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Pacific Review Summer 2015, Alumni Association Of The University Of The Pacific Jun 2015

Pacific Review Summer 2015, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

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Kcnj10 (Kir4.1) Is Expressed In The Basolateral Membrane Of The Cortical Thick Ascending Limb, Chengbiao Zhang, Lijun Wang, Xiao-Tong Su, Dao-Hong Lin, Wen-Hui Wang Jun 2015

Kcnj10 (Kir4.1) Is Expressed In The Basolateral Membrane Of The Cortical Thick Ascending Limb, Chengbiao Zhang, Lijun Wang, Xiao-Tong Su, Dao-Hong Lin, Wen-Hui Wang

NYMC Faculty Publications

The aim of the present study is to examine the role of Kcnj10 (Kir.4.1) in contributing to the basolateral K conductance in the cortical thick ascending limb (cTAL) using Kcnj10(+/+) wild-type (WT) and Kcnj10(-/-) knockout (KO) mice. The patch-clamp experiments detected a 40- and an 80-pS K channel in the basolateral membrane of the cTAL. Moreover, the probability of finding the 40-pS K was significantly higher in the late part of the cTAL close to the distal convoluted tubule than those in the initial part. Immunostaining showed that Kcnj10 staining was detected in the basolateral membrane of the cTAL but …

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Update And Commentary On Four Emerging Tick-Borne Infections: Ehrlichia Muris-Like Agent, Borrelia Miyamotoi, Deer Tick Virus, Heartland Virus, And Whether Ticks Play A Role In Transmission Of Bartonella Henselae, Gary P. Wormser, Bobbi Pritt Jun 2015

Update And Commentary On Four Emerging Tick-Borne Infections: Ehrlichia Muris-Like Agent, Borrelia Miyamotoi, Deer Tick Virus, Heartland Virus, And Whether Ticks Play A Role In Transmission Of Bartonella Henselae, Gary P. Wormser, Bobbi Pritt

NYMC Faculty Publications

Emerging tick-borne infections continue to be observed in the United States and elsewhere. Current information on the epidemiology, clinical and laboratory features, and treatment of infections due to Ehrlichia muris-like agent, deer tick virus, Borrelia miyamotoi sensu lato, and Heartland virus was provided and critically reviewed. More research is needed to define the incidence and to understand the clinical and the laboratory features of these infections. There is also a growing need for the development of sensitive and specific serologic and molecular assays for these infections that are easily accessible to clinicians.

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Comparison Of A Quantitative Pcr Assay With Peripheral Blood Smear Examination For Detection And Quantitation Of Babesia Microti Infection In Humans, Guiqing Wang, Patrick Villafuerte, Jian Zhuge, Paul Visintainer, Gary P. Wormser Jun 2015

Comparison Of A Quantitative Pcr Assay With Peripheral Blood Smear Examination For Detection And Quantitation Of Babesia Microti Infection In Humans, Guiqing Wang, Patrick Villafuerte, Jian Zhuge, Paul Visintainer, Gary P. Wormser

NYMC Faculty Publications

Using a real-time quantitative PCR (qPCR), we determined the number of DNA copies/mL of blood of a Babesia microti gene in infected patients. Thirty-six patients (whose median age was 62.5years and 75.0% were male) with at least 1 qPCR-positive blood sample were included in this analysis, including 16 with serial blood samples. Based on testing of serial blood samples, it could be demonstrated that the smear became negative while the qPCR remained positive. A moderate to strong correlation was found between the DNA copy number and the number of infected erythrocytes per milliliter of blood (Pearson's r=0.68, P<0.001). Based on limited data, the DNA copy number fell by a mean of 4.1-12.9% per day on active treatment and by 3.5-7.1% per day off therapy. qPCR methodology may permit systematic evaluations of the relative efficacy of various antiparasitic drug regimens and other therapeutic modalities, although a limitation of such testing is that DNA detection per se does not establish the presence of viable parasites.

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Confronting The Nursing Faculty Shortage: Identifying Solutions To Address The Issue, Stacy Ann Emerson May 2015

Confronting The Nursing Faculty Shortage: Identifying Solutions To Address The Issue, Stacy Ann Emerson

Student Theses and Dissertations

Recently there has been much attention focused on the shortage of nurses in the United States with an anticipated deficit in excess of one million registered nurses by 2020. Practical and theoretical explanations for the shortage often cite a lack of nursing faculty as a contributing factor to the crisis. Each year, thousands of qualified students are denied admission to nursing schools across the nation, in large part due to lack of faculty and clinical resources. Although economic, social, and financial motivators may provide clues as to why so few nurses pursue faculty lines, solutions for reversing the trend, such …

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Rwu School Of Law Commencement (May 15, 2015), Roger Williams University School Of Law May 2015

Rwu School Of Law Commencement (May 15, 2015), Roger Williams University School Of Law

School of Law Commencement (1996- )

No abstract provided.

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2015 Great Expectations Spring Faculty Conference: General Education, Academic Affairs May 2015

2015 Great Expectations Spring Faculty Conference: General Education, Academic Affairs

Spring Great Expectation Faculty Conference

The 2015 Great Expectations Spring Faculty Conference features a keynote speech by Kathleen Blake Yancey. Kathleen Blake Yancey is Kellogg W. Hunt Professor of English and Distinguished Research Professor at Florida State University. A (past) president of several scholarly organizations--among them the National Council of Teachers of English and the Council of Writing Program Administrators (CWPA)--she co-founded and co-edited Assessing Writing for seven years, and she just stepped down from her five-year term as Editor of College Composition and Communication. She is the author of numerous articles, book chapters, and twelve books—including Portfolios in the Writing Classroom; Delivering College Composition: …

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Long-Term Methionine-Diet Induced Mild Hyperhomocysteinemia Associated Cardiac Metabolic Dysfunction In Multiparous Rats, Su Song, Elizabeth Kertowidjojo, Caroline Ojaimi, Beatriz Martin-Fernandez, Sharath Kandhi, Michael Wolin, Thomas H. Hintze May 2015

Long-Term Methionine-Diet Induced Mild Hyperhomocysteinemia Associated Cardiac Metabolic Dysfunction In Multiparous Rats, Su Song, Elizabeth Kertowidjojo, Caroline Ojaimi, Beatriz Martin-Fernandez, Sharath Kandhi, Michael Wolin, Thomas H. Hintze

NYMC Faculty Publications

Mild hyperhomocysteinemia (HHcy, clinically defined as less than 30 μmol/L) is an independent cardiovascular disease (CVD) risk factor, and is associated with many complications during pregnancy, such as preeclampsia (PE). The aim of this study was to assess the effect of long-term mild HHcy on cardiac metabolic function of multiparous rats. Female rats were mated 3 to 4 times and were fed with methionine in drinking water to increase plasma Hcy (2.9 ± 0.3 to 10.5 ± 2.3 μmol/L) until termination. This caused significant increase of heart weight/body weight (0.24 ± 0.01 to 0.27 ± 0.01 g/100 g) and left …

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Combined Diazepam And Mk-801 Therapy Provides Synergistic Protection From Tetramethylenedisulfotetramine-Induced Tonic-Clonic Seizures And Lethality In Mice, Michael P. Shakarjian, Mahil S. Ali, Jana Velíšková, Patric K. Stanton, Diane E. Heck, Libor Velíšek May 2015

Combined Diazepam And Mk-801 Therapy Provides Synergistic Protection From Tetramethylenedisulfotetramine-Induced Tonic-Clonic Seizures And Lethality In Mice, Michael P. Shakarjian, Mahil S. Ali, Jana Velíšková, Patric K. Stanton, Diane E. Heck, Libor Velíšek

NYMC Faculty Publications

The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and highly lethal GABA-gated Cl(-) channel blocker. TMDT is clandestinely produced, remains popular in mainland China, and causes numerous unintentional and deliberate poisonings worldwide. TMDT is odorless, tasteless, and easy to manufacture, features that make it a potential weapon of terrorism. There is no effective treatment. We previously characterized the effects of TMDT in C57BL/6 mice and surveyed efficacies of GABAergic and glutamatergic anticonvulsant treatments. At 0.4 mg/kg i.p., TMDT produced neurotoxic symptomatology consisting of twitches, clonic and tonic-clonic seizures, often progressing to status epilepticus and death. If administered immediately after the …

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Breaking The Barriers: New Role For Insulin-Like Growth Factor 1 Receptor In Vascular Permeability, Sandhya Xavier May 2015

Breaking The Barriers: New Role For Insulin-Like Growth Factor 1 Receptor In Vascular Permeability, Sandhya Xavier

NYMC Faculty Publications

This commentary highlights the article by Liang et al that describes a critical role for insulin-like growth factor 1 receptor in the progression of chronic kidney disease.

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Azilsartan Is Associated With Increased Circulating Angiotensin-(1-7) Levels And Reduced Renovascular 20-Hete Levels, Mairéad A. Carroll, Younjung Kang, Praveen N. Chander, Charles T. Stier May 2015

Azilsartan Is Associated With Increased Circulating Angiotensin-(1-7) Levels And Reduced Renovascular 20-Hete Levels, Mairéad A. Carroll, Younjung Kang, Praveen N. Chander, Charles T. Stier

NYMC Faculty Publications

BACKGROUND: Activation of angiotensin (ANG) II type 1 receptors (AT1R) promotes vasoconstriction, inflammation, and renal dysfunction. In this study, we addressed the ability of azilsartan (AZL), a new AT1R antagonist, to modulate levels of plasma ANG-(1-7) and renal epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE). METHODS: Sprague-Dawley rats were infused with ANG II (125 ng/min) or vehicle (VEH). AZL (3 mg/kg/day) or VEH was administered starting 1 day prior to ANG II or VEH infusion. On day 10, plasma was obtained for measurement of ANG-(1-7) and kidneys for isolation of microvessels for EET and 20-HETE determination and histological evaluation. RESULTS: …

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Pharmacists In Primary Care, William H. Frishman May 2015

Pharmacists In Primary Care, William H. Frishman

NYMC Faculty Publications

No abstract provided.

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Dr. Jessie Wilkerson Wins Award For Best Dissertation, Admin Apr 2015

Dr. Jessie Wilkerson Wins Award For Best Dissertation, Admin

Blog Posts

We're excited to congratulate faculty member Dr. Jessie Wilkerson, who just won an award for her UNC dissertation, "Where Movements Meet: Women's Activism in the Appalachian South, 1965-1980." The Lerner-Scott Prize from the Organization of American Historians is awarded for the best dissertation in US women's history.

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Spring 2015 Personally Speaking: Why Do We Do It?, Blake Henson Apr 2015

Spring 2015 Personally Speaking: Why Do We Do It?, Blake Henson

St. Norbert College Magazine 2013-2018

The “Personally Speaking/Why Do We Do It?” article from St. Norbert College Magazine’s Spring 2015 issue features a reflective essay by music professor Blake Henson, exploring the deeper motivations behind teaching and learning. Henson offers a heartfelt meditation on the personal, communal, and transformative reasons educators and students engage in academic life. Framed by themes of self-discovery, mutual support, and the power to heal and change the world, the piece underscores the spiritual and emotional dimensions of education, rooted in the values of communio and shared human connection.

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Efficient Collaboration: How To Build Pathways Between Silos, Model Behavior Ideal For Professional Identity Formation, And Create Complex Experiential Modules All While Having Fun, Christine Cerniglia Brown Apr 2015

Efficient Collaboration: How To Build Pathways Between Silos, Model Behavior Ideal For Professional Identity Formation, And Create Complex Experiential Modules All While Having Fun, Christine Cerniglia Brown

Journal of Experiential Learning

No abstract provided.

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Obesity Susceptibility Loci In Qataris, A Highly Consanguineous Arabian Population, Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane Apr 2015

Obesity Susceptibility Loci In Qataris, A Highly Consanguineous Arabian Population, Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane

NYMC Faculty Publications

OBJECTIVES: In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. METHODS: Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m(2)); 131 overweight (25 kg/m(2) ≤ BMI < 30 kg/m(2)) and 483 obese (BMI ≥ 30 kg/m(2)). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. RESULTS: Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). CONCLUSION: We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.

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Faculty Observables And Self-Reported Responsiveness To Academic Dishonesty, Robert T. Burrus, Jr., Adam T. Jones, William H. Sackley, Michael Walker Apr 2015

Faculty Observables And Self-Reported Responsiveness To Academic Dishonesty, Robert T. Burrus, Jr., Adam T. Jones, William H. Sackley, Michael Walker

Administrative Issues Journal

Prior to 2009, a mid-sized public institution in the southeast had a faculty-driven honor policy characterized by little education about the policy and no tracking of repeat offenders. An updated code, implemented in August of 2009, required that students sign an honor pledge, created a formal student honor board, and developed a process to track and hold accountable, repeat offenders. Self-reported data on faculty vigilance to detect and punish cheating is collected both prior to and after a change in the honor code at a mid-sized public institution in the southeast. We find that, at the time of the first …

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Src-Family Protein Tyrosine Kinase Phosphorylates Wnk4 And Modulates Its Inhibitory Effect On Kcnj1 (Romk), Dao-Hong Lin, Peng Yue, Orlando Yarborough, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Jesse Rinehart, Wen-Hui Wang Apr 2015

Src-Family Protein Tyrosine Kinase Phosphorylates Wnk4 And Modulates Its Inhibitory Effect On Kcnj1 (Romk), Dao-Hong Lin, Peng Yue, Orlando Yarborough, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Jesse Rinehart, Wen-Hui Wang

NYMC Faculty Publications

With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. This effect is inhibited via phosphorylation at Ser1196 by serum/glucocorticoid-induced kinase 1 (SGK1), and this inhibition is attenuated by the Src-family protein tyrosine kinase (SFK). Using Western blot and mass spectrometry, we now identify three sites in WNK4 that are phosphorylated by c-Src: Tyr(1092), Tyr(1094), and Tyr(1143), and show that both c-Src and protein tyrosine phosphatase type 1D (PTP-1D) coimmunoprecipitate with WNK4. Mutation of Tyr(1092) or Tyr(1143) to phenylalanine decreased the association of c-Src or …

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Communicating Value: Understanding Adjunct Typology, Job Satisfaction Levels, And Professional Development Interests, Lisa P. Davidson Apr 2015

Communicating Value: Understanding Adjunct Typology, Job Satisfaction Levels, And Professional Development Interests, Lisa P. Davidson

Doctor of Education (EdD)

Higher education institutions are navigating budget cuts, changing enrollment, and the need to differentiate from the competition. Reductions in government funding and budgetary constraints are prompting universities to reduce the number of full-time, tenure-track faculty and rely more heavily on adjunct faculty to meet their demand for instructors. Therefore it is important to determine the distinct needs and satisfaction levels of this faculty group in order to provide appropriate resources and development opportunities for them. This study sought to determine if adjunct faculty job satisfaction levels differ based on adjunct typology (Gappa & Leslie, 1993) or institutional affiliation, and to …

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Workers Can't Find Jobs, Jobs Can't Find Workers: Solving The Talent Paradox, Harika Rao Apr 2015

Workers Can't Find Jobs, Jobs Can't Find Workers: Solving The Talent Paradox, Harika Rao

Graduate Student Dissertations, Theses, Capstones, and Portfolios

A plethora of recent employment surveys have identified the 'talent paradox' implying the inability of the employers to find suitable workers despite the abundant availability of undergraduates reportedly due to the lack of future work skills. Against this backdrop, this study aims to illuminate the need for improving the marketability of the undergraduate students by infusing hitherto untested combination of the two interventional models, namely, Edward de Bono's Six Thinking Hats and Stephen R Covey's 7 Habits of the Highly Effective People. ' The very dynamic nature of the unemployment problem among undergraduates is of current and continuing interest not …

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The Loop (Spring 2015), Taylor University Apr 2015

The Loop (Spring 2015), Taylor University

The Loop (2012-2017)

The late Spring 2015 edition of Taylor University’s The Loop.

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Heme Biosynthesis Modulation Via Δ-Aminolevulinic Acid Administration Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Raed Alhawaj, Dhara Patel, Melissa R. Kelly, Dong Sun, Michael S. Wolin Apr 2015

Heme Biosynthesis Modulation Via Δ-Aminolevulinic Acid Administration Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Raed Alhawaj, Dhara Patel, Melissa R. Kelly, Dong Sun, Michael S. Wolin

NYMC Faculty Publications

This study examines how heme biosynthesis modulation with δ-aminolevulinic acid (ALA) potentially functions to prevent 21-day hypoxia (10% oxygen)-induced pulmonary hypertension in mice and the effects of 24-h organoid culture with bovine pulmonary arteries (BPA) with the hypoxia and pulmonary hypertension mediator endothelin-1 (ET-1), with a focus on changes in superoxide and regulation of micro-RNA 204 (miR204) expression by src kinase phosphorylation of signal transducer and activator of transcription-3 (STAT3). The treatment of mice with ALA attenuated pulmonary hypertension (assessed through echo Doppler flow of the pulmonary valve, and direct measurements of right ventricular systolic pressure and right ventricular hypertrophy), …

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Pacific Review Spring 2015, Alumni Association Of The University Of The Pacific Apr 2015

Pacific Review Spring 2015, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

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Curtailing Endothelial Tgf-Β Signaling Is Sufficient To Reduce Endothelial-Mesenchymal Transition And Fibrosis In Ckd, Sandhya Xavier, Radovan Vasko, Kei Matsumoto, Joseph A. Zullo, Robert Chen, Julien Maizel, Praveen N. Chander, Michael S. Goligorsky Apr 2015

Curtailing Endothelial Tgf-Β Signaling Is Sufficient To Reduce Endothelial-Mesenchymal Transition And Fibrosis In Ckd, Sandhya Xavier, Radovan Vasko, Kei Matsumoto, Joseph A. Zullo, Robert Chen, Julien Maizel, Praveen N. Chander, Michael S. Goligorsky

NYMC Faculty Publications

Excessive TGF-β signaling in epithelial cells, pericytes, or fibroblasts has been implicated in CKD. This list has recently been joined by endothelial cells (ECs) undergoing mesenchymal transition. Although several studies focused on the effects of ablating epithelial or fibroblast TGF-β signaling on development of fibrosis, there is a lack of information on ablating TGF-β signaling in the endothelium because this ablation causes embryonic lethality. We generated endothelium-specific heterozygous TGF-β receptor knockout (TβRII(endo+/-)) mice to explore whether curtailed TGF-β signaling significantly modifies nephrosclerosis. These mice developed normally, but showed enhanced angiogenic potential compared with TβRII(endo+/+) mice under basal conditions. After induction …

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Accuracy Of Optic Nerve Sheath Diameter Measurement By Emergency Physicians Using Bedside Ultrasound, Getaw Worku Hassen, Isaac Bruck, Joseph Donahue, Benjamin Mason, Brett Sweeney, Weafue Saab, Jeremy Weedon, Neal Patel, Kenneth Perry, Hussein Matari, Rajnish Jaiswal, Hossein Kalantari Apr 2015

Accuracy Of Optic Nerve Sheath Diameter Measurement By Emergency Physicians Using Bedside Ultrasound, Getaw Worku Hassen, Isaac Bruck, Joseph Donahue, Benjamin Mason, Brett Sweeney, Weafue Saab, Jeremy Weedon, Neal Patel, Kenneth Perry, Hussein Matari, Rajnish Jaiswal, Hossein Kalantari

NYMC Faculty Publications

BACKGROUND: Ultrasound (US) measurement of the optic nerve sheath diameter (ONSD) has been utilized as an indirect assessment of intracranial pressure. It is usually performed by trained ultrasonographers. OBJECTIVES: To evaluate whether or not emergency physicians (EP) are capable of measuring the ONSD accurately by US. MATERIALS AND METHODS: A retrospective measurement of ONSD was conducted on computed tomography (CT) scans of the head or facial bones. These patients had undergone ocular US performed by EPs prior to CT scanning. The CT scan measurements of ONSD read by a board-certified radiologist were compared with that of the US read by …

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Targeting Cd20+ Aggressive B-Cell Non-Hodgkin Lymphoma By Anti-Cd20 Car Mrna-Modified Expanded Natural Killer Cells In Vitro And In Nsg Mice, Yaya Chu, Jessica Hochberg, Ashlin Yahr, Janet Ayello, Carmella Van De Ven, Matthew Barth, Myron Czuczman, Mitchell S. Cairo Apr 2015

Targeting Cd20+ Aggressive B-Cell Non-Hodgkin Lymphoma By Anti-Cd20 Car Mrna-Modified Expanded Natural Killer Cells In Vitro And In Nsg Mice, Yaya Chu, Jessica Hochberg, Ashlin Yahr, Janet Ayello, Carmella Van De Ven, Matthew Barth, Myron Czuczman, Mitchell S. Cairo

NYMC Faculty Publications

The prognosis is very dismal for patients with relapsed CD20(+) B-cell non-Hodgkin lymphoma (B-NHL). Facilitating the development of alternative novel therapeutic strategies is required to improve outcomes in patients with recurrent/refractory CD20(+) B-NHL. In this study, we investigated functional activities of anti-CD20 CAR-modified, expanded peripheral blood NK cells (exPBNK) following mRNA nucleofection against CD20(+) B-NHL in vitro and in vivo. CAR(+) exPBNK had significantly enhanced in vitro cytotoxicity, compared with CAR(-) exPBNK against CD20(+) Ramos (P < 0.05), Daudi, Raji, and two rituximab-resistant cell lines, Raji-2R and Raji-4RH (P < 0.001). As expected, there was no significant difference against CD20(-) RS4;11 and Jurkat cells. CD107a degranulation and intracellular IFNγ production were also enhanced in CAR(+) exPBNK in response to CD20(+) B-NHL -: specific stimulation. In Raji-Luc and Raji-2R-Luc xenografted NOD/SCID/γ-chain(-/-) (NSG) mice, the luciferase signals measured in the CAR(+) exPBNK-treated group were significantly reduced, compared with the signals measured in the untreated mice and in mice treated with the CAR(-) exPBNK. Furthermore, the CAR exPBNK-treated mice had significantly extended survival time (P < 0.001) and reduced tumor size, compared with those of the untreated and the CAR(-) exPBNK-treated mice (P < 0.05). These preclinical data suggest that ex vivo-exPBNK modified with anti-CD20 CAR may have therapeutic potential for treating patients with poor-risk CD20(+) hematologic malignancies.

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Utilization Of A Real-Time Pcr Assay For Diagnosis Of Babesia Microti Infection In Clinical Practice, Guiqing Wang, Gary P. Wormser, Jian Zhuge, Patrick Villafuerte, Dawn Ip, Christine Zeren, John T. Fallon Apr 2015

Utilization Of A Real-Time Pcr Assay For Diagnosis Of Babesia Microti Infection In Clinical Practice, Guiqing Wang, Gary P. Wormser, Jian Zhuge, Patrick Villafuerte, Dawn Ip, Christine Zeren, John T. Fallon

NYMC Faculty Publications

Babesiosis is an emerging tick-borne disease mainly caused Babesia microti, a protozoan that infects erythrocytes. Microscopic examination of blood smears is the current gold standard for detection of Babesia infection, but this diagnostic test has several limitations. We developed and assessed the clinical utilization of a multiplex real-time PCR assay targeting the 18S rRNA gene of B. microti and the human gapdh gene. The limit of detection of this PCR assay was approximately 1-3parasites/μl of blood. The assay showed a diagnostic sensitivity and probable specificity of 100% based on testing 145 retrospective and 185 prospective blood specimens from controls and …

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Pass Quantity, Focus On Quality, Delong Liu, Weijing Sun, Jingzhou Hou, Ruirong Yuan, Zihai Li Mar 2015

Pass Quantity, Focus On Quality, Delong Liu, Weijing Sun, Jingzhou Hou, Ruirong Yuan, Zihai Li

NYMC Faculty Publications

Journal of Hematology & Oncology is pleased to see the exponential growth in the number of publications from China, especially in hematology and oncology. This editorial calls for putting more weight on the quality of the future scientific output and invites rigorous dialogs among policy makers, granting agencies, academic leaders, physicians, and scientists, followed by concrete actions, to achieve such a goal.

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Regulation Of Nonclassical Renin-Angiotensin System Receptor Gene Expression In The Adrenal Medulla By Acute And Repeated Immobilization Stress, Regina Nostramo, Lidia Serova, Marcela Laukova, Andrej Tillinger, Chandana Peddu, Esther L. Sabban Mar 2015

Regulation Of Nonclassical Renin-Angiotensin System Receptor Gene Expression In The Adrenal Medulla By Acute And Repeated Immobilization Stress, Regina Nostramo, Lidia Serova, Marcela Laukova, Andrej Tillinger, Chandana Peddu, Esther L. Sabban

NYMC Faculty Publications

The involvement of the nonclassical renin-angiotensin system (RAS) in the adrenomedullary response to stress is unclear. Therefore, we examined basal and immobilization stress (IMO)-triggered changes in gene expression of the classical and nonclassical RAS receptors in the rat adrenal medulla, specifically the angiotensin II type 2 (AT2) and type 4 (AT4) receptors, (pro)renin receptor [(P)RR], and Mas receptor (MasR). All RAS receptors were identified, with AT2 receptor mRNA levels being the most abundant, followed by the (P)RR, AT1A receptor, AT4 receptor, and MasR. Following a single IMO, AT2 and AT4 receptor mRNA levels decreased by 90 and 50%, respectively. Their …

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Blood Transfusion And Colorectal Cancer Outcome, Christina Jenkins, Albert B. Lowenfels Mar 2015

Blood Transfusion And Colorectal Cancer Outcome, Christina Jenkins, Albert B. Lowenfels

NYMC Faculty Publications

No abstract provided.

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