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The Computationally Designed Tri2-2 Miniprotein Inhibitor Protects Against Multiple Sars-Cov-2 Omicron Variants, Jimin Lee, James Brett Case, Young-Jun Park, Rashmi Ravichandran, Daniel Asarnow, M Alejandra Tortorici, Jack T Brown, Shilpa Sanapala, Lauren Carter, David Baker, Michael S Diamond, David Veesler

2020-Current year OA Pubs

The continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has compromised neutralizing antibody responses elicited by prior infection or vaccination and abolished the utility of most monoclonal antibody therapeutics. We previously described a computationally-designed, homotrimeric miniprotein inhibitor, designated TRI2-2, that protects mice against pre-Omicron SARS-CoV-2 variants. Here, we show that TRI2-2 exhibits broadly neutralizing activity of SARS-CoV-2 variants and protects mice against BQ.1.1, XBB.1.5 and BA.2.86 challenge when administered intranasally post-exposure. The resistance of TRI2-2 to viral escape by most variants and the ability to deliver it directly to the upper airways highlight the potential of the multivalent …

Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectivesThe chronic kidney disease (CKD) patients were at high risk for severe clinical complications during the COVID-19 pandemic. Our objectives were to evaluate comorbidity prevalence; predict mortality risks for CKD patients during the pandemic; assess how various health factors interact to influence mortality; and provide insights for targeted prevention strategies.MethodWe analysed data from 186,396 CKD patients in Mexico during the entire pandemic (Jan 2020- May 2023). Explainable artificial intelligence (XAI) methods with extreme gradient boosting (XGBoost) models and Shapley Additive Explanations (SHAP) were developed to predict mortality for CKD patients with model interpretations. Different metrics were used to comprehensively evaluate …

Covid-19 Infection And Hypertension In Correlation With Race, Elizabeth Durkin

The Pegasus Review: UCF Undergraduate Research Journal

Healthcare disparities exist in the U.S. between different races. This study investigated the frequency of COVID-19 infections and hypertension cases among five different racial groups (White, Black, Asian, Native American, and Native Hawaiian). The study also examined the correlation between COVID-19 infections and hypertension with the hypothesis that because of disease predisposition and socioeconomic barriers, Black populations would have the highest rates of COVID-19 infections and hypertension. We used data from the Kaiser Family Foundation regarding COVID-19 cases and race in conjunction with Census population data to determine whether COVID-19 case frequency means differed by race. Data on hypertension and …

Optimal Intervention Strategies In Age-Structured Sirvd Model: Epidemiological And Economic Analysis Of Covid-19 In Korea, Joon Chun, Melisa Hendrata

Spora: A Journal of Biomathematics

This study employed an age-structured Susceptible-Infected-Recovered-Vaccinated-Deceased (SIRVD) model to design optimal COVID‑19 intervention strategies by integrating epidemiological dynamics with economic costs. Using empirical data from South Korea, we estimated transmission parameters and analyzed quarantine-based non-pharmaceutical interventions (NPIs) alongside targeted vaccination scenarios. Our results indicated that a stronger form of mild NPI (upper range of Level I), when combined with targeted vaccination that prioritized seniors, achieved substantial reductions in infection peaks and overall economic burden. These findings underscore the effectiveness of age-specific strategies in epidemic management and offer critical insights for policymakers seeking balanced, resource-efficient approaches.

Examining First-Generation College Students’ Academic, Social, Emotional, And Financial Experiences During The Coronavirus 2019 (Covid-19) Pandemic, Anika Dorsey Good

Theses and Dissertations

This qualitative phenomenological study investigates the experiences of Black first-generation college students enrolled at a two-year college in the Northeast region of the United States during the COVID-19 pandemic. The study examines the narratives of a historically marginalized population in order to uncover the academic, social, and personal challenges they experienced due to the global health crisis. It also aims to explore the impacts, barriers, and resilience strategies of students through semi-structured interviews, reflective journal writing, and related artifacts. Research has shown that Black college students remain a historically underserved group enrolled in higher education. The Department of Education's National …

Anti-Sars-Cov-2 Nucleoprotein Iga Is Associated With Worse Disease Severity In Critically Ill Covid-19 Pneumonia Patients, David Brett-Major, Dylan S. George, Eric D. Morrell, Carmen Mikacenic, Julie Carstens, Laura E. Evans, Mark M. Wurfel, Pavan K. Bhatraju, M. Jana Broadhurst

Journal Articles: Epidemiology

While humoral responses to vaccination and infection have largely focused on IgG, there is an evolving literature on ways in which IgA may drive neutrophil activity in lung injury secondary to viral infections, including COVID-19. We evaluated 238 immune-naïve, critically ill patients in the first year of the COVID-19 pandemic. Employing a laboratory-developed, multiplexed antibody testing, clinical history, medical record, and machine learning, we pursued relationships between systemic IgA and disease severity. Individuals with elevated anti-N IgA had 4-fold odds of more severe disease. This work emphasizes the importance of continued work to understand how different elements of the immune …

Qualitative Exploration Of Covid-19 Vaccine Uptake Among Healthcare Workers In Sierra Leone: Do The ‘Trusted Messengers’ Trust The Vaccine?, Ifeolu David, Enid Schatz, Wilson Majee

Population Health Leadership and Analytics Faculty Publications and Presentations

Introduction

Vaccine hesitancy is a global issue, and the important role of healthcare workers in addressing vaccine hesitancy is well documented. However, there is limited theory-guided research on the uptake of COVID-19 vaccinations among healthcare workers in low- and middle-income countries (LMICs). This study examined COVID-19 vaccine uptake among healthcare workers in Sierra Leone and assessed the relevance of the 5C model—which posits that vaccine uptake is shaped by confidence, complacency, constraints, calculation and collective responsibility—in explaining their vaccination attitudes, intentions and behaviours.

Methods

24 indepth interviews were conducted in 2022 with healthcare workers in Freetown, Makeni and Kenema. The …

Chronic Absenteeism In Long Island Secondary Schools: A Mixed-Methods Study Of Post-Covid-19 Trends And Professional Perceptions, William M. Gibbons

Selected Full Text Dissertations, 2011-

Recent educational research studies have shown that an alarming number of students are chronically absent from school, a trend that is occurring both nationwide and in New York State. While this number had been slowly increasing before the COVID-19 pandemic, it has accelerated significantly following the pandemic. This increase in chronic absenteeism is also prevalent across Nassau and Suffolk County high schools; there has been a large increase in the percentage of students who are chronically absent in high school since the COVID-19 pandemic. Experts warn that this increased number can lead to multiple negative consequences for students, including social …

Trends Among Suspected Opioid Overdose Emergency Medical Service (Ems) Incidents In Georgia From 2019-2023, Ashton Harris

College of Graduate Studies: Theses & Dissertations

Opioid overdoses remain a problem in the United States, underscoring the need for additional surveillance tools to monitor trends in opioid overdoses. Emergency Medical Services (EMS) data is a timely surveillance method that captures more potential overdoses than hospitals by representing the pre-hospital setting. Research questions in the study assess EMS responses to suspect opioid overdose incidents from 2019-2023 in Georgia to encompass the following characteristics: timeframe (pre, during, post-pandemic), urban versus rural counties, race/ethnicity, categorical type of first responder, mean dosage of naloxone in milligrams administered, and death. 84,359 records meeting the inclusion criteria were initially retrieved from the …

Arrhythmogenic Covid-19 Myocarditis Presenting As Out-Of-Hospital Ventricular Fibrillation Arrest With Preserved Ejection Fraction, Mohamed Ahmed, Elinor Barsh, Dmitriy Scherbak

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

Viral Misunderstandings: Reddit Posts And The Covid-19 Infodemic, Julia C. Knutson

Scripps Senior Theses

Information epidemics or “infodemics” became the center of misinformation conversations, due to a global increase in information spread surrounding the COVID-19 pandemic. While many academic scholars and institutions, such as the World Health Organization (WHO) attribute the cause of infodemics to anti-science attitudes and the public’s lack of scientific literacy, scholars in Science, Technology, and Society argue that analyzing misinformation within these isolated bounds limits our understanding of its underlying social and historical contexts. Using the COVID-19 pandemic as a case study for misinformation analysis reveals a gap in our current understanding of how people who resonate with or spread …

Facebooking Under Crisis: A Comparative Study Of Online French And American Mutual Aid Organizing During The Covid-19 Pandemic, Clare Reimers-Hejnal

Scripps Senior Theses

This thesis studies the political discussions, practices, and projects that emerged through mutual aid Facebook groups based in France and the United States during the COVID-19 pandemic. Of particular interest is how these online spaces and the Facebook users that comprised them understood their mutual aid organizing in relationship to specific themes, including but not limited to: the COVID-19 pandemic as a "crisis", the role of government presence or absence in the wellbeing of the public, and the concept of collective yet differentiated struggle. Chapter 1 looks at four Facebook pages based in the greater Paris area: Entraide Danube, Clichy …

Evaluation Of Interventions For Cognitive Symptoms In Long Covid: A Randomized Clinical Trial, David S Knopman, Deborah Koltai, Daniel T Laskowitz, Jacqueline Becker, Leigh Charvet, Juan Wisnivesky, Alex Federman, Adam Silverstein, Yuliya Lokhnygina, Giuseppina Pilloni, Michelle Haddad, Henry Mahncke, Tom Van Vleet, Rong Huang, Wendy Cox, Diana Terry, Jeannie Karwowski, Netia Mccray, Jenny J Lin, Grace A Mccomsey, Upinder Singh, Linda N Geng, Helen Y Chu, Rebecca Reece, James Moy, Zoe Arvanitakis, Sairam Parthasarathy, Thomas F Patterson, Aditi Gupta, Luis Ostrosky-Zeichner, Jeffrey Parsonnet, Elaine T Kiriakopoulos, Tamara G Fong, Janet Mullington, Sarah Jolley, Nirav S Shah, Sarah Shizuko Morimoto, Joyce K Lee-Iannotti, William D S Killgore, Brigid Dwyer, William Stringer, Carmen Isache, Jennifer A Frontera, Jerry A Krishnan, Ashley O'Steen, Melissa James, Barrie L Harper, Kanecia O Zimmerman

Faculty, Staff and Student Publications

Importance: Treatment for cognitive dysfunction due to postacute sequelae of long COVID (ie, symptoms of fatigue, malaise, weakness, confusion that persist beyond 12 weeks after an initial COVID infection) remains a significant unmet need.

Objective: To test evidence-based rehabilitation strategies for improving cognitive symptoms in persons with long COVID.

Design, setting, and participants: This was a 5-arm, multicenter, randomized clinical trial of 3 remotely delivered interventions conducted between August 17, 2023, and June 10, 2024. The study took place at 22 trial sites and included the screening of individuals with cognitive long COVID.

Interventions: Participants were randomized to 1 of …

The Placenta & Covid-19: Histological Changes & Clinical Implications, Melissa F. Paul, Allyson J. Zadlo Sensor

All Electronic Theses and Dissertations

Introduction: The COVID-19 pandemic presented the medical community with complex and novel challenges, not the least of which is how to optimize prenatal and postnatal care for pregnant individuals who have been infected. At present, seven years have elapsed, and despite definitive research demonstrating adverse outcomes associated with placental changes, no professional consensus has been reached.
Methods: This integrative review includes studies involving pregnant individuals with confirmed SARS-CoV-2 infection, who recovered during the same pregnancy, and their infants. An examination of the data available reveals a triad of placental pathologies (chronic histiocytic intervillositis, perivillous fibrin deposition, and trophoblast necrosis) that …

“We’Re All In The Struggle Together”: The Experiences Of First-Generation Graduate Students During Covid-19, Rebecca Stallworth, Danielle E. Maurici-Pollock, Jade Obler, Rachel A. Starr

Publications

This study explores the experiences of first-generation graduate students (FGGS) during the COVID-19 pandemic, specifically the positive and negative impacts of the pandemic on their learning experiences and their implications for the design of online graduate programs that foster a sense of belonging.

Bayesian Reanalysis Of Early Remdesivir For The Treatment Of Covid-19 In Outpatients With High Risk Of Progression To Severe Disease, Mazin Abdelghany, Fang Yu, Stephen I. Rennard, Yeongjin Gwon

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Though Bayesian methods are flexible, intuitive, and readily incorporated into clinical decision-making, with particular utility when prior information is available, they remain underutilized in the analysis of clinical trials.

METHODS: In PINETREE, a Phase 3 randomized controlled trial (RCT) of remdesivir (RDV) for the treatment of outpatients with COVID-19 at high risk of severe disease, the primary outcome of COVID-19-related hospitalization or all-cause death was reanalyzed using a range of reference and data-driven priors. Posterior probability distributions were used to calculate the probability that the estimated hazard ratio (HR) was below a range of clinically meaningful specified thresholds and …

Institutional Retention And Graduation Outcomes Before And During Covid-19: A Comparison Of Online-Experienced And Online-Inexperienced Four-Year Institutions, Nicholas J. Finnessey

Theses and Dissertations

This study examined whether student success outcomes and their trajectories over time differed across higher education institutions before, during, and after the COVID-19 pandemic based on prior experience with online education. Guided by Astin’s (1993) Input-Environment-Output (I-E-O) framework, pre-pandemic participation in online coursework was conceptualized as an institutional-level environmental condition. A quantitative, causal-comparative research design was employed, using secondary data from the Integrated Postsecondary Education Data System (IPEDS), to examine longitudinal differences in institutional retention and graduation rates across institutions classified by their pre-pandemic participation in online education. The sample included 528 Title IV-eligible, degree-granting, four-year institutions observed across five …

Wastewater Surveillance For Sars-Cov-2 In Rural Kentucky, 2021–2023, James W. Keck, Reuben Adatorwovor, Ann Noble, Savannah Tucker, William Strike, Soroosh Torabi, Mohammad Dehghan Banadaki, Blazan Mijatovic, Steven K. Roggenkamp, Donna Mcneil, Lindell Ormsbee, Scott M. Berry

Family and Community Medicine Faculty Publications

Wastewater testing for SARS-CoV-2 provided useful public health information during the COVID-19 pandemic yet was underutilized in rural communities. We addressed this gap by implementing wastewater surveillance and assessing its performance in 10 communities in Eastern Kentucky. We collected wastewater samples 1–2 times weekly at 10 wastewater treatment plants (WWTPs) from May 2021 until April 2023 and measured SARS-CoV-2 RNA concentrations using polymerase chain reaction testing. We calculated time-lagged correlations between wastewater concentrations and county-level reported COVID-19 cases by site. We developed a generalized linear model to estimate COVID-19 incidence from wastewater SARS-CoV-2 concentrations. The 10 participating WWTPs served 2430 …

An Unusual Case Of Genetic Dilated Cardiomyopathy Unmasked By Covid-19 Infection, Greeshma Molugu, Daniel Mcmahan, Seline Haci, Giridhar Mundluru, Machaiah Madhrira

North Texas GME Research Forum 2026

Introduction: Titin (TTN) mutations are a well-known cause of dilated cardiomyopathy (DCM), occurring in approximately 25% of familial cases of idiopathic DCM and 18% of sporadic cases. Recognition and referral for genetic testing remains underutilized but has important prognostication and helps the patient better understand the disease transmission. This case report stresses the importance of a complete evaluation for genetic causes of DCM.

Case Presentation: A 21-year-old male who was adopted as an infant was hospitalized with COVID-19 infection and diagnosed with non-ischemic cardiomyopathy with an initial left ventricular ejection fraction (EF) of 10%. He was assumed to have DCM …

Understanding Addiction As A Disease: College Students’ Perspectives On Substance Use In The Covid-19 Era, Aditi Rudrashetty

Athena: Undergraduate Research and Literary Journal

This research explores the neurological basis of addiction as a disease and how the exacerbation of external factors has contributed to negative perceptions of addiction. Specifically, it examines the COVID-19 pandemic and contemporary college student experiences as contextual factors influencing attitudes toward substance use disorders. Negative perceptions contribute to stigma, reduce help-seeking behavior, and influence policy responses, hindering effective support and recovery for individuals with substance use disorders. By examining these perceptions, this study contributes to understanding how addiction is conceptualized and potentially addressed in public health and policy contexts. Surveys and semi-structured interviews were conducted with college students to …

Exploring The Use Of Strategic Influencer Leadership (Sil) In Health Communication: A Cross-Cultural, Multi-Case Study, Katharina Wolf, Catherine Archer, Syafiq B. Assegaff, Joseph Nalloor

Research outputs 2022 to 2026

Purpose This study challenges the social media-centric view of influencers, arguing that health communication benefits from diverse strategic influencers beyond commercial figures. Trust, credibility and cultural resonance are essential for effective public health messaging, yet contemporary approaches often prioritise engagement metrics over strategic influence. Design/methodology/approach This paper employs a multi-case study approach to examine the strategic use of influencers in health communication across Indonesia, the United Arab Emirates and Australia during the COVID-19 pandemic. It explores how health professionals, royal representatives and a politician shaped public health messaging within culturally specific contexts. A mixed-methods approach, incorporating ethnographic research and thematic …

Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales

Graduate Theses/Dissertations

COVID‑19 demonstrated how a single biological event can strain health systems, disrupt supply chains, undermine national security, and erode public trust. This shock occurred as biotechnology became dramatically more accessible: gene editing and synthetic biology tools once limited to specialized laboratories are now widely available through inexpensive equipment, open‑source data, and decentralized expertise.

This expanded access accelerates innovation but also broadens the threat landscape. The ability to reconstruct pathogens using publicly available sequences and mail‑order DNA shows that complex biological synthesis is no longer confined to state programs. These risks are amplified by opaque biotechnology activities in China, Russia, and …

The Differential Impacts Of Internal And External Corporate Social Responsibility Activities On Consumer Trust After Covid-19, Kennadi C. Mccoy

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the strategic role of Corporate Social Responsibility (CSR) in helping small businesses recover from crises, with a specific focus on the COVID-19 pandemic. Different from many traditional studies that highlight the ethical or reputational aspects of CSR, this research will examine its practical effects: how CSR initiatives during crises influence business success by enhancing consumer trust, particularly by examining the differential impact of Internal CSR versus External CSR. The study suggests that, compared with internally focused CSR, external CSR activities will have a greater impact on consumer trust. In addition, the dissertation suggests that this effect is …

If I Only Had The Words (To Tell You): Billy Joel Lyrics In Legal And Medical Scholarship, Seuli Bose Brill, Christian H. Brill

Touro Law Review

Law and medicine are often considered to be among the least accessible professions, partly because of the heavy use of non colloquial jargon. This article examines more than 150 instances in which Billy Joel’s lyrics have been used to improve the accessibility of legal and medical scholarship. Legal and medical professionals have used the words of the “Piano Man” to discuss a variety of topics—everything from civil procedure to property rights and the COVID-19 pandemic to colorectal surgery. Nontraditional communications techniques of this type do not just contribute to the body of legal and medical scholarship; they also help professionals …

The Covid-19 Pandemic: Predictors Of Inpatient Admission For People With Severe Mental Illnesses, Ashley Killoren

PCOM Psychology Dissertations

The purpose of the study was to identify differences in patterns of demographic and psychiatric symptoms among individuals with severe mental illnesses admitted to an inpatient psychiatric hospital 1 year before the quarantine shelter-in-place restriction order issued by a governor in the Northeastern United States, during the restriction order, and 1 year starting when all COVID-19 restrictions were lifted. A second goal of the study was to determine whether psychiatric admission rates changed by comparing admission rates before and during the quarantine order, and 1 year after all COVID-19 restrictions were lifted. This quantitative, retrospective, observational study was achieved by …

Mortality From Or With Covid-19 Infection, Dagan Coppock, Joseph Glowacki, Constantine Daskalakis, John Zurlo, Nikita Jaggernauth, Daniel Taupin

Division of Infectious Diseases and Environmental Medicine Faculty Papers

In this retrospective study, we compared the cause of death among hospitalized patients who died with a diagnosis of COVID-19 across two periods of the pandemic two years apart: an early period (admissions June to October 2020), when the population was immunologically naïve, and a later period (admissions April to October 2022), when an estimated 96% of the population had immunity from prior infection, vaccination, or both. Two investigators independently reviewed the medical records of 100 in-hospital deaths (50 per period) and classified each death as COVID-19 related, uncertain, or not COVID-19 related, using logistic regression to compare the two …

Mental Health Needs Of Families Of Patients In Intensive Care Units And The Role Of Mobile Health: Survey Study, Anthony Faiola, Saira Soroya, Zhonglin Hao, Reinhold Munker

Markey Cancer Center Faculty Publications

Background: The experiences of patients with COVID-19 and their families manifested the most devastating effects of family separation since the 1918 Spanish influenza pandemic and, with it, a call for solutions to patient isolation and its effect on family mental health.

Objective: This study examined the recent experiences of families of critical care (intensive care unit; ICU) patients related to anxiety and depression (AD), satisfaction with clinician-family communication, and counseling from mental health and social services. This study explored correlations between these factors and family interest in mobile health (mHealth) designed to improve information flow and communication from patient bedside …

Prognostic Value Of Lung Injury Biomarkers In Patients Hospitalized With Covid-19 Without Respiratory Failure At Admission, Jennifer G. Wilson, Greg A. Grandits, Birgit Grund, Shweta S. Mistry, Carolyn Leroux, Angelika Ringor, Neil R. Aggarwal, Daniel D. Murray, Christina E. Barkauskas, Samuel M. Brown, Elizabeth Higgs, Kathryn Shaw-Saliba, Adam Rupert, Virginia L. Kan, Jeremy R. Beitler, Omar Awan, Jamie L. Sturgill, Halima Dawood, Andre C. Kalil, Ioannis Kalomenidis, Abhijit Duggal, Sarah C. Sasson, Minh Q. Ho, Hien H. Nguyen, Jens D. Lundgren, Adit A. Ginde, Wesley H. Self, H. Clifford Lane, Michael A. Matthay, Angela J. Rogers

Markey Cancer Center Faculty Publications

Objectives: – The COVID-19 pandemic highlighted an urgent need to more efficiently identify patients at highest risk for developing respiratory failure. We investigated whether plasma levels of lung injury biomarkers are associated with progression to respiratory failure among adults hospitalized with COVID-19 pneumonia without respiratory failure at admission. Design: – This was a nested case-control study of COVID-19 patients enrolled in the Accelerating COVID-19 Therapeutic Interventions and Vaccines-3 (ACTIV-3)/Therapeutics for Inpatients with COVID-19 (TICO) platform trial who were on less than 20 L/min supplemental oxygen at enrollment. We compared baseline measurements of lung injury biomarkers between participants who progressed to …

Beyond The Pandemic: How Covid-19 Highlighted The Need For Cross-Sector Healthcare Solutions For Young Australians Living With Adversity, Ennur Erbasi, Shannon Muir, Karen Mclean

Research outputs 2022 to 2026

We explored the perceived impacts of the COVID-19 pandemic on health and healthcare access among young people living with significant adversity in Victoria, Australia, using a convergent parallel mixed-methods design. Guided by a pragmatism epistemology, fifty-seven purposively sampled Victorian adolescents aged 15–19 years with lived experience of adversity completed a primarily quantitative online survey, and eight also participated in semi-structured interviews. Descriptive quantitative results indicated that a greater proportion of participants rated their mental health as fair or poor during COVID-19 (69%) compared to before the pandemic (40%). Similarly, more participants rated their physical health as fair or poor during …

Impact Of Covid-19 Infection On Left Ventricular Systolic And Diastolic Functions., Hazem Galal Mohamed, Maged Zaghloul Mohamed Amer, Aml Fathy Moustafa, Shady Hussein Mohamed

Mansoura Medical Journal

Background: SARS-CoV-2, the pathogen behind COVID-19, often involves the cardiovascular system due to high ACE2 receptor density in myocardial tissue. While immediate cardiac complications are recognized, the persistent effects on left ventricular (LV) performance require further investigation through echocardiography.

Aim: This study aimed to comprehensively describe the sequelae of COVID-19 infection on the left ventricle using echocardiography

Methods: The study included 100 participants. Cardiac function was assessed using a standard 12-lead ECG and transthoracic echocardiography. LV systolic function was evaluated using the Biplane Simpson Method, and myocardial contractility was further analyzed using Speckle-Tracking Echocardiography (STE).

Results: The mean age was …