Digital Commons Network^™

Early-Stage Corticostriatal Hyperactivity Impairs Cognitive Flexibility Alongside Striatal Cholinergic Dysfunction In An Alzheimer's Disease Model, Yufei Huang, Xueyi Xie, Zhenbo Huang, Ruifeng Chen, Himanshu Gangal, Xuehua Wang, Karienn Souza, Julia Hunter, Xin Wu, Doodipala Samba Reddy, Jeannie Chin, Jun Wang

Faculty, Staff and Students Publications

Cognitive flexibility declines early in Alzheimer's disease, yet the underlying circuit mechanisms remain unknown. Here, we report that young 5xFAD mice exhibit deficits in instrumental reversal learning prior to spatial memory impairment. This behavioral inflexibility is associated with abnormal neuronal reactivation in the medial prefrontal cortex and dorsomedial striatum. Electrophysiological recordings reveal that medial prefrontal cortex neurons are hyperexcitable and receive increased excitatory input. Furthermore, glutamatergic transmission from the medial prefrontal cortex to striatal direct-pathway medium spiny neurons is enhanced and coincides with strengthened inhibitory transmission onto striatal cholinergic interneurons, reduced spontaneous firing, and diminished striatal acetylcholine release. Critically, sustained …

Plasma Gdf15 Affects Long-Term Dementia Risk And Alters Neuroimmune Signaling, Cassandra O Blew, Michael R Duggan, Dimitrios Tsitsipatis, Gabriela T Gomez, Zulema Rodriguez-Hernandez, Luke C Pilling, Jingsha Chen, Eva Jacobsen, Heather E Dark, Yifei Lu, Shannon M Drouin, Cassandra M Joynes, Minhao Yao, Murat Bilgel, Abhay Moghekar, Qu Tian, Julián Candia, Mary Kaileh, Aditi Gupta, Krystyna Mazan-Mamczarz, Myriam Gorospe, Alexey Lyashkov, Yevgeniya Lukyanenko, Mika Kivimaki, Philipp Frank, Lori L Jennings, Valborg Gudmundsdottir, Vilmundur Gudnason, Lenore J Launer, Naoto Kaneko, Shintaro Kato, Makio Furuichi, Masaki Shibayama, Masahisa Katsuno, Keita Hiraga, Yukiko Nishita, Rei Otsuka, James R Pike, Mary R Rooney, Pascal Schlosser, Yuhan Cui, Guray Erus, Christos Davatzikos, Rebecca F Gottesman, Iwao Waga, Priya Palta, Christie Ballantyne, Michael Griswold, Zhonghua Liu, Luigi Ferrucci, Allison B Herman, Keenan A Walker

Faculty, Staff and Students Publications

Growth/differentiation factor-15 (GDF15) is a secreted cytokine strongly associated with dementia risk. However, the extent to which GDF15 represents a biomarker and driver of dementia risk remains unclear. Across multiple cohorts, we demonstrated that plasma GDF15 is associated with greater dementia risk over 15- to 25-year follow-up periods when measured in midlife, with stronger associations observed for vascular, compared to Alzheimer's disease (AD), dementia. Two-sample Mendelian randomization supported plasma GDF15's mechanistic role in AD and related dementias, while cohort studies linked it to cerebral small vessel disease, neurodegeneration, phosphorylated tau, and a cerebrospinal fluid proteomic signature indicative of neuroimmune activation. …

Demonstration Of 23-Gene Expression Profile Test Utility Within Prame Immunohistochemistry Results: A Case Series, Gregory A. Hosler, Matthew S. Goldberg, Etan Marks

GME Publications

Histopathological examination using hematoxylin and eosin (H&E)-stained tissue is sufficient for diagnosing most melanocytic neoplasms as benign or malignant; however, diagnostic tools such as PRAME (preferentially expressed antigen in melanoma) immunohistochemistry (IHC) and the 23-gene expression profile (23-GEP) test can aid in the analysis of histopathologically ambiguous lesions, which can be referred to as diagnostically challenging, equivocal, indeterminate, or uncertain. When compared with the gold standard of H&E diagnosis by a dermatopathologist, PRAME IHC showed 83.2% sensitivity and 99.3% specificity in an initial validation cohort and 23-GEP showed 91.5% sensitivity and 92.7% specificity in an independent validation cohort. In addition, …

Molecular Identification Of Cryptococcus Albidus Isolated From A Gingivitis Infection In A Male From Karbala City, Iraq, Maysaa Taqi Al-Khazali, Zahraa Raheem Murshidy, Sarah Kadhim Al-Rahimy, Sura Abd Ali Kadhim Mohammed, Dhuha Ali Hussein

Karbala International Journal of Modern Science

The current study presents a case of gingivitis caused by Cryptococcus albidus in a 35-year-old male from the city of Karbala in Iraq. This fungal species was identified via morphology, microscopy, additionally to the VITEK system. C. albidus was further confirmed using the polymerase chain reaction (PCR) technique by amplifying the 18S rRNA gene as a universal primer and sequencing. Sequences analysis revealed that this strain of C. albidus had not been previously documented in the NCBI database. Hence, the newly obtained sequences were submitted to the GenBank repository and assigned the accession number OQ975882.1, marking the first report of …

Association Of Executive Function And Resilience With Psychological Well-Being Among Early Adolescents: A Case Study In Northern Thailand, Kanyawee Teerawan, Monrudee Chokprajakchad, Jumpee Granger, Siriporn Nirapun

Journal of Health Research

Background: In early adolescence, psychological well-being represents an important developmental outcome. This period is marked by significant physical, emotional, and psychosocial transitions. Widely recognized as protective factors, executive function and resilience contribute to positive adolescent adjustment and mental health. However, investigations on the roles of these constructs among early adolescents in Northern Thailand in research remains limited.

Method: This study employed a cross-sectional correlational design, using secondary data from 210 lower secondary school students aged 11 to 13 years in Northern Thailand. Validated self-report questionnaires were used to collect data by assessing executive function, resilience, and psychological well-being. Direct associations …

Framing Tragedy: Discourse And Influence In Us Media Coverage Of The 1994 Rwanda Genocide, Andrew P. Young

Journal of 20th Century Media History

There is little doubt as to the mark left by the 1994 Rwandan genocide on historical discourse and perhaps even the American cultural consciousness. U.S. evening news broadcasts carried images of suffering and death into homes across the US, and in the process made Rwanda the site of one of the most recognized traumas in human history. While cultural proximity in mass media coverage played a role, the characterization of media coverage of the genocide, often defined in the press as explicit and constant, requires analysis. This project analyzes US evening network news broadcasts to address the actualities and implications …

Introducing Artificial Intelligence To The Metaverse, John O'Connor

Journal of Academic Research and Innovation

No abstract provided.

An Approach To Sacred Spaces From The Perspective Of The Connection Between Nature And Health, Ricard Fernàndez Molinet, Sílvia Gili Olmeda

International Religious Tourism and Pilgrimage Conferences

In a context marked by an increasing search for meaning and well-being, sanctuaries are re-emerging as significant spaces within contemporary spiritual tourism. This work proposes an approach to sanctuaries located in natural environments as liminal spaces, in the anthropological sense developed by Victor Turner, where processes of passage, transformation, and the reconfiguration of personal experience are facilitated. Historically, many sanctuaries have been established in places of strong symbolic and ecological significance, often linked to singular natural elements such as mountains, springs, forests, or caves which have been perceived as sites of connection with the numinous. These spaces have functioned not …

How Gyms Should Use Commitment Devices: The Role Of Deposit Contracts In Attracting Consumers, Zehua Hei, Alan Morse

Global Sport Business Journal

Amid growing health concerns, increased competition among fitness centers, and declining staff-to-customer ratios, gym operators are seeking effective ways to reduce customer attrition. Drawing on Prospect Theory, this study examines how commitment devices in gym promotions (e.g., deposit contracts and transformation challenges) influence consumers’ intentions to join a gym. Two experiments with 609 participants (Study 1 = 204; Study 2 = 405) investigated the mediating role of perceived attractiveness and the moderating role of contractual flexibility. Results indicate that membership options incorporating a commitment device were perceived as more attractive, leading to stronger registration intentions. However, this effect was observed …

The Shorthorn: October 29, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 26, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 27, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 22, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 20, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 21, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 19, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 14, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 13, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 12, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 7, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 8, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 6, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 5, 1982b

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 5, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: October 1, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: September 30, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: September 29, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: September 24, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: September 28, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: September 23, 1982

The Shorthorn Newspaper Collection: 1980s

No abstract provided.