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"Mining" For A Reference Condition In Southern West Virginia Streams, Matthew Rouch Jan 2014

"Mining" For A Reference Condition In Southern West Virginia Streams, Matthew Rouch

Theses and Dissertations

Quarterly samples were used to estimate assemblage-level (all species combined) fish production within three minimally-impacted, southern West Virginia streams. The total annual fish production estimate was highest in Slaunch Fork (37.52 kg∙ha-1∙y-1), a tributary of the Tug Fork River, and lowest in Cabin Creek (10.59 kg∙ha-1∙y-1), a Guyandotte River tributary. Creek Chub Semotilus atromaculatus, Mottled Sculpin Cottus bairdii and Blacknose Dace Rhinicthys atratulus were the most abundant species among sites, accounting for >90% of all sampled individuals. Reference condition criteria were also selected and metrics calculated for each of the three …

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A Not-So-Silent Spring: The Impacts Of Traffic Noise On Call Features Of The Bloody Bay Poison Frog (Mannophryne Olmonae), Catherine G. Clemmens Jan 2014

A Not-So-Silent Spring: The Impacts Of Traffic Noise On Call Features Of The Bloody Bay Poison Frog (Mannophryne Olmonae), Catherine G. Clemmens

Senior Independent Study Theses

No abstract provided.

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Using Quantitative Genetics Methods To Estimate Heritability Of Larval Co2-Resistance In A Coastal Marine Fish, Alex James Malvezzi Dec 2013

Using Quantitative Genetics Methods To Estimate Heritability Of Larval Co2-Resistance In A Coastal Marine Fish, Alex James Malvezzi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Marine organisms are under pressure to adapt to anthropogenic changes that are rapidly altering ocean water chemistry. Since the Industrial Revolution, human activities have caused an increase in atmospheric CO2 which is partly absorbed by the world's oceans, thereby reducing ocean pH, aragonite and calcite saturation states in a process known as ocean acidification (OA). Concern over these changes has caused a surge in scientific interest to better understand and predict how OA affects marine organisms from single celled algae to marine calcifying invertebrates and vertebrates such as fish. Since most studies thus far have focused on short-term responses of …

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Using Quantitative Genetics Methods To Estimate Heritability Of Larval Co2-Resistance In A Coastal Marine Fish, Alex James Malvezzi Dec 2013

Using Quantitative Genetics Methods To Estimate Heritability Of Larval Co2-Resistance In A Coastal Marine Fish, Alex James Malvezzi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Marine organisms are under pressure to adapt to anthropogenic changes that are rapidly altering ocean water chemistry. Since the Industrial Revolution, human activities have caused an increase in atmospheric CO2 which is partly absorbed by the world's oceans, thereby reducing ocean pH, aragonite and calcite saturation states in a process known as ocean acidification (OA). Concern over these changes has caused a surge in scientific interest to better understand and predict how OA affects marine organisms from single celled algae to marine calcifying invertebrates and vertebrates such as fish. Since most studies thus far have focused on short-term responses of …

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Using Quantitative Genetics Methods To Estimate Heritability Of Larval Co2-Resistance In A Coastal Marine Fish, Alex James Malvezzi Dec 2013

Using Quantitative Genetics Methods To Estimate Heritability Of Larval Co2-Resistance In A Coastal Marine Fish, Alex James Malvezzi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Marine organisms are under pressure to adapt to anthropogenic changes that are rapidly altering ocean water chemistry. Since the Industrial Revolution, human activities have caused an increase in atmospheric CO2 which is partly absorbed by the world's oceans, thereby reducing ocean pH, aragonite and calcite saturation states in a process known as ocean acidification (OA). Concern over these changes has caused a surge in scientific interest to better understand and predict how OA affects marine organisms from single celled algae to marine calcifying invertebrates and vertebrates such as fish. Since most studies thus far have focused on short-term responses of …

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Lack Of Csk-Mediated Negative Regulation In A Unicellular Src Kinase, Kira Schultheiss Dec 2013

Lack Of Csk-Mediated Negative Regulation In A Unicellular Src Kinase, Kira Schultheiss

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Tyrosine kinases play important roles in cellular communication in animals. c-Src is a nonreceptor tyrosine kinase that is involved in survival, angiogenesis, proliferation, and invasion pathways. There are 9 Src family kinases, and they have a conserved domain arrangement (SH3-SH2-kinase) that is necessary for regulation. The basal activity of c-Src is normally kept low due to phosphorylation by C-terminal Src kinase (Csk). This regulatory relationship has been conserved throughout the evolution of animals. Until recently, it was thought that complex signaling molecules, such as the tyrosine kinases, did not exist outside of multicellular animals. Newly discovered unicellular precursors to mammalian …

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Mechanisms For Regulation Of Plant Kinesins, Anindya Ganguly, Ram Dixit Dec 2013

Mechanisms For Regulation Of Plant Kinesins, Anindya Ganguly, Ram Dixit

Biology Faculty Research

Throughout the eukaryotic world, kinesins serve as molecular motors for the directional transport of cellular cargo along microtubule tracks. Plants contain a large number of kinesins that have conserved as well as specialized functions. These functions depend on mechanisms that regulate when, where and what kinesins transport. In this review, we highlight recent studies that have revealed conserved modes of regulation between plant kinesins and their non-photosynthetic counterparts. These findings lay the groundwork for understanding how plant kinesins are differentially engaged in various cellular processes that underlie plant growth and development.

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A Seasonal, Density-Dependent Model For The Management Of An Invasive Weed, Esther Shyu, Eleanor A. Pardini, Tiffany M. Knight, Hal Caswell Dec 2013

A Seasonal, Density-Dependent Model For The Management Of An Invasive Weed, Esther Shyu, Eleanor A. Pardini, Tiffany M. Knight, Hal Caswell

Biology Faculty Research

The population effects of harvest depend on complex interactions between density dependence, seasonality, stage structure, and management timing. Here we present a periodic nonlinear matrix population model that incorporates seasonal density dependence with stage-selective and seasonally selective harvest. To this model, we apply newly developed perturbation analyses to determine how population densities respond to changes in harvest and demographic parameters. We use the model to examine the effects of popular control strategies and demographic perturbations on the invasive weed garlic mustard (Alliaria petiolata). We find that seasonality is a major factor in harvest outcomes, because population dynamics may …

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Distribution And Abundance Of Anopheles Spp. In The Lower Rio Grande Valley, South Texas, Norma Hermelinda Martinez Dec 2013

Distribution And Abundance Of Anopheles Spp. In The Lower Rio Grande Valley, South Texas, Norma Hermelinda Martinez

Theses and Dissertations - UTB/UTPA

This study investigated the relationship between Anopheles abundance, collection sites and environmental variables in the Lower Rio Grande Valley, South Texas. In addition, species composition in the Lower Rio Grande Valley was determined in 2011. A total of 6772 female mosquitoes were identified to six genera and 27 species. The most prevalent genera collected were Culex (53.9%), Ochlerotatus (25.6%) and Aedes (13.6%). Anopheles mosquitoes were collected using resting boxes during summer 2012 at multiple locations along the Lower Rio Grande Valley. ArcGIS was used to identify land cover characteristics and nearest water sources at mosquito collection sites. Estero Llano Grande …

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Microbial Genome Evolution Due To Multifaceted Symbiosis Within The Tsetse Fly (Diptera: Glossinidae), Anna Kathleen Snyder Dec 2013

Microbial Genome Evolution Due To Multifaceted Symbiosis Within The Tsetse Fly (Diptera: Glossinidae), Anna Kathleen Snyder

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microbes are capable of rapid genetic modification, enabling the habitation of a wide field of niches, including forming interdependent associations with macroscopic hosts. While ancient multipartite mutualisms have been shown to involve metabolic complementation, little is known concerning the early genomic adaptations leading towards co-residence within a novel host. The overall objective of this research is to gain insight on genome evolution resulting from symbiosis, particularly by examining bacteria with varying levels of host dependency and times of establishment. The tsetse fly (Diptera: Glossinidae) serves as a relatively simple model system to investigate evolutionary aspects of symbiosis, while also maintaining …

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Conservation In The Context Of Climate Change: Practical Guidelines For Land Protection At Local Scales, Kevin Ruddock, Peter V. August, Christopher Damon, Charles Labash, Pamela Rubinoff, Donald Robadue Jr. Nov 2013

Conservation In The Context Of Climate Change: Practical Guidelines For Land Protection At Local Scales, Kevin Ruddock, Peter V. August, Christopher Damon, Charles Labash, Pamela Rubinoff, Donald Robadue Jr.

Natural Resources Science Faculty Publications

Climate change will affect the composition of plant and animal communities in many habitats and geographic settings. This presents a dilemma for conservation programs – will the portfolio of protected lands we now have achieve a goal of conserving biodiversity in the future when the ecological communities occurring within them change? Climate change will significantly alter many plant communities, but the geophysical underpinnings of these landscapes, such as landform, elevation, soil, and geological properties, will largely remain the same. Studies show that extant landscapes with a diversity of geophysical characteristics support diverse plant and animal communities. Therefore, geophysically diverse landscapes …

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Life History Comparison Of Two Green Lacewing Species Chrysoperla Johnsoni And Chrysoperla Carnea (Neuroptera: Chrysopidae), Kaushalya G. Amarasekare, Peter W. Shearer Oct 2013

Life History Comparison Of Two Green Lacewing Species Chrysoperla Johnsoni And Chrysoperla Carnea (Neuroptera: Chrysopidae), Kaushalya G. Amarasekare, Peter W. Shearer

Agricultural and Environmental Sciences Faculty Research

We investigated the life histories of two green lacewing species, Chrysoperla johnsoni Henry, Wells, and Pupedis from western North America, and Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae) from western Europe in the laboratory. There were both similarities and differences in their life history characteristics. C. johnsoni exhibited a significantly longer developmental time for egg, first instar, and pupal stage than C. carnea. C. carnea exhibited a significantly shorter egg to adult developmental time than C. johnsoni. Except for the pupal stage, the survival of all other life history stages was not species-specific. All C. carnea pupae were able to develop …

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Lifelines Fall 2013, Southern Adventist University Oct 2013

Lifelines Fall 2013, Southern Adventist University

Lifelines - Biology Department Newsletter

The Fall 2013 issue of Lifelines features articles on toxins found in nature, student missions in Tanzania, an alumni spotlight, undergraduate research, and updates on department happenings.

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"Are We Not Men?" The Effect Of Cloning On Traditional Theories Of Humanity And Personhood, Michelle Kennedy Sep 2013

"Are We Not Men?" The Effect Of Cloning On Traditional Theories Of Humanity And Personhood, Michelle Kennedy

Journal of Franco-Irish Studies

No abstract provided.

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Polydnaviral Ankyrin Proteins Aid Parasitic Wasp Survival By Coordinate And Selective Inhibition Of Hematopoietic And Immune Nf-Kappa B Signaling In Insect Hosts, Gwenaelle Gueguen, Marta E. Kalamarz, Johnny Ramroop, Jeffrey Uribe, Shubha Govind Aug 2013

Polydnaviral Ankyrin Proteins Aid Parasitic Wasp Survival By Coordinate And Selective Inhibition Of Hematopoietic And Immune Nf-Kappa B Signaling In Insect Hosts, Gwenaelle Gueguen, Marta E. Kalamarz, Johnny Ramroop, Jeffrey Uribe, Shubha Govind

Publications and Research

Polydnaviruses are mutualists of their parasitoid wasps and express genes in immune cells of their Lepidopteran hosts. Polydnaviral genomes carry multiple copies of viral ankyrins or vankyrins. Vankyrin proteins are homologous to IκB proteins, but lack sequences for regulated degradation. We tested if Ichnoviral Vankyrins differentially impede Toll-NF-κB-dependent hematopoietic and immune signaling in a heterologous in vivo Drosophila, system. We first show that hematopoiesis and the cellular encapsulation response against parasitoid wasps are tightly-linked via NF-κB signaling. The niche, which neighbors the larval hematopoietic progenitors, responds to parasite infection. Drosophila NF-κB proteins are expressed in the niche, and non cell-autonomously …

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Mscs-Like Mechanosensitive Channels In Plants And Microbes, Margaret E. Wilson, Grigory Maksaev, Elizabeth S. Haswell Aug 2013

Mscs-Like Mechanosensitive Channels In Plants And Microbes, Margaret E. Wilson, Grigory Maksaev, Elizabeth S. Haswell

Biology Faculty Research

The challenge of osmotic stress is something all living organisms must face as a result of environmental dynamics. Over the past three decades, innovative research and cooperation across disciplines have irrefutably established that cells utilize mechanically gated ion channels to release osmolytes and prevent cell lysis during hypoosmotic stress. Early electrophysiological analysis of the inner membrane of Escherichia coli identified the presence of three distinct mechanosensitive activities. The subsequent discoveries of the genes responsible for two of these activities, the mechanosensitive channels of large (MscL) and small (MscS) conductance, led to the identification of two diverse families of mechanosensitive channels. …

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Β-Catenin-Independent Activation Of Tcf1/Lef1 In Human Hematopoietic Tumor Cells Through Interaction With Atf2 Transcription Factors, Luca Grumolato, Guizhong Liu, Tomomi Haremaki, Sathish Kumar Mungamuri, Phyllus Mong, Gal Akiri, Pablo Lopez-Bergami, Adriana Arita, Youssef Anouar, Marek Mlodzik, Ze'ev A. Ronai, Joshua Brody, Daniel C. Weinstein, Stuart A. Aaronson Aug 2013

Β-Catenin-Independent Activation Of Tcf1/Lef1 In Human Hematopoietic Tumor Cells Through Interaction With Atf2 Transcription Factors, Luca Grumolato, Guizhong Liu, Tomomi Haremaki, Sathish Kumar Mungamuri, Phyllus Mong, Gal Akiri, Pablo Lopez-Bergami, Adriana Arita, Youssef Anouar, Marek Mlodzik, Ze'ev A. Ronai, Joshua Brody, Daniel C. Weinstein, Stuart A. Aaronson

Publications and Research

The role of Wnt signaling in embryonic development and stem cell maintenance is well established and aberrations leading to the constitutive up-regulation of this pathway are frequent in several types of human cancers. Upon ligand-mediated activation, Wnt receptors promote the stabilization of β-catenin, which translocates to the nucleus and binds to the T-cell factor/lymphoid enhancer factor (TCF/LEF) family of transcription factors to regulate the expression of Wnt target genes. When not bound to β-catenin, the TCF/LEF proteins are believed to act as transcriptional repressors. Using a specific lentiviral reporter, we identified hematopoietic tumor cells displaying constitutive TCF/LEF transcriptional activation in …

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A Force Of Nature: Molecular Mechanisms Of Mechanoperception In Plants, Gabriele B. Monshausen, Elizabeth S. Haswell Aug 2013

A Force Of Nature: Molecular Mechanisms Of Mechanoperception In Plants, Gabriele B. Monshausen, Elizabeth S. Haswell

Biology Faculty Research

The ability to sense and respond to a wide variety of mechanical stimuli-gravity, touch, osmotic pressure, or the resistance of the cell wall-is a critical feature of every plant cell, whether or not it is specialized for mechanotransduction. Mechanoperceptive events are an essential part of plant life, required for normal growth and development at the cell, tissue, and whole-plant level and for the proper response to an array of biotic and abiotic stresses. One current challenge for plant mechanobiologists is to link these physiological responses to specific mechanoreceptors and signal transduction pathways. Here, we describe recent progress in the identification …

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Interview With Jane West - Oh 274, Martha Jane Cato West Jul 2013

Interview With Jane West - Oh 274, Martha Jane Cato West

Winthrop University Oral History Program

In her July 15, 2013 interview with Martha Manning, Jane Cato West (Class of 1968) details her time at Winthrop as a Biology major in the 1960s. Briefly, West discusses student life and Winthrop traditions, but she provides insight into her life student teaching at Florence High School. Additionally, West includes her experience in required courses like English and Math, as well as experiments conducted in her Biology courses. West concludes the interview with her overall perceptions of Winthrop.

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James’S Rule And Causes And Consequences Of A Latitudinal Cline In The Demography Of John’S Snapper (Lutjanus Johnii) In Coastal Waters Of Australia, Mike Cappo, Ross J. Marriott, Stephen J. Newman Jul 2013

James’S Rule And Causes And Consequences Of A Latitudinal Cline In The Demography Of John’S Snapper (Lutjanus Johnii) In Coastal Waters Of Australia, Mike Cappo, Ross J. Marriott, Stephen J. Newman

Fisheries Research Articles

Demographic parameters were derived from sectioned otoliths of John’s Snapper (Lutjanus johnii) from 4 regions across 9° of latitude and 23° of longitude in northern Australia. Latitudinal variation in size and growth rates of this species greatly exceeded longitudinal variation. Populations of John’s Snapper farthest from the equator had the largest body sizes, in line with James’s rule, and the fastest growth rates, contrary to the temperature size rule for ectotherms. A maximum age of 28.6 years, nearly 3 times previous estimates, was recorded and the largest individual was 990 mm in fork length. Females grew to a larger mean …

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Not Your Everyday Story Of Cuttlefish, St. Norbert College Jul 2013

Not Your Everyday Story Of Cuttlefish, St. Norbert College

St. Norbert College Magazine 2013-2018

On the fast track to superstardom in saltwater aquaria through his work with the fragile cuttlefish, Bret Grasse ’08 has found his methods so successful that he has become the world’s go-to expert in culturing generations of cuttlefish.

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Role Of Nucleation In Cortical Microtubule Array Organization: Variations On A Theme, Erica A. Fishel, Ram Dixit Jul 2013

Role Of Nucleation In Cortical Microtubule Array Organization: Variations On A Theme, Erica A. Fishel, Ram Dixit

Biology Faculty Research

The interphase cortical microtubules (CMTs) of plant cells form strikingly ordered arrays in the absence of a dedicated microtubule-organizing center. Considerable research effort has focused on activities such as bundling and severing that occur after CMT nucleation and are thought to be important for generating and maintaining ordered arrays. In this review, we focus on how nucleation affects CMT array organization. The bulk of CMTs are initiated from γ-tubulin-containing nucleation complexes localized to the lateral walls of pre-existing CMTs. These CMTs grow either at an acute angle or parallel to the pre-existing CMT. Although the impact of microtubule-dependent nucleation is …

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New Pieces Of The Trichinella Puzzle, Edoardo Pozio, Dante S. Zarlenga Jun 2013

New Pieces Of The Trichinella Puzzle, Edoardo Pozio, Dante S. Zarlenga

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Contrary to our understanding of just a few decades ago, the genus Trichinella now consists of a complex assemblage of no less than nine different species and three additional genotypes whose taxonomic status remains in flux. New data and methodologies have allowed advancements in detection and differentia- tion at the population level which in turn have demonstrably advanced epidemiological, immunological and genetic investigations. In like manner, molecular and genetic studies have permitted us to hypothe- sise biohistorical events leading to the worldwide dissemination of this genus, and to begin crystalising the evolution of Trichinella on a macro scale. The identification …

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Plant Cytoskeleton: Della Connects Gibberellins To Microtubules, Ram Dixit Jun 2013

Plant Cytoskeleton: Della Connects Gibberellins To Microtubules, Ram Dixit

Biology Faculty Research

A new study reveals that DELLA proteins directly interact with the prefoldin complex, thus regulating tubulin subunit availability in a gibberellin-dependent manner. This finding provides a mechanistic link between the growth-promoting plant hormone gibberellin and cortical microtubule organization.

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Synergistic Inhibition Of Survival, Proliferation, And Migration Of U87 Cells With A Combination Of Ly341495 And Iressa, Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S. Mahajan May 2013

Synergistic Inhibition Of Survival, Proliferation, And Migration Of U87 Cells With A Combination Of Ly341495 And Iressa, Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S. Mahajan

Publications and Research

Glioblastomas exploit various molecular pathways to promote glutamate-dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal growth factor receptor, EGFR. We hypothesized that targeting more than one of these pathways would be more effective in inhibiting glutamate-dependent growth. Using a model of U87 cell line, we show that blocking glutamate release by Riluzole inhibits cell proliferation. Glutamate-dependent growth is effectively inhibited by a combination of Iressa, an inhibitor of EGFR activation and LY341495, a group II mGluR inhibitor. Treatment of U87 cells with a combination of Iressa and LY341495 …

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Bromus Tectorum Litter Alters Photosynthetic Characteristics Of Biological Soil Crusts From A Semiarid Shrubland, Marcelo D. Serpe, Eric Roberts, David J. Eldridge, Roger Rosentreter May 2013

Bromus Tectorum Litter Alters Photosynthetic Characteristics Of Biological Soil Crusts From A Semiarid Shrubland, Marcelo D. Serpe, Eric Roberts, David J. Eldridge, Roger Rosentreter

Biology Faculty Publications and Presentations

Invasion by the exotic annual grass Bromus tectorum has increased the cover and connectivity of fine litter in the sagebrush steppes of western North America. This litter tends to cover biological soil crusts, which could affect their metabolism and growth. To investigate this possible phenomenon, biological soil crusts dominated by either the moss Bryum argenteum or the lichen Diploschistes muscorum were covered with B.tectorum litter (litter treatment) or left uncovered (control treatment) and exposed to natural field conditions. After periods of five and ten months, we removed the litter and compared the photosynthetic performance of biological soil crusts …

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Recent Characterizations Of Mscs And Its Homologs Provide Insight Into The Basis Of Ion Selectivity In Mechanosensitive Channels, Grigory Maksaev, Elizabeth S. Haswell May 2013

Recent Characterizations Of Mscs And Its Homologs Provide Insight Into The Basis Of Ion Selectivity In Mechanosensitive Channels, Grigory Maksaev, Elizabeth S. Haswell

Biology Faculty Research

The bacterial mechanosensitive channel MscS provides an excellent model system for the study of mechanosensitivity and for investigations into the cellular response to hypoosmotic shock. Numerous studies have elucidated the structure, function and gating mechanism of Escherichia coli MscS, providing a wealth of information for the comparative analysis of MscS family members in bacteria, archaea, fungi and plants. We recently reported the electrophysiological characterization of MscS-Like (MSL)10, a MscS homolog from the model flowering plant Arabidopsis thaliana. Here we summarize our results and briefly compare MSL10 to previously described members of the MscS family. Finally, we comment on how …

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Earliest Archaeological Evidence Of Persistent Hominin Carnivory, Joseph V. Ferraro, Thomas W. Plummer, Briana L. Pobiner, James S. Oliver, Laura C. Bishop, David R. Braun, Peter W. Ditchfield, John W. Seaman, Katie M. Binetti, John W. Seaman, Fritz Hertel, Richard Potts Apr 2013

Earliest Archaeological Evidence Of Persistent Hominin Carnivory, Joseph V. Ferraro, Thomas W. Plummer, Briana L. Pobiner, James S. Oliver, Laura C. Bishop, David R. Braun, Peter W. Ditchfield, John W. Seaman, Katie M. Binetti, John W. Seaman, Fritz Hertel, Richard Potts

Publications and Research

The emergence of lithic technology by ∼2.6 million years ago (Ma) is often interpreted as a correlate of increasingly recurrent hominin acquisition and consumption of animal remains. Associated faunal evidence, however, is poorly preserved prior to ∼1.8 Ma, limiting our understanding of early archaeological (Oldowan) hominin carnivory. Here, we detail three large well-preserved zooarchaeological assemblages from Kanjera South, Kenya. The assemblages date to ∼2.0 Ma, pre-dating all previously published archaeofaunas of appreciable size. At Kanjera, there is clear evidence that Oldowan hominins acquired and processed numerous, relatively complete, small ungulate carcasses. Moreover, they had at least occasional access to the …

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Developing Stable Isotope Biomarkers Of Yup'ik Traditional And Market Foods To Detect Associations With Chronic Disease Risk, Sarah H. Nash Apr 2013

Developing Stable Isotope Biomarkers Of Yup'ik Traditional And Market Foods To Detect Associations With Chronic Disease Risk, Sarah H. Nash

Biological Sciences

This dissertation addresses the need for valid measures of dietary intake for use in studies of chronic disease risk in the Yup'ik population of Southwest Alaska. The Yup'ik people have experienced dietary changes over the past century, as consumption of traditional foods has been increasingly supplemented or replaced by market-purchased foods. Determining whether this dietary change is associated with increases in chronic disease risk is important for making nutritional recommendations for disease prevention. However, monitoring dietary change is challenging, in part due to the limitations of self-reported methods of dietary assessment. Dietary biomarkers are promising alternatives to self-reported methods, because …

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Overexpression Of Full-Length Centrobin Rescues Limb Malformation But Not Male Fertility Of The Hypodactylous (Hd) Rats, František Liška, Claudia Gosele, Elena Popova, Blanka Chylíková, Drahomíra Křenová, Vladimír Křen, Michael Bader, Laura L. Tres, Norbert Hubner, Abraham L. Kierszenbaum Apr 2013

Overexpression Of Full-Length Centrobin Rescues Limb Malformation But Not Male Fertility Of The Hypodactylous (Hd) Rats, František Liška, Claudia Gosele, Elena Popova, Blanka Chylíková, Drahomíra Křenová, Vladimír Křen, Michael Bader, Laura L. Tres, Norbert Hubner, Abraham L. Kierszenbaum

Publications and Research

Rat hypodactyly (hd) mutation is characterized by abnormal spermatogenesis and sperm decapitation, limb malformation (missing digits II and III) and growth retardation. We have previously reported centrobin (centrosome BRCA2-interacting protein) truncation at the C-terminus in the hd mutant. Here, we report data from a transgenic rescue experiment carried out to determine a role of centrobin in pathogenesis of hd. The transgenic construct, consisting of full-length-coding cDNA linked to a ubiquitous strong promoter/enhancer combination, was inserted to chromosome 16 into a LINE repeat. No known gene is present in the vicinity of the insertion site. Transgenic centrobin was expressed in all …

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