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Modelling Medical-Surgical Nurse Workload And Care Quality During Covid-19: Implications For Building Healthy Work Environments, Sue Bookey-Bassett, Michael Greig, Helen Kelly, W. Patrick Neumann, Nancy Purdy, Sadeem M. Qureshi Jul 2023

Modelling Medical-Surgical Nurse Workload And Care Quality During Covid-19: Implications For Building Healthy Work Environments, Sue Bookey-Bassett, Michael Greig, Helen Kelly, W. Patrick Neumann, Nancy Purdy, Sadeem M. Qureshi

Creating Healthy Work Environments (CHWE)

Discrete event simulation (DES) was used to measure the effects of varying COVID-19 nurse-patient ratios on nurse workload and quality of care in a Canadian medical-surgical context. As nurses were assigned to more COVID-19 positive patients, nurse workload increased and quality of care indicators deteriorated. Implications for leaders are considered.


Kangaroo Mother Care In Improving Thermoregulation Of Premature Babies During The Covid-19 Pandemic: A Case Report, Ari Damayanti Wahyuningrum, Yuni Sufyanti Arief, Rizki Fitriyasari Pk, Chui Ping Lei, Rinik Eko Kapti Jul 2023

Kangaroo Mother Care In Improving Thermoregulation Of Premature Babies During The Covid-19 Pandemic: A Case Report, Ari Damayanti Wahyuningrum, Yuni Sufyanti Arief, Rizki Fitriyasari Pk, Chui Ping Lei, Rinik Eko Kapti

Kesmas

Premature babies lose four times more heat than those with sufficient birth weight. Moreover, their body temperature regulation center does not function properly. This study aimed to investigate Kangaroo Mother Care's effect in increasing premature babies' thermoregulation during the COVID-19 pandemic at Hospital A in Malang City, Indonesia. This study was a case report with data from follow-up checks on premature babies discharged from the hospital. The Kangaroo Mother Care method, carried out by the mother, increased the thermoregulation of premature babies' temperature by 0.2ᴼC compared to the father. It was because women have a slightly higher body temperature than …


Access To Social Media, Knowledge, And Acceptance Of Covid-19 Post-Vaccination Health Protocols: A Cross-Sectional Study, Ni Luh Gde Armini, Dinar Saurmauli Lubis, Ni Putu Widarini Jul 2023

Access To Social Media, Knowledge, And Acceptance Of Covid-19 Post-Vaccination Health Protocols: A Cross-Sectional Study, Ni Luh Gde Armini, Dinar Saurmauli Lubis, Ni Putu Widarini

Kesmas

The health protocols recommended by the health authorities still need to be practiced after having the COVID-19 vaccine. Education on the prevention of COVID-19 infection needs to continue to protect people from the disease. This study aimed to determine the factors associated with adhering to COVID-19post-vaccination health protocols in people aged 18 years and over in the South Denpasar Subdistrict. This cross-sectional study comprised a sample of 147 people who were selected by incidental sampling. The data were obtained using questionnaires from July to August 2022 and examined with bivariate and multivariate analysis. Most participants were female, private employees, went …


Pastoral Leadership As A Perceived Factor Of Changing Church Membership In South Carolina: A Phenomenological Study, Bobby L. Dukes Jul 2023

Pastoral Leadership As A Perceived Factor Of Changing Church Membership In South Carolina: A Phenomenological Study, Bobby L. Dukes

Doctoral Dissertations and Projects

The role of a pastor comprises many duties and responsibilities within the church; some have led to chaos. Clinton et al. (2005), states many churches are mired in a significant leadership crisis (p. 10). Pastors are called to lead people in spiritual growth, with the end goal of parishioners living a mature spiritual life for the sake of Christ, not the contrary. The enormity of pastoral leadership has a lasting effect. Kristin Tabb (2017) claims that relatively minor church hurts leave people with a burned-out feeling during service, while the more serious wounds leave parishioners soul-scarred and physically sick at …


Self-Care For Counselors During The Covid-19 Pandemic, Penney Siddiqui Jul 2023

Self-Care For Counselors During The Covid-19 Pandemic, Penney Siddiqui

Doctoral Dissertations and Projects

COVID-19 took the world by surprise early in 2020, and rapidly became a global threat. While not the first global pandemic declared by the World Health Organization, COVID-19 was different from past pandemics both in the speed of transmission and in the psychosocial impact. Not only did COVID-19 impact the physical health of those who contracted the virus, it also impacted the mental health of the general population. Mental health counselors held a dual role in this pandemic, facing the psychosocial impact themselves while simultaneously providing care for others. Recent studies explored the psychosocial impact on health care professionals and …


Whether Covid-19 Infection Affects Human Cognitive Function, June Li Alsgaard Jul 2023

Whether Covid-19 Infection Affects Human Cognitive Function, June Li Alsgaard

Doctoral Dissertations and Projects

The COVID-19 pandemic, resulting from the SARS-CoV-2 virus, continues to impact the daily lives of individuals worldwide. Although research has been conducted on long-COVID symptoms, the underlying causes remain unclear. Notably, instances of neurological decline have been observed following SARS-CoV-2 infections. 125,573 articles regarding neurological damage and cognitive disfunction were published and can be found from major research databases. For this scholarly project, 25 peer-reviewed journal articles pertaining to long-COVID and neurologic function changes, as well as potential underlying reasons for these changes, were curated. The proposed hypotheses include the virus' ability to pass through and harm the blood-brain barrier …


Knowledge Acquisition Efficacy Of A Remote Flipped Classroom On Learning About Removable Partial Dentures, Yuka Inamochi, Eiko Yoshida Kohno, Junichiro Wada, Natsuko Murakami, Atsushi Takaichi, Yuki Arai, Takeshi Ueno, Kenji Fueki, Noriyuki Wakabayashi Jul 2023

Knowledge Acquisition Efficacy Of A Remote Flipped Classroom On Learning About Removable Partial Dentures, Yuka Inamochi, Eiko Yoshida Kohno, Junichiro Wada, Natsuko Murakami, Atsushi Takaichi, Yuki Arai, Takeshi Ueno, Kenji Fueki, Noriyuki Wakabayashi

Faculty, Staff and Student Publications

Purpose: Coronavirus disease 2019 has forced the use of remote education worldwide. In 2020, the authors conducted a fully digitized, remote flipped (RF) classroom focusing on removable partial dentures. This study aimed to evaluate the learning outcomes of the RF classroom and compare these with those of the on-site classroom.

Methods: The fourth-year dental students in 2017-2019 attended on-site flipped classroom (OF; n=70) or on-site lecture classroom (OL; n=67), and those in 2020 (n=58) attended the RF classroom. Lecture videos and text were provided online in the OF and RF groups, while only the text was given to the OL …


Sars-Cov-2 Uses Cd4 To Infect T Helper Lymphocytes, Natalia S Brunetti, Louis-Marie Bloyet, Spencer Stumpf, Marjorie C Pontelli, Sean Whelan, Alessandro S Farias, Et Al. Jul 2023

Sars-Cov-2 Uses Cd4 To Infect T Helper Lymphocytes, Natalia S Brunetti, Louis-Marie Bloyet, Spencer Stumpf, Marjorie C Pontelli, Sean Whelan, Alessandro S Farias, Et Al.

2020-Current year OA Pubs

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4


Use Of Social Media Platforms In Disseminating Information Amid Covid-19 Pandemic In Technical University Libraries In Ghana, Jennifer Kyerewaa Antwi Ms., Akwasi Duffour Frimpong Mr. Jul 2023

Use Of Social Media Platforms In Disseminating Information Amid Covid-19 Pandemic In Technical University Libraries In Ghana, Jennifer Kyerewaa Antwi Ms., Akwasi Duffour Frimpong Mr.

Library Philosophy and Practice (e-journal)

Abstract

Educational institutions have undergone tremendous changes through the usage of technology-based applications. Academic libraries however have not been left out of this transition since the libraries are instituted in the university and the heart of the institution. The study aimed to examine social media use to disseminate information amid the Covid-19 pandemic in Technical University libraries. A qualitative research approach was used with semi-structured interviews used to collect data from ten participants. The findings revealed that most of the participants made use of social media like Facebook, YouTube, Instagram, and WhatsApp to disseminate information during the pandemic in both …


The Extent Of Knowledge, Preparedness And Perception Of Telemedicine Among Family Medicine Residents In Cebu City During Covid-19, Kristine Joy Y. Sumanga, Clarissa Mae D. Derecho Jul 2023

The Extent Of Knowledge, Preparedness And Perception Of Telemedicine Among Family Medicine Residents In Cebu City During Covid-19, Kristine Joy Y. Sumanga, Clarissa Mae D. Derecho

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Telemedicine is providing healthcare services using electronic means at a distance including the diagnosis, treatment, and prevention of diseases as well as the research and evaluation, and education of healthcare providers. Its role in the time of the pandemic is vital, especially to the practice of medicine. This study is a descriptive, cross-sectional, survey research study conducted in four hospital training institutions in Cebu City. A total of 41 respondents gave their consent and were given the online survey questionnaire about the extent of knowledge, preparedness and perceptions of telemedicine. Out of the 41 respondents, 56.10% were young adults (26-30 …


Engaging Mothers And Community Health Workers: An Online Maternal And Children’S Health Education In Kampung Lio, Indonesia, Shafira Aurelia, Dheanita Nissrina Andini, Garry Soloan, Vahira Waladhiyaputri, Dewi Friska Jul 2023

Engaging Mothers And Community Health Workers: An Online Maternal And Children’S Health Education In Kampung Lio, Indonesia, Shafira Aurelia, Dheanita Nissrina Andini, Garry Soloan, Vahira Waladhiyaputri, Dewi Friska

ASEAN Journal of Community Engagement

To raise awareness and understanding of maternal and children’s health, a team from Faculty of Medicine, Universitas Indonesia, Indonesia, conducted a program called Tinggi Cerdas. It is a community development program in Kampung Lio, Depok, West Java. This article evaluates the impacts of activity related to the participant’s awareness and knowledge about maternal and children’s health. The program was developed and conducted as an online program due to the COVID-19 pandemic situation, from September to December 2021. The program was developed with four different topics through online communication, equipped with an educational booklet for the mothers and a PrimaKu® application …


Association Of Delirium And Depression With Respiratory And Outcome Measures In Covid-19 Inpatients, Alessio Simonetti, Cristina Pais, Vezio Savoia, Maria Camilla Cipriani, Matteo Tosato, Delfina Janiri, Evelina Bernardi, Ottavia Marianna Ferrara, Stella Margoni, Georgios D Kotzalidis, Daniela Chieffo, Massimo Fantoni, Rosa Liperoti, Francesco Landi, Roberto Bernabei, Gabriele Sani Jul 2023

Association Of Delirium And Depression With Respiratory And Outcome Measures In Covid-19 Inpatients, Alessio Simonetti, Cristina Pais, Vezio Savoia, Maria Camilla Cipriani, Matteo Tosato, Delfina Janiri, Evelina Bernardi, Ottavia Marianna Ferrara, Stella Margoni, Georgios D Kotzalidis, Daniela Chieffo, Massimo Fantoni, Rosa Liperoti, Francesco Landi, Roberto Bernabei, Gabriele Sani

Faculty, Staff and Students Publications

Delirium (DEL) and depression (DEP) may impair the course and severity of acute respiratory illness. The impact of such syndromes on respiratory and outcome parameters in inpatients with COVID-19 needs clarification. To clarify the relationship between DEL and DEP and respiratory outcome measures, we enrolled 100 inpatients from COVID-19 units of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS of Rome. Participants were divided into those with DEL, DEP, or absence of either delirium or depression (CONT). Delirium severity was assessed with the Neelson and Champagne Confusion Scale (NEECHAM). Psychopathology was assessed with the Hamilton Rating Scale for Depression (HAM-D), the …


Crisis And Revitalization Of Rural Tourism In The Appalachian Region Amidst The Pandemic: The Perspective Of Key Stakeholders, Nikol Lopez Llantuy, Sandy Chen Jul 2023

Crisis And Revitalization Of Rural Tourism In The Appalachian Region Amidst The Pandemic: The Perspective Of Key Stakeholders, Nikol Lopez Llantuy, Sandy Chen

ICHRIE Research Reports

The COVID-19 pandemic has forced everyone to rethink their business activities. Due to being distant from crowded cities, rural tourism destinations have become getaway places, with some counties in rural Ohio experiencing an influx of tourists. This study addresses responses from key stakeholders of tourism and tourism development activities in two counties in southeastern Ohio, part of the Appalachian region. Their perceptions of the impacts of the pandemic on local tourism and tourism activities were examined using a qualitative approach. Findings suggested both positive and negative impacts of COVID-19, showing the challenges faced, and the strategies used during the pandemic. …


New Corona Virus Provokes Peripheral Gangrene In Lower Limb Of Type-1 Diabetic Patient: A Case Report, Hussein A. Ghanimi, Diaa K. Abd Ali Jul 2023

New Corona Virus Provokes Peripheral Gangrene In Lower Limb Of Type-1 Diabetic Patient: A Case Report, Hussein A. Ghanimi, Diaa K. Abd Ali

Al-Ameed Journal for Medical Research and Health Sciences

Introduction: Corona virus disease 2019 (COVID-19) presents with un-expected complications. Diabetic patients are more susceptible for lower limb complications. Importance: Peripheral gangrene may be associated with COVID-19 in diabetic patients. Case presentation: We described one diabetic patient with COVID-19 associated peripheral gangrene (PG) in lower limb. A 56 years old female patient with type-1 diabetes tested positive for COVID-19. She suffered from PG in her left foot. Hematological, biochemical, Doppler sonography, echocardiography (Echo) and electrocardiogram (ECG) tests were done for diagnosis and evaluation of the case. General checkup indicated presence of an abscess in her foot. Later, abscess drainage surgery …


Perceptions Of Covid-19 And The Use Of Health Information Technology Among People Who Are Uninsured: Multimethod Survey Study, Khushi S. Patel, Cynthia F. Corbett Phd, Rn, Faan, Elizabeth M. Combs, Sara B. Donevant, Margaret J. Selph, Lynette M. Gibson, Robin Dawson Phd, Rn, Cpnp-Pc, Amit P. Sheth, Ronda G. Hughes Jul 2023

Perceptions Of Covid-19 And The Use Of Health Information Technology Among People Who Are Uninsured: Multimethod Survey Study, Khushi S. Patel, Cynthia F. Corbett Phd, Rn, Faan, Elizabeth M. Combs, Sara B. Donevant, Margaret J. Selph, Lynette M. Gibson, Robin Dawson Phd, Rn, Cpnp-Pc, Amit P. Sheth, Ronda G. Hughes

Publications

BACKGROUND: As of May 2023, the novel SARS-CoV-2 has claimed nearly 7 million lives globally and >1.1 million lives in the United States. Low-income populations are often disproportionately affected by risk factors such as lifestyle, employment, and limited health literacy. These populations may lack the knowledge of appropriate infection precautions or have reduced access to care during illness, particularly in countries without universal health care.

OBJECTIVE: We aimed to explore the perceptions and experiences of COVID-19, including symptoms and risk factors among uninsured individuals seeking care at a free medical clinic, and to obtain respondents' perceptions of and suggestions for …


25th Annual Open Government Summit: Your Guide To The Access To Public Records Act & Open Meetings Act, Peter F. Neronha, Roger Williams University School Of Law Jul 2023

25th Annual Open Government Summit: Your Guide To The Access To Public Records Act & Open Meetings Act, Peter F. Neronha, Roger Williams University School Of Law

School of Law Conferences, Lectures & Events

No abstract provided.


Establishing Validity And Preliminary Clinical Utility Of A Behavioral Economic Measure Of Social Risk Discounting For Health Behaviors, Connor A. Burrows Jul 2023

Establishing Validity And Preliminary Clinical Utility Of A Behavioral Economic Measure Of Social Risk Discounting For Health Behaviors, Connor A. Burrows

Theses and Dissertations

The COVID-19 pandemic has been the most profound public health emergency of the past several decades and the United States has faced numerous challenges with the timely adoption of mitigating health behaviors. Sustained ambivalence surrounding perceptions of public health recommendations of social distancing, mask wearing, and timely vaccination remain a barrier to slowing the spread of the virus years after its initial onset. Behavior analysis and behavioral economics offer compelling theoretical and quantitative models for framing the relationship between behaviors that are aversive in the short term but beneficial for individual and public good in the long term. The present …


Does Using Sofa Score For Ventilator Triage Among Covid 19 Patients Result In Suboptimal Allocation Of Medical Ventilators For The Bipoc Population?, Alexandrea Mp Masocco, Elisabeth Michel, Ebbin Dotson Jul 2023

Does Using Sofa Score For Ventilator Triage Among Covid 19 Patients Result In Suboptimal Allocation Of Medical Ventilators For The Bipoc Population?, Alexandrea Mp Masocco, Elisabeth Michel, Ebbin Dotson

Journal of Health Disparities Research and Practice

Introduction: Since the COVID-19 pandemic in the United States, Black, and Latinx populations have been disproportionately affected by the COVID-19 pandemic. It can be inferred with high confidence that those most vulnerable are the least likely to receive essential care. Kidney transplant allocation and COVID-19 triage protocols share commonalities in that both protocols involve using multivariate scored criteria with objective and subjective inputs. As such, the similar conclusion in outcomes is concerning. It is worth questioning whether the racial inequalities demonstrated in the COVID-19 pandemic related to access to life-saving ventilators were associated with triage protocols.

Methodology: Using an exploratory …


The Covid Whirlwind On The Veterinary World: End-Of-Life Care And Euthanasia During The Covid-19 Pandemic, Elizabeth Chalmers, Paula Gerstenblatt, River Hodgdon Jul 2023

The Covid Whirlwind On The Veterinary World: End-Of-Life Care And Euthanasia During The Covid-19 Pandemic, Elizabeth Chalmers, Paula Gerstenblatt, River Hodgdon

People and Animals: The International Journal of Research and Practice

Veterinary providers experience job-specific psychological stress from their dual role in both providing medical care to pets and supporting pet-owner clients through end-of-life care and the euthanasia process, contributing to compassion fatigue and burnout in the field. COVID-19 has impacted the provision of veterinary care and affected communication between providers and pet owners. This qualitative study explores the experiences of veterinary providers who provided end-of- life care and performed euthanasia during the COVID-19 pandemic. Participants for this qualitative study were recruited and interviewed using criterion sampling from four veterinary practices in the northeastern United States. Inductive thematic analysis was used …


Covid-19 Vaccination Hesitancy In Autoimmune Disease Patients: Policy Action And Ethical Considerations, Nardeen Shafik, Jennifer E. Akpo, Kristie C. Waterfield, William Mase Jul 2023

Covid-19 Vaccination Hesitancy In Autoimmune Disease Patients: Policy Action And Ethical Considerations, Nardeen Shafik, Jennifer E. Akpo, Kristie C. Waterfield, William Mase

Health Policy & Community Health: Faculty Publications

As COVID-19 vaccination guidelines were issued by Advisory Committee on Immunization Practices (ACIP) and the Centers for Diseases Control and Prevention (CDC) across the US, each state and clinical provider instituted vaccine implementation and education policies and protocols for high-risk populations. However, current research has shown that while people with autoimmune diseases were listed by ACIP and CDC as a COVID-19 high-risk population, the rate of adherence to implementation and education protocols, as well as the prioritization of this sub-population as a high-risk group, varied among the clinicians and vaccinators thus impacting the hesitancy towards the COVID-19 vaccine and a …


Enabling Endpoint Development For Interventional Clinical Trials In Individuals With Angelman Syndrome: A Prospective, Longitudinal, Observational Clinical Study (Freesias), Jorrit Tjeertes, Carlos A Bacino, Terry Jo Bichell, Lynne M Bird, Mariana Bustamante, Rebecca Crean, Shafali Jeste, Robert W Komorowski, Michelle L Krishnan, Meghan T Miller, David Nobbs, Cesar Ochoa-Lubinoff, Kimberly A Parkerson, Alexander Rotenberg, Anjali Sadhwani, Mark D Shen, Lisa Squassante, Wen-Hann Tan, Brenda Vincenzi, Anne C Wheeler, Joerg F Hipp, Elizabeth Berry-Kravis Jul 2023

Enabling Endpoint Development For Interventional Clinical Trials In Individuals With Angelman Syndrome: A Prospective, Longitudinal, Observational Clinical Study (Freesias), Jorrit Tjeertes, Carlos A Bacino, Terry Jo Bichell, Lynne M Bird, Mariana Bustamante, Rebecca Crean, Shafali Jeste, Robert W Komorowski, Michelle L Krishnan, Meghan T Miller, David Nobbs, Cesar Ochoa-Lubinoff, Kimberly A Parkerson, Alexander Rotenberg, Anjali Sadhwani, Mark D Shen, Lisa Squassante, Wen-Hann Tan, Brenda Vincenzi, Anne C Wheeler, Joerg F Hipp, Elizabeth Berry-Kravis

Faculty, Staff and Students Publications

BACKGROUND: Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by the absence of a functional UBE3A gene, which causes developmental, behavioral, and medical challenges. While currently untreatable, comprehensive data could help identify appropriate endpoints assessing meaningful improvements in clinical trials. Herein are reported the results from the FREESIAS study assessing the feasibility and utility of in-clinic and at-home measures of key AS symptoms.

METHODS: Fifty-five individuals with AS (aged < 5 years: n = 16, 5-12 years: n = 27, ≥ 18 years: n = 12; deletion genotype: n = 40, nondeletion genotype: n = 15) and 20 typically developing children (aged 1-12 years) were enrolled across six USA sites. Several clinical outcome assessments and digital health technologies were tested, together with overnight 19-lead electroencephalography (EEG) and additional polysomnography (PSG) sensors. Participants were assessed at baseline (Clinic Visit 1), 12 months later (Clinic Visit 2), and during intermittent home visits.

RESULTS: The participants achieved high completion rates for the clinical outcome assessments (adherence: 89-100% [Clinic Visit 1]; 76-91% [Clinic Visit 2]) and varied feasibility of and adherence to digital health …


Covid Learning Loss: A Call To Action, Nathan D. Grawe Jul 2023

Covid Learning Loss: A Call To Action, Nathan D. Grawe

Numeracy

The COVID-19 pandemic and policy responses designed to mitigate transmission have caused deep and persistent mathematics learning loss among K–12 students. While initial data might have been read optimistically as a blip that would reverse once schools returned to normal, 2023 data from the National Assessment of Educational Progress (NAEP) show that losses persist. While the NAEP does not directly measure quantitative reasoning (QR), the data present a disturbing picture for QR instruction and call for new lines of research that inform QR pedagogical response.


Genetically Diverse Mouse Models Of Sars-Cov-2 Infection Reproduce Clinical Variation In Type I Interferon And Cytokine Responses In Covid-19., Shelly J Robertson, Olivia Bedard, Kristin L Mcnally, Carl Shaia, Chad S Clancy, Matthew Lewis, Rebecca M Broeckel, Abhilash I Chiramel, Jeffrey G Shannon, Gail L Sturdevant, Rebecca Rosenke, Sarah L Anzick, Elvira Forte, Christoph Preuss, Candice N Baker, Jeffrey M. Harder, Catherine Brunton, Steven C. Munger, Daniel P Bruno, Justin B Lack, Jacqueline M Leung, Amirhossein Shamsaddini, Paul Gardina, Daniel E Sturdevant, Jian Sun, Craig Martens, Steven M Holland, Nadia Rosenthal, Sonja M Best Jul 2023

Genetically Diverse Mouse Models Of Sars-Cov-2 Infection Reproduce Clinical Variation In Type I Interferon And Cytokine Responses In Covid-19., Shelly J Robertson, Olivia Bedard, Kristin L Mcnally, Carl Shaia, Chad S Clancy, Matthew Lewis, Rebecca M Broeckel, Abhilash I Chiramel, Jeffrey G Shannon, Gail L Sturdevant, Rebecca Rosenke, Sarah L Anzick, Elvira Forte, Christoph Preuss, Candice N Baker, Jeffrey M. Harder, Catherine Brunton, Steven C. Munger, Daniel P Bruno, Justin B Lack, Jacqueline M Leung, Amirhossein Shamsaddini, Paul Gardina, Daniel E Sturdevant, Jian Sun, Craig Martens, Steven M Holland, Nadia Rosenthal, Sonja M Best

Faculty Research 2023

Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19) and is influenced by host genetics. To understand mechanisms of inflammation, animal models that reflect genetic diversity and clinical outcomes observed in humans are needed. We report a mouse panel comprising the genetically diverse Collaborative Cross (CC) founder strains crossed to human ACE2 transgenic mice (K18-hACE2) that confers susceptibility to SARS-CoV-2. Infection of CC x K18-hACE2 resulted in a spectrum of survival, viral replication kinetics, and immune profiles. Importantly, in contrast to the K18-hACE2 model, early type I interferon (IFN-I) and regulated …


Abatacept, Cenicriviroc, Or Infliximab For Treatment Of Adults Hospitalized With Covid-19 Pneumonia: A Randomized Clinical Trial, Jane A O'Halloran, Emily R Ko, Kevin J Anstrom, Eyal Kedar, Matthew W Mccarthy, Reynold A Panettieri, Martin Maillo, Patricia Segura Nunez, Anne M Lachiewicz, Cynthia Gonzalez, P Brian Smith, Sabina Mendivil-Tuchia De Tai, Akram Khan, Alfredo J Mena Lora, Matthias Salathe, Gerardo Capo, Daniel Rodríguez Gonzalez, Thomas F Patterson, Christopher Palma, Horacio Ariza, Maria Patelli Lima, John Blamoun, Esteban C Nannini, Eduardo Sprinz, Analia Mykietiuk, Radica Alicic, Adriana M Rauseo, Cameron R Wolfe, Britta Witting, Jennifer P Wang, Luis Parra-Rodriguez, Tatyana Der, Kate Willsey, Jun Wen, Adam Silverstein, Sean M O'Brien, Hussein R Al-Khalidi, Michael A Maldonado, Richard Melsheimer, William G Ferguson, Steven E Mcnulty, Pearl Zakroysky, Susan Halabi, Daniel K Benjamin, Sandra Butler, Jane C Atkinson, Stacey J Adam, Soju Chang, Lisa Lavange, Michael Proschan, Samuel A Bozzette, William G Powderly Jul 2023

Abatacept, Cenicriviroc, Or Infliximab For Treatment Of Adults Hospitalized With Covid-19 Pneumonia: A Randomized Clinical Trial, Jane A O'Halloran, Emily R Ko, Kevin J Anstrom, Eyal Kedar, Matthew W Mccarthy, Reynold A Panettieri, Martin Maillo, Patricia Segura Nunez, Anne M Lachiewicz, Cynthia Gonzalez, P Brian Smith, Sabina Mendivil-Tuchia De Tai, Akram Khan, Alfredo J Mena Lora, Matthias Salathe, Gerardo Capo, Daniel Rodríguez Gonzalez, Thomas F Patterson, Christopher Palma, Horacio Ariza, Maria Patelli Lima, John Blamoun, Esteban C Nannini, Eduardo Sprinz, Analia Mykietiuk, Radica Alicic, Adriana M Rauseo, Cameron R Wolfe, Britta Witting, Jennifer P Wang, Luis Parra-Rodriguez, Tatyana Der, Kate Willsey, Jun Wen, Adam Silverstein, Sean M O'Brien, Hussein R Al-Khalidi, Michael A Maldonado, Richard Melsheimer, William G Ferguson, Steven E Mcnulty, Pearl Zakroysky, Susan Halabi, Daniel K Benjamin, Sandra Butler, Jane C Atkinson, Stacey J Adam, Soju Chang, Lisa Lavange, Michael Proschan, Samuel A Bozzette, William G Powderly

Faculty, Staff and Student Publications

IMPORTANCE: Immune dysregulation contributes to poorer outcomes in COVID-19.

OBJECTIVE: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia.

DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-masked, placebo-controlled clinical trial using a master protocol to investigate immunomodulators added to standard care for treatment of participants hospitalized with COVID-19 pneumonia. The results of 3 substudies are reported from 95 hospitals at 85 clinical research sites in the US and Latin America. Hospitalized patients 18 years or older with confirmed SARS-CoV-2 infection within 14 days and evidence of pulmonary involvement underwent randomization between October 2020 and …


Abatacept, Cenicriviroc, Or Infliximab For Treatment Of Adults Hospitalized With Covid-19 Pneumonia: A Randomized Clinical Trial, Jane A O'Halloran, Emily R Ko, Kevin J Anstrom, Eyal Kedar, Matthew W Mccarthy, Reynold A Panettieri, Martin Maillo, Patricia Segura Nunez, Anne M Lachiewicz, Cynthia Gonzalez, P Brian Smith, Sabina Mendivil-Tuchia De Tai, Akram Khan, Alfredo J Mena Lora, Matthias Salathe, Gerardo Capo, Daniel Rodríguez Gonzalez, Thomas F Patterson, Christopher Palma, Horacio Ariza, Maria Patelli Lima, John Blamoun, Esteban C Nannini, Eduardo Sprinz, Analia Mykietiuk, Radica Alicic, Adriana M Rauseo, Cameron R Wolfe, Britta Witting, Jennifer P Wang, Luis Parra-Rodriguez, Tatyana Der, Kate Willsey, Jun Wen, Adam Silverstein, Sean M O'Brien, Hussein R Al-Khalidi, Michael A Maldonado, Richard Melsheimer, William G Ferguson, Steven E Mcnulty, Pearl Zakroysky, Susan Halabi, Daniel K Benjamin, Sandra Butler, Jane C Atkinson, Stacey J Adam, Soju Chang, Lisa Lavange, Michael Proschan, Samuel A Bozzette, William G Powderly, Activ-1 Im Study Group Members Jul 2023

Abatacept, Cenicriviroc, Or Infliximab For Treatment Of Adults Hospitalized With Covid-19 Pneumonia: A Randomized Clinical Trial, Jane A O'Halloran, Emily R Ko, Kevin J Anstrom, Eyal Kedar, Matthew W Mccarthy, Reynold A Panettieri, Martin Maillo, Patricia Segura Nunez, Anne M Lachiewicz, Cynthia Gonzalez, P Brian Smith, Sabina Mendivil-Tuchia De Tai, Akram Khan, Alfredo J Mena Lora, Matthias Salathe, Gerardo Capo, Daniel Rodríguez Gonzalez, Thomas F Patterson, Christopher Palma, Horacio Ariza, Maria Patelli Lima, John Blamoun, Esteban C Nannini, Eduardo Sprinz, Analia Mykietiuk, Radica Alicic, Adriana M Rauseo, Cameron R Wolfe, Britta Witting, Jennifer P Wang, Luis Parra-Rodriguez, Tatyana Der, Kate Willsey, Jun Wen, Adam Silverstein, Sean M O'Brien, Hussein R Al-Khalidi, Michael A Maldonado, Richard Melsheimer, William G Ferguson, Steven E Mcnulty, Pearl Zakroysky, Susan Halabi, Daniel K Benjamin, Sandra Butler, Jane C Atkinson, Stacey J Adam, Soju Chang, Lisa Lavange, Michael Proschan, Samuel A Bozzette, William G Powderly, Activ-1 Im Study Group Members

Faculty, Staff and Student Publications

IMPORTANCE: Immune dysregulation contributes to poorer outcomes in COVID-19.

OBJECTIVE: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia.

DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-masked, placebo-controlled clinical trial using a master protocol to investigate immunomodulators added to standard care for treatment of participants hospitalized with COVID-19 pneumonia. The results of 3 substudies are reported from 95 hospitals at 85 clinical research sites in the US and Latin America. Hospitalized patients 18 years or older with confirmed SARS-CoV-2 infection within 14 days and evidence of pulmonary involvement underwent randomization between October 2020 and …


The Impact Of Geopolitical Risks On Price Variation And Political Trust In France: Analyzing The Ukraine-Russia Conflict, Olivier Sempiga Jul 2023

The Impact Of Geopolitical Risks On Price Variation And Political Trust In France: Analyzing The Ukraine-Russia Conflict, Olivier Sempiga

The Journal of International Relations, Peace Studies, and Development

Geopolitical risks (GPRs) have varied consequences over countries and over time. COVID-19 and the war in Ukraine are some of the recent GPRs. The conflict in Ukraine has had far-reaching economic consequences, not only for the countries directly involved in it but also for their trading partners and allies, and on the global economy in general. France, as one of Ukraine and Russia's major trading partners, has also felt the impact of the conflict on its economy. Using data from the French National Institute of Statistics and Economic Studies (INSEE), the paper investigates the impact of GPRs caused by the …


Mental Well-Being, Academic Experience, And Dropout Intention Among Counseling Students Affected By The Shift To Online Instruction During The Covid-19 Pandemic, Yusen Zhai, Mahmood Almaawali, Lindsey Bannish Jul 2023

Mental Well-Being, Academic Experience, And Dropout Intention Among Counseling Students Affected By The Shift To Online Instruction During The Covid-19 Pandemic, Yusen Zhai, Mahmood Almaawali, Lindsey Bannish

Journal of Technology in Counselor Education and Supervision

The COVID-19 pandemic has exacerbated challenges for many counseling students due to the threat of COVID-19 and the rapid shift to online learning, possibly resulting in increased mental health problems and dropout rates. This convergent mixed-methods study aimed to investigate the impact of COVID-19-related experiences and shift to online learning on (a) counseling students’ mental well-being, (b) academic experience, and (c) dropout intentions among a sample of 405 counseling students across 45 states. Path analysis results showed an excellent model fit (χ2 = 5.612, p = .47, CFI = 1.000, SRMR = .025, RMSEA = .000, 90% CI [.000, …


Cerebrovascular Disease In Covid-19., James E Siegler, Savanna Dasgupta, Mohamad Abdalkader, Mary Penckofer, Shadi Yaghi, Thanh N Nguyen Jul 2023

Cerebrovascular Disease In Covid-19., James E Siegler, Savanna Dasgupta, Mohamad Abdalkader, Mary Penckofer, Shadi Yaghi, Thanh N Nguyen

Cooper Medical School of Rowan University Departmental Research

Not in the history of transmissible illnesses has there been an infection as strongly associated with acute cerebrovascular disease as the novel human coronavirus SARS-CoV-2. While the risk of stroke has known associations with other viral infections, such as influenza and human immunodeficiency virus, the risk of ischemic and hemorrhagic stroke related to SARS-CoV-2 is unprecedented. Furthermore, the coronavirus disease 2019 (COVID-19) pandemic has so profoundly impacted psychosocial behaviors and modern medical care that we have witnessed shifts in epidemiology and have adapted our treatment practices to reduce transmission, address delayed diagnoses, and mitigate gaps in healthcare. In this narrative …


Covid-19: Variants, Immunity, And Therapeutics For Non-Hospitalized Patients., Cameron Y.S. Lee, Jon B. Suzuki Jul 2023

Covid-19: Variants, Immunity, And Therapeutics For Non-Hospitalized Patients., Cameron Y.S. Lee, Jon B. Suzuki

HPD Articles

The continuing transmission of coronavirus disease 2019 (COVID-19) remains a world-wide 21st-century public health emergency of concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused greater than 600 million cases of COVID-19 and over 6 million deaths globally. COVID-19 continues to be a highly transmissible disease despite efforts by public health officials and healthcare providers to manage and control the disease. Variants identified in selected worldwide epicenters add to the complexity of vaccine efficacy, overage, and antibody titer maintenance and bioactivity. The identification of the SARS-CoV-2 variants is described with respect to evading protective efficacy of COVID-19 vaccines and …


Media Literacy And Covid-19 Communication: Work And Home Sphere Differences, Donnalyn Pompper, Tugce Ertem-Eray Jul 2023

Media Literacy And Covid-19 Communication: Work And Home Sphere Differences, Donnalyn Pompper, Tugce Ertem-Eray

Journal of Media Literacy Education

As a learning process wherein we ask questions to enhance knowledge, media literacy offers a powerful lens for examining how people practice communication across diverse applied contexts such as professional communicators shaping messages about COVID-19. Borrowing a page from Renee Hobbs’ (1998, 1999, 2010, 2011, 2021) media literacy education research, we sought to compare/contrast media content creators’ (journalism, advertising, public relations, marketing communication) information-seeking behaviors during the 2020-2022 COVID-19 pandemic for both their paid work and unpaid volunteer work, as well as for their own and family edification. Blending the media literacy lens with social construction theory (Berger & Luckmann, …