Digital Commons Network^™

Oxidative Stress Accumulates In Adipose Tissue During Aging And Inhibits Adipogenesis, Hannes M. Findeisen, Kevin J. Pearson, Florence Gizard, Yue Zhao, Hua Qing, Karrie L Jones, Dianne Cohn, Elizabeth B. Heywood, Rafael De Cabo, Dennis Bruemmer

Saha Cardiovascular Research Center Faculty Publications

Aging constitutes a major independent risk factor for the development of type 2 diabetes and is accompanied by insulin resistance and adipose tissue dysfunction. One of the most important factors implicitly linked to aging and age-related chronic diseases is the accumulation of oxidative stress. However, the effect of increased oxidative stress on adipose tissue biology remains elusive. In this study, we demonstrate that aging in mice results in a loss of fat mass and the accumulation of oxidative stress in adipose tissue. In vitro, increased oxidative stress through glutathione depletion inhibits preadipocyte differentiation. This inhibition of adipogenesis is at …

Aging Is Associated With Positive Responding To Neutral Information But Reduced Recovery From Negative Information, Carien M. Van Reekum, Stacey M. Schaefer, Regina C. Lapate, Catherine J. Norris, Lawrence L. Greischar, Richard J. Davidson

Dartmouth Scholarship

Studies on aging and emotion suggest an increase in reported positive affect, a processing bias of positive over negative information, as well as increasingly adaptive regulation in response to negative events with advancing age. These findings imply that older individuals evaluate information differently, resulting in lowered reactivity to, and/or faster recovery from, negative information, while maintaining more positive responding to positive information. We examined this hypothesis in an ongoing study on Midlife in the US (MIDUS II) where emotional reactivity and recovery were assessed in a large number of respondents (N = 159) from a wide age range (36–84 …

Neural Activity, Neural Connectivity, And The Processing Of Emotionally-Valenced Information In Older Adults: Links With Life Satisfaction, Robert J. Waldinger, Elizabeth A. Kensinger, Marc S. Schulz

Psychology Faculty Research and Scholarship

This study examines whether differences in late-life well-being are linked to how older adults encode emotionally-valenced information. Using fMRI with 39 older adults varying in life satisfaction, we examined how viewing positive and negative images affected activation and connectivity of an emotion-processing network. Participants engaged most regions within this network more robustly for positive than for negative images, but within the PFC this effect was moderated by life satisfaction, with individuals higher in satisfaction showing lower levels of activity during the processing of positive images. Participants high in satisfaction showed stronger correlations among network regions – particularly between the amygdala …

Healthy Aging And Self-Objectification The Impact Of Empowerment And Feminist Attitudes On Body Image, Eating Behavior, And Aging Satisfaction, Karen P. Grippo

Electronic Theses and Dissertations

The purpose of this study was to contribute to women’s healthy aging across the adult lifespan by empirically examining potential protective factors (e.g., empowerment and feminist attitudes) in maintaining positive body image, healthy eating behavior, and aging satisfaction. Objectification Theory (Fredrickson & Roberts, 1997) provided a theoretical framework for understanding the connections between sexual-objectification experiences, media influences, and self-objectification, and the resulting negative psychological consequences for women in Western society. This study was the first to examine empowerment in relation to Objectification Theory. Additionally, a developmental perspective was gained by using a diverse sample of young, middle-aged, and older women …

The Implications Of Socioeconomic Status And A Usual Source Of Care For The Health And Health Care Experiences Of Elders With Chronic Illnesses, Michelle L. Stransky

Doctoral Dissertations

Recently developed models of health care provision have promoted the relationship between providers and patient for improving care continuity and coordination. This may be especially important for the growing population of elders, who often have fragmented care because of multiple chronic illnesses. Previous research shows that elders who have a usual source of care (USC) have better health and health care experiences than other elders. However, research has rarely considered whether the benefits of USCs may be affected by the elder's socioeconomic status (SES), their levels of chronic illness, or various provider characteristics.

This dissertation utilizes the 2007 Medicare Current …

Obesity-Mediated Inflammatory Microenvironment Stimulates Osteoclastogenesis And Bone Loss In Mice, Ganesh V. Halade, Amina El Jamali, Paul J. Williams, Roberto J. Fajardo, Gabriel Fernandes

Internal Medicine Faculty Publications

Clinical evidence indicates that fat is inversely proportional to bone mass in elderly obese women. However, it remains unclear whether obesity accelerates bone loss. In this report we present evidence that increased visceral fat leads to inflammation and subsequent bone loss in 12-month-old C57BL/6J mice that were fed 10% corn oil (CO)-based diet and a control lab chow (LC) for 6. months. As expected from our previous work, CO-fed mice demonstrated increased visceral fat and enhanced total body fat mass compared to LC. The adipocyte-specific PPARγ and bone marrow (BM) adiposity were increased in CO-fed mice. In correlation with those …

Ovarian Hormones, Aging And Stress On Hippocampal Synaptic Plasticity, Michael R. Foy

Psychological Science Faculty Works

The ovarian steroid hormones estradiol and progesterone regulate a wide variety of non-reproductive functions in the central nervous system by interacting with molecular and cellular processes. A growing literature from studies using rodent models suggests that 17β-estradiol, the most potent of the biologically relevant estrogens, enhances synaptic transmission and the magnitude of long-term potentiation recorded from in vitro hippocampal slices. In contrast, progesterone has been shown to decrease synaptic transmission and reduce hippocampal long-term potentiation in this model system. Hippocampal long-term depression, another form of synaptic plasticity, occurs more prominently in slices from aged rats. A decrease in long-term potentiation …

Survival Analysis With Censored Outcomes, Henry T. Robertson

All ETDs from UAB

This dissertation is arranged in the three-paper format. The unifying theme of the dissertation is estimating longevity in terms of years of life lost (YLL). The papers are presented in order of increasing methodological focus. The first paper, No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight, was published in the International Journal of Obesity in 2010. Although sibutramine reduced food intake and body weight, it had no association with longevity. The conclusions were based on data from a 2-year toxicology trial required by the FDA. Although this paper was largely applied …

Implications Of Lifecourse Epidemiology For Research On Determinants Of Adult Disease, Sze Yan Liu, R N. Jones, M Maria Glymour

Department of Public Health Scholarship and Creative Works

Many diseases commonly associated with aging are now thought to have social and physiologic antecedents in early life. Understanding how the timing of exposure to early life risk factors influences later-life health may illuminate mechanisms driving adult health inequalities and identify possible points for effective interventions. Recognizing chronic diseases as developing across the lifecourse also has implications for the conduct of research on adult risk factors for disease. We review alternative conceptual models that describe how the timing of risk factor exposure relates to the development of disease. We propose some expansions of lifecourse models to improve their relevance for …

An Examination Of Caregiving Dyads: Community Dwelling Chronically Ill Older Adults And Their Caregivers, Jessica E. Haxton

Electronic Theses and Dissertations

Increases in life expectancy among older adults raise important concerns about the availability of resources for an aging population living with chronic and debilitating illnesses. Living longer is complicated by the fact that many elders prefer to reside in their homes until medical or other conditions require an alternative living arrangement. The strong desire to remain at home expressed by older persons in the United States has in turn created an increased demand on informal caregiving. Consequently, adult children often bear the burden of providing care to their aging parents. In view of this demand it is critical that research …

Alterations In The Cellular Composition Of The Mouse Bladder Following Ovariectomy, Partial Bladder Outlet Obstruction, And Aging, Diane Holly Smith

Honors Scholar Theses

Detrusor underactivity (DU) increases susceptibility to urinary retention and accordingly further complicates the management of urinary incontinence. Bladder muscle stretch, a lack of estrogen, and aging are 3 notable DU risk factors. The aim of this research is to better characterize the changes in cellular composition of the bladder that result from these 3 risk factors to gain a better understanding of DU pathogenesis and pathobiology. This research focuses on the effects of a lack of estrogen while also providing an outline for determining the effects of bladder muscle stretch and aging on the cellular composition of the bladder.

Aging-Dependent Effects Of Repetitive Loading Exercise And Antioxidant Supplementation On Oxidative Stress In Skeletal Muscle, Michael J. Ryan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Aging is associated with a reduced ability to buffer oxidants along with an increase in oxidant production, resulting in chronic oxidative stress. Oxidative stress is a putative factor responsible for reducing function ability of skeletal muscle and increasing oxidative damage. The objective of this set of investigations was to evaluate the efficacy of reducing oxidative stress on improving muscle function the adaptive response of skeletal muscle to repetitive loading exercise in aging rodents. To achieve this objective, three methods of reducing oxidative stress were utilized; the antioxidant vitamins E&C were used to buffer oxidants, the nutraceutical resveratrol was used to …

Observing The Elderly Through The Eyes Of A Developmental Theorist, Chinyelu Onuora

XULAneXUS

No abstract provided.

Attractor Divergence As A Metric For Assessing Walking Balance, Max J. Kurz, Katerina Markopoulou, Nikolaos Stergiou

Journal Articles

: Individuals with Parkinson's disease and the aged have a high prevalence of falls. Since an increase in the number of falls is associated with physical and psychological harm, it is prudent that biomechanical metrics be established that will accurately assess an individual's walking balance. In this investigation, we initially used a simple bipedal walking computer model to theoretically establish the relationship between attractor divergence and walking balance. The Lyapunov exponent was used to quantify the amount of divergence present in the walking attractor. Simulations from our model indicated that attractors that have a greater amount of divergence are more …

What’S Love Got To Do With It?: Social Connections, Perceived Health Stressors, And Daily Mood In Married Octogenarians, Robert J. Waldinger, Marc S. Schulz

Psychology Faculty Research and Scholarship

This study examined day-to-day links among time spent with others, health stressors, and mood in 47 elderly couples over an 8-day period. Hierarchical linear modeling revealed daily links between time spent with others and mood for men. For both men and women, being in a satisfying relationship was associated with stronger positive daily links between spending time with one’s partner and mood. Women reported lower mood on days when they experienced greater pain and physical limitation, and all participants reported lower mood on days when they experienced other health stressors. Marital satisfaction but not time spent with others buffered day-to-day …

Facing The Music Or Burying Our Heads In The Sand?: Adaptive Emotion Regulation In Mid- And Late-Life, Robert J. Waldinger, Marc S. Schulz

Psychology Faculty Research and Scholarship

Psychological defense theories postulate that keeping threatening information out of awareness brings short-term reduction of anxiety at the cost of longer-term dysfunction. By contrast, Socioemotional Selectivity Theory suggests that preference for positively-valenced information is a manifestation of adaptive emotion regulation in later life. Using six decades of longitudinal data on 61 men, we examined links between emotion regulation indices informed by these distinct conceptualizations: defense patterns in earlier adulthood and selective memory for positively-valenced images in late life. Men who used more avoidant defenses in midlife recognized fewer emotionally-valenced and neutral images in a memory test 35-40 years later. Late-life …

Total Number Of Synapses In The Adult Human Neocortex, Thai Nguyen

Undergraduate Journal of Mathematical Modeling: One + Two

The brain is composed of glial cells and neurons where synapses form connections between neurons and other cells. Since synapses are very small, so either a light or electron microscope is required to see them. Unlike other mammals, synapses in the human brain deteriorate rapidly upon death making them difficult to study. This project constructs a simple model for the number of synapses in the human neocortex by age and sex based on the amount of neurons. This hypothetical model can also be used to study the impact of Alzheimer's disease and other forms of dementia that are marked by …

Our Grandparents, Our Parents, Our Future Selves: Optimizing Function In Old Age., Thomas Michael Gill

Center for Policy Research

Most of my research at Yale University School of Medicine over the past several years has focused on identifying older adults at risk of functional decline and disability, identifying events that may precipitate the transition from functional independence to disability, and developing strategies to postpone or reduce frailty and disability. As a result of the Precipitating Events Project (PEP) and other research conducted by the Yale Center on Aging/Pepper Center, we now realize that age is only a proxy for other factors that lead to disability, and that some of these factors can be modified to reduce the risk of …

An Occupational Therapy Program To Help Community Dwelling Seniors Age In Place, Amy Lundberg, Kayla Novacek

Occupational Therapy Capstones

Purpose: It is estimated that by 2030, one in five people in the United States will be 65 or older (US Census Bureau, 2008). An aging in place initiative has come to the forefront of health care to help seniors cope with the age related challenges, allowing seniors to experience productive aging in their own homes. The purpose of this scholarly project was to develop an occupation based aging in place wellness program for community dwelling elderly.

Methods: A literature review was conducted to identify the current challenges associated with aging. In addition, the literature review identified strengths and limitations …

Lactate Dyscrasia: A Novel Explanation For Amyotrophic Lateral Sclerosis, Sivan Vadakkadath Meethal, Craig Atwood

Research outputs pre 2011

Amyotrophic lateral sclerosis (ALS; Lou Gehrig’s disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS that involves an adenosine triphosphate (ATP)-dependent muscle neuronal lactate shuttle (MNLS) at the neuromuscular junction (NMJ) to regulate the flow of lactate from muscle to neurons and vice versa. Failure of the MNLS due to respiratory chain dysfunction is proposed to result in lactate toxicity and degeneration of nerve endings at the NMJ leading to nerve terminus dysjunction from the muscle cell. At a critical threshold where denervation outpaces reinnervation, a vicious cycle …

Effectiveness Of Strategies For Solving Everyday Problems During Early And Later Adulthood: A Reexamination Of The Everyday Problem Solving Inventory, Joseph P. Mcfall

Graduate Theses, Dissertations, and Problem Reports (ETD)

Within the everyday problem-solving literature, a small number of studies have examined effectiveness as a problem-solving outcome measure. Effectiveness is a method of determining the quality of strategies used to solve ill-defined problems. Knowing the effectiveness of a problem-solving strategy can help determine whether an age differences in the use of that strategy also indicates better everyday outcomes for one age group. Of the few studies that have examined age differences in effective problem solving, none have systematically assessed the dimensions that make some strategies effective and others ineffective for various problem situations. In addition, a variety of methodological considerations …

Aging And The Vulnerability Of Speech To Dual Task Demands, Susan Kemper, Ralynn Schmalzried, Lesa Hoffman, Ruth Herman

Department of Psychology: Faculty Publications

Tracking a digital pursuit rotor task was used to measure dual task costs of language production by young and older adults. Tracking performance by both groups was affected by dual task demands: time on target declined and tracking error increased as dual task demands increased from the baseline condition to a moderately demanding dual task condition to a more demanding dual task condition. When dual task demands were moderate, older adults’ speech rate declined but their fluency, grammatical complexity, and content were unaffected. When the dual task was more demanding, older adults’ speech, like young adults’ speech, became highly fragmented, …

Nonlinear Analysis Of Ambulatory Activity Patterns In Community-Dwelling Older Adults, James T. Cavanaugh, Naomi Kochi, Nikolaos Stergiou

Journal Articles

Background The natural ambulatory activity patterns of older adults are not well understood. User-worn monitors illuminate patterns of ambulatory activity and generate data suitable for analysis using measures derived from nonlinear dynamics.

MethodsAmbulatory activity data were collected continuously from 157 community-dwelling older adults for 2 weeks. Participants were separated post hoc into groups based on the mean number of steps per day: highly active (steps ≥ 10,000), moderately active (5,000 ≤ steps < 10,000 steps), and inactive (steps

Results All groups displayed patterns of fluctuating step count values containing complex temporal structure. DFA, ER, and ApEn parameter values increased monotonically and significantly with increasing activity …

Spirituality And Ageing : A Qualitative Study Of Religiosity Of Chinese Older Persons In Hong Kong, Yuk Ha Wong

Lingnan Theses

The life expectancy of Chinese people in Hong Kong is increasing and is amongst the longest in the world. However, many people, especially older persons may experience chronic ill-health and, less detectable, many may also be experiencing alienation, loneliness, meaninglessness and fear of death. Spirituality and spiritual care, which focus on the healing of the soul and quest for meaning, are important to many people as they age and face the prospect of death, and therefore they may have existential anxieties. A holistic healthcare approach, which views humans as bio-psycho-social-spiritual beings, stresses the importance of spirituality to people’s health and …

Domestic Violence Or Elder Abuse? Why It Matters For Older Women, Teresa Kilbane, Marcia K. Spira

Social Work: School of Social Work Faculty Publications and Other Works

Law enforcement and legal services are 2 systems that respond to reports of abuse against women through programs such as adult protective services (APS) and domestic violence (DV). APS and DV systems operate independently and define the cause of the abuse differently. The designation of a woman as having suffered domestic violence or having been abused often depends on which system she enters. This designation can lead to different options for women to obtain services. Aging may further complicate access and usability of these systems to respond to the needs of abused elderly. Using vignettes, this article explores the definitions …

Spirituality And Aging (Review), Holly Nelson-Becker

Social Work: School of Social Work Faculty Publications and Other Works

Review of Robert C. Atchley 'Spirituality and Aging.'

A Cost Analysis Of A Physical Activity Intervention For Older Adults, Erik J. Groessl, Robert M. Kaplan, Steven N. Blair, W. Jack Rejeski, Jeffrey A. Katula, Abby C. King, Roger A. Fielding, Nancy W. Glynn, Marco Pahor

Faculty Publications

We examined the costs of a physical activity (PA) and an educational comparison intervention. 424 older adults at risk for mobility disability were randomly assigned to either condition. The PA program consisted of center-based exercise sessions 3x weekly for 8 weeks, 2x weekly for weeks 9 to 24 and weekly behavioral counseling for 10 weeks. Optional sessions were offered during maintenance weeks (25-52). The comparison intervention consisted of weekly education meetings for 24 weeks, and then monthly for 6 months. Cost analyses were conducted from the "payer's" perspective, with a 1-year time horizon. Intervention costs were estimated by tracking personnel …

Crisis Model For Older Adults: Special Considerations For An Aging Population, Christian M. Jungers, Leslie Slagel

Adultspan Journal

No abstract provided.

Research Brief No. 1 - Social Inclusion Of The Oldest-Old: Toward Supportive Housing Policies, Judy Lynn Richards, Susan Sverdrup-Phillips, Jiangqin Du, Heather Maddocks, Heather Spiegel, Jennifer Brooks

Population Change and Lifecourse Strategic Knowledge Cluster Research/Policy Brief

Although most seniors aged 85+ live relatively independently in the community, research on this age group tends to focus on the negative aspects of aging. This study looks instead at seniors aged 85 and older who are living well and semi-independently in their communities with the help of an informal care provider. The study aims to identify the mechanisms that allow them to live with dignity and autonomy in their own homes and remain socially included in their communities. We conducted in-depth, semi-structured interviews with 16 individuals aged 85 to 94 years and their primary informal support-persons in Southwestern Ontario, …

Successful Aging Through The Eyes Of Alaska Native Elders: What It Means To Be An Elder In Bristol Bay, Alaska, Jordan Paul Lewis

Psychology

Alaska Natives view aging from a holistic perspective, an approach not typically found in the existing literature on successful aging. There is little research on Alaska Native (AN) Elders and how they subjectively define a successful older age. The lack of a culturally specific definition often results in the use of a generic definition that portrays AN Elders as aging less successfully than their non-Native counterparts. This research explores the concept of successful aging from an AN perspective and what it means to age well in AN communities. An Explanatory Model (EM) approach was used and adapted to focus on …