Digital Commons Network^™

Secretion Of Von Willebrand Factor And Suppression Of Adamts-13 Activity By Markedly High Concentration Of Ferritin, Dalia A Bashir, Qi Da, Subhashree Pradhan, Nitin Sekhar, Christian Valladolid, Fong Lam, Danielle Guffey, Jordana Goldman, Moreshwar S Desai, Miguel A Cruz, Carl Allen, Trung C Nguyen, K Vinod Vijayan

Faculty, Staff and Students Publications

Hyperferritinemia is associated with poor outcomes in critically ill patients with sepsis, hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndromes (MAS) and coronavirus disease 19 (COVID-19). Autopsies of hyperferritinemic patients that succumbed to either sepsis, HLH, MAS or COVID-19 have revealed disseminated microvascular thromboses with von Willebrand factor (VWF)-, platelets-, and/or fibrin-rich microthrombi. It is unknown whether high plasma ferritin concentration actively promotes microvascular thrombosis, or merely serves as a prognostic biomarker in these patients. Here, we show that secretion of VWF from human umbilical vein endothelial cells (HUVEC) is significantly enhanced by 100,000 ng/ml of recombinant ferritin heavy chain protein (FHC). …

Second Thoughts On Fda's Covid-Era Mental Health App Policy, Michael Mattioli

Articles by Maurer Faculty

As the coronavirus pandemic swept across the globe in April 2020, the US Food and Drug Administration (FDA) made an unusual decision. The agency announced that it would relax its enforcement of compliance rules for “digital therapeutics”—smartphone apps designed to address mental health disorders. The measure was a response to widely reported upticks in symptoms of anxiety, depression, and substance abuse brought on by the pandemic. As an added benefit, the agency explained, digital therapeutics could promote social distancing by removing patients’ need to visit health care providers.

This essay explores the possible lasting effects of the FDA’s temporary suspension …

Access To Technology In Humboldt County: Measuring Digital Preparedness At The Start Of A Pandemic, Lauren E. Proffitt

Cal Poly Humboldt theses and projects

This research is based on summer 2020 online survey data from a stratified random sample of 573 clients and care providers of a rural Northern California government social services agency. The goal was to study information technology access in Humboldt County, California, and the range of digital preparedness of clients of a local government agency: Humboldt County In-Home Supportive Services (IHSS). IHSS serves several groups of rural residents with low-income, foremost of which are older adults and people with disabilities. In 2020, in compliance with federal requirements, IHSS discontinued systems for paper-based client/provider confirmation of services, moving to digital technology-based …

Assessing California Commercial Fishing Community Well-Being In The Context Of Marine Protected Area (Mpa) Formation, Samantha Cook

Cal Poly Humboldt theses and projects

Marine protected areas (MPAs)—defined geographic areas where fishing and harvesting activity is limited or restricted—have emerged as a popular marine biodiversity and climate resilience strategy worldwide. MPA monitoring efforts often follow MPA designation to help inform the adaptive management of MPAs and MPA networks. In 2012, California completed the largest statewide system of MPAs to date, consisting of 124 MPAs covering 16% of state waters. Following MPA implementation, the state initiated a long-term monitoring program (2019-2022) to help inform the 10-year MPA management review. This two-chapter thesis presents findings from a state-funded project to conduct long-term socioeconomic monitoring for human …

Caution Fatigue: Group Identification And Disgust Provide Protection In The Covid-19 Pandemic, Logan F. Ashworth

Cal Poly Humboldt theses and projects

The current Coronavirus pandemic has yielded an abundance of concerns regarding the psychological effects of isolating a highly social species through widespread lockdowns and enhanced social distancing. Research show that many are suffering from mental health crises, while also refusing to isolate (Brooks et al., 2020; Czeiler, et al., 2020). These behaviors combine to increase risk of viral infection. An emerging term to explain this paradox is “Caution Fatigue”. Yet, there is no research that outlines its specific underlying mechanisms. The goal of this paper is to propose a series of models that delineate caution fatigue through the effects a) …

Still Learning: Covid Through The Eyes Of A Medical Student, Alexis Strahan

HCA Healthcare Journal of Medicine

As a first-year medical student when the COVID-19 pandemic found a foothold, I felt an overwhelming amount of emotions that accompanied the pandemic’s spread. Fear, although a reasonable choice, was not the first emotion that I experienced. In fact, it was a general feeling of paralysis. I had not six months prior taken an oath to commit my career and life to the service of the public’s health care needs, yet I could provide little more than the textbook knowledge of biochemistry or genetics from my first semester of learning. My hands felt unarmed and unskilled for the fight. What …

Covid-19: Race For Vaccine, L. Hayley Burgess, Jason J. Braithwaite, Emily Singleton, Aaron M. Young, Mandelin K. Cooper

HCA Healthcare Journal of Medicine

The world is in the midst of a pandemic from COVID-19, a disease caused by the virus SARS-CoV-2. Despite broad mitigation efforts, new cases continue with 74 million cases and 1.6 million deaths worldwide. Regardless of previous research efforts, there is no commercially available vaccine for any coronavirus. Novel vaccine development has historically taken at least 10 years from discovery to availability with only a 6% market entry probability.

With the global impact, there is an urgency to expedite a vaccine to protect the population. The U.S. government launched Operation Warp Speed with the goal to produce and deliver 300 …

Importance Of Awareness Of Adverse Drug Reaction Reporting During The Covid-19 Pandemic, Heather Ellis, Hale Z. Toklu

HCA Healthcare Journal of Medicine

Health care professionals hold the responsibility of reporting any adverse drug reactions in order to learn about new therapy and how best to safely care for our patients. The information derived from case publications and FDA MedWatch reports are essential to accumulate information and increase awareness for the possible risks of new drugs.

Gender In The Time Of Covid-19: Evaluating National Leadership And Covid-19 Fatalities, Leah C. Windsor, Gina Yannitell Reinhardt, Alistair J. Windsor, Robert Ostergard, Susan Allen, Courtney Burns, Jarod Giger, Reed Wood

Social Work Faculty Publications

In this paper we explore whether countries led by women have fared better during the COVID-19 pandemic than those led by men. Media and public health officials have lauded the perceived gender-related influence on policies and strategies for reducing the deleterious effects of the pandemic. We examine this proposition by analyzing COVID-19-related deaths globally across countries led by men and women. While we find some limited support for lower reported fatality rates in countries led by women, they are not statistically significant. Country cultural values offer more substantive explanation for COVID-19 outcomes. We offer several potential explanations for the pervasive …

Law School Exams During A Pandemic: One Law School’S Experience, Beth Parker

Seattle Journal of Technology, Environmental, & Innovation Law

In 2020, toward the end of the spring semester, the COVID-19 pandemic disrupted life across the globe. Institutions, including law schools, felt the widespread effects of this public health crisis. Law schools were forced to move entire curriculums online in record time and consider how they were going to administer final exams. There is no precedent or manual for how to do this successfully. Law school exams are inherently stressful events in a law student’s career because their performance on the exam inordinately influences their grades and class rankings. Typically, law students are already on edge during final exams without …

Let Nutrition Be Your Vaccine Amid Covid-19- A Narrative Review, Vidya Rajesh

Manipal Journal of Medical Sciences

There has been a growing body of evidence highlighting the radical effect of nutrition on the immune system and disease susceptibility. The current COVID-19 crisis awakens an urgent calling for optimum nutrition which boosts immunity and prevents diseases, just like a vaccine. Though there have been several national guidelines regarding diet during COVID-19, there has been sparse research and literature available in this field. This review aims to summarise the existing evidence on various aspects of nutrition and immunity pertaining to the COVID-19 crisis. Literature and search strategy included PubMed and Google Scholar for articles on various aspects of nutrition …

“Sampark Snehi”: Telemedicine Consultation In Covid-19 Times At A Private Medical College Hospital – Digitalised Solution, Vijetha Belle

Manipal Journal of Medical Sciences

Every life is precious and every patient matters: In a country with 5.5 government beds for 10,000 population, even a marginal increase in hospitalization increases the pressure on the system exponentially. The spread of COVID-19 has kindled the need for transformation from traditional face-to-face doctorpatient communication to a telehealth platform. During the lockdown, reduced access to both outpatient and hospitalization services is proving to be fatal for countless non-covid patients. Taking lead in addressing the health care needs and demands of the society we cater to, E-consultation which has been initiated by most of the medical colleges providing tertiary care, …

The Legacy Of Racism And Covid-19, Adedayo Okanlawon

MEDI 9331 Scholarly Activities Clinical Years

This perspective piece discusses the interplay between Covid-19, the legacy of racism in America, and their synergistic effects on the black community. Personal racially charged experiences in conjunction with notable stories of injustice in medicine are used to set the stage. The pandemic's disparate impact on black communities are then discussed with suggestion on how to mitigate these issues.

Combating Covid-19 Infodemic In Nigerian Rural Communities: The Imperatives Of Traditional Communication Systems, Joseph M. Lucas, Tordue Simon Targema, Abubakar Jibril, Elkanah Obadiah Sambo, Bako Ali Istifanus

ASEAN Journal of Community Engagement

Since the outbreak of COVID-19 in December 2019, substantial attention has been devoted to combating the infodemic that has come to characterize it with the potential to prevent its effective containment. This is undoubtedly a very difficult task, especially in Nigerian rural communities that are characterized by severe lack of the requisite facilities to access information on modern media platforms, compounded by high illiteracy and poverty rates. This study presents a case for the utilization of people-oriented, traditional communication systems in combatting the infodemic at the grassroots level. It contends that, given the peculiarities of the country’s rural settlements, traditional …

Community Engagement In Covid-19 Responses: Evidence From Qualitative Interface With Community Opinion Leaders In Enugu, Nigeria, Prince Agwu, Chinweoke Methodius Ugwu, Chidera Florence Eke

ASEAN Journal of Community Engagement

Successful stories of community engagement existed during the Ebola disease outbreak in Liberia, indicating that a combination of government and community efforts are needed in addressing pandemics or epidemics. However, for communities to rise to the challenge of containing and combatting the spread of any disease, they must be communicated most effectively and supported by the government. Therefore, our study investigates how applicable successful community engagement has been in the charge against the Coronavirus disease 2019 (COVID-19) in Nigeria. Through telephone interviews, we sourced data from 12 community opinion leaders in Enugu State, Nigeria. After conducting a thematic analysis of …

The 21st Century Global Digital Economies Revolution And The Aftermath Of Covid-19 Pandemic: Some Anticipated Implication Changes For Developing Nations, Agyei Fosu

ASEAN Journal of Community Engagement

The 21^st century digital global economies era changed developmental approaches drastically to a point where most researchers, policy makers, and developers have asserted that to achieve economic development for developing nations; it is paramount for Information and Communications Technologies (ICTs) investments in all sectors contributing to their economy. The current COVID-19 pandemic and the various measures taken by governments such as lockdown, curfew, companies asking employees to work from home, and the use of e-learning by schools to curb the disease brings into perspective the assertion raised by various scholars about the need for developing nations to invest in …

“Why Can Other People Live Normally While I Cannot?”: An Application Of Telecounseling Due To Covid-19, Kusumasari Kartika Hima Darmayanti, Efan Yudha Winata, Erlina Anggraini

Makara Human Behavior Studies in Asia

In Nusa Tenggara Barat province, on May 04, 2020, there were 275 cases out of 11,587 total cases in Indonesia. COVID19 not only has an impact on physical health issues, but it also impacts on psychological issues. One of the psychological issues is how society experiences negative emotion (e.g., depression) during the spread of COVID-19. This study aimed to explore the telecounseling process on the individual who had experienced negative emotion especially in the case of depressive disorder in the COVID-19 Nusa Tenggara Barat province. This study used a single-case research design approach, and the collected data were analyzed qualitatively. …

Hubungan Motivasi Belajar Dengan Komunikasi Pembelajaran Sistem E-Learning Pada Mahasiswa Pgsd Di Masa Pandemi Covid-19, Anang Fathoni, Ali Mustadi, Wahyu Kurniawati

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This research aimed to determine the motivation of learning, communication of e-learning system, and relationship motivation learning and communication learning system of students of primary teacher Education, University PGRI Yogyakarta at the Covid-19 pandemic. This research used quantitative approaches with associative methods. The location of this research at PGRI University Yogyakarta with respondents amounted to 159 students of 2nd semester, consisting of 25 male students and 134 female students. The collection of research data used a questionnaire with a Likert rating scale. Analysis of data by using the correlation formula of product-moment from Pearson with the help of SPSS version …

Audits For The Minimization Of Eco-Anxiety In The World Economy, Karina Nazarova, Volodymyr Hordopolov, Mariia Nezhyva, Viktoriia Mysiuk, Tetiana Kopotiienko

Journal of Environmental Science and Sustainable Development

The global pandemic of 2019–2020 is changing not only the lives of citizens, but also approaches to business management. The activities of audit companies have not escaped. Problematic and debatable issues need to be addressed to formulate a comprehensive approach to audits in a transformative economic environment and minimize the global economy's eco-anxiety. The purpose of the article is to determine the role of the audit in minimizing the eco-anxiety of the world economy. The study's materials were indicators of the spread of the COVID-19 pandemic in the world, public writings of scientists, official reports of international organizations, regulations, and …

Potential Of Jamu In Nanotechnology Perspective As An Alternative Treatment For Covid-19, Dhadhang Wahyu Kurniawan, Azis Ikhsanudin

Pharmaceutical Sciences and Research

The world seems to be recovering at this time, especially because of the 2019 global coronavirus disease pandemic (COVID-19) caused by the Coronavirus 2 virus (SARS-CoV-2). This virus is similar to other β-coronaviruses through several steps to enter and bind angiotensin-converting enzyme 2 (ACE2) as the main receptor. This binding, particularly in the respiratory epithelium and alveoli of the lungs, affects harmony in human host cells. No specific vaccines and antivirals are available to date as drug investigations are still ongoing. However, many Indonesians consume herbal medicine, especially 'empon-empon' containing the Zingiberaceae family, to protect their health from COVID-19. So …

Socio-Demographic Determinants Of Indonesian Mothers’ Psychological Distress During Covid-19 Pandemic, Laila Qadariah, Fitri Ariyanti Abidin, Fitri Yustikasari Lubis, Vidya Anindhita

Makara Human Behavior Studies in Asia

The Indonesian government imposed a large-scale social restriction policy to prevent the spread of COVID-19. This policy affected the community, including mothers, and may have caused psychological strain on them. This study aimed to (i) establish a dataset on the psychological distress reported by mothers in Indonesia and (ii) identify demographic factors and pandemic-related characteristics that determine psychological distress. An online survey was administered from April 20 to April 25, 2020, and 1534 surveys were submitted. Bivariate and multivariate regression models were constructed to examine the associations between sociodemographic variables, depression, anxiety, and stress. The results demonstrated that the level …

2020-12-30_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-12-30_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Hospitals. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2020-12-30_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-12-30_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

Multifaceted Highly Targeted Sequential Multidrug Treatment Of Early Ambulatory High-Risk Sars-Cov-2 Infection (Covid-19), Peter A. Mccullough, Paul E. Alexander, Robin Armstrong, Cristian Arvinte, Alan F. Bain, Richard P. Bartlett, Robert L. Berkowitz, Andrew C. Berry, Thomas J. Borody, Joseph H. Brewer, Adam M. Brufsky, Teryn Clarke, Roland Derwand, Alieta Eck, John Eck, Richard A. Eisner, George C. Fareed, Angelina Farella, Silvia Ns Fonseca, Charles E. Geyer, Russell S. Gonnering, Karladine E. Graves, Kenneth Bv Gross, Sabine Hazan, Kristin S. Held, H. Thomas Hight, Stella Immanuel, Michael M. Jacobs, Joseph A. Ladapo, Lionel H. Lee, John Littell, Ivette Lozano, Harpal S. Mangat, Ben Marble, John E. Mckinnon, Lee D. Merritt, Jane M. Orient, Ramin Oskoui, Donald C. Pompan, Brian C. Procter, Chad Prodromos, Juliana Cepelowicz Rajter, Jean-Jacques Rajter, C. Venkata S. Ram, Salete S. Rios, Harvey A. Risch, Michael Ja Robb, Molly Rutherford, Martin Scholz, Marilyn M. Singleton, James A. Tumlin, Brian M. Tyson, Richard G. Urso, Kelly Victory, Elizabeth Lee Vliet, Craig M. Wax, Alexandre G. Wolkoff, Vicki Wooll, Vladimir Zelenko

Infectious Diseases Articles

The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, …

Integration Of Cardiovascular Risk Assessment With Covid-19 Using Artificial Intelligence., Jasjit S Suri, Anudeep Puvvula, Misha Majhail, Mainak Biswas, Ankush D Jamthikar, Luca Saba, Gavino Faa, Inder M Singh, Ronald Oberleitner, Monika Turk, Saurabh Srivastava, Paramjit S Chadha, Harman S Suri, Amer M Johri, Vijay Nambi, J Miguel Sanches, Narendra N Khanna, Klaudija Viskovic, Sophie Mavrogeni, John R Laird, Arindam Bit, Gyan Pareek, Martin Miner, Antonella Balestrieri, Petros P Sfikakis, George Tsoulfas, Athanasios Protogerou, Durga Prasanna Misra, Vikas Agarwal, George D Kitas, Raghu Kolluri, Jagjit Teji, Michele Porcu, Mustafa Al-Maini, Ann Agbakoba, Meyypan Sockalingam, Ajit Sexena, Andrew Nicolaides, Aditya Sharma, Vijay Rathore, Vijay Viswanathan, Subbaram Naidu, Deepak L Bhatt

Heart and Vascular Articles

Artificial Intelligence (AI), in general, refers to the machines (or computers) that mimic "cognitive" functions that we associate with our mind, such as "learning" and "solving problem". New biomarkers derived from medical imaging are being discovered and are then fused with non-imaging biomarkers (such as office, laboratory, physiological, genetic, epidemiological, and clinical-based biomarkers) in a big data framework, to develop AI systems. These systems can support risk prediction and monitoring. This perspective narrative shows the powerful methods of AI for tracking cardiovascular risks. We conclude that AI could potentially become an integral part of the COVID-19 disease management system. Countries, …

2020-12-29_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Hospitals. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

3-In-1 Hybrid Learning Environment, Holly Hapke, Anita Lee-Post, Tereza Dean

Marketing & Supply Chain Faculty Publications

We propose a learning innovation called 3-in-1 Hybrid environment as a solution for educational institutions to meet the challenge of balancing campus reopening against public health risks amid the COVID-19 pandemic. Our proposed innovation provides students options to attend class synchronously (either face-to-face or remote) or asynchronously (online) in an interactive learning environment that promotes emotional, behavioral, and cognitive engagement. We designed and implemented a large Marketing Management class with over 800 students as a 3-in-1 course. We examined its effectiveness in an empirical study and found that (1) students have a positive attitude toward 3-in-1 Hybrid learning; (2) they …

2020-12-29_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

Data is updated Monday through Saturday. Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Shipped, Distribution Trend, Doses Administered, Doses by Vaccine, Doses Metrics, Enrolled Providers, and …