Digital Commons Network^™

Effect Of Paxlovid On Neurodevelopmental Disorder Diagnosis Outcomes In Offspring Of Mothers Infected With Sars-Cov-2 During Pregnancy, Simone Rogers

CMC Senior Theses

The onset of the 2020 COVID-19 pandemic brought concern over the effects that this virus would have on pregnancy and fetal outcomes, specifically neurodevelopmental outcomes. Maternal immune activation (MIA), caused by infection during pregnancy, is known to result in neurodevelopmental disorder (NDD) diagnosis in offspring, typically autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). This effect has already been observed in mothers who were infected with COVID-19 during pregnancy. However, in 2023, Paxlovid, the COVID-19 antiviral drug, became available to patients experiencing symptoms of the virus, including pregnant women. Consequently, this study seeks to determine whether the risk of …

Cause Of Death? -- It's Probably Not What's Reported On The Death Certificate, Lauren R. Roth

Lewis & Clark Law Review

In the age of big data, this country has a data problem—inaccurate and incomplete information in death certificates. The problem has long been hidden by the numbers reported—as have the people whose deaths go uncounted, but the COVID-19 pandemic unveiled the scope of the issue. Since the beginning of the pandemic, “excess deaths” (i.e., any deaths above the number predicted by existing mortality models) have increased significantly. Most of these excess deaths are likely attributable to COVID-19 because the decedent was never tested for COVID-19 or it was one of multiple factors contributing to their death. Other deaths are uncounted …

Opportunity Restored: Using Creative Measures To Provide Students With Academic Advancement Opportunities Lost During Covid-19, Randal Clint Jordan

Electronic Theses and Dissertations

This mixed-methods action research study examines the Fast Track and Graduation Path (FTGP) programs—equity-focused interventions developed to offer opportunity to students who experienced academic disruption during COVID-19 emergency schooling (Creswell & Plano Clark, 2018). The programs targeted students retained due to socioeconomic status, learned helplessness, or the technology learning gap, rather than a lack of ability or low prior performance (Jenson, 2013; Maier & Seligman, 1976; Bower, 2019). FTGP provided structured academic pathways, daily facilitation, technology-based instruction, and character education to rebuild learner confidence and achievement (Reimer & Hill, 2022).

Quantitative data from the Edgenuity© learning platform revealed the program’s …

Special Educator Persistence: Unveiling Teacher Perceptions, Janet Nutt

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

There is a continually growing shortage of special education teachers (SET). The shortage is so dire that the U.S. Bureau of Labor Statistics (2024) anticipates that as many as 35,900 new SET will be needed each year for the next decade. One of the leading factors contributing to the shortage of special educators is attrition, or any loss of teachers from their positions (Darling-Hammond, 2003; Ingersoll, 2001). Teacher persistence, therefore, is a critical concern in addressing the teacher shortage. The purpose of this mixed-methods research study is to examine the association between previously identified factors of attrition and SET decisions …

Prevalence Of Covid-19 Associated Xerostomia, Taste And Smelldisturbances Over 3 Years In An Egyptian Sample: A Cross-Sectional Study, Dalia Ghalwash, Ahmed Hamdy, Asmaa Abou-Bakr

Dentistry

Aim: Although xerostomia, smell, and taste dysfunctions are prominent signs of COVID-19 infection, long-term data regarding their prevalence and recovery rates is scarce. Accordingly, this study aimed to evaluate the frequency and persistence of xerostomia, taste, and smell disturbances in COVID-19 survivors over 3 years in an Egyptian sample. Methods: This cross-sectional study used an online questionnaire to assess the oral symptoms ofxerostomia, which include altered taste and smell. Data was collected from 826 patients recovered from COVID-19. Results: Xerostomia was the most frequent finding affecting 73.6% of the studied sample, followed bysmell disturbances affecting 67.8%, and altered taste reported …

Scrolling For Two: An Exploration Of Pregnant Women's Social Support And Information Seeking Behaviors Using Technology During The Covid-19 Pandemic, Sarah Knowlton

Theses and Dissertations

Pregnant women faced additional challenges in accessing reliable support and pregnancy- related information, leading to increased distress during the COVID-19 pandemic. Quarantine measures limited doctor’s appointments and isolated pregnant women from their families, which meant that meaningful connections and convenient information was important.

The purpose of this study is to explore the implications of COVID-19 social distancing on pregnant women, with a focus on three questions: 1) what digital technologies did pregnant women use for support and information seeking purposes during the pandemic? 2) how did pregnant women use technology to seek social support during the pandemic? 3) how did …

Exploring The Determinants Of Life Expectancy At Birth: Predicting And Forecasting Global Health Trends Using Statistical, Machine Learning, And Deep Learning Models., Emma Rath

ICT

Accurate life expectancy forecasting is essential for health policy planning, yet research comparing statistical, machine learning, and deep learning approaches under real-world constraints remains limited. This study evaluates ARIMA/ARIMAX, tree-based, and neural network models using Irish and global datasets, considering small samples, missing data, and COVID-19 shocks. ARIMAX with lagged socioeconomic variables outperformed LSTM and other ML/DL methods. Income-based stratification improved predictive accuracy and interpretability, with SHAP analysis highlighting GDP per capita for developed countries and school enrolment and trade indicators for developing contexts. Results provide practical guidance for policymakers and establish limits for model complexity under constrained health data.

Enhancing Operational Efficiency Of Paratransit Services Using Predictive Models, Troyee Saha

Civil Engineering Dissertations - Archive

Paratransit services play a vital role in supporting the mobility of older adults and individuals with disabilities, yet they experienced major disruptions during the COVID-19 pandemic and continue to face ongoing operational issues such as trip cancellations. This dissertation explores these challenges through three distinct analyses using data from Arlington, TX. The first chapter investigates how COVID-19-related factors (policies, cases, and vaccination) and socio-demographics influenced paratransit usage from 2019 to 2021. Applying SARIMAX and Poisson regression models, the study finds a substantial drop in ridership—41% in 2020—and a shift toward essential medical travel. It also reveals that restrictive policies, such …

"The Perfect Storm": Weathering Black Racial Trauma Across The Lifespan And The Impact Of Covid-19, Taryne M. Mingo, Kiauhna Haynes

Adultspan Journal

Descendants of Africans Enslaved in the United States (DAEUS), who lived in the South prior to 1965 and experienced decades of legalized discrimination, were found to have been disproportionately impacted by the COVID-19 pandemic. Arline Geronimus (1992) coined the term “weathering” to acknowledge the accumulation of racial trauma stored within the body over extended periods of time. The purpose of this interpretive phenomenological study, aligned by the tenets of Critical Race Theory, explores how continuous racial trauma impacted DAEUS citizens’ well-being and trust in the COVID-19 vaccine. Three Group Experiential Themes emerged during this study, all connected with the experiences …

Detecting Sars-Cov-2 In Ct Scans Using Vision Transformer And Graph Neural Network, Kamorudeen Amuda, Almustapha Wakili, Tomilade Amoo, Lukman Agbetu, Qianlong Wang, Jinjuan Feng

Electrical & Computer Engineering Faculty Publications

The COVID-19 pandemic has presented significant challenges to global healthcare, bringing out the urgent need for reliable diagnostic tools. Computed Tomography (CT) scans have proven instrumental in detecting COVID-19-induced lung abnormalities. This study introduces Convolutional Neural Network, Graph Neural Network, and Vision Transformer (ViTGNN), an advanced hybrid model designed to enhance SARS-CoV-2 detection by combining Graph Neural Networks (GNNs) for feature extraction with Vision Transformers (ViTs) for classification. Using the strength of CNN and GNN to capture complex relational structures and the ViT capacity to classify global contexts, ViTGNN achieves a comprehensive representation of CT scan data. The model was …

The Development Of A One Pot, Two Reaction Synthetic Preparation Of 1,2,4-Oxadiazole, And Synthesis Of Ataluren, A Novel Drug In The Fight Against Duchenne Muscular Dystrophy. Efforts Towards The Synthesis Of A Potential Protease Inhibitor Against The Main Protease (3clpro) Of Covid-19, Austin J. Carter

Theses and Dissertations

1,2,4-Oxadiazoles are five-membered heterocyclic structures first synthesized by Tiemann and Krüger in 1884. Recent discoveries suggest an array of useful biological properties.In preparation of 1,2,4-oxadiazoles, the most prevalent precursors are amidoximes, which can be created via the reaction of nitriles with hydroxylamine hydrochloride and a base. The amidoximes are reacted with an activated carboxylic acid to yield an acylated intermediate. This intermediate can be exposed to a base to cyclize into the 1,2,4-oxadiazole. This thesis describes the efforts in combining these three steps into a unified one-pot synthesis.

Currently, there are a significant number of commercially available FDA approved and …

Covid-19'S Impact On Grocery Expenditure Amid The Rise Of Social Media's Unattainable Wellness Culture Within Beverage Products, Ava Hinz

Scripps Senior Theses

This paper explores post-pandemic consumption through two different lens: economics and media studies. First, I will focus on COVID-19’s impact on the expenditure of grocery goods. Then I will explore how today’s wellness culture is made unattainable through social media by examining an organic grocery store and two beverage products. By examining these two areas of consumption, it provides critical information on an individual’s consumption during the unique shocks of the pandemic and the cultural context behind those actions.

Children's Interpretation Of Others' Faces Covered With Medical Masks, Sevval Cinar

Theses and Dissertations (Comprehensive)

How we recognize and regulate emotions is fundamental to overall health and wellbeing. Emotional recognition and understanding are key to proper communication and emotion regulation. Barriers, such as masks, might have an impact on the way children recognize and interpret others' emotions, and therefore the way they learn, communicate, and regulate their own. The COVID-19 pandemic necessitated widespread mask-wearing, raising questions about its impact on children’s emotional development. Using a sample of children with varying levels of exposure to mask wearing adults (N= 13, ages 4 to 6), we investigated how prolonged mask wearing predicts emotion recognition, particularly …

Association Between Primary Covid-19 Vaccine Type And Booster Uptake Among Incarcerated People In Connecticut: A Retrospective Cohort Study, Michael Condon Elhardt

Public Health Theses

Importance: Booster doses of the COVID-19 vaccine are critical for maintaining protection against SARS-CoV-2, especially in high-risk settings such as correctional facilities. Understanding how initial vaccine type influences booster uptake can inform vaccination strategies in these and other underserved populations.Objective: To assess whether the type of COVID-19 vaccine received for the primary series—either viral vector (Janssen/Jcovden) or mRNA (Moderna/Spikevax or Pfizer-BioNTech/Comirnaty)—was associated with timing or likelihood of booster completion among incarcerated individuals. Design: Retrospective cohort study using survival analysis methods. The study period spanned from February 2, 2021, to May 31, 2023. Setting: Connecticut Department of Correction (DOC) facilities, including …

Learning Dissemination Strategies: Lessons From The Covid-19 Pandemic In Training Healthcare Professionals In Disease Management, Kishan Vishanagra

Honors Undergraduate Theses

The COVID-19 pandemic presented many challenges for global healthcare systems, requiring rapid training and dissemination of disease management strategies among healthcare professionals. This study conducts a systematic review of 37 studies to examine the learning dissemination methods created and utilized during the COVID-19 pandemic, focusing on just-in-time training for disease management. This study identifies four core training topics: airway management, infection control, cardiopulmonary resuscitation, and patient triage. This study also categorizes delivery methods into in-situ simulation-based training, online e-learning platforms, online simulation-based training, and hybrid training models. Findings highlight that simulation-based training methods proved effective for invasive high-risk procedures, while …

Phenotypic Variation In Disease Severity Among Hospitalized Pediatric Patients With Covid-19: Assessing The Impact Of Covid-19 In The Epico Study, María Camila Sossa-Alarcón, Mónica Paola Gutiérrez, Natalia Becerra, Luz Yessenia Ortegon, María Camila David, Melisa Naranjo Vanegas, Gabriela Friedrich, Pablo Vásquez-Hoyos, María Lucía Mesa-Rubio, Luis Miguel Navarro-Ramirez, Sergio Moreno-Lopez, Olga Lucía Baquero, Luz Marina Mejía, Juan Gabriel Piñeros, Sonia Restrepo-Gualteros, Carlos Álvarez-Moreno, Alejandro Díaz-Díaz, Iván Gutierrez-Tobar, Andrés Camilo Mesa, William Ricardo Bachiller Tuta, Clara Esperanza Galvis Diaz, Martha Africano, José Manuel Nieto, Paola Marsela Pérez Camacho, Claudia Beltrán-Arroyave, Rosalba Vivas Trochez, Irati Gastesi, Cinta Moraleda, Alfredo Tagarro García, Blanca Herrero, Lourdes Calleja, Carlos Grasa, Paula Rodriguez, Susana Melendo, Antoni Soriano-Arandes, Irene Gómez Pastrana, Sonsoles García García, Victoria Fumado, Andrea Ramírez Varela

Faculty, Staff and Student Publications

Objective: To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study.

Methods: We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes.

Results: A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, …

Association Between Trust In The Incumbent President And Covid-19 Preventive Behaviors During The Pandemic In Four Latin American Countries, Juliana Mejía-Grueso, Gloria Isabel Niño-Cruz, Javiera Alarcón-Aguilar, Pablo Roa-Urrutia, Sergio Mauricio Moreno-López, Adriano Akira Ferreira Hino, Alexandre Augusto De Paula Da Silva, Fernando López, Deborah Salvo, Rodrigo Siqueira Reis, Guillermo Rosas, Andrea Ramírez-Varela

Faculty, Staff and Student Publications

The COVID-19 pandemic revealed disparities in policy responses in Latin America. We examined the association between trust in the president and COVID-19 preventive behaviors in Brazil, Chile, Colombia, and Mexico. We used data from the Collaborative COVID-19 Response Survey by the McDonnell Academy at Washington University in St. Louis (United States), from September 2020 to March 2021. Nonprobabilistic sampling included adult citizens from the four countries. Multivariate negative binomial regression models were applied. The study included 8,125 participants, with Brazil showing the lowest adherence to preventive behaviors (65.5%). Increased adoption of preventive behaviors was linked with ages 18-26 (aIRR = …

Quantitatively Assessing The Impact Of The Quality Of Snomed Ct Subtype Hierarchy On Cohort Queries, Xubing Hao, Xiaojin Li, Yan Huang, Jay Shi, Rashmie Abeysinghe, Cui Tao, Kirk Roberts, Guo-Qiang Zhang, Licong Cui

Faculty, Staff and Student Publications

Objective: SNOMED CT provides a standardized terminology for clinical concepts, allowing cohort queries over heterogeneous clinical data including Electronic Health Records (EHRs). While it is intuitive that missing and inaccurate subtype (or is-a) relations in SNOMED CT reduce the recall and precision of cohort queries, the extent of these impacts has not been formally assessed. This study fills this gap by developing quantitative metrics to measure these impacts and performing statistical analysis on their significance.

Material and methods: We used the Optum de-identified COVID-19 Electronic Health Record dataset. We defined micro-averaged and macro-averaged recall and precision metrics to assess the …

Quantitatively Assessing The Impact Of The Quality Of Snomed Ct Subtype Hierarchy On Cohort Queries, Xubing Hao, Xiaojin Li, Yan Huang, Jay Shi, Rashmie Abeysinghe, Cui Tao, Kirk Roberts, Guo-Qiang Zhang, Licong Cui

Faculty, Staff and Student Publications

Objective: SNOMED CT provides a standardized terminology for clinical concepts, allowing cohort queries over heterogeneous clinical data including Electronic Health Records (EHRs). While it is intuitive that missing and inaccurate subtype (or is-a) relations in SNOMED CT reduce the recall and precision of cohort queries, the extent of these impacts has not been formally assessed. This study fills this gap by developing quantitative metrics to measure these impacts and performing statistical analysis on their significance.

Material and methods: We used the Optum de-identified COVID-19 Electronic Health Record dataset. We defined micro-averaged and macro-averaged recall and precision metrics to assess the …

Trends In Contacts Made By Immigrants To The National Domestic Violence Hotline, Before And During The Covid-19 Pandemic, Sarah Treves-Kagan, Vi D Le, Liris S Berra, Colleen M Ray, Yanet Ruvalcaba, Leila Wood, Denise V D'Angelo, Tatiana M Vera, Lianne Fuino Estefan

Faculty, Staff and Student Publications

Objectives: Immigrants in the United States are more likely than nonimmigrants to experience risk factors for intimate partner violence (IPV) and problems in getting support. The COVID-19 pandemic and recent incidents of xenophobia and anti-immigrant sentiment may have exacerbated exposure to IPV risk factors. We examined immigrant experiences of IPV before and during the COVID-19 pandemic.

Methods: This study identified changes in characteristics of abuse, services used, referrals, and barriers to services among those who contacted the National Domestic Violence Hotline (NDVH) and identified as immigrants, reported immigration status as a concern, needed immigration support, and/or identified immigration status as …

The Impact Of Covid-19 Pandemic Demands On By-Law Officer Wellness And Work, Harveen Randhawa

Theses and Dissertations (Comprehensive)

This research sheds light on how the rapid demand to enforce transitioning pandemic-related (and reopening) mandates impacts the wellness of bylaw officers in the context of resource strain. Ontario bylaw officers are at the forefront of the province’s response, enforcing lockdown rules to ensure community safety. This research is imperative in understanding how bylaw officers maintain their roles in municipal enforcement, while enforcing rapidly shifting COVID-19 regulations and moving forward into a post-lockdown climate. The research focuses on identifying and understanding the demands and resources that currently typify bylaw officers working in Southern Ontario. It further examines how the COVID-19 …

Forecasting Covid-19 Cases, Hospital Admissions, And Deaths Based On Wastewater Sars-Cov-2 Surveillance Using Gaussian Copula Time Series Marginal Regression Model, Hueiwang Anna Jeng, Norou Diawara, Cynthia Jackson, Rekha Singh, Kyle Curtis, Raul Gonzalez, David Jurgens, Sasanka Adikari

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Modeling efforts are needed to predict trends in COVID-19 cases and related health outcomes, aiding in the development of management strategies and adaptation measures. This study was conducted to assess whether the SARS-CoV-2 viral load in wastewater could serve as a predictor for forecasting COVID-19 cases, hospitalizations, and deaths using copula-based time series modeling. SARS-CoV-2 RNA load in wastewater in Chesapeake, VA, was measured using the RT-qPCR method. A Gaussian copula time series (CTS) marginal regression model, incorporating an autoregressive moving average model and Gaussian copula function, was used as a forecasting model. Wastewater SARS-CoV-2 viral loads were correlated with …

Effects Of Interventions For The Prevention And Management Of Maternal Anemia In The Advent Of The Covid-19 Pandemic: Systematic Review And Meta-Analysis, John Kyalo Muthuka, Diana Kageni Mbari-Fondo, Francis Muchiri Wambura, Kelly Oluoch, Japheth Mativo Nzioki, Everlyn Musanga Nyamar, Rosemary Nabaweesi

Faculty Publications

Background:The COVID-19 pandemic presented many unknowns for pregnant women, with anemia potentially worsening pregnancy outcomes due to multiple factors.

Objective:This review aimed to determine the pooled effect of maternal anemia interventions and associated factors during the pandemic.

Methods:Eligible studies were observational and included reproductive-age women receiving anemia-related interventions during the COVID-19 pandemic. Exclusion criteria comprised non-English publications, reviews, editorials, case reports, studies with insufficient data, sample sizes below 50, and those lacking DOIs. A systematic search of PubMed, Scopus, Embase, Web of Science, and Google Scholar identified articles published between December 2019 and August 2022. Risk of bias was evaluated …

Resilience Practices In Health Science And Medical Libraries During The Early Stages Of The Covid-19 Pandemic, Justin F. Gaynor

Faculty Research, Scholarly, and Creative Activity

This paper uses the concept of resilience engineering as an organizing principle to discuss best practices that evolved within health science/medical libraries in the United States during COVID-19 crisis, focusing on the period March–August 2020. Protection of library staff, assistance to medical staff, reducing the circulation of misinformation and public health consumerism all required substantial changes to standard processes. These process changes had to arise in the context of both physical isolation and information overload. Some practices became widespread due to their utility, and these are the focus of this report.

Gender-Sexuality Alliance Advisors’ Covid-19 Strategies Inform Future Responses To Sociopolitical Crises, Robert A. Marx, Michael O’Brien, Megan K. Yang, Diana Smith, V. Paul Poteat

Faculty Research, Scholarly, and Creative Activity

In the spring of 2020, the COVID-19 pandemic necessitated a sudden shift to remote learning in schools across the United States, profoundly impacting marginalized communities, including LGBTQ+ students. This qualitative study explores the experiences of Gender and Sexuality Alliance (GSA) advisors during this period. Drawing on interviews with 10 GSA advisors, the research highlights the structural and logistical challenges faced, such as limited access to technology and virtual-meeting fatigue, as well as the innovative solutions and adaptations made to continue supporting LGBTQ+ youth. The study reveals how GSAs leveraged existing resources, maintained group cohesion, and adjusted meeting structures to navigate …

Bcg-Induced Dna Methylation Changes Improve Coronavirus Disease 2019 Vaccine Immunity Without Decreasing The Risk For Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Santiago Carrero Longlax, Kent J Koster, Ashish M Kamat, Marisa Lozano, Seth P Lerner, Rebecca Hannigan, Tomoki Nishiguchi, Abhimanyu, Daanish Sheikh, Malik Ladki, Alexandra Portillo, Amrit Koirala, Tajhal D Patel, Zoe Spieler, Aaron B Benjamin, Maxim Lebedev, Theresa U Ofili, Robert W Hutchison, George Udeani, Lynne A Opperman, Gabriel Neal, Anna M Mandalakas, Mihai G Netea, Moshe Arditi, Pablo Avalos, Sandra L Grimm, Cristian Coarfa, Jeffrey D Cirillo, Andrew R Dinardo

Faculty, Staff and Students Publications

BACKGROUND: The BCG vaccine induces trained immunity, an epigenetic-mediated increase in innate immune responsiveness. Therefore, this clinical trial evaluated if BCG-induced trained immunity could decrease coronavirus disease 2019 (COVID-19)-related frequency or severity.

METHODS: A double-blind, placebo-controlled clinical trial of healthcare workers randomized participants to vaccination with BCG TICE or placebo (saline). Enrollment included 529 healthcare workers randomized to receive BCG or placebo. Primary analysis evaluated COVID-19 disease frequency, while secondary analysis evaluated coronavirus immunity in a subset of participants. Study enrollment ceased early in December 2020 following introduction of COVID-19-specific vaccines.

RESULTS: Study enrollment was halted early, prior to reaching …

Heterologous Prime-Pull Mucosal Vaccination With An Adjuvanted Rbd Vaccine Elicits Robust Iga Production And Protects Against Sars-Cov-2, Allyson H Hirsch, Calder R Ellsworth, William A Lewis, Ryan Craig, Amy E Meyer, Jonatan Maldonado, Frania Ramirez Lopez, Syamala Rani Thimmiraju, James B Mclachlan, Xuebin Qin, Nicholas J Maness, Jeroen Pollet, Ulrich Strych, Maria Elena Bottazzi, Peter J Hotez, Lisa A Morici

Faculty, Staff and Students Publications

Despite the efficacy of approved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in preventing severe disease and death, breakthrough infections continue to occur in vaccinated individuals, contributing to further viral mutation and spread. These limitations may be attributable to the poor induction of mucosal immunity by parenteral vaccination. Mucosal adjuvants, such as T-vant, can enhance vaccine-induced immune responses through the generation of antigen-specific antibodies and T cells in the respiratory tract. In this study, we evaluated the protective efficacy of adjuvanted SARS-CoV-2 receptor binding domain (RBD) subunit vaccines administered by homologous and heterologous routes. Immunized mice were challenged with …

Platypnea-Orthodeoxia And Patent Foramen Ovale In A Patient In The Setting Of Covid-19, Laura Sarmiento, Riyad Kherallah, Guilherme Vianna Silva

The Texas Heart Institute Journal

Platypnea-orthodeoxia syndrome is a rare condition characterized by positional dyspnea and hypoxemia, with symptoms presenting in the upright position and improving when recumbent. Hypoxemia in platypnea-orthodeoxia syndrome is defined as a drop in Pao

Longitudinal Host Transcriptional Responses To Sars-Cov-2 Infection In Adults With Extremely High Viral Load, Vasanthi Avadhanula, Chad J Creighton, Laura Ferlic-Stark, Divya Nagaraj, Yiqun Zhang, Richard Sucgang, Erin G Nicholson, Anubama Rajan, Vipin Kumar Menon, Harshavardhan Doddapaneni, Donna Marie Muzny, Ginger A Metcalf, Sara Joan Javornik Cregeen, Kristi Louise Hoffman, Richard A Gibbs, Joseph F Petrosino, Pedro A Piedra

Faculty, Staff and Students Publications

Current understanding of viral dynamics of SARS-CoV-2 and host responses driving the pathogenic mechanisms in COVID-19 is rapidly evolving. Here, we conducted a longitudinal study to investigate gene expression patterns during acute SARS-CoV-2 illness. Cases included SARS-CoV-2 infected individuals with extremely high viral loads early in their illness, individuals having low SARS-CoV-2 viral loads early in their infection, and individuals testing negative for SARS-CoV-2. We could identify widespread transcriptional host responses to SARS-CoV-2 infection that were initially most strongly manifested in patients with extremely high initial viral loads, then attenuating within the patient over time as viral loads decreased. Genes …

Early, Standardised, And Precise Treatment Of Copd Exacerbations And Covid-19, Sanjay Ramakrishnan

Theses: Doctorates and Masters

Background: Background Chronic Obstructive Pulmonary Disease (COPD) is a common chronic condition causing significant morbidity and mortality. Patients with COPD report sudden episodes of deteriorating respiratory symptoms called exacerbations, often presumed to be precipitated by infections. COPD is in the top 5 causes of death globally. COPD exacerbations drive a large proportion of these deaths. Despite this, there is no standardised model of care for the sickest patients who need hospitalisations for exacerbations. Meanwhile, treatment for COPD exacerbations continues to be guided by symptoms, instead of underlying biology. Most patients are treated with unnecessary and harmful systemic corticosteroids. During the …