Digital Commons Network^™

The Association Between Prolonged Sars-Cov-2 Symptoms And Work Outcomes, Arjun K Venkatesh, Huihui Yu, Caitlin Malicki, Michael Gottlieb, Joann G Elmore, Mandy J Hill, Ahamed H Idris, Juan Carlos C Montoy, Kelli N O'Laughlin, Kristin L. Rising, Kari A Stephens, Erica S Spatz, Robert A Weinstein

Department of Emergency Medicine Faculty Papers

While the early effects of the COVID-19 pandemic on the United States labor market are well-established, less is known about the long-term impact of SARS-CoV-2 infection and Long COVID on employment. To address this gap, we analyzed self-reported data from a prospective, national cohort study to estimate the effects of SARS-CoV-2 symptoms at three months post-infection on missed workdays and return to work. The analysis included 2,939 adults in the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE) study who tested positive for their initial SARS-CoV-2 infection at the time of enrollment, were employed before the pandemic, and completed …

Collegiate Student-Athlete Responses To The Covid-19 Pandemic, Alexa Jenny Chandler

Theses and Dissertations

Introduction: Exercise imposes a physiological stressor on the body which is amplified as training intensifies. Collegiate fall-sport student-athletes return after summer break (off-season) and have approximately two weeks of training (preseason) with coaching staff before competition begins. The 2020 fall season was preceded by a five-month period away from campus due to the timing of the coronavirus 2019 (COVID-19) pandemic. This also meant all commercial gyms and training facilities were closed, and student-athletes were forced to train with the resources they had at home. Upon return to campus, significant changes were made to practice and competition structures in attempt to …

Outcomes Of The Emdataresource Cryo-Em Ligand Modeling Challenge, Catherine L Lawson, Andriy Kryshtafovych, Grigore D Pintilie, Stephen K Burley, Jiří Černý, Vincent B Chen, Paul Emsley, Alberto Gobbi, Andrzej Joachimiak, Sigrid Noreng, Michael G Prisant, Randy J Read, Jane S Richardson, Alexis L Rohou, Bohdan Schneider, Benjamin D Sellers, Chenghua Shao, Elizabeth Sourial, Chris I Williams, Christopher J Williams, Ying Yang, Venkat Abbaraju, Pavel V Afonine, Matthew L Baker, Paul S Bond, Tom L Blundell, Tom Burnley, Arthur Campbell, Renzhi Cao, Jianlin Cheng, Grzegorz Chojnowski, K D Cowtan, Frank Dimaio, Reza Esmaeeli, Nabin Giri, Helmut Grubmüller, Soon Wen Hoh, Jie Hou, Corey F Hryc, Carola Hunte, Maxim Igaev, Agnel P Joseph, Wei-Chun Kao, Daisuke Kihara, Dilip Kumar, Lijun Lang, Sean Lin, Sai R Maddhuri Venkata Subramaniya, Sumit Mittal, Arup Mondal, Nigel W Moriarty, Andrew Muenks, Garib N Murshudov, Robert A Nicholls, Mateusz Olek, Colin M Palmer, Alberto Perez, Emmi Pohjolainen, Karunakar R Pothula, Christopher N Rowley, Daipayan Sarkar, Luisa U Schäfer, Christopher J Schlicksup, Gunnar F Schröder, Mrinal Shekhar, Dong Si, Abhishek Singharoy, Oleg V Sobolev, Genki Terashi, Andrea C Vaiana, Sundeep C Vedithi, Jacob Verburgt, Xiao Wang, Rangana Warshamanage, Martyn D Winn, Simone Weyand, Keitaro Yamashita, Minglei Zhao, Michael F Schmid, Helen M Berman, Wah Chiu

Children’s Nutrition Research Center Staff Publications

The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein-nucleic acid complexes in cryogenic electron microscopy (cryo-EM) maps determined at near-atomic (1.9-2.5 Å) resolution. Three published maps were selected as targets: Escherichia coli beta-galactosidase with inhibitor, SARS-CoV-2 virus RNA-dependent RNA polymerase with covalently bound nucleotide analog and SARS-CoV-2 virus ion channel ORF3a with bound lipid. Sixty-one models were submitted from 17 independent research groups, each with supporting workflow details. The quality of submitted ligand models and surrounding atoms were analyzed by visual inspection and quantification of local map quality, model-to-map …

Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation In Melanoma: Impact Of Antibiotic Preconditioning On Microbiome And Immunity, Isabella C Glitza, Yongwoo David Seo, Christine N Spencer, Jennifer R Wortman, Elizabeth M Burton, Farah A Alayli, Christopher P Loo, Shikha Gautam, Ashish Damania, Julie Densmore, Justin Fairchild, Christopher R Cabanski, Matthew C Wong, Christine B Peterson, Brian Weiner, Nathan Hicks, John Aunins, Christopher Mcchalicher, Emily Walsh, Michael T Tetzlaff, Omid Hamid, Patrick A Ott, Genevieve M Boland, Ryan J Sullivan, Kenneth F Grossmann, Nadim J Ajami, Theresa Lavallee, Matthew R Henn, Hussein A Tawbi, Jennifer A Wargo

Faculty, Staff and Student Publications

Gut-microbiota modulation shows promise in improving immune-checkpoint blockade (ICB) response; however, precision biomarker-driven, placebo-controlled trials are lacking. We performed a multicenter, randomized placebo-controlled, biomarker-stratified phase I trial in patients with ICB-naïve metastatic melanoma using SER-401, an orally delivered Firmicutesenriched spore formulation. Fecal microbiota signatures were characterized at baseline; patients were stratified by high versus low Ruminococcaceae abundance prior to randomization to the SER-401 arm (oral vancomycin-preconditioning/SER-401 alone/nivolumab + SER-401), versus the placebo arm [placebo antibiotic/placebo microbiome modulation (PMM)/nivolumab + PMM (NCT03817125)]. Analysis of 14 accrued patients demonstrated that treatment with SER-401 + nivolumab was safe, with an overall response rate …

Hubungan Komorbiditas Terhadap Kondisi Akhir Pasien Covid-19 Di Rsud Siti Fatimah Provinsi Sumatera Selatan, Dewie Suranti

Jurnal Epidemiologi Kesehatan Indonesia

Pada tahun 2021, Indonesia menempati peringkat pertama dengan kasus COVID-19 terbanyak di ASEAN. Angka kematian COVID-19 di Indonesia sebesar 3,4% dan peringkat ke-5 ditempati oleh Provinsi Sumatera Selatan. Penelitian terdahulu menunjukkan komorbiditas berkontribusi terhadap kematian pasien COVID-19 disertai usia dan jenis kelamin. Penelitian ini bertujuan untuk menganalisis peran usia, jenis kelamin, dan komorbiditas terhadap kondisi akhir pasien COVID-19 di RSUD Siti Fatimah. Metode penelitian menggunakan desain cohort retrospective dengan analisis cox regression pendekatan model proportional hazard. Penelitian ini menggunakan data sekunder yaitu rekam medik pasien terkonfirmasi COVID-19 di RSUD Siti Fatimah dari Januari-Desember 2021 berjumlah 928 pasien yang diambil dengan …

What Are The Lessons Learned From A Survivorship Trial During The Pandemic?, Alanna J. Horowitz, Sharneet J. Sandhu, Sherry J. Guo, Gabriel Barreto-D'Silva, Leonardo Barreto-D'Silva, Krishna Gunturu

The Lahey Journal

Purpose: The American Cancer Society (ACS) has acknowledged the importance of maintaining a healthy diet and engaging in regular physical activity for cancer survivors. While studies have found that adherence to these guidelines improves long-term quality of life, several studies showed that up to 70% of cancer survivors do not meet the standards. The purpose of this pilot study is to determine the effectiveness of a multi-disciplinary survivorship clinic (MDSC) in helping patients adhere to the ACS survivorship guidelines and its impacts on quality of life (QOL).

Methods: Primary objective of the study is to encourage cancer patients to adhere …

Supporting Ontario Public Health Units To Address Adverse Childhood Experiences In Pandemic Recovery Planning: A Priority-Setting Exercise, Kimberly B Harding, Erica Di Ruggiero, Erick Gonzalez, Amanda Hicks, Daniel W Harrington, Sarah Carsley

Faculty, Staff and Student Publications

BACKGROUND: Adverse childhood experiences (ACEs) are potentially traumatic exposures experienced during childhood, for example, neglect. There is growing evidence that the coronavirus disease 2019 (COVID-19) pandemic and related socioeconomic conditions contributed to an increased risk of ACEs. As public health programs/services are re-evaluated and restored following the state of emergency, it is important to plan using an ACEs-informed lens. The aim of this study was to identify and prioritize initiatives or activities that Public Health Ontario (PHO) could undertake to support Ontario public health units' work towards ACEs-informed pandemic recovery plans.

METHODS: The Child Health and Nutrition Research Initiative method …

Climate Regulation And Co-Benefits: The Reality Of Co-Benefits In Climate Policy And The Reality We Face Without Them, Riley Jacobs

San Diego Journal of Climate & Energy Law

The United States has long required administrative agencies to conduct Cost-Benefit Analyses (“CBA”) in their rulemaking. By conducting CBA, agencies “show their work” to Congress, courts, and constituencies as to why the agency wishes to regulate a certain way and what it would cost to do so.

This Article will focus on co-benefits, an increasingly divisive component of CBA. Co-benefits, or benefits occurring secondary to the targeted purpose of statutory authority, assist agencies like the Environmental Protection Agency (“EPA”) in painting a holistic picture of everything the public has to gain from a rule’s passage. In recognizing that value, the …

Strengthening U.S. Jail Systems’ Response To Infectious Diseases: An Evaluation Of The Covid-19 Pandemic, Erinn Bacchus

Dissertations and Theses

Jails across the United States were struck with increased infections and deaths during the COVID-19 pandemic. Studies have shown the structural make up of jails, lack of preparedness plans, and overcrowding contributed to health risks and poor health outcomes both inside jails and local communities. Yet little research has been dedicated to strengthening jail responses to infectious disease outbreaks spanning prevention measures, data collection, and reentry planning. Gaps include information on the (1) myriad infectious disease mitigation strategies used in jails and adherence to CDC prevention guidelines, (2) development of a standardized epidemiologic surveillance system, and (3) experiences working at …

The Communal Table: A Wholistic Perspective On Food And Social Development, Sarah Cook

Masters Theses

In order to address issues of isolation in the wake of a global pandemic, this thesis examines the nature of the connection between food and community through commensality. “Commensality” is defined as the practice of eating together, which has demonstrable health benefits on personal, interpersonal, and psychological levels. Research reveals that, while commensality has been a foundational tenet of society since civilization’s beginnings, instances of commensality appear to be at an all time low for modern Americans. The results are diminished mental health, undeveloped support networks, and missed opportunities for emotional connection. All of these may be thought of as …

The Cure For World Peace: A Public Health Strategy, Eva Eleftheriadis

Undergraduate Honors Theses

Health and the environment impact the security and stability of the global community, as can be seen through the effects of pandemics and climate change. This paper attempts to address these factors by helping create a preventative strategy for countries to be better equipped to face these challenges, and decrease the extent of future manifestations. Starting with a comparative analysis of the Black Death and the COVID-19 pandemic, this paper explores the relationship that exists between health, the environment, and human behavior. The analysis suggests that when these aspects are mutually beneficial, there is an increase in human security, which …

Lemons To Lemonade: Educational Modifications During The Covid-19 Pandemic And Their Utility Moving Forward, Ellis S. Logan, Brandon Atkins, Anne M. Price

The Journal of Public and Professional Sociology

The COVID-19 pandemic necessitated changes across social institutions, including education. This case study outlines specific innovations using five cases of pedagogical developments made by social science faculty members at a public university, and their utility for undergraduate students in a post-pandemic world. These innovations relate specifically to office hour scheduling, class assignment reminders, building informal class support groups, experiential learning, and virtual paper submission and evaluation. For each case, we outline the implementation procedure, evaluate its effectiveness, and discuss the benefits. We argue that these methods, forged during “challenging times”, will help improve students’ experiences and success during their time …

The Experience Of University Academics With Emergency Remote Teaching During The Covid-19 Pandemic Of 2020: A Phenomenological Study, Judith M. Peterson

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore the experiences of academics at the university level with emergency remote teaching during the 2020-2021 COVID-19 pandemic. The theory guiding this study was Milheim, K. L. (2012) application of Maslow, A. H. (1943) hierarchy of needs. The central research question was: How did academics at the university level experience transitioning their course and teaching online during emergency remote teaching during the COVID-19 pandemic of 2020-2021? Eleven lecture academics were selected from six universities from the University of Wisconsin System who transitioned their residence courses to online during the pandemic. I …

Charting The Covid Long Haul Experience - A Longitudinal Exploration Of Symptoms, Activity, And Clinical Adherence, Jessica Pater, Shaan Chopra, Jeanee Carroll, Juliette Zaccour, Fayika Farhat Nova, Tammy Toscos, Shion Guha Ms, Phd, Fenlei Chang Md, Phd

Health Services and Informatics Research

COVID Long Haul (CLH) is an emerging chronic illness with varied patient experiences. Our understanding of CLH is often limited to data from electronic health records (EHRs), such as diagnoses or problem lists, which do not capture the volatility and severity of symptoms or their impact. To better understand the unique presentation of CLH, we conducted a 3-month long cohort study with 14 CLH patients, collecting objective (EHR, daily Fitbit logs) and subjective (weekly surveys, interviews) data. Our findings reveal a complex presentation of symptoms, associated uncertainty, and the ensuing impact CLH has on patients’ personal and professional lives. We …

Thoughts, Conflicts, And Feelings Of Ela Teachers’ Experiences During The Covid-19 Pandemic, Matthew Osborn

Dissertations

The COVID-19 pandemic introduced many complications and challenges for educators. There is a need to document and describe teacher experiences during this time to determine common themes that may inform future educational practice. This study utilized narrative inquiry to examine the lived experiences of five secondary ELA teachers during the different phases of the COVID-19 pandemic. Three themes concerning how teachers perceived their students, work demands, and self were identified through several rounds of coding and thematic analysis. The findings and conclusions of this study contribute to developing a shared understanding of what happened in secondary education during the various …

Pandemic Pandemonium: The Interconnectedness Of Environmental And Public Health Through The Lens Of Covid-19, Hanna Giedraitis

Student Theses 2015-Present

In 2020, the world was launched into a global pandemic it was completely unprepared to fight. This pandemic began in the midst of tragic environmental disasters, including the largest wildfire recorded in California history. Once the global lockdown began, many long-standing environmental problems began to remedy themselves due to the sudden halt of human interaction. However, there were major environmental setbacks in the healthcare industry as increased medical waste and single-use items became a necessity. This thesis addresses how the pandemic impacted the environment through a lens of sustainability and public health, and how healthcare industries can be more prepared …

Measuring Standard Of Care Physical Parameters In An Academic Psychiatric Practice During The Covid Pandemic – A Trainee Driven Quality Improvement Study, Himangshu Rathinakumar, Md, James Luebbert, Md

Health Equity and Quality Improvement (HEQI) Summit

Background

• Outpatient Psychiatric services need to monitor certain evidence-based quality indicators that promote patient safety and guide standards of care.
• Our Child and Adolescent Psychiatry (CAP) fellow outpatient clinic provides psychotherapy and pharmacological management to a population in a major metropolitan city, who belong to various minority predominantly African American and reduced socio-economic at-risk groups.
• The COVID pandemic has brought about a lot of changes in psychiatric practice which includes Telepsychiatry.
• This study aims to determine if greater use of telepsychiatry has resulted in changes in compliance with the evaluation of basic vital sign parameters of our patients during the …

Investigating Risk Factors Contributing To The High Incidence Of Covid-19 Among The Diné People Of The Navajo Nation, Elizabeth Lila Reynolds

Rowan-Virtua Research Day

Background: COVID-19 became international news in December 2019 and subsequently impacted global health. The research shows that the Diné people of the Navajo Nation were one of the most severely impacted populations¹. The Navajo Nation is a region spanning Arizona, New Mexico, and Utah that is composed of North American indigenous people known as the Diné. Purpose: To explore the risk factors contributing to the increased rates of COVID-19 infection and severity of infection among the Diné people. Methods: This literature review research process utilized PubMed and JAMA to find scholarly articles on this topic. Search terms …

Molecular Mechanisms Of Sensory Post-Acute Sequelae Of Covid-19 Infection: A Comprehensive Literature Review, Maha Siddiqui

Honors Scholar Theses

The COVID-19 pandemic has upended the world in the last few years, bringing with it countless varying physiological effects, some of which extend beyond the acute phase of the infection. Long-term COVID-19, also referred to as "chronic" or “long-haul” COVID, has become an increasingly prevalent health issue in recent years. Long term sensory loss, particularly anosmia and ageusia (loss of smell and taste respectively), are among the biggest concerns to patients suffering from this condition due to the considerable detriment to their quality of life. This literature review aims to provide an overview of the molecular mechanisms associated with sensory …

Assessing Covid-19 Deaths By Occupation And Race: Louisiana 2020-2021, Anna Reilly, Brittany Babin, Rashanda Littles, Susanne Straif-Bourgeois

Journal of the Louisiana Public Health Association

Background: The COVID-19 pandemic underscored significant health disparities, with social determinants such as living conditions and occupation amplifying the risk for severe outcomes in Black residents. This study examines the intersection of occupation, race, and COVID-19 mortality among Louisiana workers in 2020 and 2021, emphasizing the importance of integrating work-related information into public health surveillance. Methods: Occupation and race were collected from the death certificates of Louisiana resident workforce participants aged 18-70 years with COVID-19 listed as a cause of death for 2020 and 2021. COVID-19 mortality rates per 100,000 workers were calculated and compared using rate ratios for occupational …

The Evolution Of School Leadership In Times Of Crisis, Christopher Butcher, Todd Mccardle

Journal of Excellence in College Teaching and Learning

This case study seeks to address how COVID-19 has affected principals. We approach this study through the lens of Open Systems Theory (Katz & Kahn, 1978), as we attempt to understand how school leaders understand and act during a global pandemic. This research answers the following question: How has the role of a school principal changed since the onset of COVID-19? The data reveal two emerging themes: 1) principals taking on unique caretaker roles and 2) principals increasing their focus on a managerial approach to leadership. The findings support the evolution (and devolution) of leadership approaches that school principals go …

Navigating School Restructuring In The Post-Covid Era: A Principal’S Perspective In Sustaining Organizational Health While Bridging The Academic Achievement Gap, Alma Alicia Perez-Campos

Theses and Dissertations

In 2019, the COVID-19 pandemic led to nationwide school closures, followed by a mandate for schools to reopen in 2020, posing challenges for ensuring both educational continuity and student safety. This paper presents findings from a mixed-method study involving ten campus principals in District A, South Texas, post-pandemic. Qualitatively, the study explored the principals' perspectives on restructuring their campuses to address achievement gaps while maintaining organizational health. Quantitatively, it examined the relationship between achievement and organizational health scores and any differences in organizational health pre- and post-COVID-19. The study aimed to offer insights for future …

Factors Associated With The Ability Of Us Nursing Homes To Accept Residents With Severe Obesity, Cynthia Mcmahan, Bianca Shieu, Alison Trinkoff, Nicholas Castle, David G Wolf, Steven Handler, John A Harris

Faculty, Staff and Student Publications

Objectives: Severe obesity in nursing home (NH) residents is associated with specialized care needs, limited mobility, and challenges in daily living. The COVID-19 pandemic strained NH resources and exacerbated staffing shortages. This study aimed to assess the ability of US NHs to accept and care for residents with severe obesity post-COVID, as well as associated NH factors.

Design: Cross-sectional nationwide survey of NH administrators (2021-2022).

Setting and participants: 290 NHs from a national sample (n = 224) and a targeted sample in Massachusetts and New Jersey (n = 66).

Methods: A survey designed to assess how NHs approach admitting and …

Vitamin D Regulates Covid-19 Associated Severity By Suppressing The Nlrp3 Inflammasome Pathway, Bariaa Khalil, Narjes Saheb Sharif-Askari, Shirin Hafezi, Fatemeh Saheb Sharif-Askari, Fatme Al Anouti, Qutayba Hamid, Rabih Halwani

All Works

Background The role of vitamin D3 (VitD3) in modulating innate and adaptive immunity has been reported in different disease contexts. Since the start of the coronavirus disease-2019 (COVID-19) pandemic, the role of VitD3 has been highlighted in many correlational and observational studies. However, the exact mechanisms of action are not well identified. One of the mechanisms via which VitD3 modulates innate immunity is by regulating the NLRP3-inflammasome pathway, being a main underlying cause of SARS-CoV-2-induced hyperinflammation. Aims and main methods Blood specimens of severe COVID-19 patients with or without VitD3 treatment were collected during their stay in the intensive care …

Ischemic Colitis In A Middle-Aged Man With Covid-19: Case Report And Review Of Literature, Lara Appiah, Subhasis Misra, Stephen Jones

HCA Healthcare Journal of Medicine

Introduction

Coronavirus disease 2019 (COVID-19) was a pandemic that began in 2019 and continues to have morbid and deadly consequences throughout the world. During the beginning of the pandemic, many considered older adults and immunocompromised younger adults to be the only populations at risk for the severe consequences of COVID-19. Throughout the pandemic, this was proven wrong with several case reports and studies showing that relatively younger adults can also suffer serious consequences from this perplexing virus.

Case Presentation

We report a rare case of ischemic colitis in a 42-year-old obese man who presented to the emergency department with quintessential …

Predictors Of Student Reenrollment And Graduation During The Covid-19 Pandemic: Student Characteristics And Circumstances, David Wutchiett, A. W. Logue

Publications and Research

The COVID-19 pandemic decreased college enrollment and disrupted academic progress, particularly among disadvantaged students and institutions. Just before the start of the pandemic in spring 2020, 31,511 undergraduate students attending colleges of The City University of New York responded to a survey detailing their circumstances. Lasso regression followed by mixed-effects logistic regression modeling were used to identify predictors of (1) fall 2020 reenrollment, (2) associate’s-degree graduation or transfer to a bachelor’s-degree program by associate’s-degree students by fall 2022, and (3) graduation with a bachelor’s-degree by bachelor’s-degree students by fall 2022. Part-time status, food insecurity, gender, and major predicted reenrollment and …

Returning To School After A Pandemic And The Lived Experiences Of Rural High School Mathematics Teachers On Student Success, Joshua Saúl Silva

Dissertations

Purpose: The purpose of this qualitative phenomenological methodology investigation was to examine and describe rural mathematics teachers’ lived experiences on the effects of the COVID-19 global pandemic on freshman students returning to school after being online for 2 years through the lens of Bandura’s theory of self-efficacy and serves as part of a thematic dissertation with each researcher focusing on different educators in the K-12 school system.

Methodology: Through qualitative methodology utilizing one-on-one interviews of nine rural high school freshman mathematics teachers with 5 or more years of experience before, during, and after the COVID-19 global pandemic, data was analyzed …

The Healing Power Of Dietary Supplements To Prevent Long-Term Covid-19; A Prospective Observation Study, Hadi Mohammad, Tariq Sadeq, Media Ismail, Swar O Ahmed, Zana Ameen

Polytechnic Journal

The novel coronavirus which emerged from Wuhan, China, in December 2019, was first described as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and affects different systems in the body resulting in different symptoms and severity. The role of macro and micro nutrients plus gut microbiome (gut-lung axis) to boost the immune system is well documented. Therefore, this study aims to boost the immune system particularly the lung immunity to shorten the infection course and prevent post-covid complications. The study strategy depends on maintaining the maximum nutritional status for well-functioning immune system, directing immune system to focus on viral infection by …

Investigating Experiences During Times Of Uncertainty: A Phenomenological Study Of High School Educators, Selinna Creasy

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand the motivation to educate during times of uncertainty for high school educators at an urban Virginian public high school. This study examined the influence of different factors on job satisfaction relating to recognition, growth, relationships, and remuneration. The theory of motivation-hygiene served as the guiding principle, emphasizing the importance of internal and external factors in enhancing job satisfaction. In terms of methodology, a phenomenological transcendental approach was employed. The sample consisted of high school educators teaching students in urban Virginian schools in Grades 9 through 12. The study included 14 participants …

What Weight Changes Really Happened During Covid-19 Among Older Adults?, John A Batsis, Dennis T Villareal

Faculty, Staff and Students Publications

No abstract provided.