Digital Commons Network^™

The Lived Experience Of Therapists During The Covid-19 Pandemic: A Qualitative Study Using Photovoice Methodology, Alison De La Montaigne, Catana Brown, Sarah A. Anderson, Tamara Turner

The Open Journal of Occupational Therapy

Background: The purpose of this study was to explore the experience of therapists during the COVID-19 pandemic.

Method: A qualitative phenomenological design using photovoice methodology for collecting data was used (Wang & Burris, 1997). The study participants included twelve therapists. Using photovoice methodology, the participants used a picture to represent their experience and wrote an accompanying narrative to address the question, “How has COVID-19 impacted your life?” Thematic analysis was used to code and develop themes for the participant photovoices and the virtual focus group transcripts (Braun & Clark, 2006). Zoom was used as the virtual platform for the virtual …

Lessons For Public Policy From The Covid-19 Pandemic, Olga Shvetsova

Political Science Faculty Scholarship

In the early 2020s, as the COVID-19 pandemic unfolded, governments, bureaucracies, and health practitioners around the globe faced unforeseen tasks and responsibilities. The novelty and intensity of the crisis spurred innovation and experimentation in public policy, health policy, and crisis management. However, the pandemic also revealed bottlenecks and adverse incentives within policy framework and healthcare systems. From this experience, critical lessons emerged: the paramount importance of swift and well-informed policy responses and the ability to optimize ongoing policy response as the crisis unfolds.

Dissecting The Binding Affinity Of Anti-Sars-Cov-2 Compounds To Human Transmembrane Protease, Serine 2: A Computational Study, Yue-Hui Shi, Jian-Xin Shen, Yan Tao, Yuan-Ling Xia, Zhi-Bi Zhang, Yun-Xin Fu, Ke-Qin Zhang, Shu-Qun Liu

Faculty, Staff and Student Publications

The human transmembrane protease, serine 2 (TMPRSS2), essential for SARS-CoV-2 entry, is a key antiviral target. Here, we computationally profiled the TMPRSS2-binding affinities of 15 antiviral compounds. Molecular dynamics (MD) simulations for the docked complexes revealed that three compounds exited the substrate-binding cavity (SBC), suggesting noncompetitive inhibition. Of the remaining compounds, five charged ones exhibited reduced binding stability due to competing electrostatic interactions and increased solvent exposure, while seven neutral compounds showed stronger binding affinity driven by van der Waals (vdW) interactions compensating for unfavorable electrostatic effects (including electrostatic interactions and desolvation penalties). Positive and negative hotspot residues were identified …

Lessons Learned From The Covid-19 Pandemic Crisis Management In The Gaza Strip: A Qualitative Study., Belal Aljamal

Journal of the Arab American University مجلة الجامعة العربية الامريكية للبحوث

Aims of the study: The main aim of this study was to discover the lessons learned from the COVID-19 pandemic crisis management from health policymakers' perspective in the Gaza Strip. Methods: The researcher used a qualitative design, targeting 25health policymakers using a purposeful sampling technique and face-to-face semi-structured interviews to collect data. To analyze the interview data, the directed qualitative content analysis approach was used.

Results: All interviewees agreed that the Palestinian Ministry of Health (MoH) managed the COVID-19pandemic well despite the insufficient resources and lack of experience. More specifically, the average of most participants’ assessments of Palestinian MoH “Preparedness” …

“Incline Your Ear To My Cry” (Psalm 88): Walter Brueggemann’S Theology Of Lament In/And The (Post)Pandemic World, Maverick Angelo M. Pelayo

Landas

The COVID-19 pandemic has drastically disrupted the usual course of doing things by which the world and individuals are accustomed, and it continues to do so as many individuals and, five years on, sectors are still reeling from the multi- faceted effects of the pandemic. It is on this account that this contribution seeks to offer the role and relevance of lament when people and communities face various forms of crises. This contribution explores how the practice of lament according to Walter Brueggemann’s theology can be understood, applied, and appropriated in difficult times like this as exemplified in Psalm 88, …

A Single-Cell Compendium Of Human Cerebrospinal Fluid Identifies Disease-Associated Immune Cell Populations, Claudia Cantoni, Roman A. Smirnov, Maria Firulyova, Prabhakar S. Andhey, Tara R. Bradstreet, Ekaterina Esaulova, Marina Terekhova, Elizabeth A. Schwarzkopf, Nada M. Abdalla, Maksim Kleverov, Anne H. Cross, Maxim N. Artyomov, Brian T. Edelson, Gregory F. Wu, Et Al.

2020-Current year OA Pubs

Single-cell transcriptomics applied to cerebrospinal fluid (CSF) for elucidating the pathophysiology of neurologic diseases has produced only a preliminary characterization of CSF immune cells. CSF derives from and borders central nervous system (CNS) tissue, allowing for comprehensive accounting of cell types along with their relative abundance and immunologic profiles relevant to CNS diseases. Using integration techniques applied to publicly available datasets in combination with our own studies, we generated a compendium with 139 subjects encompassing 135 CSF and 58 blood samples. Healthy subjects and individuals across a wide range of diseases, such as multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, …

“That’S Where I Learned To Be A Good Mommy” Understanding How Adults Learn In A Home Visitation, Community-Based Partnership, Kelli R. Kerbawy

Theses, Dissertations and Capstones

In higher education, a growing interest exists in fostering partnerships between institutions and community-based programs to enhance the lives of individuals. These initiatives have encompassed a variety of programs, including life skills development and civic engagement opportunities facilitated by academic experts. Despite the plethora of educational prospects surrounding health, community engagement, and civic improvement, assessing the efficacy of adult learning in community settings remains challenging. Previous research has indicated inadequacies of conventional prenatal education programs in addressing the complex needs of expecting mothers.

This study centered on the adult learning experiences in the Maternal Infant Health Outreach Worker (MIHOW) program, …

Neurosurgical Praxis Guidelines During The Covid-19 Outbreak. Consensus-Based On Currently Available Literature., José Antonio Soriano Sánchez, Bárbara Nettel Rueda, José Alberto Israel Romero Rangel, Armando Alpizar Aguirre, Miguel Ángel Andrade-Ramos, Ulises García Dr., Diego Mendez Rosito, Jorge A. Santos, Sara Patricia Pérez Reyes, Julian Eduardo Soto Abraham, Jose E. Valerio Pascua, Marco Antonio Barajas Romero, Eduardo Díaz Juárez, Alma Griselda Ramírez Reyes, Maria Elena Gonzalez, Claudia Katiutska González Valdez, Félix Domínguez Cortinas, Noé Santiago Ramírez, Tenoch Herrada Pineda, Manuel Eduardo Soto García, Edgar Nathal Vera, Gustavo Melo Guzmán

Archives of Neurosurgery

INTRODUCTION: The World Health Organization recommended several strategies to contain the COVID-19 pandemic, including optimization of care for all patients, especially the seriously ill. Given the strain, the pandemic has posed on healthcare systems around the world, many neurosurgical associations have provided triage recommendations for patients to save resources for the pandemic. We aimed to provide practical recommendations based on specific illnesses requiring surgical procedures commonly performed by neurosurgeons on a life-threatening basis of patient illness. We consider this guideline will help neurosurgeons for the appropriate triage of patients on a daily-situation basis during this pandemic.

METHODS: The Mexican Society …

Social Comparison And Pressure: Examining The Roles Of Sex And Rank, Ashley East

Masters Theses & Specialist Projects

Faculty in academia face intense competition and growing expectations, often shaped by perceptions of others’ performance. During the COVID-19 pandemic, these dynamics were magnified, making social comparison a critical factor in understanding academic workplace pressures. The purpose of this study is to examine the changing work pressures and social comparison tendencies among academics during the COVID-19 pandemic. It is hypothesized that social comparison tendencies will be positively related to time pressure (H1a) and telepressure (H1b), with moderation by sex (H2a and H2b) and organizational rank (H3a and H3b). Using a panel survey of 197 tenure-track and tenured faculty members in …

Covid-19 In The History Of Capitalism, Victor Wallis

Faculty Works

The obvious role of capital in generating poverty, war, and environmental breakdown has not led to a parallel recognition of how deeply it shapes the ideology and practice of healthcare. Progressives view access to healthcare as a matter of “right,” but with rare exceptions they do not focus attention on the wider determinants of health policy – from the life-conditions that shape public health to the prevalence, in capitalist countries, of market-inspired remedies. Looking at the US experience and noting how capitalist priorities have permeated official policies toward Covid-19, this essay discusses how medical objections to these policies have been …

Covid-19 And Capitalism: The Shunning Of Evidence In Sam Friedman’S “House Organ”, Victor Wallis

Faculty Works

Sam Friedman’s September 2025 “House Organ” is devoted to criticizing my writings on COVID-19. Friedman begins by attributing to me a more definitive position than I have actually taken in regard to COVID origins. He then denies that there was censorship around the injection agenda and contends that the negative effects of the jabs were minimal. I present counter-evidence to all these assertions, along with a critique of his argumentation.

Description Of Implementing A Mail-Based Overdose Education And Naloxone Distribution Program In Community Supervision Settings During Covid-19, Carrie B. Oser, Margaret Louise Mcgladrey, Douglas Oyler, Hannah K. Knudsen, Sharon L. Walsh, Susannah Stitzer, Michael Goetz, Marisa Booty, Erica Hargis, Sarah Johnson, Michele Staton, Patricia R. Freeman

Behavioral Science Faculty Publications

Introduction: This study uses the Exploration, Preparation, Implementation , and Sustainment (EPIS) model to retrospectively describe the mail-based overdose education and naloxone distribution (OEND) program developed in collaboration with the Kentucky Department of Corrections (DOC) for use in the HEALing Communities Study in Kentucky (HCS-KY) and details the reach of this innovative delivery model.

Methods: HCS-KY is a community-engaged cluster-randomized trial assessing the effects of implementing evidence-based practices, including OEND, on overdose death reduction across 16 communities highly impacted by the opioid epidemic in Kentucky. ⁶ The study launch coincided with the COVID-19 pandemic. All coalitions in the 16 HCS-KY …

Addressing Barriers To Racial Health Disparity Policy Change Advocacy: Exploring White Defensiveness Strategies, Mary Beth Deline, Mary Katreeb, Emily Mj Mason, Laura N. Richard, Ertemisa Godinez, Kajsa E. Darlymple

Faculty Publications - Communications

Efforts to effect racial health disparity (RHD) policy change are urgent, necessary, and subject to a key barrier: defensiveness among White privileged audiences. Within the literature to date, such defensiveness is under-investigated, and when examined, is typically conceived of as an individual cognitive outcome—a message effect—rather than a communication interaction. Yet policy change advocacy efforts, ranging from community organizing to change campaigns, necessitate communication interactions between advocates and privileged policy change audiences, such as neighborhood groups or policymakers themselves. This defensiveness conceptualization, focused on individual cognitions, therefore limits our understanding of interactive communication barriers in RHD policy advocacy processes. To …

11. Me-Search Research: The Use Of A Self-Study Methodological Approach To Teaching Documentation, Cynthia Korpan

Documenting Teaching Excellence

As teaching in higher education becomes increasingly complex (De Courcy, 2015), documenting one’s teaching practice requires instructors1 to take a more nuanced approach. The diversity associated with teaching today, impacted by COVID (Scholkmann et al., 2024), the various teaching modalities now available (McManus et al., 2024), and the introduction of artificial intelligence into academia (Li, 2025; Sok & Heng, 2024), has created a concoction of elements available to each instructor. This means that every instructor, bringing their own philosophical and ontological approach to teaching, has a myriad of decisions to make about how to best teach each course to students. …

Being And Becoming Third-Space Professionals: A Case Study From Low-And-Middle Income Countries, Azra Naseem, Jannat Karim Khan, Tashmin Khamis, Jane Rarieya

Institute for Educational Development, East Africa

This case study explores the authors’ experiences of establishing the identity of third-space professionals at a multi-country university with campuses on three continents. In particular, it draws on their identities and experiences as female leaders in educational development. Using autoethnography, the authors reflect on their experiences to identify issues, strategies, and areas for further development regarding third-space professionals’ identities, particularly with regard to women. As the concept of third-space professionals is relatively new in Low- and Middle-Income Countries (LMICs) where the university is located, this journey of becoming and being third-space professionals was fraught with challenges that question traditional norms …

Design And Implementation Of An Evidence-Based Pilot Program To Support New Graduate Nurses' Transition To Professional Practice: Application Of Soft Skills Education In An Associate Degree Program, Torri Crosby-Martin

All Capstone Projects

Problem Statement:
Post-pandemic nurse graduates experienced difficulty transition to professional practice due to limited focus on soft skills acquisition in pre-licensure nursing curricula.

Background:
Faculty characterized graduates as underprepared for professional practice, stating concerns affecting retention, patient outcomes, and work satisfaction.

Aim:
The quality improvement project goal was to address the transition to practice readiness by providing soft skills education to associate degree students.

Theoretical Framework:
This project applied Benner's Novice-to-Expert MOdel and Duchscher's Stages of Transition.

Methods:
Utilizing a mixed methods approach, March-April 2024, a sample size of 28 participants completed both pre- and post-Casey-Fink Readiness for Practice Surveys …

The Effect Of Inclusive Leadership By Pastoral Leaders On Catholic Parish Vitality, Matthew F. Manion

Dissertations

Catholic parish life in the United States has passed the point of decline where minor changes will enable it to grow again. Church leaders need a new missionary culture and outward-focused approaches to reach people today with the timeless truths of the faith. The old mindset of putting all the responsibility on the shoulders of the clergy to solve problems no longer works. Since heterogeneous groups make better decisions than homogeneous groups in complex, adaptive situations, this study explores the hypothesis that inclusive leadership by Catholic parish leaders leads to more innovation and better solutions to the challenges of church …

Masculinism, Institutional Violence And #Metoo: Understanding Australian University Responses To The Covid-19 Pandemic, Emily Gray, Jacqueline Ullman, Mindy Blaise, Jo Pollitt

Research outputs 2022 to 2026

This article offers an analysis of data from the project Sexism, Higher Education, and Covid-19: The Australian Perspective. The authors argue that the gendered impact of the pandemic in Higher Education Institutions constitutes a form of institutionally perpetrated sexist harassment, and that raising awareness of the ways in which institutions themselves enable and perpetrate such harassment is consistent with the aims of the #MeToo movement. This article is intended to act as testament to the ways in which Australian universities function as masculinist institutions that, during this time of crisis, deployed tactics that were experienced by women and minority-identifying research …

The Autonomy Paradox, Working From Home And Psychosocial Hazards, Alexis Vassiley, Azadeh Shafaei, Mehran Nejati, Leigh Ann Onnis, Tim Bentley

Research outputs 2022 to 2026

This article investigates the experience of knowledge workers in New South Wales (NSW), Australia, who worked from home during the COVID-19 pandemic to understand their exposure to psychosocial hazards, specifically: workload and work pace; the work-home interface and social isolation. We explored how the increased autonomy afforded by working from home fitted with workers’ actual experience during the pandemic. Drawing on interviews with 33 NSW remote workers and 19 line-managers conducted in early 2021, this article argues that the increased autonomy afforded to employees by remote work is paradoxical. Many interviewees worked longer hours and experienced work intensification, as well …

Identification Of Host-Pathogen Protein Interactions: Yeast Two-Hybrid Analysis Of Sars-Cov-2 Nsp10 And Human Cellular Proteins, Antonios Argyriou

Selected Full-Text Master Theses 2021-

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has resulted in over 774 million cases and 7 million deaths worldwide, establishing it as one of the most devastating pandemics in recorded history. While current therapeutic approaches primarily target viral entry mechanisms and specific enzymes, the limited understanding of non-structural protein functions hinders the development of comprehensive antiviral strategies. This research focuses on Nsp10 (non-structural protein 10), a highly conserved 139-amino acid protein essential for viral mRNA capping and replication. Nsp10 serves as a critical cofactor in the formation of methyltransferase complexes with Nsp14 and Nsp16, playing a vital role in viral …

Association Between Lifetime Interpersonal Violence And Post– Covid-19 Condition Among Women In Kentucky, 2020-2022, Ayşe Güler, Heather M. Bush, Katie Schill, Nurlan Kussainov, Ann L. Coker

Biostatistics Faculty Publications

Objective: The COVID-19 pandemic increased the risk of interpersonal violence. We investigated the association between lifetime interpersonal violence experience and risk of post–COVID-19 condition (the persistence of symptoms of COVID-19 and severity of health problems associated with COVID-19 that last a few weeks, months, or years) among women with lifetime interpersonal violence experience.   Methods: Women participants aged ≥18 years in Kentucky’s Wellness, Health & You—COVID-19 study completed online quantitative surveys about the impacts of the pandemic, developing COVID-19, and symptoms of post–COVID-19 condition. We conducted cross-sectional analyses estimating rate ratios of developing COVID-19 and symptoms of post–COVID-19 condition during the …

Exploring The Link Between Covid-19 And Transverse Myelitis: A Case Report, Sara Sanghera, Trivianne Franklin, Veeranna Vibhuti, Danielle Ford

North Texas Research Forum 2025

Transverse myelitis (TM) is a rare inflammatory syndrome of the spinal cord that is often attributed to immune-mediated responses which lead to demyelination and the resultant varying degrees of motor, sensory, and autonomic dysfunction. While COVID-19 virus itself is known to present with anosmia, ageusia and Guillian Barre syndrome, a few rare cases of COVID-virus related TM have been reported. This case presents a 61-year-old female experiencing bilateral lower extremity weakness with brisk to absent reflexes. Onset of the symptoms was of 3 days origin, and she was tested positive for COVID-19. Patient did not have upper extremity symptoms but …

An Evaluation Of The Decline In Primary Care Physician Visits, 2010 To 2021, Anuradha Jetty, Marie Ezran, Alison Huffstetler, Yalda Jabbarpour

Department of Family & Community Medicine Faculty Papers

INTRODUCTION: Primary care is the backbone of the United States healthcare system, yet it continues to be underfunded and inaccessible to many. Previous studies explored primary care visit patterns until 2016, leaving gaps in our understanding of how recent factors like state Medicaid expansions, the Coronavirus Disease 2019 (COVID-19) pandemic, and population growth have influenced these patterns. Hence, the objective of the current study was to analyze the trends in primary care visits provided by outpatient clinicians over time and by visit type and contextualize study findings within the changing healthcare landscape.

METHODS: The Medical Expenditure Panel Survey data (2010-2021) …

Resilience And Resourcefulness: How Crisis Centers In Louisiana Adapted Services During Covid-19, Fanny Ramirez, Ashlyn Barclay, Rockia Harris

Faculty Publications

Purpose: This article examines how crisis centers in Louisiana, USA, adapted their direct care services during COVID-19 to continue helping survivors affected by violence. Organizational resilience theory serves as the project’s main theoretical framework. As such, we report on how community- and university-based crisis centers drew on principles of resilience and resourcefulness to adapt their direct care services (e.g., crafting normalcy, putting alternative logics to work) during this difficult time. Method: We draw on 21 in-depth interviews with upper-level administrators from organizations working in violence against women conducted during the summer of 2020. The interview transcripts yielded 184 single-spaced pages …

Creating & Validating A Teacher Resilience Scale In The U.S. Context, Joy Mccreary

CGU Theses & Dissertations

The teaching force faces significant challenges, including high attrition rates and an aging workforce, exacerbated by the COVID-19 pandemic. Prior research highlights teacher resilience as a critical factor in addressing these challenges, emphasizing its multi-dimensional and contextual nature. While several international scales have been developed to measure teacher resilience, none exist tailored to the unique educational landscape of the United States. This study developed and validated a U.S.-specific Teacher Resilience Scale (USMTRS), confirming its strong reliability and multidimensional structure. Findings showed that teacher resilience is widespread and most strongly tied to job satisfaction, while only weakly related to burnout. Results …

Assessing The Impact Of Medicaid Expansion On The Labor Market, Healthcare Access, And Health Outcomes During The Covid-19 Pandemic, Kaavya Narayan

CMC Senior Theses

This thesis examines the impact of Medicaid expansion status on labor market outcomes, healthcare access, and health outcomes during COVID-19. Using data from the CDC’s Behavioral Risk Factor Surveillance System and a Difference-in-Differences (DiD) model, I estimate the effects of Medicaid expansion on unemployment, financial barriers to care, obesity, and poor health before and after the pandemic. The analysis also accounts for state-level political and demographic characteristics, gender, marital status, and education level. My results show that non-expansion states, relative to expansion states of similar political and demographic breakdowns, are significantly more disadvantaged in terms of obesity, poor health, financial …

Effect Of Paxlovid On Neurodevelopmental Disorder Diagnosis Outcomes In Offspring Of Mothers Infected With Sars-Cov-2 During Pregnancy, Simone Rogers

CMC Senior Theses

The onset of the 2020 COVID-19 pandemic brought concern over the effects that this virus would have on pregnancy and fetal outcomes, specifically neurodevelopmental outcomes. Maternal immune activation (MIA), caused by infection during pregnancy, is known to result in neurodevelopmental disorder (NDD) diagnosis in offspring, typically autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). This effect has already been observed in mothers who were infected with COVID-19 during pregnancy. However, in 2023, Paxlovid, the COVID-19 antiviral drug, became available to patients experiencing symptoms of the virus, including pregnant women. Consequently, this study seeks to determine whether the risk of …

The Impact Of Job Loss On Health-Related Outcomes During The Covid-19 Pandemic, Kelly Prawira

CMC Senior Theses

In this paper, I explore the effects of job loss during the COVID-19 pandemic on self-reported general and mental health conditions and health insurance coverage. Using Medical Expenditure Panel Survey data from 2018-2022, I evaluate the effects of job loss on these health-related outcomes by conducting a year-over-year analysis. I also examine changes in job loss effects during the pandemic by performing a difference-in-differences analysis. Overall, I find that job loss is associated with a higher likelihood of having fair or poor general and mental health, a higher likelihood to have Medicaid/SCHIP, and a lower likelihood to have private insurance. …

Baseline Predictors For 28-Day Covid-19 Severity And Mortality Among Hospitalized Patients: Results From The Impacc Study, Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M Becker, Alison D Augustine, Al Ozonoff, Leying Guan, Steven H Kleinstein, Bjoern Peters, Elaine Reed, Matt Altman, Charles R Langelier, Holden Maecker, Seunghee Kim, Ruth R Montgomery, Florian Krammer, Michael Wilson, Walter Eckalbar, Steven E Bosinger, Ofer Levy, Hanno Steen, Lindsey B Rosen, Lindsey R Baden, Esther Melamed, Lauren I R Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Joanna Schaenman, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S Calfee, David J Erle, Impacc Network, Lucy F Robinson, Charles B Cairns, Elias K Haddad, Mary Ann Comunale

Faculty, Staff and Students Publications

Introduction: The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demographic, blood cytometry, serum receptor-binding domain (RBD) antibody titers, metabolomics, targeted proteomics, nasal metagenomics, Olink, nasal viral load, autoantibody, SARS-CoV-2 antibody titers, and nasal and peripheral blood mononuclear cell (PBMC) transcriptomics data from patients hospitalized with COVID-19. The aim of this study is to select baseline biomarkers and build predictive models for 28-day in-hospital COVID-19 severity and mortality with most predictive variables while prioritizing routinely collected variables.

Methods: We analyzed 1102 …

No Evidence Of Mmr Induced Trained Immunity To Prevent Sars Cov2: Results From A Multi-Centre Rct, Sinead Delany-Moretlwe, George Kyei, Erik Dubberke, Linda Yun, Leon Du Toit, Mary Politi, Ben Swan, Anne Deschryver, Sherry Mckinnon, Ananya Gupta, Shabaana Khader, Michael S Avidan, Et Al.

2020-Current year OA Pubs

BACKGROUND: Measles-containing vaccines (MCV), by training innate immune cells, are hypothesized to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19).

METHODS: In this international, double-blind, placebo-controlled trial, we randomly assigned adults, 18 years and older, to receive MCV or saline. The primary outcome was polymerase chain reaction (PCR) confirmed symptomatic COVID-19, up to 60 days after intervention. Secondary outcomes were PCR-confirmed symptomatic COVID-19 and serologically confirmed SARS-CoV-2 infection, up to 150 days after intervention.

RESULTS: Of 3411 randomised participants, the modified intention-to-treat population included 1607 in the MCV and 1545 in the saline group. …