Digital Commons Network^™

Response Inhibition Deficits In Women With The Fmr1 Premutation Are Associated With Age And Fall Risk, Carly Moser, Lyndsay Schmitt, Joseph Schmidt, Amanda Fairchild, Jessica Klusek

Faculty Publications

One in 113-178 females worldwide carry a premutation allele on the FMR1 gene. The FMR1 premutation is linked to neurocognitive and neuromotor impairments, although the phenotype is not fully understood, particularly with respect to age effects. This study sought to define oculomotor response inhibition skills in women with the FMR1 premutation and their association with age and fall risk. We employed an antisaccade eye-tracking paradigm to index oculomotor inhibition skills in 35 women with the FMR1 premutation and 28 control women. The FMR1 premutation group exhibited longer antisaccade latency and reduced accuracy relative to controls, indicating deficient response inhibition skills. …

Quantitative Proteomic And Metabolomic Profiling Reveals Altered Mitochondrial Metabolism And Folate Biosynthesis Pathways In The Aging Drosophila Eye, Hana Hall, Bruce R. Cooper, Guihong Qi, Aruna B. Wijeratne, Amber L. Mosley, Vikki M. Weake

Department of Biochemistry Faculty Publications

Aging is associated with increased risk of ocular disease, suggesting that age-associated molecular changes in the eye increase its vulnerability to damage. Although there are common pathways involved in aging at an organismal level, different tissues and cell types exhibit specific changes in gene expression with advanced age. Drosophila melanogaster is an established model system for studying aging and neurodegenerative disease that also provides a valuable model for studying age-associated ocular disease. Flies, like humans, exhibit decreased visual function and increased risk of retinal degeneration with age. Here, we profiled the aging proteome and metabolome of the Drosophila eye and …

Area Agencies On Aging Provide Crucial Support For Older New Yorkers During Covid-19, Claire Pendergrast

Population Health Research Brief Series

This research brief discusses how Area Agencies on Aging are providing crucial support for older NewYorkers during COVID-19.

"I Wish I Had Known"—Understanding Barriers To Accessing Aging-Related Resources, Sue Schneider, Allyson Brothers

Journal of Extension

There is a growing imperative to ensure that aging-related resources and information are accessible to older adults and caregivers as the population ages. Extension can play an important role in associated education and outreach. We report on the results of a community assessment conducted in Larimer County, Colorado, that addressed barriers to information access. The results of our assessment demonstrated that many people were not finding the right entry point to access the services they needed. These findings inform strategies being applied in Senior Access Points of Larimer County, a program that encompasses a coordinated, county-wide outreach campaign.

The Role Of Ms-818 In Altering Age-Related Characteristics Of An In Vitro Model Of Senescence In Neural Stem Cells, Sandeep Sreerama

Honors Undergraduate Theses

Aging of the brain is the leading risk factor for neurodegenerative diseases and brain cancers and has deleterious effects on brain functions. It follows that attempts to reverse the aging process may be therapeutically valuable. Neural stem cells (NSC) have been shown to play a critical role in maintaining brain functions, and their number is severely decreased with age. The development of senescence-like characteristics and declining functions in NSCs have been proposed to be responsible for brain aging and tumorigenesis. MS-818 is a pyrrolopyrimidine that has been shown to increase the NSC population and reverse the decline of behavioral function …

Epigenetic Clock And Methylation Studies In Elephants, Natalia A. Prado, Janine L. Brown, Joseph A. Zoller, Amin Haghani, Mingjia Yao, Lora R. Bagryanova, Michael G. Campana, Jesús E. Maldonado, Dennis L. Schmitt, For Complete List Of Authors, See Publisher's Website.

College of Agriculture

Age-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age ("epigenetic clocks") in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants. These clocks were developed using novel DNA methylation profiles of 140 elephant blood samples of known age, at loci that are highly conserved between mammalian species, using a custom Infinium array (HorvathMammalMethylChip40). We present epigenetic clocks for Asian elephants (Elephas maximus), African elephants (Loxodonta africana), and both elephant species combined. Two additional human-elephant clocks were constructed by combining human and elephant samples. Epigenome-wide association studies identified elephant …

Sibling Conflict And Caregiving For Aging Parents, Jennifer Elise Lawer

Department of Conflict Resolution Studies Theses and Dissertations

This dissertation presents the results of a grounded theory study of the key factors of sibling conflict when caregiving for an aging parent. Following interviews with 30 participants, I conducted initial coding, focused coding and theoretical coding, which led to the development of a theory that explains the relationship of conflict factors such as: beliefs & values, feelings & emotions, roles & expectations, and behaviors & responses. The dissertation includes a discussion of how birth order theories, power theories and psychodynamic theories apply to sibling conflict. In addition, I discuss how the findings apply to conflict resolution skills and offer …

Psychological Sense Of Community Among Older Adults In Puerto Rico Two Years After Hurricane María, Thomas D. Buckley

Theses and Dissertations

Hurricane María devastated Puerto Rico in 2017 and resulted in adverse long-term outcomes. Psychological sense of community (PSOC) may serve as a protective factor against the effects of Hurricane María for older adults in Puerto Rico. Using a three-paper format, this dissertation draws on a resilience framework and theories of PSOC and the Ecological Theory of Aging to examine the role of PSOC among older adults in Puerto Rico two years after Hurricane María.

Paper one is a scoping review of the concept of PSOC in research with community dwelling older adults. I begin by presenting findings on study characteristics …

Trained And Derived Relational Responding, Jonathan D. Sober

Wayne State University Dissertations

Introduction: Persons with preclinical Alzheimer’s disease (AD) show impairments in semantic and associative memory years before the onset of clinical symptoms. However, many tasks used to assess these deficits make use of previously learned stimuli, often within well-established semantic networks that may be more resistant to disease-related changes. No research has been conducted examining trained and derived relational responding (TDRR) in older adults or in the presence of AD risk factors. The purpose of this study was to determine whether a novel TDRR task would be sensitive to age-related and disease-risk cognitive changes. Method: Thirty younger adults and 15 older …

Resident Centered Behavioral Health: A Program Evaluation, Anna Olinger

All Graduate Theses, Dissertations, and Other Capstone Projects

Behavioral health concerns, such as depression and behavioral symptoms, impact older adults at significant rates. These concerns impact an individual’s quality of life, health status, and mortality. When behavioral health concerns cannot be effectively managed in the community by the individual or their caregivers, a skilled-nursing facility is often the next step. Unfortunately, those caring for older adults in these settings have not always had access to the training they need to care for individuals with depression or behavioral symptoms. The Resident Centered Behavioral Health program set out to change this. The program implemented an interactive, behavioral health training program …

Muscle Mass And Immune Function In The Senior Horse, Alisa Christina Herbst

Theses and Dissertations--Veterinary Science

Senior horses (≥ 15 years) represent up to one-third of the global equine population, and the proportion of old horses (≥ 20 years) in the U.S. has been steadily increasing. Aging is associated with a loss of skeletal muscle mass in horses, and while age-related muscle loss is comparingly well characterized in humans, little is currently known concerning underlying mechanisms, adverse outcomes, or the prevalence of low muscle mass in senior horses. One factor proposed to play a role in the development of age-related muscle atrophy in humans is inflamm-aging, a low-grade inflammation that affects elderly people and that has …

Characterization Of The Metabolic And Cognitive Features Of A Novel Alzheimer’S Disease Rat Model Along With Investigation Of Its Gut Microbiota Change Over Time, Akash Nagarajan

All ETDs from UAB

Alzheimer’s disease (AD) is currently the fifth highest cause of death in the United States and affects primarily individuals of very old age (>80 yrs.). Aging is known to be the biggest risk factor of AD. Recent studies have shown that AD patients have an altered gut microbiota composition. To investigate whether the Alzheimer’s disease pathology in the brain could drive gut microbiota changes during the adult and late life stage of the rat, we performed 16S ribosomal RNA sequencing on the fecal samples of the animals at 14 months and 20 months of age. We found a distinctive …

Primary Care Physicians’ Attitudes, Beliefs, And Actions Toward Geriatric Treatment, Andrea Renee Holzner

Walden Dissertations and Doctoral Studies

AbstractIn the United States, an estimated 49.2 million older adults seek specialized geriatric medical treatment from a primary care physician (PCP). Due to a nationwide geriatrician deficit resulting from significant aging population growth, PCPs now manage specialized geriatric issues, such as Alzheimer’s disease, cognitive assessments, and physiological impairments, such as Parkinson’s, due to non-normative aging. Although PCPs may take geriatric courses, geriatric specialization is beyond a normative primary care medical practice. The purpose of this generic qualitative study was to explore primary care physician attitudes, beliefs, and actions, toward geriatrics and to expand the understanding of primary care physicians’ geriatric …

Evaluation Of The Livewell Method: Final Report, Paula Carder, Serena Hasworth, Diana Cater

Institute on Aging Publications

The LiveWell Method uses a practice-based framework to improve the quality of life for people living and working in long-term care settings, including assisted living and memory care. It is designed to improve teamwork, communication, and morale by helping staff organize, track, measure, and improve daily operations. This evaluation is informed by the LiveWell Method’s “bottom-up and top enabled” approach, which engages and empowers direct care staff and administrators to create a more democratic and transparent workplace. In addition, the evaluation included questions to assess LiveWell’s core values, such as creating care innovations, nurturing dignity, creating community, and honoring elders, …

The Validation Of Predicted Biological Age Of Drosophila Melanogaster From Combined Statistical Modeling, Lauren Francis

Masters Theses

"Sleep is essential for maintaining a healthy body and mind and is associated with aging and aging related diseases. There are individual differences in fly as well as human sleep behavior and lifespan. Between and within individuals, sleep varies in characteristics including consolidation, rhythmicity, continuity, duration, and more. Various evidence in the literature suggests there are many molecular pathways involved with aging and they may be different for individuals. Our research is interested in a possible restorative mechanism of sleep and the ramifications of that mechanism to aging. We have developed two predictive models of aging using the fruit fly …

Dietary Regulation Of Successful Aging, Aubree L. Hawley

Graduate Theses and Dissertations

The current growth of the older population is unprecedented in U.S. history. Chronic disease and functional limitation commonly develop prior to old age, leading to prolonged physical disability and decreased well-being. The development of chronic disease and loss of independence is associated with lean body mass (LBM) loss and fat mass gain beginning in middle age. Therefore, it is important to identify modifiable factors to mitigate deleterious shifts in body composition to promote successful aging (SA). The concept of SA is associated with longevity, the absence of disease and disability, and subjective components of well-being, however, an operational definition has …

“We Never Graduate From Care Giving Roles”; Cultural Schemas For Intergenerational Care Role Among Older Adults In Tanzania, Sylivia Karen Rutagumirwa, Inge Hutter, Ajay Bailey

Open Access archive

This paper examines the cultural schemas underlying older persons’ perception of intergenerational care roles. Thirty qualitative in-depth interviews and twenty focus group discussions (N = 120) were conducted among older women and men aged 60 and above. By using this theory, we were able to identify a series of cultural schemas found in older people’s discussions of intergenerational caregiving role. The most prominent shared schemas are; caregiving for elderly is a cultural obligation not a choice, caregiving is a sign of respect, caregiving is a sign of love, caregiving is a source of pride, and caregiving leads to attachment and …

Implementation Of A Fall Risk Assessment Tool In Primary Practice May Decrease Fall Frequency In The Aging Population, Regina M. White

Doctoral Dissertations and Projects

The purpose of this evidence-based project was to illustrate the benefits of utilizing a fall risk assessment tool during office visits for the aging population of a Midwestern U.S. primary care practice. Utilization of this tool helped minimize fall frequency, thus improved quality of health. The reduction in falls helped minimize unnecessary healthcare expenses. This manuscript identified a rationale for the project, specific tool utilization, outcome measures before and after implementation, limitations, and future application for practice. Provider compliance with tool utilization and frequency were measured. Multiple potential causes of falls and recommendations to minimize falls were identified with the …

Envisioning An Age-Friendly Norwood, Caitlin Coyle, Beth Rouleau

Center for Social and Demographic Research on Aging Publications

Nestled just outside the I-95 beltway, the Town of Norwood, Massachusetts is a community southwest of Boston that takes pride in the history of residents staying in, or returning to, the community across the lifespan. Projections indicate that by 2035, about one out of three Norwood residents will be age 60 or older—24% of the Town’s population will be between the ages of 60 and 79, with an additional 8% age 80 and older (see Appendix A). The desire to stay and a growing older adult population lends to many multi-generational families within the community, creating a sense of supportive …

Gait Complexity Is Acutely Restored In Older Adults When Walking To A Fractal-Like Visual Stimulus, Joao R. Vaz, Brian Knarr, Nicholas Stergiou

Journal Articles

Typically, gait rehabilitation uses an invariant stimulus paradigm to improve gait related deficiencies. However, this approach may not be optimal as it does not incorporate gait complexity, or in more precise words, the variable fractal-like nature found in the gait fluctuations commonly observed in healthy populations. Aging which also affects gait complexity, resulting in a loss of adaptability to the surrounding environment, could benefit from gait rehabilitation that incorporates a variable fractal-like stimulus paradigm. Therefore, the present study aimed to investigate the effect of a variable fractal-like visual stimulus on the stride-to-stride fluctuations of older adults during overground walking. Additionally, …

Social Isolation: Do Helpers Help Ward It Off?, Kirsten Young Brown

MA Research Paper

Social isolation is particularly relevant among elderly individuals who are more likely to need care and help with their physical and living needs. Little is known about whether receiving help correlates with social isolation in older adults living at home as often there is no focus from caregivers and helpers on older adults' social needs. Using data from the 2018 US National Health and Aging Trends Study, a sample of adults aged 65 plus on Medicare/Medicaid (N=4,321), I examine the relationship between social isolation and help. I estimate ordinary least squares regression models to test the association between receiving help …

Age-Related Changes In Repetition Suppression Of Neural Activity During Emotional Future Simulation, Aleea L. Devitt, Preston P. Thakral, Karl Szpunar, Donna Rose Addis, Daniel L. Schacter

Psychology: Faculty Publications

Despite advances in understanding the consequences of age-related episodic memory decline for future simulation, much remains unknown regarding changes in the neural underpinnings of future thinking with age. We used a repetition suppression paradigm to explore age-related changes in the neural correlates of emotional future simulation. Younger and older adults simulated positive, negative, and neutral future events either 2 or 5 times. Reductions in neural activity for events simulated 5 versus 2 times (i.e., repetition suppression) identify brain regions responsive to the specific emotion of simulated events. Critically, older adults showed greater repetition suppression than younger adults in the temporal …

Effects Of An 8-Week Resistance Training Intervention On Plantar Flexor Muscle Quality And Functional Capacity In Older Women: A Randomised Controlled Trial, Pedro Lopez, Brendan James Crosby, Bruna Patrícia Robetti, Douglas Jean Preussler Turella, Thaís Andréia Schepa Weber, Morgana Lima De Oliveira, Anderson Rech

Research outputs 2014 to 2021

The present study examined 8 weeks of resistance training and its effects on muscle quality measures, plantar flexor muscle strength, muscle thickness and functional capacity in older women. Moreover, we tested if changes in muscle quality were associated with functional capacity. Twenty-four older women (66.3 ± 5.8 years; 69.0 ± 3.0 kg; 25.3 ± 1.4 kg·m−2) were recruited to the study. After completion of the baseline assessment, participants were randomly assigned to either the resistance training (RET, n = 12) or an active control group (CTR, n = 12). Muscle quality was evaluated through muscle echo intensity (MQEI) and specific …

Encounters Between The Elderly And Law Enforcement: An Overview Of Mental Illness, Addictions, Victims And Criminals

Contemporary Southern Psychology

Abstract

The elderly population is growing dramatically throughout the world. Out of this growth comes an increase in the number of encounters between the aged and law enforcement. These encounters occur because of a variety of factors including mental illnesses and addictions. Furthermore, older adults may be victims as evidenced in different forms of abuse such as physical, emotional, or financial abuse. Sadly, some documentation exists that older adults are committing more crimes. Multiple reasons have been postulated for these crimes including poverty, jealousy, and boredom. All of these different situations with the aged have created an increase in the …

Diurnal, Metabolic And Thermogenic Alterations In A Murine Model Of Accelerated Aging, David B. Allison, Guang Ren, Rodrigo A. Peliciari-Garcia, Sobuj Mia, Graham R. Mcginnis, Jennifer Davis, Karen L. Gamble, Jeong A. Kim, Martin E. Young

Kinesiology and Nutrition Sciences Faculty Research

Senescence-Accelerated Mouse-Prone 8 (SAMP8) mice exhibit characteristics of premature aging, including hair loss, cognitive dysfunction, reduced physical activity, impaired metabolic homeostasis, cardiac dysfunction and reduced lifespan. Interestingly, circadian disruption can induce or augment many of these same pathologies. Moreover, previous studies have reported that SAMP8 mice exhibit abnormalities in circadian wheel-running behavior, indicating possible alterations in circadian clock function. These observations led to the hypothesis that 24 h rhythms in behavior and/or circadian clock function are altered in SAMP8 mice and that these alterations may contribute to perturbations in whole-body metabolism. Here, we report that 6-month-old SAMP8 mice exhibit a …

Microrna Gene Expression States Underlying Individual Variation In Aging And Lifespan In Isogenic C. Elegans, Holly Kinser

McKelvey School of Engineering Graduate Student Theses & Dissertations

Average lifespan differs greatly between species, but lifespan among same-species individuals is also highly variable. While much effort has been devoted to uncovering longevity-associated traits and lifespan-extending perturbations in humans and model organisms, how differences in lifespan arise between individuals is unknown. Studies of human identical twins demonstrate that surprisingly little of the variation in lifespan between individuals can be explained by genetics and shared environment. Furthermore, even genetically identical C. elegans reared in highly homogeneous environments display a degree of variability in lifespan similar to that of outbred human populations. Thus, longevity must be determined at least in part …

Iot-Enabled Eldercare Technology, Watchanan Chantapakul

International Programs

The world’s population is changing as people are growing older. Leveraging technology for eldercare is important in this century. It can enable many eldercare applications effectively.

Working Beyond 80: The Meaning Of Work To An Octogenarian In The Workforce, Ma. Mayla Imelda M. Lapa, Laurence L. Gracia, Endrex P. Nemenzo

Jurnal Keperawatan Indonesia

There is an increasing share of people aged 50 years and over in the labor market structure and the rapid aging of the global workforce that supports the latter claim but with a little tank of information on qualitative research describing the experiences of a working octogenarian. An octogenarian is a person who is between 80 and 89 years old. This study aimed to investigate the experiences of a working octogenarian in her fieldwork through a qualitative case study analysis. From the interview, the following three themes were revealed: (a) Work as a legacy, (b) Work as an advocacy, and …

Give 5 Gives Back: Assessment Of A New Civic Matchmaking Program For Older Adults, Gloria J. Galanes, Bradley J. Fisher

eJournal of Public Affairs

This study assessed participants’ responses to the Give 5 Program, a civic matchmaking program where volunteers learn about and are encouraged to volunteer at local nonprofits. Participants were also asked general questions about successful aging. Of the 83 respondents, who were overwhelmingly positive about the program, 95% had recommended it to others, 81% were volunteering at four hours per week on average, and 57% had given money to one or more agencies. Respondents said the most important characteristics to successful aging were having a purpose, positive interactions with others, good health, the opportunity for personal growth, self-acceptance, and staying active. …

Genetic And Metabolomic Architecture Of Variation In Diet Restriction-Mediated Lifespan Extension In Drosophila., Kelly Jin, Kenneth A. Wilson, Jennifer N. Beck, Christopher S. Nelson, George W. Brownridge Iii, Benjamin R. Harrison, Danijel Djukovic, Daniel Raftery, Rachel B. Brem, Shiqing Yu, Mathias Drton, Ali Shojaie, Pankaj Kapahi, Daniel Promislow

Natural Sciences and Mathematics | Student Professional Publications

In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad libitum (AL) diet, and measured a panel of 105 metabolites under both diets. Twenty four out of 105 metabolites were associated with the magnitude of the lifespan response. These included proteinogenic amino acids and metabolites involved in α-ketoglutarate (α-KG)/glutamine metabolism. We confirm the role of α-KG/glutamine synthesis pathways in the DR response through genetic …