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Order-Restricted Covariate Effects And Hazard Regression Models., Arnab Bhattacharjee Dr.

Doctoral Theses

The proportional hazards (PH) model, but more speciÖcally its special case the Cox regression model (Cox, 1972), plays an important role in the theory and practice of lifetime and duration data analysis. This is because the PH model (and the Cox regression model) provides a convenient way to evaluate the ináuence of one or several covariates on the probability of conclusion of lifetime or duration spells. However, the PH speciÖcation substantially restricts interdependence between the explanatory variables and the lifetime in determining the hazard. In particular, the Cox regression model model restricts the coe¢ cients of the regressors in the …

Semantic Knowledge For Famous Names In Mild Cognitive Impairment, Michael Seidenberg, Leslie Guidotti, Kristy A. Nielson, John L. Woodard, Sally Durgerian, Qi Zhang, Amelia Gander, Piero Antuono, Stephen M. Rao

Psychology Faculty Research and Publications

Person identification represents a unique category of semantic knowledge that is commonly impaired in Alzheimer's disease (AD), but has received relatively little investigation in patients with mild cognitive impairment (MCI). The current study examined the retrieval of semantic knowledge for famous names from three time epochs (recent, remote, and enduring) in two participant groups: 23 amnestic MCI (aMCI) patients and 23 healthy elderly controls. The aMCI group was less accurate and produced less semantic knowledge than controls for famous names. Names from the enduring period were recognized faster than both recent and remote names in both groups, and remote names …

A Grounded Theory Study Of Grief In The Lives Of Lesbians Age 60 And Older: Implications For Practice And Societal Change, Ginger Charlyne Meyette

Electronic Theses and Dissertations

The purpose of this study is to understand the lived experiences of self-identified lesbians age 60 and older concerning grief related to various life experiences and to develop a grounded theory related to the findings. The purpose goes beyond describing the phenomenon of grief focusing on grief related exclusively to death loss. The purpose includes eliciting comments about grief related to overt or covert discrimination due to ageism, sexism, and/or homophobia as well as the connection between the personal and the political in terms of what needs to change to bring about social justice.

The issue of grief in the …

Pilot Community-Based Intervention To Address The Needs Of Elderly Caregivers In The Eastern Cape Province, South Africa, Priscilla Reddy, Shegs James, H. Mutumba Bilay-Boon, Eka Esu-Williams, Hena Khan

HIV and AIDS

The HIV epidemic in South Africa has placed a substantial burden on elderly caregivers, mainly women, who are often tasked with caring for their grandchildren who are orphaned and rendered vulnerable by the death or illness of their parents. The Medical Research Council (MRC), Age-in-Action, and the Horizons Program conducted formative research, as described in this research summary, to assess the needs of elderly caregivers in the Eastern Cape Province of South Africa in 2005. The investigations revealed that elderly caregivers faced a number of challenges including difficulty communicating with youth, fears and a sense of hopelessness around matters regarding …

The Lived Experiences Of Older African Americans Residing In Urban Nursing Homes, Marilynn Gail Byrd Knall

Wayne State University Theses

As huge numbers of baby boomers reach old age, an increased need for nursing home care in the future is inevitable. Older people face more complex health issues that often lead to debilitation or disability and thus the need for long-term care. The numbers of consumers needing long-term care services will more than triple during the next 30 years.

African Americans compose less than 10% of nursing home residents and even at age 84 and older, when the likelihood of nursing home placement is higher, proportionately fewer African Americans live in nursing homes. The underrepresentation of ethnic minorities groups in …

Beyond The Observable: Examining Self-Reported Well-Being In People With Dementia, Wingyun Mak

All Theses and Dissertations (ETDs)

The well-being of people with dementia is not well understood. Researchers often measure their well-being through observational methods or via proxies, but self-report is rarely used. Recently there is evidence that people with mild to moderate dementia are able to give reliable reports of their well-being, but empirical work in this area is limited. Most dementia-specific measures focus on mood or life satisfaction, and there are few that gauge more existential aspects of well-being: e.g., purpose in life). This study tested the use of a non-dementia-specific well-being measure in people with mild to moderate dementia. The relationship between goal pursuit, …

Aging In Place In Suburbia: A Qualitative Study Of Older Women, Marian L.G. Knapp

Antioch University Dissertations & Theses

This research explored "aging in place" among women age 65 and older living in Newton, Massachusetts. Study goals were to understand: the "places" that comprise the environment of "aging in place"; the factors that enable "aging in place"; "aging in place" in a suburb; and to refine definitions of "aging in place" Interviews with women used open-ended questions about women‘s early years in Newton and the changes they experienced in personal status, and places over time. Themes emerged using modified grounded theory with inductive and deductive approaches, and which acknowledged "sensitizing concepts". Six places comprised the "aging in place" environment: …

Social Practices, Moral Frameworks And Religious Values In The Lives Of Older People, Carmel Gallagher

Books/Book chapters

No abstract provided.

Estrogen And Hippocampal Plasticity In Rodent Models, Michael R. Foy, Michel Baudry, Roberta Diaz Brinton, Richard F. Thompson

Psychological Science Faculty Works

Accumulating evidence indicates that ovarian hormones regulate a wide variety of non-reproductive functions in the central nervous system by interacting with several molecular and cellular processes. A growing animal literature using both adult and aged rodent models indicates that 17β-estradiol, the most potent of the biologically relevant estrogens, facilitates some forms of learning and memory, in particular those that involve hippocampal-dependent tasks. A recently developed triple-transgenic mouse (3xTg-AD) has been widely used as an animal model of Alzheimer's disease, as this mouse exhibits an age-related and progressive neuropathological phenotype that includes both plaque and tangle pathology mainly restricted to hippocampus, …

Examining Neurophysiological Evidence Of Age-Related Interactions Of Sensory And Cognitive Processes During Speech Processing, Cady Kristen Block

Psychology Theses & Dissertations

The present study sought to examine the contribution of sensory and cognitive factors on speech processing as evidenced by ERP measures and to find support for the Sensory Cognitive Interaction Theory (SCIT) and the Effortfulness Hypothesis in that older adults. who experience sensory deficits with normal aging. must put forth increased effort during early sensory stages of speech processing that may compromise subsequent semantic performance and recall of information. In the present investigation. younger and older adults performed a sentence verification task at low and high presentation levels (PL). Accuracy and response time to sentence verifications were assessed along with …

The Class Of ’65: Boomers At Sixty Recall Turning Points That Shaped Their Lives A Narrative Approach, Mary C. Poole

USF Tampa Graduate Theses and Dissertations

This dissertation explores the lives of baby boomers turning sixty as they use narrative to review their past by focusing on turning points. They reflect upon their present, and anticipate their future. The story begins at the St. Pius X High School Class of 1965's fortieth reunion, and proceeds to a class sixtieth birthday celebration and focus group. In addition, five members of the class record their life stories retrospectively. This research explores issues of identity, both personal and generational; the social construction of aging; grief, loss and death; and resilience, meaning, and spirituality. Methods used are autoethnography, narrative, participant …

Subjective And Objective Napping And Sleep In Older Adults: Are Evening Naps “Bad” For Nighttime Sleep?, Natalie D. Dautovich, Christina S. Mccrae, Meredeth A. Rowe

Nursing Faculty Publications

Objectives: To compare objective and subjective measurements of napping, and to examine the relationship between evening napping and nocturnal sleep in older adults.

Design: For twelve days, participants wore actigraphs and completed sleep diaries.

Setting: Community

Participants: 100 individuals who napped, 60–89 years (including good and poor sleepers with typical age-related medical comorbidities).

Measurements: Twelve days of sleep diary and actigraphy provided subjective and objective napping and sleep data.

Results: Evening naps (within 2 hours of bedtime) were characteristic of the sample with peak nap time occurring between 20:30–21:00 (average nap time occurred between 14:30–15:00). Two categories of nappers were …

Aging And Partial Body Weight Support Affects Gait Variability, Anastasia Kyvelidou, Max J. Kurz, Julie L. Ehlers, Nikolaos Stergiou

Journal Articles

Background: Aging leads to increases in gait variability which may explain the large incidence of falls in the elderly. Body weight support training may be utilized to improve gait in the elderly and minimize falls. However, before initiating rehabilitation protocols, baseline studies are needed to identify the effect of body weight support on elderly gait variability. Our purpose was to determine the kinematic variability of the lower extremities in young and elderly healthy females at changing levels of body weight support during walking.

Methods: Ten young and ten elderly females walked on a treadmill for two minutes with a body …

Counting Or Discounting Television Information: An Examination Of Viewer Perceptions About Old-Age From A Cognitive Processing Perspective Of Cultivation Effects, Lynda Pasteur

USF Tampa Graduate Theses and Dissertations

Cultivation theory (Gerbner & Gross, 1976) suggests that the cumulative effect of heavy exposure to television's underrepresentation and negative portrayal of people 65+ as sexless, insignificant, and comical can cause people to assume such television-like perceptions of the age group in the real world. This study's purpose was to explore not only television's cultivation effect on viewers' perceptions of the number and nature of people 65+, but also the psychological processes that are expected to mediate this effect. As an extension of Shrum, Wyer, and O'Guinn's (1998) study on the role of source discounting in cultivation, this quasi-experiment employed three …

Spirituality And Aging In Social Work: State Of The Art And Future Possibilities, Holly Nelson-Becker, Edward R. Canda

Social Work: School of Social Work Faculty Publications and Other Works

This article identifies the unique contributions social work has made to the study of spirituality and religion in relation to aging, based on respect for their diverse expressions. Definitions of religion and spirituality that particularly relate to late life are provided. The study of spirituality and aging is situated in four historical phases ranging from sectarian origins (1890s to 1920), to professionalization and secularization (1920s-1970s), to renewed interest (1980s to mid 1990s), to the current phase characterized by transcending boundaries. Interdisciplinary research by social workers is prevalent. Topics of study include a wide range of religious and nonreligious spiritual perspectives, …

Attitudes Towards One’S Aging Among Single, Professional, Highly Educated, Baby Boom Women: “I Don’T Know Who I Am, But I Am Not A Crazy Old Maid!”, Tatyana Shepel

Antioch University Dissertations & Theses

Age is a value-laden cultural construct as it conveys social attitudes toward aging. This qualitative research, using a grounded theory approach and critical feminist gerontology as a theoretical framework, makes visible the experience of growing older and the renegotiation of self-identity among the ten single, professional, highly educated women ages 47-59 who resided in the Pacific Northwest and lets their voices be heard. In this study ten in-depth interviews and one focus group provided narrative data that captured women’s experiences of aging and uncovered common themes. The explored phenomenon of aging is experienced in the various socio-cultural contexts and conditions …

Clinical Educators' Reactions To Ageing, Anne Mandy, Kevin Lucas, Lisa Hodgson

Internet Journal of Allied Health Sciences and Practice

Ageism and negative attitudes towards ageing have been identified within the literature as a cause for concern. Reactions to ageing are known to be strongly positively correlated with attitudes towards older people in general. Moreover, the link between ageist practice and quality of care is also established, but implications for education and training have not been explored. The aim of this study was to investigate the reactions to ageing of clinical and fieldwork educators of undergraduate students. Clinical and field work educators are largely responsible for all the clinical education received by these students and thus have the potential to …

A Hierarchy Of Medicine: Health Strategies Of Elder Khmer Refugees In The United States, Denise C. Lewis

The Qualitative Report

This study addresses ways Khmer refugee elders utilize traditional herbal medicine with Western biomedicine in the treatment and prevention of illnesses. Methods include semi-structured and informal interviews with elders and family members, semi-structured interviews with local health care providers and Khmer physicians, and participant observation of everyday life and actions specific to health beliefs and behaviors. Data reveal a reliance on traditional medical ideology for understanding and treating illnesses. Utilizing a traditional ideology, Khmer elders rely heavily on traditional treatments and use Western biomedicine as supplements or adjuncts to traditional preventive and curative practices. This research has important implications for …

Rethinking Retirement Policy In Massachusetts, Ellen A. Bruce

New England Journal of Public Policy

Women are significantly poorer than men in old age. One major cause of women’s disproportional poverty is retirement income policy that bases pensions and savings incentives on earned income. This paper describes the structure of our retirement policies and argues that some policies should be implemented that are not associated with earned income as a way to both support women’s caregiving roles and insure their economic well-being in old age.

Aging Influences Multiple Indices Of Oxidative Stress In The Heart Of The Fischer 344/Nnia X Brown Norway/Binia Rat, Shinichi Asano

Theses, Dissertations and Capstones

Here we report the influence of aging on multiple markers of oxidativenitrosative stress in the heart of adult (6-month), aged (30-month) and very aged (36- month) Fischer 344/NNiaHSd X Brown Norway/BiNia (F344/NXBN) rats. Compared to 6 month old rat hearts, indices of oxidative (superoxide anion (–O2 ·), 4-hyrdoxy-2- nonenal (4-HNE)) and nitrosative (protein nitrotyrosylation) stress were 34.1 ± 28.1%, 186 ± 28.1% and 94 ± 5.8% higher, respectively, in 36-month hearts and these findings were highly correlated with increases in left ventricular wall thickness (r>0.669; r>0.710 and p<0.01, respectively). Regression analysis showed that increases in cardiac oxidative-nitrosative stress with aging were significantly correlated with changes in the expression and/or regulation of proteins involved in transcriptional (NF-κB) activities, signaling (mitogen activated protein kinases along with Src), apoptotic ( Bcl-2, Traf-2), and cellular stress (HSPs). These results suggest that the aging F344/NXBN heart may be highly suited for unraveling the molecular events that lead to age-associated alterations in cardiac oxidative stress.

Age-Related Dgc Structure And Function In The F344/N X Bn Rat Heart, Sunil K. Kakarla

Theses, Dissertations and Capstones

Recent data has suggested that disruption of the dystrophin-glycoprotein complex (DGC) may be involved in mediating the progression of cardiac hypertrophy and failure. Here we examined the regulation of DGC proteins in the hearts of adult (6 months), aged (30 months), and very aged (36 months) F344/N X BN rats . Compared to adult animals, the content of α- and β-dystroglycan were 6.93 ± 5.16% and 58.36 ± 3.64% higher, respectively (P < 0.05) in very aged animals. Immunoblotting and immunhistochemical analysis suggested that aging appeared to diminish alpha-sarcoglycan, beta-sarcoglycan and delta-sarcoglycan content by 13.89 ± 3.1%,15.8 ± 2.8% and 18.63 ± 3.04%, respectively (P < 0.05). These alterations in the DGC occurred coincident with age- associated alterations in cytoplasmic anti-rat IgG immunoreactivity, TUNEL positive nuclei, alpha-fodrin cleavage, indices of caspase-3 activation and diminished AKT phosphoryation (Ser 308). Taken together, these data suggest that aging alters cardiac DGC structure and function.

Gendered Support Strategies Of The Elderly In The Gwembe Valley, Zambia, Lisa Cliggett

Anthropology Faculty Publications

No abstract provided.

Conducting Cross-Cultural Research In Teams And The Search For The “Culture-Proof” Variable, Patricia Draper

Department of Anthropology: Faculty Publications

Objective: Cross-cultural research must always deal with the problem that meaning systems and behaviors cannot be readily compared from one culture to the next because the sociocultural context can vary so widely.
Design: The organizers of Project AGE: Age, Generation, and Experience, a multicultural study of aging, recognized this problem and devised instruments for studying age that allowed for cultural variation as well as comparability at higher levels of abstraction. The principal investigators of Project AGE and the individual researchers made every effort to gain an emic understanding (understanding based on categories recognized by the local respondents) of people’s attitudes …

Powerless Or Perilous? : Ageing Women As An Emerging Social Force In Hong Kong, Kit Ling Luk

Lingnan Theses

Ageing women have so often been represented in government policy rhetoric, gerontology literatures and journalistic discourse as the genderless, powerless and passive objects of welfare and services;, by and large, as a social problem that needs to be monitored and managed. Taking a cultural research approach, this thesis explores ageing women’s actual practices in Hong Kong social movements and aims to rerepresent ageing women as active social agents capable of generating multiple “tactical identities” enabling them to participate in and interact with an environment that poses concrete challenges to their participation.

In filling the gap between research on social movements …

Changes In Formal-Informal Caregiving In Elderly Stroke Survivors, Holly Anne Beard

Health Services Research Dissertations

The purpose of this study is to determine the extent to which the Andersen and Aday Model of Health Services Use to predict cross-sectional and longitudinal differences in the caregiving source among stroke survivors (n=477) over a six-year period. This study involves a secondary analysis of a longitudinal panel study focusing upon three waves of interview data from the HAS/AHEAD study spanning 1998 through 2002. Multinomial logistic regression was utilized to examine caregiving source cross-sectionally at each wave. Clustered multinomial logistic regression was used to examine relationships between predictor variables in the model and caregiving source across waves while holding …

Deterioro Cognoscitivo Y Factores Asociados En Adultos Mayores En México [Cognitive Impairment And Associated Factors In Older Adults In Mexico], Silvia Mejia-Arango, Alejandro Miguel-Jaimes, Antonio Villa, Liliana Ruiz-Arregui, Luis Miguel Gutiérrez-Robledo

School of Medicine Publications

OBJECTIVE: To determine the prevalence of cognitive impairment in the elderly and its relation with sociodemographic and health factors in the Mexican population.

MATERIAL AND METHODS: From the first wave data of the National Aging and Health Study, collected in 2001 in Mexico, subjects 65 years or older and who had completed a cognitive assessment were selected. Subjects were classified according to two groups: with and without cognitive impairment, based on the cutoff point corresponding to the 10th percentile of the total cognitive assessment score, adjusted for age and educational level. All subjects with cognitive impairment that also had difficulty …

A Dyadic Examination Of Daily Health Symptoms And Emotional Well-Being In Late-Life Couples, Jeremy B. Yorgason, David Almeida, Shevaun D. Neupert, Avron Spiro Iii, Lesa Hoffman

Department of Psychology: Faculty Publications

This study investigated the link between daily health symptoms and spousal emotional well-being in a sample of 96 older dyads. Higher negative mood and lower positive mood were associated with spousal symptoms in couples wherein husbands or wives reported higher average levels of symptoms. For wives, partner effects were moderated by husbands’ marital satisfaction and illness severity. Specifically, higher husband marital satisfaction and illness severity were associated with higher negative mood and lower positive mood for wives on days where husbands reported higher symptom levels. In their work with later-life families, practitioners and educators should address long-term and daily health-related …

Age-Associated Changes In Hearts Of Male Fischer 344/Brown Norway F1 Rats, Ernest M. Walker Jr., Michael S. Nillas, Elsa I. Mangiarua, Sylvestre Cansino, Ryan G. Morrison, Romaine R. Perdue, William E. Triest, Gary L. Wright, Mark Studeny, Paulette Wehner, Kevin M. Rice, Eric R. Blough

MIIR Faculty Research

Aging is associated with left ventricular hypertrophy, dilatation, and fibrosis of the heart. The Fischer 344/Brown Norway F1 (F344/BNF1) rat is recommended for age-related studies by the National Institutes on Aging because this hybrid rat lives longer and has a lower rate of pathological conditions than inbred rats. However, little is known about age-associated changes in cardiac and aortic function and structure in this model. This study evaluated age-related cardiac changes in male F344/BNF1 rats using ECHO, gross, and microscopic examinations. Rats aged 6-, 30-, and 36-mo were anesthetized and two-dimensional ECHO measurements, two-dimensional guided M-mode, Doppler M-mode, and other …

Interspecies Comparison Of Pentosidine Accumulation And Its Correlation With Age In Birds, Jesse A. Fallon, Robert L. Cochrane, Brian Dorr, Hillar Klandorf

United States Department of Agriculture Wildlife Services: Staff Publications

Recent studies suggest that a linear correlation exists between the age of individual birds and accumulation of the advanced glycation endproduct pentosidine (Ps). We compared Ps accumulation in skin tissue of Ruffed Grouse (Bonasa umbellus) and Double-crested Cormorants (Phalacrocorax auritus). Skin samples were taken from the breasts of 52 Ruffed Grouse of known ages ranging from a few days to 10 years. Skin was cleaned of feathers and adipose tissue, acid hydrolyzed, and measured for collagen content via hydroxyproline spectrophotometric assay. Pentosidine concentrations were determined using reverse-phase high-performance liquid chromatography. Fluorescent detection (excitation: 310 nm, emission: …

Urban Versus Rural Mortality Among Older Adults In China, Zachary Zimmer, Toshiko Kaneda, Laura Spess

Poverty, Gender, and Youth

For some time, Chinese government policies have treated rural and urban areas very differently, and a by-product of China’s rapid development seems to be an even greater differentiation between urban and rural social and economic life. Over the next several decades, in part because of rapid fertility declines and in part as a result of mortality declines at older ages, China and other developing countries will experience enormous increases in the proportion of older adults and the proportion of the “oldest-old.” It is reasonable to expect that these age structure changes will alter the provision of health care, making an …