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Building Research Capacity In Low- And Middle-Income Countries And Pandemic Preparedness: Lessons Learned And Future Directions, Peter H. Kilmarx, Karen A. Goralesk, Erum Khan, John F. Lindo, Nancy Gore Saravia

Department of Pathology and Laboratory Medicine

Research capacity is a critical component of pandemic preparedness, as highlighted by the challenges faced during the Ebola outbreak in West Africa. Recent global initiatives, such as the Research & Development Task Force of the Global Health Security Agenda and the World Health Assembly's resolution on strengthening clinical trials, emphasize the need for robust research capabilities. This Perspective discusses the experiences of leaders in infectious disease research and capacity building in low- and middle-income countries, focusing on Colombia, Jamaica, and Pakistan. These case studies underscore the importance of collaborative efforts, interdisciplinary training, and global partnerships in pandemic response. The experiences …

Virology-The Path Forward, Angela L Rasmussen, Gigi K Gronvall, Anice C Lowen, Felicia Goodrum, James Alwine, Kristian G Andersen, Simon J Anthony, Joel Baines, Arinjay Banerjee, Andrew J Broadbent, Christopher B Brooke, Samuel K Campos, Patrizia Caposio, Arturo Casadevall, Gary C Chan, Anna R Cliffe, Donna Collins-Mcmillen, Nancy Connell, Blossom Damania, Matthew D Daugherty, Kari Debbink, Terence S Dermody, Daniel Dimaio, W Paul Duprex, Michael Emerman, Denise A Galloway, Robert F Garry, Stephen A Goldstein, Alexander L Greninger, Amy L Hartman, Brenda G Hogue, Stacy M Horner, Peter J Hotez, Jae U Jung, Jeremy P Kamil, Stephanie M Karst, Lou Laimins, Seema S Lakdawala, Igor Landais, Michael Letko, Brett Lindenbach, Shan-Lu Liu, Micah Luftig, Grant Mcfadden, Andrew Mehle, Juliet Morrison, Anne Moscona, Elke Mühlberger, Joshua Munger, Karl Münger, Eain Murphy, Christopher J Neufeldt, Janko Z Nikolich, Christine M O'Connor, Andrew Pekosz, Sallie R Permar, Julie K Pfeiffer, Saskia V Popescu, John G Purdy, Vincent R Racaniello, Charles M Rice, Jonathan A Runstadler, Martin J Sapp, Rona S Scott, Gregory A Smith, Erin M Sorrell, Emily Speranza, Daniel Streblow, Scott A Tibbetts, Zsolt Toth, Koenraad Van Doorslaer, Susan R Weiss, Elizabeth A White, Timothy M White, Christiane E Wobus, Michael Worobey, Satoko Yamaoka, Andrew Yurochko

Faculty, Staff and Students Publications

In the United States (US), biosafety and biosecurity oversight of research on viruses is being reappraised. Safety in virology research is paramount and oversight frameworks should be reviewed periodically. Changes should be made with care, however, to avoid impeding science that is essential for rapidly reducing and responding to pandemic threats as well as addressing more common challenges caused by infectious diseases. Decades of research uniquely positioned the US to be able to respond to the COVID-19 crisis with astounding speed, delivering life-saving vaccines within a year of identifying the virus. We should embolden and empower this strength, which is …

Cross-Sectional And Descriptive Study On The Challenges And Awareness Of Hispanic Parents Regarding Their Adolescents’ Mental Health During The Covid-19 Pandemic, Jihye Kim, Robin Scott

Faculty Articles

Research has shown that during the COVID-19 pandemic, approximately 20% of children and adolescents in the United States experienced mental health issues that became a significant social concern. However, recent studies have demonstrated that the majority of adolescents maintain positive emotions despite the crisis. This cross-sectional and descriptive study delves into the emotional states of adolescents during the pandemic, considering the viewpoints of both adolescents and their parents, with a specific focus on Hispanic adolescents. Survey results revealed that most adolescents reported positive and happy moods. However, a percentage of adolescents experienced worry, significant changes in feelings, and loneliness as …

Employee Attitude As A Mediator Between Transformational Leadership Style And Employees’ Readiness To Change During Covid-19, Sania Khan

Information Sciences Letters

Early this decade, COVID-19 has wreaked havoc globally, which is compelling society and organizations to change. The Pandemic incident highlighted the significance of leadership style in influencing employee attitude and readiness to meet problems that have an impact on their daily tasks and performance. Consequently, this study is intended at finding the influence of transformational leaders on workers’ readiness to change during COVID-19 and how employee attitude mediates the relationship between both. The data was gathered from 386 participants using a standardized survey questionnaire. To explore the effect of transformational leadership on workers’ willingness to change and the significance of …

Equilibrium Points And Their Stability Of Covid-19 In Us, Xiaoxi Hu, Zixin Hu, Tao Xu, Kai Zhang, Henry H Lu, Jinying Zhao, Eric Boerwinkle, Li Jin, Momiao Xiong

Faculty, Staff and Student Publications

This study aims to develop an advanced mathematic model and investigate when and how will the COVID-19 in the US be evolved to endemic. We employed a nonlinear ordinary differential equations-based model to simulate COVID-19 transmission dynamics, factoring in vaccination efforts. Multi-stability analysis was performed on daily new infection data from January 12, 2021 to December 12, 2022 across 50 states in the US. Key indices such as eigenvalues and the basic reproduction number were utilized to evaluate stability and investigate how the pandemic COVD-19 will evolve to endemic in the US. The transmissional, recovery, vaccination rates, vaccination effectiveness, eigenvalues …

Real-World Dispensing Of Buprenorphine In California During Prepandemic And Pandemic Periods, Yun Wang, Alexandre Chan, Richard Beuttler, Marc L. Fleming, Todd Schneberk, Michael Nichol, Haibing Lu

Pharmacy Faculty Articles and Research

Introduction: The opioid overdose crisis in the United States has become a significant national emergency. Buprenorphine, a primary medication for individuals coping with opioid use disorder (OUD), presents promising pharmacokinetic properties for use in primary care settings, and is often delivered as a take-home therapy. The COVID-19 pandemic exacerbated the scarcity of access to buprenorphine, leading to dire consequences for those with OUD. Most existing studies, primarily focused on the immediate aftermath of the COVID-19 outbreak, highlight the challenges in accessing medications for opioid use disorder (MOUDs), particularly buprenorphine. However, these studies only cover a relatively short timeframe. Methods: To …

Knowledge, Attitudes, And Subjective Norms Associated With Covid-19 Vaccination Among Pregnant Women In Kenya: An Online Cross-Sectional Pilot Study Using Whatsapp, Sylvia Ayieko, Walter Jaoko, Rose Okoyo Opiyo, Elkanah Omenge Orang'o, Sarah E Messiah, Kimberly Baker, Christine Markham

Faculty, Staff and Student Publications

COVID-19 vaccination during pregnancy has been recommended, but the perceptions related to uptake remain unexplored. This pilot study aimed to explore how perceptions influence COVID-19 vaccine uptake among a sample of 115 pregnant women in Kenya, recruited via WhatsApp. Data were collected using an adapted online questionnaire between May and October 2022. Logistic analyses assessed the relationship between COVID-19 vaccination uptake and the Theory of Reasoned Action (TRA) constructs: attitudes and subjective norms. COVID-19 vaccination coverage was 73%, with vaccine hesitancy estimated at 41.4% among the unvaccinated group. Most participants had completed college education and had good knowledge of COVID-19 …

Coagulopathy In Severe Covid-19 Patients: Causes, Concerns And Current Treatment Regimen, Tanusree Sengupta, Arun Luiz, Chennakesavan Suganthi, Samarpan Majumder

School of Graduate Studies Faculty Publications

Elevated D-dimer and fibrinogen level, mild thrombocytopenia, modest prolongation of prothrombin time, and activated partial thromboplastin time, are key indicators of coagulopathy, and have been consistently reported in severely ill COVID-19 patients. Coronavirus disease 2019 (COVID-19)-induced coagulopathy can develop serious venous and arterial thromboembolic complications. Endothelial dysfunction and hypercoagulability, triggered mostly by overproduction of inflammatory cytokines as an immune response to the infection, are the pivotal factors responsible for the above-mentioned coagulation disorder. Thus, low-molecular-weight heparin (LMWH), which has both anticoagulant and anti-inflammatory properties, has been reported to improve disease prognosis. However, there have been increasing reports of venous thromboembolic …

Eleven-Year-Old Child With Covid-19 Induced Long Segment Transverse Myelitis, Basim A. Alhijaj, Zainab Adel, Ahmed A. Salim

Iraqi National Journal of Medicine

Transverse myelitis (TM) is a clinical syndrome characterized by sensory, motor, and autonomic dysfunctions resulting from immune-mediated spinal cord injury. A possible association between COVID-19 and TM has been recognized. This paper examines the case of an eleven-year-old child who presented with paraplegia and urine retention and was evaluated carefully by a multidisciplinary team comprising a neurophysiologist, a pediatrician, and a neurologist. Sequentially, EMG, NCS, magnetic resonance T2 was conducted to reach the diagnosis of transverse myelitis. The patient was treated with bullous methylprednisolone for three days and showed steady and complete clinical and neurophysiological improvement.

Serological Survey To Detect Antigens That Cross-React With Covid-19 Antibodies, Ahmed N. Mnahi, Abdulelah A. Almyah, Zuhair Al-Shaheen

Iraqi National Journal of Medicine

Background: COVID-19 first emerged in Wuhan City and has since spread worldwide, infecting over 600 million people. The World Health Organization (WHO) issued an emergency in public health in January 2020 due to reports of new coronaviruses in Europe, Asia, and the Americas. Aim: The study aims to screen bacterial antigens for cross-reactivity with COVID-19 antibodies using indirect ELISA and to detect cross-reactivity between vaccinated and unvaccinated healthy individuals and various bacterial types (Gammaproteobacteria, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, and Enterobacteria, in addition to Staphylococcus aureus) either sonicated or non-sonicated. Methods: ELISA is a method for detecting unknown samples …

Moral Mobilization In The Digital Space: Seafarers Exercising Agency During The Pandemic, Lijun Tang

Plymouth Business School

The agency of casualized and spatially isolated workers has recently received increased research attention. This paper extends this line of research to seafarers, a traditional but also casualized and spatially isolated workforce. More specifically, it examines cases of collective action by Chinese seafarers on WeChat, a social media platform, in response to problems and grievances caused by COVID-19 control measures during the pandemic. It shows that seafarers, building on the WeChat platform and together with other maritime stakeholders, have established a socio-technological infrastructure that enables them to mobilize their peers to take action when they experience injustice at work. Their …

Covid-19 Convalescent Plasma Therapy Decreases Inflammatory Cytokines: A Randomized Controlled Trial, Feben Habtehyimer, Xianming Zhu, Andrew D Redd, Kelly A Gebo, Alison G Abraham, Eshan U Patel, Oliver Laeyendecker, Thomas J Gniadek, Reinaldo E Fernandez, Owen R Baker, Malathi Ram, Edward R Cachay, Judith S Currier, Yuriko Fukuta, Jonathan M Gerber, Sonya L Heath, Barry Meisenberg, Moises A Huaman, Adam C Levine, Aarthi Shenoy, Shweta Anjan, Janis E Blair, Daniel Cruser, Donald N Forthal, Laura L Hammitt, Seble Kassaye, Giselle S Mosnaim, Bela Patel, James H Paxton, Jay S Raval, Catherine G Sutcliffe, Matthew Abinante, Kevin S Oei, Valerie Cluzet, Marie Elena Cordisco, Benjamin Greenblatt, William Rausch, David Shade, Amy L Gawad, Sabra L Klein, Andrew Pekosz, Shmuel Shoham, Arturo Casadevall, Evan M Bloch, Daniel Hanley, Aaron A R Tobian, David J Sullivan

Faculty, Staff and Student Publications

This study examined the role that cytokines may have played in the beneficial outcomes found when outpatient individuals infected with SARS-CoV-2 were transfused with COVID-19 convalescent plasma (CCP) early in their infection. We found that the pro-inflammatory cytokine IL-6 decreased significantly faster in patients treated early with CCP. Participants with COVID-19 treated with CCP later in the infection did not have the same effect. This decrease in IL-6 levels after early CCP treatment suggests a possible role of inflammation in COVID-19 progression. The evidence of IL-6 involvement brings insight into the possible mechanisms involved in CCP treatment mitigating SARS-CoV-2 severity.

Evaluation Of Colorimetric Rt-Lamp For Screening Of Sars-Cov-2 In Untreated Wastewater, Jesmin Akter, Wendy J.M. Smith, Metasebia Gebrewold, Ilho Kim, Stuart L. Simpson, Aaron Bivins, Warish Ahmed

Faculty Publications

This study compared reverse transcription-loop-mediated isothermal amplification (RT-LAMP) and three reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays targeting the N and E genes of the SARS-CoV-2 genome for detecting RNA in untreated wastewater samples. RT-qPCR assays exhibited consistent amplification down to 2 × 102 GC/reaction, with greater analytical sensitivity at 2 × 101 GC/reaction by US CDC N1 and US CDC N2 assays. In contrast, RT-LAMP exhibited lower sensitivity, detecting SARS-CoV-2 only at or above 2 × 103 GC/reaction. For SARS-CoV-2 seeded wastewater samples, the US CDC N1 assay exhibited greater analytical sensitivity than the US CDC N2, E_Sarbeco, and …

Waiving Snap Interviews During The Covid-19 Pandemic Increased Snap Caseloads, Colleen Heflin, William Clay Fannin, Leonard M. Lopoo, Siobhan O'Keefe

Center for Policy Research

Food insecurity in the United States reached historically high rates during the COVID-19 pandemic, thus substantially increasing demand for the Supplemental Nutrition Assistance Program (SNAP). To facilitate access to SNAP during the pandemic, the federal government granted state SNAP offices the option to waive the interview requirement – an administrative burden associated with the SNAP certification process. This brief summarizes findings from a recent study that used data from SNAP offices across 10 states to examine the impact of SNAP interview waivers on SNAP caseloads from January 5th to April 30th of 2021. Findings reveal that counties that implemented the …

Cost-Effectiveness Analysis Of Favipiravir And Remdesivir As Covid-19 Treatment In South Tangerang, Banten Province - Indonesia, Wahyu G. Putro, Andriani R. Fahriyati, Gilberto A. Julian, Tania R. Amalia, Zaki M. Riski

Pharmacology and Clinical Pharmacy Research

COVID-19 is a contagious ailment primarily attributed to the severe acute respiratory syndrome coronavirus. Indonesia persists in confronting the COVID-19 pandemic, and South Tangerang City has emerged as one of the municipalities in Indonesia that has been significantly affected. There are two categories of medications employed for COVID-19 treatment according to government policies, namely favipiravir and remdesivir. This study aims to as- sess the cost-effectiveness of favipiravir and remdesivir medications at the South Tangerang General Hospital, Indonesia. The present study employs a retrospective research design characterized by a quantitative approach, utilizing cross-sectional methodologies. The analy- sis mostly consists of descriptive …

Impact Of The Increased Use Of Telehealth On Health Care Management And Administration: The Case Of New Care Management Practices, Immacula Pierre

Doctoral Dissertations and Projects

The COVID-19 pandemic has brought unprecedented challenges to healthcare systems worldwide, forcing them to adapt and implement alternative modes of healthcare delivery quickly. Telehealth, the delivery of healthcare services through telecommunication technologies, has become crucial in providing continuous care while reducing the risk of virus transmission. This qualitative study aimed to explore healthcare managers' perceptions of the use of telehealth and its impact on healthcare practices during the pandemic, particularly in terms of provision and quality control. A purposive sample of 10 healthcare managers from different healthcare settings in the United States participated in semi-structured interviews conducted via video conferencing. …

The Unprecedented Stressors Of Early Childhood Educators During The Covid-19 Pandemic And Post-Pandemic Restoration: A Case Study, Ida Mae Lewis

Doctoral Dissertations and Projects

The purpose of this case study was to describe the unprecedented stressors of early childhood educators (ECE) during the COVID-19 pandemic and the post-pandemic restoration at two early childhood education centers (ECEC) in a midwestern state. The central research question was: How did the COVID-19 pandemic’s unprecedented stressors impact ECE in the post-pandemic era? Data collection included structured interviews with open-ended questions, focus groups, and documents. The three data sources were triangulated for themes, perspectives, and interpretations, and coding was used to help gain a deep understanding of the stressors experienced by early childhood educators. The conceptual framework guiding this …

Assessing Covid-Related Concerns And Their Impact On Antenatal And Delivery Care Among Pregnant Women Living With Hiv In Kenya: A Brief Report., Catherine Wexler, May Maloba, Sharon Mokua, Shadrack Babu, Nicodemus Maosa, Vincent Staggs, Kathy Goggin, Harshdeep Acharya, Emily A. Hurley, Sarah Finocchario-Kessler

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Some studies indicate that pregnant Kenyan women were concerned about Coronavirus disease 2019 (COVID-19) exposure during maternity care. We assessed concern regarding COVID-19 exposure and any impact on antenatal care (ANC) enrollment and/or hospital delivery among pregnant women living with human immunodeficiency virus (HIV) in Kenya.

METHODS: Data were collected from 1,478 pregnant women living with HIV enrolled in prevention of mother to child transmission of HIV (PMTCT) care at 12 Kenyan hospitals from October 2020 to July 2022. Surveys were conducted when women first presented for PMTCT services at the study hospital and asked demographic questions as well …

Systemic Racism And Covid-19: Vulnerabilities With The U.S. Social Safety Net For Immigrants And People Of Color, Adam M. Butz, Jason E. Kehrberg

Journal of Public Management & Social Policy

America has a mythologized reputation as an accommodative “melting pot” nation that welcomes individuals from all races and countries seeking improved quality of life and reduced material hardship. However, our U.S. social welfare system is more broadly characterized as underdeveloped, restrictive, and exclusionary, especially toward immigrants and people of color. Public health benefits (e.g., Medicaid), food assistance programs (e.g., SNAP), rental assistance (e.g., HCV/Section 8), and cash assistance (e.g., TANF) are oftentimes restricted for immigrants and racial minorities, making them more vulnerable to material hardship and more exposed to pandemic conditions under COVID-19. Moreover, these welfare restrictions are oftentimes rooted …

Fitting A Covid-19 Model Incorporating Senses Of Safety And Caution To Local Data From Spartanburg County, South Carolina, D. Chloe Griffin, Amanda Mangum

CODEE Journal

Common mechanistic models include Susceptible-Infected-Removed (SIR) and Susceptible-Exposed-Infected-Removed (SEIR) models. These models in their basic forms have generally failed to capture the nature of the COVID-19 pandemic's multiple waves and do not take into account public policies such as social distancing, mask mandates, and the ``Stay-at-Home'' orders implemented in early 2020. While the Susceptible-Vaccinated-Infected-Recovered-Deceased (SVIRD) model only adds two more compartments to the SIR model, the inclusion of time-dependent parameters allows for the model to better capture the first two waves of the COVID-19 pandemic when surveillance testing was common practice for a large portion of the population. We find …

Features Of Acute Covid-19 Associated With Post-Acute Sequelae Of Sars-Cov-2 Phenotypes: Results From The Impacc Study, Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E Milliren, Jingjing Qi, Linda N Geng, Grace A Mccomsey, Charles B Cairns, Lindsey R Baden, Joanna Schaenman, Albert C Shaw, Hady Samaha, Vicki Seyfert-Margolis, Florian Krammer, Lindsey B Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P Shannon, Rafick P Sekaly, Lauren I R Ehrlich, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Harm Van Bakel, Seunghee Kim-Schulze, David A Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K Haddad, Carolyn S Calfee, David J Erle, Charles R Langelier, Walter Eckalbar, Steven E Bosinger, Bjoern Peters, Steven H Kleinstein, Elaine F Reed, Alison D Augustine, Joann Diray-Arce, Holden T Maecker, Matthew C Altman, Ruth R Montgomery, Patrice M Becker, Nadine Rouphael

Faculty, Staff and Students Publications

Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B …

Effect Of Anti-Interleukin-6 Agents On Psychopathology In A Sample Of Patients With Post-Covid-19 Syndrome: An Observational Study, Alessio Simonetti, Antonio Restaino, Evelina Bernardi, Ottavia Marianna Ferrara, Stella Margoni, Antonio Maria D'Onofrio, Federica Ranieri, Delfina Janiri, Vincenzo Galluzzo, Matteo Tosato, Georgios D Kotzalidis, Francesco Landi, Gabriele Sani

Faculty, Staff and Students Publications

Interleukin 6 (IL-6) receptor inhibitors tocilizumab and sarilumab have recently been approved for severe coronavirus disease 2019 (COVID-19). They also affect mood, even though their effect on the post-COVID-19 syndrome-related psychopathology still has to be investigated. The aim of this study was to investigate their effect on psychopathology in a sample of patients with post-COVID-19 syndrome. We included 246 patients (34% female, 66% male) aged 18–75 years who had been hospitalized for COVID. Patients were split into those who received anti-IL-6 receptor agents (Anti-IL-6-R, N = 88) and those who did not (Ctrl, N = 158). The former group was …

Inpatient Costs Of Treating Patients With Covid-19, Kandice A Kapinos, Richard M Peters, Robert E Murphy, Samuel F Hohmann, Ankita Podichetty, Raymond S Greenberg

Faculty, Staff and Student Publications

IMPORTANCE: With more than 6.2 million hospitalizations due to COVID-19 in the US, recognition of the average hospital costs to provide inpatient care during the pandemic is necessary to understanding the national medical resource use and improving public health readiness and related policies.

OBJECTIVE: To examine the mean cost to provide inpatient care to treat COVID-19 and how it varied through the pandemic waves and by important sociodemographic patient characteristics.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used inpatient-level data from March 1, 2020, to March 31, 2022, extracted from a repository of clinical, administrative, and financial information covering 97% …

Collateral Effects Of Covid-19 Stay-At-Home Orders On Violence Against Women In The United States, January 2019 To December 2020, Patricia C. Lewis, Yuk F. Cheong, Nadine J. Kaslow, Kathryn M. Yount

Health Science Faculty Publications

Background: The necessary execution of non-pharmaceutical risk-mitigation (NPRM) strategies to reduce the transmission of COVID-19 has created an unprecedented natural experiment to ascertain whether pandemic-induced social-policy interventions may elevate collateral health risks. Here, we assess the efects on violence against women (VAW) of the duration of NPRM measures that were executed through jurisdictional-level orders in the United States. We expect that stay-at-home orders, by reducing mobility and disrupting non-coresident social ties, are associated with higher incident reporting of VAW.

Methods: We used aggregate data from the Murder Accountability Project from January 2019 through December 2020, to estimate count models examining …

Integrated Multi-Omics Analyses Identify Anti-Viral Host Factors And Pathways Controlling Sars-Cov-2 Infection, Jiakai Hou, Yanjun Wei, Jing Zou, Roshni Jaffery, Long Sun, Shaoheng Liang, Ningbo Zheng, Ashley M Guerrero, Nicholas A Egan, Ritu Bohat, Si Chen, Caishang Zheng, Xiaobo Mao, S Stephen Yi, Ken Chen, Daniel J Mcgrail, Nidhi Sahni, Pei-Yong Shi, Yiwen Chen, Xuping Xie, Weiyi Peng

Faculty, Staff and Student Publications

Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout screen and integrate analyses of the multi-omics data of the CRISPR screen, genome-wide association studies, single-cell RNA-Seq, and host-virus proteins or protein/RNA interactome. This study uncovers many host factors that are currently underappreciated, including the components of V-ATPases, ESCRT, and N-glycosylation pathways that modulate viral entry and/or replication. The cohesin complex is also identified as an anti-viral pathway, suggesting an important role of …

Labour Force Participation And Type Of Work Older Persons In Vietnam Before And During Covid-19, Trieu Thi Phuong, Pataporn Sukontamarn

Journal of Demography

Vietnam is ageing rapidly and is predicted to enter an aged society within the next fifteen years, posing a major challenge for a lower middle-income nation with an incomplete social security system. Supporting older persons to continue working can be a reasonable strategy to ensure their life quality and reduce the burden on the national social security system. Our study aims to investigate the determinants of older persons’ participation in the labour force and their type of work. Based on the 2018 and 2020 Vietnam Housing and Living Standard surveys, health problems, pension status, and level of education significantly explain …

The Impact Of Loneliness Post-Pandemic And Immersed In The Upcoming Political Election, Regina M. Luttrell Ph.D., Gwen Pratt, Abigail Kludt, Amy Barone, Kwadwo Osei-Poku, Lihan Wang

Real Chemistry Emerging Insights Lab

The Real Chemistry Emerging Insights Lab emerged with a partnership between Real Chemistry and the Public Relations department at the S.I. Newhouse School of Public Communication and serves as a multidisciplinary research center focusing on analytics, artificial intelligence, digital and emerging media for a number of organizations regarding communications.

Healthcare professionals and organizations are interested in identifying how mental health impacts different U.S. generational groups after the COVID-19 pandemic and the intersectionality of U.S. Politics. Our team focused on two generational cohorts – Generation X (1965-1980) and Generation Z (1997-2012) – as an entry point into navigating the impact of …

“It’S The End Of The World As We Know It” –Redrafting Amendment To Federal Rule Of Criminal Procedure 26 To Allow Remote Testimony, Alisson Sandoval

Touro Law Review

During the COVID-19 pandemic, when society fought an aggressive and deadly virus, our connection to the outside world became predominantly virtual. Videoconference technology became essential in state and federal civil judicial proceedings. In light of the unprecedented challenges presented by the pandemic and its long-lasting impact on the criminal justice system, this Article argues for amending Federal Rule of Criminal Procedure 26 to permit remote witness testimony when a witness is unavailable.

Time Series Forecasting Of New Cases For Covid-19 Pandemic In Jordan Using Enhanced Hybrid Emd-Arima, Ahmad M. Awajan, Bilal Al-Hasanat, Elarbi Elkaroui, Ayed Al E’Damat, Remal S. Al-Gounmeein, Abdullah S. Al- Jawarneh

Journal of Statistics Applications & Probability

In this study, the enhanced hybrid empirical mode decomposition with autoregressive integrated moving average (EMD- ARIMA) method is proposed and applied to forecast daily new COVID-19 reported cases in Jordan. The EMD method is applied to decompose the COVID-19 data into a number of IMFs components as a simple time series. Then, the appropriate ARIMA(p,d,q) model is applied to evaluate the forecasting value for the low-frequency components. Then, the forecasting results are collected together. Data for this study are collected from the Jordanian Ministry of Health. Seven forecasting accuracy measures are employed to compare the forecasting results of the proposed …

Introducing Mental Health Resources To Nurse Practitioner Residents, Tiffanie Bailey

Doctor of Nursing Practice Projects

This DNP Project identified the increased need for mental health resources after the COVID-19 pandemic. Studies showed the rate of anxiety, depression, and substance use has also been on the rise since the beginning of the pandemic. As the impact of the COVID-19 pandemic began to devastate the country mentally and physically, it became quickly apparent that additional resources to provide support for those suffering from mental illness were essential. This project aimed to introduce a Mental Health First Aid course within the Residency Program at the Center for Family Guidance. Participants were asked to complete a pre-test indicating their …