Forecasting Covid-19 Cases, Hospital Admissions, And Deaths Based On Wastewater Sars-Cov-2 Surveillance Using Gaussian Copula Time Series Marginal Regression Model, Hueiwang Anna Jeng, Norou Diawara, Cynthia Jackson, Rekha Singh, Kyle Curtis, Raul Gonzalez, David Jurgens, Sasanka Adikari

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Modeling efforts are needed to predict trends in COVID-19 cases and related health outcomes, aiding in the development of management strategies and adaptation measures. This study was conducted to assess whether the SARS-CoV-2 viral load in wastewater could serve as a predictor for forecasting COVID-19 cases, hospitalizations, and deaths using copula-based time series modeling. SARS-CoV-2 RNA load in wastewater in Chesapeake, VA, was measured using the RT-qPCR method. A Gaussian copula time series (CTS) marginal regression model, incorporating an autoregressive moving average model and Gaussian copula function, was used as a forecasting model. Wastewater SARS-CoV-2 viral loads were correlated with …

Resilience Practices In Health Science And Medical Libraries During The Early Stages Of The Covid-19 Pandemic, Justin F. Gaynor

Faculty Research, Scholarly, and Creative Activity

This paper uses the concept of resilience engineering as an organizing principle to discuss best practices that evolved within health science/medical libraries in the United States during COVID-19 crisis, focusing on the period March–August 2020. Protection of library staff, assistance to medical staff, reducing the circulation of misinformation and public health consumerism all required substantial changes to standard processes. These process changes had to arise in the context of both physical isolation and information overload. Some practices became widespread due to their utility, and these are the focus of this report.

Nanobody Screening And Machine Learning Guided Identification Of Cross-Variant Anti-Sars-Cov-2 Neutralizing Heavy-Chain Only Antibodies, Peter R. Mcilroy, Zhuoming Liu, Sean Whelan, Et Al.

2020-Current year OA Pubs

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to persist, demonstrating the risks posed by emerging infectious diseases to national security, public health, and the economy. Development of new vaccines and antibodies for emerging viral threats requires substantial resources and time, and traditional development platforms for vaccines and antibodies are often too slow to combat continuously evolving immunological escape variants, reducing their efficacy over time. Previously, we designed a next-generation synthetic humanized nanobody (Nb) phage display library and demonstrated that this library could be used to rapidly identify highly specific and potent neutralizing heavy chain-only antibodies (HCAbs) with prophylactic and …

Bcg-Induced Dna Methylation Changes Improve Coronavirus Disease 2019 Vaccine Immunity Without Decreasing The Risk For Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Santiago Carrero Longlax, Kent J Koster, Ashish M Kamat, Marisa Lozano, Seth P Lerner, Rebecca Hannigan, Tomoki Nishiguchi, Abhimanyu, Daanish Sheikh, Malik Ladki, Alexandra Portillo, Amrit Koirala, Tajhal D Patel, Zoe Spieler, Aaron B Benjamin, Maxim Lebedev, Theresa U Ofili, Robert W Hutchison, George Udeani, Lynne A Opperman, Gabriel Neal, Anna M Mandalakas, Mihai G Netea, Moshe Arditi, Pablo Avalos, Sandra L Grimm, Cristian Coarfa, Jeffrey D Cirillo, Andrew R Dinardo

Faculty, Staff and Students Publications

BACKGROUND: The BCG vaccine induces trained immunity, an epigenetic-mediated increase in innate immune responsiveness. Therefore, this clinical trial evaluated if BCG-induced trained immunity could decrease coronavirus disease 2019 (COVID-19)-related frequency or severity.

METHODS: A double-blind, placebo-controlled clinical trial of healthcare workers randomized participants to vaccination with BCG TICE or placebo (saline). Enrollment included 529 healthcare workers randomized to receive BCG or placebo. Primary analysis evaluated COVID-19 disease frequency, while secondary analysis evaluated coronavirus immunity in a subset of participants. Study enrollment ceased early in December 2020 following introduction of COVID-19-specific vaccines.

RESULTS: Study enrollment was halted early, prior to reaching …

Heterologous Prime-Pull Mucosal Vaccination With An Adjuvanted Rbd Vaccine Elicits Robust Iga Production And Protects Against Sars-Cov-2, Allyson H Hirsch, Calder R Ellsworth, William A Lewis, Ryan Craig, Amy E Meyer, Jonatan Maldonado, Frania Ramirez Lopez, Syamala Rani Thimmiraju, James B Mclachlan, Xuebin Qin, Nicholas J Maness, Jeroen Pollet, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Lisa A Morici

Faculty, Staff and Students Publications

Despite the efficacy of approved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in preventing severe disease and death, breakthrough infections continue to occur in vaccinated individuals, contributing to further viral mutation and spread. These limitations may be attributable to the poor induction of mucosal immunity by parenteral vaccination. Mucosal adjuvants, such as T-vant, can enhance vaccine-induced immune responses through the generation of antigen-specific antibodies and T cells in the respiratory tract. In this study, we evaluated the protective efficacy of adjuvanted SARS-CoV-2 receptor binding domain (RBD) subunit vaccines administered by homologous and heterologous routes. Immunized mice were challenged with …

Longitudinal Host Transcriptional Responses To Sars-Cov-2 Infection In Adults With Extremely High Viral Load, Vasanthi Avadhanula, Chad J Creighton, Laura Ferlic-Stark, Divya Nagaraj, Yiqun Zhang, Richard Sucgang, Erin G Nicholson, Anubama Rajan, Vipin Kumar Menon, Harshavardhan Doddapaneni, Donna Marie Muzny, Ginger A Metcalf, Sara Joan Javornik Cregeen, Kristi Louise Hoffman, Richard A Gibbs, Joseph F Petrosino, Pedro A Piedra

Faculty, Staff and Students Publications

Current understanding of viral dynamics of SARS-CoV-2 and host responses driving the pathogenic mechanisms in COVID-19 is rapidly evolving. Here, we conducted a longitudinal study to investigate gene expression patterns during acute SARS-CoV-2 illness. Cases included SARS-CoV-2 infected individuals with extremely high viral loads early in their illness, individuals having low SARS-CoV-2 viral loads early in their infection, and individuals testing negative for SARS-CoV-2. We could identify widespread transcriptional host responses to SARS-CoV-2 infection that were initially most strongly manifested in patients with extremely high initial viral loads, then attenuating within the patient over time as viral loads decreased. Genes …

Sex Work And Covid-19: An Intersectional Discussion Of U.S.-Based Sex Worker Experiences During The Pandemic, Sabrina M. Grandia

Cal Poly Humboldt theses and projects

The COVID-19 pandemic impacted all forms of industry, including that of sex work. Between October 2020 until November 2022, I did field research and interviews with nine U.S.-based sex workers throughout those months of the pandemic. Using a grounded theory approach, I asked open-ended questions about their entrance into the industry, business practices, and personal experiences before and during the pandemic. Their stories allow us to gain insight into the impact the pandemic had on them as individuals and their broader communities. My analysis highlights a prominent influence of anti-trafficking policy, politicization of the virus, and the impact of Black …

Double-Blind Randomised Trial Of Saline Solution For Gargling And Nasal Rinsing In Sars-Cov-2 Infection, Sebastian R Espinoza, Lexton Trauffler, Amir Shamshirsaz, Alireza Shamshirsaz, Andres Espinoza, Jimmy Espinoza, Alice O'Brien

Faculty, Staff and Student Publications

Background: Previous studies have shown that hypertonic saline nasal irrigation and gargling reduced the duration of symptoms in upper respiratory infections caused by coronavirus. This study aims to investigate the effects of two saline regimens on symptoms associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Methods: Between 2020 and 2022, individuals aged 18-65 years who tested positive for SARS-CoV-2 infection via polymerase chain reaction (PCR) were randomly assigned to either low- or high-saline regimens for 14 days. The low-saline solutions contained 2.13 g of salt dissolved in eight ounces of warm water, while the high-saline solution contained six grams of …

An Intelligent System Using Deep Learning For Healthcare Monitoring In Light Of The Covid-19 And Future Pandemics Based On Iot, Sara Salman Qasim, Rajaa J. Khanjar, Jamal Nasir Hasoon, Baesher Abdullateff Abad, Ali Hussein Fadil, Shajan.M. Alsowaidi

Al-Esraa University College Journal for Engineering Sciences

Recently, the Internet of Things has become a compelling research field as a new topic of research in various disciplines, particularly in the field of healthcare, because the Internet of Things is rebuilding modern healthcare systems by integrating technology, economics, and social perspectives. The development of healthcare systems from traditional to more personalized systems in which patients can be easily diagnosed, monitored and treated and many people can be helped. People are treated and cared for remotely and this is what some people need in the crisis the world has been through like COVID-19. This epidemic is caused by the …

The Impact Of The Virginia Department Of Education On Music Education During The Covid-19 Pandemic, Erica S. Denham

Masters Theses

This research was to identify how the Virginia Department of Education handled Music Education during the COVID-19 pandemic. When proper support from the Department of Education is given, music educators can run their programs efficiently without doing much research on their own. By examining the COVID-19 policies and procedures created by the Virginia Department of Education, this qualitative study investigated how much emphasis was put on the unique needs of an education in music. Therefore, this investigation examined these policies and procedures to note in what ways music education was taken into special consideration. This study explored three distinct phases …

Dance After Lockdown: Living With Paradox, Simon Ellis, Rowan Mclelland, Rosemary Kostic Cisneros

Kritika Kultura

This writing explores the experiences of people in the UK’s contemporary dance sector during the COVID-19 pandemic.1 It draws on qualitative data from a small research project—Dance after Lockdown—to examine how that sector understands their work, and how the language and ideology of the creative industries have shaped the lives and experiences of contemporary dance artists and institutions in the UK. The paper offers a range of diverse voices as one of the goals of the research was to examine the breadth of experiences, which we hope makes a case for the need to have a dance sector that is …

Covid-19: Kritikal Na Pagsusuri Ng Diskurso Ng Kagawaran Ng Kalusugan Sa Unang Yugto Ng Pandemya Sa Pilipinas, Alona Jumaquio-Ardales, Nathaniel Oco

Kritika Kultura

The paper contributed to the literature of COVID-19 in the Philippines by conducting an interdisciplinary study on the discourse of the Department of Health during the early phase of the pandemic in the country. The frame of Critical Discourse Analysis (CDA), the process of Human Language Technology (HLT), and the concept of Crisis Management (CM) were used in analyzing the press conferences and virtual pressers. There were 56 videos selected from 30 January to 30 May 2020 using the technique of Browsing, Linking, Shortlisting, and Focusing (BLSF). The results of the study showed that: (1) Filipino language was the medium …

Slow And Quick Violence: Illnesses And Injuries In America Is In The Heart, Ling Liu

Kritika Kultura

This article aims to offer a new route into the study of Carlos Bulosan’s America Is in the Heart by going beyond the usual sociocultural focus and turning instead to the material, specifically the illnesses and injuries borne by Filipino bodies—tuberculosis, syphilis, hunger, injuries, even death—to learn about their colonial and migrant experiences. In the novel, tuberculosis affects working-class migrant Filipinos disproportionately in both the Philippines and the United States of America. Migrant Filipinos are also constantly haunted by hunger and are always injured, or even shot; and working-class women frequently die from syphilis. Applying ecocritical theories to study the …

The Burden Mothers Bear: Using The Health Belief Model To Understand How U.S. Mothers’ Intersectional Identities Shape Health Decision-Making During Covid-19, Sydney O'Shay, Kaitlin E. Phillips, Marissa J. Sáez

Publications

The disproportionate impact of COVID-19 on people of color and the burden placed on mothers created a need to better understand how mothers of color made health decisions for their families and communicated these decisions with others during the pandemic. This study investigated how this populations’ intersectional identities played a role in their health decision-making processes and overall experiences during COVID-19. Using the health belief model as a sensitizing concept, we conducted qualitative in-depth interviews with mothers of color across the United States about their lived experiences during the pandemic. Our findings suggest a need for health communicators to address …

Elevated Ambient Temperature Associated With Reduced Infectious Disease Test Positivity Rates: Retrospective Observational Analysis Of Statewide Covid-19 Testing And Weather Across California Counties., Nicholas Wing-Ping Kwok, Joshua Pevnick, Keith Feldman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: From medication usage to the time of day, a number of external factors are known to alter human body temperature (BT), even in the absence of underlying pathology. In select cases, clinical guidance already suggests the consideration of clinical and demographic factors when interpreting BT, such as a decreased threshold for fever as age increases. Recent work has indicated factors impacting BT extend to environmental conditions including ambient temperature. However, the effect sizes of these relationships are often small, and it remains unclear if such relationships result in a meaningful impact on real-world health care practices.

OBJECTIVE: Temperature remains …

Oil, Gold And S&P500 Volatility During The Covid-19 Crisis, Sayali Vichare

Critical Letters in Economics & Finance

The 2020 Global Health Crisis disrupted global financial markets in ways not experienced before, underlining the importance of examining stock market volatility patterns. This paper examines volatility dynamics in gold and oil prices and the S&P 500 Index. The GARCH (1,1) model, well-known in the financial literature, supports the study. The core research findings are summarised as follows: during the pre-COVID-19 period, the S&P 500 exhibited a stable relationship with gold and oil prices. However, there was evidence of shifting dynamics between the S&P 500, gold, and oil volatilities across the studied subsamples: pre-COVID-19, pandemic period, and post-COVID-19. Investors, policymakers, …

National Parks For Future Generations?: The Covid-19 Pandemic’S Impacts On National Parks And Tourism, Colin Cummings '25

Student Research

This paper explores the complex relationship between tourism and the environment in U.S. National Parks, with a focus on the impact of the COVID-19 pandemic. It examines how increased visitation affects wildlife, the spread of invasive species, and the overall health of natural ecosystems. The author argues for a shift in public perception of national parks, emphasizing education, community engagement, and a deeper understanding of the interconnectedness of nature to ensure the preservation of these areas for future generations. The paper also discusses the role of park rangers and historical interpretations of wildlife and the environment, as well as the …

Covid For One: Identifying Obstacles To Self-Management Of Covid-19 For Single Adults, Linda A. Treiber, Christie Emerson, Jenna Shackleford

Faculty Articles

Given the complexities of healthcare provision, it is imperative to understand how single adults experience their interactions with medical professionals and health care organizations, manage care and treatment, and navigate the barriers encountered. This study’s purpose is to understand physical and mental health experiences in consideration of social determinants of health, barriers, and coping strategies for single adults diagnosed with COVID-19. An interpretive phenomenology study design was used with 12 individuals who were single and living alone during the COVID-19 pandemic. Semi-structured, open-ended interviews revealed important aspects of the COVID-19 illness experience. Interviews were transcribed for coding and thematic analysis. …

Reflections From The Pandemic: Is Connectivism The Panacea For Clinicians?, Jennifer Benjamin, Tyson Pillow, Heather Macneill, Ken Masters, Anoop Agrawal, Neil Mehta

Faculty, Staff and Students Publications

The COVID-19 pandemic and the recent increased interest in generative artificial intelligence (GenAI) highlight the need for interprofessional communities' collaboration to find solutions to complex problems. A personal narrative experience of one of the authors compels us to reflect on current approaches to learning and knowledge acquisition and use solutions to the challenges posed by GenAI through social learning contexts using connectivism. We recognize the need for constructivism and experiential learning for knowledge acquisition to establish foundational understanding. We explore how connectivist approaches can enhance traditional constructivist paradigms amid rapidly changing learning environments and online communities. Learning in connectivism includes …

Information Sources And Vaccination In The Covid-19 Pandemic, Nana Osei Asiamah, Paige B. Miller, Xiaoxu Yang, Wesley Shrum

Faculty Publications

Among the issues that remained contentious throughout the pandemic was vaccination: its efficacy, side effects, and the general reluctance of a substantial segment of the population to get vaccinated. The aim of this paper is to understand the role of health information sources in anti-vaccination sentiment and the decision to vaccinate. Regression models were used to analyze data from an online survey of adults in the United States in late 2021 (n = 10,221). The results of the study showed that: (a) information from local and national health experts had a significant positive association with getting the COVID-19 vaccine and …

Mothering, Leadership, And Career: A Narrative Analysis, Joanne Susan Roehm

Dissertations

In March 2020, much of the world was “sent home” from work and periods of lockdown began. In West Michigan, Friday, March 13 was the day that most workplaces closed their doors and employees began working from home for what was assumed to be a period of weeks. In the spring of 2020 between March and April, some million mothers living with school-age children left active work—either shifting into paid or unpaid leave, losing their job, or exiting the labor market all together.

The stories of mothers who experienced the “balancing act” of mothering and working at home during the …

Identity And Inequality Misperceptions, Demographic Determinants And Efficacy Of Corrective Measures, K. Peren Arin, Deni Mazrekaj, Marcel Thum, Juan A. Lacomba, Francisco Lagos

All Works

By conducting two waves of large-scale surveys in the United Kingdom and Germany, we investigate the determinants of identity and inequality misperceptions. We first show that people substantially overestimate the share of immigrants, Muslims, people under the poverty line, and the income share of the richest. Moreover, women, lower-income, and lower-educated respondents generally have higher misperceptions. Only income share misperceptions are associated more with people who place themselves on the left of the political spectrum. In contrast, the other three misperceptions are more prevalent among those who place themselves to the right. We then attempt to correct misperceptions by conducting …

Online Learning Communities And Secondary Educators' Tech-Enhanced Instructional Practices: A Correlational Study, Oscar R. Carrera

Theses and Dissertations

This correlational study investigated how secondary educators' engagement in online learning communities relates to their tech-enhanced instructional practices, a relationship that gained importance following the COVID-19 pandemic's acceleration of educational technology adoption. Through the lens of Keller's ARCS Model of Motivation (Keller, 1987) and demographic analysis, the research examined three key aspects: the relationship between community engagement and tech-enhanced instructional practices, demographic predictors of engagement, and correlations between ARCS motivational components and engagement. Data collected through a cross-sectional survey of 115 secondary educators revealed a statistically significant moderate positive correlation between engagement in online learning communities and tech-enhanced instructional practices. …

An Exploration Of K-3 Teachers’ Beliefs, Attitudes, And Instructional Technology Use Pre-, During, And Post-Covid-19, Patience Mensah-Bonsu Aggrey

Electronic Theses and Dissertations

This qualitative multiple case study explores kindergarten to third-grade teachers use of instructional technology across three different periods: pre-COVID-19, during COVID-19, and post-COVID-19. This research investigates teachers’ attitudes, the use of technological tools by teachers, and the internal (second order) and external (first order) barriers that informed their use of instructional technology before and during the COVID-19 pandemic and continue to influence their use in the post-pandemic phase. Data were collected through questionnaires, interviews, and checklists from eight kindergarten third-grade teachers using a qualitative multiple case study approach. The findings suggest that there was a shift in teachers’ instructional technology …

Early Childhood Educators’ Perceptions Of Changes In Student Executive Function Skills And Challenging Behaviors Post-Covid-19, Sofia Cicero

Honors College Theses

The COVID-19 pandemic greatly impacted children’s lives in a number of ways, including their educational and social lives. Many children had to switch to online learning platforms or follow social distancing rules. There is a lack of research exploring the lasting impact that the isolation period left on young children, specifically those in early childhood (3-7 years old). The purpose of this study was to explore if teachers perceived changes in student executive function skills and challenging behaviors after the pandemic. In addition, play-based learning has been shown to improve executive function and behavioral outcomes, and this study also attempted …

Navigating Physical Activity Promotion And Policy In The Post-Covid-19-Pandemic Era, Justin Richards, Katja Siefken, Michael Pratt, Adrian Bauman, Juliana Mejía-Grueso, Catherine B Woods, Wanda Wendel-Vos, Erica Hinckson, Deborah Salvo, Pedro C Hallal, Andrea Ramírez Varela

Faculty, Staff and Student Publications

Background: There is limited evidence on the priorities and opportunities associated with promoting population physical activity (PA) participation for the post-COVID-19-pandemic future.

Purpose: This study assessed government-led PA promotion efforts before and during the COVID-19 pandemic, along with post-COVID-19-pandemic priorities and recommendations.

Methods: Two separate cross-sectional surveys conducted in 2023. Survey 1 was targeted at the Global Observatory for Physical Activity (GoPA!) Country Contacts. Survey 2 also included key international informants representing influential stakeholders in PA policy implementation.

Results: There were 68 respondents to Survey 1, collectively representing 61 countries. An additional 37 people, including representatives from 14 key international …

The Effectiveness Of Online Learning Technologies In Zimbabwean Primary And Secondary Schools During The Covid-19 Pandemic (2020-2022), Kudakwashe Magwenzi

Electronic Theses, Projects, and Dissertations

ABSTRACT

Zimbabwe, a country with modest technological infrastructure and insufficient government support systems, was forced to switch to online instructions almost overnight as the COVID-19 pandemic raged on. This research investigates the effectiveness of learning technologies applied in Zimbabwean primary and secondary schools during the pandemic based on responses gathered from surveys and in-depth interviews with various stakeholders. This research was informed by the essences of constructivism and connectivism theories that say that optimal learning takes place through engagement, collaboration, and interaction and educational technologies potentially can foster effective learning by facilitating access to information, enabling peer interactions and utilization …

The Impact Of Mindfulness On Student Engagement: During And After The Covid-19 Global Pandemic, Michelle Mendiola

Electronic Theses, Projects, and Dissertations

This qualitative study explored the lived experiences of educational leaders who incorporated mindfulness practices (MFP) student engagement (SE) in their classrooms during and after the COVID-19 global pandemic, utilizing hermeneutic phenomenology and bracketing as research methodologies. The study aimed to understand how these leaders' use of mindfulness impacted student engagement in both online and in-person learning environments. Drawing on semi-structured qualitative interviews, the research examined how mindfulness practices were adapted in response to the unique challenges posed by remote education during the pandemic and how these adaptations have persisted or evolved in post-pandemic teaching. Key findings reveal that mindfulness not …

The Effects Of Covid-19 Lockdowns On Cybersecurity, Natalie Sanders

Electronic Theses, Projects, and Dissertations

The COVID-19 pandemic and subsequent lockdowns forced many Americans to quickly adapt to working from home, many of which had never done so in the past. In addition, organizations were forced to modify security policies and protocols to allow for remote access to sensitive information. The rapid change in security policies as well as the sudden growth of remote access during the pandemic presented a broader landscape for cyber criminals to attack. In this report, we review the number and type of cyberattacks reported from two (2) years before the pandemic through two (2) years after (1998 through 2023), to …

African American Males In Rural Elementary Schools During The Pandemic: Experiences, Challenges, And Strategies For Success, Jessica Lewis

All Dissertations

The present study experimentally examined the impact of the COVID-19 pandemic on elementary African American males living in rural areas. The qualitative study used a phenomenological approach to examine students' perspectives, as understood by the parents and educators (N=10). Using semi-structured interviews and thematic coding, the researcher suggested strategies for successfully closing instructional gaps and meeting the needs of this population moving forward.

The theoretical frameworks that triggered this exploration were Intersectionality, Maslow’s Hierarchy of Needs, and Conflict Theory. The researcher used the theories as a lens to answer the following research questions: (1) How much has COVID-19 revealed the …