Digital Commons Network^™

Resistant Starch As A Dietary Intervention To Limit The Progression Of Diabetic Kidney Disease, Anna M. Drake, Melinda T. Coughlan, Claus T. Christophersen, Matthew Snelson

Research outputs 2022 to 2026

Diabetes is the leading cause of kidney disease, and as the number of individuals with diabetes increases there is a concomitant increase in the prevalence of diabetic kidney disease (DKD). Diabetes contributes to the development of DKD through a number of pathways, including inflammation, oxidative stress, and the gut-kidney axis, which may be amenable to dietary therapy. Resistant starch (RS) is a dietary fibre that alters the gut microbial consortium, leading to an increase in the microbial production of short chain fatty acids. Evidence from animal and human studies indicate that short chain fatty acids are able to attenuate inflammatory …

Higher Adherence To A Mediterranean Diet Is Associated With Improved Insulin Sensitivity And Selected Markers Of Inflammation In Individuals Who Are Overweight And Obese Without Diabetes, Surbhi Sood, Jack Feehan, Catherine Itsiopoulos, Kirsty Wilson, Magdalena Plebanski, David Scott, James Hébert Scd, Nitin Shivappa Mbbs, Mph, Ph.D., Aya Mousa, Elena S. George, Barbora De Courten

Faculty Publications

Insulin resistance (IR) and chronic low-grade inflammation are risk factors for chronic diseases including type 2 diabetes (T2D) and cardiovascular disease. This study aimed to investigate two dietary indices: Mediterranean Diet Score (MDS) and Dietary Inflammatory Index (DII®), and their associations with direct measures of glucose metabolism and adiposity, and biochemical measures including lipids, cytokines and adipokines in overweight/obese adults. This cross-sectional study included 65 participants (males = 63%; age 31.3 ± 8.5 years). Dietary intake via 3-day food diaries was used to measure adherence to MDS (0–45 points); higher scores indicating adherence. Energy-adjusted DII (E-DII) scores were calculated with …

Bioactive Food Components And Their Inhibitory Actions In Multiple Platelet Pathways, Diptimayee Das, Shubhamay Adhikary, Ranjit Kumar Das, Antara Banerjee, Arun Kumar Radhakrishnan, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

Health & Biomedical Sciences Faculty Publications

In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis. Platelets' hemostatic and non-hemostatic functions are mediated by the expression of various membrane receptors and the release of proteins, ions and other mediators. Therefore, specific activities of platelets responsible for the non-hemostatic disease are to be inhibited while leaving the platelet's hemostatic function unaffected. Platelets' anti-aggregatory property has been used as a primary criterion for antiplatelet drugs/bioactives; however, their non-hemostatic activities are not well known. This review describes the hemostatic and non-hemostatic function of human blood …

The Reported External Traumas Among People With Diabetes-Related Foot Ulcers And Their Outcomes: A Systematic Review Of Case Reports, Ma'en Zaid Abu-Qamar, Vivien Kemp, Lisa Whitehead

Research outputs 2022 to 2026

The objective of this systematic review was to collate evidence published in case reports on the reported origins of external traumas that contribute to the development of diabetic foot ulcers and their outcomes. The review also aimed to suggest reporting criteria for external traumas contributing to the development of diabetic foot ulcers. The search strategy led to the identification of 1224 articles across six electronic databases. Additional articles were also sourced from other electronic platforms (Google scholar) and the reference lists of the included case reports. Ninety-four articles met the inclusion criteria and were published between 1989 and 2020. The …

Chronic Illness Education 2022: Helping Patients Access Low-Cost Diabetes Supplies And Medications, Iyanna Peppers, Laial Baltaji, Lucas Edgren, Lyndsay Archer, Molly Wilson

Patient Education Projects

No abstract provided.

Webinars As A Tool For Increasing Awareness Of Diabetes Prevention And Management Programs, Cindy Jenkins, Carrie Durward, April Litchford, Catherine Hansen, Annette Prall, Caitlyn Jasumback

Outcomes and Impact Quarterly

Stakeholders sought to reduce the burden of preventable diabetes among adults in Utah via a “Food as Medicine” webinar series. The “Food as Medicine” webinar series sought to increase awareness of and enrollment in public diabetes programs. Evaluation results from the webinar series indicated an increase in awareness of diabetes programs and nutrition information needed to improve personal diabetes management.

Prevalence Of Health-Risk Behaviours Among Indigenous Australians With Diabetes: A Review, Sharon Atkinson-Briggs, Alicia Jenkins, Christopher Ryan, Laima Brazionis

Journal of the Australian Indigenous HealthInfoNet

Aboriginal and Torres Strait Islander Australians are at high risk of Type 2 diabetes and its complications. Optimal lifestyle choices can improve health outcomes. A thematic review of original research publications related to smoking, nutrition, alcohol intake, physical activity and emotional wellness in Aboriginal and Torres Strait Islander Australians with diabetes was performed. Overall, 7118 English-language publications were identified by search engines (PubMed, CINAHL, Scopus, Medline-Web of Science, and Google Scholar) with search terms Indigenous Australians OR Aboriginal and Torres Strait Islanders AND diabetes AND lifestyle OR smoking OR nutrition OR alcohol OR physical activity OR emotional wellbeing and their …

Impact Of Vitamin D Elements And Osteoporosis Factors In Postmenopausal Iraqi Women With T2dm, Howraa Alkabi, Wafaa Alfatlawi, Muhammed Aldabagh

Journal of Applied Sciences and Nanotechnology

Osteoporosis is a systematic bone disorder characterized by bone mass loss and bone tissue architectural degeneration. The incidence of osteoporosis in women increases with age, reflecting the considerable increase in bone loss rate in postmenopausal women once estrogen loses its protective influence. The purpose of this study was to determine the levels of Osteocalcin, Vitamin D, and other parameters that influence bone quality and increased bone fragility in postmenopausal Iraqi women with type 2 diabetes mellitus (T2DM). The levels of vitamin D receptor and vitamin D binding protein in serum are studied for the first time in our study. The …

September 2022, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

National Childhood Obesity Awareness Month

About 1 in 5 American children has obesity. Compared to children with healthy weight, children with overweight or obesity are at a higher risk for asthma, sleep apnea, bone and joint problems, type 2 diabetes, and heart disease.

Meta-Analysis: Outcomes Of Surgical And Medical Management Of Diabetic Foot Osteomyelitis, David H. Truong, Roger Bedimo, Matthew Malone, Dane K. Wukich, Orhan Oz, Amanda L. Killeen, Lawrence A. Lavery

School of Podiatric Medicine Publications

Background

The aim of this study was to evaluate clinical outcomes in the published literature on medical and surgical management of diabetic foot osteomyelitis (DFO).

Methods

A PubMed and Google Scholar search of articles relating to DFO was performed over the dates of January 1931 to January 2020. Articles that involved Charcot arthropathy, case reports, small case series, review articles, commentaries, nonhuman studies, and non-English articles were excluded. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool was used to rate the bias of each study. A meta-analysis was performed using random-effects and inverse variance methods. The search yielded 1192 …

Efficacy Of Various Interventions For Achieving Target Hba1c Levels For Patients With Type Ii Diabetes Mellitus And On Exogenous Insulin, Caitlin S. Welch, Archie Troxel

Longitudinal Scholar's Project

Objective: To learn the rates at which patients at UT Family Medicine–St. Francis (UTFM–SF) with type II diabetes mellitus are being prescribed recommended medications—namely metformin, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and glucagon-like peptide 1 receptor agonists (GLP1RAs)—whether these rates correspond to the severity of hyperglycemia (as indicated by HbA1C level). A secondary goal of the study was to investigate if HbA1C levels are being checked at recommended intervals.

Methods: A retrospective chart review was conducted using records of patients seen at the clinic in the previous four years between the ages of 18 and 65 who had visits with ICD …

A Structural Equation Modeling Analysis To Explore Diabetes Self-Care Factors In A Rural Sample, Laurie Abbott, Lucinda Graven, Glenna Schluck, Jennifer Lemacks

Faculty Publications

Diabetes is a public health problem that requires management to avoid health sequelae. Little is known about the determinants that influence diabetes self-care activities among rural populations. The purpose of this analysis was to explore the relationships among diabetes self-care activities, diabetes knowledge, perceived diabetes self-management, diabetes fatalism, and social support among an underserved rural group in the southern United States. A diabetes health promotion program was tested during a cluster randomized trial that tested a disease risk reduction program among adults living with prediabetes and diabetes. A structural equation model was fit to test psychosocial factors that influence diabetes …

Improving Measurements And Self-Management Skills Of Cardiovascular Disease By Incorporating A Healthy Lifestyle In Hispanic Adults: A Promotoras Led Program, Kelly Llewellyn

Doctor of Nursing Practice (DNP) Manuscripts

Hispanic community members face unique challenges related to language barriers, culture, access to care, and trust in healthcare providers. Hispanic community members have a higher incidence of cardiovascular diseases and diabetes than their non-Hispanic counterparts. Hispanic males were most likely to die of cardiovascular disease in 2017 (CDC, n.d.a), and for females, death from cardiovascular disease was only second to cancer (CDC, n.d.b.). Hispanics are 70% more likely to be diagnosed with diabetes than non-Hispanics (Office of Minority Health, nd.) Promotoras are trusted members of the Hispanic community who can assist healthcare providers in providing disease prevention education and self-management …

Estimating The Health Effects Of Adding Bicycle And Pedestrian Paths At The Census Tract Level: Multiple Model Comparison, Ross J. Gore, Christopher Lynch, Craig Jordan, Andrew Collins, R. Michael Robinson, Gabrielle Fuller, Pearson Ames, Prateek Keerthi, Yash Kandukuri

VMASC Publications

Background: Adding additional bicycle and pedestrian paths to an area can lead to improved health outcomes for residents over time. However, quantitatively determining which areas benefit more from bicycle and pedestrian paths, how many miles of bicycle and pedestrian paths are needed, and the health outcomes that may be most improved remain open questions.

Objective: Our work provides and evaluates a methodology that offers actionable insight for city-level planners, public health officials, and decision makers tasked with the question “To what extent will adding specified bicycle and pedestrian path mileage to a census tract improve residents’ health outcomes over time?” …

The Importance Of Education In The Management Of Diabetes, Taylor Nicole Henry

Doctoral Dissertations and Projects

Type 2 diabetes continues to affect millions of people every day across the United States. Uncontrolled blood sugars pose a risk to individuals’ overall health by causing microvascular and macrovascular changes and ultimately lead to an earlier mortality. One’s blood sugar levels can be checked at any time, but an individual’s hemoglobin (hgb) A1c is a three-month average that allows the diabetic to have an overview on how they are managing their diabetes. Appropriate nutrition and having someone hold the diabetic accountable have proven to limit these risks by lowering the patient’s hgb A1c. Providers and staff need to do …

An Evaluation Of A Multidisciplinary Implementation Of Evidence Based Practice In Prediabetes, Emily Sisco

Dissertations

Abstract

Problem Over 70% of prediabetic patients progress to full diabetes. There are over 80 million American adults who are diabetic. Diabetes is the costliest chronic disease that often leads to many other health issues.

Methods This QI project utilized a descriptive observational design. Quantitative data was collected via retrospective chart review. Primary data collected was documentation of a patient visit to the registered dietician and the hemoglobin A1c (HbA1c) of patients who followed up in the office after the referral.

Results Eight patients followed up to the office for a second visit (n=8). Four patients did see the registered …

A Review Of Covid-19 In Relation To Metabolic Syndrome: Obesity, Hypertension, Diabetes, And Dyslipidemia, Elias Makhoul, Joseph L. Aklinski, Jesse Miller, Cara Leonard, Sean Backer, Payal Kahar, Mayur S. Parmar, Deepesh Khanna

HPD Articles

Although severe cases and mortality of coronavirus disease 2019 (COVID-19) are proportionally infrequent, these cases are strongly linked to patients with conditions of metabolic syndrome (obesity, hypertension, diabetes, and dyslipidemia). However, the pathophysiology of COVID-19 in relation to metabolic syndrome is not well understood. Thus, the goal of this secondary literature review was to examine the relationship between severe acute respiratory syndrome (SARS-CoV-2) infection and the individual conditions of metabolic syndrome. The objective of this secondary literature review was achieved by examining primary studies, case studies, and other secondary studies, to obtain a comprehensive perspective of theories and observations of …

The Epidemiology Of Biliary Atresia: Exploring The Role Of Developmental Factors On Birth Prevalence, Laurel Cavallo, Erin M Kovar, Amal Aqul, Lucille Mcloughlin, Naveen K Mittal, Norberto Rodriguez-Baez, Benjamin L Shneider, Robert J Zwiener, Tiffany M Chambers, Peter H Langlois, Mark A Canfield, A J Agopian, Philip J Lupo, Sanjiv Harpavat

Faculty, Staff and Students Publications

OBJECTIVE: To identify key epidemiologic factors relevant to fetal development that are associated with biliary atresia.

STUDY DESIGN: This population-based registry study examined infants born in Texas between 1999 and 2014. Epidemiologic data relevant to fetal development were compared between cases of biliary atresia identified in the Texas Birth Defects Registry (n = 305) vs all live births (n = 4 689 920), and Poisson regression was used to calculate prevalence ratios (PRs) and 95% CIs.

RESULTS: The prevalence of biliary atresia over the study period was 0.65 per 10 000 live births. Biliary atresia was positively associated with female …

Smartphone Apps For Diabetes Medication Adherence: Systematic Review, Sheikh Mohammed Shariful Islam, Vinaytosh Mishra, Muhammad U Siddiqui, Jeban Chandir Moses, Sasan Adibi, Lemai Nguyen, Nilmini Wickramasinghe

Division of Internal Medicine Faculty Papers & Presentations

Background: Diabetes is one of the leading noncommunicable chronic diseases globally. In people with diabetes, blood glucose levels need to be monitored regularly and managed adequately through healthy lifestyles and medications. However, various factors contribute to poor medication adherence. Smartphone apps can improve medication adherence in people with diabetes, but it is not clear which app features are most beneficial.

Objective: This study aims to systematically review and evaluate high-quality apps for diabetes medication adherence, which are freely available to the public in Android and Apple app stores and present the technical features of the apps.

Methods: We systematically searched …

Vitamin D Deficiency, Its Relation To Bone, Back Pain, Tiredness And Mood Improving In Adult Sample Collected From Baghdad City, Abass T. Al Joudi, Mohammed Raad Khalaf

Al-Esraa University College Journal for Medical Sciences

Vitamin D deficiency is a global health problem. With all the medicall advances of the century, vitamin D deficiency is still prevailing. Over a billion people worldwide are Vitamin D deficient or insufficient. In this study data collected from 58 outpatients Clinic from Bagdad citw/Iraq, suffering from Vitamin D deficiency at different rate. They were either suffer from Vitamin D deficiency (10-19) ng/ml, insufficient (20-29) ng/ml or some sutfer with sever deficiency< 10ng/ml. This study covered random samples of different gender (male and female) and from different life style, which include different symptoms (bone and back pain, tiredness, hair loss and mood improving). Results showed that women were more accessible than men for Vitamin D deficiency due to woman loss more Vitamin Dthrough menopause, pregnancy and lactation period and results showed that patients with age (40 to 59) year old and (60 to 69) year old were suffering from bone and back bone pain, were 25% of the sample study were suffering from hair loss. Most people covered in this study were felling tiredness and headache. Inthisstudy samplescollected from patients with Vitamin D deficiencies were treated by giving dosages of supplement medicine (like Cholecalciferoll and Colecaliciferol) to optimize level of 25-OH Vitamin D3. To increase Vitamin D rate in these patients. Results also showed that the supplement medicine help and improve reducing hair loss, bone and back pain within two months of taken it, were 25% of the sample study suffering from felling tiredness and headache which they start to recovered their health gradually after taken medication within first and second month of treatment. In relation to depression, it was concluded that depression was associated with low Vitamin D level in patients' especially old peoples and from the results, medical supplement found to be improves mood and reduce depression in a sample of people study especially in women.

Circadian Clock, Diurnal Glucose Metabolic Rhythm, And Dawn Phenomenon, Fei Peng, Xin Li, Fang Xiao, Ruxing Zhao, Zheng Sun

Faculty, Staff and Students Publications

The circadian clock provides cue-independent anticipatory signals for diurnal rhythms of baseline glucose levels and glucose tolerance. The central circadian clock is located in the hypothalamic suprachiasmatic nucleus (SCN), which comprises primarily GABAergic neurons. The SCN clock regulates physiological diurnal rhythms of endogenous glucose production (EGP) and hepatic insulin sensitivity through neurohumoral mechanisms. Disruption of the molecular circadian clock is associated with the extended dawn phenomenon (DP) in type 2 diabetes (T2D), referring to hyperglycemia in the early morning without nocturnal hypoglycemia. The DP affects nearly half of patients with diabetes, with poorly defined etiology and a lack of targeted …

Social Determinants Of Diabetes In Hampton Roads, Virginia, Priyadarshini Pattath

Virginia Journal of Public Health

Background: Recent research demonstrates the need to consider social and economic factors that are the determinants of diabetes along with individual factors. Although the average crude rate of diabetes in Virginia is 10.9%, some of the census tracts report a much higher rate. Neighborhoods in places like Norfolk, Newport News and Portsmouth in Virginia have a diabetes prevalence rate of around 25%. Using a multilevel approach for diabetes interventions will have a much better outcome as social determinants play a significant role in diabetes-related health disparities.

Method: Diabetes prevalence data in seven cities of Hampton Roads, Virginia was linked to …

The Ventromedial Hypothalamic Nucleus: Watchdog Of Whole-Body Glucose Homeostasis, Longlong Tu, Makoto Fukuda, Qingchun Tong, Yong Xu

Children’s Nutrition Research Center Staff Publications

The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known for its involvement in glucose sensing and whole-body glucose homeostasis. However, it is still not fully understood how the brain detects and responds to the changes in the circulating glucose levels, as well as brain-body coordinated control of glucose homeostasis. In this review, we address the growing evidence implicating the brain in glucose homeostasis, especially in the contexts of hypoglycemia and diabetes. In addition to neurons, we emphasize the potential roles played by non-neuronal cells, as well as extracellular matrix in the hypothalamus in whole-body glucose homeostasis. Further, …

Assessing Preventative Lifestyle Interventions In The Filipino-American Population To Decrease Risk Of Type Ii Diabetes, Brandon Christopher Flores

Nursing | Senior Theses

Background

Type II Diabetes is a concerning global health issue and must be addressed. Given the unfortunate risks of T2D in the Filipino populations, prevention efforts must begin in this select population. There is strong empirical support for utilizing lifestyle interventions such as nutrition and physical exercise to prevent these diseases in adults; but it is not clear whether the same holds true for Filipino populations.

Objective

This thesis examines lifestyle management efforts such as weight reduction, family support, nutrition changes, and physical activity to prevent type 2 diabetes in Filipino-Americans.

Methods

The methods of the thesis will present a …

Dialysis Patient Education On The Prevention Of Kidney Disease Prior To Patients Receiving Dialysis: A Retrospective Descriptive Study, Jamie D. Jones

ATU Theses and Dissertations 2021 - Present

Fifty-two adult patients at an outpatient dialysis center in central Arkansas were surveyed regarding the education that was provided by medical professionals related to kidney disease and dialysis during treatment of hypertension and diabetes. The twenty-question survey inquired about demographic information, medical history, and the timing and perceived comprehension of education received. The researcher discovered that the majority of patients did not receive education that identified hypertension and diabetes as contributing factors of kidney disease until after diagnosis of kidney disease. The vast majority of participants reported that education regarding the life implications of dialysis, including fluid and dietary restrictions, …

Benefits Of Fasting In Adults Long Term, Talea Jones

Nursing | Senior Theses

In nursing education, we are often taught that through diet, exercise and medications one is able to live a healthy life. Fasting is not a subject that readily comes to mind as a way to prevent chronic illnesses from occurring. However, for years, cultures have used fasting as a way to replenish themselves and to clean themselves as if they were new beings. Nursing education does not highlight the process of fasting in any way close to the extent that medications are prescribed to control illnesses.

There are many types of fasting that are used in the United States. Fasting …

Epigenetics As Primary Prevention Of Coronary Artery Disease, David Majewski

Physician Assistant Scholarly Project Papers

This systematic literature review intended to ascertain if epigenetic testing for the primary prevention of Coronary Artery Disease (CAD) decreases mortality compared to the current standard of care. This systemic review used PubMed and Cochrane medical databases to assess epigenetic variances and their association with CAD. The Medical Subject Headings (MeSH) terms used were as follows: CAD, genetics, epigenomics, diabetes, hypertension, obesity, dyslipidemia, primary prevention, and standard of care. Further limiting the search results to Randomized Control Trials (RCT’s), meta-analysis, peer-reviewed, and published within the last 10 years. Exclusion criteria included publications before 2011, articles that did not compare genetic …

Telling The Story: Diabetes Prevention And Management, Brandi Caitlyn Frizzell

Masters Theses

Diabetes has been studied for thousands of years, however the root cause of this disease is still unknown. Although there are have been many disoveries for treatment options for this disease, there has yet to be a discovery of a cure. Diabetes is a worldwide epidemic that currently affects millions of people and is expected to affect millions more in the future. This disease often results in fatal health complications which contribute to years of life lost and mortality rates. The project proposes a solution for individuals affected by diabetes and those that are currently undiagnosed. The expected outcome of …

The Effects Of Time Restricted Feeding On Markers Of Type 2 Diabetes, Brooke Martin

Biological Sciences Undergraduate Honors Theses

Type 2 diabetes is one of the fastest growing chronic diseases in the country, comprising 10% of the American population. Obesity rates are at an all-time high and greatly increase risk factors for developing diabetes. Insulin resistance is the main feature of type 2 diabetes and causes management of the disease to be extremely difficult. Currently there are different possible treatments for type 2 diabetes including medication and dieting. However, diets involving fasting, though high in popularity, do not have a lot of evidence regarding their ability to prevent the development of type 2 diabetes.

Time restricted feeding (TRF) is …

Assessing Nutritional Health Knowledge In Sharing Clinic Patients With Diabetes, Minden Huntrods

Capstone Experience: Master of Public Health

Effective diabetes prevention and management relies on nutritional behaviors, thus a basic level of health knowledge is important for patients with diabetes and their caregivers in their quest to acquire acute glycemic control and minimize negative health outcomes (Ley et al., 2014). The purpose of this study was to assess the nutrition-related health knowledge of patients living with diabetes who are seen at the UNMC Sharing Clinic by use of a verbal questionnaire. This nutritional health knowledge assessment was a quantitative, prospective, survey-based study utilizing descriptive statistics. Approximately 86% of patients were proficient in food group and nutritious foods knowledge …