Digital Commons Network^™

Global Impact Of Covid-19 On Stroke Care, Raul G. Nogueira, Mohamad Abdalkader, Muhammad M. Qureshi, Michael Frankel, Ossama Y. Mansour, Hiroshi Yamagami, Zhongming Qiu, Mehdi Farhoudi, James E. Siegler, Ameer E. Hassan

School of Medicine Publications

Background

Aims

Methods

Results

Implications Of Helminth Immunomodulation On Covid-19 Co-Infections, Nathalie Chacon, Leonor Chacin-Bonilla, Italo M. Cesar

School of Medicine Publications

Coronavirus disease 2019 (COVID-19) and helminths infections can be in a synergistic epidemic in developing and suburban areas of industrialized countries. The coinfected hosts will derive a parasite-specific Th2 innate and adaptive immune response with CD4+ T cells, eosinophils, interleukin-4, interleukin-5, and interleukin-10. In the early stages of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, virus-specific Th1 cytotoxic CD8+ T cell, interleukin-6, interferon-γ, and interleukin-27 by lung are keys in controlling viral replication in the lung epithelial cells and limiting the pathology to other organs, like the intestine. CD4+ and CD8+ T cells are associated with protective immunity …

Clinical Characteristics And Laboratory Biomarkers For Patients With Suspected Covid-19 Infection Within Hca Healthcare, Scott Gutovitz, Justin Hanson, Christian Vandever, Dietrich Jehle

HCA Healthcare Journal of Medicine

Background

The coronavirus infection (COVID-19), also known as the Severe Acute Respiratory Syndrome Virus 2 (SARS-CoV-2), caused significant illness and a worldwide pandemic beginning in 2020. Early case reports showed common patient characteristics, clinical variables and laboratory values in these patients. We compared a large population of American COVID-19 patients to see if they had similar findings to these smaller reports. In addition, we examined our population to identify any differences between mild or severe COVID-19 infections.

Methods

We retrospectively accessed a de-identified, multi-hospital database managed by HCA Healthcare to identify all adult emergency department (ED) patients that were tested …

Metal Oxide Sensor Array Test Bed Prototype For Diagnostic Breath Analysis, Tiffany C. Miller

USF Tampa Graduate Theses and Dissertations

Detection of specific target biomarkers is a critical step for electronic nose technologies in breath analysis. Electronic nose technologies have been successfully demonstrated in the air quality, meat processing, and the citrus industries, as well as cancer clinical trials. The novel design, assembly, and implementation of a test bed prototype of an electronic nose system is introduced in this Dissertation. To verify the feasibility of a test bed prototype design, a Corona Virus Disease 2019 (COVID-19) breath simulation mixture of alcohol, acetone, and carbon monoxide was presented to the test bed prototype in the laboratory. The COVID-19 breath simulation mixture …

Palm Oil Price–Exchange Rate Nexus In Indonesia And Malaysia, Afees A. Salisu, Abdulsalam Abidemi Sikiru

Bulletin of Monetary Economics and Banking

In this study, we extend the literature analyzing the predictive content of commodity prices for exchange rates by examining the role of palm oil price. Our analysis focuses on Indonesia and Malaysia, the two top producers and exporters of palm oil, and utilizes daily data covering the period from December 12, 2011 to March 29, 2021, which is partitioned into two sub-samples based on the COVID-19 pandemic. Relying on a methodology that accommodates some salient features of the variables of interest, we find that on average the in-sample predictability of palm oil price for exchange rate movements is stronger for …

Bagaimana Media Memberitakan Pandemi: Analisis Isi Berita Mengenai Covid-19 Di Detik.Com Dan Kompas.Com, Ghina Aribah, Dien Anshari

Perilaku dan Promosi Kesehatan: Indonesian Journal of Health Promotion and Behavior

Introduction. During the pandemic COVID-19, online news is one of the most accessible channels to disseminate information about the current situation and prevent and mitigate the disease. Objective to get the portrayals of risk communication in news articles about the COVID-19 pandemic Methods. Used content analysis method with descriptive quantitative approach. Data came from selecting news articles published by detik.com and kompas.com in March and April 2020 using a stratified proportional random sampling technique. Results. There were limited news articles that provide epidemiology information, disease characteristics, how to mitigate the disease, the non-health effects of COVID-19, and criticism of the …

Hubungan Antara Pengetahuan Dan Sikap Dengan Perilaku Pencegahan Covid-19 Pada Peserta Seminar Online Stikes Raflesia 7 April 2020, Susilawati Gunawan, Iis Sinsin, Andri Yan Prima Zani

Perilaku dan Promosi Kesehatan: Indonesian Journal of Health Promotion and Behavior

Introduction. Early in 2020, the world was shocked by the COVID-19 pandemic. The increasing number of cases was fast and spread to various countries. The rapid spread and the number of cases increasing have resulted in the importance of socialization and education on preventing and controlling this infectious disease. The community must play a role in breaking the chain of COVID-19 transmission by implementing health protocols. Objective. to find out the knowledge, attitudes and practices of the community to prevent the spread of the COVID-19 Methods. used a quantitative approach with a cross-sectional design by distributing questionnaires online using the …

Comparison Of Clinical Characteristics And Outcomes Between Covid-19 Pneumonia And H1n1 Influenza, Nosheen Nasir, Iffat Khanum, Kiren Habib, Rimsha Ahmed, Mujahid Hussain, Zahra Hasan, Muhammad Irfan

Department of Medicine

Introduction: The COVID-19 pandemic has been likened to the 2009 H1N1 influenza pandemic. We aim to study the similarities and differences between patients hospitalized with COVID-19 and H1N1 influenza in order to provide better care to patients, particularly during the co-circulation of Influenza A Subtype H1N1 and SARS-CoV-2.
Material and methods: A retrospective cohort study was conducted in order to compare clinical characteristics, complications, and outcomes of hospitalized patients with PCR-confirmed H1N1 influenza pneumonia and COVID-19 at a tertiary care center in Karachi, Pakistan.
Results: A total of 115 patients hospitalized with COVID-19 were compared with 55 patients with H1N1 …

Clinical Teaching And Learning In The Covid-19 Era And Beyond: The Emergent And Emerging Scenarios, Shashikala K. Bhat, Veena Manja, Vinutha Shankar, Shashikiran Umakanth

Manipal Journal of Medical Sciences

The need for social distancing due to the COVID-19 pandemic has compromised traditional medical education. Educators and students in low-resource settings face diverse challenges in clinical teaching, learning, and assessment. The pandemic has necessitated a rapid transition from traditional pedagogical strategies to virtual platforms. Challenges in low resource settings include knowledge and training in technology, limited resource allocation for faculty development in virtual teaching methods, and financial constraints limiting the use of available technologies. There is also a lack of constructive alignment between outcomes, instructional strategies, and assessment of curriculum delivery in virtual platforms as the earlier curriculum design was …

Emerging Advances Of Nanotechnology In Drug And Vaccine Delivery Against Viral Associated Respiratory Infectious Diseases (Varid), Amir Seyfoori, Mahdieh Shokrollahi Barough, Pooneh Mokarram, Mazaher Ahmadi, Parvaneh Mehrbod, Alireza Sheidary, Tayyebeh Madrakian, Mohammad Kiumarsi, Tavia Walsh, Kielan D Mcalinden, Chandra C Ghosh, Pawan Sharma, Amir A Zeki, Saeid Ghavami, Mohsen Akbari

Center for Translational Medicine Faculty Papers

Viral-associated respiratory infectious diseases are one of the most prominent subsets of respiratory failures, known as viral respiratory infections (VRI). VRIs are proceeded by an infection caused by viruses infecting the respiratory system. For the past 100 years, viral associated respiratory epidemics have been the most common cause of infectious disease worldwide. Due to several drawbacks of the current anti-viral treatments, such as drug resistance generation and non-targeting of viral proteins, the development of novel nanotherapeutic or nano-vaccine strategies can be considered essential. Due to their specific physical and biological properties, nanoparticles hold promising opportunities for both anti-viral treatments and …

Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease And Implications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz

Department of Paediatrics and Child Health

Background/aim: Since the outbreak of the COVID-19, numerous therapies to counteract this severe disease have emerged. The benefits of Tocilizumab for severely infected COVID-19 patients and the methodologies of ongoing clinical trials are explored.
Materials and methods: A systematic search adhering to PRISMA guidelines was conducted in PubMed, Cochrane Central, medRxiv, and bioRxiv using the following keywords: “Tocilizumab,” “Actemra,” “COVID-19.” An additional subsearch was conducted on Clinicaltrials.gov to locate ongoing tocilizumab trials.
Results: A total of 13 studies were included in the meta-analysis comprising 2120 patients. The treatment group had lower mortality compared to the control group (OR = 0.42, …

2021-06-26_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Cardiac Transplant Recipient With Covid-19 Induced Acute Hypoxic Respiratory Failure: A Case Report, Ariyon Schreiber, Kalaimani Elango, Kimberly Hong, Chowdhury Ahsan

School of Medicine Faculty Research

Background: Heart transplant recipients represent a particularly vulnerable patient population to the novel coronavirus disease 2019 (COVID-19) due to chronic immunosuppression and high rates of comorbidities. Currently, data are limited and evidence to guide management of heart transplant recipients with COVID-19 is sparse. In this case report, we provide a summary of the current literature as well as an in-depth analysis of our clinical decision-making. Case summary: A 67-year-old female who underwent cardiac transplantation 1 year prior was found to have acute hypoxic respiratory failure due to COVID-19. Her immunosuppressant medications were modulated with discontinuation of mycophenolate and titration of …

Brain Fog: Understanding The Neurocognitive Symptoms Of Covid-19, Kavita Sharma

Aurora GME

•Hospitalized COVID 19 patients commonly have neurologic complications.

•Myalgias, headache, encephalopathy, and dizziness may be most common, occurring in approximately one third of patients in China, Europe, and the United States.

•Dysgeusia or anosmia commonly reported.

•Stroke, movement disorders, motor and sensory deficits, ataxia, and seizures appear uncommon.

•Neurologic complications are higher in critically ill ICU patients

•This talk was to help highlight the pathophysiology of neuro COVID to shed insights on the care of patients with neurological symptoms post COVID

2021-06-25_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Endothelial Senescence And Chronic Fatigue Syndrome, A Covid-19 Based Hypothesis, Adonis Sfera, Carolina Osorio, Carlos M. Zapata Martín Del Campo, Shaniah Pereida, Jose Campo Maldonado, Zisis Kozlakidis

School of Medicine Publications

Myalgic encephalomyelitis/chronic fatigue syndrome is a serious illness of unknown etiology, characterized by debilitating exhaustion, memory impairment, pain and sleep abnormalities. Viral infections are believed to initiate the pathogenesis of this syndrome although the definite proof remains elusive. With the unfolding of COVID-19 pandemic, the interest in this condition has resurfaced as excessive tiredness, a major complaint of patients infected with the SARS-CoV-2 virus, often lingers for a long time, resulting in disability, and poor life quality. In a previous article, we hypothesized that COVID-19-upregulated angiotensin II triggered premature endothelial cell senescence, disrupting the intestinal and blood brain barriers. Here, …

Minority Health Disparities In A 21st-Century Pandemic: A Comprehensive Report Of Project Research Focused On New York, Teresa Harrison, Theresa Pardo, Jordan Carleo-Evangelist, Lynn Warner

Understanding and eliminating minority health disparities in a 21st-century pandemic: A White Paper Collection

The COVID-19 pandemic has exacted a starkly unequal toll on New Yorkers of color – both in terms of the virus itself and the accompanying social and economic impacts of the pandemic. These are not separate issues. They stem from the structural racism embedded in American society. While our work begins by establishing a statistical baseline for how the virus’s unequal toll played out in the early months of the COVID-19 pandemic in New York, any analysis of these disparities that looks solely at hospitalizations and deaths misses a tremendous piece of this tragic and preventable story. Minority health disparities …

2021-06-22_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2021-06-21_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Impacts Of Covid-19 On Rural Medical Business Models, Kendra L. Stefan

Anthós

This paper is concerned with the question of how COVID-19 impacts the medical delivery system in a rural community. It presents findings from interviews of medical professionals participating in an isolated rural community and public health officials that coordinate preparedness planning. This paper reviews barriers of access to healthcare in an already constricted system. Then looks at the implications of COVID-19 as an additional strain. Interviews of professionals will survey preparedness, regulatory impacts, repercussions to the business model, impact on service capacity, and opportunities for improvement. Interested parties would include patient advocates, patients, healthcare workers, politicians, and employers.

Social Distancing In The Context Of Covid-19 Anxiety: A Social Cognitive Approach, Allyson S. Graf, Abigail Nehrkorn-Bailey, Amy Knepple Carney

Journal of Social, Behavioral, and Health Sciences

As the impact of COVID-19 continues, engagement in social distancing is essential. Using Social Cognitive Theory, the current study examined the unique roles of COVID-19 anxiety and self-efficacy on the relationships between information-seeking and risk perception as predictors of social distancing intention. A convenience sample of 960 adults (M = 37.81 years, SD = 11.65) completed an author-designed online survey. Participants completed measures on behavioral intention, information-seeking, risk perception, COVID-19 anxiety, and self-efficacy. Moderated mediations examined the theoretically proposed relationships among the variables. COVID-19 anxiety moderated the relationship between risk perception and self-efficacy, but not the association between information-seeking …

Effect Of Clinical Isolate Or Cleavage Site Mutations In The Sars-Cov-2 Spike Protein On Protein Stability, Cleavage, And Cell-Cell Fusion, Chelsea T. Barrett, Hadley E. Neal, Kearstin Edmonds, Carole L. Moncman, Rachel Thompson, Jean M. Branttie, Kerri Beth Boggs, Cheng-Yu Wu, Daisy W. Leung, Rebecca E. Dutch

Molecular and Cellular Biochemistry Faculty Publications

The trimeric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) is the sole viral protein responsible for both viral binding to a host cell and the membrane fusion event needed for cell entry. In addition to facilitating fusion needed for viral entry, S can also drive cell-cell fusion, a pathogenic effect observed in the lungs of SARS-CoV-2-infected patients. While several studies have investigated S requirements involved in viral particle entry, examination of S stability and factors involved in S cell-cell fusion remain limited. A furin cleavage site at the border between the S1 and S2 subunits (S1/S2) has …

2021-06-20_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2021-06-19_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

A Feverish Spring: A Comparative Analysis Of Covid-19 News Framing In Sweden, The Uk, And Egypt, Hend Abdelgaber Ahmed El-Behary

Theses and Dissertations

Based on framing and the social responsibility theoretical frameworks, this comparative study analyzes the dominance of frames in the media coverage of the COVID-19 global pandemic across three countries that have adopted different preventative measures: Sweden (herd immunity) the United Kingdom (full lockdown) and Egypt (partial lockdown ‘curfew’). While several studies have investigated the media’s role during COVID-19, few have analyzed the frames used by the media. The analyses that were made here, for the most part, is on individual countries. The current study bridges a gap by using a comparative approach to interpret the frames discovered in news articles …

Sars-Cov-2 E Gene Variant Alters Analytical Sensitivity Characteristics Of Viral Detection Using A Commercial Reverse Transcription-Pcr Assay, Stephen Tahan, Bijal A Parikh, Lindsay Droit, Meghan A. Wallace, Carey-Ann D Burnham, David Wang

Open Access Publications

Diagnostic assays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are essential for patient management, infection prevention, and the public health response for coronavirus disease 2019 (COVID-19). The efficacy and reliability of these assays are of paramount importance in both tracking and controlling the spread of the virus. Real-time reverse transcription-PCR (RT-PCR) assays rely on a fixed genetic sequence for primer and probe binding. Mutations can potentially alter the accuracy of these assays and lead to unpredictable analytical performance characteristics and false-negative results. Here, we identify a G-to-U transversion (nucleotide 26372) in the SARS-CoV-2 E gene in three specimens …

The Impact Of Contact Tracing On The Spread Of Covid-19: An Egocentric Agent-Based Model, Andrew Pilny, Lin Xiang, Corey Huber, Will Silberman, Sean Goatley-Soan

Communication Faculty Publications

At its core, contact tracing is a form of egocentric network analysis (ENA). One of the biggest obstacles for ENA is informant accuracy (i.e., amount of true contacts identified), which is even more prominent for interaction-based network ties because they often represent episodic relational events, rather than enduring relational states. This research examines the effect of informant accuracy on the spread of COVID-19 through an egocentric, agent-based model. Overall when the average person transmits COVID-19 to 1.62 other people (i.e., the R₀), they must be, on average, 75% accurate with naming their contacts. In higher transmission contexts (i.e., …

Elite Cues And The Rapid Decline Of Trust In Science Agencies On Covid-19, Lawrence C. Hamilton, Thomas G. Safford

Faculty Publications

The COVID-19 pandemic has been marked by political divisions in US public trust of scientists. Such divisions are well known on other science topics, but regarding COVID-19 they arose suddenly, with disastrous results. Public distrust of scientists has been variously explained in terms of conflicts with belief systems, psychology, peer influences, or communication from elites. Three surveys conducted from March to July 2020 in the US state of New Hampshire observed changing perceptions on COVID-19, providing a test of alternative explanations. Over this period trust in science agencies such as the CDC for information on the coronavirus fell dramatically among …

Plotting The Literature On Precautionary Measures Of Covid-19: A Scientometric Analysis Of Web Of Science, Muhammad Shoaib, Nusrat Ali, Abeel Naseer

Library Philosophy and Practice (e-journal)

This study attempted to evaluate the scholarly publications on COVID-19, social distance, physical distance, social isolation, and self-isolation employing the scientometric analysis technique from 2020 to 2021. The main purpose was to consolidate the published scholarship on the COVID-19 in the Web of Science indexed documents. A total of 635 publications were found. The results indicated that social distance and COVID-19 was the top topic along with the article as a type of document, and the majority were published in the English language in 2021. The name of Gimenez-Llort L was at top of the list of authors, along with …

Comparative Analysis Of Pediatric Covid-19 Infection In Southeast Asia, South Asia, Japan, And China, Judith Ju Ming Wong, Qalab Abbas, Soo Lin Chua, Ririe Fachrina Malisie, Kah Min Pon, Tomohiro Katsuta, Hongxing Dang, Pei Chuen Lee, Muralidharan Jayashree, Quratulain Maha

Department of Paediatrics and Child Health

There is a scarcity of data regarding coronavirus disease 2019 (COVID-19) infection in children from southeast and south Asia. This study aims to identify risk factors for severe COVID-19 disease among children in the region. This is an observational study of children with COVID-19 infection in hospitals contributing data to the Pediatric Acute and Critical Care COVID-19 Registry of Asia. Laboratory-confirmed COVID-19 cases were included in this registry. The primary outcome was severity of COVID-19 infection as defined by the World Health Organization (WHO) (mild, moderate, severe, or critical). Epidemiology, clinical and laboratory features, and outcomes of children with COVID-19 …