Digital Commons Network^™

Diagnosing Covid-19 Infection In Chest X-Ray Images Using Neural Network, Salim M. Zaki, Mustafa Musa Jaber, Mohammed A. Kashmoola

Baghdad Science Journal

With its rapid spread, the coronavirus infection shocked the world and had a huge effect on billions of peoples' lives. The problem is to find a safe method to diagnose the infections with fewer casualties. It has been shown that X-Ray images are an important method for the identification, quantification, and monitoring of diseases. Deep learning algorithms can be utilized to help analyze potentially huge numbers of X-Ray examinations. This research conducted a retrospective multi-test analysis system to detect suspicious COVID-19 performance, and use of chest X-Ray features to assess the progress of the illness in each patient, resulting in …

Covid-19 Vaccine Equity: Codesigning Public Health Interventions With Community Partners, Eva Varotsis, Lauren Schlegel, B. H. Slovis, Patricia C. Henwood, Sandra E Brooks, Robert S. Pugliese, Bon Ku, Morgan Hutchinson

Department of Emergency Medicine Faculty Papers

No abstract provided.

Influence Evaluation On Near-Road Concentrations Of Pm2.5 During Covid-19 Pandemic, Marcos Alan Banda Morales

Open Access Theses & Dissertations

SARS-CoV-2, also known as COVID-19, was discovered in Wuhan, China in late 2019and spread rapidly worldwide in 2020. The COVID-19 pandemic and its quarantine periods influenced the number of people using their vehicles and the number of miles traveled, which correspondingly influenced the air quality of urban areas. The influence of the restrictions caused by the quarantine period on air quality differs from location to location. Previous research accounted for countries, but no research was done at the state level individually. This research attempts to evaluate the transportation-related air quality during the COVID-19 pandemic period using data from the Texas …

A Correlative Study Of K-12 Teacher Technology Acceptance In A Post Covid-19 World: Determinants Of Behavioral Intention, Maria Ing

Theses and Dissertations

The shift to emergency remote teaching due to the COVID-19 pandemic in the spring of 2020 forced educators across the globe to heavily rely on technology for the continuity of teaching and learning. As educators return to face-to-face instruction with increased access and expectations to implement technology in their classrooms, it is important to evaluate factors that impact teachers’ acceptance of technology. The Unified Theory of Technology Acceptance (UTAUT) provides an instrument that can be utilized to measure factors that may determine teacher behavioral intention to integrate technology into their classrooms. In this quantitative survey research, K-12 teachers …

Special Education Teachers’ Self-Efficacy During The Times Of A Global Pandemic, Vanessa G. Leal

Theses and Dissertations

This quantitative dissertation aims to describe and compare the perception of special education teachers' self-efficacy amid the COVID-19 pandemic using the practice of distance and their self-efficacy pre-pandemic using face-to-face instruction and describe the perceived valuable supports teachers received from educational leaders during the pandemic and considered valuable. The study population includes special education teachers teaching in inclusive settings before and during the pandemic in grades 6–12 in districts located in South Texas. The current study's data was analyzed using a two-way factorial analysis of variance, with both factors including repeated measures within subjects (2 x 3). A descriptive statistical …

Measuring Macroeconomic Shocks Of The Covid-19 Pandemic: An Empirical Analysis For Bhutan, Lekey Dorji

Theses

Taking GDP growth and inflation as endogenous variables, this paper employs a Structural VAR from Baumeister and Hamilton (2015, 2019) to identify aggregate demand and aggregate supply shocks for Bhutan, focusing on the COVID-19 pandemic. The results suggest that 94 percent of the GDP growth plunge in 2020 is attributable to a fall in aggregate supply. The higher inflation during the COVID-19 pandemic in 2020 also implies a negative supply shock. Although the magnitudes differ, characterizing the COVID-19 pandemic in Bhutan as a supply shock coincides with preceding episodes that were also primarily driven by supply shocks.

The Relationship Between Physical Activity, Sleep Quality, And Stress: A Study Of Teachers During The Covid-19 Pandemic, Fabio Fontana, Kelsey Bourbeau, Terence Moriarty, Michael Pereira Da Silva

Faculty Publications

The COVID-19 pandemic prompted chaotic changes in the daily lives of K-12 teachers, resulting in increased stress and other mental health problems. Limited evidence regarding the relationship between physical activity, sleep, and perceived stress among teachers during the COVID-19 pandemic exists. Therefore, the purpose of this study was to investigate the association between physical activity, sleep quality, and perceived psychological stress among teachers during the COVID-19 pandemic. An online survey measuring physical activity, sleep quality, and perceived psychological stress was distributed across 47 US states between September and October of 2020. Data provided by 635 teachers (mean age: 42 ± …

Coping Strategies And Self-Compassion As Protective Factors In The Infant And Early Childhood Mental Health Workforce, Megan Wolff

Electronic Theses and Dissertations

The mental health field experiences high levels of stress, resulting in a greater risk of poor professional quality of life, likely exacerbated by the additional stress associated with COVID-19. The present study examined the effect COVID-19 stress had on the professional quality of life of the infant and early childhood mental health (IECMH) workforce and whether coping strategies and self-compassion acted as protective factors. Results indicated that higher COVID-19 stress was associated with higher burnout and secondary traumatic stress (STS) and lower compassion satisfaction (CS). The results also showed that the pathway from COVID-19 stress to burnout was moderated by …

Association Of Initial Sars-Cov-2 Test Positivity With Patient-Reported Well-Being 3 Months After A Symptomatic Illness., Lauren E Wisk, Michael A Gottlieb, Erica S Spatz, Huihui Yu, Ralph C Wang, B. H. Slovis, Sharon Saydah, Ian D Plumb, Kelli N O'Laughlin, Juan Carlos C Montoy, Samuel A Mcdonald, Zhenqiu Lin, Jin-Mann S Lin, Katherine Koo, Ahamed H Idris, Ryan M Huebinger, Mandy J Hill, Nicole L Gentile, Anna Marie Chang, Jill Anderson, Bala Hota, Arjun K Venkatesh, Robert A Weinstein, Joann G Elmore, Graham Nichol

Department of Emergency Medicine Faculty Papers

IMPORTANCE: Long-term sequelae after symptomatic SARS-CoV-2 infection may impact well-being, yet existing data primarily focus on discrete symptoms and/or health care use.

OBJECTIVE: To compare patient-reported outcomes of physical, mental, and social well-being among adults with symptomatic illness who received a positive vs negative test result for SARS-CoV-2 infection.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study was a planned interim analysis of an ongoing multicenter prospective longitudinal registry study (the Innovative Support for Patients With SARS-CoV-2 Infections Registry [INSPIRE]). Participants were enrolled from December 11, 2020, to September 10, 2021, and comprised adults (aged ≥18 years) with acute symptoms suggestive …

Healthcare In A Time Of Crisis: An Investigation Of The Association Between Socioeconomic Status, Counties, And Covid-19, Jorge F. Contreras

Theses and Dissertations

The COVID-19 pandemic has stressed social structural institutions such as hospitals, schools, the economy, and governmental bodies (local, state, and federal), exacerbating existing health inequality. Fundamental Cause Theory (FCT) provides a framework for understanding which factors drive such inequality, but its primary focus is on within-group variation. By highlighting the role of fundamental causes as systems of exposure, the Systems-of-Exposure (SOE) approach expands on FCT to account for variation more directly between populations. I performed a Qualitative Comparative Analysis (QCA) of county-level data from Texas and California to test the utility of SOE in assessing the impact of a pandemic …

Creating A Culture Of Learning: Intrinsic Motivation And Its Practical Value In The Wake Of The Covid-19 Pandemic, Paige Hennen

Senior Honors Theses

In the wake of the COVID-19 pandemic, students of all ages were required to rapidly transition to the demands of virtual learning, resulting in general amotivation. These changes have led to poor academic performance, due to the decreased efficiency of learning processes as these students learn to cope with the instability caused by the pandemic as well as school-related changes. Intrinsic motivation, especially when cultivated within the learning process, plays an important role in student academic success and acts as an influence on holistic success in adulthood. Thus, educators must cater to the needs of this generation's students by implementing …

Navigating Through A Pandemic (The Unknown): The Effects Of Synchronous Learning For Online And In Person Students On Achievement Scores In Reading And Math In A Private Catholic School In South Texas, Israel Martinez Jr.

Theses and Dissertations

In the Spring of 2020, a wide world pandemic, specifically COVID-19, slammed the door on what we defined as normal life. COVID-19 and its associated pandemic exposed more explicitly great inequities such as access to devices, platforms, and/or places to do schoolwork outside schools in education systems (Fullan, 2020). It also interrupted international travel, it devastated economic growth, and it disrupted schooling globally (Harris & Jones, 2020). In the Summer of 2020, a Catholic school in South Texas set a plan in place to provide a 100% synchronous way of learning for students in elementary grades 1 through 8 to …

Estimating Sewage Flow Rate In Jefferson County, Kentucky, Using Machine Learning For Wastewater-Based Epidemiology Applications., Dhiraj Kanneganti, Lauren E. Reinersman, Rochelle H. Holm, Ted Smith

Faculty and Staff Scholarship

Direct measurement of the flow rate in sanitary sewer lines is not always feasible and is an important parameter for the normalization of data used in wastewater-based epidemiology applications. Machine learning to estimate past wastewater influent flow rates supporting public health applications has not been studied. The aim of this study was to assess wastewater treatment plant influent flow rates when compared with weather data and to retrospectively estimate flow rates in Louisville, Kentucky (USA), based on other data types using machine learning. A random forest model was trained using a range of variables, such as feces-related indicators, weather data …

What Does It Mean To Take Online Classes As An International Student During Covid-19?, Katie K. Koo, Mei Jiang

Faculty Publications

Using the Theory of Social Support and the Community of Inquiry as theoretical frameworks, this qualitative study explored international students’ experiences, challenges, and perceptions of online learning environments during the COVID-19 pandemic in the United States. By conducting three virtual focus group interviews with 18 international students, we identified four key themes that encapsulate participants’ challenges and experiences of online learning: social isolation in online learning spaces, difficulties with engaging in online class discussions and activities, limited opportunities for improving English proficiency in the online setting and limited academic support from faculty and advisors. Implications for research and practice to …

Impact Of Diabetes Status And Related Factors On Covid-19-Associated Hospitalization: A Nationwide Retrospective Cohort Study Of 116,370 Adults With Sars-Cov-2 Infection., Erin M. Tallon, Osagie Ebekozien, Janine Sanchez, Vincent S. Staggs, Diana Ferro, Ryan Mcdonough, Carla Demeterco-Berggren, Sarit Polsky, Patricia Gomez, Neha Patel, Priya Prahalad, Ori Odugbesan, Priyanka Mathias, Joyce M. Lee, Chelsey Smith, Chi-Ren Shyu, Mark A. Clements

Manuscripts, Articles, Book Chapters and Other Papers

Aims: We examined diabetes status (no diabetes; type 1 diabetes [T1D]; type 2 diabetes [T2D]) and other demographic and clinical factors as correlates of coronavirus disease 2019 (COVID-19)-related hospitalization. Further, we evaluated predictors of COVID-19-related hospitalization in T1D and T2D.

Methods: We analyzed electronic health record data from the de-identified COVID-19 database (December 2019 through mid-September 2020; 87 US health systems). Logistic mixed models were used to examine predictors of hospitalization at index encounters associated with confirmed SARS-CoV-2 infection.

Results: In 116,370 adults ( >=18 years old) with COVID-19 (93,098 no diabetes; 802 T1D; 22,470 T2D), factors that independently increased …

Alleviating Labor Crunch In Singapore's Hospitality Industry, Chuah Peini

UNLV Theses, Dissertations, Professional Papers, and Capstones

The acute shortage of manpower in hospitality workforce has been a persistent problem in Singapore throughout these years which adversely affects both the managerial and lower-skilled occupational groups of employees. The pandemic has further accelerated human resource issues across the country in 2020. It particularly hits the hospitality industry hard since hotel businesses are highly human-centric and the unprecedented world event has adversely resulted in severe manpower leakages and a dilution of talent pool. This paper will analyze the reasons, severity and impact of the manpower shortage within the hospitality industry in Singapore, focusing on service quality. Lastly, the author …

Association Of Initial Sars-Cov-2 Test Positivity With Patient-Reported Well-Being 3 Months After A Symptomatic Illness, Lauren E Wisk, Michael A Gottlieb, Erica S Spatz, Huihui Yu, Ralph C Wang, Benjamin H Slovis, Sharon Saydah, Ian D Plumb, Kelli N O'Laughlin, Juan Carlos C Montoy, Samuel A Mcdonald, Zhenqiu Lin, Jin-Mann S Lin, Katherine Koo, Ahamed H Idris, Ryan M Huebinger, Mandy J Hill, Nicole L Gentile, Anna Marie Chang, Jill Anderson, Bala Hota, Arjun K Venkatesh, Robert A Weinstein, Joann G Elmore, Graham Nichol, Inspire Group

Faculty, Staff and Student Publications

IMPORTANCE: Long-term sequelae after symptomatic SARS-CoV-2 infection may impact well-being, yet existing data primarily focus on discrete symptoms and/or health care use.

OBJECTIVE: To compare patient-reported outcomes of physical, mental, and social well-being among adults with symptomatic illness who received a positive vs negative test result for SARS-CoV-2 infection.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study was a planned interim analysis of an ongoing multicenter prospective longitudinal registry study (the Innovative Support for Patients With SARS-CoV-2 Infections Registry [INSPIRE]). Participants were enrolled from December 11, 2020, to September 10, 2021, and comprised adults (aged ≥18 years) with acute symptoms suggestive …

Liver Injury After Sars‐Cov‐2 Vaccination: Features Of Immune-Mediated Hepatitis, Role Of Corticosteroid Therapy And Outcome, Cumali Efe, Anand V Kulkarni, Benedetta Terziroli Beretta-Piccoli, Bianca Magro, Albert Stättermayer, Mustafa Cengiz, Daniel Clayton-Chubb, Craig Lammert, Christine Bernsmeier, Özlem Gül, Fatima Higuera-De La Tijera, Margarita Anders, Ellina Lytvyak, Mete Akın, Tugrul Purnak, Rodrigo Liberal, Mirta Peralta, Berat Ebik, Serkan Duman, Nurhan Demir, Yasemin Balaban, Álvaro Urzua, Fernando Contreras, Maria Grazia Venturelli, Yılmaz Bilgiç, Adriana Medina, Marcos Girala, Fulya Günşar, Maria-Carlota Londoño, Theodoros Androutsakos, Ayelen Kisch, Alper Yurci, Fatih Güzelbulut, Yasir Furkan Çağın, Enver Avcı, Murat Akyıldız, Emine Kübra Dindar-Demiray, Murat Harputluoğlu, Rahul Kumar, Sanjaya K Satapathy, Manuel Mendizabal, Marcelo Silva, Stefano Fagiuoli, Stuart K Roberts, Neşe Karadağ Soylu, Ramazan Idilman, Eric M Yoshida, Aldo J Montano-Loza, George N Dalekos, Ezequiel Ridruejo, Thomas D Schiano, Staffan Wahlin

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: A few case reports of autoimmune hepatitis-like liver injury have been reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. We evaluated clinical features, treatment response and outcomes of liver injury following SARS-CoV-2 vaccination in a large case series.

APPROACH AND RESULTS: We collected data from cases in 18 countries. The type of liver injury was assessed with the R-value. The study population was categorized according to features of immune-mediated hepatitis (positive autoantibodies and elevated immunoglobulin G levels) and corticosteroid therapy for the liver injury. We identified 87 patients (63%, female), median age 48 (range: 18-79) …

Airway Mucus Dysfunction In Covid-19, Burton F Dickey, Jichao Chen, R Stokes Peebles

Faculty, Staff and Student Publications

No abstract provided.

Shaping Ott Movie Consumption Through Immersive Cinema: A Qualitative Investigation Of Consumer Perspectives, Avirupa Basu, Pratap C. Mandal, Ashutosh. B. Murti, Tamas Makany, Tamas Makany

Research Collection Lee Kong Chian School Of Business

Due to the COVID-19 pandemic, the entertainment sector saw a worldwide disruption with restrictions on outdoor activities. Consequently, consumers turned towards video and music streaming services for their entertainment consumption. Several film studios have taken the digital release route on over-the-top (OTT) sites to avoid revenue losses and indefinite delays. However, these non-theatrical OTT film releases need to experiment with different strategies to bring the experiences to par with theatrical ones. This exploratory study aims to provide insights on whether Immersive Cinema can be used to imitate the physical world through digital simulation on OTT platforms to gain credibility in …

Massive Macroglossia, A Rare Side Effect Of Covid-19: Clinical, Histologic, And Genomic Findings In Covid-19-Positive Versus Covid-19-Negative Patients, Victoria A Mañón, David Chubb, Laura S Farach, Rachid Karam, Mary C Farach-Carson, Nadarajah Vigneswaran, Karan Saluja, Simon Young, Mark Wong, James C Melville

Faculty, Staff and Student Publications

PURPOSE: The primary purpose of this study is to identify if there is an underlying genetic predisposition for COVID-related macroglossia and if this susceptibility is higher among individuals of African heritage. Secondary objectives include determining if genetic testing of COVID-infected patients who are intubated and prone could identify patients with higher susceptibility to the development of macroglossia.

METHODS: A retrospective chart review was completed for each patient, and prospectively, genetic and histopathologic analyses were completed. Whole-exome sequencing was completed on two patients; immunohistochemistry was completed on the COVID-positive tissue samples.

RESULTS: Histopathology of the COVID-positive patient revealed significant peri-lymphocytic infiltrate, …

India Field Epidemiology Training Program Response To Covid-19 Pandemic, 2020-2021, Sujeet Kumar Singh, Tanzin Dikid, Meera Dhuria, Arti Bahl, Ramesh Chandra, Vaisakh Thandayamparambil Pradeep, Surendra Mohan Prajapati, Nishant Nirwan, Lipsy Paul, Manoj Murhekar, Prabhdeep Kaur, Ganeshkumar Parasuraman, Prashant Bhat, Sheila Longkumer, Kevisetuo Anthony Dzeyie, Pankaj Bhatnagar, Nhu Nguyen Tran Minh, Sukarma Tanwar, Rajesh Yadav, Meghna Desai

Faculty, Staff and Student Publications

The India Field Epidemiology Training Program (FETP) has played a critical role in India's response to the ongoing COVID-19 pandemic. During March 2020-June 2021, a total of 123 FETP officers from across 3 training hubs were deployed in support of India's efforts to combat COVID-19. FETP officers have successfully mitigated the effect of COVID-19 on persons in India by conducting cluster outbreak investigations, performing surveillance system evaluations, and developing infection prevention and control tools and guidelines. This report discusses the successes of select COVID-19 pandemic response activities undertaken by current India FETP officers and proposes a pathway to augmenting India's …

Ubiquitin Variants Potently Inhibit Sars-Cov-2 Plpro And Viral Replication Via A Novel Site Distal To The Protease Active Site, Vera J. E. Van Vliet, Nitin Sharma, Safder S. Ganaie, Gaya K. Amarasinghe, Et Al

2020-Current year OA Pubs

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of vaccines and therapeutics. A promising drug target common to all coronaviruses-including SARS-CoV, MERS-CoV, and SARS-CoV-2-is the papain-like protease (PLpro). PLpro cleaves part of the viral replicase polyproteins into non-structural protein subunits, which are essential to the viral replication cycle. Additionally, PLpro can cleave both ubiquitin and the ubiquitin-like protein ISG15 from host cell substrates as a mechanism to evade innate immune responses during infection. These roles make PLpro an attractive antiviral drug target. Here we demonstrate that ubiquitin …

Approaches To Healthcare Personnel Exemption Requests From Coronavirus Disease 2019 (Covid-19) Vaccination: Results Of A National Survey, Thomas R Talbot, Susan E Beekmann, Hilary M Babcock, Philip M Polgreen

2020-Current year OA Pubs

OBJECTIVE: Although a growing number of healthcare facilities are implementing healthcare personnel (HCP) coronavirus disease 2019 (COVID-19) vaccination requirements, vaccine exemption request management as a part of such programs is not well described.

DESIGN: Cross-sectional survey.

PARTICIPANTS: Infectious disease (ID) physician members of the Emerging Infections Network with infection prevention or hospital epidemiology responsibilities.

METHODS: Eligible persons were sent a web-based survey focused on hospital plans and practices around exemption allowances from HCP COVID-19 vaccine requirements.

RESULTS: Of the 695 ID physicians surveyed, 263 (38%) responded. Overall, 160 respondent institutions (92%) allowed medical exemptions, whereas 132 (76%) allowed religious exemptions. …

Wellness And Coping Of Physicians Who Worked In Icus During The Pandemic: A Multicenter Cross-Sectional North American Survey, Karen E. A. Burns, Rachel K. Mcdonald, Et Al.

2020-Current year OA Pubs

OBJECTIVES: Few surveys have focused on physician moral distress, burnout, and professional fulfilment. We assessed physician wellness and coping during the COVID-19 pandemic.

DESIGN: Cross-sectional survey using four validated instruments.

SETTING: Sixty-two sites in Canada and the United States.

SUBJECTS: Attending physicians (adult, pediatric; intensivist, nonintensivist) who worked in North American ICUs.

INTERVENTION: None.

MEASUREMENTS AND MAIN RESULTS: We analysed 431 questionnaires (43.3% response rate) from 25 states and eight provinces. Respondents were predominantly male (229 [55.6%]) and in practice for 11.8 ± 9.8 years. Compared with prepandemic, respondents reported significant intrapandemic increases in days worked/mo, ICU bed occupancy, and …

Responses To Covid-19 Threats: An Evolutionary Psychological Analysis., Stephen M. Colarelli, Tyler J. Mirando, Kyunghee Han, Norman P. Li, Carter Vespi, Katherine A. Klein, Charles P. Fales

Research Collection School of Social Sciences

Responses to COVID-19 public health interventions have been lukewarm. For example, only 64% of the US population has received at least two vaccinations. Because most public health interventions require people to behave in ways that are evolutionarily novel, evolutionary psychological theory and research on mismatch theory, the behavioral immune system, and individual differences can help us gain a better understanding of how people respond to public health information. Primary sources of threat information during the pandemic (particularly in early phases) were geographic differences in morbidity and mortality statistics. We argue that people are unlikely to respond to this type of …

Assessing The Impact Of Non-Pharmaceutical Interventions (Npis) And Bcg Vaccine Cross-Protection In The Transmission Dynamics Of Sars-Cov-2 In Eastern Africa, Chelsea Mbeke Kilonzo, Mark Wamalwa, Solange Youdom Whegang, Henri E.Z. Tonnang

All Peer-Reviewed Publications

Objective: The outbreak of the novel coronavirus disease 2019 (COVID-19) is still affecting African countries. The pandemic presents challenges on how to measure governmental, and community responses to the crisis. Beyond health risks, the socio-economic implications of the pandemic motivated us to examine the transmission dynamics of COVID-19 and the impact of non-pharmaceutical interventions (NPIs). The main objective of this study was to assess the impact of BCG vaccination and NPIs enforced on COVID-19 case-death-recovery counts weighted by age-structured population in Ethiopia, Kenya, and Rwanda. We applied a semi-mechanistic Bayesian hierarchical model (BHM) combined with Markov Chain Monte Carlo (MCMC) …

Using Outbreak Data To Estimate The Dynamic Covid-19 Landscape In Eastern Africa, Mark Wamalwa, Henri E.Z. Tonnang

All Peer-Reviewed Publications

Background: The emergence of COVID-19 as a global pandemic presents a serious health threat to African countries and the livelihoods of its people. To mitigate the impact of this disease, intervention measures including self-isolation, schools and border closures were implemented to varying degrees of success. Moreover, there are a limited number of empirical studies on the effectiveness of non-pharmaceutical interventions (NPIs) to control COVID-19. In this study, we considered two models to inform policy decisions about pandemic planning and the implementation of NPIs based on case-death-recovery counts. Methods: We applied an extended susceptible-infected-removed (eSIR) model, incorporating quarantine, antibody and vaccination …

Dc-Sign Receptor Level In Rheumatoid Arthritis Patients In Baghdad; Serological Study, Hayam A. Mohammed, Zahra’A A. Ahmed, Aymen A. Othman Alrawi

Baghdad Science Journal

Rheumatoid arthritis (RA), is an autoimmune, and inflammatory disease that is closely related to the destruction of cartilage and bone. DC-SIGN are important types of C-type lectin receptors (CLRs), expressed on dendritic cells and macrophages, and have a central role in regulating innate and adaptive immunity, function as pattern recognition receptors, and as cell adhesion molecules. Recent evidence has demonstrated that DC-SIGN is involved in the pathophysiological of chronic inflammation, so DC-SIGN has been linked to several autoimmune and may play an essential indicator in the pathogenesis and progression of RA. Therefore, the purpose of this study is to determine …

Genetic Liability Between Covid-19 And Heart Failure: Evidence From A Bidirectional Mendelian Randomization Study, Huachen Wang, Zheng Guo, Yulu Zheng, Bing Chen

Research outputs 2022 to 2026

Background: Previous studies have observed inconsistent associations between coronavirus disease 2019 (COVID-19) and heart failure (HF), but these studies were prone to bias based on reverse causality and residual confounding factors. We aimed to investigate genetic liability between COVID-19 and heart failure using a bidirectional Mendelian randomization study. Methods: The causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and HF are determined by using a bidirectional Mendelian randomization analysis. We drew on summary statistics from the largest HF genome-wide association study (GWAS) meta-analysis on individuals of European ancestry, which included 47,309 HF …