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Diet Modification Reduces Pain And Improves Function In Adults With Osteoarthritis: A Systematic Review, Karen Stanfar, Corey Hawes, Mina Ghajar, Laura Byham-Gray, Diane R. Radler Aug 2024

Diet Modification Reduces Pain And Improves Function In Adults With Osteoarthritis: A Systematic Review, Karen Stanfar, Corey Hawes, Mina Ghajar, Laura Byham-Gray, Diane R. Radler

Health & Biomedical Sciences Faculty Publications

Background

The effect of dietary modifications on pain and joint function in adults with osteoarthritis (OA) is an emerging area of study. This systematic review aimed to evaluate if adults with OA who consume diets with a higher proportion of plant phenols and omega-3 fatty acids would have less pain and improved joint function than those with a higher proportion of saturated fatty acids, omega-6 fatty acids and refined carbohydrates.

Methods

Database searches of CINAHL (EBSCO), Clinical Trials (NIH-NLM), Cochrane Library (Wiley), Dissertation & Thesis Global (ProQuest), Embase (Elsevier), Medline (OVID), PubMed (NLM), Scopus (Elsevier), Web of Sciences (Clarivate) for …


Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, And Cardiovascular Disease Risk In Us Hispanics And Latinos: Results From Hchs/Sol, Yi Wang, Guo-Chong Chen, Zheng Wang, Kai Luo, Yanbo Zhang, Yang Li, Amanda C Mcclain, Marta M Jankowska, Krista M Perreira, Josiemer Mattei, Carmen R Isasi, Maria M Llabre, Bharat Thyagarajan, Martha L Daviglus, Linda Van Horn, David Goldsztajn Farelo, Luis E Maldonado, Steven R Levine, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D Burk, Robert C Kaplan, Qibin Qi, Brandilyn A Peters Jul 2024

Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, And Cardiovascular Disease Risk In Us Hispanics And Latinos: Results From Hchs/Sol, Yi Wang, Guo-Chong Chen, Zheng Wang, Kai Luo, Yanbo Zhang, Yang Li, Amanda C Mcclain, Marta M Jankowska, Krista M Perreira, Josiemer Mattei, Carmen R Isasi, Maria M Llabre, Bharat Thyagarajan, Martha L Daviglus, Linda Van Horn, David Goldsztajn Farelo, Luis E Maldonado, Steven R Levine, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D Burk, Robert C Kaplan, Qibin Qi, Brandilyn A Peters

Faculty, Staff and Student Publications

Background: Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, and blood metabolites among US Hispanic and Latino adults.

Methods: In the HCHS/SOL (Hispanic Community Health Study/Study of Latinos), US exposure was defined by years in the United States (50 states and Washington, DC) and US nativity. A dietary acculturation pattern was derived from 14 172 participants with two 24-hour dietary recalls at baseline (2008-2011) using least absolute shrinkage and selection operator regression, with food groups as predictors of US …


Gender Effect On Torque And Explosive Characteristics At Knee Extensor In Triathletes With High And Low Eating Attitudes, Xin-Cen Wen, Wei-Chun Hsu, Li-Xin Tang, Ting-En Li, Jo-Yu Chung, Yi-Jia Lin Jul 2024

Gender Effect On Torque And Explosive Characteristics At Knee Extensor In Triathletes With High And Low Eating Attitudes, Xin-Cen Wen, Wei-Chun Hsu, Li-Xin Tang, Ting-En Li, Jo-Yu Chung, Yi-Jia Lin

ISBS Proceedings Archive

This study examined the impact of eating attitudes on the strength, agility, explosiveness, and endurance performance of 26 triathletes who were categorized into EAT-Better and EAT-Worse groups. Isometric knee extensor maximal voluntary contractions were conducted before and after cycling incremental VO2 max tests. Results showed that there were no significant between-group differences at baseline and there were gender differences in Peak Knee Extensor Joint Torque and Knee Extensor Joint Impulse. At fatigue status, only females exhibited a decrease in fatigue-induced Knee Joint Impulse. Although there were no significant between-group differences in fatigue status, EAT-Worse exhibited a more notable decrease than …


Community-Based Participatory Obesity Prevention Interventions In Rural Communities: A Scoping Review, Saagar Dhanjani, Haley Allen, Beatriz Varman, Chishinga Callender, Jayna M Dave, Debbe Thompson Jul 2024

Community-Based Participatory Obesity Prevention Interventions In Rural Communities: A Scoping Review, Saagar Dhanjani, Haley Allen, Beatriz Varman, Chishinga Callender, Jayna M Dave, Debbe Thompson

Library Staff Publications

Child obesity is a worldwide public health concern. In America, children from rural areas have greater odds of obesity in comparison to those from urban areas. Community-engaged research is important for all communities, particularly under-represented communities. This paper reports the results of a scoping review investigating community-engaged research in obesity prevention programs tested with school-aged children in rural America. A literature search of Medline Ovid was conducted to identify interventions reporting the results of obesity prevention interventions that promoted a healthy diet or physical activity (PA) behaviors to school-age children in rural communities of the United States (US). After title …


Predicting Nutrition And Environmental Factors Associated With Female Reproductive Disorders Using A Knowledge Graph And Random Forests., Lauren E Chan, Elena Casiraghi, Justin Reese, Quaker E Harmon, Kevin Schaper, Harshad Hegde, Giorgio Valentini, Charles Schmitt, Alison Motsinger-Reif, Janet E Hall, Christopher J Mungall, Peter N Robinson, Melissa A Haendel Jul 2024

Predicting Nutrition And Environmental Factors Associated With Female Reproductive Disorders Using A Knowledge Graph And Random Forests., Lauren E Chan, Elena Casiraghi, Justin Reese, Quaker E Harmon, Kevin Schaper, Harshad Hegde, Giorgio Valentini, Charles Schmitt, Alison Motsinger-Reif, Janet E Hall, Christopher J Mungall, Peter N Robinson, Melissa A Haendel

Faculty Research 2024

OBJECTIVE: Female reproductive disorders (FRDs) are common health conditions that may present with significant symptoms. Diet and environment are potential areas for FRD interventions. We utilized a knowledge graph (KG) method to predict factors associated with common FRDs (for example, endometriosis, ovarian cyst, and uterine fibroids).

MATERIALS AND METHODS: We harmonized survey data from the Personalized Environment and Genes Study (PEGS) on internal and external environmental exposures and health conditions with biomedical ontology content. We merged the harmonized data and ontologies with supplemental nutrient and agricultural chemical data to create a KG. We analyzed the KG by embedding edges and …


Exercise And Diet Support In Breast And Prostate Cancer Survivors: Findings From Focus Groups, Jack Dalla Via, Christopher R. Andrew, Brenton J. Baguley, Nina Stewart, Jonathan M. Hodgson, Joshua R. Lewis, Mandy Stanley, Mary A. Kennedy Jul 2024

Exercise And Diet Support In Breast And Prostate Cancer Survivors: Findings From Focus Groups, Jack Dalla Via, Christopher R. Andrew, Brenton J. Baguley, Nina Stewart, Jonathan M. Hodgson, Joshua R. Lewis, Mandy Stanley, Mary A. Kennedy

Research outputs 2022 to 2026

Purpose: Cancer survival is improving, making optimal management of long-term treatment-related adverse effects increasingly important. Exercise and a healthy diet are beneficial and regularly recommended in cancer survivorship guidelines; however, few cancer survivors meet these recommendations so there is a need to explore why. This study aimed to understand experiences receiving exercise and diet support among Australian breast and prostate cancer survivors during and following treatment, and to explore what support they would like to receive. Methods: Adults who completed active treatment for breast or prostate cancer were recruited via a private cancer care centre. Using a qualitative descriptive study …


The Relationship Between Diet, Depression, And Alzheimer's Disease: A Narrative Review, Hilal Salim Said Al Shamsi, Stephanie R. Rainey-Smith, Samantha L. Gardener, Hamid R. Sohrabi, Rodrigo Canovas, Ralph N. Martins, Warnakulasuriya Mary Ann Dipika Binosha Fernando Jul 2024

The Relationship Between Diet, Depression, And Alzheimer's Disease: A Narrative Review, Hilal Salim Said Al Shamsi, Stephanie R. Rainey-Smith, Samantha L. Gardener, Hamid R. Sohrabi, Rodrigo Canovas, Ralph N. Martins, Warnakulasuriya Mary Ann Dipika Binosha Fernando

Research outputs 2022 to 2026

Purpose of Review: This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings: AD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, …


Increasing The Efficiency Of Lifestyle Medicine Counseling: A Visual Approach, Kayla A. Hinton, Ryan Smith Jun 2024

Increasing The Efficiency Of Lifestyle Medicine Counseling: A Visual Approach, Kayla A. Hinton, Ryan Smith

HCA Healthcare Journal of Medicine

Too much to counsel on, too little time? We would like to present a unique and innovative perspective on lifestyle medicine counseling through the lens of a homemade flyer, designed to bridge the gap between conventional health care practices and personalized, holistic well-being. In the promising field of health care humanities, the homemade lifestyle medicine flyer serves as a tangible manifestation of individual agency in promoting health and vitality. The flyer encapsulates a diverse range of self-care practices, dietary insights, and mindfulness techniques, emphasizing the inherent connection between mind, body, and spirit in one’s health journey.

This double-sided document highlights …


Mediterranean Diet Information On Tiktok And Implications For Digital Health Promotion Research: Social Media Content Analysis, Margaret Raber, Haley Allen, Sophia Huang, Maria Vazquez, Echo Warner, Debbe Thompson Jun 2024

Mediterranean Diet Information On Tiktok And Implications For Digital Health Promotion Research: Social Media Content Analysis, Margaret Raber, Haley Allen, Sophia Huang, Maria Vazquez, Echo Warner, Debbe Thompson

Children’s Nutrition Research Center Staff Publications

Background: The Mediterranean diet has been linked to reduced risk for several cardiometabolic diseases. The lack of a clear definition of the Mediterranean diet in the scientific literature and the documented proliferation of nutrition misinformation on the internet suggest the potential for confusion among consumers seeking web-based Mediterranean diet information.

Objective: We conducted a social media content analysis of information about the Mediterranean diet on the influential social media platform, TikTok, to examine public discourse about the diet and identify potential areas of misinformation. We then analyzed these findings in the context of health promotion to identify potential challenges and …


Self-Care For Healthcare Professionals, Purnima Hernandez Dda, Ms, Ma, Chwc Jun 2024

Self-Care For Healthcare Professionals, Purnima Hernandez Dda, Ms, Ma, Chwc

Metro Denver Dental Society Articulator Magazine

This personal narrative chronicles the author's journey to prioritize self-care and adopt a lifestyle medicine approach after experiencing unexplained at the peak of her career. Realizing that succeeding in a profession dedicated to helping others required first helping herself, she immersed herself in learning about diet and lifestyle changes. By making reasonable adjustments to her sleep, nutrition, stress management, movement, and relationships, her health drastically improved within months. The article emphasizes the importance of self-care for healthcare professionals to avoid burnout and chronic lifestyle diseases. It provides a framework for developing a personalized lifestyle plan. Ultimately, the piece is a …


Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier Jun 2024

Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier

Division of Basic Science Faculty Publications

Aim: Type 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka ‘chow’) diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice. Methods: Female NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group. Results: NOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had …


Nature Of The Evidence Base And Approaches To Guide Nutrition Interventions For Individuals: A Position Paper From The Academy Of Nutrition Sciences, Mary Hickson, Constantina Papoutsakis, Angela M Madden, Mary Anne Smith, Kevin Whelan May 2024

Nature Of The Evidence Base And Approaches To Guide Nutrition Interventions For Individuals: A Position Paper From The Academy Of Nutrition Sciences, Mary Hickson, Constantina Papoutsakis, Angela M Madden, Mary Anne Smith, Kevin Whelan

Faculty, Staff and Student Publications

This Position Paper from the Academy of Nutrition Sciences is the third in a series which describe the nature of the scientific evidence and frameworks that underpin nutrition recommendations for health. This paper focuses on evidence which guides the application of dietary recommendations for individuals. In some situations, modified nutrient intake becomes essential to prevent deficiency, optimise development and health, or manage symptoms and disease progression. Disease and its treatment can also affect taste, appetite and ability to access and prepare foods, with associated financial impacts. Therefore, the practice of nutrition and dietetics must integrate and apply the sciences of …


Therapeutic Strategies Against Metabolic Imbalance In A Male Mouse Model With 5-Ht2cr Loss-Of-Function, Hailan Liu, Zhaoxun Liu, Hueyxian Kelly Wong, Nathan Xu, Qingzhuo Liu, Yongxiang Li, Yao Liu, Hueyzhong Wong, Megan E Burt, Sanika V Jossy, Junying Han, Yang He May 2024

Therapeutic Strategies Against Metabolic Imbalance In A Male Mouse Model With 5-Ht2cr Loss-Of-Function, Hailan Liu, Zhaoxun Liu, Hueyxian Kelly Wong, Nathan Xu, Qingzhuo Liu, Yongxiang Li, Yao Liu, Hueyzhong Wong, Megan E Burt, Sanika V Jossy, Junying Han, Yang He

Faculty, Staff and Students Publications

The serotonin 2C receptor (5-HT2CR)-melanocortin pathway plays well-established roles in the regulation of feeding behavior and body weight homeostasis. Dysfunctions in this system, such as loss-of-function mutations in the Htr2c gene, can lead to hyperphagia and obesity. In this study, we aimed to investigate the potential therapeutic strategies for ameliorating hyperphagia, hyperglycemia, and obesity associated with a loss-of-function mutation in the Htr2c gene (Htr2cF327L/Y). We demonstrated that reexpressing functional 5-HT2CR solely in hypothalamic pro-opiomelanocortin (POMC) neurons is sufficient to reduce food intake and body weight in Htr2cF327L/Y mice subjected to a high-fat diet (HFD). In addition, 5-HT2CR expression restores the …


Changes In Benthic Prey Availability And Quality Suggest Less Favorable Foraging Conditions For Threatened Steller's Eiders (Polysticta Stelleri) Molting At Izembek Lagoon, Alaska, Anastasia M. Maliguine May 2024

Changes In Benthic Prey Availability And Quality Suggest Less Favorable Foraging Conditions For Threatened Steller's Eiders (Polysticta Stelleri) Molting At Izembek Lagoon, Alaska, Anastasia M. Maliguine

Biological Sciences

Izembek Lagoon, located in the Alaskan southern Bering Sea, is designated as critical molting and wintering habitat for the Alaska-breeding population of Steller's eiders (Polysticta stelleri), listed as Threatened under the United States Endangered Species Act. During the nonbreeding season, the lagoon also hosts a large proportion of the Pacific population of Steller's eiders that nest along the coast of northeastern Russia, and the lagoon is an important stopover site for many other species of migratory water birds. Since the early 1980s, there has been a decline of Steller's eiders in their known nonbreeding range in the southern Bering Sea, …


Nutrition, Obesity, And Seborrheic Dermatitis: Systematic Review, Emily Woolhiser, Noah Keime, Arya Patel, Isaac Weber, Madeline Adelman, Robert P. Dellavalle May 2024

Nutrition, Obesity, And Seborrheic Dermatitis: Systematic Review, Emily Woolhiser, Noah Keime, Arya Patel, Isaac Weber, Madeline Adelman, Robert P. Dellavalle

Student Publications

Background:

Pathogenesis of seborrheic dermatitis involves lipid secretion by sebaceous glands, Malassezia colonization, and an inflammatory response with skin barrier disruption. Each of these pathways could be modulated by diet, obesity, and nutritional supplements. Current treatment options provide only temporary control of the condition; thus, it is essential to recognize modifiable lifestyle factors that may play a role in determining disease severity.

Objective:

This study aimed to summarize published evidence on diet, nutritional supplements, alcohol, obesity, and micronutrients in patients with seborrheic dermatitis and to provide useful insights into areas of further research.

Methods:

A literature search of Scopus, PubMed, …


Microbial Dysbiosis And Nutritional Factors That Promote Remyelination In Multiple Sclerosis, Katherine C. Grant, Francis Jenney May 2024

Microbial Dysbiosis And Nutritional Factors That Promote Remyelination In Multiple Sclerosis, Katherine C. Grant, Francis Jenney

Research Day

Multiple Sclerosis (MS) is an autoimmune disease characterized by the infiltration of peripheral lymphocytes into the central nervous system, resulting in inflammation and demyelination. Microbial dysbiosis has been observed in MS patients and may play a role in the loss of immune tolerance, leading to autoimmunity. Thus, it is believed that the gut microbiota can influence the inflammation seen in MS patients through the gut-brain axis. Diet and nutrition are highly implicated in inflammatory diseases because they can control the abundance of bacterial species and transcription factors and gene expression in host cells, ultimately creating pro-inflammatory or anti-inflammatory immune responses. …


Barriers And Facilitators To Adherence To Behavioral Weight Loss Interventions Among Hispanic/Latina Women, Catalina R. Pacheco May 2024

Barriers And Facilitators To Adherence To Behavioral Weight Loss Interventions Among Hispanic/Latina Women, Catalina R. Pacheco

Psychology ETDs

Behavioral weight loss (BWL) interventions can help combat obesity and related diseases, but rates of adherence are often low among Hispanic/Latina women. This study explored barriers and facilitators to adherence among this population. Fourteen women attended focus groups and were asked to identify barriers and facilitators to self-monitoring of food and exercise (SM). They additionally were asked to identify body image-related barriers and facilitators to adherence to meeting diet and exercise goals. Transcripts were analyzed using thematic analysis. Major suggestions relevant to SM were to intervene on multiple levels (i.e., community, group, individual), incorporate mental healthcare, reduce the burden of …


Stay On Track: A Pilot Randomized Control Trial On The Feasibility Of A Diet And Exercise Intervention In Patients With Breast Cancer Receiving Radiotherapy, Gopika Senthilkumar, Aronne M Schottstaedt, Lindsay L Peterson, Lauren N Pedersen, Christopher R Chitambar, Alexis Vistocky, Anjishnu Banerjee, John M Longo, Tracy Kelly, Adam Currey, Melinda R Stolley, Carmen Bergom May 2024

Stay On Track: A Pilot Randomized Control Trial On The Feasibility Of A Diet And Exercise Intervention In Patients With Breast Cancer Receiving Radiotherapy, Gopika Senthilkumar, Aronne M Schottstaedt, Lindsay L Peterson, Lauren N Pedersen, Christopher R Chitambar, Alexis Vistocky, Anjishnu Banerjee, John M Longo, Tracy Kelly, Adam Currey, Melinda R Stolley, Carmen Bergom

2020-Current year OA Pubs

PURPOSE: Among patients with breast cancer undergoing radiotherapy, posttreatment cardiovascular disease and worsened quality of life (QoL) are leading causes of morbidity and mortality. To overcome these negative radiotherapy effects, this prospective, randomized clinical trial pilots a 12-week Stay on Track exercise and diet intervention for overweight patients with nonmetastatic breast cancer undergoing whole-breast radiotherapy.

EXPERIMENTAL DESIGN: The intervention group (n = 22) participated in three personal exercise and dietary counseling sessions, and received three text reminders/week to adhere to recommendations. The control group (n = 22) was administered a diet/exercise information binder. All patients received a Fitbit, and at …


Healthier Together: A Holistic Office Protocol Addressing The Chronic Nature Of Children And Adolescents With Adhd, Kimberly Olmos May 2024

Healthier Together: A Holistic Office Protocol Addressing The Chronic Nature Of Children And Adolescents With Adhd, Kimberly Olmos

Evidence-Based Practice Project Reports

Attention Deficit Hyperactivity Disorder (ADHD) is a highly prevalent, chronic condition with symptoms that include inattention, hyperactivity, and impulsivity. ADHD affects six million children in the United States (Tran et al., 2021). The purpose of this evidence-based practice project was to implement a holistic office protocol that addressed the chronicity and future health outcomes of children and adolescents, ages 2-17 years with ADHD through stimulant or non-stimulant medication prescriptions, behavioral therapy referrals, and education surrounding diet, and exercise. A comprehensive, systematic literature search yielded 16 articles to determine best practice when treating children and adolescents with ADHD in primary or …


Relationship Between Gut Microbiota And Dementia, Saad Ahmed, Zack Harris, Russell David Levi May 2024

Relationship Between Gut Microbiota And Dementia, Saad Ahmed, Zack Harris, Russell David Levi

Rowan-Virtua Research Day

This paper explores the complex relationship between gut microbiota, dietary habits, and dementia, focusing particularly on Alzheimer's disease (AD). Growing evidence suggests a significant link between the composition of gut bacteria, dietary choices, and susceptibility to dementia. Notably, individuals with dementia demonstrate a noticeable reduction in gut bacteria diversity, highlighting the crucial role of a balanced microbiome in maintaining cognitive health. Conversely, dietary preferences characterized by excessive consumption of processed foods and sugars are associated with an increased risk of dementia, emphasizing the critical influence of diet on shaping gut microbiota and subsequent neurocognitive outcomes. Importantly, dietary interventions featuring a …


Exploration Of Resources Women Use To Seek Food And Nutrition Information During Pregnancy, Sydni Hebert May 2024

Exploration Of Resources Women Use To Seek Food And Nutrition Information During Pregnancy, Sydni Hebert

Theses, Dissertations and Culminating Projects

Nutrition is a common concern during pregnancy, yet women often do not meet the recommended nutrient intakes for a healthy pregnancy. Obtaining reliable food and nutrition information is challenging during pregnancy, and women do not know where to find credible information. AIMS: This study aims to investigate the food and nutrition information-seeking behaviors among low-income pregnant women experiencing their first pregnancy and compare these behaviors with pregnant women who are classified as middle and higher-income status. METHODS: A qualitative survey was developed to identify the type of information women seek, satisfaction with information, application of information to their diet choices, …


Fueling Performance: Tailored Nutrition Strategies For Female Athletes, Capri Pezzella May 2024

Fueling Performance: Tailored Nutrition Strategies For Female Athletes, Capri Pezzella

Capstone Projects and Master's Theses

This project aims to explore the unique nutritional considerations for female athletes, with a focus on optimizing performance and addressing specific physiological needs. Through comprehensive research, the project will identify strategies for optimizing iron intake to prevent anemia, managing calcium and vitamin D for bone health, and addressing menstrual cycle-related changes in energy expenditure and nutrient needs. Practical recommendations will be made to help female athletes maximize their potential and support their overall health.


Impact Of Obesity And Age On Mouse Corneal Innervation At The Epithelial-Stromal Interface, Justin A Courson, Rolando E Rumbaut, Alan R Burns May 2024

Impact Of Obesity And Age On Mouse Corneal Innervation At The Epithelial-Stromal Interface, Justin A Courson, Rolando E Rumbaut, Alan R Burns

Faculty, Staff and Students Publications

PURPOSE: The corneal epithelium is the most highly innervated structure in the body. Previously, we reported a novel event whereby stromal axons fuse with basal epithelial cells, limiting nerve penetration into the epithelium. Although corneal-epithelial nerves undergo changes in sensitivity and distribution throughout life and in response to an obesogenic diet, it is unknown if neuronal-epithelial cell fusion is altered. Here, we sought to determine if neuronal-epithelial cell fusion frequency correlates with obesogenic diet consumption and age.

METHODS: Corneas were collected from C57BL/6 mice and evaluated for neuronal-epithelial cell fusion frequency using serial block-face scanning electron microscopy. To assess the …


Annual And Seasonal Variability In Tundra Vole (Microtus Oeconomus) Diet, Mary Kathleen Lisi May 2024

Annual And Seasonal Variability In Tundra Vole (Microtus Oeconomus) Diet, Mary Kathleen Lisi

Master's Theses and Capstones

Within arctic ecosystems, small mammals (voles and lemmings) influence plantcommunity composition, soil nutrient availability, and carbon cycling through foraging and the deposition of waste. Yet, little is known about rodent diet specifically and how it may vary annually and seasonally. Here, we characterize the composition and stability in tundra vole (Microtus oeconomus) diet in northern Alaska using stable isotope analysis of fecal and hair samples collected over a seven-year period. Results from Bayesian stable isotope mixing models from both fecal and hair sample data show that tundra voles in northern Alaska predominately feed on rhizomatous sedges, Eriophorum vaginatum and Carex …


Impact Of Sustained Calorie Restriction And Weight Cycling On Body Composition In High-Fat Diet-Fed Male And Female C57bl/6j Mice, Daniel L Smith, Yongbin Yang, Luis M Mestre, Beate Henschel, Erik Parker, Stephanie Dickinson, Amit Patki, David B Allison, Tim R Nagy May 2024

Impact Of Sustained Calorie Restriction And Weight Cycling On Body Composition In High-Fat Diet-Fed Male And Female C57bl/6j Mice, Daniel L Smith, Yongbin Yang, Luis M Mestre, Beate Henschel, Erik Parker, Stephanie Dickinson, Amit Patki, David B Allison, Tim R Nagy

Children’s Nutrition Research Center Staff Publications

Objective: The objective of this study was to investigate body composition changes with weight cycling (WC) among adult C57BL/6J mice with diet-induced obesity.

Methods: A total of 555 single-housed mice were fed a high-fat diet ad libitum (AL) from 8 to 43 weeks of age. The 200 heaviest mice of each sex were randomized to the following four groups: ever obese (EO, continued AL feeding); obese weight loser (OWL, calorie-restricted); obese weight loser moderate (OWLM, body weight halfway between EO and OWL); and WC (diet restricted to OWL followed by AL refeeding cycles). Body weight and composition data were collected. …


The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects Of Bile Acids, Sung Ho Lee, Ji Ho Suh, Mi Jeong Heo, Jong Min Choi, Yang Yang, Hyun-Jung Jung, Zhanguo Gao, Yongmei Yu, Sung Yun Jung, Mikhail G Kolonin, Aaron R Cox, Sean M Hartig, Holger K Eltzschig, Cynthia Ju, David D Moore, Kang Ho Kim May 2024

The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects Of Bile Acids, Sung Ho Lee, Ji Ho Suh, Mi Jeong Heo, Jong Min Choi, Yang Yang, Hyun-Jung Jung, Zhanguo Gao, Yongmei Yu, Sung Yun Jung, Mikhail G Kolonin, Aaron R Cox, Sean M Hartig, Holger K Eltzschig, Cynthia Ju, David D Moore, Kang Ho Kim

Faculty, Staff and Student Publications

Bile acids (BAs) are pleiotropic regulators of metabolism. Elevated levels of hepatic and circulating BAs improve energy metabolism in peripheral organs, but the precise mechanisms underlying the metabolic benefits and harm still need to be fully understood. In the current study, we identified orosomucoid 2 (ORM2) as a liver-secreted hormone (i.e., hepatokine) induced by BAs and investigated its role in BA-induced metabolic improvements in mouse models of diet-induced obesity. Contrary to our expectation, under a high-fat diet (HFD), our Orm2 knockout (Orm2-KO) exhibited a lean phenotype compared with C57BL/6J control, partly due to the increased energy expenditure. However, when challenged …


Research Proposal: The Effects Of Dietary Zinc On Adhd Signs And Symptoms In Teenage Females: A Randomized Controlled Trial, Sarai Logan, Andrea Villalba Torres, Amanda Miller Apr 2024

Research Proposal: The Effects Of Dietary Zinc On Adhd Signs And Symptoms In Teenage Females: A Randomized Controlled Trial, Sarai Logan, Andrea Villalba Torres, Amanda Miller

Department of Nutrition Student Projects

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder marked by inattention, hyperactivity, and impulsivity. ADHD presents difficulties for adolescents, affecting numerous areas of life. Recent research suggests a relationship between zinc deficiency and ADHD symptoms, encouraging interest in dietary interventions utilizing zinc. However, there is missing research regarding effects of zinc use for ADHD symptoms in young girls as the generalized research is geared toward boys who express ADHD characteristics differently. The objective of this study is to explore if zinc-rich diets may improve signs/symptoms in girls 13 to 17-years-old with ADHD. An intervention design will be adopted with …


Fad Diets And How They Work In The Human Body, Isabella Huner Apr 2024

Fad Diets And How They Work In The Human Body, Isabella Huner

Senior Honors Theses

Diets are often viewed as a quick fix to obtaining a goal weight or achieving a dream body. What people fail to understand are the processes that take place within the body while undergoing a particular diet. While some diets may aid in weight reduction, the harm put on the body is easily overlooked.

Through an in-depth analysis on three of the most popular fad diets—the ketogenic diet, intermittent fasting, and the Paleolithic diet—shows how the diet came about, how it works in the body from a basic to a cellular level, and the risks posed by these diets. Knowledge …


Effect Of The Mediterranean Diet On Type 2 Diabetes In Teens/Young Adults, Megan Herrera, Taylor Folwark, Christine Marti-Milward, Madison Benjamin Apr 2024

Effect Of The Mediterranean Diet On Type 2 Diabetes In Teens/Young Adults, Megan Herrera, Taylor Folwark, Christine Marti-Milward, Madison Benjamin

Department of Nutrition Student Projects

Type 2 Diabetes (T2D) is a chronic condition affecting roughly 422 million people worldwide. Diabetes is a metabolic condition that occurs when there are elevated blood sugar levels for long periods of time which could lead to damage within the heart, kidneys, blood vessels, eyes, and nervous system. T2D occurs due to the body’s resistance to insulin or insufficient production of insulin. T2D is prevalent among adults, but as time continues, a larger number of teens/young adults are being diagnosed with this condition. As research advances, there is evidence that indicates pharmacological treatments can be used to positively affect T2D. …


Hooked On A Feeling: The Importance Of Fostering Emotional Intelligence In Adolescents, Annika Wirkkala Apr 2024

Hooked On A Feeling: The Importance Of Fostering Emotional Intelligence In Adolescents, Annika Wirkkala

Classical Conversations

In the summer of 2023, CNN reported on a 14-year old girl who claimed to have several mental health issues. These included ADHD, depression, autism, and various phobias. After a specialist examined her, however, she was officially diagnosed not with her extensive list of illnesses but with severe anxiety. How did this 14-year old girl become so convinced that she suffered from all of these problems? Social media. Sadly, this girl is not the only victim of social media self-diagnosis. According to the CNN report, “A growing number of teens are turning to social platforms such as Instagram and TikTok …