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Chelidonic Acid Abrogates Oxidative Stress And Memory Dysfunction In Experimental Aging Rats, Feri̇de Ni̇hal Si̇nan, Emel Serdaroğlu Kaşikçi, Burcu Çevreli̇

Turkish Journal of Biology

Background/aim: In an aging model established in male Wistar albino rats via the administration of D-galactose (D-gal), the aim of this study was to examine the effects of chelidonic acid on cognitive functioning and the levels of glutathione (GSH), malondialdehyde (MDA), Total antioxidant status (TAS), and brain-derived neurotrophic factor (BDNF).Materials and methods: Thirty-two Wistar albino (three month old) male rats (n = 8) were used. Group 1: Control (C), Group 2: Chelidonic acid (CA) (2 mg/kg oral gavage), Group 3: D-galactose (D-gal) (150 mg/kg, s.c.), Group 4: D-gal (150 mg/kg) + CA (2 mg/kg) (DC). Following an overnight fast, the …

Mexican Health And Aging Study Biomarker And Genetic Data Profile, Rafael Samper-Ternent, Jesús Daniel Zazueta-Borboa, Alejandra Michaels-Obregon, Dolly Reyes-Dumeyer, Sandra Barral, Giuseppe Tosto, Rebeca Wong

Faculty, Staff and Student Publications

The Mexican Health and Aging Study (MHAS) is one of the largest ongoing longitudinal studies of aging in Latin America, with six waves over 20 years. MHAS includes sociodemographic, economic, and health data from a nationally representative sample of adults 50 years and older in urban and rural Mexico. MHAS is designed to study the impact of diseases on adults' health, function, and mortality. As Mexico is experiencing rapid population aging, providing adequate information to study this phenomenon is vital for designing and implementing public policies. The availability of biomarker and genetic data and longitudinal survey data elevates opportunities for …

The Scientific Landscape Of The Aging-In-Place Literature: A Bibliometric Analysis, Saman Jamshidi, Nastaran Hashemi

Architecture Faculty Research

The world’s population is aging and, as populations age, they exhibit an increased prevalence of chronic diseases, which can reduce the independence of elderly individuals. The set of initiatives known as aging in place, a common policy response to the aging population, is preferred by both the elderly population and policymakers. Aging in place is a broad and multifaceted topic that involves multiple stakeholders and academic disciplines. A science map of the literature on aging in place can help researchers pinpoint their efforts and help policymakers make informed decisions. Thus, this study maps the scientific landscape of the aging-in-place literature. …

A Review Of The Association Between Dietary Intake And Brain Iron Levels In Older Adults: Preliminary Findings And Future Directions., Valentinos Zachariou, Christopher E. Bauer, Colleen A. Pappas, Brian T. Gold

Behavioral Science Faculty Publications

Background/Objectives: Non-heme iron is essential for critical neuronal functions such as ATP generation, synaptogenesis, neurotransmitter synthesis, and myelin formation. However, as non-heme iron accumulates with age, excessive levels can contribute to oxidative stress, potentially disrupting neuronal integrity and contributing to cognitive decline. Despite growing evidence linking high brain iron with poorer cognitive performance, there are currently no proven methods to reduce brain iron accumulation in aging or to protect cognitive function from iron’s negative effects. Recent studies suggest that nutrition may influence brain iron levels, though the evidence remains limited and mixed. Methods: In this review, we explore recent findings, …

Investigating Impacts Of The Mycothiazole Chemotype As A Chemical Probe For The Study Of Mitochondrial Function And Aging., Naibedya Dutta, Joe A Gerke, Sofia F. Odron, Joseph D. Morris, Adam Hruby, Juri Kim, Toni Castro Torres, Sarah J. Shemtov, Jacqueline G. Clarke, Michelle C. Chang, Hooriya Shaghasi, Marissa N. Ray, Maxim Averbukh, Sally Hoang, Maria Oorloff, Athena Alcala, Matthew Vega, Hemal H Mehta, Max A Thorwald, Phillip Crews, Marc Vermulst, Gilberto Garcia, Tyler A. Johnson, Ryo Higuchi-Sanabria

Natural Sciences and Mathematics | Faculty Scholarship

Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective chemical probes based on their high efficiency to inhibit ETC complex I function. Similar to rotenone (Rote), MTZ, a newly employed ETC complex I inhibitor, exhibited higher cytotoxicity against cancer cell lines compared to certain non-cancer cell lines. Interestingly, 8-OAc demonstrated greater selectivity for cancer cells …

Livable Marshfield: Age And Dementia Friendly Action Plan: Improving Livability For All Ages And Abilities, Caitlin E. Coyle, Beth Rouleau, Ceara Somerville

Center for Social and Demographic Research on Aging Publications

The Town of Marshfield’s Age and Dementia Friendly action plan signifies a milestone and reflects many years of dedication to creating environments within Marshfield that are supportive of residents of all ages and abilities. Guided by the Council on Aging (COA), the Town of Marshfield is dedicated to understanding and responding to the needs and interests of older adults in the community. Over the years, the share of residents over age 60 has steadily grown. According to 2019-2023 estimates from the American Community Survey, an estimated 28% of Marshfield residents are age 60 or older (approximately 7,200 residents). Projections suggest …

Planning For The Future Of The Easthampton Council On Aging, Caitlin E. Coyle, Sue Berger

Center for Social and Demographic Research on Aging Publications

This report describes an assessment undertaken by the Center for Social & Demographic Research on Aging (CSDRA) within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the ad hoc Senior Center Building Committee. The goals of this project were to document the features of other communities building processes, engage residents in preliminary conversation about their needs and preferences as they consider aging in Easthampton. Results of that work are described in this report and recommendations to the ad hoc building committee are provided. These recommendations are meant to provide an objective description of this preliminary community …

Chronic Β3-Ar Stimulation Activates Distinct Thermogenic Mechanisms In Brown And White Adipose Tissue And Improves Systemic Metabolism In Aged Mice, Duraipandy Natarajan, Bhuvana Plakkot, Kritika Tiwari, Shoba Ekambaram, Weidong Wang, Michael Rudolph, Mahmoud A Mohammad, Shaji K Chacko, Madhan Subramanian, Stefano Tarantini, Andriy Yabluchanskiy, Zoltan Ungvari, Anna Csiszar, Priya Balasubramanian

Faculty, Staff and Students Publications

Adipose thermogenesis has been actively investigated as a therapeutic target for improving metabolic dysfunction in obesity. However, its applicability to middle-aged and older populations, which bear the highest obesity prevalence in the United States (approximately 40%), remains uncertain due to age-related decline in thermogenic responses. In this study, we investigated the effects of chronic thermogenic stimulation using the β3-adrenergic (AR) agonist CL316,243 (CL) on systemic metabolism and adipose function in aged (18-month-old) C57BL/6JN mice. Sustained β3-AR treatment resulted in reduced fat mass, increased energy expenditure, increased fatty acid oxidation and mitochondrial activity in adipose depots, improved glucose homeostasis, and a …

Age-Related Decline In Blood-Brain Barrier Function Is More Pronounced In Males Than Females In Parietal And Temporal Regions, Xingfeng Shao, Qinyang Shou, Kimberly Felix, Brandon Ojogho, Xuejuan Jiang, Brian T Gold, Megan M Herting, Eric L Goldwaser, Peter Kochunov, Elliot Hong, Ioannis Pappas, Meredith Braskie, Hosung Kim, Steven Cen, Kay Jann, Danny J J Wang

Faculty, Staff and Student Publications

The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), and shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported in both animal and human studies, which may contribute to cognitive decline and neurodegenerative disorders. Limited data also suggest that being female may be associated with protective effects on BBB function. Here, we investigated age and sex-dependent trajectories of perfusion and BBB water exchange rate (kw) across the lifespan in 186 cognitively normal participants spanning the ages of 8-92 years old, using a non-invasive diffusion-prepared pseudo-continuous arterial …

Aging In Hanover: A Community Needs Assessment, Caitlin E. Coyle, Beth Rouleau, Ceara Somerville

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging (CSDRA), within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Town of Hanover. The report supports the Council on Aging’s objective to identify and serve the needs of residents age 55 and older. The contents of this report are meant to inform the Town of Hanover, the Hanover Council on Aging (COA), the Senior Center, and organizations that work with and on behalf of older residents of Hanover for the purposes of COA mission fulfillment alongside planning and coordination of …

Efficacy Of A Home-Based Neurocognitive Remediation Program In Adults With Hiv, Shameka C. Humphrey

Leadership Connection

Session presented on Thursday, September 25, 2014:

Despite the life-sustaining effects of Combination Antiretroviral Therapy (cART), adults with HIV continue to experience neurocognitive impairments. In fact, over half of adults with HIV experience HIV-Associated Neurocognitive Disorders (HAND). As neurocognitive impairments continue to emerge among adults with HIV, more private settings such as the home may facilitate greater use of neurocognitive remediation therapies such as speed of processing training to enhance neurocognitive and everyday functioning. The efficacy of a home-based speed of processing training was examined in middle-aged and older adults with HIV (i.e., age 40+).

Anthropology & Aging From The Editor-In-Chief, Manonita Ghosh

Research outputs 2022 to 2026

No abstract provided.

Aging In Maynard: A Community Needs Assessment, Caitlin E. Coyle, Mary Krebs

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging (CSDRA), within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Town of Maynard. The report supports the Council on Aging’s objective to identify and serve the needs of residents age 50 and older. The contents of this report are meant to inform the Town of Maynard, the Maynard Council on Aging (COA), the Senior Center, and organizations that work with and on behalf of older residents of Maynard for the purposes of COA mission fulfillment alongside planning and coordination of …

Introduction To The Special Issue On Medicare Inclusion Of Counselors: Preparing The Counseling Workforce To Serve Older Adults, Matthew C. Fullen, Jordan Westcott

Adultspan Journal

Introduction to the special issue on Medicare Inclusion of Counselors: Preparing the Counseling Workforce to Serve Older Adults.

Special Issue Editors:

Matthew Fullen, Virginia Tech

Jordan Westcott, The University of Tennessee-Knoxville

Older And Better: A Narrative Review Of Successful Aging And Adaptation To Pain In Late Life, Emanuel Narcis Husu

Faculty, Staff and Students Publications

"Invariably, the self-assessed QoL was far better than I, as a physician, would have anticipated from the diseases and disabilities that you reported." -Ben Eiseman, MD, based on a survey of his octogenarian Yale University classmates.

Background: Chronic pain control is a high priority for the elderly; it is one of the most frequently encountered medical problems in this group. Chronic pain affects 60%-75% of people aged 65 years and older. Chronic pain's prevalence is even higher in those living in assisted living or nursing homes. Based on epidemiological data, the prevalence of chronic pain is directly proportional to age …

An Interpretable Machine Learning-Based Cerebrospinal Fluid Proteomics Clock For Predicting Age Reveals Novel Insights Into Brain Aging, Justin Melendez, Yun Ju Sung, Miranda Orr, Andrew Yoo, Suzanne Schindler, Carlos Cruchaga, Randall Bateman

2020-Current year OA Pubs

Machine learning can be used to create "biologic clocks" that predict age. However, organs, tissues, and biofluids may age at different rates from the organism as a whole. We sought to understand how cerebrospinal fluid (CSF) changes with age to inform the development of brain aging-related disease mechanisms and identify potential anti-aging therapeutic targets. Several epigenetic clocks exist based on plasma and neuronal tissues; however, plasma may not reflect brain aging specifically and tissue-based clocks require samples that are difficult to obtain from living participants. To address these problems, we developed a machine learning clock that uses CSF proteomics to …

Rheumatoid Arthritis Disease Activity Is Associated With Frailty In Veterans, Courtney N. Loecker

Theses & Dissertations

Frailty, a physiologic vulnerability to everyday stressors, affects approximately 30% of the 1.3 million Americans with rheumatoid arthritis (RA) and is associated with increased risk for adverse health outcomes. Active RA manifests as inflammation, pain, and joint damage leading to functional impairments and morbidity which cumulatively influences frailty. However, the relationship between RA disease activity and frailty is incompletely understood.

This study evaluated the relationship of RA disease activity and frailty at baseline and over up to five years in Veterans. A cohort study was performed using data from the Veterans Affairs Rheumatoid Arthritis registry. RA disease activity was measured …

Intermittent Clearance Of P21-Highly-Expressing Cells Extends Lifespan And Confers Sustained Benefits To Health And Physical Function, Binsheng Wang, Lichao Wang, Nathan S Gasek, Chia-Ling Kuo, Jia Nie, Taewan Kim, Pengyi Yan, Junyu Zhu, Blake L Torrance, Yueying Zhou, Lisa C Flores, Colton Allen, Allison M Andrade, Chun Guo, Rachel L Cohn, Evan R Jellison, Jenna M Bartley, George A Kuchel, Sheng Li, Tamar Pirtskhalava, Tamar Tchkonia, Sumit Yadav, Laura Haynes, James L Kirkland, Yuji Ikeno, Ming Xu

Faculty, Staff and Student Publications

A key challenge in aging research is to extend lifespan in tandem with slowing down functional decline so that the life with good health (healthspan) can be extended. Here, we show that monthly clearance of a small number of cells, which highly express p21Cip1 (p21high), starting from 20 months improves cardiac and metabolic function, and extends both median and maximum lifespan in mice. Importantly, by assessing health and physical function of these mice monthly until death, we show that clearance of p21high cells improves physical function at all remaining stages of life, suggesting healthspan extension. Mechanistically, …

Essays On Aging, Health, And Labor Market, Lanjie Wang

Dissertations and Theses Collection (Open Access)

This dissertation consists of four chapters on aging, health, and labor economics.

In the first chapter, we investigate the short-term impacts of unemployment on older workers in Singapore, a setting without public unemployment insurance. Using monthly panel data, we analyze dynamic impacts on income, spending, health, and subjective well-being over two years post-unemployment. We find substantial initial earnings losses with incomplete recovery, with income remaining 46.5% below pre-unemployment levels after 24 months. Despite this persistent income gap, consumption responses are modest and comparable to countries with strong social safety nets, suggesting robust self-insurance mechanisms. We observe increased retirement among married …

Aging In Hopkinton: A Community Needs Assessment, Sue Berger, Caitlin E. Coyle

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging (CSDRA) within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Town of Hopkinton. The goals of this project were to investigate the needs, interests, preferences, and opinions of Hopkinton residents age 55 or older by engaging the community regarding their experiences and needs relevant to Senior Services objective to identify and serve the needs of Hopkinton’s older residents. The contents of this report are meant to inform the Town of Hopkinton, Hopkinton Senior Services, and organizations that work with and …

Aging In Newton: A Community Needs Assessment, Claire Wickersham, Katherine Burnes, Shu Xu, Caitlin E. Coyle

Center for Social and Demographic Research on Aging Publications

This report presents the results of a comprehensive examination of issues relating to aging in Newton. A needs assessment was undertaken to support planning on the part of the City of Newton and the Department of Older Adult Services. Results presented here focus on the characteristics and needs of Newton residents who are aged 60 and older. Data was collected via key informant interviews, focus groups with residents and stakeholders and a mailed survey of residents aged 60 and older. Respondents to the community survey included 2,869 Newton residents, which resulted in a response rate of more than 50%. As …

Age-Related Dysregulation Of The Retinal Transcriptome In African Turquoise Killifish, Steven Bergmans, Nicole C L Noel, Luca Masin, Ellen G Harding, Aleksandra M Krzywańska, Julie D De Schutter, Rajagopal Ayana, Chi-Kuo Hu, Lut Arckens, Philip A Ruzycki, Ryan B Macdonald, Brian S Clark, Lieve Moons

2020-Current year OA Pubs

Age-related vision loss caused by retinal neurodegenerative pathologies is becoming more prevalent in our ageing society. To understand the physiological and molecular impact of ageing on retinal homeostasis, we used the short-lived African turquoise killifish, a model known to naturally develop central nervous system (CNS) ageing hallmarks and vision loss. Bulk and single-cell RNA-sequencing (scRNAseq) of three age groups (6-, 12-, and 18-week-old) identified transcriptional ageing fingerprints in the killifish retina, unveiling pathways also identified in the aged brain, including oxidative stress, gliosis, and inflammageing. These findings were comparable to observations in the ageing mouse retina. Additionally, transcriptional changes in …

Aging As Online Faculty: Attitudes Toward Work And Retirement, Lee Stadtlander, Amy Sickel

Journal of Educational Research and Practice

Aging, an often-neglected aspect of diversity in universities, is an important issue, as the rate of people working who are 75 and older is growing faster than the rate for any other age group. The present sequential explanatory mixed-method study explored 129 older online faculty’s attitudes and opinions on work and retirement in an online survey and in 13 faculty interviews. Data were examined cross-sectionally to assess differences by decade: 50s, 60s, and 70s and above. The results indicated that while older faculty were collecting some form of retirement payment, money was not a primary motivator for working. These individuals …

A Retrospective Study Of Healthcare Needs Of Unpaid Caregivers In The United States, Ranelle M. Nissen, Jessica Mchugh Conlin, Mackenzie L. Feldhacker, Whitney Lucas Molitor, Allison J. Naber

The Open Journal of Occupational Therapy

Introduction: Demand for caregivers is on the rise. In the US, 53 million individuals provided care in 2020. Older adults constitute nearly half of all care recipients and often receive care from a family member. This study identified the health care needs of caregivers regarding health care use, access to resources, and unmet needs.

Methods: We used a retrospective, cross-sectional design to examine existing data collected between 2013 and 2018 regarding caregiver experiences. Data were analyzed using descriptive statistics and a chi-square test of independence.

Results: Caregivers were primarily female, White, between the 18 and 64 years …

The Frailty Trajectory's Additional Edge Over The Frailty Index: Retrospective Cohort Study Of Veterans With Heart Failure, Javad Razjouyan, Ariela R Orkaby, Molly J Horstman, Parag Goyal, Orna Intrator, Aanand D Naik

Faculty, Staff and Students Publications

No abstract provided.

Strategies To Recruit, Retain, And Disseminate Findings To Older Adults In Health Research: A Literature Review, Sydney Giancola, Russell Estreicher, Merna Mina

Bridges: An Undergraduate Journal of Contemporary Connections

This paper outlines various strategies to recruit, retain and disseminate information to older adults in health research. There is a limited scope on the best ways to engage with older adults, maintain their interest over time, and share their results post-data collection. This literature review aims to fill this gap and discuss various methods to increase the engagement of the older adult population in health research.

A Comprehensive Examination Of Age-Related Lower Limb Muscle Function Asymmetries Across A Variety Of Muscle Action Types, Kylee L. Heap-Eldridge, Brennan J. Thompson, Cody Fisher, Talin J. Louder, Jon Carey

Kinesiology and Health Science Faculty Publications

Previous research has found that lower limb muscle asymmetries increase with age and are linked to fall and injury risks. However, past studies lack a wide variety of muscle function modes and measures as well as comparison to a comparable younger age group. The purpose of this study was to examine age-related lower limb muscle function asymmetries across a variety of muscle action types and velocities in young and old adults. Lower limb balance, strength, power, and velocity were evaluated with concentric, isometric, isotonic, and eccentric muscle actions during a single-leg stance test and on single- and multi-joint dynamometers in …

The Hidden Struggle: Challenges Older Women Face In Nevada, Annie Vong

Student Research

In 2020, almost one in five Nevadans was over the age of 65.[1] However, within this age group, women outnumber men due to longer life expectancies[2] and migration patterns. Women over 65 years of age make up an estimated 18.1% of the female population in Nevada.[3] Of the male population in Nevada, 15.1% are over 65 years of age.[4] Older women are less likely to be married, are less likely to have completed a bachelor’s degree, are more likely to drop out of the labor force, and are more likely to be living in poverty in …

Understanding Older People’S Voice Interactions With Smart Voice Assistants: A New Modified Rule-Based Natural Language Processing Model With Human Input, Zhengxu Yan, Victoria Dube, Judith Heselton, Kate Johnson, Changmin Yan, Valerie Jones, Julie Blaskewicz Boron, Marcia Shade

College of Journalism and Mass Communications: Faculty Publications

The COVID-19 pandemic has expedited the integration of Smart Voice Assistants (SVA) among older people. The qualitative data derived from user commands on SVA is pivotal for elucidating the engagement patterns of older individuals with such systems. However, the sheer volume of user-generated voice interaction data presents a formidable challenge for manual coding. Compounding this issue, age-related cognitive decline and alterations in speech patterns further complicate the interpretation of older users’ SVA voice interactions. Conventional dictionary-based textual analysis tools, which count word frequencies, are inadequate in capturing the evolving and communicative essence of these interactions that unfold over a series …

Investigation Of The Impact Of Neighborhood Environments On Alzheimer’S Disease And Alzheimer’S Disease-Related Dementias (Ad/Adrd), Darashagam Nahal

2024 Spring Honors Capstone Projects - Archive

There is an increased interest in understanding the impact of neighborhood environments on cognitive functioning, cognitive impairment, and Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). Surprisingly, there has yet to be a comprehensive review that consolidates the findings from studies conducted in this specific field. The purpose of this study is to comprehensively investigate the influence of eight neighborhood environments on AD/ADRD. The seven key neighborhood environments that are investigated in this study include: i) socioeconomic status, ii) food environments, iii) physical activity resources, iv) social cohesion, v) crime, vi) non-crime safety, and vii) healthcare services. This research conducts a …