Digital Commons Network^™

A Novel Class Of Tmprss2 Inhibitors Potently Block Sars-Cov-2 And Mers-Cov Viral Entry And Protect Human Epithelial Lung Cells, Matthew Mahoney, Vishnu C Damalanka, Michael A Tartell, Anne E Mayer Bridwell, Jorine Voss, Partha Karmakar, Paul W Rothlauf, Cassandra E Thompson, Christina L Stallings, Sean P J Whelan, James W Janetka, Et Al

Open Access Publications

The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This protease activates the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and of other coronaviruses and is essential for viral spread in the lung. Utilizing rational structure-based drug design (SBDD) coupled to substrate specificity screening of TMPRSS2, we have discovered covalent small-molecule ketobenzothiazole (kbt) TMPRSS2 inhibitors which are structurally distinct from and have significantly improved activity over the existing known inhibitors Camostat and Nafamostat. Lead compound MM3122 (4) has an IC

American Society Of Hematology Living Guidelines On The Use Of Anticoagulation For Thromboprophylaxis In Patients With Covid-19: May 2021 Update On The Use Of Intermediate-Intensity Anticoagulation In Critically Ill Patients, Adam Cuker, Kristen M Sanfilippo, Et Al

Open Access Publications

BACKGROUND: COVID-19-related critical illness is associated with an increased risk of venous thromboembolism (VTE).

OBJECTIVE: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in making decisions about the use of anticoagulation for thromboprophylaxis in patients with COVID-19-related critical illness who do not have confirmed or suspected VTE.

METHODS: ASH formed a multidisciplinary guideline panel that included 3 patient representatives and applied strategies to minimize potential bias from conflicts of interest. The McMaster University Grading of Recommendations Assessment, Development and Evaluation (GRADE) Centre supported the guideline development process …

Neutralizing Monoclonal Antibodies That Target The Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection Against Sars-Cov-2 Infection In Syrian Hamsters, Wen Su, Sin Fun Sia, Aaron J Schmitz, Traci L Bricker, Tyler N Starr, Allison J Greaney, Jackson S Turner, Bassem M Mohammed, Zhuoming Liu, Ka Tim Choy, Tamarand L Darling, Astha Joshi, Ka Man Cheng, Alvina Y L Wong, Houda H Harastani, John M Nicholls, Sean P J Whelan, Jesse D Bloom, Hui-Ling Yen, Ali H Ellebedy, Adrianus C M Boon

Open Access Publications

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-phase sera or monoclonal antibodies (MAbs). Potently neutralizing antibodies are expected to confer protection; however, it is unclear whether weakly neutralizing antibodies contribute to protection. Also, their mechanism of action

Covid-19 Experiences, Behaviors, Beliefs, And Well-Being Among Students And Employees At A University In Rural Appalachia: A Cross-Sectional Study, Lauren Wisnieski, Kimberly A. Carney, Jenny L. Thornley

Journal of Appalachian Health

Introduction: In response to the coronavirus disease (COVID-19) pandemic, most universities experienced drastic operational changes with shifts to online learning, work-from-home policies, and social distancing measures. These changes have caused concern for social isolation and mental health.

Purpose: This cross-sectional study explores differences in COVID-19 experiences, behaviors, beliefs, and well-being among students and employees (faculty and staff) at a rural Appalachian university.

Methods: Data were collected with an online anonymous survey in September-October 2020 using convenience sampling. The survey measured multiple domains including COVID-19-related 1) beliefs, 2) symptoms and diagnoses, 3) exposure and preventive behavior, and 4) social, mental, and …

The Compounding Effect Of Rurality On Health Disparities Among Black Patients With Covid-19, Jessica E. Johnson, Ruchi Bhandari, Allison Lastinger, Rebecca Reece

Journal of Appalachian Health

Background: West Virginia had garnered national attention for its vaccination rollout against coronavirus 2019 (COVID-19). Outcomes of this mostly rural population, however, have been underreported. As the pandemic continues, identifying high risk populations remains important to further epidemiologic information and target vaccines.

Purpose: The objective of this study is to examine the effects of COVID-19 and the influence of race and rurality on hospitalization and outcomes in Appalachians.

Methods: In this retrospective study, data from patients who tested positive and were admitted for COVID-19 and seen within the state’s largest health system (West Virginia University Health System) between March …

Taking Flight: Giving Up The Things That Weigh Me Down, Karina Malik

Occasional Paper Series

From the perspective of a Latinx, dual-language, special education, public school teacher, I explore and detail what an equitable and just education could look like in our future. I begin by envisioning a future that:

• Values collaboration in teaching and learning

• Allows for spaces of ongoing teacher learning where we teachers decide where we want to grow and how we want to learn.

• Invests in our growth and development as educators.

• Consists of a solid understanding that there is more expertise across communities than in any one person.

I continue by explaining that in order for this to be a …

Shifting Skins: Becoming Multiple During Emergency Online Teaching, Bianca Licata, Catherine Cheng Stahl

Occasional Paper Series

In this essay, we reflect on the emergence of our (new) teacher identities from the phenomenal space created within online learning, following the COVID-19 pandemic of 2020. Thrust from classrooms into in-between spaces mediated by digital technologies, the capricious co-inhabited new learning space functioned as a becoming-other space of identity-play, surfacing from centrifugal intra-actions among human, non-human, and inorganic entities and energies—what we have named a thinning space (authors, forthcoming). It called for becoming shapeshifters together through resisting crystallized roles and (re)claiming a multiplicity of vulnerable thin skins. We draw from the possibilities of existing virtual gaming spaces to …

2021-10-25_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2021-10-25_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

Five Things You Should Know This Week, Georgia Southern University

A Few Things You Should Know This Week (2020-2023)

• 1. Homecoming events start this week
• 2. This is the last week for $50 vaccine incentives and to sign up for a $1,000 vaccine reward
• 3. Moderna and Pfizer booster doses for qualifying individuals are available for scheduling in the MyGS portal
• 4. J&J booster shots are recommended
• 5. Open House Thursday at Discovery Center on Armstrong Campus in Savannah

Covid-19 Exposures And Health Alerts (10/18/2021- 10/24/2021), Georgia Southern University

Covid-19 Pandemic: News & Publications (Archived)

The report below shows an anticipated rise in confirmed and self-reported cases after completion of the second full week of classes on our campuses. As an institution of nearly 27,000 students and 3,350 employees, positive reports represent a very small proportion of our overall university population. These cases are primarily concentrated within the student population on the Statesboro campus. While we have been pleased with how the university community is complying with public health guidelines on our campuses, we must remain vigilant in our efforts if we want to continue the semester as we have started.

Online Adjunct Faculty Perceptions Of Professional Development To Support Personal And Professional Academic Growth During Covid-19, Cheryl Burleigh, Patricia B. Steele, Grace Gwitira

Higher Learning Research Communications

Objective: The purpose of this study was to understand what online adjunct faculty value as support services, specifically professional development opportunities, provided by their respective higher education institutions.

Method: This qualitative narrative inquiry study centered on exploring perceptions and experiences of online adjunct faculty members from higher education institutions and their experiences and expectations of professional development (PD), prior to and during COVID-19.

Results: The study resulted in the identification of possible improvements and enhancements to existing PD content that would further support faculty personal development, mental health, wellbeing, and academic growth.

Conclusions: This study reminds us that there are …

2021-10-24_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Social Media, Populism, And Covid-19: Weibo Users’ Reactions To Anti-Chinese Discourse, Theresa Catalano, Peiwen Wang

Department of Teaching, Learning, and Teacher Education: Faculty Publications

US government communication about the COVID-19 pandemic, particularly the ‘Chinese virus’ discourse adopted by Donald Trump and his administration, has led to real-world violence and triggered heated discussions across social media sites, including Sina Weibo (aka Chinese Twitter). The current study explores the relationship between populism and social media by examining how Sina Weibo users respond to Trump’s communication on the virus. Employing multimodal critical discourse analysis, we examine both visual and verbal strategies used to build counter-discourses that challenge the use of terms such as ‘Chinese virus’. Findings demonstrate the potential of Weibo as a platform of resistance and …

Unh President Announces Vaccine Mandate For All Unh Employees, Ben Mackillop

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Ocular Characteristics Of Non-Covid-19 Patients: A Retrospective Study Of Time-Sensitive Ophthalmic Care During The Pandemic, Yun-Ping Moore Od, Laura Ward Msph, Farah Gulaid Od, Susan A. Primo Od, Mph

Optometric Clinical Practice

Purpose: To analyze the cohort of clinical patients seen during the COVID-19 pandemic shutdown at Emory Eye Center in comparison with prior weeks.

Method: We conducted a retrospective chart review from three outpatient clinical sites over a period of eighteen weeks, which covered pre-COVID-19 dates as well as the dates of when our clinics were closed near the beginning of the COVID-19 pandemic. We utilized data from providers assigned to daily triage coverage for in-person exams. Primary diagnosis and visit type data were extracted to look for trends and commonalities among urgent or time-sensitive patients.

Results: For the nine weeks …

Faith Community Nurses: Caring For Individuals, Congregations, And Communities During The Covid-19 Pandemic, Mary Lynne Knighten Dnp, Rn, Nea-Bc, Lorie Hacker, Phyllis Ann Solari-Twadell, Lanet Owen Bsn, Rn-Bc, Bob Kentner Dnp, Rn, Chpq, Cen, Tcrn, Linda F. Garner

International Journal of Faith Community Nursing

As the COVID-19 pandemic continues for nearly two years, communities of faith are struggling to meet the spiritual needs of individuals, congregants, and communities during a particularly trying time in history. They have experienced closures, phased re-openings, and reinstated restrictions as the pandemic sees the fourth surge and a deadly more transmissible form of COVID in the Delta Variant. Faith Community Nurses, who are specially educated to provide intentional care of the spirit, play a pivotal role in providing care, support, and education to maintain and improve whole person health when people are isolated, physically distant, and at times critically …

Impacting Community Well-Being In Lafayette, Indiana, In The Midst Of A Pandemic, Eli Coltin, Eric Flaningam, Jace Newell, Jason Ware

Purdue Journal of Service-Learning and International Engagement

For the past five years, Dr. Jason Ware has centered community-based research and service-learning courses around local community partners’ needs as they focused collectively on community well-being issues. The nature of their work has prioritized qualitative research methods such as narrative inquiry via in-depth interviews and ethnography via immersive observations within varying service-providing institutions such as the Hartford Hub and the Hanna Community Center. COVID-19 and the constant threat of its transmission meant that Dr. Ware, his students, and their community partners had to approach their work differently. They responded with a pivot. They turned to mining large publicly accessible …

Homelessness And Covid-19, Justin Macneill, Alexa Lahey, Nina Teo

Purdue Journal of Service-Learning and International Engagement

The COVID-19 pandemic has exacerbated the struggle of people experiencing homelessness (PEH) and presented new challenges to those serving this vulnerable population. To better understand and articulate how COVID has impacted both PEH and their ecosystem of support, we compared the national response - aggregated via a literature review of both gray and academic literature - to the statewide response in Indiana and the local response in Tippecanoe County.

Local homelessness providers emphasized that organizational partnerships are key - policy changes in one organization can have malignant effect extending throughout and putting additional strain on other organizations within the local …

Student Pharmacists’ Response To A Pandemic: Service-Learning Through Contact Tracing, Antoinette Martin, William Harris, Alexander Szu-Wei Chao, Caroline Blankemeier, Diane Hobbs, Emily Hall, Emily Harvath, Madilyn Eberle, Monica L. Miller, Rakhi Karwa

Purdue Journal of Service-Learning and International Engagement

In March 2020, the SARS-CoV-2 (COVID-19) pandemic disrupted education nationwide. To safely deliver in-person classes, Purdue University contracted One-to-One Health, creating the Protect Purdue Health Center (PPHC). The PPHC was a central location for information, testing, and case management for Purdue students, staff, faculty and their dependents. Contact tracing is a proven public health measure that has been utilized to control the spread of infectious diseases by identifying and isolating potential active cases. The communicative nature of contact tracing, along with its need for clinical decision-making skills makes the student pharmacist an ideal candidate for aiding in this pandemic response. …

A Community Health Initiative: Health To The Power Of You, Stephanie Hendricks

Purdue Journal of Service-Learning and International Engagement

In April 2020, the COVID-19 pandemic impacted the number of visits to ambulatory care practices and was reported to have declined by nearly 60%. The extent of this decline is alarming as outpatient visits help manage chronic diseases in patients, such as diabetes, high blood pressure, and high cholesterol. This trend sparked an interest in pharmacist and student pharmacist, Dr. Cynthia Koh-Knox Sharp and Stephanie Hendricks, respectively, as it offered an opportunity to help serve the Greater Lafayette community. We created Health to the Power of You (Health^You), which targets two of Lafayette’s neglected populations: community members experiencing …

Adapting Global Service-Learning Project And Community Partnership Outcomes Using A “Tele-Engineering” Approach In Response To The Covid-19 Pandemic, Christiane Ley, Danielle Angert, Tessa Hudelson, Jordan Harris

Purdue Journal of Service-Learning and International Engagement

The Water Supply in Developing Countries (WSDC) service-learning course at Purdue University has fostered a strong partnership with the La Vega region in the Dominican Republic since 2012. During this time, an interdisciplinary group of engineering and science students has helped design drinking water treatment systems and the group has developed water, sanitation, and health (WASH) education materials. These WASH education and water safety approaches often have been conducted in person in the past. However, with the state of the COVID-19 pandemic and the inability to travel in the fall and spring semesters of the 2020–2021 academic year, the students …

Exposure To Social Media Racial Discrimination And Mental Health Among Adolescents Of Color, Xiangyu Tao, Celia B. Fisher

Covid-19 Digital Research

Offline and online racial discrimination has been associated with mental health problems among adolescents of color. Pandemic shelter-at-home policies and the reignited racial justice movement increased the use of social media among youth of color, potentially exposing them to social media racial discrimination. Yet, it is unclear which aspects of social media significantly contributed to youth exposure to racial discrimination and associated mental health issues during this period. This study assessed the relationships among social media use (hours, racial intergroup contact, and racial justice civic engagement), individual and vicarious social media discrimination (defined as personally directed versus observing discrimination directed …

The Ot/Ota Student Response To Covid-19: A Cross-Sectional Survey Of Occupational Therapy Student Roles During Crisis Management, Frances Calingo, Msot, Olivia Biller, Tina Deangelis, Edd, Ms, Otr/L

Department of Occupational Therapy Posters and Presentations

This exploratory cross-sectional survey study sought to understand OT/OTA student use of time and/or volunteerism efforts as a result of immediate and unexpected role changes brought on by COVID-19 as students were required to abruptly transition from in-person to virtual learning in every program in the United States (American Occupational Therapy Association [AOTA], 2020a).

2021-10-22_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

2021-10-22_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Delivered, Delivery Trend, Primary Series Doses Administered, Primary Series Doses by Vaccine, Primary Series Doses Metrics, Additional/Booster, Coverage, …

2021-10-22_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

2021-10-22_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Effectiveness Of Pfizer-Biontech Mrna Vaccination Against Covid-19 Hospitalization Among Persons Aged 12-18 Years - United States, June-September 2021., Samantha M. Olson, Margaret M. Newhams, Natasha B. Halasa, Ashley M. Price, Julie A. Boom, Leila C. Sahni, Katherine Irby, Tracie C. Walker, Stephanie P. Schwartz, Pia S. Pannaraj, Aline B. Maddux, Tamara T. Bradford, Ryan A. Nofziger, Benjamin J. Boutselis, Melissa L. Cullimore, Elizabeth H. Mack, Jennifer E. Schuster, Shira J. Gertz, Natalie Z. Cvijanovich, Michele Kong, Melissa A. Cameron, Mary A. Staat, Emily R. Levy, Brandon M. Chatani, Kathleen Chiotos, Laura D. Zambrano, Angela P. Campbell, Manish M. Patel, Adrienne G. Randolph, Overcoming Covid-19 Investigators

Manuscripts, Articles, Book Chapters and Other Papers

Pfizer-BioNTech COVID-19 vaccine is authorized for use in children and adolescents aged 12-15 years and is licensed by the Food and Drug Administration (FDA) for persons aged ≥16 (1). A randomized placebo-controlled trial demonstrated an efficacy of 100% (95% confidence interval [CI] = 75.3%-100%) in preventing outpatient COVID-19 in persons aged 12-15 years (2); however, data among adolescents on vaccine effectiveness (VE) against COVID-19 in real-world settings are limited, especially among hospitalized patients. In early September 2021, U.S. pediatric COVID-19 hospitalizations reached the highest level during the pandemic (3,4). In a test-negative, case-control study at 19 pediatric hospitals in 16 …

Public Awareness And Support For Use Of Wastewater For Sars-Cov-2 Monitoring: A Community Survey In Louisville, Kentucky., Rochelle H. Holm, J. Michael Brick, Alok R. Amraotkar, Joy L. Hart, Anish Mukherjee, Jacob Zeigler, Adrienne M. Bushau-Sprinkle, Lauren B. Anderson, Kandi L. Walker, Daymond Talley, Rachel J. Keith, Shesh N. Rai, Kenneth E. Palmer, Aruni Bhatnagar, Ted Smith

Faculty and Staff Scholarship

The majority of sewer systems in the United States and other countries, are operated by public utilities. In the absence of any regulation, public perception of monitoring wastewater for population health biomarkers is an important consideration for a public utility commission when allocating resources for this purpose. In August 2021, we conducted a survey as part of an ongoing COVID-19 community prevalence study in Louisville/Jefferson County, KY. The survey comprised of seven questions about awareness of and privacy concerns and was sent to 32,000 households randomly distributed within the county. A total of 1,220 sampled adults participated in the probability …