Digital Commons Network^™

Oscillatory Cerebral Blood Flow Is Associated With Impaired Neurocognition And Functional Hyperemia In Postural Tachycardia Syndrome During Graded Tilt, Julian M. Stewart, Andrew T. Del Pozzi, Akash Pandey, Zachary R. Messer, Courtney Terilli, Marvin S. Medow

NYMC Faculty Publications

We hypothesize that upright cognitive impairment in patients with postural tachycardia syndrome (POTS) is caused by reduced cerebral blood flow (CBF). The CBF velocity (CBF(v)) measured by transcranial Doppler ultrasound decreased excessively during 70° tilt in a minority of patients with intermittent hyperpnea/hypocapnia. Incremental tilt showed no difference in mean CBF(v). But N-back memory tasking indicated progressive compromised memory, reduced functional hyperemia, and reduced neurovascular coupling. Orthostasis caused slow oscillations in CBF(v) linked to oscillations in arterial pressure in patients with POTS. We also hypothesize that oscillatory CBF(v) degrades neurovascular coupling. We performed 2-back testing when subjects were in supine …

Novel Alk Inhibitors In Clinical Use And Development, Chaitanya Iragavarapu, Milaim Mustafa, Akintunde Akinleye, Muhammad Furqan, Varun Mittal, Shundong Cang, Delong Liu

NYMC Faculty Publications

Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. ALK-1 was initially found in anaplastic large cell lymphoma (ALCL). ALK mutations have also been implicated in the pathogenesis of non-small cell lung cancer (NSCLC) and other solid tumors. Multiple small molecule inhibitors with activity against ALK and related oncoproteins are under clinical development. Two of them, crizotinib and ceritinib, have been approved by FDA for treatment of locally advanced and metastatic NSCLC. More agents (alectinib, ASP3026, X396) with improved safety, selectivity, and potency are in the pipeline. Dual inhibitors targeting ALK and EGFRm (AP26113), …

2015 February 17, Faculty Senate Minutes, State Univerity Of New York College At Cortland

Minutes

Faculty Senate Minutes No. 9, February 17, 2015

From Ivory To Babel To A New Foundation, Richard Boris

Journal of Collective Bargaining in the Academy

During my 12 years at the NationalCenter for Collective Bargaining in Higher Education and the Professions, I observed with increasing frustration the inability of administration and faculty leaders—union and governance—to fully grasp, analyze, and find pathways out of public higher education’s current existential crisis.

My many years of observing leaders of public higher education lead me to the inescapable conclusion that together the leaders share a culture that shorts strategic planning, thinking, and boldness and instead favors ad-hoc, incremental acceptance of the ever-changing, slimmed-down state of affairs. The rarified bubbles of presidential cabinets and union boards symbiotically promote policies that, …

Development Of High Yield Reassortants For Influenza Type B Viruses And Analysis Of Their Gene Compositions, Jianhua Le, Edward J. Orff, Andrew A. Fulvini, Liling Huang, Shiroh Onodera, Barbara A. Pokorny, Andrew Malewicz, Patricia Primakov, Doris J. Bucher

NYMC Faculty Publications

A critical step in producing the annual inactivated influenza vaccine is the development of high yield (hy) seed viruses by reassortment for improved growth in ovo. Although hy reassortants for type A influenza viruses have been developed for many years, hy B influenza reassortant virus development for vaccine production has proven difficult. In this study, we have developed fourteen hy influenza type B reassortants as vaccine candidate strains with B/Lee/40 as the donor virus. Upon characterization by the Influenza Division at the Centers for Disease Control and Prevention (CDC) and the verification of HA by sequencing, all B reassortants were …

School Of Nursing News, Georgia Southern University

Nursing: News & Publications (2013-2023)

• Visiting Faculty Lecture: Dr. Kit Chesla, The Thrill of Discovery: Qualitative Research Approaches

Access Disparity And Health Inequality Of The Elderly: Unmet Needs And Delayed Healthcare, Tetsuji Yamada, Chia-Ching Chen, Chiyoe Murata, Hiroshi Hirai, Toshiyuki Ojima, Katsunori Kondo, Joseph R. Harris

NYMC Faculty Publications

The purpose of this study is to investigate healthcare access disparity that will cause delayed and unmet healthcare needs for the elderly, and to examine health inequality and healthcare cost burden for the elderly. To produce clear policy applications, this study adapts a modified PRECEDE-PROCEED model for framing theoretical and experimental approaches. Data were collected from a large collection of the Community Tracking Study Household Survey 2003-2004 of the USA. Reliability and construct validity are examined for internal consistency and estimation of disparity and inequality are analyzed by using probit/ols regressions. The results show that predisposing factors (e.g., attitude, beliefs, …

What Is New In Exercise In Pregnancy? Best Articles From The Past Year, Howard A. Blanchette

NYMC Faculty Publications

This month we focus on current research in exercise in pregnancy. Dr. Blanchette discusses four recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along with direct links to the abstracts.

Induction Of Indoleamine 2,3-Dioxygenase By Borrelia Burgdorferi In Human Immune Cells Correlates With Pathogenic Potential, Andrea C. Love, Ira Schwartz, Mary M. Petzke

NYMC Faculty Publications

Borrelia burgdorferi, the bacterial agent of Lyme disease, induces the production of type I IFNs by human DCs through TLR7 and TLR9 signaling. This type I IFN response occurs in a genotype-dependent manner, with significantly higher levels of IFN-α elicited by B. burgdorferi strains that have a greater capacity for causing disseminated infection. A B. burgdorferi strain that was previously shown to induce IFN-α was found to elicit significantly higher levels of IDO1 protein and its downstream metabolite, kynurenine, compared with a B. burgdorferi mutant that lacks a single linear plasmid (lp36); this mutant is unable to induce IFN-α and …

Long-Term Assessment Of Fatigue In Patients With Culture-Confirmed Lyme Disease, Gary P. Wormser, Erica Weitzner, Donna Mckenna, Robert B. Nadelman, Carol Scavarda, John Nowakowski

NYMC Faculty Publications

BACKGROUND: Fatigue is a common symptom with numerous causes. Severe fatigue is thought to be an important manifestation of post-treatment Lyme disease syndrome. The frequency with which severe fatigue occurs as a long-term sequela in prospectively followed patients with Lyme disease is unknown. METHODS: Patients with culture-confirmed Lyme disease who originally presented with erythema migrans have been evaluated annually in a prospective study to determine their long-term outcome. In 2011-2013, subjects were evaluated for fatigue using an 11-item Fatigue Severity Scale (FSS-11) that has been used in studies of post-treatment Lyme disease syndrome. An FSS-11 score of ≥4.0 is indicative …

Microrna-146a And Microrna-146b Regulate Human Dendritic Cell Apoptosis And Cytokine Production By Targeting Traf6 And Irak1 Proteins, Haein Park, Xin Huang, Changming Lu, Mitchell S. Cairo, Xianzheng Zhou

NYMC Faculty Publications

We have previously reported 27 differentially expressed microRNAs (miRNAs) during human monocyte differentiation into immature dendritic cells (imDCs) and mature DCs (mDCs). However, their roles in DC differentiation and function remain largely elusive. Here, we report that microRNA (miR)-146a and miR-146b modulate DC apoptosis and cytokine production. Expression of miR-146a and miR-146b was significantly increased upon monocyte differentiation into imDCs and mDCs. Silencing of miR-146a and/or miR-146b in imDCs and mDCs significantly prevented DC apoptosis, whereas overexpressing miR-146a and/or miR-146b increased DC apoptosis. miR-146a and miR-146b expression in imDCs and mDCs was inversely correlated with TRAF6 and IRAK1 expression. Furthermore, …

Role Of Homocysteinylation Of Ace In Endothelial Dysfunction Of Arteries, An Huang, John T. Pinto, Ghezal Froogh, Sharath Kandhi, Jun Qin, Michael S. Wolin, Thomas H. Hintze, Dong Sun

NYMC Faculty Publications

The direct impact of de novo synthesis of homocysteine (Hcy) and its reactive metabolites, Hcy-S-S-Hcy and Hcy thiolactone (HCTL), on vascular function has not been fully elucidated. We hypothesized that Hcy synthesized within endothelial cells affects activity of angiotensin-converting enzyme (ACE) by direct homocysteinylation of its amino- and/or sulfhydryl moieties. This covalent modification enhances ACE reactivity toward angiotensin II (ANG II)-NADPH oxidase-superoxide-dependent endothelial dysfunction. Mesenteric and coronary arteries isolated from normal rats were incubated for 3 days with or without exogenous methionine (Met, 0.1-0.3 mM), a precursor to Hcy. Incubation of arteries in Met-free media resulted in time-dependent decreases in …

Faculty Development For Service-Learning: One Size Does Not Fit All, Lynn E. Pelco, Catherine Howard

Division of Community Engagement Resources

This conference presentation describes the development of the professional development continuum currently being used at Virginia Commonwealth University to build the faculty’s capacity for teaching high-quality service-learning courses. Our professional development continuum was developed over the past 5 years by the staff of the VCU Service-Learning Office and was informed by program evaluation data, the principles of adult learning theory, and an “exposure-experience-expertise” developmental framework. The continuum targets instructors at varying levels of service-learning knowledge and experience so that faculty instructors with more service-learning experience participate in different professional development opportunities than do instructors who are new to the pedagogy.

Antiarrhythmic Properties Of Ranolazine: A Review Of The Current Evidence, Tanush Gupta, Sahil Khera, Dhaval Kolte, Wilbert S. Aronow, Sei Iwai

NYMC Faculty Publications

Ranolazine was developed as an antianginal agent and was approved by the Food and Drug Administration in 2006 for use in chronic stable angina pectoris. Experimental and clinical studies have shown that it also has antiarrhythmic properties based on the frequency-dependent blockade of peak sodium channel current (peak INa) and rapidly activating delayed rectifier potassium current (IKr) in the atria and blockade of late phase of the inward sodium current (late INa) in the ventricles. Recent clinical studies have revealed the efficacy of ranolazine in prevention of atrial fibrillation in patients with acute coronary syndromes, prevention as well as conversion …

Agonists Of Epoxyeicosatrienoic Acids Reduce Infarct Size And Ameliorate Cardiac Dysfunction Via Activation Of Ho-1 And Wnt1 Canonical Pathway, Jian Cao, Peter L. Tsenovoy, Ellen A. Thompson, John R. Falck, Robert Touchon, Komal Sodhi, Rita Rezzani, Joseph I. Shapiro, Nader G. Abraham

NYMC Faculty Publications

Myocardial infarction (MI) is complicated by ventricular fibrosis and associated diastolic and systolic failure. Emerging studies implicate Wnt1 signaling in the formation of new blood vessels. Epoxyeicosatrienoic acids (EETs)-mediated up-regulation of heme oxygenase-1 (HO-1) protects against the detrimental consequences of MI in several animal models, however, the mechanism(s) by which this occurs remains unclear. The aim of this study was to examine these mechanisms in the LAD ligation animal model of post infarcted heart failure. Specifically, we sought to clarify the mechanistic basis of the interactions of the Wnt1 canonical pathway, HO-1 and associated angiogenesis. Human microvascular endothelial cells (HMECs) …

Heme Oxygenase-2 Deletion Impairs Macrophage Function: Implication In Wound Healing, Lars Bellner, Giuseppina Marrazzo, Nico Van Rooijen, Michael W. Dunn, Nader G. Abraham, Michal L. Schwartzman

NYMC Faculty Publications

Heme oxygenase (HO)-2 deficiency impairs wound healing and exacerbates inflammation following injury. We examine the impact of HO-2 deficiency on macrophage function and the contribution of macrophage HO-2 to inflammatory and repair responses to injury. Corneal epithelial debridement was performed in control and macrophage-depleted HO-2(-/-) and wild-type (WT) mice and in bone marrow chimeras. Peritoneal macrophages were collected for determination of phagocytic activity and classically activated macrophage (M1)-alternatively activated macrophage (M2) polarization. Depletion of macrophages delayed corneal healing (13.2%) and increased neutrophil infiltration (54.1%) by day 4 in WT mice, whereas in HO-2(-/-) mice, it did not worsen the already …

2015 Ruby Yearbook, Ayesha Contractor, Lisa Abraham, Rebecca L. Brown, Megan Burns, Hannah Engber, Phoebe French, Romina Kalmeijer, Delanie Lalor, Monica Reuman '15, Ursinus College Senior Class

The Ruby Yearbooks, 1897-2020

A digitized copy of the 2015 Ruby, the Ursinus College yearbook.

Striking A Balance, Edward C. Halperin

NYMC Faculty Publications

No abstract provided.

Live Virus Vaccines Based On A Yellow Fever Vaccine Backbone: Standardized Template With Key Considerations For A Risk/Benefit Assessment, Thomas P. Monath, Stephen J. Seligman, James S. Robertson, Bruno Guy, Edward B. Hayes, Richard C. Condit, Jean Louis Excler, Lisa Marie Mac, Baevin Carbery, Robert T. Chen

NYMC Faculty Publications

The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety of live, recombinant viral vaccines incorporating genes from heterologous viruses inserted into the backbone of another virus (so-called "chimeric virus vaccines"). Many viral vector vaccines are in advanced clinical trials. The first such vaccine to be approved for marketing (to date in Australia, Thailand, Malaysia, and the Philippines) is a vaccine against the flavivirus, Japanese encephalitis (JE), which employs a licensed vaccine (yellow fever 17D) as a vector. In this vaccine, two envelope proteins (prM-E) of YF 17D virus were exchanged for the corresponding …

Distinct Signaling Mechanisms Of Mtorc1 And Mtorc2 In Glioblastoma Multiforme: A Tale Of Two Complexes, Meena Jhanwar-Uniyal, John L. Gillick, Jayson Neil, Michael Tobias, Zachary E. Thwing, Raj Murali

NYMC Faculty Publications

Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that functions via two multiprotein complexes, namely mTORC1 and mTORC2, each characterized by different binding partners that confer separate functions. mTORC1 function is tightly regulated by PI3-K/Akt and is sensitive to rapamycin. mTORC2 is sensitive to growth factors, not nutrients, and is associated with rapamycin-insensitivity. mTORC1 regulates protein synthesis and cell growth through downstream molecules: 4E-BP1 (also called EIF4E-BP1) and S6K. Also, mTORC2 is thought to modulate growth factor signaling by phosphorylating the C-terminal hydrophobic motif of some AGC kinases such as Akt and SGK. Recent evidence has suggested that mTORC2 …

The Experiences Of African-Born Women Faculty And Administrators At Colleges And Universities In The United States, Oyibo H. Afoaku

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this study was to document the experiences of African-born women faculty and administrators at colleges and universities in the United States. The study explored the factors that motivated African-born women to immigrate to and extend their stay in the United States beyond completion of their Education; factors they perceive as constraint on their quest for self-empowerment and identity as foreign students, college instructors, and/or administrators, and parents; and factors that have enabled them to adapt to their host culture and achieve their Educational and professional goals even though they had to contend with multiple challenges associated with …

Volume 3, 2015, Csusb

Psychology Student Research Journal (PSRJ)

• Information about the Psychology Student Research Journal p.1
• Letter from the Journal President p.2
  Ryan L. Radmall
• Letter from the Editor-in-Chief p.3
  Lace M. Riggs
• Words of Wisdom from a College Chair: A Brief Biography and Interview with Dean Jamal Nassar p.4
• Infidelity and HIV in South Africa p.6
  Kamalpreet K. Padda
• Nothing to LOL About: Texting (Mis)communications in Intimate Relationships p.11
  Kirk Fortini
• 2014-2015 Student Conference Presentations p.17
• The Influence of Emotion Regulation Strategies in the Relationship between Social Support and Posttramatic Stress Disorder Symptoms among Survivors of Sexual Assault p.20
  Seallong Sechang, Jason Alipio, Monica Aguilar, and Christina …

Rising Tide 2015, Une Office Of Research And Scholarship, Edward Bilsky, Annie Leslie, Josh Pahigian, Jennie E. Aranovitch, Laura M. Duffy, Marine Miller

Rising Tide

Research and scholarship highlights from University of New England community members. This issue highlights in particular: student and faculty research and projects within UNE's College of Arts and Sciences, College of Osteopathic Medicine, Westbrook College of Health Professions, and projects and research from UNE's Centers for Excellence.

Differential Proteomic Analysis Of Endemic And Sporadic Epstein-Barr Virus-Positive And Negative Burkitt Lymphoma, Nader Kim El-Mallawany, Nancy Day, Janet Ayello, Carmella Van De Ven, Kevin Conlon, Damian Fermin, Venkatesha Basrur, Kojo Elenitoba-Johnson, Megan Lim, Mitchell S. Cairo

NYMC Faculty Publications

BACKGROUND: Burkitt lymphoma (BL) is the most common non-Hodgkin lymphoma in children worldwide and the most common paediatric malignancy in sub-Saharan Africa. The endemic (eBL) and sporadic (sBL) variants have distinct epidemiologic and virologic characteristics. Although gene expression studies have defined the transcriptional profiles of both, their proteomic signatures have not been studied. METHODS: We compared the proteomic expression profiles using differential mass spectrometry-based isotope tag for relative and absolute quantitation (iTRAQ) analysis of a cell line representing Epstein-Barr virus (EBV)+ eBL, EBV+ and EBV- sBL, and EBV+/- normal B cells from healthy donors. RESULTS: In total, there were 144 …

Androgen-Induced Hypertension In Angiotensinogen Deficient Mice: Role Of 20-Hete And Eets, Victor Garcia, Jennifer Cheng, Adam Weidenhammer, Yan Ding, Cheng-Chia Wu, Fan Zhang, Katherine Gotlinger, John R. Falck, Michal L. Schwartzman

NYMC Faculty Publications

20-HETE is a potent inducer of endothelial ACE in vitro and administration of lisinopril or losartan attenuates blood pressure in models of 20-HETE-dependent hypertension. The present study was undertaken to further define the relationship between 20-HETE and the renin-angiotensin system in hypertension using an angiotensinogen-deficient mouse (Agt+/-). Treatment of male AGT+/- with 5α-dihydrotestosterone (DHT) increased systolic BP from 102±2 to 125±3mmHg; in comparison, the same treatment raised BP in wild type (WT) from 110±2 to 138±2mmHg. DHT increased vascular 20-HETE levels in AGT+/- and WT from 1.5±0.7 and 2.1±0.6 to 13.0±2.0 and 15.8±4.0ng/mg, respectively. Concurrent treatment with the 20-HETE antagonist, …

Fact Book, 2015-16, John Carroll University

Fact Book

2015-16 Fact book

Research Brief Fiscal Year 2015, Nova Southeastern University

Research Briefs

No abstract provided.

Nsu Office Of Research And Technology Transfer Fy 2015 Annual Report, Nova Southeastern University

Annual Reports

No abstract provided.

Nova Southeastern University 2015 Annual Report, Nova Southeastern University

NSU Annual Reports

No abstract provided.

Winter 2015, College Of The Pacific

History News

No abstract provided.