Digital Commons Network^™

Restricting Bioenergetic Efficiency Enhances Longevity And Mitochondrial Redox Capacity In Drosophila Melanogaster, Analisa L. Taylor, Olga Dubuisson, Pritika Pandey, Elizabeth R.M. Zunica, Bolormaa Vandanmagsar, Wagner S. Dantas, Alyssa Johnson, Christopher L. Axelrod, John P. Kirwan

Division of Basic Science Faculty Publications

Mitochondria are essential for survival and as such, impairments in organelle homeostasis significantly accelerate age-related morbidity and mortality. Here, we determined the contribution of bioenergetic efficiency to life span and health span in Drosophila melanogaster utilizing the mitochondrial uncoupler BAM15. Life span was determined in flies fed a normal diet (ND) or high fat diet (HFD) supplemented with vehicle or BAM15. Locomotor function was determined by negative geotaxis assay in middle-aged flies fed vehicle or BAM15 under ND or HFD conditions. Redox capacity (high-resolution respirometry/fluorometry), citrate synthase (enzyme activity), mtDNA content (qPCR), gene expression (qPCR), and protein expression (western blot) …

Examining The Risks And Resilience Of Older Adults Living With Hiv/Aids: Qualitative Community-Based Participatory Research Studies In Southern Nevada, Brandon Ranuschio

UNLV Theses, Dissertations, Professional Papers, and Capstones

Since the height of the HIV pandemic in the 1980s, medical interventions have significantly increased the life expectancy of people living with HIV/AIDS (PLWH) and made HIV/AIDS a livable, chronic health condition. Because of this, PLWH have been living longer lives and thriving with the help of HIV sector healthcare and service providers. However, with their longer life expectancy, older PLWH have been experiencing other health challenges. One such challenge is the risk of developing HIV-Associated Neurocognitive Disorder (HAND), which is a condition that affects up to 50% of PLWH at some point in their lifetime, with middle-aged and older …

The Greater Implications Of Self-Perceptions Of Aging Among Younger Adults: Results From The Socially Nutritious Volunteer Training Program, Ashlyn Cobble

Electronic Theses and Dissertations

The rapidly growing rate of the older adult population has created a need to better understand younger adults’ self-perceptions of aging and current trends of ageism. The purpose of this secondary data analysis research project was to determine changes, if any, in participants’ self-perception of aging after the Socially Nutritious facilitator or nutrition ambassador volunteer training, which aims to develop knowledge and skills related to aging trends, older adult nutrition, preventing ageism, and communication and educational considerations when working with older adults. Findings indicate that participants with more frequent interactions with older adults had a more positive perception of their …

Changes In Young Adults’ Perspective On Ageism After Participating In A Virtual Nutrition Education Program With Older Adults, Julianne Hensley

Electronic Theses and Dissertations

The growing older adult population has led to increased ageist tendencies among younger generations. Previous research suggests that ageism is associated with cognitive and physical decline among older adults. This mixed-methods research project examined changes in ageist perceptions among graduate student facilitators and undergraduate nutrition ambassadors after participating in a training that included information about healthy aging, addressing ageism, and communicating with older adults. Results from a secondary data analysis of pre-test/post-test data and thematic analysis of semi-structured interviews with facilitators of Socially Nutritious, a virtual nutrition education program for older adults, indicate that ageist perceptions decreased after the …

A Comprehensive Examination Of Age-Related Lower Limb Muscle Function Asymmetries Across A Variety Of Muscle Contraction Types, Kylee Heap

All Graduate Reports and Creative Projects, Fall 2023 to Present

Previous research has found that lower limb muscle asymmetries increase with age and are linked to fall and injury risks. However, past studies lacked a wide variety of muscle function modes and measures as well as comparison to a comparable young aged group. The purpose of this study was to examine age-related lower limb muscle function asymmetries across a variety of muscle contraction types and velocities in young and old adults. Lower limb muscle balance, strength, power, and velocity were evaluated with concentric, isometric, isotonic, and eccentric muscle actions during a single-leg stance test and on single- and multi-joint dynamometers …

Factors Influencing Driving Confidence In Older Adults, Jill Linder, Beth Ann Walker, Elizabeth Moore, Anne Hegberg

The Open Journal of Occupational Therapy

Background: It has been determined that both confidence and cognition impact driving performance and self-regulation. While it is known that cognitive decline impacts driving safety and that decreases in driving confidence can lead to self-driving regulation, further research is needed to determine whether cognition, demographics, and driving routines are associated with driving confidence.

Method: A non-experimental, cross-sectional design study using a convenience sample of 100 older adults was conducted to determine if individual factors are related to daytime and nighttime driving confidence.

Results: Multiple regression indicated that four variables predicted daytime driving confidence, including cognition, driving at …

Peer-Mediated Family Support Project: Evaluation Of Changes In Family Quality Of Life, Preethy S. Samuel, Elizabeth Janks, Nia S. Anderson, Michael Bray, Christina Topolewski, Sharon Milberger

Developmental Disabilities Network Journal

The Family Quality of Life (FQOL) approach represents a paradigm shift from fixing to supporting people with intellectual/developmental disabilities (I/DD) by changing the focus from the individual to the family and highlighting strengths rather than deficiencies. Aging family caregivers of individuals with I/DD often encounter obstacles, including accessibility, acceptability, and affordability of services. Little is known about best practices to support aging families of adults with I/DD. Understanding how a state-wide peer-mediated family support project implemented in this study helped improve the FQOL of aging caregivers is important in broadening participation of other caregivers in these types of programs. To …

Does A Reduction In Receiving Assistance With Daily Activities Among Older Adults In Mexico Indicate An Increase In Unmet Needs Or A Decrease In Needs For Care?, Brian Downer, Rafael Samper-Ternent, Philip Cantu, Matthew Miller, Rebeca Wong

Faculty, Staff and Student Publications

OBJECTIVES: The percentage of older adults in Mexico with difficulty completing activities of daily living (ADL) who receive assistance from family appears to be decreasing. We compared 2 birth cohorts of older adults in Mexico to investigate whether this trend reflects an increase in unmet caregiving needs or a decrease in the need for care.

METHODS: We selected Mexican Health and Aging Study participants aged 60-76 in 2001 (n = 4,805) and 2018 (n = 6,494). ADL tasks were dressing, walking, bathing, getting in and out of bed, and toileting. Participants who reported difficulty with an ADL were asked if …

Tavr In Older Adults, Abdulla A Damluji, Gwen Bernacki, Jonathan Afilalo, Radmila Lyubarova, Ariela R Orkaby, Min Ji Kwak, Scott Hummel, James N Kirkpatrick, Mathew S Maurer, Nanette Wenger, Michael W Rich, Dae Hyun Kim, Roberta Y Wang, Daniel E Forman, Ashok Krishnaswami

Faculty, Staff and Student Publications

Calcific aortic stenosis can be considered a model for geriatric cardiovascular conditions due to a confluence of factors. The remarkable technological development of transcatheter aortic valve replacement was studied initially on older adult populations with prohibitive or high-risk for surgical valve replacement. Through these trials, the cardiovascular community has recognized that stratification of these chronologically older adults can be improved incrementally by invoking the concept of frailty and other geriatric risks. Given the complexity of the aging process, stratification by chronological age should only be the initial step but is no longer sufficient to optimally quantify cardiovascular and noncardiovascular risk. …

Aging In The City Of Melrose: A Community Needs Assessment, Caitlin E. Coyle, Katherine Burnes, Mark Krebs, Ceara Somerville

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging (CSDRA) within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the City of Melrose. The goals of this project were to investigate the interests, preferences, and opinions of Melrose’s residents aged 55 or older by engaging the community regarding their experiences and needs relevant to the Council on Aging’s (COA’s) objective to identify and serve the needs of all Melrose citizens 55 and older. The contents of this report are meant to inform the City of Melrose, the Melrose COA, Milano …

Aging In North Andover: A Community Needs Assessment, Claire Wickersham, Caitlin E. Coyle, Ceara Somerville, Holly Stockdale

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging (CSDRA) within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Town of North Andover. The goal of this project was to identify, describe, and prioritize the needs and preferences of North Andover residents age 60 and older as they relate to aging well in the community. In 2023, North Andover opened a new Senior Community Center. The contents of this report are intended to be used for planning for the new Senior Community Center space and to inform strategic planning …

Improving Safety And Preventing Falls Using An Evidence-Based, Front-Line Staff Huddling Practice: Protocol For A Pragmatic Trial To Increase Quality Of Care In State Veterans Homes, Princess Nash, Valerie Clark, Eleanor Mcconnell, Whitney Mills, Robert Morgan, Camilla Pimentel, Katherine Ritchey, Cari Levy, A Lynn Snow, Christine Hartmann

Faculty, Staff and Student Publications

Introduction: Falls in nursing homes are a major cause for decreases in residents' quality of life and overall health. This study aims to reduce resident falls by implementing the LOCK Falls Programme, an evidence-based quality improvement intervention. The LOCK Falls Programme involves the entire front-line care team in (1) focusing on evidence of positive change, (2) collecting data through systematic observation and (3) facilitating communication and coordination of care through the practice of front-line staff huddles.

Methods and analysis: The study protocol describes a mixed-methods, 4-year hybrid (type 2) effectiveness-implementation study in State Veterans Homes in the USA. The study …

Calorie Restriction Reduces Biomarkers Of Cellular Senescence In Humans, Zaira Aversa, Thomas A. White, Amanda A. Heeren, Cassondra A. Hulshizer, Dominik Saul, Xu Zhang, Anthony J.A. Molina, Leanne M. Redman, Corby K. Martin, Susan B. Racette, Kim M. Huffman, Manjushri Bhapkar, Sundeep Khosla, Sai Krupa Das, Roger A. Fielding, Elizabeth J. Atkinson, Nathan K. Lebrasseur

Clinical Research Faculty Publications

Calorie restriction (CR) with adequate nutrient intake is a potential geroprotective intervention. To advance this concept in humans, we tested the hypothesis that moderate CR in healthy young-to-middle-aged individuals would reduce circulating biomarkers of cellular senescence, a fundamental mechanism of aging and aging-related conditions. Using plasma specimens from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 study, we found that CR significantly reduced the concentrations of several senescence biomarkers at 12 and 24 months compared to an ad libitum diet. Using machine learning, changes in biomarker concentrations emerged as important predictors of the change …

Calorie Restriction Reduces Biomarkers Of Cellular Senescence In Humans, Zaira Aversa, Susan B Racette, Et Al.

2020-Current year OA Pubs

Calorie restriction (CR) with adequate nutrient intake is a potential geroprotective intervention. To advance this concept in humans, we tested the hypothesis that moderate CR in healthy young-to-middle-aged individuals would reduce circulating biomarkers of cellular senescence, a fundamental mechanism of aging and aging-related conditions. Using plasma specimens from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 study, we found that CR significantly reduced the concentrations of several senescence biomarkers at 12 and 24 months compared to an ad libitum diet. Using machine learning, changes in biomarker concentrations emerged as important predictors of the change …

Aging Fly Cell Atlas Identifies Exhaustive Aging Features At Cellular Resolution, Kenneth A Wilson, Sudipta Bar, Eric B Dammer, Enrique M Carrera, Brian A Hodge, Tyler A U Hilsabeck, Joanna Bons, George W Brownridge, Jennifer N Beck, Jacob Rose, Melia Granath-Panelo, Christopher S Nelson, Grace Qi, Akos A Gerencser, Jianfeng Lan, Alexandra Afenjar, Geetanjali Chawla, Rachel B Brem, Philippe M Campeau, Hugo J Bellen, Birgit Schilling, Nicholas T Seyfried, Lisa M Ellerby, Pankaj Kapahi

Faculty, Staff and Students Publications

Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids. Loss of mtd/OXR1 destabilized the retromer, causing improper protein trafficking and endolysosomal defects. Overexpression of retromer genes or pharmacological restabilization with R55 rescued lifespan and neurodegeneration in mtd-deficient flies and endolysosomal defects in fibroblasts from patients with lethal loss-of-function …

Ageannomo: A Knowledgebase Of Multi-Omics Annotation For Animal Aging, Kexin Huang, Xi Liu, Zhaocan Zhang, Tiangang Wang, Haixia Xu, Qingxuan Li, Yuhao Jia, Liyu Huang, Pora Kim, Xiaobo Zhou

Faculty, Staff and Student Publications

Aging entails gradual functional decline influenced by interconnected factors. Multiple hallmarks proposed as common and conserved underlying denominators of aging on the molecular, cellular and systemic levels across multiple species. Thus, understanding the function of aging hallmarks and their relationships across species can facilitate the translation of anti-aging drug development from model organisms to humans. Here, we built AgeAnnoMO (https://relab.xidian.edu.cn/AgeAnnoMO/#/), a knowledgebase of multi-omics annotation for animal aging. AgeAnnoMO encompasses an extensive collection of 136 datasets from eight modalities, encompassing 8596 samples from 50 representative species, making it a comprehensive resource for aging and longevity research. AgeAnnoMO characterizes …

Age-Related Delay In Reduced Accessibility Of Refreshed Items, Julie A. Higgins, Matthew R. Johnson, Marcia K. Johnson

Department of Psychology: Faculty Publications

Previously we demonstrated that in young adults briefly thinking of (i.e., refreshing) a just-seen word impairs immediate (100ms delay) perceptual processing of the word, relative to words seen but not refreshed. We suggested that such reflective-induced inhibition biases attention towards new information. Here, we investigated whether reduced accessibility of refreshed targets dissipates with a longer delay, and whether older adults would show a smaller and/or delayed effect, versus young adults. Young and older adult participants saw two words, followed by a cue to refresh one. After either a 100ms or 500ms delay, participants read a word that was the …

Strategies For Integrating Aging And Older Adulthood Into Counselor Training, Matthew C. Fullen, Jordan Westcott, Kailey Bradley, Natese R. Dockery, Jungeun Lee, Rumbidzai Mushunje, Afroze N. Shaikh

Adultspan Journal

Following recent changes to Medicare mental health law, counselors will have expanded opportunities to work with older adults. Historically, there has been a dearth of counselor training dedicated to counseling older adults, necessitating greater attention to understanding and applying best practices for preparing counselors to serve older adult clients. Looking to professions that have a longer history of serving older adults, specifically gerontology, social work, and geropsychology, we describe approaches to training counselors to work with older adults that may prove helpful for the counseling profession.

A Qualitative Analysis Of Community-Dwelling Older Adults’ Perspectives Of Elderspeak, Katelynn Shimanski

All Graduate Theses, Dissertations, and Other Capstone Projects

Compared to other forms of discrimination, ageism, and specific forms of ageism such as elderspeak are understudied. Despite the fact that the majority of older adults are community-dwelling, much of the existing literature on elderspeak focuses on caregiver perceptions on elderspeak occurring in assisted living facilities and nursing homes. The present study analyzed community dwelling older adult’s perceptions of elderspeak using their personal examples of experiences of elderspeak. Results indicated that the majority of participants had negative perceptions of elderspeak that would likely not be influenced by changes in contextual factors such as setting, relationship to the speaker, and gender …

A Community-Academic Partnered Approach To Designing A Virtual Village To Address The Needs Of Older Adults Living With Hiv, Annie L. Nguyen, Andrea N. Polonijo, Jerome T. Galea, Moka Yoo-Jeong, Jeff Taylor, Erik L. Ruiz, Karah Greene, Jasmine L. Lopez, Christopher Christensonf, Brandon Brown

Social Work Faculty Publications

Many older adults living with HIV face unique challenges, including comorbidities, loneliness, and isolation. This community-academic partnered study elicited viewpoints from older adults living with HIV about the characteristics of a digital environment (“Virtual Village”) to combat against loneliness and isolation. We utilized Choice-Based Conjoint Analyses to determine preferred attributes of a Virtual Village. We also conducted focus groups and interviews with older adults living with HIV and used an iterative, data-driven approach to systematically identify emergent themes. Participants (N = 82) were aged 50–82 years and racially/ethnically diverse. The majority were men (78%), gay (66%), and lived with …

Environmentalism Among Older Adults: Investigating Predictors Of Pro-Environmental Behavior In Later Life, Ajit Singh Mann

CGU Theses & Dissertations

Human actions are largely responsible for degradation of the natural environment, and environmental threats due to climate change are increasingly prevalent. Despite the immediate need to conserve the natural environment, the role of older adults in pro-environmental initiatives has largely been ignored. I conducted two studies to understand pathways for promoting pro-environmental behavior among older adults, with the goal of shedding light on older adults’ engagement in environmental action. In the first study, I investigated the indirect effect of age on pro-environmental behavior, through personal values and environmental concern, among a general sample (N=292). I considered the role of flow …

The Missoula Senior Center, Fifty Years Of History 1970-2020, A Narrative, Mark L. Spring

Undergraduate Theses, Professional Papers, and Capstone Artifacts

This is the story of the Missoula Senior Center over fifty years. It began, struggled, and remains a center for gathering and sharing experiences. It started before its christening in 1969.

The history presented in these pages has been compiled from interviews, newspaper articles, Blazing Trails, The Board of Directors records, member contributions, and The First Thirty Years of History Missoula Senior Citizen’s Center by past member June Gordon Phythian.

Sex-Driven Alterations In Aging Alpha Motoneurons: Exploring Size, Type, Density, And Kv2.1 Channel Expression, Kalin R. Gerber

Browse all Theses and Dissertations

This research explores how motor neurons (MNs) and Kv2.1 clustering change with age, emphasizing sex differences and MN subtypes. We found that MN density decreases with age in both sexes, while soma size increases in male mice. FF MNs were the most affected, and old weak mice had smaller MNs than their stronger counterparts, underscoring FF MN vulnerability. Baseline studies revealed that FF and FI MNs have larger Kv2.1 clusters compared to FR and S MNs. Female mice had smaller, denser Kv2.1 clusters than male mice, suggesting less clustering in females. With age, Kv2.1 clusters grew larger but became less …

The Effect Of Intermittent Fasting, Caloric Restriction And Exercise On Aging And Longevity: Systematic Review, Romi Hardin

Honors Undergraduate Theses

The purpose of this study was to gain a better understanding of the effects of caloric restriction, intermittent fasting, and exercise on human longevity and aging, and explore their practical applications and inclusions into a healthy lifestyle. By reviewing the existing research and studies, this literature review focuses on identifying and explaining the biological mechanism behind these practices and exploring whether combining practices can be advantageous in extending not only lifespan but health span. The results generally indicate that following either caloric restriction or intermittent fasting and participating in regular exercise have immense results on promoting healthy aging in an …

The Relationship Of Neighborhood Disadvantage, Biological Aging, And Psychosocial Risk And Resilience Factors In Heart Failure Incidence Among Black Persons: A Moderated Mediation Analysis, Ganga S Bey, James R Pike, Anthony S Zannas, Qian Xiao, Bing Yu, Amil M Shah, Priya Palta

Faculty, Staff and Student Publications

Objectives: Deprived living environments contribute to greater heart failure (HF) risk among non-Hispanic Black persons, who disproportionately occupy disadvantaged neighborhoods. The mechanisms for these effects are not fully explicated, partially attributable to an insufficient understanding of the individual factors that contribute additional risk or resilience to the impact of neighborhood disadvantage on health. The objective of this study was, therefore, to clarify the complex pathways over which such exposures act to facilitate more targeted, effective interventions. Given the evidence for a mediating role of biological age and a moderating role of individual psychosocial characteristics in the neighborhood disadvantage-HF link, we …

Childlessness And Sibling Positioning In Upward Intergenerational Support: Insights From Singapore, Dahye Kim, Christine Ho, Bussarawan Teerawichitchainan

Research Collection School Of Economics

Objective: This brief report aims to explore the role of child-lessness and its interaction with sibling positioning (i.e., birth order and gender) in upward intergenerational support within the context of Asian familial and patrilineal values. Background: Despite the increasing rates of childlessness in Asia, little is known about how childless individuals deviate from or adhere to the patrilineal gendered practices of supporting their older parents. Singapore, a rapidly aging nation that emphasises Confucian familism values and patrilineal practices in guiding its welfare policies, provides an ideal setting for this research investigation. Method: We analysed a sample of 475 Singaporeans aged …

The Contribution Of Amyloid Deposition In The Aortic Valve To Calcification And Aortic Stenosis, Romeesa Khan, Claudia M Di Gesù, Juneyoung Lee, Louise D Mccullough

Faculty, Staff and Student Publications

Trillions of microbes live symbiotically in the host, specifically in mucosal tissues such as the gut. Recent advances in metagenomics and metabolomics have revealed that the gut microbiota plays a critical role in the regulation of host immunity and metabolism, communicating through bidirectional interactions in the microbiota-gut-brain axis (MGBA). The gut microbiota regulates both gut and systemic immunity and contributes to the neurodevelopment and behaviors of the host. With aging, the composition of the microbiota changes, and emerging studies have linked these shifts in microbial populations to age-related neurological diseases (NDs). Preclinical studies have demonstrated that gut microbiota-targeted therapies can …

Diet-Stimulated Marrow Adiposity Fails To Worsen Early, Age-Related Bone Loss, Cody Mcgrath, Sarah E Little-Letsinger, Gabriel M Pagnotti, Buer Sen, Zhihui Xie, Gunes Uzer, Guniz B Uzer, Xiaopeng Zong, Martin A Styner, Janet Rubin, Maya Styner

Faculty, Staff and Student Publications

Introduction: Longitudinal effect of diet-induced obesity on bone is uncertain. Prior work showed both no effect and a decrement in bone density or quality when obesity begins prior to skeletal maturity. We aimed to quantify long-term effects of obesity on bone and bone marrow adipose tissue (BMAT) in adulthood.

Methods: Skeletally mature, female C57BL/6 mice (n = 70) aged 12 weeks were randomly allocated to low-fat diet (LFD; 10% kcal fat; n = 30) or high-fat diet (HFD; 60% kcal fat; n = 30), with analyses at 12, 15, 18, and 24 weeks (n = 10/group). Tibial microarchitecture was analyzed …

Aging And Urinary Control: Alterations In The Brain-Bladder Axis., Cara C Hardy, Ron Korstanje

Faculty Research 2023

Age-associated alterations in bladder control affect millions of older adults, with a heavy burden added to families both economically and in quality of life. Therapeutic options are limited with poor efficacy in older adults, lending to a growing need to address the gaps in our current understanding of urinary tract aging. This review summarizes the current knowledge of age-associated alterations in the structure and function of the brain-bladder axis and identifies important gaps in the field that have yet to be addressed. Urinary aging is associated with decreased tissue responsiveness, decreased control over the voiding reflex, signaling dysfunction along the …

Impact Of The Built Environment On The End-Of-Life Journey, Kelechi Akwazie

Masters in Architecture Program: Theses

Several research studies and personal anecdotes show that home-based hospice care patients report better quality of life than their inpatient care counterparts – suggesting that the location of care/built environment is a critical component of hospice care. As a result, other research studies have attempted to provide evidence-based design recommendations for inpatient hospice facilities; however, several of these recommendations either conflict with each other or are vaguely prescribed – which may dull any attempts to implement them.

This literature review takes a unique approach to the provision of evidence-based design recommendations for inpatient hospice facilities by holistically assessing hospice care, …