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Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan

Turkish Journal of Biology

Human SARS coronavirus 2 (SARS-CoV-2) causes the current global COVID-19 pandemic. The production of an efficient vaccine against COVID-19 is under heavy investigation. In this study, we have designed a novel multiepitope DNA vaccine against SARS-CoV-2 using reverse vaccinology and DNA vaccine approaches. Applying these strategies led to reduce the time and costs of vaccine development and also improve the immune protective characteristics of the vaccine. For this purpose, epitopes of nucleocapsid, membrane glycoprotein, and ORF8 proteins of SARS-CoV-2 chose as targets for B and T-cell receptors. Accordingly, DNA sequences of selected epitopes have optimized for protein expression in the …

The Lived Experiences Of Selected Choral Directors During The Covid-19 Pandemic, Angela Berna Milliren

Graduate Theses, Dissertations, and Problem Reports (ETD)

The shift to online education during the COVID-19 pandemic found secondary choral teachers moving traditional performance-based courses to the online venue. The pedagogical changes needed include implementing technology and disseminating information through learning management systems. Relationships between teachers and students, and teachers and colleagues, were challenged with the physical distance of quarantines in the Spring of 2020. This dissertation research project examined the difficulties six teachers faced concerning technology and relationships. I sat down for semi-structured interviews with six colleagues where I asked about their backgrounds, relationships with students and fellow colleagues, and the changes the pandemic brought to their …

Choosing Not To Participate: Cyber Truancy And Special Education, Elizabeth A. Popielarcheck

Graduate Theses, Dissertations, and Problem Reports (ETD)

This qualitative study investigated facilitators and barriers to participation in online instruction for students in grades 9-12 with a high incidence disability from the perspective of the student and adult in the home (AIH). Three AIH-student dyads participated in questionnaires and an online interview. The interviews were recorded, transcribed verbatim, and then analyzed using the six phases described by Braun and Clarke (2006). Eight categories that aligned with barriers and facilitators to participation were identified: communication, instruction in the home, role of the AIH, attendance, grading, teacher provided student support, overall quality of online learning experience, and suggestions. Categories were …

Perceptions Of Implicit Bias In New York City Healthcare System During Covid-19, Kiesha Jackson

Walden Dissertations and Doctoral Studies

Implicit bias has been identified as a significant problem that hinders effective healthcare delivery. The purpose of this qualitative exploratory phenomenological study was to examine whether implicit bias influenced healthcare services for African Americans with comorbidities aged 30 and over living in New York City during the COVID-19 pandemic. Current studies show healthcare disparities, revealing barriers with healthcare delivery; however, they do not disclose a patient’s lived experience qualitatively, which constituted a gap in the literature. The frameworks of the behavioral model of health services use, and social construction and policy design guided this study. Research questions addressed (a) whether …

Deep Learning Augmentation For Medical Image Analysis, Fouzia Altaf

Theses: Doctorates and Masters

Deep learning is at the center of the current rise of computer aided diagnosis in medical imaging. This technology has the ability to mimic extremely complex mathematical functions for predictive tasks. These functions are encoded as computational models that are learned directly from data. Deep learning models are known to achieve human-level accuracy for predictive tasks. However, such a performance requires that the model is trained on a huge amount of training data. For computer aided diagnosis tasks, the relevant training data needs to be carefully annotated by medical experts. This process is laborious and expensive, which generally results in …

Examining The Influence Of Covid-19 On Elementary Mathematics Standardized Test Scores In A Rural Ohio School District, Dara Bright, Yiyun "Kate" Fan, Chris Fornaro, Kristin L. K. Koskey, Toni A. May, Jonathan D. Bostic, Dolores Swineford

Mid-Western Educational Researcher

In the United States, national and state standardized assessments have become a metric for measuring student learning and high-quality learning environments. As the COVID-19 pandemic offered a multitude of learning modalities (e.g., hybrid, socially distanced face-to-face instruction, virtual environment), it becomes critical to examine how this learning disruption influenced elementary mathematic performance. This study tested for differences in mathematics performance on fourth grade standardized tests before and during COVID-19 in a case study of a rural Ohio school district using the Measure of Academic Progress (MAP) mathematics test. A two-way ANOVA showed that fourth- grade MAP mathematics scores were statistically …

The Impact Of The Covid-19 Pandemic On Special Education: A Case Study, Megan Cercone

Williams Honors College, Honors Research Projects

The purpose of this research project is to explore the possible impact of the COVID-19 pandemic on special education by evaluating the experiences of one child with disabilities who attends public schools. METHODS: A semi-structured interview was conducted with the two parents of the child, who has physical disabilities and an IEP through his school, meaning he receives special education services through intervention teachers, physical therapists, occupational therapists, and speech therapists. The interview was recorded and transcribed, and then interview transcripts were evaluated to identify themes in the subjects’ responses regarding their child’s experience with public education during the pandemic. …

Themes And Associations Concerning The Covid-19 Pandemic: Autoethnography, Amber Mcgannon, Ebunoluwa O. Adedeji

Williams Honors College, Honors Research Projects

Per the college of nursing, my proposed project will discuss living during uncertain times and unusual times of change. This APA formatted paper will be an autoethnography, meaning that we will review the perspectives of COVID through the lens of culture, research, and our own perspectives and experiences. Everyone has experienced changes during the COVID-19 pandemic due to self-isolation. Examples of change include changes in learning, working, thinking, teaching, and behaving. Using acquired nursing skills such as critical thinking, reflection, inquiry, and evidenced-based practice; my partner and I will dissect and discuss these changes and how they have affected ourselves, …

Auto- Ethnography With A Deep Dive Into Changes Mental Health During The Pandemic And A Look Into The Way The Pandemic Has Shaped Nursing Protocols For Recent Nursing College Graduates, Audrey Shaffer, Sarah Bereznay

Williams Honors College, Honors Research Projects

In this project we completed a deep dive into how the Covid-19 pandemic reshaped our mental health and has affected our preparation for careers as registered nurses through a series of auto- ethnographic narrative journals using scholarly articles to support this idea. By utilizing personal narratives, we analyzed and reflected upon the cognitive and mental changes we experienced throughout this pandemic. We fulfilled this by comprising two personal narratives with inquiries pertaining to each shared narrative by utilizing the common themes of being nursing students and living through a pandemic. Within these personal narratives, we discussed how the pandemic influenced …

The Effect Of Virtual Learning As A Result Of Covid-19, Ann Redle Ms., Joel Mcmullen

Williams Honors College, Honors Research Projects

In the early spring of 2020, the United States began to experience the effects of the question-inspiring, novel COVID-19 viral illness, with the onset of massive business, school, and entertainment closures, initiating a shift towards virtual learning, communication, and professional interactions. This paper is intended to identify the common experiences of two nursing students throughout the COVID-19 pandemic by utilizing a personal narrative, or autoethnographic approach, coupled with reviews of previously published literature relating to shared themes of the authors, including the rapid changes to an online environment from traditional classroom settings, the stressors that were experienced as a result …

Assessing The Impacts Of Covid-19 On Activity-Travel Scheduling: A Survey In The Greater Toronto Area, Alireza Dianat, Jason Hawkins, Khandker Nurul Habib

Department of Civil and Environmental Engineering: Faculty Publications

The COVID-19 lockdown provided many individuals an opportunity to explore changes in their daily routines, particularly when considered in combination with an ever-changing Information and Communication Technology (ICT) landscape. These new routines and alternative activities have the potential to be continued in the post-COVID era. Transportation planners must understand how routines vary to effectively estimate activity-travel scheduling. The purpose of this study is to determine the influence of the COVID-19 pandemic lockdown on activity-travel behavior and the adoption of ICT-based alternative options. A special emphasis is placed on predicting the long-term effects of this disturbance on activity-travel scheduling. This study …

Evaluation Of Coagulation With Teg In Patients Diagnosed Covid-19, Hülya Vatansev, Mehmet Ali̇ Karaselek, Resul Yilmaz, Serkan Küççüktürk, Ahmet Topal, Şebnem Yosunkaya, Adem Küçük, Celaletti̇n Vatansev

Turkish Journal of Medical Sciences

Background and aim: A high D-dimer level may indicate the risk of coagulopathy and mortality in COVID-19 patients. Thromboelastography (TEG) is a test that evaluates clot formation and fibrinolysis in real-time, unlike routine coagulation tests. The study aimed to investigate the coagulation process with TEG in patients diagnosed with COVID-19. Materials and Methods: The study was performed at our university hospital, chest diseases outpatient clinic as a cross-section study. A total of 51 patients with 23 high D-dimer levels group (HDG) and 28 low D-dimers group (LDG) were included in the study. TEG analysis was performed at the pretreatment evaluation …

Exploring How Online Responses Change In Response To Debunking Messages About Covid-19 On Whatsapp, Xingyu Ken Chen, Jin-Cheon Na, Luke Kien-Weng Tan, Mark Chong, Murphy Choy

Research Collection Lee Kong Chian School Of Business

Purpose: The COVID-19 pandemic has spurred a concurrent outbreak of false information online. Debunking false information about a health crisis is critical as misinformation can trigger protests or panic, which necessitates a better understanding of it. This exploratory study examined the effects of debunking messages on a COVID-19-related public chat on WhatsApp in Singapore. Design/methodology/approach: To understand the effects of debunking messages about COVID-19 on WhatsApp conversations, the following was studied. The relationship between source credibility (i.e. characteristics of a communicator that affect the receiver's acceptance of the message) of different debunking message types and their effects on the length …

Rural Parent's Experiences Of Stress And Resilience During The Covid-19 Pandemic And School Closure, Emily Wilson, Jungwon Eum, Yuenjung Joo, Martinique A. Sealy, Jentry Stoneman Barrett, Gwen C. Nugent, Joan M. Carraher, Angela G. Hinrichs

Department of Child, Youth, and Family Studies: Faculty Publications

The COVID-19 pandemic has generated social and economic disruptions, resulting in cascading effects on the health and well- being of global citizens. However, little research has focused on how COVID-19 has affected rural regions, despite rurality being a critical factor for understanding community impact and response to the pandemic. The purpose of this phenomenological study was to explore the experiences of rural Nebraskan parents with young children during the COVID-19 pandemic and school shutdown, and the strategies they used to support their families during that time. We conducted individual and group interviews with 22 white, non-Hispanic mothers living in rural …

Political Ideology And Judicial Administration: Evidence From The Covid-19 Pandemic, Kyle Rozema, Adam Chilton, Christopher Anthony Cotropia, David L. Schwartz

Scholarship@WashULaw

We study the effect of political ideology on the administration of the judiciary by investigating how the chief judges of federal district courts set courthouse policies in response to the COVID-19 pandemic. To do so, we use novel data on the geographic boundaries of federal courts and on the contents of pandemic orders. We account for state and local conditions and policies by leveraging district courts in states that have multiple judicial districts and that have courthouses in multiple counties, and we isolate the effect of chief ideology by using simulations that difference out unobserved district-level effects. We find no …

Covid-19 Collaborative Modelling For Policy Response In The Philippines, Malaysia And Vietnam, Angus Hughes, Romain Ragonnet, Pavithra Jayasundara, Hoang-Anh Ngo, Elvira P. De Lara-Tuprio, Ma. Regina Justina Estuar, Timothy Robin Y. Teng, Law Kian Boon, Kalaiarasu M. Peariasamy, Zhuo-Lin Chong, Izzuna Mudla M. Ghazali, Greg J. Fox, Thu-Anh Nguyen, Linh-Vi Le, Milinda Abayawardana B. Eng, David Shipman, Emma S. Mcbryde, Michael T. Meehan, Jamie M. Caldwell, James M. Trauer

Mathematics Faculty Publications

Mathematical models that capture COVID-19 dynamics have supported public health responses and policy development since the beginning of the pandemic, yet there is limited discourse to describe features of an optimal modelling platform to support policy decisions or how modellers and policy makers have engaged with each other. Here, we outline how we used a modelling software platform to support public health decision making for the COVID-19 response in the Western Pacific Region (WPR) countries of the Philippines, Malaysia and Viet Nam. This perspective describes an approach to support evidence-based public health decisions and policy, which may help inform other …

Global Cities And Covid-19: Stories Of Resilience And Fragility In Los Angeles, Edward J.W. Park

Asian and Asian American Studies Faculty Works

This paper examines the impact of the COVID-19 pandemic on global cities. In particular, the paper revisits and updates the academic literature on global cities and focuses on the discussion of the resilience and fragility of global cities in light of an unprecedented global pandemic. By severely testing the strength and durability of the international flow of goods and people, the sweeping scale and intensity of the COVID-19 pandemic directly called into question the thick and complicated network of global cities that serve as modes for international trade and travel. The paper then draws on the impact of COVID-19 on …

Worker Experience A Year Into Covid: Job Demands And Resources In The Philippines, Emerald Jay D. Ilac, Jaimee Felice Caringal-Go, Ma Tonirose De Guzman Mactal, Mendiola Teng-Calleja

Psychology Department Faculty Publications

This study aimed to examine the positive and negative job characteristics that impact employees’ working experience in a country located in the Global South during the COVID-19 pandemic using the job demands and resources (JDR) theory as a framework. Data collection happened approximately one year after the onset of the COVID-19 pandemic in the Philippines. Data came from a qualitative online survey of 122 workers which was then subjected to thematic analysis. For both demands and resources, four superordinate themes emerged: intrapersonal, interpersonal, work or task-related, and organization- related. Intrapersonal job demands included health and safety, and the complexity of …

Uv-Incorporated Sanitation Lining For Disinfection Of Carpentry Tools In Grade Schools, Nicole Dembiczak, Alex Paxitzis, Quinn Piorkowski, Ivana Shah

Williams Honors College, Honors Research Projects

This project will focus on the issues caused by a pandemic, particularly, sanitation issues and difficulties in a public area. After a considerable amount of research, it became evident that current sanitation methods are time inefficient, not always effective and wasteful. There are numerous misconceptions on how these methods work and skepticism of the products themselves. The pandemic caused by COVID-19 is an extremely relevant issue that has affected schools, hospitals and other high traffic areas. This project will focus on K-12 grade schools that struggle with quick, easy and effective cleaning methods in between and after class. We aim …

Impact Of Covid-19 On Students And Faculty In Higher Education, Joshua Manio, Kirsten Bas, Megan Griffith, Sophia Mendoza, Christian Jiao

Occupational Therapy | MSOT Capstone Projects

On March 11th, 2020, the World Health Organization (WHO) officially announced that COVID-19 was a “pandemic” (Kapasia et al., 2020). The impact of COVID-19 on higher education has been substantial. Teaching has changed from traditional in-person, classroom formats to distance learning platforms. As students experienced unprecedented disruptions, faculty faced challenges to provide high-quality teaching and build learning communities with their students. Preliminary global research on the COVID-19 impact on higher education has revealed mental health implications including anxiety and depression (Cao et al., 2020). Additionally, the transition to distance learning has hindered college students’ motivation, academic performance, and educational plans. …

Disparities In Demand For Covid-19 Hospital Care In The United States: Insights From A Longitudinal Hierarchical Study, Wolfgang Messner

Faculty Publications

Background and aims

This study examined disparities in hospitalization for COVID-19 within the U.S. by racial and ethnic groups, health insurance status, and social support structure.

Methods

Using publicly available ecological case and contextual data from July 2020 to April 2021, a longitudinal hierarchical model for the 51 U.S. states was constructed.

Results

Racial/ethnic disparities were observed, such as that hospitalization rates were higher in states with a higher percentage of Black (β = .002, P = .009) and American Indian or Alaska Native persons (β = .003, P = .03). Conversely, lack of health insurance was related …

Creating A Pre-Illness Covid-19 Action Plan: A Web-Based Public Education Initiative, Brian S. Hustad

DNP Research Projects

Abstract

Background: The COVID-19 pandemic took the world by storm in the beginning stages of 2020. Public health agencies were overwhelmed, undermanned, and therefore slow to respond. Information began to flow at an unprecedented rate. Yet, very limited resources were put into place to present this information or to instruct the public on evidence-based prevention, treatment, or care at home during active infection.

Intervention: A project website was created and accessed through a QR code on the project flyer or by entering the URL into any browser. Participants were able to access three evidence- based video modules, which introduced the …

Impact Of The Covid-19 Pandemic On Child Anxiety Symptoms: The Influence Of The Caregiver-Child Relationship, Rebecca Hoppe

Theses and Dissertations

Research suggests that youth are dealing with a myriad of worries during the COVID-19 pandemic (Ellis et al., 2020), which highlights the need for investigations focused on child anxiety. However, to date little research has examined children’s anxiety in the COVID-19 pandemic nor the potential protective effects of the caregiver-child relationship. Therefore, this research aimed to contribute to the literature by investigating the influence of COVID-19 related stressors in younger children and leveraging children’s report of their own attachment security within their relationship with their caregiver and mental health. The current study used a national, quantitative survey of young children …

Did The Political Climate Exacerbate The Pandemic In The U.S.?, Brittany T. Morin, Joanna Gyory, Anthony F. Morin

Master's Theses and Capstones

The global pandemic that began in the United States in early 2020 continues to be a topic of controversy. The added aspect of affect polarization in the country’s political realm may have exacerbated the effects of COVID-19. In their published article in Nature Human Behaviour, Gollwitzer et. al. found that it was possible to link voting partisanship, physical distancing, and COVID-19 outcomes showing that a county’s partisanship might be used to predict the degree to which that county would socially distance and then, therefore, the rate of cases and fatalities in that error on a lagged timescale. This researcher attempted …

Social Media Use And Loneliness During The Covid-19 Pandemic, Katelyn Hughes

College of Graduate Studies: Theses & Dissertations

Social media has played a prominent role in society as a safe way of communicating and connecting with friends, family, and others during the time of the COVID-19 pandemic of 2020. This study examined the general use of social media over the time of the COVID-19 pandemic and correlations with levels of loneliness, depression, anxiety, and stress in comparison to how people felt about their social media use before the pandemic. This study collected self-reported introspection on social media use during the pandemic and before the pandemic from Georgia Southern University students to compare if there are less feelings of …

Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli

Turkish Journal of Biology

Coronavirus disease 2019 (COVID-19) pandemic has been an important global interest that affected millions of people, and it requires a deep investigation of the disease immunology for developing further therapeutic applications. Adoptive T cell therapy promises to address T cell-dependent immune dysregulation in COVID-19 patients by the generation of specific T cell clones against virus-specific antigens. Additionally, targeting B cell-dependent protection through COVID-19 vaccines, which have been developed in the recent year, possessed sufficient prevention for spreading the virus, since the cases and deaths related to COVID-19 tend to decrease after the vaccination. However, adoptive cell therapies are now encouraging …

Covid-19 Vaccine Related Anxiety Partially Mediates The Association Between Covid-19 Related Anxiety And Student Adjustment To College During The Pandemic, Hanh Nguyen

Dissertations and Theses

The COVID-19 pandemic caused severe disruptions to the education of millions of college students, who were forced to adapt to sudden changes in living and learning environments. In this study, we sought to investigate two different dimensions of anxiety that were specific to the pandemic – COVID-19 related anxiety and COVID-19 vaccine anxiety – hoping to pinpoint the relationship between these two variables and students’ ability to adapt to college. Specifically, using cross sectional survey data during three semester waves (Spring 2021, Fall 2021, and Spring 2022) we hypothesized (1) a decreasing trend across time in both COVID-19 related anxiety …

Youtube, Cyberbullying And Covid-19, Ani Shavliashvili

Dissertations and Theses

The purpose of this research is to uncover how people discuss bullying or cyberbullying experiences via YouTube videos before and after the start of the COVID-19 pandemic. Since people were indoors during the pandemic, individuals took to social media and left comments on YouTube about bullying. Since people could not discuss bullying in-person, it was interesting to see how people shared their views on bullying and cyberbullying via YouTube, as well as how that might have changed after the start of COVID-19. The purpose of this study is to demonstrate how social media platforms like YouTube provide a safe space …

Impact Of Covid-19 On Aviation-Wildlife Strikes Across Europe, Isabel C. Metz, Marta Giordano, Dionysios Ntampakis, Marianna Moira, Anneke Hamann, Rosanne Blijleven, Jürgen J. Ebert, Alessandro Montemaggiori

Human–Wildlife Interactions

Collisions between aircraft and wildlife (i.e., wildlife strikes) pose a serious threat toward the safety of aircraft, its crew, and passengers. The effects of COVID-19 related travel restrictions on wildlife strikes are unknown. With this study, we aim to address this information gap by assessing the changes of wildlife hazard management performance across European airports during the lockdown period (e.g., period of reduced operations and borders closure in spring 2020). We also sought to raise awareness of the importance of wildlife strike prevention in times of reduced operations. The objective of our study was to compare wildlife strike data before …

Intergenerational Transmission Of Alexithymia As A Predictor Of Child Posttraumatic Stress Outcomes During Covid-19, Casey Burton

Theses and Dissertations

The objective of this study was to test the role of parent alexithymia in explaining why some children are functioning relatively well during the COVID-19 pandemic while others are experiencing poor mental health. Participants were 88 U.S. children (M_age = 9.94 years; 54.5% female; 59.1% White) and their parents/caregivers (68.2% female; 59.1% White). Two models were tested: a path model in which the association between parent alexithymia symptoms and child COVID-19-related posttraumatic stress symptoms (PTSS) was mediated by child alexithymia symptoms, and a moderator model in which the association between parent alexithymia symptoms and child PTSS was moderated …