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Colonic Epithelial Angiotensin-Converting Enzyme 2 (Ace2) Expression In Blacks And Whites: Potential Implications For Pathogenesis Covid-19 Racial Disparities, Mart De La Cruz, David P Nunes, Vaishali Bhardwaj, Deepika Subramanyan, Caroline Zaworski, Priya Roy, Hemant K Roy

Faculty, Staff and Students Publications

BACKGROUND: Covid-19 toll is disproportionate in Blacks although the mechanisms remain incompletely understood. From a biological perspective, several host proteins have received most attention as logical susceptibility targets. Specifically, angiotensin-converting enzyme 2 (ACE2) serves as the epithelial cell receptor and acts in concert with transmembrane protease serine 2 (TMPRSS2). Intriguingly, ACE2 can also suppress the inflammatory response and therefore may impact the severity of Covid-19 infections (from the exuberant immune response a.k.a. "cytokine storm"). We, therefore, assessed expression of ACE2 and TMPRSS2 in Blacks versus Whites.

METHODS: Archived mucosal biopsies from colonoscopic biopsies of visually normal rectal mucosa without concurrent …

Differences In Covid-19-Related Testing And Healthcare Utilization By Race And Ethnicity In The Veterans Health Administration, Javad Razjouyan, Drew A Helmer, Ang Li, Aanand D Naik, Christopher I Amos, Venkata Bandi, Amir Sharafkhaneh

Faculty, Staff and Students Publications

IMPORTANCE: Recent reports indicate differences in COVID-19-related care and outcomes between Black and White Americans.

OBJECTIVE: We examine the COVID-19-related healthcare utilization and mortality by race and ethnicity of patients tested for SARS-CoV-2 in the Veterans Health Administration (VHA).

DESIGN: A retrospective cohort study.

SETTING: We used the VHA COVID-19 shared data resources between February 1 and June 30, 2020.

PARTICIPANTS: Veterans tested for SARS-CoV-2 virus by VHA.

EXPOSURE(S): Three racial-ethnicity groups of Black, Hispanic, and White (as reference) veterans.

MAIN OUTCOME(S) AND MEASURE(S): Main outcomes are testing rate, positivity rate, hospitalization rate, ICU admission rate, and in-hospital mortality. Controlling …

Covid-19 And Telehealth Use Among Occupational Therapy, Physical Therapy, And Speech-Language Pathology Practitioners In The United States, Caesarinne Sprianu, Dragana Krpalek, Julie D. Kugel, Gurinder Bains, Lida Gharibvand

Internet Journal of Allied Health Sciences and Practice

Purpose: To explore occupational, physical, and speech-language pathology therapists’ perceived effectiveness of telehealth and how the COVID-19 pandemic has affected their professional roles. Method: Participants were recruited for the study through a research flyer distrusted via postal mail, emails, social media, and national association websites. An anonymous electronic 19-item survey was developed for this study by the researchers based on a review of the literature and clinical experience. Results. In total, 186 survey responses were obtained, with 152 meeting the inclusion criteria. The average age of participants was 38.6 years with an average work duration of 12.7 years ± 12.5 …

Development, Implementation, And Delivery Of A Remote Burnout Prevention Elective Course In An Accelerated Doctor Of Pharmacy Program During Covid-19, Melissa Santibanez, Jonathon May, Paul M. Boylan, Andrea Duque, Taylor Harris

Internet Journal of Allied Health Sciences and Practice

Purpose: There is limited evidence describing burnout among graduate health professions students, including pharmacy students, and there is a need for educational institutions to mitigate burnout and promote future healthcare provider wellness. Methods: A burnout prevention elective course was developed within an accelerated Doctor of Pharmacy program. Course faculty transitioned from live to fully remote instruction in April 2020. The modified course format combined discussion-based lectures, burnout self-assessments, reflective writing assignments, and applications-based presentations. Results: Twenty-one second-year pharmacy students completed the elective, and 13 completed post-course evaluations (61.9% response rate). Evaluations indicated substantial student support, with 92.3% “strongly agree” and …

The Therapeutic Value Of Reflective Writing During The Covid-19 Pandemic, Meagan Cleary, Kim O'Connor, Lynn Hennessy, Betty Mushynski, Susan Massatt, Nick Nowak

Nursing

No abstract provided.

Kidney Disease And Its Impact On Covid-19 Patients At Sanglah Hospital Denpasar, Bali, Indonesia In 2021, Putu Satyakumara Upadhana, I Gede Gita Sastrawan Sastrawan, I Gusti Agung Ayu Chintya Cahyarini, Anbiya Khairul Umam, Amanda Trisliana Dwi Putri, I Gede Raka Adhyatma, I Ketut Agus Somia

Jurnal Penyakit Dalam Indonesia

Introduction. Besides having an impact on the respiratory system, COVID-19 also has an impact on other organ such as the kidneys. The systemic inflammatory response thought to be associated with bad prognosis of COVID-19 patients with kidney disease. This study aimed to determine the impact of kidney disease on COVID-19 patients. Methods. This study is an observational analytic study with a cross-sectional approach. The data used is secondary data from the records of confirmed COVID-19 patients who were treated at Sanglah Hospital from 1 May 2021 to 31 August 2021 using total sampling technique.Results. There were 248 patients included in …

Abnormal Liver Function In Predicting Covid-19 Patients’ Prognosis, Sakinah Rahma Sari, Juferdy Kurniawan

Jurnal Penyakit Dalam Indonesia

Despite of the high prevalence of liver enzyme elevation in COVID-19 patients, its effect on predicting COVID-19 patients’ prognosis was still debatable. This evidence-based case report aims to evaluate the effect of abnormal liver function in the prognosis of COVID-19 patients. Literature searching was performed on August 16-17 2021 using 3 databases: PubMed, Scopus, and Proquest. The articles selected by title/abstract screening, duplication elimination, and applying eligibility criteria were then appraised using Centre of Evidence Based Medicine (CEBM), University of Oxford. Some of the studies reported there were no significant difference in the prognosis of COVID-19 patient with and without …

Efficient Targeted Transgenesis Of Large Donor Dna Into Multiple Mouse Genetic Backgrounds Using Bacteriophage Bxb1 Integrase., Benjamin E. Low, Vishnu Hosur, Simon Lesbirel, Michael V. Wiles

Faculty Research 2022

The development of mouse models of human disease and synthetic biology research by targeted transgenesis of large DNA constructs represent a significant genetic engineering hurdle. We developed an efficient, precise, single-copy integration of large transgenes directly into zygotes using multiple mouse genetic backgrounds. We used in vivo Bxb1 mediated recombinase-mediated cassette exchange (RMCE) with a transgene "landing pad" composed of dual heterologous Bxb1 attachment (att) sites in cis, within the Gt(ROSA)26Sor safe harbor locus. RMCE of donor was achieved by microinjection of vector DNA carrying cognate attachment sites flanking the donor transgene with Bxb1-integrase mRNA. This approach achieves perfect vector-free …

Pandemics And The Protection Of Privacy And Personal Information: Issues With Regard To The Use And Protection Of Information On The Basis Of Improving Public Health In The Fight Against Infectious Diseases, Fumio Shimpo

Japanese Society and Culture

In order to make use of the response to the new the coronavirus disease (COVID-19) for pandemic countermeasures due to infectious diseases that may have a serious impact on the lives and health of the people, which may occur in the future, the handling of personal information and the protection of privacy necessary to ensure the effectiveness of countermeasures against infectious diseases will be examined. This paper intends to establish to comprehensively understand the systems for the collection and publication of information related to infectious diseases based on the Infectious Diseases Control Law, and to clarify the structure and issues …

Leadership Matters: Supporting The Mental Health Needs Of Black And Latina/O Students In A Post Covid-19 World, Larry Walker, Michelle Sullivan, Nicola Stewart-Walker

Journal of Educational Leadership in Action

Communities throughout the United States were devastated by the COVID-19 virus. For instance, the mortality rates are higher within Black and Latina/o communities compared to the overall United States population. The pandemic represents another problem that will contribute to anxiety disorders and depression among Black and Latina/o students. How we combat these issues is important. During the 2020-2021 school year millions of students returned to schools and some struggled to adjust because of the traumatic experiences associated with COVID-19. Students will need the support of administrators, teachers, and mental health practitioners. For this reason, this review of literature examined the …

Consensus, Convergence, And Covid-19: The Ethical Role Of Religious Reasons In Leaders’ Response To Covid-19, Marilie Coetsee

Jepson School of Leadership Studies articles, book chapters and other publications

Focusing on current efforts to persuade the public to comply with COVID-19 best practices, this essay examines what role appeals to religious reasons should (or should not) play in leaders’ attempts to secure followers’ acceptance of group policies in contexts of religious and moral pluralism. While appeals to followers’ religious commitments can be helpful in promoting desirable public health outcomes, they also raise moral concerns when made in the contexts of secular institutions with religiously diverse participants. In these contexts, leaders who appeal to religious reasons as bases of justification for imposing COVID policies may seem to fail to show …

The Grizzly, March 31, 2022, Layla Halterman, Brooke Hurley, Amelia Kunko, Erin Corcoran, Marie Sykes, Ava Compagnoni, Liam Geib, Katie Cressman

Ursinus College Grizzly Newspaper, 1978 to Present

Mask On, Mask Off: New COVID Regulations • Changes to Disability Services • Honor Your Experience • Philanthropy Week Back Once More • Ursinus Word Search • Opinions: Squatting > Reimert Lottery; Spring Break: The Comeback Kid • The Bears Won't Stop Swinging • Track and Field CCC Recap

Future Anxiety And Immune Status In Nursing Students During The Coronavirus Disease-2019 Pandemic, Agus Purnama, Isti Anindya

Jurnal Keperawatan Indonesia

Coronavirus Disease-2019 (COVID-19) is a frightening global disease, especially because of its high contagiousness. This study aimed to identify the future anxiety regarding immunity status in nursing students who work in hospitals, especially those caring for patients with COVID-19. This study design was cross-sectional with standard translated instruments of the Future Anxiety Scale and Immune Status Questionnaire administered using a Google Form to 102 respondents. Results revealed that among the respondents, 87 experienced severe psychological anxiety (85.3%), 46 experienced moderate social anxiety (45.1%), 42 experienced moderate economic anxiety (41.2%), 38 experienced mild media anxiety (37.3%), 53 experienced mild religious anxiety …

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Mutation And Variant Of Coronavirus Disease 2019 (Covid-19): Review Of Current Literatures, Adityo Susilo, Chyntia Olivia Maurine Jasirwan, Syahidatul Wafa, Suzy Maria, Wulyo Rajabto, Akhmadu Muradi, Ihza Fachriza, Myranda Zahrah Putri, Stacy Gabriella

Jurnal Penyakit Dalam Indonesia

Since March 2020, the Coronavirus Disease 2019 (COVID-19) pandemic has engulfed the world, including Indonesia, for nearly two years. SARS-CoV-2 has undergone several mutations during its evolution as a pathogen, resulting in various variants of global concern. Variants of this virus are suspected to impede the outbreak resolution and possibly causing the outbreak to spiral out of control. There is still considerable debate and research underway regarding the new SARS-CoV-2 variants. Rapid transmission mechanisms and widespread vaccination coverage have accelerated the virus’s mutation rate and resulted in numerous new variants. To date, this has resulted in the discovery of a …

2022-03-30_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

2022-03-30 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Dlmm As A Lossless One-Shot Algorithm For Collaborative Multi-Site Distributed Linear Mixed Models, Chongliang Luo, Et Al

Open Access Publications

Linear mixed models are commonly used in healthcare-based association analyses for analyzing multi-site data with heterogeneous site-specific random effects. Due to regulations for protecting patients' privacy, sensitive individual patient data (IPD) typically cannot be shared across sites. We propose an algorithm for fitting distributed linear mixed models (DLMMs) without sharing IPD across sites. This algorithm achieves results identical to those achieved using pooled IPD from multiple sites (i.e., the same effect size and standard error estimates), hence demonstrating the lossless property. The algorithm requires each site to contribute minimal aggregated data in only one round of communication. We demonstrate the …

Impact Of Covid‐19 On Social Prescribing Across An Integrated Care System: A Researcher In Residence Study, Debra Westlake, Julian Elston, Alex Gude, Felix Gradinger, Kerryn Husk, Sheena Asthana

Peninsula Medical School

Emerging evidence suggests that connecting people to non-medical activities in the community (social prescribing) may relieve pressure on services by promoting autonomy and resilience, thereby improving well-being and self-management of health. This way of working has a long history in the voluntary and community sector but has only recently been widely funded by the National Health Service (NHS) in England and implemented in Primary Care Networks (PCNs). The COVID-19 global pandemic coincided with this new service. There is wide variation in how social prescribing is implemented and scant evidence comparing different delivery models. As embedded researchers within an Integrated Care …

Why Society Mistrusts The Science Of Covid-19, Calvin King

Undergraduate Honors Thesis Projects

In December of 2019 the first known case of Coronavirus Disease 2019 (COVID-19) was identified in Wuhan, China. One month later the virus had made its way to the United States and changed our daily lives forever. Mask mandates, social distancing, stay-at-home orders, and vaccinations have all been measures to help contain the spread of this deadly disease, but many people choose not to engage in these protocols not believing their effectiveness and mistrusting the science that went into making them. In this study a survey was administered to 98 participants online who were asked seven demographic questions and then …

Otolaryngology Subspecialty Surgical Rescheduling Rates During The Covid-19 Pandemic, Emily S Sagalow, Alexander Duffy, Priyanga Selvakumar, David Cognetti

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Objective: In the beginning of the COVID-19 pandemic in spring 2020, elective and oncologic surgical cases were cancelled. After adequate safety protocols were established, each subspecialty within otolaryngology faced unique challenges in reengaging patients for surgical scheduling.

Study design: Retrospective review from March to May 2020.

Setting: Single academic institution.

Methods: Patients whose otolaryngology surgery was cancelled due to COVID-19 hospital precautions were identified. Rescheduling rates were analyzed by subspecialty. Case completion was determined as the percentage of initially cancelled cases that were completed within 6 months of their original planned dates.

Results: Of 833 otolaryngology cases scheduled between March …

An In Silico Study Of The Cathepsin L Inhibitory Activity Of Bioactive Compounds In Stachytarpheta Jamaicensis As A Covid-19 Drug Therapy, Juliyatin Putri Utami, Nia Kurnianingsih, Mohammad Reza Faisal

Makara Journal of Science

Inhibition of cathepsin L (Cat L) can be considered a target for COVID-19 treatment. Starchytapheta jamaicensis is a plant from the Verbenaceae family that is commonly used for medicinal purposes. This study aims to analyze the inhibitory activities of compounds of Stachytarpheta jamaicensis toward Cat L by computational docking analysis. Ten compounds contained in the extracts (i.e., α-spinasterol, apigenin, luteolol-7-glucuronide, friedelin, hispidulin, chlorogenic acid, ipolamiide, geraniol, hentriacontane, and γ-aminobutyric acid) were selected as ligands; decanoyl-arg-val-lys-arg-chloromethylketone and oxocarbazate were used as the reference. Computational docking analysis was performed using Autodock Vina integrated into PyRx 8.0 and visualized using the Discovery Studio …

Moral Right To Healthcare And Covid-19 Challenges, Napoleon M. Mabaquiao Jr., Mark Anthony L. Dacela

Asia-Pacific Social Science Review

One fundamental healthcare issue brought to the fore by the current COVID-19 pandemic concerns the scope and nature of the right to healthcare. Given our increasing need for the usually limited healthcare resources, to what extent can we demand provision of these resources as a matter of right? One philosophical way of handling this issue is to clarify the nature of this right. Using the challenges of COVID-19 in the Philippines as the context of analysis, we argue for the view that regards the right to healthcare as fundamentally moral in kind, which should thereby guide its legal and contractual …

Age, Covid-19, And Mental Health In The Philippines: A Multidimensional Perspective, Hechanova Ma. Regina, Alvin Patrick Valentin, Karlos Pio Alampay

Asia-Pacific Social Science Review

The COVID-19 pandemic has caused many to become isolated, increased feelings of loneliness, and given rise to mental health issues. Using the Transactional Theory of Stress and Coping, this study looked at the predictors of mental health outcomes during the COVID-19 pandemic across age groups. Results showed that COVID-19 stressors, resilience, nonreactivity, and coping behaviors predicted stress, anxiety, depression, and psychological well-being. Cluster analysis revealed two age clusters—those between 16 and 35 years and those 36 years and above. The younger group reported greater depression, anxiety, and stress symptoms and poorer psychological well-being compared to the older group. The younger …

Intermediate Anticoagulation Dosing In Covid-19 Icu Patients: Evaluation Comparing Ventilated Vs Non-Ventilated Populations, Christopher Michael D'Amico

Applied Research Projects

Surges of COVID-19 have been seen to place large numbers of patients into the ICU. Establishing standards of care is critical not only for patient care, but to also implement a baseline of therapy to build upon with future research. COVID-19 produces a hypercoagulable state resulting in higher occurrences of clotting such as deep vein thrombosis (DVT), and pulmonary embolism (PE). Anticoagulation medications thin the blood to combat this aspect of the disease from occurring but does so at the risk of increasing bleeding potential. The purpose of this study is to evaluate the risk/benefit of anticoagulation usage between ventilated …

2022-03-29_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Extending Psychological Reactance Theory To Include Denial Of Threat And Media Sharing Intentions As Freedom Restoration Behavior, Noel H. Mcguire, Hannah Ball

Communication Faculty Articles and Research

This study extends psychological reactance theory by examining denial of a public health threat and resistance toward media sharing as two novel types of freedom restoration. Participants (N = 220) were randomly assigned to watch a video advocating COVID-19 guidelines and completed an online survey assessing corresponding perceptions and behavioral intentions. Results of structural equation modeling supported the two-step model of reactance: greater perceived freedom threat was related to greater reactance, which in turn was linked to lower intentions to comply with COVID-19 guidelines, lower intentions to share the video with one’s online social network, and greater denial of COVID-19 …

2022-03-28 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-03-28_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …