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Psilocybin Treatment For Refractory Depression: A Clinical Review, Hailey A. Jensen

The PA Department Journal of Medical Science

Introduction:

Depression is a widespread mental illness that affects a large portion of the world population and many of those who suffer from depression are resistant to treatment currently available. The purpose of this review is to compare the efficacy of psilocybin to the current available methods for the treatment of refractory depression.

Methods:

PubMed was searched with the key search terms: resistant depression, psilocybin therapy, and adults. Operators and filters narrowed down the search to 43 results. Four articles were then chosen based on quality and specificity with this review.

Results:

The articles included in this review compare the …

Psychometric Properties Of A Novel Affective Bias Task And Its Application In Clinical And Nonclinical Populations, Prathik Kalva, Kourtney Kanja, Brian A Metzger, Xiaoxu Fan, Brian Cui, Bailey Pascuzzi, John Magnotti, Madaline Mocchi, Raissa Mathura, Kelly R Bijanki

Faculty, Staff and Students Publications

To mitigate limitations in self-reported mood assessments, we introduce a novel affective bias task (ABT). The task quantifies instantaneous emotional state by leveraging the phenomenon of affective bias, in which people interpret external emotional stimuli in a manner consistent with their current emotional state. This study establishes task stability in measuring and tracking depressive symptoms in clinical and non-clinical populations. Initial assessment in a large non-clinical sample established normative ratings. Depressive symptoms were tracked relative to task performance in a non-clinical sample, as well as in a clinical cohort undergoing surgical evaluation for severe epilepsy. In both cohorts, a stronger …

Development And Validation Of The Ipip-Ocean: A Hierarchical Facet-Level Measure Of The Big Five, Caleb Niccum

Graduate Theses/Dissertations

This study focused on developing a mid-range, hierarchical, five-factor, 20-facet personality inventory (the IPIP-OCEAN) composed of 100 items drawn from both the IPIP-NEO-300 and the Abridged Big Five Circumplex. Hierarchical confirmatory factor analysis was used to validate the factor structure. Depression and anxiety, measured with the PHQ-9 and GAD-7, were used to further validate the measure through discriminant and convergent validity by examining whether the domains and facets of the IPIP-OCEAN produced findings consistent with those reported for similar scales in prior depression and anxiety research. Numerous factor analyses were conducted on the IPIP-OCEAN dataset (N = 1,058), and a …

Anti-Saccade Error Rates Are Associated With Somatic Depressive Symptoms In Cocaine Use Disorder, Constanza De Dios, Heather E Webber, Margaret C Wardle, Jin H Yoon, Michelle A Patriquin, Jessica N Vincent, Joy M Schmitz, Scott D Lane

Faculty, Staff and Student Publications

Background: Inhibitory control deficits are associated with cocaine use disorder (CUD) development and maintenance. Additionally, drug use and inhibitory control can be negatively affected by depressive symptoms, including somatic factors like sleep disturbance and fatigue.

Aim: The current study assessed the relationship between inhibitory control and depressive symptoms among individuals initiating CUD treatment. We examined associations among anti-saccade response inhibition performance, total scores on the Beck Depression Inventory-II (BDI-II), and individual BDI-II items.

Methods: N = 101 patients enrolled in a clinical trial for CUD completed drug-specific anti-saccade and depression (BDI-II) measures prior to treatment. Generalized linear models tested the …

The Kids Aren’T Alright, Amy B. Levin

Arkansas Law Review

It is not new that students struggle in law school. Research has shown for decades that, while students generally begin law school with healthy well-being, the competitive nature of law school combined with the stress of the Bar and securing post-Bar employment causes increased anxiety, depression, isolation, and related symptoms among students, especially women and underrepresented groups. What is new is the sheer number of law students struggling with serious mental health challenges today—a number that has reached crisis proportions.

This Article is divided into four parts. In Part I, I explore the mental health landscape for high school, college, …

Predictors Of Substance Use Treatment Retention: Secondary Analyses From Project Aspire, Abdulrazzaq Altararwa

The Journal of Purdue Undergraduate Research

No abstract provided.

Neuropathic Pain And Related Depression In Mice: The Effect Of A Terpene And A Minor Cannabinoid In Combination, Jose Rios, Mohammed Alnoud, Mohammad Hussain, Zayd Ayas, Emmanuel Franco, Justin D. Mills, Joshua Nwose, Maria Sophia Malbas, Hiram L. Garcia, Manish Kumar Tripathi, Khalid Benamar

School of Medicine Publications

Background/Objectives: Neuropathic pain is one of the most severe types of chronic pain. Although it is difficult to manage, it often co-occurs with depression. Yet, no medication addresses the neuropathic pain and depression comorbidity. Therefore, developing integrated treatment strategies that address both pain and depression is a major public health priority and an unmet need affecting millions. Methods: In this study, we investigated the effect of combining a terpene, Beta-Caryophyllene (BCP), and cannabidiol (CBD) on neuropathic pain and associated depression. We employed a chronic constriction injury (CCI) neuropathic pain model and a series of behavioral tests to evaluate …

Effect Of Spirituality On The Mental Health Of Adults Who Experienced Bullying In Their Childhood, Celiana Rodriguez-Gonzalez

Doctoral Dissertations and Projects

Bullying experiences in childhood have been found to significantly affect mental health in adulthood, particularly through depression and anxiety. Spirituality has been identified as a protective factor for mental health, contributing to quality of life, satisfaction, and purpose. It may also buffer the effects of violence and bullying. This correlational study examined the relationships among childhood bullying, spirituality, and adult mental health in a sample of individuals from Puerto Rico (N=124). Specifically, whether spirituality moderates the relationship between childhood bullying and adult mental health outcomes. Results indicated that childhood bullying was moderately associated with higher levels of anxiety and depression, …

Work-Life Conflict, Anxiety, And Depression In Collegiate Athletic Trainers With Children Under 5, Jordan Helton, Glenn R. Penny, Seth Swary

Student Dissertations

The research problem for this study was that collegiate athletic trainers with children under 5 years old experience significant work-life conflict and negative mental health outcomes. The purpose of this study was to explore how collegiate ATs with young children describe their experiences of work-life conflict and to how these experiences relate to symptoms of anxiety and depression. Guided by interrole conflict theory and work-life conflict theory the study posed two research questions: (1) How do collegiate ATs with children under 5 describe their experiences of work-life conflict? (2) What is the relationship work-life conflict experiences on the symptoms …

Pathways To Better Sleep, Mairead E. Moloney, Emily Slade, Joon Chung, Kory Heier, Daniela C. Moga

Sociology Faculty Publications

Background: Rural Appalachia has some the highest rates of sleep and health disparities in the United States. This study investigates the relationship between social support and insomnia severity in rural Appalachian adults, with specific attention to the potential mediating roles of depression, anxiety, and stress. Methods: Participants from 12 rural Eastern Kentucky counties completed validated measures of insomnia severity, social support, depression, anxiety, and perceived stress. Using R, we calculated descriptive statistics and fit mediation models for depressive symptoms, anxiety symptoms, and stress, with social support as the exposure and insomnia severity as the outcome. Results: Aligning with regional demographics, …

Transdiagnostic Links Of Reward Processing In Obsessive-Compulsive Disorder And Depression, Kevin M Wagner, Matti Cervin, Jessica S C Cheng, Jasmine Arriaga, Vanessa Zavala Cruz, Dayan Berrones, Josselyn S Muñoz, Renee M Frederick, Jacey L Anderberg, Belinda E Núñez Bracho, Victor R Adorno, Leonardo F Fontenelle, Andrew D Wiese, Latin American Trans-Ancestry Initiative For Ocd Genomics (Latino), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (Gttoc), James J Crowley, Eric A Storch

Faculty, Staff and Students Publications

Objectives: Transdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in individuals with OCD and (2) explore how each domain is uniquely associated with OCD and depression.

Methods: A total of 1345 individuals with a history of OCD symptoms (ages 18-88, 71 % women) from Latino communities in the United States (including Puerto Rico) and nine Latin American countries completed validated …

Basic Effectiveness Of Group Mindfulness-Based Cognitive Therapy (Gmbct) In The University Setting, John Robert C. Rilveria, Nisseth Clarize S. Carido, April Veronica G. Lansangan, Alaya Gabrielle N. Villaflor, Anna Cristina A. Tuazon, Divine Love A. Salvador, Violeta V. Bautista

Asia-Pacific Social Science Review

The COVID-19 pandemic has reshaped daily life and amplified mental health challenges worldwide, with university students identified as a particularly vulnerable group. To address this need, the present study evaluated the effectiveness of group mindfulness-based cognitive therapy (GMBCT) as an evidence-based intervention for students receiving psychosocial services during the pandemic. Using a pretest–posttest design, data from 34 students randomly assigned to either GMBCT or individual treatment-as-usual (TAU) provided by a university-based clinic were analyzed. To evaluate treatment effects, an analysis of covariance (ANCOVA) was conducted to compare post-treatment outcomes between the two groups while controlling for pre-treatment scores, treatment length, …

Oral Ketamine For Treatment Resistant Depression: A Literature Review, Maeve Buni, Alanna Eisenbeiser

Physician Assistant Capstones, 2020-current

Objective: Assess the efficacy and safety of oral ketamine as alternative therapy for those with treatment resistant depression (TRD). Design: Literature review. Methods: On November 14, 2024, a search was done in Pubmed and James Madison University’s EBSCO Psychology and Behavioral Sciences Collection for the terms “ketamine” and “treatment resistant depression,” excluding parenteral routes of administration and including only randomized controlled trials in adults published in 2018-2024. Results: Three randomized controlled trials that utilized evidence-based surveys to assess antidepressant effects were analyzed. Conclusion: The antidepressant effects of oral ketamine found in these RCTs were somewhat mixed. Oral ketamine did appear …

Is Hormonal Contraceptive Use Associated With An Increased Incidence Of Depression?, Natalie Montesano, Virginia H. Billings

Physician Assistant Capstones, 2020-current

Objective: To investigate the proposed positive association between hormonal contraception (HC) use and depression incidence. Design: Literature review. Method: A search across CINAHL Plus with Full Text and PsycInfo databases was conducted to find three prospective cohort studies with a focus on HC use and depression which were evaluated individually and collectively. Results: Three studies were found that met search criteria: de Wit et al., Johansson T et al., Skovlund et al. Conclusion: All studies found a positive association between depression in adolescent HC users while only two of the three (Skovlund et al., Johansson T et al.) found this …

Psychiatric Comorbidities And Treatment Modalities In Children With Osteogenesis Imperfecta: A Systematic Review Of Mental Health, Julia M Morales, Camille F Villar, Beatriz Varman, Gianna M Colombo, Danqi Li, Sarah J Sadek, Marie-Eve Robinson, Chaya N Murali, Kara Ayers, Jocelyn Gomez, Brendan Lee, V Reid Sutton, Eric A Storch, Andrew D Wiese

Library Staff Publications

To evaluate the prevalence of psychiatric signs and symptoms and describe psychotherapeutic and psychopharmacological interventions among children with osteogenesis imperfecta (OI). PRISMA guidelines were followed, and the study was registered in PROSPERO (CRD42024588284). Studies (n = 1419) were identified across five databases. Eligible studies, identified by independent reviewers, included peer-reviewed research on psychiatric comorbidities or interventions in children with OI. Data extraction included study design, population characteristics, mental health outcomes, and treatment effectiveness, with all studies assessed for quality and bias. Findings were synthesized to evaluate the prevalence of psychiatric comorbidities and intervention effectiveness. Five articles met inclusion criteria after …

The Association Between Loneliness And Mental Health In Underserved Communities, Ameemah Khan, Yu-Ping Chang

Biennial Convention (CONV)

Background: Loneliness is a distressing emotional state that arises when an individual's actual social relationships do not align with their desired social connections. As loneliness becomes increasingly prevalent among adults, its adverse effects on mental health have grown more evident. Research links loneliness to poor sleep quality, suicidal ideation, severe depressive symptoms, and heightened stress. These effects are particularly pronounced in underserved communities, where social determinants of health disproportionately impact African Americans, contributing to poorer health outcomes. However, limited research explores the relationship between loneliness, sleep, and depression specifically within African American populations.

Purpose: This study aims to determine whether …

Treatment Concerning Grief Disorder After Covid-19: Can Spiritual Care Help?, Tamika Marie Johnson

Doctoral Dissertations and Projects

The phenomenological study described the experiences of spiritual care for adults who lost a loved one due to COVID-19 in Texas. The theory guiding the study was Viktor Frankl’s logotherapy, which was humanity’s search for meaning in a finite world governed by spiritual principles (García-Alandete, 2024; Parker, 2022; Seligman & Reichenberg, 2014). Grief was one of the occurrences that grappled with humanity’s understanding of life. Death was a universal phenomenon, and grief occurred as a response to a loss (Fernández & González-González, 2022). Research shows that symptoms of grief dissipate over time. When it was accompanied by prolonged time or …

Psychological Variables That Best Predict Health Related Behaviors In College Students, Arianna Gamaggio

Honors Theses

The present study examined which psychological factors best predicted health behaviors in college students. The psychological factors that were addressed included anxiety, depression, grit, and psychological flexibility. The health behaviors were examined by using a composite variable that included sleep, diet, and exercise. A total of 265 students participated in the study, but only 174 (μ age = 21) met the criteria for inclusion. Participants completed validated self-report measures such as the GAD- 7 (anxiety), PHQ-9 (depression), Short Grit Scale, Psy-Flex-6 (psychological flexibility), as well as health behavior assessments that measured eating behaviors, sleeping, and exercise habits. Correlational analyses indicated …

Cognitive Behavioral Therapy: The Relationship Between Diet, Anxiety, And Depression And The Moderating Effect Of Cbt, Deborah J. Wright

Doctoral Dissertations and Projects

This study examined how cognitive behavioral therapy (CBT) techniques including cognitive restructuring and positive affirmations affect the relationship between dietary patterns and depression and anxiety symptoms. Research has established that CBT and diet affect depression and anxiety independently, but less research examines their collective impact. The study included 154 adult participants who filled out the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7 alongside a Dietary Habits Checklist and a CBT Engagement Checklist during the previous two weeks. The results from multiple linear regressions showed no statistically significant moderation effects of CBT engagement on the relationship between diet and depression …

Temporal Associations Between Social Media Use Frequency And Social Media Addiction And Depressive, Anxiety, And Insomnia Symptoms Among Hispanic Emerging Adults: Moderation By Identity Exploration And Instability And Negativity, Miguel Andres Garcia

Open Access Theses & Dissertations

The number of social media users has drastically increased in recent years, and rates of social media use are particularly pronounced among emerging adults and Hispanic groups. Furthermore, emerging adults are at risk for poor mental health and report poor sleep health, and Hispanic groups may experience sleep disparities compared to their non-Hispanic White counterparts. Although many studies have assessed the associations between social media use frequency and social media addiction and depressive, anxiety, and insomnia symptoms, fewer have investigated these associations prospectively. Similarly, few studies have assessed potential moderators of these associations. Thus, the current study investigated the temporal …

Analyzing The Hidden Impact Of Work Stress On Mental Health, Shaikha Aljabry

Theses

Occupational stress and deteriorating mental health constitute an increasing issue in the global community, and the problem of how job demands, personal resources, and cognitive processes interrelate to determine employee well-being is hardly known. This dissertation will study these dynamics by incorporating theory-driven Structural Equation Modeling (SEM) with data-driven Machine Learning (ML) methods that offer explanatory and predictive information. The study examines the influences of job demands, personal resources, effort–reward imbalance (ERI), emotional labor, cognitive appraisal, and social support on the stress and mental health outcomes of a sample of 5,000 employees working in various industries and regions of the …

Exercise As A Treatment For Depression And Anxiety Symptoms In College Students, Ashley J. Fountain

ATU Honors Projects

Anxiety and depression have become increasingly prevalent among college students, with rates rising to levels that demand urgent and accessible treatment alternatives. Traditional interventions such as psychotherapy and pharmacological treatments, while effective for many, present limitations including high cost, side effects, and barriers to access. This paper examines exercise as a holistic, evidence-based treatment modality for reducing symptoms of depression and anxiety in college students. Recent research demonstrates that aerobic exercise, resistance training, and yoga each produce meaningful physiological and psychological benefits through mechanisms involving neurotransmitter regulation, reduced cortisol levels, and enhanced self-esteem. Studies comparing exercise with antidepressant medications show …

Associations Between School Experiences And Mental Health Outcomes By Gender Identity In Sexual And Gender Minority Youth In Texas And California, 2022 - 2024, Andrea Susana Yanez

Open Access Theses & Dissertations

Background: Depression and anxiety affect populations differently, with diagnoses disproportionately higher among sexual and gender minority groups, including LGBTQ+ youth. School experiences shape mental health; negative environments, bullying, and lack of support worsen outcomes, while affirming policies, peer support, and inclusive curricula are protective. Methods: This secondary analysis of the Family, Housing, and Me (FHAM) Project followed 83 LGBTQ+ youth from South Texas and California's Inland Empire (2022-2024). Data on sociodemographic characteristics, school experiences, and mental health outcomes were collected at baseline and at Waves I and II over 25 months. Analyses included descriptive statistics, monthly comparisons, and bivariate and …

Elucidating Neurocognitive Mechanisms Underlying Depression-Related Differences In Executive Control Under Stress, Benjamin Swanson

Graduate Theses and Dissertations

Executive control under stress has been shown to be a robust predictor of psychopathology, especially Major Depressive Disorder (i.e., depression). However, the underlying neural mechanisms that might explain this association have not been examined. To address this gap, both controls (n = 30) and individuals with current or past depression (n = 30) completed a modified Stroop task under fMRI. Behaviorally, we assessed both participants’ executive control performance and their subjective affect during the task. At the neural level, we examined brain regions related to both executive-related control (e.g., DLPFC) and executive-related affective processes (e.g., amygdala, striatum), as well as …

Social Support And Depression In Latinx Youth: A Meta-Analysis, Dulce Diaz Benitez

Graduate Theses and Dissertations

Although previous meta-analyses have found significant relationships between social support and youth outcomes, neither has included ethnicity as a moderator or even described the ethnic breakdown in the studies analyzed (Chu et al., 2010; Rueger et al., 2016). Studies that have looked at the relationship between social support and outcomes in Latinx youth have found mixed findings. This study examined the relationship between social support and depression in Latinx youth living in the United States. This study also explored differences in the strength of the relationship between social support and depression in several previously studied moderators (function of social support, …

Quality Improvement Project: The Impact Of Staff Education On Utilization Of The Phq-9 Tool And Follow-Up Management Protocol, Shuntak Jerideau

Doctor of Nursing Practice Projects

Depression is a prevalent mental health disorder that affects daily functioning. Timely screening enables the identification of symptoms, monitoring treatment efficacy, and informs additional treatment such as referrals. The practice site reported low screening rates of patient’s post-psychiatric hospitalization, which was attributed to inadequate knowledge of the PHQ-9 tool. The purpose of this quality improvement project was to evaluate the impact of staff education on the utilization of the PHQ-9 tool and follow-up management protocol in a mental health clinic. A quasi-experimental design method was used in an outpatient mental health clinic. Pretest knowledge of the PHQ-9 was obtained from …

Antidepressant Use In Older Age Bipolar Disorder (Oabd): Results From The Gage-Bd International Consortium, P. J. Chen, Lisa T. Eyler

Faculty Scholarship

Background Antidepressants are still commonly prescribed in bipolar disorders, despite ongoing controversy of the potential risk of inducing hypomania/mania. There is limited knowledge about the characteristics of antidepressant use in older age bipolar disorder (OABD; age ≥50) in the current literature. Aim To describe antidepressant use, sociodemographic and clinical correlates of a global sample of OABD individuals. Methods The Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) consortium provided cross-sectional international data on OABD individuals ( n = 746) and younger-age bipolar disorder (YABD, age <50 years; n = 692) regarding antidepressant use. Multivariate logistic regression was employed to assess the association between AD use with demographic and clinical variables. Results Of 1252 participants, 33.1 % of OABD individuals and 38.1 % of YABD individuals were using antidepressants. In multivariable models among OABD, antidepressant use was associated with BD type II (OR = 1.61, 95 % CI: 1.09–2.38), higher depression severity (mild-to-moderate: OR = 1.86, 95 % CI: 1.13–3.06; severe: OR = 4.23, 95 % CI: 2.38–7.50), lower YMRS scores (OR = 0.93, 95 % CI: 0.89–0.97), female sex (OR = 1.37, 95 % CI: 1.00–1.89), lower education (OR = 0.61, 95 % CI: 0.43–0.86), and being unemployed (OR = 0.69, 95 % CI: 0.50–0.96). Antidepressant monotherapy was reported in 18 % of OABD users ( n = 46) and 19 % of YABD users ( n = 51). These findings suggest that both clinical severity and sociodemographic characteristics influence antidepressant prescribing in OABD. Conclusion Antidepressant use was less prevalent in OABD compared to YABD, and associated with female sex, lower education, lack of occupation, type II BD, higher depression severity and lower mania scores. In OABD, antidepressants appear to be used more commonly in contexts where they may be clinically more indicated, such as increased depression severity.

Exploring The Acceptability Of The Kimberley Mum’S Mood Scale For Perinatal Mental Health Screening In Gove District Hospital, North-East Arnhem Land, Tom P. Atkinson, Erica P. Spry, David Atkinson, Julia V. Marley, Emma Carlin

Journal of the Australian Indigenous HealthInfoNet

Objective: Across Australia perinatal mental health challenges disproportionately impact Aboriginal women. Identifying Aboriginal women at risk of adverse mental health outcomes in the perinatal period is an important step in supporting their overall health and wellness. Current screening tools have significant limitations when used with Aboriginal women.

The Kimberley Mums Mood Scale (KMMS) is a culturally secure approach to screening for perinatal mental health disorders in Aboriginal women. It has been validated in the Kimberley region of Western Australia and may be able to improve mental health screening in other regions. In this study the KMMS was trialled at a …

Incorporating Behavioral Health Strategies In Primary Care To Improve Outcomes Of Depressed Patients, Amy L. Brummett

Student Scholarly Projects

Practice Problem: Depression, otherwise known as major depressive disorder, is a mood disorder characterized by persistent feelings of sadness, loss of interest, sleep disturbances, changes to weight (both gain and loss), difficulty concentrating, and in extreme cases, suicidal thoughts, and/or attempts (Mayo Clinic, 2022). An estimated 8.3% or 21.0 million adults in the United States have experienced at least one episode of depression. Primary care clinicians are often the first to recognize the symptoms of depression. Depression was very prevalent in the clinic where this DNP Scholarly project took place. The owner/nurse practitioner found that she was increasingly treating depressed …

Psychological Impact Of Pulmonary Embolism: A Narrative Review., Farooq Hyder, Hina Pervaiz, Fnu Karishma, Daya Kumari, Poonam Kumari, Ali Karim, Hari Vishal Nenwani, Allah Warayo, Kishor Kumari, Muhammad Salman, Abida Parveen, Mubeena Javid, Raveena Bai Bansari

Journal of Community Hospital Internal Medicine Perspectives

Background: Pulmonary embolism (PE) is a potentially life-threatening thromboembolic condition that demands urgent medical attention. While significant strides have been made in the diagnosis, treatment, and prevention of PE, its long-term psychological consequences remain underexplored. Survivors often face considerable emotional and psychological challenges that can impair recovery and reduce quality of life. This narrative review aims to explore the psychological impact of PE, including common mental health outcomes such as anxiety, depression, post-traumatic stress disorder (PTSD), and health-related fears. It also examines contributing factors such as persistent physical symptoms, anticoagulation therapy, social and occupational disruptions, and gaps in mental health …