Digital Commons Network^™

Society For Healthcare Epidemiology Of America (Shea) Infectious Diseases Fellow Infection Prevention And Control And Healthcare Epidemiology Curriculum, Elise M Martin, Catherine Cichon, Rebecca Choudhury, Shandra R Day, Yasaman Fatemi, Vera P Luther, Terri Stillwell, Abby Sung

2020-Current year OA Pubs

With the rapid expansion of the Infection Prevention Control/Healthcare Epidemiology (IPC/HE) fields over recent decades, the pivotal roles of IPC/HE in hospital regulation, quality improvement, patient safety, and healthcare finances have become increasingly apparent. Consequently, the demand for effective IPC/HE leaders has surged.

Diverse Diagnostic And Management Approaches For Acute Rheumatic Fever In Australia And New Zealand: Findings Of A Prospective Clinical Study, Ruwani Peiris, Rachel Webb, Julie Bennett, Jennifer Yan, Joshua Reginald Francis, Bo Remenyi, Florina Chan Mow, Rachel Burgess, Nigel J. Wilson, Alicia Stanley, Laura Francis, Rhonda Holloway, Roxanne Westbury, Shirley Lawrence, Yolanda Hernandez-Gomez, David Broadhurst, Nicole J. Moreland, Reuben Mcgregor, Caroline Motteram, Glenn Pearson, Mark Mayo, Anna P. Ralph, Jonathan R. Carapetis

Research outputs 2022 to 2026

Objectives To describe diagnostic and management characteristics of acute rheumatic fever (ARF) among participants in the € Searching for a Technology-Driven Acute Rheumatic Fever Test' study, in order to answer clinical questions and determine epidemiological and practice differences in different settings. Design Multisite, prospective cohort study. Setting One hospital in northern Australia and two hospitals in New Zealand, 2018-2021. Participants 143 episodes of definite, probable or possible ARF among 141 participants (median age 10 years, range 5-23; 98% Indigenous). Primary and secondary outcome measures Participant characteristics, clinical, biochemical and echocardiographic data were explored using descriptive data. Associations with length of …

The Impact Of Adverse Childhood Experiences And Living With Hiv On Cardiovascular Health And Cardiometabolic Disorders In An African Population: An Analysis Of The Indepth Community In Rural South Africa, Samuel Gavi

Theses and Dissertations

Background: Adverse Childhood Experiences (ACEs) have been shown to be associated with cardiometabolic disorders (CMDs) and poor CVH; however, in Africa, this has not been well studied. Cardiovascular health (CVH) is an important measure of risk for cardiovascular diseases (CVD) developed by the American Heart Association (AHA). With the increasing prevalence of CVD in Africa, CVH is a potential upstream prevention approach. Africa also has the highest prevalence of HIV, and an increasing prevalence of comorbidities associated with it. Various mechanisms have been investigated to explain the relationship between CVD and chronic HIV infection. This study explores the potential relationship …

Bathtub Concept In Health Sciences A Comment, Nidhi Dwivedi, Sandeep Sachdeva, Anika Sulania

Indian Journal of Health Sciences and Biomedical Research KLEU

Bathtub shape has important connotations in public health and the concept could be reflected in two novel ways: (1) engineering (2) epidemiological model. Typical bath-tub curve is a combination of three failure rates, that is, decreasing, constant, and increasing failure rate, and different techniques are utilized to reduce these failures. This brief study highlights the concept of bath-tub, related theory, application, and how data modeling could be undertaken considering bath-tub failure rate.

Epidemiology Of Acute Infectious Diarrhea-Associated Viruses In Children In Hangzhou, China, 2023, Ya-Jun Guo, Lin Li, Qin-Rui Lai, Wei Li

Journal of Pediatric Infectious Diseases

Objective: To investigate the epidemiological characteristics of children infected with diarrheal virus in Hangzhou, China, 2023.

Methods: From January 2023 to December 2023, 20,939 stool samples from children with acute infectious diarrhea were collected for detection of rotavirus A and human adenovirus, using Latex agglutination detection kits; 7584 stool samples were collected for detection of norovirus, using real‐time PCR reagent.

Results: 639 (3.0%, 639/20,939) tested positive for rotavirus A, and 1,201 (5.7%, 1,201/20,939) positive samples were detected by Colloidal gold method. The positive rates of norovirus were 42.2% (3,203/7,585). Among all age groups, the rotavirus A positive detection rate was …

Adenovirus Species In U.S. Children With Acute Respiratory Illness, 2016-2019, Varvara Probst, Tess Stopczynski, Justin Z Amarin, Adam Gailani, Herdi K Rahman, Laura S Stewart, Rangaraj Selvarangan, Jennifer E Schuster, Marian G Michaels, John V Williams, Julie A Boom, Leila C Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P Schlaudecker, Christina Quigley, Christopher J Harrison, Mary E Moffatt, Geoffrey A Weinberg, Peter G Szilagyi, Janet A Englund, Eileen J Klein, Aaron T Curns, Heidi L Moline, Ariana P Toepfer, Susan I Gerber, James D Chappell, Andrew J Spieker, Natasha B Halasa

Faculty, Staff and Students Publications

Background: Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI). HAdV-B, -C, and -E species have been associated with ARI, though relative detection frequencies in United States (U.S.) and respective roles in symptomatic respiratory infections remain unclear.

Methods: We conducted a multicenter, prospective viral surveillance study at 7 U.S. children's hospitals comprising the New Vaccine Surveillance Network from January 12, 2016 to November 30, 2019. Children < 18 years old in the emergency department or hospitalized with fever and/or respiratory symptoms were enrolled, and respiratory specimens were tested for HAdV and other viral pathogens. HAdV-positive specimens were subsequently typed using single-plex real-time PCR assays targeting sequences in the hexon gene. Demographics, clinical characteristics, and outcomes (hospitalization and supplemental oxygen use as severity indicators) were compared between HAdV-B and HAdV-C species.

Results: Of the 29 381 children with ARI, 1843 (6.3%) had HAdV detected, with 1402 specimens (76.0%) successfully typed. HAdV-C was the most frequently detected species (73.0%), followed by HAdV-B …

Evaluating Impacts Of Improved Flooring On Enteric And Parasitic Infections In Rural Households In Kenya: Study Protocol For A Cluster-Randomised Controlled Trial, Katherine E. Halliday, Stella Kepha, Hugo Legge, Elizabeth Allen, Robert Dreibelbis, Lynne Elson, Beatrice K. Kakoi, Carlos Mcharo, Sharon Muli, Jacinta Mwongeli, Doris Njomo, Margaret M. Njoroge, Victoria Ochwal, William E. Oswald, Martin Rono, Tuva K. Safari, Ulrike Filinger, James Wambua Kaluli, Charles S. Mwandawiro, Rachel L. Pullan

All Peer-Reviewed Publications

Introduction Earthen floors are often damp or dusty and difficult to clean, providing an ideal environment for faecal pathogens and parasites. Observational studies have revealed associations between household flooring and health outcomes, but robust experimental evidence is scant. This study will evaluate the impact of an improved household flooring intervention on enteric infections, soil-transmitted helminth (STH) infections and tungiasis through implementation of a cluster-randomised trial in two rural settings in Kwale and Bungoma Counties, Kenya. Methods and analyses 440 clusters (households) across both sites are allocated to control or intervention group, in which a low-cost, sealed, washable, cement-based floor is …

Dermatologic Fungal Neglected Tropical Diseases-Part I Epidemiology And Clinical Features, Kaya L Curtis, Jeremy A W Gold, Jana M Ritter, Theodore Rosen, Daniel Wagner C L Santos, Dallas J Smith, Shari R Lipner

Faculty, Staff and Students Publications

In this part 1 of a 2-part continuing medical education series, the epidemiology, clinical features, and diagnostic methods for fungal skin neglected tropical diseases (NTDs), which include eumycetoma, chromoblastomycosis, paracoccidioidomycosis, sporotrichosis, emergomycosis, talaromycosis, and lobomycosis, are reviewed. These infections, several of which are officially designated as NTDs by the World Health Organization, cause substantial morbidity and stigma worldwide and are receiving increased attention due to the potential for climate change-related geographic expansion. Domestic incidence may be increasing in the setting of global travel and immunosuppression. United States dermatologists may play a central role in early detection and initiation of appropriate …

Mpox 2022 To 2025 Update: A Comprehensive Review On Its Complications, Transmission, Diagnosis, And Treatment, Rajesh Yadav, Anis Ahmad Chaudhary, Ujjwal Srivastava, Saurabh Gupta, Sarvesh Rustagi, Hassan Ahmed Rudayni, Vivek Kashyap, Sanjay Kumar

School of Medicine Publications

Monkeypox virus (Mpox virus) is a zoonotic orthopoxvirus that has gained increased global attention due to recent outbreaks. The current review reports the latest update of Mpox cases from 25 February 2022 to 29 April 2025. It also evaluates the possible major complications in human life caused by Mpox. In early 2022, more than 40 countries reported Mpox outbreaks. As of 12 June 2024, the global case count for the 2022–2023 Mpox outbreak was 97,281 confirmed cases, in 118 countries. The World Health Organization (WHO) declared the Mpox virus, a zoonotic disease, a public health emergency of international concern (PHEIC) …

Diagnostic Significance Of Neutrophil-Lymphocyte Ratio (Nlr) In Dogs With Chronic Enteropathy: A Meta-Analytical Study, Mohamed Marzok, Mahmoud Kandeel, Mohamed Tharwat, Sabry El-Khodery

The Thai Journal of Veterinary Medicine

This meta-analysis aimed to determine the diagnostic significance of the neutrophil-to-lymphocyte ratio (NLR) in dogs with chronic enteropathy (CE). This meta-analysis was constructed according to the PRISMA statement guidelines. The Web of Science, Sage, EBESCO, Ovid, Scopus, and Google Scholar databases were searched. Standardized mean difference (SMD) and odds ratio (OR) were calculated. Heterogenicity and publication bias were evaluated in this study. Five studies were found to be eligible for the assessment of the diagnostic significance of the NLR in dogs with CE. In total, 570 dogs (263 with CE and 307 healthy controls) were included in this study. NLR …

Turning Analysis Into Action: Opportunities And Challenges In Implementing Wastewater Science For Public Health Decision-Making, Anna Gitter, Valeria Ruvalcaba, Katelyn Clark, Theresa Tran Carapucci, Fuqing Wu, Blake M Hanson, Jennifer Deegan, John Balliew, Eric Boerwinkle, Anthony W Maresso, Kristina D Mena

Faculty, Staff and Students Publications

In the 5 years since the emergence of the COVID-19 pandemic, the field of wastewater-based epidemiology (WBE) has dramatically expanded with programs implemented across the globe to monitor for SARS-CoV-2 and other viruses of public health concern. However, the best way to use wastewater surveillance data and inform local communities of the utility of wastewater science remains limited and sporadically discussed. Specifically, there is vague guidance regarding interpreting varying levels of viral loads in wastewater for public health significance. While collaborative efforts are key to implementing these community-specific wastewater surveillance programs, effectively using the data for public health decision-making still …

A Review Of Trends And Contributing Factors In Tick-Borne Disease Surveillance In Maine, 2001–2024, Sara Robinson, Haris Sohail, Megan Porter

Journal of Maine Medical Center

Importance: Tick-borne diseases have a major health impact in Maine. There are 5 endemic diseases: anaplasmosis, babesiosis, hard tick relapsing fever, Lyme disease, and Powassan virus disease. Cases of these 5 diseases have increased dramatically over the past 15 years.

Objective: The objective of this review is to summarize tick-borne disease data in Maine. This summary includes showing trends and identifying factors that may be contributing to the trends.

Review: There is a long history of publications about tick-borne diseases in Maine, with articles first appearing in the 1980s. We analyzed tick-borne disease surveillance data collected by Maine Center for …

Tick-Borne Diseases: New Territory, New Agents, Robert Smith, Sam R. Telford Iii

Journal of Maine Medical Center

Importance: The incidence of tick-borne diseases is on the rise across North America as the ranges of tick vectors, such as the blacklegged or deer tick and the lone star tick, expand. In addition, 8 new agents of human tick-borne disease have been discovered in North America in the past few decades.

Objective: Our objective is to provide a current overview of tick-borne diseases, including recently described pathogens, in North America for public health professionals, researchers, and clinicians. Our focus is on the importance of regional epidemiology and the clinical spectrum of tick-borne diseases to increase their recognition.

Review: …

Epidemiological And Clinical Characteristics Of Children With Measles In Babil Governorate In 2024, Hasan Alwan Baiee, Zainab Hamed Abdel Qader, Zahraa Hossam Abdul Hussein, Ali Mohsen Flih

Hilla University College Journal For Medical Science

Background: Measles considered a highly contagious and serious disease affecting mainly children in their early years, with morbidity and mortality. The effective preventive measure against measles is vaccination.

Objective: To identify the epidemiological characteristics of patients with measles admitted to Maternity and Children’s Teaching Hospital in Babylon Governorate.

Materials and Methods: A hospital-based cross-sectional study was conducted using structured questionnaire on convenient sample of children infected with the measles virus and hospitalized in Maternity and Children’s Teaching Hospital, Babylon Governorate, Iraq. During three-monthperiod from the first of January to 30^th of March, 2024. A special semi-structured validated and reliable …

Covid-19 And Related Adverse Neurological Complications, Hannah A. Wasson

Honors Thesis

Abstract

The COVID-19 pandemic changed the world drastically, and its impact was monumental. COVID-19 or SARS-CoV-2, or severe acute respiratory syndrome, was the virus responsible for causing such mayhem. This contagious virus can enter the body via different routes, live on surfaces for hours, and be transmitted through the air, increasing infection risk. Once it enters the body, it can trick the body into replicating the virus. From this reaction within the body, signs and symptoms follow. While the name indicates a respiratory illness, the virus can inflict injury on other parts of the body. Due to the organ systems …

A Modified Sir Model Used To Investigate The Relationship Between Congenital And Adult Syphilis, Kaleesta R. Waysman

Honors Thesis

A complex SIR model integrating the relationship between adult and congenital syphilis was developed. The goal of the project was to determine the specific population(s) or control strategies that should be enforced, altered, or removed to decrease the number of children experiencing clinical sequelae due to congenital syphilis. Early clinical sequelae include hydrops fetalis, preterm birth, central nervous system infection, hepatosplenomegaly, hyperbilirubinemia, cholestasis, hemolytic anemia, snuffles, osteochondritis, and lesions or rashes in the palms and soles. Late clinical sequelae include interstitial keratitis, hearing loss, Hutchinson teeth, saber shins, Clutton joints, mulberry molars, and saddle nose. After implementing real-world data into …

Covid-19 Infection History As A Risk Factor For Early Pregnancy Loss: Results From The Electronic Health Record-Based Southeast Texas Covid And Pregnancy Cohort Study, Micaela N Sandoval, Michelle R Klawans, Mackinsey A Bach, Jennifer Mikhail, Edward A Graviss, Tru Cao, Jacqueline G Parchem, Junaid Husain, Eric Boerwinkle

Faculty, Staff and Student Publications

Background: The effects of SARS-CoV-2 infection before or during pregnancy on pregnancy outcomes are still largely unknown. We hypothesized that COVID-19 in early pregnancy is a risk factor for adverse pregnancy outcomes, particularly miscarriage.

Methods: We examined the relationship between COVID-19 and adverse pregnancy outcomes, including spontaneous abortion, ectopic pregnancy, and preterm delivery in a large, retrospective, electronic health record (EHR)-based cohort, from 2019 to 2023. Generalized estimating equation modeling was performed to identify risk factors for adverse pregnancy outcomes. Study exposures included COVID-19 before pregnancy, COVID-19 during pregnancy, age, race/ethnicity, comorbidity burden, and neighborhood-level social vulnerability.

Results: In the …

Demography Of Bluff View Cemetery Vermillion, Sd, Ellie E. Schwartz

Honors Thesis

Cemeteries offer accessible, rich data for research on demographic reconstruction of past populations. Gravestones can give vital information such as date of birth, date of death, sex/gender, occupation, religious affiliation, and, implicitly, social and cultural values of the community at large (Dethlefsen and Deetz, 1966; Sattenspiel and Stoops, 2010). One of the drawbacks of cemetery data are that they more often than not do not provide details of the cause of death for an individual or in some rare occasions cause of death is on the gravestones (e.g., colonial graves during the tuberculosis outbreak in New England would often list …

Death Becomes Us: The Consumptive Body In Nineteenth-Century Gothic Literature, Jennifer Marie Mcmahon

All NMU Master's Theses

This thesis examines the impacts of nineteenth-century tuberculosis epidemics on gothic literature published between 1842 and 1872. In this period of time, tuberculosis was the leading cause of death in the United States and in Europe, killing an estimated one in seven people. Using theoretical lenses of psychoanalysis and material ecocriticism, this project considers borders between material bodies—specifically those between bacterial agents and humans—to be illusory and socially constructed. The first chapter focuses on the ways in which representations of tuberculosis, and its associated entanglement with the environment, appear in the work of two authors from the United States: Edgar …

Scaling Covid-19 Rates With Population Size In The United States, Austin R. Cruz, Brian J. Enquist, Joseph R. Burger

Biology Faculty Publications

Using county-level data from the United States, we assessed allometric scaling relationships of coronavirus disease (COVID-19) cases, deaths and age structure within and across the first four major waves of the pandemic (wild-type, alpha, delta, omicron). Results generally indicate that the burden of cases disproportionately impacted larger-sized counties, while the burden of deaths disproportionately impacted smaller counties. This may be partially due to multiple interacting social mechanisms, including a higher proportion of older adults who live in smaller counties. Moreover, these likely social mechanisms interacting with vaccinations and virus waves created a dynamic pattern whereby the rate and magnitude of …

Systematic Evaluation Of Regression Models For The Prediction Of Influenza Cases, Mukul Kandwal

Theses

This study systematically evaluates machine learning models to forecast influenza outbreaks, aiming to enhance public health preparedness through accurate predictions. Laboratory-confirmed influenza case data from the New York State Department of Health (2009–2023) were used to train and test five regression models—XGBoost, Neural Network (MLP regressor), K-Nearest Neighbors (KNN), Random Forest, and Support Vector Regression (SVR)—with preprocessing techniques including differencing and phasing. A leave-one-season-out cross-validation framework and Symmetric Mean Absolute Percentage Error (SMAPE) were employed to rigorously assess performance. Key findings reveal that the Neural Network (MLP regressor) outperformed other models, achieving the lowest SMAPE score (23.7), underscoring the critical …

Resurgence Of Pediatric Mycoplasma Pneumoniae Infections In Southeast Texas, November 2023-June 2024, Margaret Taylor Danner, Heather Colvin Binns, Khanh Nguyen, Coreen Johnson, Jim Dunn, Denver Niles, Diana K Nguyen

Faculty, Staff and Students Publications

We conducted a retrospective review of children tested for Mycoplasma pneumoniae from January 1, 2020 to June 30, 2024. M. pneumoniae polymerase chain reaction positivity increased starting in November 2023, peaking at 18.3% in June 2024. During the resurgence, children with laboratory-confirmed infection often had severe respiratory disease or extrapulmonary manifestations.

Climate Change Will Impact Childhood Cancer Risks, Care And Outcomes., Hannah M. Thompson, Perry Sheffield, Omar Shakeel, Nicole Wood, Mark D. Miller

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

A Case Study In Program Evaluation, Kaitlyn E. Lee

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

This capstone project evaluates a fictious online MRSA education program developed by the Lexington-Fayette County Health Department and Fayette County Public Schools after a suspected outbreak among student athletes. Using the CDC’s 6-Step Framework for Program Evaluation, the project focuses on how stakeholders were engaged, how the program was described and mapped, how the evaluation questions were developed, what evidence was collected, and how conclusions were formed. The goal of the evaluation is to understand whether the program’s structure, delivery, and implementation support clear infection-control education for the different school personnel who use it. This project emphasizes the overall evaluation …

A Mathematical Modeling Approach To Investigate The Impacts Of Post-Infection Mortality And Partial Immunity On Disease Endemicity, Brendan M. Shrader

Honors Undergraduate Theses

A number of infectious diseases cause post-infection conditions or complications, such as COVID- 19, Q fever, and Polio. These conditions result in recovered individuals having a higher mortality rate than susceptibles, and this can impact disease dynamics. An existing mass-action model in the literature that incorporated post-infection mortality was shown to have limit cycles, or persistent oscillations, in the infected population. To better understand what causes these limit cycles, we develop and analyze a new epidemiological model with standard incidence. We show standard results, including the existence, uniqueness, and stability of the disease-free and endemic equilibria, and we rule out …

Long Covid Risk Factors And Outcomes Among Solid Organ Transplant Recipients: A Retrospective Cohort Study, Micaela N Sandoval, Linda W Moore, Howard J Huang, Edward A Graviss

Faculty, Staff and Student Publications

Background: Solid organ transplant (SOT) recipients are not only at increased risk of morbidity and mortality due to acute COVID-19 but may also experience poor long-term outcomes due to post-acute COVID-19 syndromes, including long COVID.

Methods: This retrospective, registry-based chart review evaluated graft failure and mortality among SOT recipients diagnosed with COVID-19 at a large, urban transplant center in Houston, Texas, USA. Patient populations were analyzed separately according to their long COVID status at the time of transplant to preserve the temporal relationship between the exposure (long COVID) and the outcome (graft failure or mortality).

Results: In total, 146 (5%, …

Smoking Habit And Long-Term Colorectal Cancer Incidence By Exome-Wide Mutational And Neoantigen Loads: Evidence Based On The Prospective Cohort Incident-Tumour Biobank Method, Tsuyoshi Hamada, Tomotaka Ugai, Carino Gurjao, Satoko Ugai, Xuehong Zhang, Koichiro Haruki, Yasutoshi Takashima, Naohiko Akimoto, Mai Chan Lau, Kosuke Matsuda, Nobuhiro Nakazawa, Mayu Higashioka, Satoshi Miyahara, Keisuke Kosumi, Yohei Masugi, Li Liu, Yin Cao, Daniel Nevo, Molin Wang, Reiko Nishihara, Sachet A Shukla, Catherine J Wu, Levi A Garraway, Jeffrey A Meyerhardt, Edward L Giovannucci, Jonathan A Nowak, Charles S Fuchs, Andrew T Chan, Mingyang Song, Marios Giannakis, Shuji Ogino

Faculty, Staff and Student Publications

Objective: To test the hypothesis that the association of smoking with long-term colorectal cancer incidence may be stronger for tumours with higher mutational and neoantigen loads.

Methods and analysis: In the Nurses' Health Study (1980-2012) and the Health Professionals Follow-up Study (1986-2012), our novel prospective cohort incident-tumour biobank method (PCIBM) used 3053 incident colorectal carcinoma cases including 752 cases with whole-exome sequencing data. Using the multivariable duplication-method Cox regression model with the inverse probability weighting to adjust for the selection bias due to tissue availability, we assessed a differential association of cigarette smoking with colorectal carcinoma incidence by an exome-wide …

Mathematical Modelling And Analysis For The Co-Infection Of Viral And Bacterial Diseases: A Systematic Review Protocol, Timothy Kiprono Yano, Ebenezer Afrifa-Yamoah, Julia Collins, Ute Mueller, Steven Richardson

Research outputs 2022 to 2026

Introduction Breaking the chain of transmission of an infectious disease pathogen is a major public health priority. The challenges of understanding, describing and predicting the transmission dynamics of infections have led to a wide range of mathematical, statistical and biological research problems. Advances in diagnostic laboratory procedures with the ability to test multiple pathogens simultaneously mean that co-infections are increasingly being detected, yet little is known about the impact of co-infections in shaping the course of an infection, infectivity, and pathogen replication rate. This is particularly true of the apparent synergistic effects of viral and bacterial co-infections, which present the …

Prospective, Crossover, Comparative Study Of Two Methods Of Chlorhexidine Bathing, Richard J. Hankins

Theses & Dissertations

Bathing intensive care unit (ICU) patients with chlorhexidine gluconate (CHG) decreases hospital acquired infections (HAIs). The optimal method of CHG bathing remains undefined. Prospective cluster crossover study comparing CHG daily bathing with 2% CHG impregnated cloths versus 4% CHG solution. In phase 1, from January 2020 through March 2020, one ICU utilized 2% cloths, while the other ICU utilized 4% solution. After an interruption caused by the COVID-19 pandemic, in phase 2, from July 2020 through September 2020, the unit CHG bathing assignments were reversed. Swabs were performed three times per week from patients’ arms and legs to measure skin …

Mathematical Modelling Of Disease Outbreak, Favour Christian, Matthew Molloy

SURE Journal: Science Undergraduate Research Experience Journal

Establishing a model framework for more research necessitates a thorough understanding of the causes, distribution, prevalence, and evolution of infectious illnesses. The main mathematical concept used in this modelling simulation is ordinary differential equations (ODEs). The purpose of this study was to investigate the significance of the many criteria linked to a zombie virus spread. The zombie framework provides an accessible and relatively simple representation of the nature of infectious disease spread, allowing for tractable assumptions and the development of more complex situations.

The models are designed around a zombie outbreak in which the zombie virus is spread through a …