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Glucan-Rich Polysaccharides From Pleurotus Sajor-Caju (Fr.) Singer Prevents Glucose Intolerance, Insulin Resistance And Inflammation In C57bl/6j Mice Fed A High-Fat Diet, G. Kanagasabapathy, U.R. Kuppusamy, S.N. Abd Malek, M.A. Abdulla, K.H. Chua, V. Sabaratnam

Research Publications (2011 to 2015)

Background: Pleurotus sajor-caju (P. sajor-caju) has been extremely useful in the prevention of diabetes mellitus due to its low fat and high soluble fiber content for thousands of years. Insulin resistance is a key component in the development of diabetes mellitus which is caused by inflammation. In this study, we aimed to investigate the in vivo efficacy of glucan-rich polysaccharide of P. sajor-caju (GE) against diabetes mellitus and inflammation in C57BL/6J mice fed a high-fat diet. Methods: Diabetes was induced in C57BL/6J mice by feeding a high-fat diet. The mice were randomly assigned to 7 groups (n=6 per group). The …

Diet, Bacteria And Inflammation: The Intestinal Mucosa And Metabolic Syndrome, Nadeem K. Mohammed

Theses and Dissertations--Nutritional Sciences

Long term consumption of a high fat diet (HFD) increases the risk of developing Metabolic Syndrome and type 2 diabetes. This led us to hypothesize that long term HFD consumption impairs immune tolerance to the intestinal bacteria. Our studies had two goals. First, we characterized the effect of long term HFD consumption on the systemic immune response by comparing C57BL6 mice fed a HFD and low fat diet (LFD). Plasma immunoglobulin G (IgG) against Escherichia coli (LF-82), E. coli (Nissle 1917), Bacteroides thetaiotaomicron and Lactobacillus acidophilus were measured by a lab-developed ELISA. Fasting blood glucose and inflammation were measured in …

Effects Of Lycopene On Plasma Glucose, Insulin Levels, Oxidative Stress, And Body Weights Of Streptozotocin-Induced Diabetic Rats, Muhsi̇n Aydin, Sefa Çeli̇k

Turkish Journal of Medical Sciences

To determine possible therapeutic effects of oral lycopene supplementation on plasma insulin levels, lipid peroxidation, blood glucose levels, and the antioxidant defense system of streptozotocin-induced diabetic rats. Materials and methods: Classical biochemical methods were used to determine plasma malondialdehyde (MDA), nitric oxide (NO), glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Enzyme-linked immunosorbent assay was used to determine plasma insulin levels and reverse transcriptase-polymerase chain reaction was used to determine the levels of brain antioxidant enzymes (SOD, CAT, and GSH-Px). Results: It was found that the diabetes-related increase in blood glucose levels was reduced by supplementation …

A Preliminary Examination Of A Program That Provides Free Blood Glucose Testing Meters, And Subsidies On Test-Strips To Adult Diabetics, Cecil White

Abraham S. Fischler College of Education ETD Archive

This applied dissertation was designed to conduct a preliminary examination of the effects of the provision of free glucose testing meters, and test-strips subsidies on blood glucose control among diabetics. The study examined whether there was any impact on the frequency of testing, and whether there was a correlation between the frequency of testing and blood sugar control, as measured by HbA1c tests.

The researcher conducted a study of the program using a quasi-experimental design, and used the Glucose Monitoring Patient Questionnaire to compare the results between a test group and a control group of participants. Independent t tests were …

Examining The Effect Of Maternal High-Fat Diet Consumption On The Physiology And Pancreas Development Of Fetal And Juvenile Nonhuman Primate Offspring, Sarah Michelle Comstock

Dissertations and Theses

The purpose of these studies was to investigate the impact of high-fat diet (HFD) exposure during pregnancy and the early post-natal period on fetal and post-natal development of the endocrine pancreas of the Japanese macaque. Specifically I hypothesized that the HFD would alter islet morphology and lead to disturbances in glucose homeostasis in these animals. Adult female Japanese macaques were placed on either a control (CTR) or HFD diet for 4 years. Fetuses were collected at gestational day 130 (G130), while other offspring from the CTR and HFD mothers were carried to term. After birth, infant animals were maintained with …

Evaluation Of Group Medical Visits In Improvement Of Diabetes Self-Management., Victoria M. Dobbins

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Diabetes is a chronic disease that has potential complications if left unmanaged that can lead to financial burden for all those who are involved along with life altering health impacts. Complications can be reduced with proper management of this chronic disease. Selfmanagement of diabetes has been linked to improved outcomes and therefore, decreased complications. Improvements of self-management of those patients with diabetes often require health care providers to look at unique approaches to the delivery of care. The use of group medical visit is one such approach that has been studied and linked to improvements of selfmanagement. However, there …

Implementation Of A Group Adult Type 2 Diabetes Mellitus Educational Program In A Rural Alabama Community Health Center, Janna Culpepper

Doctor of Nursing Practice (DNP)

No abstract provided.

Effectiveness Of Insulin Pump Use In Controlling Blood Glucose In Type 1 Diabetes Mellitus Patients, Nadia M. Saad

Master's Theses and Doctoral Dissertations

No abstract provided.

Sirtuin-1 Mediates The Obesity Induced Risk Of Common Degenerative Diseases: Alzheimer's Disease, Coronary Artery Disease And Type 2 Diabetes, Ian Martins, Andrea Wilson, Wei Ling Lim, Simon Laws, Stephanie Fuller, Ralph Martins

Research outputs 2012

Obesity, especially at mid-life, is a major risk factor for atherosclerosis, insulin resistance and the metabolic syndrome, which in turn contrib- ute to coronary artery disease (CAD), Type 2 diabetes and Alzheimer’s disease (AD). The rise in overweight and obesity in all societies is prompting intense research into the causes and effects of the condition. Obesity disrupts many body systems including glucose and lipid me- tabolism, circadian rhythms and liver function. It also causes or increases inflammation and oxi- dative stress. Within cells, the endoplasmic re- ticulum (ER) appears to be particularly suscep- tible to such metabolic disruption. Sirtuin 1 …

Structural Analysis Of Proinsulin Hexamer Assembly By Hydroxyl Radical Footprinting And Computational Modeling, Janna G. Kiselar, Manish Datt, Mark R. Chance, Michael A. Weiss

Faculty Scholarship

Mutations in the insulin gene can impair proinsulin folding and cause diabetes mellitus. Although crystal structures of insulin dimers and hexamers are well established, proinsulin is refractory to crystallization. Although an NMR structure of an engineered proinsulin monomer has been reported, structures of the wild-type monomer and hexamer remain undetermined. We have utilized hydroxyl radical footprinting and molecular modeling to characterize these structures. Differences between the footprints of insulin and proinsulin, defining a "shadow" of the connecting (C) domain, were employed to refine the model. Our results demonstrate that in its monomeric form, (i) proinsulin contains a native-like insulin moiety …

Pharmacists As Mid-Level Healthcare Providers And The Clinical Results Of A Pharmacist-Led Diabetes Disease Management Program., Benjamin Maurice Risner 1983-

Electronic Theses and Dissertations

Advancements in medical therapy have augmented resources available to physicians to treat disease and, because of this, spending on prescription drugs has doubled in the past decade. Increasingly, clinical trials are demonstrating the benefits of aggressive disease management in reducing morbidity and mortality. Physicians treating patients with chronic conditions must balance the benefits of combination drug therapy against the risk of adverse drug events and drug interactions. For instance, evidence-based practice guidelines in patients with diabetes and multiple comorbidities require combination therapy in order to reduce morbidity and mortality. Patients with polymorbidity require the attention of multiple physicians, further fragmenting …

Delayed Onset Muscle Soreness In People With Diabetes; Biomarkers And Nutritional Supplementation, Hani H. Al-Nakhli

Loma Linda University Electronic Theses, Dissertations & Projects

Exercise is important for controlling hemoglobin A1c, and maintaining proper glycemic control in people with diabetes. Exercise also increases the diabetics overall insulin sensitivity, and decreases their dependency on diabetes medication. However, people with diabetes are faced with metabolic and endothelial impairment, which could result in a prolonged sensation of muscle soreness following exercise. This would make it difficult for these people to sustain exercise regimes. Delayed-onset muscle soreness (DOMS) is a common problem in healthy individuals and in people who have diabetes. DOMS is a painful sensation experienced by individuals who have been recently inactive and then over-exercise. Yet, …

Age At Diagnosis Of Diabetes In Appalachia, Lawrence Barker, Robert Gerzoff, Richard Crespo, Molly Shrewsberry

Family and Community Health

Background

Appalachia is a region of the United States noted for the poverty and poor health outcomes of its residents. Residents of the poorest Appalachian counties have a high prevalence of diabetes and risk factors (obesity, low income, low education, etc.) for type 2 diabetes. However, diabetes prevalence exceeds what these risk factors alone explain. Based on this, the history of poor health outcomes in Appalachia, and personally observed high rates of childhood obesity and lack of concern about prediabetes, we speculated that people in Appalachia with diagnosed diabetes might tend to be diagnosed younger than their non-Appalachian counterparts.

Methods …

The Effectiveness Of Diabetes Mellitus Education For Managing Hemoglobin A1c Levels In Adults, Amy Rebekah Farnsworth

Theses and Dissertations

Hemoglobin A1c (HbA1c) levels are indicators for managing Diabetes Mellitus. This study investigated the effectiveness of Diabetes Mellitus education classes based on participants’ HbA1c levels. The HbA1c and body mass index (BMI) values were analyzed using t-tests to determine significant (P ≤ 0.05) differences between baseline (N = 46) levels compared to three months, six months, and 12 months after class participation and reported as means ± standard deviations. The study was not able to track all participants as some did not attend all follow-up sessions. Mean HbA1c levels were lower at three months (8.1% ± 2.1, P = 0.002, …

Diabetes Prevalence Is Associated With Serum 25-Hydroxyvitamin D And 1,25-Dihydroxyvitamin D In Us Middle-Aged Caucasian Men And Women: A Cross-Sectional Analysis Within The Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial, Kaye E. Brock, Wen-Yi Huang, David R. Fraser, Liang Ke, Marilyn Tseng, Rebecca S. Mason, Rachael Z. Stolzenberg-Solomon, D. Michal Freedman, Jiyoung Ahn, Ulrike Peters, Catherine Mccarty, Bruce W. Hollis, Regina G. Ziegler, Mark P. Purdue, Barry I. Graubard

Kinesiology and Public Health

Hypovitaminosis D may be associated with diabetes, hypertension and CHD. However, because studies examining the associations of all three chronic conditions with circulating 25-hydroxyvitamin D (25(0H)D) and 1,25-dihydroxyvitamin D (1,25(0H)₂D) are limited, we examined these associations in the US Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (n 2465). Caucasian PLCO participants selected as controls in previous nested case-control studies of 25(0H)D and 1,25(0H)₂D were included in this analysis. Diabetes, CHD and hypertension prevalence, risk factors for these conditions and intake of vitamin D and Ca were collected from a baseline questionnaire. Results indicated …

Anticipating U.S. Population-Level Health And Economic Impacts Using Discrete-Event Simulation To Guide Health Policy Decisions, Odette Reifsnider

All Dissertations

This dissertation presents two applications of discrete-event simulation (DES) to represent clinical processes: (1) a model to quantify the risk of the maternal obese and diabetic intrauterine environment influence on progression to adult obesity and diabetes, and (2) a model to evaluate health and economic outcomes of different smoking cessation strategies. The first application considers the public health impact of the diabetic and obese intrauterine environment's effect on the prevalence of diabetes and obesity across subsequent generations. We first develop a preliminary DES model to investigate and characterize the epidemiology of diabetes during pregnancy and birth outcomes related to maternal …

Association Study Of Candidate Gene Polymorphisms And Obesity In A Young Mexican-American Population From South Texas, Jorge Duran-Gonzalez, Ixiu Ortiz, Enrique Gonzales, Nicole Ruiz, Manti Ortiz, Arthur Gonzalez, Edna K. Sanchez, Eugenia Curet, Susan P. Fisher-Hoch, Anne R. Rentfro, Saraswathy Nair

Health & Biomedical Sciences Faculty Publications

Background and Aims

Obesity is increasingly a health problem and a risk factor for diabetes in young Mexican-American populations. Genetic association studies in older, mostly non-Hispanic populations have reported that polymorphisms in the candidate genes HSD11B1, CRP, ADIPOQ, PPARG, ANKK1, ABCC8 and SERPINF1 are associated with obesity or diabetes. We analyzed the polymorphisms rs846910, rs1205, rs1501299, rs1801282, rs1800497, rs757110 and rs1136287in these candidate genes, for association with obesity and metabolic traits in a young Mexican-American population from south Texas.

Methods

Genotyping of the seven common SNPs were performed by allelic discrimination assays in 448 unrelated Mexican Americans (median age = …

Quantifying Polypharmacy In Diabetes Patients In The U.S., Jing Tao

Theses and Dissertations

ix Objectives: To quantify polypharmacy and assess the socio-economic predictors of medication use and expenditure in diabetics. Methods: This study analyzed adult diabetes patients using a nationally representative sample in Medical Expenditure Panel Survey in 2006. Top ten most highly utilized drug classes were identified. Descriptive statistics were used to portray the patients’ medication utilization and spending. Generalized linear models were conducted to assess the socio-economic variants in drug use and spending. Results: On average, a diabetes patient had 45 prescriptions in 2006, for total annual spending of $3,161. A diabetes patient used drugs from 3.43 classes within top ten …

Modifiable Disease Risk, Readiness To Change, And Psychosocial Functioning Improve With Integrative Medicine Immersion Model, Ruth Q. Wolever, Daniel M. Webber, Justin P. Meunier, Jeffrey M. Greeson, Evangeline R. Lausier, Tracy W. Gaudet

College of Science & Mathematics Departmental Research

Background—Stroke, diabetes, and coronary heart disease (CHD) remain leading causes of death in the United States and are largely attributable to lifestyle behaviors. Integrative medicine can provide a supportive partnership that focuses on improving health by identifying and implementing lifestyle changes based upon personal values and goals.

Objective—This prospective observational study was designed to assess the effectiveness of an integrative medicine intervention on modifiable disease risk, patient activation, and psychosocial risk factors for stroke, diabetes, and CHD.

Design—Sixty-three adults participated in a 3-day comprehensive, multimodal health immersion program at Duke Integrative Medicine, Duke University Medical Center, Durham, North Carolina. Participants …

Development Of A Proposed Community Action Plan For The Juvenile Diabetes Research Foundation, Alicia Milla, Alexis Rodriguez

Community Engagement and Collaboration

The Juvenile Diabetes Research Foundation (JDRF) is a national organization that was started back in 1970 by two mothers of sons with type 1 diabetes. Since its founding, JDRF has awarded more than $1.5 billion to diabetes research around the world, including $9.9 million of research in San Diego. JDRF is a volunteer-driven organization with thousands of volunteers in locations worldwide. While JDRF is working hard to find a cure and improve the lives of those living with type 1 diabetes, it also has a goal of providing volunteer-led support programs to people with type 1 diabetes and their families. …

Appalachian Regional Model For Organizing And Sustaining County-Level Diabetes Coalitions, Richard Crespo, Molly Shrewsberry, Darrlyn Cornelius-Averhart, Henry B. King Jr.

Family and Community Health

This article describes a model for developing diabetes coalitions in rural Appalachian counties and presents evidence of their sustainability. The rural Appalachian coalition model was developed through a partnership between two federal agencies and a regional university. Coalitions go through a competitive application process to apply for one-time $10,000 grants. The project has funded 7 to 9 coalitions annually since 2001, reaching 66 total coalitions in 2008. Sustainability of the coalitions is defined by the number of coalitions that voluntarily report on their programs and services. In 2008, 58 of 66 (87%) coalitions in the Appalachian region continue to function …

Interventions To Improve The Management Of Medically Uninsured Adult Patients With Type 2 Diabetes Mellitus In Primary Care, Community-Based Settings, Lynn Miskovich

Evidence-Based Practice Project Reports

This project measured the effect of a clinical algorithm on the provision of care to medically uninsured adult patients with type 2 diabetes and a low socioeconomic status (SES). Primary providers often fail to implement established standards for diabetes care to their maximal benefit and do not achieve American Diabetes Association (ADA) treatment standards. Saydah, et al. (2004) reported that only 48% of patients with diabetes achieved the recommended HbA1c goal, and 33% reached blood pressure and LDL targets. Goals for all three clinical parameters were obtained by only 7% of patients. The Stetler Model of Evidence-based Practice (EBP) provided …

The Relationship Between Physical Activity Recommendations And Diabetes Risk Factors In Pregnant Women, Kelly Mattran

Masters Theses, 2010-2019

BACKGROUND: Changes in maternal insulin sensitivity throughout pregnancy may help supply nutrients to a growing fetus; however, the changes may concomitantly increase the mother and child’s risk for diabetes and chronic diseases. Regular physical activity (PA) positively impacts precursors for diabetes, but the impact of PA throughout gestation is less studied. The purpose of this study was to examine the relationship between meeting PA recommendations and diabetes risk in pregnant women. METHODS: A total of 23 pregnant women were recruited for participation. Venous blood samples, questionnaires, and anthropometric measurements (height, weight, and hip/waist circumferences) were ascertained during a single session. …

Improvement In Nutrition Knowledge And Retention About Gestational Diabetes Mellitus Among Hispanic Pregnant Women, Debra M. Waldron

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Objective: The objectives of this study were to evaluate the demographic data of the study population, compare nutrition knowledge and retention in Hispanic pregnant women who were newly diagnosed with gestational diabetes (GDM) or with a history of GDM at time of GDM diagnosis and prior to delivery, and determine if the Sweet Success education program’s curriculum was effective in improving overall knowledge in pregnant women with GDM.

Design: A quasi-experimental design was used with a convenience sample.

Subjects/Setting: Ninety women between the ages of 18 and 45 years and of Hispanic or Hispanic American descent were recruited for this …

Template To Improve Glycemic Control Without Reducing Adiposity Or Dietary Fat, R. Krishnapuram, E. J. Dhurandhar, O. Dubuisson, H. Kirk-Ballard, S. Bajpeyi, N. Butte, M. S. Sothern, E. Larsen-Meyer, S. Chalew, B. Bennett, A. K. Gupta, F. L. Greenway, W. Johnson, M. Brashear, G. Reinhart, T. Rankinen, C. Bouchard, W. T. Cefalu, J. Ye, R. Javier, A. Zuberi, N. V. Dhurandhar

Faculty Publications

Drugs that improve chronic hyperglycemia independently of insulin signaling or reduction of adiposity or dietary fat intake may be highly desirable. Ad36, a human adenovirus, promotes glucose uptake in vitro independently of adiposity or proximal insulin signaling. We tested the ability of Ad36 to improve glycemic control in vivo and determined if the natural Ad36 infection in humans is associated with better glycemic control. C57BL/6J mice fed a chow diet or made diabetic with a high-fat (HF) diet were mock infected or infected with Ad36 or adenovirus Ad2 as a control for infection. Postinfection (pi), systemic glycemic control, hepatic lipid …

Engineering An Optimal Bioartificial Pancreas For Islet Transplantation Using Bioactive Scaffolds, Eileen Pedraza

Open Access Dissertations

Clinical islet transplantation is a promising treatment for type 1 diabetes. It involves the transplantation of pancreatic islets, isolated from a donor, into the portal vein of a recipient in order to replace his/her dysfunctional islets. Though promising, islet implantation into the liver is greatly hindered by numerous problems, including mechanical stresses, inflammatory responses, exposure to high drug and toxin loads, as well as irretrievability. In order to address these concerns, investigation into alternative implant sites, such as the subcutaneous site, has intensified. Transplantation of islets within these extrahepatic sites is commonly met with three primary obstacles: 1) inadequate spatial …

Diet And Disease: Subsistence Change And Tuberculosis Among The Pawnee, Omaha And Winnebago In The Nineteenth Century, Owen J. O'Reilly

Department of Anthropology: Theses and Student Research

The mid- to late nineteenth century was the beginning of the reservation era for most Native Americans, ushering in a series of unprecedented changes that affected the cultural traditions and physical health of groups across the United States. For the Pawnee, Omaha and Winnebago in Nebraska, changes in subsistence patterns not only destroyed traditions but influenced the spread of disease and malnutrition. Government rations, consisting largely of wheat flour, beef, bacon, pork, sugar and coffee, were a drastic departure from the traditional diet of lean bison meat, corn, beans, squash and wild food and those who depended on these rations …

Identifying Postpartum Intervention Approaches To Preventing Type 2 Diabetes In Women With A History Of Gestational Diabetes, Jacinda M. Nicklas, Chloe A. Zera, Ellen W. Seely, Zainab S. Abdul-Rahim, Noelle D. Rudloff, Sue E. Levkoff

Faculty and Staff Publications

Background: Women who develop gestational diabetes mellitus (GDM) have an increased risk for the development of type 2 diabetes. Despite this "window of opportunity," few intervention studies have targeted postpartum women with a history of GDM. We sought perspectives of women with a history of GDM to identify a) barriers and facilitators to healthy lifestyle changes postpartum, and b) specific intervention approaches that would facilitate participation in a postpartum lifestyle intervention program.

Methods: We used mixed methods to gather data from women with a prior history of GDM, including focus groups and informant interviews. Analysis of focus groups relied on …

Diabetes Understanding Among Staff Nurses: Examining The Actual Versus Perceived Knowledge In The Acute Care Setting, Rebecca B. Ledbetter

Nursing Theses and Capstone Projects

Diabetes is the fourth leading cause of death world-wide claiming a staggering 3.8 million lives globally each year to related complications (World Health Organization, 2011). Diabetes complications account for 20% of all acute care admissions or 1 in every 5 patients have a diabetes-related condition (American Diabetes Association, 2011). Patient education in the areas of lifestyle modification, healthy eating habits, and proper medication administration is research-supported to clinically decrease the likelihood of acute complications. Bedside, acute care nurses are at the front line of patient education delivery and have the opportunity to determine behavioral stages related to a patient's readiness …

Enablers And Deterrents To Self-Care Behavior Of Filipinos With Diabetes, Stimson F. Agustin Jr.

CNU Journal of Higher Education

ABSTRACT This qualitative study focused on the enablers and deterrents of self-care behavior among Filipino adults with Type 2 Diabetes. Purposive sampling was used to recruit participants. Open-ended interviews with diabetic patients and their primary caregivers and self-care diaries were utilized as methods of data collection. Further, review of medical records was done.A “within-case analysis”, (triangulated data from diabetic patients and caregivers) and a “cross-case analysis” (comparing triangulated data among and across all cases) were undertaken, noting a specific pattern-match. Moreover, a constant comparison method with data and review extant literature was done.Different enablers and deterrents to self-care surfaced and …