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COVID-19

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A Multiomics Recovery Factor Predicts Long Covid In The Impacc Study, Gisela Gabernet, Jessica Maciuch, Jeremy P Gygi, John F Moore, Annmarie Hoch, Caitlin Syphurs, Tianyi Chu, Naresh Doni Jayavelu, David B Corry, Farrah Kheradmand, Lindsey R Baden, Rafick-Pierre Sekaly, Grace A Mccomsey, Elias K Haddad, Charles B Cairns, Nadine Rouphael, Ana Fernandez-Sesma, Viviana Simon, Jordan P Metcalf, Nelson I Agudelo Higuita, Catherine L Hough, William B Messer, Mark M Davis, Kari C Nadeau, Bali Pulendran, Monica Kraft, Chris Bime, Elaine F Reed, Joanna Schaenman, David J Erle, Carolyn S Calfee, Mark A Atkinson, Scott C Brakenridge, Esther Melamed, Albert C Shaw, David A Hafler, Alison D Augustine, Patrice M Becker, Al Ozonoff, Steven E Bosinger, Walter Eckalbar, Holden T Maecker, Seunghee Kim-Schulze, Hanno Steen, Florian Krammer, Kerstin Westendorf, Bjoern Peters, Slim Fourati, Matthew C Altman, Ofer Levy, Kinga K Smolen, Ruth R Montgomery, Joann Diray-Arce, Steven H Kleinstein, Leying Guan, Lauren Ir Ehrlich Nov 2025

A Multiomics Recovery Factor Predicts Long Covid In The Impacc Study, Gisela Gabernet, Jessica Maciuch, Jeremy P Gygi, John F Moore, Annmarie Hoch, Caitlin Syphurs, Tianyi Chu, Naresh Doni Jayavelu, David B Corry, Farrah Kheradmand, Lindsey R Baden, Rafick-Pierre Sekaly, Grace A Mccomsey, Elias K Haddad, Charles B Cairns, Nadine Rouphael, Ana Fernandez-Sesma, Viviana Simon, Jordan P Metcalf, Nelson I Agudelo Higuita, Catherine L Hough, William B Messer, Mark M Davis, Kari C Nadeau, Bali Pulendran, Monica Kraft, Chris Bime, Elaine F Reed, Joanna Schaenman, David J Erle, Carolyn S Calfee, Mark A Atkinson, Scott C Brakenridge, Esther Melamed, Albert C Shaw, David A Hafler, Alison D Augustine, Patrice M Becker, Al Ozonoff, Steven E Bosinger, Walter Eckalbar, Holden T Maecker, Seunghee Kim-Schulze, Hanno Steen, Florian Krammer, Kerstin Westendorf, Bjoern Peters, Slim Fourati, Matthew C Altman, Ofer Levy, Kinga K Smolen, Ruth R Montgomery, Joann Diray-Arce, Steven H Kleinstein, Leying Guan, Lauren Ir Ehrlich

Faculty, Staff and Students Publications

Background: Following SARS-CoV-2 infection, approximately 10%–35% of patients with COVID-19 experience long COVID (LC), in which debilitating symptoms persist for at least 3 months. Elucidating the biologic underpinnings of LC could identify therapeutic opportunities.

Methods: We utilized machine learning methods on biologic analytes provided over 12 months after hospital discharge from more than 500 patients with COVID-19 in the IMPACC cohort to identify a multiomics “recovery factor,” trained on patient-reported physical function survey scores. Immune profiling data included PBMC transcriptomics, serum O-link and plasma proteomics, plasma metabolomics, and blood mass cytometry by time of flight (CyTOF) protein levels. Recovery factor …


University Students’ Condom Use During The Covid-19 Pandemic: Cross-Cultural Differences And What Predict Them, Liam Dacosta, James S. Morandini, Rebecca T. Pinkus, Elien De Caluwé, Lik Sam Chan, Olivine Lo, Saowanee Thongnopakun, Sawitree Visanuyothin, Cheryl Harasymchuk, Samantha Joel, Helen C. Harton, Alyssa Mccoy, Victoria Dale, David L. Rodrigues, Judit Takács, Alexandra Sipos, Veronica M. Lamarche, Racidon Bernarte, Viktorija Čepukienė, Ivana M. Jakšić, Bojana Bodroža, Huỳnh Hồng Mai, Tran Thi Hong, Grace Akello, Ivana Hromatko, Asha Ganesan, Jiawei Zhang, Damian Murray, James Moran, Juan Ramón Barrada, Ángel Castro, Claudia Navarro-Roldan, Kuan-Pin Su, Jane Chang, Matthew B. Ruby, Donya Ziadlou, Shin Nakamine, Yutaka Watanabe, Albert Lee, Richelle-Joy Chia, Ilan Dar-Nimrod Oct 2025

University Students’ Condom Use During The Covid-19 Pandemic: Cross-Cultural Differences And What Predict Them, Liam Dacosta, James S. Morandini, Rebecca T. Pinkus, Elien De Caluwé, Lik Sam Chan, Olivine Lo, Saowanee Thongnopakun, Sawitree Visanuyothin, Cheryl Harasymchuk, Samantha Joel, Helen C. Harton, Alyssa Mccoy, Victoria Dale, David L. Rodrigues, Judit Takács, Alexandra Sipos, Veronica M. Lamarche, Racidon Bernarte, Viktorija Čepukienė, Ivana M. Jakšić, Bojana Bodroža, Huỳnh Hồng Mai, Tran Thi Hong, Grace Akello, Ivana Hromatko, Asha Ganesan, Jiawei Zhang, Damian Murray, James Moran, Juan Ramón Barrada, Ángel Castro, Claudia Navarro-Roldan, Kuan-Pin Su, Jane Chang, Matthew B. Ruby, Donya Ziadlou, Shin Nakamine, Yutaka Watanabe, Albert Lee, Richelle-Joy Chia, Ilan Dar-Nimrod

Faculty Publications

Humans instinctively adopt methods to reduce their risk of encountering harmful pathogens, yet their adherence to preventive health practices can often be erratic. Condoms exemplify one vital preventive tool against sexually transmitted infections (STIs) that, despite their effectiveness, are not consistently utilized. This pattern of behavior appears to persist even during periods of widespread disease transmission, with varied data from the COVID-19 pandemic indicating that condom usage remained inconsistent. The present study aimed to clarify these inconsistencies by examining changes in condom use cross-culturally. Heterosexual participants who were sexually active (N = 3,972 [1,327 men, 2,645 women], Mage= 22.82) across …


Trajectory Of Tinnitus Distress Across The Covid-19 Pandemic: A Cross-Sectional Analysis Of Self-Reported Symptoms, Anusha Yellamsetty, Mika Shin Oct 2025

Trajectory Of Tinnitus Distress Across The Covid-19 Pandemic: A Cross-Sectional Analysis Of Self-Reported Symptoms, Anusha Yellamsetty, Mika Shin

Faculty Research, Scholarly, and Creative Activity

Purpose: This study aimed to evaluate retrospectively self-reported changes in tinnitus severity and distress associated with the COVID-19 pandemic and vaccination using validated self-report instruments. It further explored patient-reported onset of tinnitus following vaccination, gender differences in symptom severity, and associations with psychological distress. Method: A cross-sectional online survey was completed by 189 adults between December 2023 and April 2024. Participants retrospectively self-reported tinnitus onset and severity before, during, and after the COVID-19 pandemic using the Tinnitus Handicap Inventory (THI) and the Tinnitus Reaction Questionnaire (TRQ). Additional items assessed COVID-19 vaccination history, infection status, and adverse vaccine reactions. Repeated measures …


Religious Festivals In The Age Of ‘Lockdown’ And ‘Social Distancing’: A Comparative Study Of Easter, Eid, Passover, Rama Navami, And Vaisakhi., Irfan Raja, Rev. Ruth Dowson, Abdul Basit Shaikh, Ivan Cohen, Nasser N. Alotaibi Oct 2025

Religious Festivals In The Age Of ‘Lockdown’ And ‘Social Distancing’: A Comparative Study Of Easter, Eid, Passover, Rama Navami, And Vaisakhi., Irfan Raja, Rev. Ruth Dowson, Abdul Basit Shaikh, Ivan Cohen, Nasser N. Alotaibi

International Journal of Religious Tourism and Pilgrimage

Religious practices can conjure distinctive ideas and images for different groups of people, especially religious festivals, which are signs of congregations, celebrations, and contentment, usually to mark the completion of religious obligations. All major religions celebrate notable festivals to mark important events and religious obligations that bring together followers of that faith. The year 2020 will be remembered as unique in the history of all faiths. As a result of the COVID-19 crisis, governments across the world announced compulsory measures such as ‘social distancing’ and ‘lockdown’ to avoid the spread of Coronavirus. Thus, all major religions either cancelled or reduced …


Multilateral Organizations And Health Emergency Management During Crisis: The Case Study Of The World Health Organization During Covid-19 Pandemic, Aya Helmy Hamada Oct 2025

Multilateral Organizations And Health Emergency Management During Crisis: The Case Study Of The World Health Organization During Covid-19 Pandemic, Aya Helmy Hamada

Theses and Dissertations

Multilateral organizations, such as the World Health Organization (WHO), play a key role in managing health emergencies during crises. During the COVID-19 pandemic, WHO achieved significant progress by supporting countries with technical assistance, guidelines, and essential resources. As well as providing technical guidance, sharing information, and coordinating among member states. This experience highlighted the importance of WHO in tackling global public health problems and showed how multilateral collaboration can help address complex challenges. Moreover, risk and crisis communication proved to be a critical part of WHO’s response, ensuring that clear and timely information reached the public and stakeholders. Despite these …


Violence Of Husbands Against Reproductive Age Wives During Covid-19 Pandemic, Zainab Aljoori, Mushtaq Hashim Oct 2025

Violence Of Husbands Against Reproductive Age Wives During Covid-19 Pandemic, Zainab Aljoori, Mushtaq Hashim

Iraqi Postgraduate Medical Journal

Background:The COVID-19 pandemic has led to a surge in domestic violence, affecting women's physical and mental health through direct and indirect means. A history of violence can increase the risk of various diseases, and severe abuse can persist even after the violence ceases.MethodsA cross-sectional web-based survey that included 500 women calculated according to Roasoft calculator based on previously published Iraqi studies , it was convenience sampling and was conducted between June and September among 15-49 year old Iraqi women, recruited via social media platforms, and completed until a sample size of 500 forms was collected.ResultsThe study found that psychological violence …


Hap-Covid: Hybrid Model Integrating Machine Learning And Neutrosophic Statistics To Estimate Mortality Risk In Covid-19 Comorbid Patients, Daniel Iturburu-Salvador, Lorenzo Cevallos-Torres, Rosangela Caicedo-Quiroz, Irma Naranjo-Peña, Rosa Hernández-Magallanes, Rosa Gonzáles-Quiñones Oct 2025

Hap-Covid: Hybrid Model Integrating Machine Learning And Neutrosophic Statistics To Estimate Mortality Risk In Covid-19 Comorbid Patients, Daniel Iturburu-Salvador, Lorenzo Cevallos-Torres, Rosangela Caicedo-Quiroz, Irma Naranjo-Peña, Rosa Hernández-Magallanes, Rosa Gonzáles-Quiñones

Neutrosophic Sets and Systems

This study aims to utilize a hybrid predictive model to evaluate the mortality risk in COVID-19 patients with comorbidities. It is challenging to make clinical decisions while dealing with SARS-CoV-2 because of the high death rate related to chronic conditions such as diabetes, hypertension, chronic obstructive pulmonary disease (COPD), renal failure, heart disease, and cancer. To overcome this obstacle, a Monte Carlo algorithm-based simulated database was created, with clinical variables represented by Bernoulli and truncated normal distributions. Several prediction models, including Decision Trees, Naive Bayes, and Neutrosophic Statistics, were trained using this database. While the neutrosophic model permitted risk categorization …


Covid's Impact On Our Youngest Learners, Scottie Ellsworth Sep 2025

Covid's Impact On Our Youngest Learners, Scottie Ellsworth

Journal of the Symposium of University Research and Creative Expression

Project Mentor(s): Amanda Obery, PhD; Wendie Castillo

The COVID-19 pandemic profoundly disrupted education, leaving lasting effects on elementary students’ academic development, particularly in literacy and reading comprehension. This research investigated the long-term educational impacts of the pandemic by drawing on qualitative insights from interviews with five educators across a range of specializations, including general education, interventional support, and multilingual learning. Using inductive thematic analysis and descriptive coding, the study identified key themes that reflected shifts in academic achievement, student behavior, attendance, and school priorities post-pandemic. These findings illuminate critical areas where students require support and outline the structural, instructional, and …


Whole-Blood Cellular Responses: A Promising Indicator Of Sars-Cov-2 Immunity Compared To Serology, Lucas M. Zhou, Elizabeth H. Duncan, Rupsa C. Boelig, Margaret Costanzo, Jeffrey R. Currier, Elke S. Bergmann-Leitner Sep 2025

Whole-Blood Cellular Responses: A Promising Indicator Of Sars-Cov-2 Immunity Compared To Serology, Lucas M. Zhou, Elizabeth H. Duncan, Rupsa C. Boelig, Margaret Costanzo, Jeffrey R. Currier, Elke S. Bergmann-Leitner

Department of Obstetrics and Gynecology Faculty Papers

Background: Currently available immunological tests for SARS-CoV-2 assess only antibody responses. Despite the growing evidence that T cells play a crucial role in protection, especially against emerging viral variants, no routine test is available to determine T cell immunity. The prognostic value of SARS-CoV-2-specific antibodies for determining whether individuals are immune and protected against disease remains uncertain. This is in part due to the following: (a) specificity and limitations such as the sensitivity of antibody tests, and (b) the lack of correlation between antibody titers (quantity) and the antiviral function of antibodies (quality). Approximately a quarter of SARS-CoV-2-infected patients with …


The Covid-19 Pandemic And College Students' Experiences: A Phenomenological Study, Mervin L. Davis Sep 2025

The Covid-19 Pandemic And College Students' Experiences: A Phenomenological Study, Mervin L. Davis

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore and comprehend the lived experiences of college students at North Carolinian colleges and universities during the interruption and transitions of studies amid the COVID-19 pandemic. This research used qualitative inquiry design and employed Schlossberg’s transition theory to guide the study. Schlossberg’s transition theory correlates with this research and phenomenological exploration because it underscores the varying abilities and incapacities of students to persist through their studies during challenging circumstances. The setting for this research was North Carolinian higher education institutions within Mecklenburg County which boast 17 colleges and universities within a 50-mile …


Sars-Cov-2 Nsp13 Interacts With Tead To Suppress Hippo-Yap Signaling, Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin Sep 2025

Sars-Cov-2 Nsp13 Interacts With Tead To Suppress Hippo-Yap Signaling, Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin

Faculty, Staff and Students Publications

The Hippo pathway controls organ development, homeostasis, and regeneration primarily by modulating YAP/TEAD-mediated gene expression. Although emerging studies report Hippo-YAP dysfunction after viral infection, it is largely unknown in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we analyzed RNA sequencing data from human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and SARS-CoV-2-infected human lung samples, and observed a decrease in YAP target gene expression. In screening SARS-CoV-2 nonstructural proteins, we found that nonstructural protein 13 (NSP13), a conserved coronavirus helicase, inhibits YAP transcriptional activity independent of the upstream Hippo kinases LATS1/2. Consistently, introducing NSP13 into mouse cardiomyocytes suppresses …


Adaptive Ensemble Approaches For Face Mask Detection Using Transfer Learning Model, Faisal Alshanketi Sep 2025

Adaptive Ensemble Approaches For Face Mask Detection Using Transfer Learning Model, Faisal Alshanketi

University of Bisha Journal for Basic and Applied Sciences

Amidst the Covid-19 pandemic, wearing a mask has become mandatory and remains crucial in the ongoing pandemic. In certain situations and conditions, masks may be required periodically. However, manually monitoring large crowds of people to ensure they are wearing masks in public places or events can be an arduous task that is both time-consuming and difficult to manage. One way to address the challenge of manually monitoring mask-wearing in public places is to adopt machine learning (ML) methods and ICT-based surveillance mechanisms, thereby reducing the need for large numbers of personnel. While previous studies have proposed various machine learning models …


The New England Trail, End To End In Five Days: A Running Couple Test Their Limits, Scott Livingston Sep 2025

The New England Trail, End To End In Five Days: A Running Couple Test Their Limits, Scott Livingston

Appalachia

A moment-by-moment narrative of a grueling run from Mount Monadnock in New Hampshire to Guilford, Connecticut from June 17 through June 22, 2020.


Nurses’ Lived Experiences During The Covid-19 Pandemic: A Descriptive Phenomenological Study, Kala Mayer, Jo Anne Bennett, Elizabeth Reifsnider, Jeanie Skibiski, Soojung Jo Sep 2025

Nurses’ Lived Experiences During The Covid-19 Pandemic: A Descriptive Phenomenological Study, Kala Mayer, Jo Anne Bennett, Elizabeth Reifsnider, Jeanie Skibiski, Soojung Jo

International Nursing Research Congress (INRC)

The COVID-19 pandemic presented unprecedented challenges for nurses, including confronting end-of-life decisions, witnessing patient suffering, and burnout. Nevertheless, many nurses demonstrated resilience and personal growth despite adversities. Notable gaps in the literature include limited exploration of the long-term impacts of the pandemic on nurses, variations in experiences based on geographic, gender, and cultural factors, as well as the role of leadership and organizational response. Likewise, how nurses adapted to innovations such as new technologies and the impact of their pandemic experiences on patient outcomes and care quality remain underexplored. This study employed a phenomenological descriptive approach to capture nurses’ lived …


Pengaruh Model Pembelajaran Role Playing Terhadap Motivasi, Hasil Belajar, Dan Keterampilan Kolaboratif Siswa Kelas Xi Ips Pada Pembelajaran Biologi, Hendrawan Hendrawan, Sulisetijono Sulisetijono, Yunita Rakhmawati Aug 2025

Pengaruh Model Pembelajaran Role Playing Terhadap Motivasi, Hasil Belajar, Dan Keterampilan Kolaboratif Siswa Kelas Xi Ips Pada Pembelajaran Biologi, Hendrawan Hendrawan, Sulisetijono Sulisetijono, Yunita Rakhmawati

Journal of Innovation and Teacher Professionalism

The COVID-19 pandemic drastically changed the way learning was conducted and strongly affected the quality of education students received. These changes influenced not only motivation and learning outcomes but also essential twenty-first-century competencies, particularly collaboration. In response, role-playing emerged as a promising alternative for improving learning quality. This study aimed to examine the effects of role-playing on learning motivation, cognitive learning outcomes, and collaboration skills in the topic of human digestion during the pandemic. It used a quantitative quasi-experimental design comparing an experimental class that applied role-playing with a control class that used another equivalent learning model. The sample consisted …


Exploring The Effects Of The Covid-19 Pandemic On The Biblical Organizational Culture Of A K-12 School In Kansas, Michael Jacob Wiebe Aug 2025

Exploring The Effects Of The Covid-19 Pandemic On The Biblical Organizational Culture Of A K-12 School In Kansas, Michael Jacob Wiebe

Doctoral Dissertations and Projects

The purpose of this qualitative research design was to understand the lived experiences of K-12 Christian school teachers regarding the perceived impact of the COVID-19 pandemic on the biblical organizational culture of a school in Wichita, Kansas. A qualitative interview methodology was utilized for teachers to answer questions pertaining to their own experiences in changes within the school, the school’s environment, and the school’s level of involvement in a biblical culture during and post the COVID-19 pandemic. The data were analyzed to understand the effects and the changes the COVID-19 pandemic has had on K-12 Christian school biblical organizational culture, …


Epidemiological-Based Study Of Sars-Cov-2 In Faisalabad, Sana Ullah, Muhammad Waseem Khan, Qurat-Ul- Ain, Khushbu Farva, Niaz Muhammad Khan, Hayat Ullah Aug 2025

Epidemiological-Based Study Of Sars-Cov-2 In Faisalabad, Sana Ullah, Muhammad Waseem Khan, Qurat-Ul- Ain, Khushbu Farva, Niaz Muhammad Khan, Hayat Ullah

Biological Engineering Student Research

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raced around the world across different populations; there needs to be a consolidated effort to understand the divergence of the epidemiology of SARS-CoV-2. Population-based epidemiological characteristics studies measure the extent of SARS-CoV-2 infection in a country. The current research study was designed to report epidemiological data from Pakistan. For this purpose, 246 SARS-CoV-2-infected patients were included in the study. For SARS-CoV-2 confirmation, viral samples were collected from all the study participants; SARS-CoV-2 infection was confirmed by viral nucleic acid detection using a nucleic acid detection kit. After SARS-CoV-2 confirmation, all the study participants …


Crossroads Of Covid-19 And Alzheimer’S: Investigating Sars-Cov-2 Nsp6 And Orf7a In Amyloid-Β42 Toxicity, Jeffrey William Huettemann, Amit Singh Aug 2025

Crossroads Of Covid-19 And Alzheimer’S: Investigating Sars-Cov-2 Nsp6 And Orf7a In Amyloid-Β42 Toxicity, Jeffrey William Huettemann, Amit Singh

Research from the Berry Summer Thesis Institute, 2025

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in several hundred million contracted cases of coronavirus disease 2019 (COVID-19) and a global pandemic. In some of these cases, previous neurological diseases, such as Alzheimer’s disease (AD), seemed to progress much more rapidly after the COVID-19 infection. Thus, we became interested in studying the effects of SARS-CoV-2 infection on prior neurological disease progressions.

To modulate this condition, we used Drosophila melanogaster as a genetic model system. We had previously developed the Alzheimer’s Disease Fly Model with expression of human amyloid beta 42 (Aβ42) peptide, which is responsible for extracellular Aβ-42 …


Causes Of Symptoms And Symptom Persistence In Long Covid And Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Anthony L Komaroff, Robert Dantzer Aug 2025

Causes Of Symptoms And Symptom Persistence In Long Covid And Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Anthony L Komaroff, Robert Dantzer

Faculty, Staff and Student Publications

Debilitating symptoms for many years can follow acute COVID-19 ("long COVID"), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and various post-acute infection syndromes (PAISs). Together, long COVID and ME/CFS affect 60-400 million individuals, globally. Many similar underlying biological abnormalities have been identified in both conditions including autoantibodies against neural targets, endothelial dysfunction, acquired mitochondrial dysfunction, and a pro-inflammatory gut microbiome. Each of these abnormalities may directly cause some of the symptoms. In addition, the symptoms also may be caused by ancient, evolutionarily conserved symptomatic and metabolic responses to vital threats-sickness behavior and torpor-responses mediated by specific, recently discovered neural circuits. These neural …


The Association Of Adult Medicaid Beneficiaries’ Characteristics And Their Experience During The Covid-19 Pandemic, Frank R. Tortorella Aug 2025

The Association Of Adult Medicaid Beneficiaries’ Characteristics And Their Experience During The Covid-19 Pandemic, Frank R. Tortorella

Dissertations and Theses (Open Access)

Background: The COVID-19 pandemic disrupted the United States’ safety net program, Medicaid, for low-income individuals affecting access to care, increasing enrollment, and requiring new approaches to care delivery. The literature shows that beneficiaries’ personal characteristics influence their healthcare experience. This study investigated the association between Medicaid beneficiary characteristics and experience with their Medicaid health plan, examined if COVID-19 negatively impacted experience, and tested if COVID-19 moderated the relationship between beneficiary characteristics and experience.

Methods: The research sample was 76,976 adult Medicaid beneficiaries who voluntarily completed the annual Consumer Assessment of Healthcare Providers and Systems (CAHPS) health plan surveys in 2018 …


A Comparative Subnational Policy Analysis Of State Covid-19 Vaccine Policies And Application Of The Political Determinants Of Health Model, Demetrius Cianci Chapman Aug 2025

A Comparative Subnational Policy Analysis Of State Covid-19 Vaccine Policies And Application Of The Political Determinants Of Health Model, Demetrius Cianci Chapman

Nursing ETDs

A COMPARATIVE SUBNATIONAL POLICY ANALYSIS OF STATE COVID-19 VACCINE POLICIES AND APPLICATION OF THE POLITICAL DETERMINANTS OF HEALTH MODEL

By

Demetrius Cianci Chapman

Associate of Science Nursing, Jewish Hospital College of Nursing and Allied Health, 1998

Bachelor of Science of Nursing, Saint Louis University, 2000

Master of Public Health, Saint Louis University, 2004

Master of Science Nursing (Research), Saint Louis University, 2004

Doctor of Philosophy, Nursing, University of New Mexico, 2025

ABSTRACT

This study uses the political determinants of health (PDoH) framework to analyze state-level COVID-19 vaccine policies and their impact on population health. The PDoH model examines how structured …


Variability In Long Covid Definitions And Validation Of Published Prevalence Rates, Lauren E. Wisk, Michelle L'Hommedieu, Kate Diaz Roldan, Imtiaz Ebna Mannan, Erica S. Spatz, Robert A. Weinstein, Arjun K. Venkatesh, Michael Gottlieb, Ryan Huebinger, Kristin L. Rising, Juan Carlos C. Montoy, Kari A. Stephens, Robert M. Rodriguez, Mandy J. Hill, Kelli N. O'Laughlin, Nicole L. Gentile, Ahamed H. Idris, Shu-Xia Li, Michelle Santangelo, Efrat R. Kean, Samuel A. Mcdonald, Kristyn Gatling, Joann G Elmore Aug 2025

Variability In Long Covid Definitions And Validation Of Published Prevalence Rates, Lauren E. Wisk, Michelle L'Hommedieu, Kate Diaz Roldan, Imtiaz Ebna Mannan, Erica S. Spatz, Robert A. Weinstein, Arjun K. Venkatesh, Michael Gottlieb, Ryan Huebinger, Kristin L. Rising, Juan Carlos C. Montoy, Kari A. Stephens, Robert M. Rodriguez, Mandy J. Hill, Kelli N. O'Laughlin, Nicole L. Gentile, Ahamed H. Idris, Shu-Xia Li, Michelle Santangelo, Efrat R. Kean, Samuel A. Mcdonald, Kristyn Gatling, Joann G Elmore

Jefferson Center for Connected Care Faculty Papers

IMPORTANCE: Long COVID definitions vary widely, and no consensus exists on how to accurately measure its prevalence, complicating both clinical care and research.

OBJECTIVE: To assess long COVID prevalence using various definitions from published literature.

DESIGN, SETTING, AND PARTICIPANTS: This prospective, multicenter cohort study used data from the longitudinal Innovative Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE). Participants aged 18 years or older with symptoms suggestive of COVID-19 illness at the time of their index SARS-CoV-2 test enrolled at 8 sites across the US from December 11, 2020, through August 29, 2022, with follow-up surveys collected through February 28, …


Ai-Driven Biomedical Perspectives On Mental Fatigue In The Post-Covid-19 Era: Trends, Research Gaps, And Future Directions, Saba Parveen, Md Belal Bin Heyat, Umair Tariq, Faijan Akhtar, Hafiz Muhammad Zeeshan, Seth Christopher Yaw Appiah, Shang-Ming Zhou, Huang Lei Aug 2025

Ai-Driven Biomedical Perspectives On Mental Fatigue In The Post-Covid-19 Era: Trends, Research Gaps, And Future Directions, Saba Parveen, Md Belal Bin Heyat, Umair Tariq, Faijan Akhtar, Hafiz Muhammad Zeeshan, Seth Christopher Yaw Appiah, Shang-Ming Zhou, Huang Lei

School of Nursing and Midwifery

Mental fatigue is a complex condition arising from various neurological processes and influenced by external factors such as stress and cognitive demands. This comprehensive review elucidates the primary neurological mechanisms underlying mental fatigue, particularly emphasizing how it was elevated or otherwise affected during the COVID-19 pandemic. We explore the intricate relationship between prolonged cognitive tasks, chronic stress, and the development of mental fatigue, emphasizing the impacts that mental fatigue has on mental health across diverse populations. Utilizing advanced artificial intelligence techniques, including machine learning and deep learning, this study identifies and quantifies the patterns of mental fatigue. The innovative approach …


Micbg406a Polymorphism Reduces Risk Of Mechanical Ventilation And Death During Viral Acute Lung Injury, Harry Pickering, Narges Alipanah-Lechner, Ernie Chen, Dylan Duchen, Holden T Maecker, Seunghee Kim-Schulze, Ruth R Montgomery, Chris Cotsapas, Hanno Steen, Florian Krammer, Charles R Langelier, Ofer Levy, Lindsey R Baden, Esther Melamed, Lauren Ir Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Charles B Cairns, Elias K Haddad, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, David J Erle, Joanna Schaenmann, Al Ozonoff, Bjoern Peters, Steven H Kleinstein, Alison D Augustine, Joann Diray-Arce, Patrice M Becker, Nadine Rouphael, Matthew C Altman, Steve Bosinger, Walter Eckalbar, Carolyn S Calfee, Oscar A Aguilar, Elaine F Reed, John R Greenland, Daniel R Calabrese Aug 2025

Micbg406a Polymorphism Reduces Risk Of Mechanical Ventilation And Death During Viral Acute Lung Injury, Harry Pickering, Narges Alipanah-Lechner, Ernie Chen, Dylan Duchen, Holden T Maecker, Seunghee Kim-Schulze, Ruth R Montgomery, Chris Cotsapas, Hanno Steen, Florian Krammer, Charles R Langelier, Ofer Levy, Lindsey R Baden, Esther Melamed, Lauren Ir Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Charles B Cairns, Elias K Haddad, Albert C Shaw, David A Hafler, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Monica Kraft, Chris Bime, David J Erle, Joanna Schaenmann, Al Ozonoff, Bjoern Peters, Steven H Kleinstein, Alison D Augustine, Joann Diray-Arce, Patrice M Becker, Nadine Rouphael, Matthew C Altman, Steve Bosinger, Walter Eckalbar, Carolyn S Calfee, Oscar A Aguilar, Elaine F Reed, John R Greenland, Daniel R Calabrese

Faculty, Staff and Students Publications

MHC class I polypeptide-related sequence B (MICB) is a ligand for NKG2D. We have shown NK cells are central to lung transplant acute lung injury (ALI) via NKG2D activation, and increased MICB in bronchoalveolar lavage predicts ALI severity. Separately, we found a MICB polymorphism (MICBG406A) is associated with decreased ALI risk. We hypothesized this polymorphism would protect against severe SARS-CoV-2 respiratory disease. We analyzed 1,036 patients hospitalized with SARS-CoV-2 infection from IMPACC. Associations between MICBG406A and outcomes were determined by linear regression or Cox proportional hazards models. We also measured immune profiles of peripheral blood and the upper and lower …


Understanding How The Spiritual Formation Process Has Been Affected In A Post-Covid 19 World, Matthew E. Hunter Aug 2025

Understanding How The Spiritual Formation Process Has Been Affected In A Post-Covid 19 World, Matthew E. Hunter

Doctoral Dissertations and Projects

The need for community is essential in the life of the believer. Without a solid community, a believer may fall into isolation and even driven away from God instead of closer to Him. Psychologists have stated that community impacts human cognitive and moral development. James Fowler takes this a step further, outlined a believer’s stages of faith compared to human development. These levels of development directly impact the spiritual formation process in the life of a believer and demonstrate the vital role it plays in the believer’s life. Discipleship remains an important tool for helping a believer move through these …


Sustained Lung Inflammation Post-Sars-Cov-2 Infection In Mice Is Associated With Increased Pulmonary T Cells., Sophie Y Guan, Patricia P Ogger, Ana Farias, Minerva Garcia Martín, Joy Nakawesi, Olivia Bedard, Candice N Baker, Nadia Rosenthal, Cecilia Johansson Aug 2025

Sustained Lung Inflammation Post-Sars-Cov-2 Infection In Mice Is Associated With Increased Pulmonary T Cells., Sophie Y Guan, Patricia P Ogger, Ana Farias, Minerva Garcia Martín, Joy Nakawesi, Olivia Bedard, Candice N Baker, Nadia Rosenthal, Cecilia Johansson

Faculty Research 2025

Many SARS-CoV-2 patients experience chronic pulmonary symptoms and long-term inflammation despite viral clearance. While these clinical manifestations have been linked to the dysregulation of the adaptive immune response, the underlying immunopathology remains poorly understood due to a lack of suitable animal models. To investigate long-term pulmonary consequences of SARS-CoV-2 infection, we used a genetic cross of 129 mice and C57BL/6 (B6)-K18-hACE2 transgene mice, a model previously shown to survive infection. 129xB6-K18-hACE2 mice or littermate controls were infected with a low dose (5 × 102 PFU) of ancestral SARS-CoV-2. Complete viral clearance and full recovery from weight loss …


Chance Or Strategy? Assessing The Unanticipated Policy Window For Active Transportation During The Covid-19 Pandemic: A Systematic Review, Katja Siefken, Michael Pratt, Juliana Mejía-Grueso, Adrian Bauman, Deborah Salvo, Catherine B Woods, Wanda Wendel-Vos, Justin Richards, J Jaime Miranda, Pedro C Hallal, Andrea Ramírez Varela Aug 2025

Chance Or Strategy? Assessing The Unanticipated Policy Window For Active Transportation During The Covid-19 Pandemic: A Systematic Review, Katja Siefken, Michael Pratt, Juliana Mejía-Grueso, Adrian Bauman, Deborah Salvo, Catherine B Woods, Wanda Wendel-Vos, Justin Richards, J Jaime Miranda, Pedro C Hallal, Andrea Ramírez Varela

Faculty, Staff and Student Publications

Physical activity (PA) policy is essential for promoting population-level PA by coordinating efforts across various sectors. Global crises like the COVID-19 pandemic can open policy windows, enabling rapid implementation of innovative policies. This study examined how policy windows shaped active transportation (AT) policies during the pandemic, resulting in infrastructural changes.

Methods: A systematic review using PubMed, Scopus, ProQuest-Coronavirus Research Database, Web of Science, WHO COVID-19 Research Database, PsycInfo, and SPORTDiscus conducted to characterize AT policy during the pandemic (2020-2023). Descriptive analyses were conducted in Stata. PROSPERO registration number: CRD42025644930.

Results: The search retrieved 3879 articles; 1162 were duplicates, leaving 2716 …


An Electronic Trigger To Detect Telemedicine-Related Diagnostic Errors, Daniel R Murphy, Himabindu Kadiyala, Li Wei, Hardeep Singh Aug 2025

An Electronic Trigger To Detect Telemedicine-Related Diagnostic Errors, Daniel R Murphy, Himabindu Kadiyala, Li Wei, Hardeep Singh

Faculty, Staff and Students Publications

Introduction

The COVID-19 pandemic advanced the use of telehealth-facilitated care. However, little is known about how to measure safety of clinical diagnosis made through telehealth-facilitated primary care.

Methods

We used the seven-step Safer Dx Trigger Tool framework to develop an electronic trigger (e-trigger) tool to identify potential missed opportunities for more timely diagnosis during primary care telehealth visits at a large Department of Veterans Affairs facility. We then applied the e-trigger algorithm to electronic health record data related to primary care visits during a 1-year period (1 April 2020–31 March 2021). The algorithm identified patients with unexpected visits within 10 …


The Effectiveness Of Remote Patient Monitoring In Reducing The Risk Of Rehospitalizations In Covid-19 Patients: A Meta-Analysis, Dela Riadi, Indang Trihandini, Dewi Nirmala Sari, Fikri Wijaya Jul 2025

The Effectiveness Of Remote Patient Monitoring In Reducing The Risk Of Rehospitalizations In Covid-19 Patients: A Meta-Analysis, Dela Riadi, Indang Trihandini, Dewi Nirmala Sari, Fikri Wijaya

Kesmas

An integrated analysis of various Remote Patient Monitoring (RPM) studies is needed to evaluate the reduction rate of the risk of rehospitalization in COVID-19 patients. This meta-analysis aimed to provide an overview of the effectiveness of RPM. A literature search through online databases (PubMed, Science Direct, Scopus, ProQuest, and Embase) was conducted from 2019 to 2022. After using the Cochrane Collaboration's risk of bias tool, five studies on COVID-19 were selected. Based on the data collected from 2,685 participants (intervention = 1,060, control = 1,625), the use of RPM was found to reduce rehospitalization by 0.56 times compared to not …


Islamic Finance Performance During Crises: A Bibliometric Mapping And A Systematic Literature Review, Amel Farhat, Amal Hili, Ibtissem Gannoun Jul 2025

Islamic Finance Performance During Crises: A Bibliometric Mapping And A Systematic Literature Review, Amel Farhat, Amal Hili, Ibtissem Gannoun

Journal of King Abdulaziz University: Islamic Economics

This study assesses the claim that Islamic finance, with its risk-sharing, low levels of indebtedness, and asset-backed characteristics, offers a viable alternative to conventional finance during crises. Through bibliometric mapping and a systematic literature review, we explore the performance of Islamic financial systems during various crises, including the recent COVID-19 pandemic. Using VOSviewer and RStudio, we analyze 555 articles from the Scopus database to identify prominent clusters in Islamic finance, particularly focusing on its resilience during crises. Our review provides theoretical evidence supporting the robustness of Islamic finance, highlighting its ethical features and its capability to safeguard investments during economic …