bartfield, David Chambers, Maureen Mcandrew, Pamela Zarkowski, Nadeem Karimbux

Oral Health Practice Faculty Publications

Social media consist of powerful tools that impact not only communication but relationships among people, thus posing an inherent challenge to the traditional standards of who we are as dental educators and what we can expect of each other. This article examines how the world of social media has changed dental education. Its goal is to outline the complex issues that social media use presents for academic dental institutions and to examine these issues from personal, professional, and legal perspectives. After providing an update on social media, the article considers the advantages and risks associated with the use of social …

Reduced Toxicity Conditioning And Allogeneic Hematopoietic Progenitor Cell Transplantation For Recessive Dystrophic Epidermolysis Bullosa, Mark B. Geyer, Kavita Radhakrishnan, Roger Giller, Noriko Umegaki, Sivan Harel, Maija Kiuru, Kimberly D. Morel, Nicole Leboeuf, Jessica Kandel, Anna Bruckner, Sandra Fabricatore, Mei Chen, David Woodley, John Mcgrath, Leeann Baxter-Lowe, Jouni Uitto, Angela M. Christiano, Mitchell S. Cairo

NYMC Faculty Publications

Recessive dystrophic epidermolysis bullosa is a severe, incurable, inherited blistering disease caused by COL7A1 mutations. Emerging evidence suggests hematopoietic progenitor cells (HPCs) can be reprogrammed into skin; HPC-derived cells can restore COL7 expression in COL7-deficient mice. We report two children with recessive dystrophic epidermolysis bullosa treated with reduced-toxicity conditioning and HLA-matched HPC transplantation.

Host Switching Vs. Host Sharing In Overlapping Sylvatic Trypanosoma Cruzi Transmission Cycles, Christopher Kribs, Christopher Mitchell

Mathematics Faculty Publications - Archive

The principle of competitive exclusion is well established for multiple populations competing for the same resource, and simple models for multistrain infection exhibit it as well when cross-immunity precludes coinfections. However, multiple hosts provide niches for different pathogens to occupy simultaneously. This is the case for the vector-borne parasite Trypanosoma cruzi in overlapping sylvatic transmission cycles in the Americas, where it is enzootic. This study uses cycles in the USA involving two different hosts but the same vector species as a context for the study of the mechanisms behind the communication between the two cycles. Vectors dispersing in search of …