Digital Commons Network^™

Due Diligence In A Pandemic: State Accountability For Covid-19 Under International Law, Andrea Cocchini, Gonzalo Villalta Puig

Indiana Journal of Global Legal Studies

The coronavirus disease 2019 pandemic has tested the response capacity of the international community. This article analyses the due diligence principle and the various international legal instruments that restate it in an assessment of the possible actions that states could have taken to avoid or, at least, contain the initial outbreak of the pandemic.

Diagnostic Utility Of Il-6 And Some Biomarker Correlated With The Diseases Severity Of Covid‐19 Patients, Ekhlas Saddam Falih, Suhad Hassan Obaid

Al-Nisour Journal for Medical Sciences

Coronavirus disease 2019 (COVID-19) SARS-2 is a respiratory tract infection with a newly recognized coronavirus thought to have originated as a zoonotic virus that has mutated or otherwise adapted in ways that allow human pathogenicity. This study describe the association between IL-6, D-dimer, C-reactive protein (CRP, Ferritin, erythrocyte sedimentation rate (ESR), and hematological marker in a cohort of COVID-19 patients. The baseline characteristics of the studied samples according to age and gender with a comparison of significance in studied groups show that a total of 65 individuals were divided into three groups according to the severity of disease (17 milds, …

The Case For A Global Excess Profits Tax: A Response To Dr. Tarcísio Diniz Magalhães & Professor Allison Christians, Paige Powers

Indiana Journal of Global Legal Studies

In striving to slow the spread of the COVID-19 pandemic, governments across the globe acted quickly to implement various "stayat- home" orders and bans on all "non-essential activities." While these actions were likely effective in slowing the spread of the virus, the economic impacts were felt almost immediately. The US deficit rose to $3.1 trillion following massive spending to aid individuals and small businesses. Internationally, governments have been increasing their debt loads to combat both the health and financial impacts of the pandemic. Indeed, by the end of 2020, the international debt load increased to a record-breaking $281 trillion. Almost …

Local Broadcast Reporters Maintaining Social Responsibility And Mental Health While Serving A Community Under Lockdown, Mary-Morgan Ellis

Graduate Theses and Dissertations

This study looks at local broadcast news reporters working in Northwest Arkansas before, at the start, and during the COVID-19 global pandemic. Research for this study includes a content study of the tweets and Twitter accounts of eleven local reporters. This study considers the social responsibility theory and examines how these eleven local reporters use the theory in their everyday work. Research found, though these reporters don’t credit the theory by name, they are still putting its guidelines into effect as a sort of moral compass when creating objective and representative news for their communities. The research also found that …

Coping And Adjustment During Covid-19: Experiences Of Chinese International Doctoral Students In The United States

Journal of Comparative & International Higher Education

No abstract provided.

Regression Analysis Of Resilience And Covid-19 In Idaho Counties, Ishrat Zaman

Boise State University Theses and Dissertations

Global pandemic Coronavirus Disease 2019 (COVID-19) has serious harmful effects on our day-to-day lives. To overcome challenges such as this, critical preparedness, readiness, and response actions are required. This thesis uses estimates of community resilience available through the CRE Tool, published by the US Census Bureau, and COVID19 cases published by John Hopkins Coronavirus Research Center for Idaho counties. Simple linear regression analysis was performed to identify a correlation between COVID-19 cases and deaths in Idaho counties and measures of their resilience. Understanding this correlation could lead to better estimation and prediction of the effect of disasters in Idaho’s counties. …

Genome-Wide Bidirectional Crispr Screens Identify Mucins As Host Factors Modulating Sars-Cov-2 Infection, Scott B Biering, Sylvia A Sarnik, Eleanor Wang, James R Zengel, Sarah R Leist, Alexandra Schäfer, Varun Sathyan, Padraig Hawkins, Kenichi Okuda, Cyrus Tau, Aditya R Jangid, Connor V Duffy, Jin Wei, Rodney C Gilmore, Mia Madel Alfajaro, Madison S Strine, Xammy Nguyenla, Erik Van Dis, Carmelle Catamura, Livia H Yamashiro, Julia A Belk, Adam Begeman, Jessica C Stark, D Judy Shon, Douglas M Fox, Shahrzad Ezzatpour, Emily Huang, Nico Olegario, Arjun Rustagi, Allison S Volmer, Alessandra Livraghi-Butrico, Eddie Wehri, Richard R Behringer, Dong-Joo Cheon, Julia Schaletzky, Hector C Aguilar, Andreas S Puschnik, Brian Button, Benjamin A Pinsky, Catherine A Blish, Ralph S Baric, Wanda K O'Neal, Carolyn R Bertozzi, Craig B Wilen, Richard C Boucher, Jan E Carette, Sarah A Stanley, Eva Harris, Silvana Konermann, Patrick D Hsu

Faculty, Staff and Student Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2-host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2. We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a …

Could Cultures Determine The Course Of Epidemics And Explain Waves Of Covid-19?, Md Salman Rahman

Theses and Dissertations

Coronavirus Disease (COVID-19), caused by the SARS-CoV-2 virus, is an infectious disease that quickly became a pandemic spreading with different patterns in each country. Travel bans, lockdowns, social distancing, and non-essential business closures caused significant economic disruptions and stalled growth worldwide in the pandemic’s first year. In almost every country, public health officials forced and/or encouraged Nonpharmaceutical Interventions (NPIs) such as contact tracing, social distancing, masks, and quarantine. Human behavioral decision-making regarding social isolation significantly impedes global success in containing the pandemic. This thesis focuses on human behaviors and cultures related to the decision-making of social isolation during the pandemic. …

The Role Of Middle And High School Principals During The Covid-19 Pandemic: A Phenomenological Study, Dustin Ford

Electronic Theses and Dissertations

The purpose of this qualitative study was to examine middle and high school principal roles prior to and during the COVID-19 pandemic to gain a better understanding about how leadership responsibilities adapted or changed. Data collection strategies included one-on-one interviews with nine middle and high school principals in East Tennessee. To qualify for the study participants had to have experience in the principalship prior to the pandemic. The analysis of data was based on the theoretical frameworks of adaptive leadership (Heifetz et al., 2009) and change theory (Fullan, 2020). The results revealed five key themes that were consistent during the …

Relationships Between Covid-19 Infection Rates, Healthcare Access, Socioeconomic Status, And Cultural Diversity, Marghece P. J. Barnes

Boise State University Theses and Dissertations

The COVID-19 pandemic has had a disproportionate impact on racial and ethnic minority groups, with high infection rates throughout those communities. There are a complex set of factors that account for COVID-19 disparities. Focusing on infection and death rates alone without also examining health equity, underestimates the true impact of the pandemic. To gain a more clear understanding of COVID-19’s impact in these communities, we analyzed the relationship between state COVID-19 infection rates with social determinants of health: cultural diversity, health care access, and socioeconomic status. Our approach to identifying this relationship was to estimate infection rates by fitting John …

A Systematic Review And Meta-Analysis On Prevalence Of And Risk Factors Associated With Depression, Anxiety And Insomnia In Infectious Diseases, Including Covid-19: A Call To Action, Kai Yuan, Yong-Bo Zheng, Yi-Jie Wang, Yan-Kun Sun, Yi-Miao Gong, Yue-Tong Huang, Xuan Chen, Xiao-Xing Liu, Yi Zhong, Si-Zhen Su, Nan Gao, Yi-Long Lu, Zhe Wang, Wei-Jian Liu, Jian-Yu Que, Ying-Bo Yang, An-Yi Zhang, Meng-Ni Jing, Chen-Wei Yuan, Na Zeng, Michael V Vitiello, Vikram Patel, Seena Fazel, Harry Minas, Graham Thornicroft, Teng-Teng Fan, Xiao Lin, Wei Yan, Le Shi, Jie Shi, Thomas Kosten, Yan-Ping Bao, Lin Lu

Children’s Nutrition Research Center Staff Publications

Infectious disease epidemics have become more frequent and more complex during the 21st century, posing a health threat to the general public and leading to psychological symptoms. The current study was designed to investigate the prevalence of and risk factors associated with depression, anxiety and insomnia symptoms during epidemic outbreaks, including COVID-19. We systematically searched the PubMed, Embase, Web of Science, OVID, Medline, Cochrane databases, bioRxiv and medRxiv to identify studies that reported the prevalence of depression, anxiety or insomnia during infectious disease epidemics, up to August 14th, 2020. Prevalence of mental symptoms among different populations including the general public, …

Covid-19 Vaccines And Related Adverse Effects Among Health Sciences And Non-Health Sciences Students From Two Large Public Universities In Thailand, Thana Khawcharoenporn, Kanathip Jongmekwamsuk, Sirashat Hanvivattanakul, Jakaphat Vanichanan

Asian Medical Journal and Alternative Medicine

Introduction: Existing data on vaccine regimensreceived by university students and related adverse effects (AEs) are limited.

Objectives: To assess types and AEs of COVID-19 vaccines received by Thai university students.

Methods: An online survey study was conducted among students from 12 Health Sciences faculties (HS), and from 16 non-Health Sciences faculties (NHS) of two universities from October 2021 to January 2022.

Results: There were 1,439 participating students; 522 (36%) were HS and 917 (64%) were NHS. The types of the first-dose vaccine received were inactivated (49%), viral vector (VV; 46%), and mRNA (5%), while the types of the second-dose vaccine …

Ocular Symptoms Assessment Of Covid-19: A Cross-Sectional Study, Wimolwan Tangpagasit, Sasivarin Luangpitakchumpol, Kritrath Panittaveekul

Asian Medical Journal and Alternative Medicine

Introduction: The coronavirus disease 2019 (COVID-19) is an emerging lower respiratory tract infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Objectives: This research was purposed to assess the clinical manifestations of COVID-19 infection and the characteristics of ocular involvement.

Methods: This study is a cross-sectional quantitative study, an online questionnaire was performed on RT-PCR positive COVID-19 patients in Thailand.

Results: A total of 168 COVID-19 patients (32.3% male and 67.7% female) were enrolled in the study and completed an online questionnaire. The mean age of the patients was 39.14 ±12.7 years (ranging from 18 to 72 years). …

Real-Life Covid-19 Vaccine Effectiveness And Risk Factors Of Covid-19 Infection During Omicron Variant Epidemic In Thailand, Paskorn Sritipsukho, Thana Khawcharoenporn, Pichaya Tantiyavarong, Boonying Siribumrungwong, Pansachee Damronglerd, Nuntra Suwantarat, Araya Satdhabudha, Chanapai Chaiyakulsil, Phakatip Sinlapamongkolkul, Auchara Tangsathapornpong, Pornumpa Bunjoungmanee

Asian Medical Journal and Alternative Medicine

Introduction: Data of real-life vaccine effectiveness (VE) and risk factors of COVID-19 infection during Omicron variant epidemic in Thailand are limited.

Methods: A test-negative case-control design was conducted to assess the VE for each dose of vaccination during the omicron variant epidemic (1 Jan to 30 April 2022). Available vaccine regimensin Thailand mainly consisted of inactivated vaccine (CoronaVac, SV), viral vector vaccine (ChAdOx1,AZ), and mRNAvaccine (BNT162b2, PF and Spikevax, MDN). All patients under investigation (PUI), aged more than 5 years, presenting at Thammasat University (TU) hospital for nasopharyngeal real-time polymerase chain reaction (RT-PCR) testing were prospectively enrolled and followed-up for …

Are Kenyans Likely To Use Covid-19 Self-Testing Kits? Results From A Cross-Sectional Survey, Griffins Manguro, Sonjelle Shilton, Sharon Omenda, Patrica Owira, Deepshikha Batheja, Abhik Banerji, Sophie Chabeda, Marleen Temmerman, Walter Jako, Stanley Luchters

Obstetrics and Gynaecology, East Africa

Objectives: To understand the public’s perceptions around rapid SARS-CoV-2 antigen self-testing in Kenya, including the drivers of acceptability, willingness to pay, and adherence to hygiene and prevention recommendations following a positive self-test.

Methods: A household-based, cross-sectional survey, using a 35-item questionnaire, was conducted in Mombasa and Taita–Taveta counties, Kenya, during August 2021. Individuals aged ≥18 years were enrolled using a stratified sampling approach.

Results: There were 419 participants (mean age 35.7 years). A minority (10.5%) had ever tested for SARS-CoV-2. If SARS-CoV-2 self-testing were available, 39.9% and 41.5% would be likely and very likely, respectively, to use it. If unavailable …

Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya

The Thai Journal of Pharmaceutical Sciences

Diabetes is the third most customary non-infectious disease occurring worldwide and leads to untimely disability and mortality. This metabolic disorder is characterized by impaired insulin secretions and high blood glucose levels. Among others, type 2 diabetes is the most common. Various chemical and biochemical hypoglycemic drugs are utilized to control and treat hyperglycemia but required further interventions to reduce their toxicity and side effects on the users. Edible mushrooms have been employed from ancient times to heal many diseases as it composed of anti-oxidant, alkaloids, fibers, triterpenoids, and other phytochemicals. The bioactive secondary metabolites of mushrooms can improve insulin resistance …

Reflections On The Adaptation Of A Postgraduate Degree In Water Management From In-Person To Remote Delivery, Murray Clamen, Emma Anderson, Johanna Dipple, Jan Adamowski

Journal of Contemporary Water Research and Education

In early 2020, the COVID-19 pandemic spurred the rapid adaptation of university course delivery to an online format. Though in-person delivery partially resumed in the Fall of 2021, future conditions may favor a return to, or addition of, remote delivery. It is therefore important for instructors, program directors, and institutions to capitalize on this learning opportunity and reflect on adaptation measures’ successes (and failures) to inform future online course design. The reworking of McGill University's Master of Science Program in Integrated Water Resources Management (IWRM) provides a case study to evaluate the adaptation of remote teaching of water resource management. …

Antibody Evasion By Sars-Cov-2 Omicron Subvariants Ba2121, Ba4 And Ba5, Qian Wang, Yicheng Guo, Sho Iketani, Manoj S Nair, Zhiteng Li, Hiroshi Mohri, Maple Wang, Jian Yu, Anthony D Bowen, Jennifer Y Chang, Jayesh G Shah, Nadia Nguyen, Zhiwei Chen, Kathrine Meyers, Michael T Yin, Magdalena E Sobieszczyk, Zizhang Sheng, Yaoxing Huang, Lihong Liu, David D Ho

Faculty, Staff and Student Publications

SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 have surged notably to become dominant in the United States and South Africa, respectively1,2. These new subvariants carrying further mutations in their spike proteins raise concerns that they may further evade neutralizing antibodies, thereby further compromising the efficacy of COVID-19 vaccines and therapeutic monoclonals. We now report findings from a systematic antigenic analysis of these surging Omicron subvariants. BA.2.12.1 is only modestly (1.8-fold) more resistant to sera from vaccinated and boosted individuals than BA.2. However, BA.4/5 is substantially (4.2-fold) more resistant and thus more likely to lead to vaccine breakthrough infections. Mutation at spike …

Microplastics In Freshly Fallen Snow: How May It Adversely Impact Human Health And Exacerbate The Covid-19 Crisis?, Ayesha Liaquat, Aleena Kashif, Sushma Rathi, Alishba Raza

Medical College Documents

No abstract provided.

Mathematical Modeling Of Seir Model With Generalized Incidence Function And The Extension To Covid-19 Model, Shymaa Mohammad Dadoa

Theses

The COVID-19 pandemic had shown the importance of the SEIR model in predicting the outcome of the disease spread and to find the best strategies to contain the pandemic. As this type of model has a limited number of compartments, many other models were derived from the SEIR model to cover, to the maximum, the complex dynamics of the disease spread. These extensions of the SEIR model bring natural validity questions: How can we validate these models? and how far/close are these extended models from giving us real insights into the pandemic?

This thesis investigates the SEIR epidemic model and …

Cyberchondria And Covid-19 Health Threats Related To Attentional Bias And Safety Behaviors, Jacqueline J. Charles

Electronic Theses and Dissertations

Cyberchondria is described as excessively searching online for health information that ultimately increases worry and anxiety about one’s health (Starcevic et al., 2019). Research has demonstrated an increased attentional bias in anxious individuals for threat-related stimuli. Attentional bias for health information exacerbated by the frequent exposure to health threats during the COVID-19 pandemic may contribute to additional health-seeking behavior. The current study aimed to explore the potential relationship between COVID-19 health threats and cyberchondria level on attentional bias toward illness-related stimuli (symptom words) and the intent to perform safety behaviors while controlling for Trait Anxiety and Health Anxiety. Participants ( …

Social Contributors For The Rise Of Covid-19 Infections In South Asia: A Large Cross-Sectional Survey, Zouina Sarfraz, Azza Sarfraz, Muzna Sarfraz, Nishwa Azeem, Namrata Hange, Miguel Felix, Ivan Cherrez-Ojeda

Department of Paediatrics and Child Health

Background: The ongoing global coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first reported in South Asia on 30th January 2020 in India. Ever since, certain countries have witnessed multiple waves of COVID-19, requiring attention by public health experts and strategists in the region. The objectives of this study are to assess social contributors to the recurrent waves of COVID-19 in South Asia including first demographic traits, second household characteristics and social measures, third workplace trends and personal protective equipment use, and fourth satisfaction and attitudes concerning public health measures and vaccination status. …

Quantifying Inequities In Covid-19 Vaccine Distribution Over Time By Social Vulnerability, Race And Ethnicity, And Location: A Population-Level Analysis In St. Louis And Kansas City, Missouri, Aaloke Mody, Cory Bradley, Salil Redkar, Branson Fox, Ingrid Eshun-Wilson, Matifadza G. Hlatshwayo, Anne Trolard, Khai Hoan Tram, Lindsey M. Filiatreau, Franda Thomas, Matt Haslam, George Turabelidze, Vetta Sanders-Thompson, William G. Powderly, Elvin H. Geng

2020-Current year OA Pubs

BACKGROUND: Equity in vaccination coverage is a cornerstone for a successful public health response to COVID-19. To deepen understanding of the extent to which vaccination coverage compares with initial strategies for equitable vaccination, we explore primary vaccine series and booster rollout over time and by race/ethnicity, social vulnerability, and geography.

METHODS AND FINDINGS: We analyzed data from the Missouri Department of Health and Senior Services on all COVID-19 vaccinations administered across 7 counties in the St. Louis region and 4 counties in the Kansas City region. We compared rates of receiving the primary COVID-19 vaccine series and boosters relative to …

Covid-19 In Indonesia: Is There A Shift From Pandemic To Endemic?, Laily Hanifah, Kemal N. Siregar

Kesmas

The world is still facing the Coronavirus Disease 2019 (COVID-19) pandemic, and the current challenge is the epidemic, which was thought to have become endemic, but it seems far from that. This article describe the recent progress of the COVID-19 globally, including in Indonesia, and what should be done towards building community health resilience. Each day, more than 500,000 new cases are being detected worldwide. This condition shows that the present pandemic is not over and still requires global vigilance. The challenge faced by the world, and Indonesia, is to develop resilient communities as a prerequisite to controlling any future …

Measuring The Success Of Pedulilindungi Application Use For Supporting Covid-19 Prevention: A Case Study Among College Students In Jakarta, Indonesia, Mochamad Iqbal Nurmansyah, Catur Rosidati, Yustiani Yustiani, Narila Mutia Nasir

Kesmas

The Indonesian Government has launched PeduliLindungi (PL) mobile apps as a COVID-19 preventive tool. This study aimed to describe the PL utilization and determine the factors influencing its successful use among college students. This study used a cross-sectional design and a total population sampling at a university in the Special Capital Region of Jakarta, Indonesia. The Delone and Mclean Information System Success Model was adopted to measure the use of the apps. The Spearman’s rank correlation test was performed to determine the relationship between two variables. Furthermore, 354 respondents participated in this study. The respondents used the apps mostly to …

Covid-19 Prevention And Control: Mining Industry Responses To The Pandemic, Arif Susanto, Agra Mohamad Khaliwa, Muhamad Razif Iqbal, Edi Karyono Putro, Asep Dian Abdilah

Kesmas

The rapidly growing global Coronavirus Disease 2019 (COVID-19) pandemic crisis affects the labor-intensive mining industry. The industry is characterized by high worker mobility and 24-hour operations; thus, this continuous, mobile workforce increases the transmission risk of COVID-19 and has been a challenge for the mining industry during the pandemic. PT X, one of the largest mineral mining locations in Mimika District, Central Papua Province, Indonesia, was challenged to face the COVID-19 pandemic crisis. Therefore, this qualitative study aimed to analyze the COVID-19 handling efforts by PT X Concentrating Division using a descriptive-analytical method to describe the completion of PT X. …

Susceptibility Antibiotics Of Bacteria Causing Urinary Tract Infection In Pregnant Women Infected With Covid-19, Rashid Rahim Hateet

Kesmas

Urinary tract infections (UTIs) are a significant issue in women of all ages, but they are especially common during pregnancy. Co-infection of the Coronavirus Disease 2019 (COVID-19) with UTIs in pregnant females is a hot topic today, as it may be linked to various conditions. Furthermore, understanding the types of bacteria that cause UTIs and related antimicrobial resistance may aid the clinician in selecting the appropriate empirical treatment. This study aimed to isolate and characterize causative agents of UTIs and determine antimicrobial treatment sensitivity patterns among pregnant women diagnosed with the COVID-19 admitted to Teaching Hospital X in Iraq. Antimicrobial …

Role Of Community Leaders In Managing Covid-19 Pandemic In Indonesia, Nur Alvira Pascawati, Tri Baskoro Tunggul Satoto, Annisa Rizqa Alamri

ASEAN Journal of Community Engagement

Community leaders must understand their role in controlling COVID-19, such as monitoring misleading information and providing socialization, education, protection, monitoring, and evaluation activities in the community, due to the numerous limitations of local governments in managing large populations during this crisis. This study aimed to describe the role of Yogyakarta community leaders in increasing community engagement in managing the Covid-19 pandemic. This study uses a quantitative method with a cross-sectional approach, and the study sample includes all community leaders as many as 31 people at the levels of neighborhood and hamlet. The data analysis process uses frequency distribution values. Results …

Comprehensive Efforts To Accelerate Non-Communicable Disease Services In The Era Of Covid-19 In Indonesia’S Suburban Area, Akmal Taher, Soehartati A. Gondhowiardjo, Adang Bachtiar, Sabarinah Prasetyo, Irene Pixelyne, Ficky Huang, Rima Sumayyah Ahmad

ASEAN Journal of Community Engagement

The COVID-19 crisis has disrupted non-communicable disease (NCD) services in primary health care, and NCD is one of the comorbidities that increase mortality in COVID-19 patients. Efforts to accelerate NCD services were carried out with the focus on two programs: the development of integrated polyclinic NCD services and the training of community health workers (CHW) at the Tanara Community Health Center (CHC) in Banten. The development of a continuous team-based service system from the Pos Pembinaan Terpadu (Posbindu)/integrated service post to NCD services at the CHC was carried out for six months to improve the quality of human resources and …

Confirming Multiplex Rt-Qpcr Use In Covid-19 With Next-Generation Sequencing: Strategies For Epidemiological Advantage, Rob E. Carpenter, Vaibhav Tamrakar, Harendra Chahar, Tyler Vine, Rahul Sharma

Human Resource Development Faculty Publications and Presentations

Rapid identification and tracking of emerging SARS-CoV-2 variants are critical for understanding the transmission dynamics and developing strategies for interrupting the transmission chain. Next-Generation Sequencing (NGS) is an exceptional tool for whole-genome analysis and deciphering new mutations. The technique has been instrumental in identifying the variants of concern (VOC) and tracking this pandemic. However, NGS is complex and expensive for large-scale adoption, and epidemiological monitoring with NGS alone could be unattainable in limited-resource settings. In this study, we explored the application of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) based detection of the variant identified by NGS. We analyzed a total …