Digital Commons Network^™

Covid-19 Pandemic And Recovery Experiences: A Case Study With Montana Family And Consumer Science Cooperative Extension Agents, Hayley M. Somerfeld, J. Mitchell Vaterlaus, Nicole C. Wanago, Brianna Routh, Alison Brennan

Journal of Human Sciences and Extension

The present study examined the impact of COVID-19 and recovery experiences among Family Consumer Science (FCS) Extension Agents in Montana. All participants (n = 10) completed a survey with fixed-item and open-ended responses, and six also participated in in-depth interviews. A deductive qualitative case study approach was used. Agent experiences were analyzed using The Sendai Framework for Disaster Risk Reduction (SFDRR) four action priorities: (1) understanding risk, (2) strengthening disaster risk governance, (3) investing in disaster risk reduction for resilience, and (4) enhancing disaster preparedness for effective response and to “build back better” in recovery, rehabilitation, and reconstruction. Pandemic risks …

Covid-19 Pandemic Impacts On Behavioral And Emotional Health Of Young Children With Autism., Olivia M. Pokoski, Hayley M. Crain, Sarah M. Furnier, Ronald E. Gangnon, Cy Nadler, Eric J. Moody, Karen Pazol, Maria A. Stanley, Lisa D. Wiggins, Maureen S. Durkin

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To test initial hypotheses that the coronavirus disease 2019 (COVID-19) pandemic was associated with decreases in adaptive behavior and increases in behavioral and emotional problems of children with autism; greater impacts for children who lost specialty services; and greater behavioral and emotional problems for children with autism vs control participants.

METHOD: Eligible participants (N = 1,158) enrolled in phase 3 of the multisite, case-control Study to Explore Early Development (SEED) before March 31, 2020, were between 2 and 5 years old, and completed follow-up assessments between January and July 2021. Caregivers completed a COVID-19 Impact Assessment Questionnaire, Vineland Adaptive …

The Burden Of Burnout: Understanding Its Prevalence And Organizational Drivers In Medical Physics, Deborah Schofield, C Lynn Chevalier, Laurence Court, William Harmsen, Akiva Turner

Faculty, Staff and Student Publications

Background: Burnout is a work-related syndrome characterized by increased levels of emotional exhaustion (EE) and depersonalization (DP) along with decreased levels of personal achievement. In the healthcare setting, higher burnout levels have been associated with negative impacts on personnel, an increased risk of errors, and a decrease in the quality of delivered care.

Purpose: The purpose of this study was to assess the prevalence of burnout among medical physicists working in the United States. Additionally, the impact of personal and organizational features on burnout risk was examined.

Methods: The anonymous survey was distributed to 1962 full members of the American …

A Virtual Wellness Program To Enhance Well-Being For Pediatric Oncology Staff During The Covid-19 Pandemic, Karen M Moody, Maria Chang Swartz, Zachary Gresham, Martha Askins, Laura Cahalan, Christine Geistkemper, Amy Heaton, Ruitao Lin, Melissa Melo, Alakh Rajan, Madeline Smith, Priti Tewari, Keyana Williams, Cheng-Han Yang, Rhonda Robert

Faculty, Staff and Student Publications

In response to the COVID-19 global health crisis and mandated social isolation, Pediatric leadership at MD Anderson Children's Cancer Hospital was concerned for the psychological impact on its workforce and encouraged wellness programming. A grassroots wellness taskforce was assembled for the Division of Pediatrics. The task force's primary mission was to promote the well-being of clinicians and non-clinical staff members through a broadly accessible, sustainable, and effective virtual wellness program. Guided by the Stanford Model for Professional Fulfillment, a virtual program entitled, "Weekly Wellness Webex" for Pediatrics staff was launched. Weekly Wellness Webex is a 1-hour live-streamed program with varied …

Alterations In Gut Microbiome Composition And Increased Inflammatory Markers In Post-Covid-19 Individuals, Tatiana Barichello, Bruno Kluwe-Schiavon, Laura A Borba, Lucas C Pedro, Flávia S Niero, Laísa N Dos Santos, Letícia M Leonardo, Zuleide M Ignácio, Rodrigo Morales, Luciane B Ceretta, Gislaine Z Reus

Faculty, Staff and Student Publications

Dysfunctions in the immune system and alterations in the microbiome composition following SARS-CoV-2 infection contribute to persistent neurological issues observed in long COVID-19 survivors. We hypothesize that alterations in the gut microbiome composition and peripheral inflammatory profile following COVID-19 may play pivotal roles in behavior changes among individuals experiencing long-term illness. This cross-sectional study included a sample of post-COVID-19 and non-COVID-19 subjects. We assessed the presence of psychiatric conditions utilizing standardized diagnostic criteria, Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression (HAM-D), Biological Rhythms in Neuropsychiatry Assessment Interview (BRIAN), and Functional Assessment Short Test (FAST). Plasma samples …

Predictors Of Nursing Students' Stress, Anxiety, And Depression During The Covid-19 Pandemic In A Hispanic-Serving University In South Texas: A Cross-Sectional Study, Maria I. Diaz, Eleftherios Gkioulekas, Nancy Nadeau

School of Mathematical & Statistical Sciences Faculty Publications

Background: In nursing education, there have been several studies on the impact of the COVID-19 pandemic on the ability of nursing students to cope while in nursing school.

Purpose statement: The goal of this study is to assess undergraduate nursing students' support mechanisms as predictors of stress, anxiety, and depression during the COVID-19 pandemic within a Hispanic-serving institution in South Texas.

Methods: Across-sectional design was used in this study. An online survey using self-reported questionnaires was used to gather data from an undergraduate nursing student cohort during the Fall 2021 semester. Linear regression was used to identify the predictors of …

Hand Hygiene Roles, Challenges, And Intervention Feedback From School Staff: A Qualitative Analysis, Belize, 2022-2023, Anh N Ly, Christina Craig, Dian Maheia, Yolanda Gongora, Vickie Romero, Rosalva Blanco, Allison Lino, Kelsey Mcdavid, Allison Stewart, Victoria Trinies, Alexandra Medley, Francis Morey, Russell Manzanero, Matthew Lozier, Kristy O Murray

Faculty, Staff and Students Publications

Hand hygiene (HH) in school settings can reduce the spread of infectious diseases and student absenteeism due to illness. During the COVID-19 pandemic, the World Health Organization recommended HH as a public health measure to prevent disease transmission. Understanding school staff's experiences with school-based programs is important for future program development and improvement. As part of a mixed-methods study, we conducted in-depth interviews in March 2022 with school administrators and teachers at 12 primary schools in Belize, selected based on high gaps in HH resources, to understand HH responsibilities, supplies, and challenges. An intervention was implemented to increase HH knowledge …

Family Mealtime Experience Of Traditional Fathers Post-Covid-19 Pandemic: A Qualitative Study, Eric C. Tibbs

Doctoral Dissertations and Projects

In 2020, COVID-19 impacted the world and transformed the way individuals and families operated and functioned daily. Lockdowns and restrictions forced families to stay home and find alternative ways of providing and living concerning employment, education, and family functioning. One particular area impacted by this phenomenon was how families operated and conducted family meals. During COVID-19, increases in family mealtime were seen to take place but little evidence was found regarding the quality of these mealtimes, the father’s experience, and what family functioning looked like after COVID-19. While family functioning and mealtimes during COVID-19 have been examined and analyzed over …

Seeing Resilience Through Experience: Teachers' Resilience Experiences Post Covid-19 Pandemic, Yashica Dudley

Doctoral Dissertations and Projects

The purpose of this phenomenological was to describe the post-COVID-19 resilience experiences of 6th to 12th grade schoolteachers at Hope County Public School (HCPS). The theory that guided this study is the differing pathways to resiliency theory, as it was used to describe teachers’ resilience experiences regarding the outlook on work, self-efficacy, and coping responses. The central research question was, “What are the post-COVID-19 resilience experiences of 6th to 12th grade schoolteachers at the HCPS in the classroom?” Participants included 10-15 6th to 12th grade schoolteachers who taught before, during, and post the COVID-19 pandemic. The data was collected through …

Exploring The Challenges And Resilience Of Licensed Black Female Counselors In Texas During The Covid-19 Pandemic And George Floyd Era: A Phenomenological Study, Krissandra C. Haynes

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the licensed Black female counselors (LBFCs) that provided mental health services during the COVID-19 pandemic and George Floyd era. This study was guided by Schlossberg’s transition theory to examine how LBFCs navigated professional and personal transitions during a time marked by collective trauma, public health disparities, and heightened racial tension. Participants described this time of counseling clients through parallel experiences of grief and social unrest while also tending to their wellness. Core themes included the duality of the healer role, significance of spiritual and faith-based coping, influence of social activism, …

Effects Of Covid-19 On Special Education Teachers In Calvert County, Maryland, Jody L. Scott

Doctoral Dissertations and Projects

The purpose of this phenomenological research was to understand and describe the lived experiences and impact of the COVID-19 global pandemic and the subsequent traumas on Special Education teachers in Calvert County, Maryland. It is rooted in axiological assumptions and guided by social constructivism and transition theory. Transition theory, as posited by Nancy K. Schlossberg, relates to the cycle of change in each educator using the “Four Ss” in the transition process: Self, Situation, Support, and Strategies. Special Education teachers took part in a Conceptual Mapping Task to express lived experiences during and after the pandemic. The activity aided each …

Teacher Perspective And De-Escalation Of Aggressive And Disruptive Behaviors In Early Elementary Students Who Come To School At Risk Of Academic Failure: A Phenomenological Study, Rebecca L. Thurman

Doctoral Dissertations and Projects

The purpose of this qualitative, hermeneutic phenomenological research study was to understand the experiences of early elementary educators with the rising negative behaviors, such as aggression and classroom disruptions, in their current classrooms within a progressive and growing school district in northwest Georgia. The theory that guided this study was Bandura’s social learning theory. This study addressed the question: How do educators perceive, understand possible causes, and utilize research-based programs and strategies to de-escalate and improve students’ aggressive and disruptive behaviors in the elementary classroom? This study focused on individual and focus group interviews, as well as a teacher behavior …

Impact Of Nursing Home Staff Hours And Administrator Turnover On Quality Of Care Post-Covid-19 Pandemic In Texas, Kendra King

Walden Dissertations and Doctoral Studies

Nursing facilities experienced heightened unfavorable outcomes related to quality of care and staffing patterns during the COVID-19 pandemic. The purpose of this quantitative, quasi-experimental, retrospective study was to determine if there was a relationship between nursing home administrator turnover, total nurse staffing (i.e., LPN, RN, and nurse aides) hours per resident per day, and the quality of care as measured by the Long Stay Quality Measure (LSQM) rating in Texas after the COVID-19 pandemic in 2023. The Donabedian model, using the elements of structure, process, and outcomes, served as the theoretical framework for this study. Structure was represented by the …

Turning Analysis Into Action: Opportunities And Challenges In Implementing Wastewater Science For Public Health Decision-Making, Anna Gitter, Valeria Ruvalcaba, Katelyn Clark, Theresa Tran Carapucci, Fuqing Wu, Blake M Hanson, Jennifer Deegan, John Balliew, Eric Boerwinkle, Anthony W Maresso, Kristina D Mena

Faculty, Staff and Students Publications

In the 5 years since the emergence of the COVID-19 pandemic, the field of wastewater-based epidemiology (WBE) has dramatically expanded with programs implemented across the globe to monitor for SARS-CoV-2 and other viruses of public health concern. However, the best way to use wastewater surveillance data and inform local communities of the utility of wastewater science remains limited and sporadically discussed. Specifically, there is vague guidance regarding interpreting varying levels of viral loads in wastewater for public health significance. While collaborative efforts are key to implementing these community-specific wastewater surveillance programs, effectively using the data for public health decision-making still …

Histone Methyltransferase Ash1l Primes Metastases And Metabolic Reprogramming Of Macrophages In The Bone Niche, Chenling Meng, Kevin Lin, Wei Shi, Hongqi Teng, Xinhai Wan, Anna Debruine, Yin Wang, Xin Liang, Javier Leo, Feiyu Chen, Qianlin Gu, Jie Zhang, Vivien Van, Kiersten L Maldonado, Boyi Gan, Li Ma, Yue Lu, Di Zhao

Faculty, Staff and Student Publications

Bone metastasis is a major cause of cancer death; however, the epigenetic determinants driving this process remain elusive. Here, we report that histone methyltransferase ASH1L is genetically amplified and is required for bone metastasis in men with prostate cancer. ASH1L rewires histone methylations and cooperates with HIF-1α to induce pro-metastatic transcriptome in invading cancer cells, resulting in monocyte differentiation into lipid-associated macrophage (LA-TAM) and enhancing their pro-tumoral phenotype in the metastatic bone niche. We identified IGF-2 as a direct target of ASH1L/HIF-1α and mediates LA-TAMs' differentiation and phenotypic changes by reprogramming oxidative phosphorylation. Pharmacologic inhibition of the ASH1L-HIF-1α-macrophages axis elicits …

Leading Through Crisis: San Diego County Schools' Response To The Social Emotional Needs Of All Students, Johana Bielma

Dissertations

The COVID-19 pandemic led to unprecedented school closures, forcing administrators to take decisive action to radically change the educational system. The imperative to switch to remote learning transformed the dynamics of teaching and learning, leading to both immediate and long-term academic and social emotional consequences for all stakeholders. When schools reopened, administrators faced the challenge of reintegrating students into in-person learning while addressing the pandemic’s lasting effects on academics, mental health, and school safety. While academic regression was evident, the extent of students’ emotional struggles was less anticipated. Many students exhibited increased irritability and mental health issues such as depression …

Shifting To A Culture Of Inclusion By Design: Applying A Mixed-Methods Approach To Advance Accessibility Of Public Health Emergency Information & Communication Technology, Jessica L. Franks, Erin Vinoski Thomas

Developmental Disabilities Network Journal

Adults with intellectual and developmental disabilities (IDD) experience inequities in access to timely, accurate, and understandable information and communication technology (ICT), which increases risk for public health emergency (PHE)-related health disparities and impedes opportunities to achieve optimal health. This study assessed federal COVID-19 webpage accessibility levels and explored existing knowledge of and experience with filing accessibility complaints for federal ICT among adults with IDD. Through a mixed-methods approach, we evaluated compliance with accessibility standards for 18 federal agencies’ COVID-19 webpages (study 1) and interviewed 16 adults with IDD about experiences accessing federal webpages and filing accessibility complaints (study 2). We …

Sars-Cov-2 Induced Immune Perturbations In Infants Vary With Disease Severity And Differ From Adults' Responses., Djamel Nehar-Belaid, Asunción Mejías, Zhaohui Xu, Radu Marches, Rushil Yerrabelli, Guo Chen, Sara Mertz, Fang Ye, Pablo J Sánchez, John S Tsang, Teresa Aydillo, Lisa Miorin, Anastasija Cupic, Adolfo García-Sastre, Duygu Ucar, Jacques Banchereau, Virginia Pascual, Octavio Ramilo

Faculty Research 2025

Differences in immune profiles of children and adults with COVID-19 have been previously described. However, no systematic studies have been reported from infants hospitalized with severe disease. We applied a multidimensional approach to decipher the immune responses of SARS-CoV-2 infected infants (n = 26; 10 subacute, 11 moderate and 5 severe disease; median age = 1.6 months) and matched controls (n = 14; median age = 2 months). Single cell (scRNA-seq) profiling of PBMCs revealed substantial alterations in cell composition in SARS-CoV-2 infected infants; with most cell-types switching to an interferon-stimulated gene (ISG^hi) state including: (i) …

Culturally Responsive Social-Emotional Learning Amid And After The Covid-19 Pandemic Among Deaf And Hard Of Hearing Students, Ezra Forero-Tarquino

Undergraduate University Honors Capstones

During and after the COVID-19 pandemic, teachers recognized that online learning stagnated students’ social emotional development (SED). SED is the ability to foster meaningful relationships while also being able to manage, express, and acknowledge emotions, (Office of Head Start, n.d., para.2). SED is typically fostered through in-person interactions, therefore, social-emotional learning (SEL) strategies had to be modified to address online learning. SEL, is the practice of a wide range of skills, attitudes, and behaviors that affect a student’s success in school and life, and is necessary for SED. For example, critical thinking, managing emotions, working through conflicts, decision making, and …

Voices Of Leadership: The Perceptions And Lived Experiences Of Principals Amid The Covid-19 Pandemic, Jeri Johnson

Graduate Theses & Dissertations

The COVID-19 pandemic created a crisis in schools. The purpose of this research is to explore the phenomenon and lived experiences of principals as they led their schools during COVID-19. This qualitative research will explore how principals navigated the complexity of leadership to sustain academic achievement. Principals will share how the three levels of crisis, danger and opportunity created a pathway for principal actions of effectiveness. Additionally, this research explored how principals made sense of the crisis to promote community, collaboration and compassion. Principals were asked to describe their perceptions of leadership and to share their lived experiences from March …

Exploring The Public Health Agency Of Canada’S And The Ontario Government’S Vaccine-Related Crisis Communication On X During The Covid-19 Pandemic, Sheraza Burney, Lori Donelle Phd, Rn, Fcan, Anita Kothari

Publications

Crisis communication strategies must be tailored to the unique nature of social media. In response to the COVID-19 pandemic, public health agencies have widely used social media to address vaccine hesitancy and misinformation. This research utilized the social media pandemic communication model to describe the key themes disseminated through the Ontario government and the Public Health Agency of Canada's vaccine-related crisis communication on X (formerly Twitter). Between 27 January 2020 and 6 April 2021, 1271 posts related to COVID-19 vaccination were collected from three official government X accounts—two from the province of Ontario and one from Canada. Posts were analyzed …

Covid-19 And Related Adverse Neurological Complications, Hannah A. Wasson

Honors Thesis

Abstract

The COVID-19 pandemic changed the world drastically, and its impact was monumental. COVID-19 or SARS-CoV-2, or severe acute respiratory syndrome, was the virus responsible for causing such mayhem. This contagious virus can enter the body via different routes, live on surfaces for hours, and be transmitted through the air, increasing infection risk. Once it enters the body, it can trick the body into replicating the virus. From this reaction within the body, signs and symptoms follow. While the name indicates a respiratory illness, the virus can inflict injury on other parts of the body. Due to the organ systems …

A Virtual Wellness Program To Enhance Well-Being For Pediatric Oncology Staff During The Covid-19 Pandemic, Karen Moody, Maria Swartz, Zachary Gresham, Martha Askins, Laura Cahalan, Pavilia Francis, Christine Geistkemper, Amy Heaton, Ruitao Lin, Melissa Melo, Alakh Rajan, Madeline Smith, Priti Tewari, Keyana R. Williams, Cheng-Han Yang, Rhonda Robert

Advances in Cancer Education and Quality Improvement

In response to the COVID-19 global health crisis and mandated social isolation, Pediatric leadership at MD Anderson Children’s Cancer Hospital was concerned for the psychological impact on its workforce and encouraged wellness programming. A grassroots wellness taskforce was assembled for the Division of Pediatrics. The task force’s primary mission was to promote the well-being of clinicians and non-clinical staff members through a broadly accessible, sustainable, and effective virtual wellness program. Guided by the Stanford Model for Professional Fulfillment, a virtual program entitled, “Weekly Wellness Webex” for Pediatrics staff was launched. Weekly Wellness Webex is a 1-hour live-streamed program with varied …

Lived Experiences Of Icu Nurses Caring For Critically Ill Patients Infected With Covid-19: A Phenomenological Study In Thailand, Charuedee Putruttanamaneekun, Yaowarat Matchim, Thitiporn Pathomjaruwat, Thanyarat Boontoi, Itsari Srisupha-Olarn, Sukanya Thongbupa, Borwarnluck Thongthawee, Parinya Raetong

Journal of Health Research

Background: COVID-19 is an emerging disease that caused infections and a pandemic worldwide. Intensive care unit (ICU) nurses played an important role in providing care for critically ill patients. Their experiences during the pandemic in Thailand were not well documented. This study explored the lived experiences of ICU nurses caring for critically ill patients infected with COVID-19 in Thailand.

Methods: We conducted a qualitative, phenomenological study guided by Gadamer’s philosophical hermeneutics. Data were collected between December 2021 and March 2023 among fifteen ICU nurses at a university hospital. The partcipants drew pictures reflecting their experiences; they participated in in-depth interviews …

Elementary School Counselors Perceived Barriers To Service Delivery Throughout The Covid-19 Pandemic, Kimberly L. Johnson

Walden Dissertations and Doctoral Studies

Elementary school counselors are essential to shaping the foundation of academic, social, and emotional development of children which was negatively impacted by the COVID-19 pandemic. ESCs were required to maintain the same level of engagement despite the pressing circumstances. No one has explored the lived experiences of ESCs as they faced extreme barriers and without this study, stakeholders would be ill-equipped to address their needs. The purpose of this descriptive phenomenological study was to explore ESCs perceived barriers to comprehensive service delivery during the COVID-19 pandemic. Husserl’s descriptive phenomenological research approaches were used, including only ESCs who worked throughout the …

Parental Vaccine Hesitancy And The Decision To Vaccinate Children Against Covid-19, Jessica Mckee

Walden Dissertations and Doctoral Studies

While there is a significant body of literature regarding vaccine hesitancy, there is a gap in the literature on its impact to parents’ decisions to vaccinate their children against a pandemic pathogen. The purpose of this study was to examine the relationship between parental vaccine hesitancy, measured using the health belief model (HBM) theoretical framework constructs of the Vaccine Hesitancy Scale (VHS; the degree to which an individual trusts in vaccine efficacy, safety, the reliability and trustworthiness of vaccine programs, community impact, perceived risks, and the importance of childhood vaccinations), and parents’ decision to vaccinate their children against COVID-19 with …

Maternal Depression And Covid-19: A Secondary Analysis Comparing Postnatal Depression Rates During And Before The Covid-19 Pandemic, Amanda A. Berney

2025 Spring Honors Capstone Projects - Archive

The COVID-19 pandemic created increased psychological vulnerability across the globe through isolation, fear of infection, and misinformation from various sources, including social media. Women giving birth during the pandemic, therefore, may be extremely vulnerable psychologically. Per the World Health Organization, the years 2020 to mid 2021were designated as an intense time during the COVID-19 pandemic. Thus, the objective of this secondary analysis was to compare depression scores among women giving birth during these intense years and women giving birth before 2020. However, due to a small window of time and sample size, statistical analysis failed to find a correlation between …

Examining The Lasting Impacts Of Covid-19 On College Students And Professors, Honor S. Luna, Alexia Angton

Sociology and Criminology Undergraduate Honors Theses

This study analyzes the impact of COVID-19 on the mental health, academic performance, and socialization of college students, as well as college professors’ perceptions of their own mental health, workload, and observed changes in students. University of Arkansas undergraduate students were surveyed online about their pandemic experiences, and faculty members were interviewed on similar topics. Students reported a noticeable decline in mental health, primarily due to isolation, being confined to their homes, and reduced contact with friends. Faculty faced stress from the rapid shift to virtual learning, decreased student engagement, and the challenge of balancing work and family while maintaining …

Student Perceptions Of School Climate And Safety After The Collective Trauma Of Covid-19 And Racial Injustice Syndemic., Amy Catherine Lyons

Electronic Theses and Dissertations

For people in marginalized communities, particularly the Black and African American community, the combined, disproportionate damage and loss from of the pandemic and a cacophony of racial injustices offer cause for labeling the phenomenon a syndemic. Syndemic is defined as “a conceptual framework for understanding diseases or health conditions that arise in populations and that are exacerbated by the social, economic, environmental, and political milieu in which a population is immersed” (Singer et al., 2017, p. 881). The purpose of this study is to explore, describe, and analyze Kentucky students’ perceptions of school climate and safety by demographic groups, racial …

An Intranasal Subunit Vaccine Induces Protective Systemic And Mucosal Antibody Immunity Against Respiratory Viruses In Mouse Models., Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C Moe, Benjamin E. Low, Michael V. Wiles, David Nemazee, Frode L Jahnsen, John Torgils Vaage, Kenneth A Howard, Inger Sandlie, Leo C James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen

Faculty Research 2025

Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge, however, is to achieve delivery across the selective epithelial cell barrier. Here we report on a subunit vaccine platform, in which the antigen is genetically fused to albumin to facilitate FcRn-mediated transport across the mucosal barrier in the presence of adjuvant. Intranasal delivery in conventional and transgenic mouse models induces both systemic and mucosal antigen-specific antibody responses that protect against challenge with SARS-CoV-2 or influenza A. When benchmarked …