Digital Commons Network^™

Losses, Gains, And Changes To The Food Environment In A Rural Kentucky County During The Covid-19 Pandemic, Makenzie L. Barr, Courtney Martin, Courtney T. Luecking, Kathryn M. Cardarelli

Dietetics and Human Nutrition Faculty Publications

The COVID-19 pandemic has caused alterations to be made in the way many people access, prepare, and consume food. Rural communities are particularly impacted due to pre-existing structural vulnerabilities, i.e., poverty, lack of infrastructure, and limited fresh food options. This study aimed to characterize experiences of one rural Appalachian community’s changes to the food environment during the pandemic. In April 2021, six focus groups were conducted with residents of Laurel County, Kentucky. Using grounded theory, we identified losses, gains, and overall changes to the community food environment since the onset of COVID-19. Seventeen Laurel Countians (17 female; ages 30–74) participated …

2021-11-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

A Class Ii Mhc-Targeted Vaccine Elicits Immunity Against Sars-Cov-2 And Its Variants, Novalia Pishesha, Paul W Rothlauf, Mariel J Liebeskind, Maria A Vakaki, Louis-Marie Bloyet, Marjorie Cornejo Pontelli, Ma Xenia G Ilagan, William J Buchser, Sean P J Whelan, Et Al

Open Access Publications

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 100 million infections and millions of deaths. Effective vaccines remain the best hope of curtailing SARS-CoV-2 transmission, morbidity, and mortality. The vaccines in current use require cold storage and sophisticated manufacturing capacity, which complicates their distribution, especially in less developed countries. We report the development of a candidate SARS-CoV-2 vaccine that is purely protein based and directly targets antigen-presenting cells. It consists of the SARS-CoV-2 Spike receptor-binding domain (Spike

A Guide To The 87th Texas Legislative Session, José Menéndez, Pearl D. Cruz

The Scholar: St. Mary's Law Review on Race and Social Justice

Challenges and potential solutions during the 87th Texas Legislative session.

Infant Outcomes Following Maternal Infection With Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2): First Report From The Pregnancy Coronavirus Outcomes Registry (Priority) Study., Valerie J. Flaherman, Yalda Afshar, W. John Boscardin, Roberta L. Keller, Anne H. Mardy, Mary K. Prahl, Carolyn T. Phillips, Ifeyinwa V. Asiodu, Vincenzo Berghella, Brittany D. Chambers, Joia Crear-Perry, Denise J. Jamieson, Vanessa L. Jacoby, Stephanie L. Gaw

Department of Obstetrics and Gynecology Faculty Papers

Infant outcomes after maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well described. In a prospective US registry of 263 infants, maternal SARS-CoV-2 status was not associated with birth weight, difficulty breathing, apnea, or upper or lower respiratory infection through 8 weeks of age.

Statistical Analysis Of Anxiety And Self-Perceived Stress Level Among People During Covid-19 Pandemic, Md. Tanwir Akhtar, Neha Gupta, Saeed H. K. Al-Dulaimi

Journal of Statistics Applications & Probability

In this paper, a survey was conducted online to analyze anxiety and perceived stress level among the people living in Delhi- NCR. A questionnaire was developed on the web, and its link was distributed via the internet to the people of Delhi NCR, which consists of students, professionals, nonprofessional’s, etc. The results confirm that between the two groups, female shows more anxiety level, whereas males have more perceived stress during the COVID-19 outbreak. Alternatively, the level of anxiety is high among the people aged 36-45 years, whereas perceived stress rate was higher among older people.

Statistical Analysis Of Anxiety And Self-Perceived Stress Level Among People During Covid-19 Pandemic, Md. Tanwir Akhtar, Neha Gupta, Saeed H. K. Al-Dulaimi

Journal of Statistics Applications & Probability

In this paper, a survey was conducted online to analyze anxiety and perceived stress level among the people living in Delhi- NCR. A questionnaire was developed on the web, and its link was distributed via the internet to the people of Delhi NCR, which consists of students, professionals, nonprofessional’s, etc. The results confirm that between the two groups, female shows more anxiety level, whereas males have more perceived stress during the COVID-19 outbreak. Alternatively, the level of anxiety is high among the people aged 36-45 years, whereas perceived stress rate was higher among older people.

Shea Pediatric Leadership Council Commentary: Inpatient Visitor Considerations For Pediatric Patients During The Coronavirus Disease 2019 (Covid-19) Pandemic, Allison H. Bartlett, Karen A Ravin, Lorry G Rubin, Caitlin Mcgrath, Annabelle De St Maurice, W Matthew Linam, Latania K. Logan, Martha Muller, Carolyn Caughell, Lynn Ramirez-Avila, Shea Pediatric Leadership Council

Pediatrics Research and Scholarship

No abstract provided.

Mast Cell Activation Symptoms Are Prevalent In Long-Covid, Leonard B Weinstock, Jill B Brook, Arthur S Walters, Ashleigh Goris, Lawrence B Afrin, Gerhard J Molderings

Open Access Publications

OBJECTIVES: Hyper-inflammation caused by COVID-19 may be mediated by mast cell activation (MCA) which has also been hypothesized to cause Long-COVID (LC) symptoms. We determined prevalence/severity of MCA symptoms in LC.

METHODS: Adults in LC-focused Facebook support groups were recruited for online assessment of symptoms before and after COVID-19. Questions included presence and severity of known MCA and LC symptoms and validated assessments of fatigue and quality of life. General population controls and mast cell activation syndrome (MCAS) patients were recruited for comparison if they were ≥18 years of age and never had overt COVID-19 symptoms.

RESULTS: There were 136 …

How Work From Home Has Affected The Occupant’S Well-Being In The Residential Built Environment: An International Survey Amid The Covid-19 Pandemic, Zhihong Pang, Burcin Becerik-Gerber, Simi Hoque, Zheng O’Neill, Giulia Pedrielli, Jin Wen, Teresa Wu

Faculty Publications

This paper presents the results from an international survey that investigated the impacts of the built environment on occupant well-being during the corona virus disease 2019 (COVID-19) pandemic when most professionals were forced to work from home (WFH). The survey was comprised of 81 questions focusing on the respondent’s profiles, residences, home indoor environmental quality, health, and home working experiences. A total of 1460 responses were collected from 35 countries, and 1137 of them were considered complete for the analysis. The results suggest that home spatial layout has a significant impact on occupant well-being during WFH since home-life distractions and …

Responding To The Pandemic: A Multicountry Study On Social-Political Factors And Health Outcomes Of Covid-19, Lan Yao

Theses and Dissertations (ETD)

Introduction. Coronavirus Disease 2019 (COVID-19) poses a major global threat to human beings, which has caused devastating consequences of population health, political, and economic crises in many countries. This dissertation was composed of three research activities to study the following aims: (1) review the existing literature focusing on political factors and health outcomes of COVID-19; (2) assess the relationship between democracy and case fatality rate of COVID-19 by controlling for the effect of age, comorbidity, health expenditure, healthcare workforce, and population density; and (3) identify the trajectory pattern cases peak days, deaths peak days, and peak periods.

Methods. We accessed …

Vaccine Clinical Trials And Data Infrastructure, Ana Santos Rutschman

Utah Law Review

We find ourselves at a momentous turn in the history of vaccines. The COVID-19 pandemic triggered a quasi-global vaccine race that not only compressed vaccine research and development (R&D) timelines, but also paved the way for the administration of a new type of vaccine technology – mRNA vaccines, which work in substantially different ways from the vaccines in use before the pandemic.

While the process of bringing emerging COVID-19 vaccines to market has taken place in an unusually short timeframe, it was largely predicated on the same scientific and regulatory processes that govern the development, approval and deployment of new …

Bisindolylmaleimide Ix: A Novel Anti-Sars-Cov2 Agent Targeting Viral Main Protease 3clpro Demonstrated By Virtual Screening Pipeline And In-Vitro Validation Assays, Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye, Prakasha Kempaiah

Chemistry: Faculty Publications and Other Works

SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential functions within its proteome. Here, we focused on repurposing approved and investigational drugs/compounds. We targeted seven proteins with enzymatic activities known to be essential at different stages of the viral cycle including PLpro, 3CLpro, RdRP, Helicase, ExoN, NendoU, and 2′-O-MT. For virtual screening, energy minimization of a crystal structure of the modeled protein was carried out using the Protein Preparation Wizard (Schrodinger LLC 2020-1). Following active site selection based on data mining and COACH predictions, we performed a high-throughput virtual screen of drugs and investigational molecules (n = …

Positron Emission Tomography In The Covid-19 Pandemic Era, Chentao Jin, Xiaoyun Luo, Shufang Qian, Kai Zhang, Yuanxue Gao, Rui Zhou, Peili Cen, Zhoujiao Xu, Hong Zhang, Mei Tian

Faculty, Staff and Student Publications

Coronavirus disease 2019 (COVID-19) has become a major public health problem worldwide since its outbreak in 2019. Currently, the spread of COVID-19 is far from over, and various complications have roused increasing awareness of the public, calling for novel techniques to aid at diagnosis and treatment. Based on the principle of molecular imaging, positron emission tomography (PET) is expected to offer pathophysiological alternations of COVID-19 in the molecular/cellular perspectives and facilitate the clinical management of patients. A number of PET-related cases and research have been reported on COVID-19 over the past one year. This article reviews the current studies of …

Associations Between Genetic Variants In The Vitamin D Metabolism Pathway And Severity Of Covid-19 Among Uae Residents, Fatme Al-Anouti, Mira Mousa, Spyridon N. Karras, William B. Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K. Tay, Bassam Mahboub, Habiba Alsafar

All Works

Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were …

A Qualitative Phenomenological Study On Moral Distress And The Nursing Student During The Covid-19 Pandemic, Alan Peter Howard

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the phenomenon of moral distress on nursing students who engaged in clinical experiences during the COVID-19 pandemic. This research study was supported by Jean Watson’s theory of human caring (Watson, 2006) as it explained the relationship between a nursing students’ provision of care and the moral dilemma and potential moral distress related to threats to that care. This study was also presented within the conceptual framework of Patricia Benner’s model from novice to expert (Benner, 1984). Within this framework, the nursing student as novice may not have the skills or experience …

Covid-19 And Its Impact(S) On Innovation, Clark Asay, Stephanie Plamondon Bair

Utah Law Review

In previous work, we explored how certain characteristics of adversity are often more conducive to innovation than others. In this Article, prepared as part of the Lee E. Teitelbaum Utah Law Review Symposium—The Law & Ethics of Medical Research, we review some of that work and apply it specifically to the COVID-19 context. We conclude by assessing certain policy implications in light of how the COVID-19 pandemic has both spurred and hindered innovation.

Covid-19 And Tourism: Analyzing The Effects Of Covid-19 Statistics And Media Coverage On Attitudes Toward Tourism, Maksim Godovykh, Jorge Ridderstaat, Carissa Baker, Alan Fyall

Faculty Scholarship and Creative Works

COVID-19 has significantly influenced tourism, including tourists’ and residents’ attitudes toward tourism. At the same time, attitudes and consumer confidence are important for economic recovery in the tourism sector. This study explores the effects of the COVID-19 pandemic on people’s attitudes toward tourism by analyzing time-series data on the number of COVID-19 positive cases, vaccinations, news sentiment, a total number of daily mentions of tourism, and the share of voice for positive and negative sentiment toward tourism. The applied data analysis techniques include descriptive analysis, visual representation of data, data decomposition into trend and cycle components, unit root tests, Granger …

2021-10-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Psychosocial Factors Associated With Mask-Wearing Behavior During The Covid-19 Pandemic, Cliff (Yung-Chi) Chen, Mengjia Lei

Publications and Research

Although increasing evidence has supported the efficacy of masks to prevent the spread of the coronavirus (COVID-19), inconsistent and noncompliant mask-wearing behavior has been observed among members of the society. Because mask-wearing is often considered a social contract, it is important to understand the psychosocial factors that influence people’s mask-wearing behavior in order to implement the necessary steps to respond to the pandemic. Based on the protection motivation theory (PMT), this study examined the cognitive factors (threat and coping appraisals) that contribute to mask-wearing behavior and the intention to engage in health protective behavior until the end of the pandemic. …

Hand Hygiene And Hospital-Acquired Infections During Covid-19 Increased Vigilance: One Hospital’S Experience, Alexander Kong, Carlos S. Botero Suarez, Bebe Rahamatalli, Jennifer Shankweiler, Olga Karasik

HCA Healthcare Journal of Medicine

Background

Hospital-acquired infections are associated with increased morbidity, mortality, costs and length of stay. Prior studies have linked increased hand hygiene compliance with reduced hospital-acquired infection rate. With the increased vigilance for personal and institutional hygiene practices during the COVID-19 pandemic, we hypothesized increased hand hygiene compliance and, as a result, decrease in hospital-acquired infections in our hospital.

Methods

Hand hygiene compliance data was provided by the hospital’s Quality Department. We queried and empirically analyzed local hospital-acquired infection data obtained from our Quality Department and the National Healthcare Safety Network. We compared local hand hygiene compliance rates before and after …

2021-10-29_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Digital Technology And Disease Surveillance In The Covid-19 Pandemic: A Scoping Review Protocol, Lorie Donelle, Jodi Hall, Brad Hiebert, Jacob J. Shelley, Maxwell J. Smith, Jason Gilliland, Saverio Stranges, Anita Kothari, Jacquelyn Burkell, Tommy Cooke, Jed Long, James M. Shelley, Deanna Befus, Leigha Comer, Marionette Ngole, Meagan Stanley

Paediatrics Publications

Introduction Infectious diseases pose a risk to public health, requiring efficient strategies for disease prevention. Digital health surveillance technologies provide new opportunities to enhance disease prevention, detection, tracking, reporting and analysis. However, in addition to concerns regarding the effectiveness of these technologies in meeting public health goals, there are also concerns regarding the ethics, legality, safety and sustainability of digital surveillance technologies. This scoping review examines the literature on digital surveillance for public health purposes during the COVID-19 pandemic to identify health-related applications of digital surveillance technologies, and to highlight discussions of the implications of these technologies. Methods and analysis …

Laboratory Diagnostic Testing For Covid-19, Nuntra Suwantarat, Sidayu Suriya

Asian Medical Journal and Alternative Medicine

Laboratory tests play an important role for Corona Virus Disease 2019 (COVID-19) diagnosis. The diagnostic key point is an appropriate testing during the course of disease. In the early course of COVID-19 infection, nucleic acid amplification tests (NAATs) especially real-time reverse-transcription polymerase chain reaction (RT-PCR) of the respiratory specimen is the gold standard test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection due to the highest sensitivity and specificity during the first 2 weeks after the exposure. A rapid antigen test for SARS-CoV-2 has less complexity of the testing procedure and the faster TAT. However, a rapid antigen test …

Gastrointestinal And Liver Manifestations Of Covid-19, Keerati Kiattikunrat, Sith Siramolpiwat

Asian Medical Journal and Alternative Medicine

Almost every country in the world has been affected by the pandemic of Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first reported in Wuhan, China, in December 2019. The clinical manifestation is diverse, ranging from asymptomatic to severe pneumonia requiring mechanical ventilation. In addition, gastrointestinal symptoms have also been reported to occur during the course of the disease. In some patients, gastrointestinal symptoms may precede respiratorytract symptoms. Interestingly, the SARS-CoV-2 RNA could be detected in the stool of COVID-19 patients, implying that SARS-CoV-2 may be transmitted by fecal-oral route. Moreover, mild transient abnormal liver …

Covid-19 In Children, Pornumpa Bunjoungmanee, Detchvijitr Suwanpakdee

Asian Medical Journal and Alternative Medicine

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic in many countries necessitating the employment of massive public health responses. Clinical manifestations of children with COVID-19 are typically less severe than adult patients. Most children with COVID-19 remain asymptomatic or become mildly symptomatic. However, children can also get severely ill from COVID-19. Infants who are under the age of one year and children with preexisting comorbidities may be more likely to develop severe illness and are at an increased risk for hospitalization and critical care. Rarely, COVID-19 may result in multisystem inflammatory syndrome …

Current And Repurposing Medication For Sars-Cov-2 Infection, Kittiya Jantarathaneewat, Korakoch Kangwantas, Nattapong Tidwong

Asian Medical Journal and Alternative Medicine

In the crisis of COVID-19 pandemic, there is no specific agent to treat SARS-CoV-2 infection. Repurposing medication can be an alternative agent. Remdesivir is the first antiviral drug that has been approved for COVID-19 treatment whereas lopinavir/ritonavir and hydroxychloroquine, which was early used in SARS-CoV-2 widespread, are against by well-known guidelines due to lack of efficacy and potential toxicity. Corticosteroids are an essential supportive care in COVID-19 patient with severe disease to reduce lung inflammation. Favipiravir may have a potential benefit for COVID-19 patient, but the data is still uncertain. Ivermectin, an antihelmintic agent, may be used against SARS-CoV-2 but …

Digital Technology And Disease Surveillance In The Covid-19 Pandemic: A Scoping Review Protocol, Lorie Donelle Phd, Rn, Fcan, Jodi Hall, Brad Hiebert, Jacob J. Shelley, Maxwell J. Smith, Jason Gilliland, Saverio Stranges, Anita Kothari, Jacquelyn Burkell, Tommy Cooke, Jed Long, James M. Shelley, Deanna Befus, Leigha Comer, Marionette Ngole, Meagan Stanley

Publications

INTRODUCTION: Infectious diseases pose a risk to public health, requiring efficient strategies for disease prevention. Digital health surveillance technologies provide new opportunities to enhance disease prevention, detection, tracking, reporting and analysis. However, in addition to concerns regarding the effectiveness of these technologies in meeting public health goals, there are also concerns regarding the ethics, legality, safety and sustainability of digital surveillance technologies. This scoping review examines the literature on digital surveillance for public health purposes during the COVID-19 pandemic to identify health-related applications of digital surveillance technologies, and to highlight discussions of the implications of these technologies. METHODS AND ANALYSIS: …

Covid-19 Treatment, Suttichai Visuttichaikit

Asian Medical Journal and Alternative Medicine

The ongoing outbreak of COVID-19 has posed a great threat to public health. The various degree and dynamic of illness severity, together with the fact that only few drugs have been proven as an effective therapy has created critical challenges in disease management. Patients in acute viral phase usually present with upper respiratory tract and/or gastrointestinal illness, fever, and myalgia. Antiviral therapy might provide the greatest benefit in reducing disease progression in such patients with older age or significant comorbidities while immunomodulators are less likely to provide advantages. Patients in immune dysregulation phase usually present with pneumonia of different severity. …

Data-Driven Transmission Patterns Of Covid-19 In Asean+6, Panyawut Sri-Iesaranusorn, Amornpong Trakarnkulphun, Attawit Chaiyaroj, Decho Surangsrirat

Asian Medical Journal and Alternative Medicine

Introduction: Our objective is to discover transmission patterns of COVID-19 in the group of 16 countries called ASEAN+6 which comprise the ten countries in ASEAN and China, Japan, South Korea, Australia, New Zealand, and India.

Methods: The public dataset from John Hopkins University was used in this work. The concept of the effective reproduction number (ℛ) based on the SIR model is used to define the wave of infection. K-means clustering, an unsupervised machine learning algorithm, is then applied to the time-series data to divide the waves into clusters.

Results: The data of the confirmed cases and fatalities were separated …