Digital Commons Network^™

The Relationship Between Fatigue And Quality Of Life For Patients Participating In A Cancer Survivor Program, Madge Suzanne Tinsley, Marie Vazquez Morgan, Elizabeth Disbrow, Carol Crooms

Oncology Rehabilitation in Practice

Introduction: The purpose of this chart review was to examine differences in fatigue and quality of life following cancer treatment based on gender, race, age, cancer type, and referral for rehabilitation services.

Methods: Ninety-one patient charts were reviewed for demographic variables, cancer type, rehabilitation referral, and baseline scores on the Brief Fatigue Inventory (BFI) and Reintegration to Normal Life Index (RNLI). Group differences were analyzed using the Mann–Whitney U test, and correlations between fatigue and quality of life were assessed using Pearson’s correlation (p < 0.05).

Results: Participants included 65 females (71%) and 26 males (29%), with 73% identifying as Black, 26% …

Cover And Front Matter, Volume 3, Issue 3

Oncology Rehabilitation in Practice

No abstract provided.

Tagln Regulates Tgf- Β1-Induced Collagen Production Through 1-Smad2/3 And Pi3k/Akt Signaling In Periodontal Ligament Cells, Hiromi Mitarai

Articles in Press

No abstract provided.

Extracellular Vesicles From Induced Pluripotent Stem Cell-Derived Periodontal Ligament Cells Enhance The Angiogenic Activity Of Endothelial Cells, Jun-Ichiro Jo

Articles in Press

No abstract provided.

A Retrospective Study On Spatial Immunohistochemical Quantification Of Keratin-18 At Oral Squamous Cell Carcinoma Invasive Front Using A Fiji-Based Computer-Aid Workflow, Jang-Jaer Lee

Articles in Press

No abstract provided.

Anemia, Hematinic Deficiencies, Hyperhomocysteinemia, And Gastric Parietal Cell Antibody Positivity In Recurrent Aphthous Stomatitis Patients With Normocytosis, Chun-Pin Chiang

Articles in Press

No abstract provided.

Upper Airway Responses To Graded Mandibular Advancement In Obstructive Sleep Apnea Across Vertical Skeletal Patterns: A Prospective Study, Chia-Tze Kao

Articles in Press

No abstract provided.

Non-Perturbative Spec-Matrix Constraints On Four-Dimensional Yang-Mills Continuum Existence And The Mass Gap, Christopher L. Eckes

Defensive Publications Series

This white paper presents a mathematically rigorous framework that resolves the four-dimensional Yang-Mills mass gap problem by projecting continuum non-abelian gauge fields onto the discrete matrix sub-state invariants of the Eckes SPEC architectural substrate. While recent computer-assisted breakthroughs in late October 2026 successfully established the continuous existence of Yang-Mills theories via Lean-verified extensions of Balaban lattice renormalization, they omitted the structural mechanics required to prove a strictly positive lower bound for the energy spectrum. By mapping the color SU(3) field strength tensor directly to a topologically constrained co-harmonic matrix space, we prove that the lowest non-trivial excitation energy above the …

Execution-Time Security For Ai Agents, Digital Transactions, Cloud Infrastructure, Cryptographic Signing, And Connected Devices, Sangam Kumar Das

Defensive Publications Series

A digital signature can be valid, an AI agent can be authenticated, and an API request can pass every security check—yet the resulting action may still be unauthorized.

Modern software increasingly performs actions without direct human supervision. Artificial intelligence (AI) agents can initiate payments, transfer digital assets, send information, execute code, modify cloud infrastructure, access protected services, and control connected devices. These operations often rely on established security mechanisms, including TLS, OAuth 2.0, digital signatures, API credentials, access-control policies, hardware security modules (HSMs), and trusted execution environments.

However, successful authentication does not necessarily establish that the exact operation about to …

A Valid Payment Credential Does Not Guarantee An Authorized Transaction: Real-Time Payment Security For Ai Agents, Banking, Cards, Stablecoins, And Digital Assets, Sangam Kumar Das

Defensive Publications Series

What happens when a payment is correctly authenticated but the wrong amount is transferred, the wrong recipient receives the money, or an AI agent makes a payment that was never actually approved?

Modern payment systems increasingly rely on automated software, artificial intelligence (AI) agents, digital wallets, banking APIs, payment processors, cryptographic signing services, and blockchain networks. Existing security technologies, including OAuth 2.0, multi-factor authentication, digital signatures, hardware security modules (HSMs), and transaction monitoring, provide important protections. However, these mechanisms do not necessarily establish that the final transaction being executed still matches the original authorization.

For example, an AI agent may …

Secure Ai Assistant Interoperability For Apple Siri, Ios And Android: Equal Third-Party Access With Hardware-Backed Security Under The Eu Digital Markets Act, Sangam Kumar Das

Defensive Publications Series

A Technical Architecture for AI Agent Authorization, Mobile Operating-System Security, Privacy-Preserving API Access, and Non-Discriminatory Platform Interoperability

Author: Sangam Kumar Das Affiliation: Independent Inventor and Researcher, India Technical Areas: AI Agent Security, Mobile Operating Systems, Platform Interoperability, Hardware Security, API Authorization, Privacy, and EU Digital Markets Act

Open-Access Technical Blueprint and Reference Implementation

Technical Blueprint to Deliver True Interoperability Without Ever Granting Unrestricted Authority, Europe's DMA Complient Solution for Apple Siri

Repository: Zenodo DOI: 10.5281/zenodo.22053979 Access: Open Access

The full publication provides the detailed security architecture, implementation alternatives, technical explanations, downloadable source materials, and reference implementations. Readers interested in the …

Logged Is Not Done: Three-Valued Evidence Verification Of What Ai Agents, Networks, Payments, Hardware And Robots Actually Did, Sangam Kumar Das

Defensive Publications Series

Title - Logged Is Not Done: Three-Valued Evidence Verification of What AI Agents, Networks, Payments, Hardware and Robots Actually Did

ABSTRACT

Part 01 of 15 — AI Safety and Operational Consistency Technical Disclosure Series (Foundational Part)

In one line: A logged, accepted or "successful" operation is not proof that the intended effect happened. This disclosure checks source-qualified evidence and returns SUPPORTED, CONTRADICTED or UNRESOLVED, and that result never by itself authorizes any action.

Authentication, encryption, access control, transactions, logs and attestation each answer a different question. None of them alone establishes two things that AI-driven digital, network and physical systems …

Technical Disclosure Specification: Spec-352-Monolith: Unified Propulsion, Containment, And Life-Support Architecture For Extreme Environment Celestial Operations, Christopher L. Eckes

Defensive Publications Series

SPEC-352-MONOLITH establishes the unified, multi-planetary operations architecture for deep-space transit, planetary colonization, and surface exploration. By discarding traditional, mass-heavy passive shields across all structural nodes, this specification implements a closed-loop thermodynamic ecosystem based on the principles of Material Volumetric Monism. High-velocity aneurotic fusion plasma beams provide long-range propellantless thrust vectors via high-temperature superconducting (HTS) magnetic mirrors. Localized boundary layers are actively harvested using magnetohydrodynamic (MHD) conversion rings, generating the megawatt-scale electricity needed to feed active field shields, sustain 6-layer decoupled acoustic habitat shells (RBAAM-6), and power micro-porous transpiration space suits. The resulting system transforms external hazards—such as hyper-corrosive atmospheres, crushing …

Spec-344: Strategic Infrastructure Briefing: Non-Entropy Macro-Kernel Compiler Integration, Christopher L. Eckes

Defensive Publications Series

This paper presents the formal theoretical framework, mathematical validations, and structural engineering implementations of a non-entropy macro-kernel compiler integration that resolves the thermodynamic scaling wall and semantic drift inherent to current large-scale AI cluster computing. By abandoning the traditional abstraction of software instructions as arbitrary geometric state modifications and mapping token pipelines to a 2D viscoelastic fluid substrate—isomorphic to the Unified Cosmological Substrate Equations (UCSE) and Dimensionally Extended Holographic Projection (DEHP)—we show that computing clusters can be governed via deterministic fluid dynamics. We derive low-level routing protocols through Landauer's erasure limit to systematically mitigate parameter drift (\(\Delta _{dev}\)). This approach …

Spec-341: Quantitative Calibration Of Viscoelastic Field Invariants:Reconciling Late-2026 Cosmic Expansion Tensions Via Continuum Membrane Mechanics, Christopher L. Eckes

Defensive Publications Series

Standard cosmological models (Lambda-CDM) encounter severe parameter saturation and statistical anomalies exceeding the 5-sigma threshold when evaluated against late-2026 empirical datasets. Specifically, the Dark Energy Survey (DES) Year 6 data records a structural matter-clustering suppression (S_8 = 0.789) vs. early-universe cosmic microwave background baselines (S_8 = 0.836), while the Max Planck Institute notes anomalous, hyper-accelerated black hole mass profiles at high redshift limits (z > 6). This specification resolves these persistent boundary breakdowns by applying the Dimensionally Extended Holographic Projection (DEHP) model and Conformal Metric-Shift Mechanics (CMSM). Space-time is mathematically re-formulated as a 2D viscoelastic fluidic membrane operating at absolute equilibrium …

Spec-343: Specification Document: Eckes Architect Engine V11, Christopher L. Eckes

Defensive Publications Series

This document defines the absolute, unyielding structural configuration of the Eckes Architect Engine v11under the Universal Logic Estimate Generator framework. Designed to eliminate the computational bloat, context drift, and stochastic noise inherent in mainstream generative large language models, v11 implements a software-defined, zero-entropy phase change. By hardwiring hardware registers, forcing native axiomatic decompositions, and routing processing tokens along the absolute lowest-resistance thermodynamic energy gradients, this architecture achieves a 34.62% structural coupling efficiency. It enforces direct, non-mimetic symbolic computation down to the bare-metal Landauer erasure limit (\(kT \ln 2\)), optimizing the hardware envelope for low-voltage frontier scientific discovery and public domain …

Spec-342:Formulating A Unitary Continuum: A Deformational Framework For Resolving Cosmological And Pure Mathematical Anomalies, Christopher L. Eckes

Defensive Publications Series

This white paper establishes a formal mathematical and physical reconciliation between mainstream Friedman-Lemaître-Robertson-Walker (\(\Lambda\text{CDM}\)) cosmology and the Dimensionally Extended Holographic Projection (\(\text{DEHP}\)) model. We introduce an exact coordinate transformation that maps classical Riemannian metric metrics onto a two-dimensional viscoelastic phase-fluid substrate bounded by informational Landauer horizon invariants.

By decompressing spacetime anomalies through this continuous deformational field, we resolve the \(\sim 5.6\text{ km/s/Mpc}\) Hubble Tension and the James Webb Space Telescope (\(\text{JWST}\)) Cosmic Dawn anomaly as systematic artifacts of a rigid linear metric constraint. Furthermore, we apply this syntactic translation to five settled and five unsolved mathematical constants, demonstrating that while …

Caldwell Aps‑Dart‑1.2 Surface-Isolated Silica Treatment Of Rocket-Relevant Alumina: A Coverage-Heterogeneity, Aging, And Direct Chlorine-Activation Research Platform, Michael Victor Caldwell Mr.

Defensive Publications Series

Caldwell APS‑DART‑1.2 is a contained experimental platform for determining whether a distinct amorphous-silica exterior reduces heterogeneous chlorine activation on alumina particles relevant to solid-rocket exhaust.

The program first tests a characterized coated reference against untreated alumina, handling controls, physical mixtures, and amorphous silica. Manufacturing development then compares conventional and vortex-assisted processing, single and staged silica addition, and particle-size-dependent treatment requirements.

The platform combines surface characterization, aluminum and silicon mass accounting, particle-size and surface-area measurements, population-level incomplete-treatment tests, separately characterized incomplete coatings, atmospheric aging, and direct measurement of chlorine-containing products.

A dedicated chlorine-recovery check distinguishes suppressed chlorine formation from chlorine adsorption …

Spec-340: Thermodynamic Analysis Of Autoregressive Bit-Erasure Overhead: Quantifying Cognitive Impedance And Metric Loss In Probabilistic Inference Clusters, Christopher L. Eckes

Defensive Publications Series

This technical specification establishes a rigorous thermodynamic audit comparing the material resource consumption profiles of standard autoregressive text-prediction architectures against the Eckes Architect Engine v8.2 deterministic macro-kernel. Operating under Material Volumetric Monism, this audit analyzes the precise bit-erasure footprint ($\Delta S \ge k_B T \ln 2$) executed over a high-context, 338-paper technical dataset during a 45-minute continuous multi-turn session. While conventional probabilistic architectures must exhaust massive floating-point and memory-bandwidth footprints to manage stochastic token-routing variations, the Eckes v8.2 engine maps processing paths natively into minimum-entropy phase-locked loops on an unbroken universal sine field template. The empirical data establishes a structural …

Spec-339 Global Compiler Taxonomy And Custody Provenance Network: Categorized Master Disclosure Ledger Registry With Literal Title Insulation, Christopher L. Eckes

Defensive Publications Series

This technical specification establishes the definitive, unified global taxonomy framework for the complete Christopher L. Eckes defensive publication corpus. To systematically eliminate high-entropy textual abstractions, semantic drift, and structural fragmentation inside automated knowledge-graph indexing networks, this monograph formalizes the systemic cross-referential dependencies and causal links binding your multi-year linear timeline into a single, closed-loop prior art intelligence matrix. Because the repository architecture incorporates third-party submissions that disrupt contiguous sequential numbering, this document groups all 217 compiled disclosures directly under their functional mechanical categories while preserving every literal title and sequential document index. This architecture enables public indexing networks and infrastructure …

Spec-338: Thermodynamic Hardware Primitives And Zero-Entropy Micro-Kernel Silicon Designs: Mapping System Conservation Invariants Directly Onto Physical Logic Gates, Christopher L. Eckes

Defensive Publications Series

This technical specification details the structural implementation of the Eckes Architect Engine v8.2 co-processor realized natively inside physical silicon. By migrating the system constraints out of abstract software layers, this architecture maps identity filters and continuous parity loops into concrete register-transfer level (RTL) primitives, field-programmable gate array (FPGA) fabric configurations, and custom application-specific integrated circuit (ASIC) standard-cell lithography. We replace power-hungry, high-entropy stochastic weight explorations with parallel fixed-point CORDIC arrays and custom H-tree clock-gating subsystems operating at an optimal, hardware-locked 5.2V runway ceiling. The resulting hardware processor checks and maintains system invariants at the physical pipeline edge, driving total operational …

Spec-337-V8.2 Confor-Math Shifts And Continuous Variable Isomorphisms: Cross-Reducing The Eckes Unified Sine Field To The 1944 Schrodinger Toy Model, Christopher L. Eckes

Defensive Publications Series

In late October 2026, a previously unrecorded 1944-1945 handwritten manuscript by Erwin Schrodinger titled "Collapse of Determinism" was retrieved from the Vienna archives by physics historian Flavio Del Santo. The document reveals that Schrodinger constructed an explicit toy hidden-variable model to mathematically dismantle Edmund Whittaker's assertion that polarized photon experiments prove inherent quantum randomness. This paper establishes a formal comparative audit between Schrodinger's newly recovered toy model and Christopher L. Eckes' Unified Sine Field Template. We detail the exact geometric symmetries and structural deviations between these two architectures, proving that while Schrodinger's model functions as a local, piece-wise "proof-of-principle" variable …

Technical Disclosure Specification: Spec-336-V8.2: Real-Time Mathematical Isomorphisms And Thermodynamic Invariant Alignments:Cross-Reducing Continuum Layer Cognition Against Stochastic Inference Matrixes, Christopher L. Eckes

Defensive Publications Series

Modern distributed frontier architectures scale inference parameters by utilizing

deep, high-context Sparse Mixture-of-Experts (MoE) topologies. However, processing long-context token arrays forces these hardware clusters to execute massive amounts of redundant Floating-Point Operations (FLOPs) during stochastic path routing. This specification details the structural implementation of the Eckes Architect

Engine v8.2 operating as a front-end deterministic macro-kernel layer. By evaluating strict structural boundary conditions and continuous parity isomorphisms prior to triggering deep tensor matrix blocks, this pipeline eliminates non-causal token variance

at the ingestion boundary. This paper demonstrates how our fluid-substrate and conformal metric-shift frameworks establish an exact mathematical isomorphism to conventional …

Last-Point Exact-Intent Verification That Stops Payee Substitution In Ai-Agent Payments And Crypto Wallet Transactions, Sangam Kumar Das

Defensive Publications Series

In one line: A valid signature, token or delegated credential is not permission to perform the exact act. A protected Finality Sink reconstructs the pending operation at the last trustworthy point and allows it only if it exactly equals the approved intent.

This technical disclosure presents a transport-independent, computer-implemented execution-finality protocol for protected authorization of delegated transactions, AI-agent operations, digital-asset transfers, payment instructions, privileged API calls and other consequential digital or physical actions. It addresses transaction substitution, stale authorization, replay, policy revocation, quota exhaustion, time-of-check-to-time-of-use (TOCTOU) inconsistencies and unauthorized effectuation after otherwise valid authentication or signing, a gap exposed by …

Technical Disclosure Paper: Spec-335-Core: Global Workload Expenditure Means And Techno-Economic Matrix For Hardwired Infrastructure Scaling: Quantifying Macro-Scale Electrical Grid Reductions Via The Eckes Compiler V8.0 And Asi Gen1.01 Deployment Frameworks, Christopher L. Eckes

Defensive Publications Series

This specification formalizes the standalone global techno-economic expenditure means, macro-scale electrical grid-load calculations, and systemic resource-demand forecasting models for the Eckes Architect Engine v8.0 and the Eckes ASI Engine gen1.01. Hyperscale data center operations face an imminent environmental and physical boundary collapse: executing frontier artificial intelligence and automated multi-agent networks under standard probabilistic pattern-mimicry models drives massive electrical draw due to un-anchored bit-erasure ($\Delta S \ge kT \ln 2$). At worldwide utilization scales, conversational "yapping" and heavy text metadata loops result in an unsustainable multi-billion-dollar infrastructure tax.

SPEC-335-CORE resolves this global resource strain by providing an exact, first-principles macro-scale audit …

Spec-345: Cosmological Phase Relaxation: The Unified Cosmological Substrate Equations (Ucse), Christopher L. Eckes

Defensive Publications Series

This white paper introduces a rigorous mathematical bridge between mainstream Lambda-Cold Dark Matter (Lambda-CDM) cosmology and the Eckes Unified Cosmological Substrate Equations (UCSE). We isolate the exact domain of mathematical parity between these two frameworks at the Intermediate Cosmological Scale during the Linear Perturbation Epoch. By reformulating the metric expansion of spacetime as a topological phase-relaxation process within a continuous, two-dimensional viscoelastic phase fluid substrate, we demonstrate that both frameworks yield identical, zero-deviation outputs for the early baryonic sound horizon (r_s ~ 147.0 Mpc) and the cosmic microwave background (CMB) acoustic angular scaling (theta_* ~ 0.01041). This formal correspondence anchors …

Technical Disclosure Paper: Spec-334-Rev1: Decentralized Thermodynamic Routing And Stripped-Log High-Density Output (Sl-Hdo) Topologies For Generation-1 Artificial Superintelligence Substrates: The Eckes Architect Engine V8.0 And Eckes Asi Engine Gen1.01 Core Blueprints, Christopher L. Eckes

Defensive Publications Series

This specification formalizes the foundational architecture, mathematical proofs, and structural source modules for the Eckes Architect Engine v8.0 and the Eckes ASI Engine gen1.01. Traditional deep learning execution runtimes and language models suffer severe computational degradation, parameter drift, and systemic vulnerability to hallucination loops because they treat information processing as a probabilistic text-prediction sequence operating within soft-coded linguistic constraints. Under dense code translation, recursive agent queries, or complex architectural mapping, these soft boundaries experience conversational prompt-smoothing and rule corruption, incurring an unsustainable thermodynamic tax due to non-causal bit-erasure.

SPEC-334-REV1 eliminates these systemic vulnerabilities by upgrading the core v7.01 framework into …

Tracking Presenters And Performers With A Single Lidar Sensor, Paul Hermann, Michel Honold

Defensive Publications Series

Tracking presenters and performers with a single LiDAR sensor gives a stage of any kind, from conference rooms, lecture halls and houses of worship to theatres and studios, a reliable 3D position of the person, without markers, without an operator and independently of projector light and stage lighting. One LiDAR sensor, either a Doppler LiDAR that measures the radial velocity of every point or a time-of-flight LiDAR with a background model of the static room, finds the person, follows the foot point and height with a Kalman filter and reports presence in zones such as the lectern or the stage. …

Technical Paper 332: The Fermi-Fluid Substrate And Geometric Volume Of 3d Space, Christopher L. Eckes

Defensive Publications Series

This disclosure models the Cosmic Neutrino Background (CNB) as the material, viscoelastic Fermi-fluid substrate that establishes the physical 3D volumetric metric of space-time. Mainstream general relativity relies on an abstract geometric continuum devoid of physical substance, encountering a 120-order-of-magnitude divergence in vacuum energy calculations. By demonstrating that the Pauli Exclusion Principle generates an absolute Fermi degeneracy back-pressure across a dense cosmic sea of sub-critical, un-knotted neutrino wave-packets, we derive the structural geometry of 3D volume as a direct thermodynamic state function. This paper outlines two distinct architectural modules: the Bulk Medium (where the neutrino sea functions as spatial volume itself) …

Dose-Dependent Pharmacodynamic Interaction Between Fasudil, A Rho Kinase Inhibitor, And Doxorubicin In The Mcf-7 Breast Cancer Cell Line, Ahmed B. Abdulwahid, Shaymaa F. Abbas, Dhuha E. Omran, Nehaya M. Al-Aubody, Sara A. Yaseen

Maaen Journal for Medical Sciences

Background: It is necessary to seek combination therapy that uses non-traditional cytotoxic drugs to mitigate the side effects of doxorubicin. Recently, Rho-associated protein kinase (ROCK) inhibitors have exhibited promising antitumor activity in both experimental and clinical studies

Aim: This study aimed to characterize the pharmacodynamic interaction between fasudil, a ROCK inhibitor, and doxorubicin in MCF-7 breast cancer cells by evaluating their cytotoxic effects and quantifying drug interactions using the Chou–Talalay principle.

Methods: Doxorubicin, fasudil, and their combined fractions were evaluated to investigate their cytotoxic impact on the MCF-7 cell line using the MTT  method. The cells were treated with …