Digital Commons Network^™

Disease Burden Affects Aging Brain Function, Lori L Beason-Held, Danielle Fournier, Andrea T Shafer, Elisa Fabbri, Yang An, Chiung-Wei Huang, Murat Bilgel, Dean F Wong, Luigi Ferrucci, Susan M Resnick

2020-Current year OA Pubs

BACKGROUND: Most older adults live with multiple chronic disease conditions, yet the effect of multiple diseases on brain function remains unclear.

METHODS: We examine the relationship between disease multimorbidity and brain activity using regional cerebral blood flow (rCBF) 15O-water PET scans from 97 cognitively normal participants (mean baseline age 76.5) in the Baltimore Longitudinal Study of Aging (BLSA). Multimorbidity index scores, generated from the presence of 13 health conditions, were correlated with PET data at baseline and in longitudinal change (n = 74) over 5.05 (2.74 SD) years.

RESULTS: At baseline, voxel-based analysis showed that higher multimorbidity scores were associated …

Gradient And Acceleration Of Decline In Physical And Cognitive Functions In Older Adults: A Disparity Analysis, H. Ip Edward, Shyh Huei Chen, W. Jack Rejeski, Karen Bandeen-Roche, Kathleen M. Hayden, Christina E. Hugenschmidt, June Pierce, Michael E. Miller, Jaime L. Speiser, Stephen B. Kritchevsky, Denise K. Houston, Robert L. Newton, Stephen R. Rapp, Dalane W. Kitzman

Population and Public Health Science Faculty Publications

Background: Substantive previous work has shown that both gait speed and global cognition decline as people age. Rates of their decline, as opposed to cross-sectional measurements, could be more informative of future functional status and other clinical outcomes because they more accurately represent deteriorating systems. Additionally, understanding the sex and racial disparity in the speed of deterioration, if any, is also important as ethnic minorities are at an increased risk of mobility disability and dementia. Method: Data from 2 large longitudinal intervention studies were integrated. Rates of decline were derived from individual-level measures of gait speed of 400-m walk and …

Passive Remote Monitoring And Aging In Place: A Scoping Review, Emily Read, Cora Woolsey, Lorie Donelle, Lori Weeks, Norma Chinho

Publications

Passive remote monitoring is a relatively new technology that may support older adults to age in place. However, current knowledge about the effectiveness of this technology in extending older adults' independence is lacking. Therefore, we conducted a scoping review of studies examining passive remote monitoring to systematically synthesize evidence about the technology's effectiveness as an intervention. Our initial search of Embase, CINAHL, PubMed, and Scopus databases identified 486 unique articles. Of these, 14 articles met our inclusion criteria. Results show that passive remote monitoring technologies are being used in innovative and diverse ways to support older adults aging in place …

Does Well-Being Moderate The Association Of Harm Avoidance With Cognitive Decline, Christopher Reed

LSU Master's Theses

The Dual-Factor Model of mental health highlights the need to consider both constructs associated with psychopathology and subjective well-being in relation to clinical outcomes. Harm avoidance, which is associated with behavioral inhibition, has been negatively associated with cognitive change. While subjective well-being has been positively associated with cognition. The current study aimed to examine both constructs in a single model to examine well-being as a moderator of the association of harm avoidance with cognitive decline. A sample of 728 older adults from the Rush University Memory and Aging Project was used. Participants completed batteries of questionnaires and neuropsychological tests at …

The Regulation Of Oxidative Stress In Age-Related Diseases, Jesica Burkhart

Theses and Dissertations

Oxidative stress and mitochondrial dysfunction have been linked to multiple age-related diseases including common neurodegenerative diseases Alzheimer's disease (AD) and Parkinson’s disease (PD). A gene found to regulated oxidative stress and aging is a stress response gene p38 MAPK (p38K). Oxidative stress arises when the over production of reactive oxygen species (ROS) from within the cell or from environmental stimuli outweighs its clearance by antioxidants. This cascade leads to DNA damage, mitochondrial damage, and cell death. Mitochondrial dysfunction and oxidative stress are markers for biological aging. As we age mitochondrial DNA becomes more sensitive to damages and mutations. When the …

The Experiences Of Older Formerly Incarcerated Adults In A Specialized Reentry Program During The Covid-19 Pandemic, Robin O'Hanlon, Jessica Broome

Publications and Research

A growing area of concern among prison reform advocates and human rights activists is the “greying prison population” or the continuous, unified growth in the number of older incarcerated individuals. Older individuals experience an accelerated aging process while incarcerated, but are less likely to reoffend upon release. While the aging prison population has in recent years become a focus of criminological and gerontological scholars, the lived experience of older formerly incarcerated individuals during the reentry process remains understudied. Using a qualitative approach, this cohort study seeks to further elucidate the unique needs, beliefs, and perceptions of this population within the …

Examining The Effects Of Passenger Conversation On Older Adult Driving, Allison Green, Meg Tedder, Amanda J. Mohler, Amanda M. Carpenter

Student Journal of Occupational Therapy

Older adults have impaired driving performance compared to other age groups, and auditory stimuli has adverse effects on driving performance (Karthaus & Falkenstein, 2016). Therefore, the purpose of this study was to expand knowledge of driving and passenger conversation within the older adult population. Participants (n = 17) completed a drive of 7.8 miles on a driving simulator twice; once without conversation and again with conversation. Both drives used the same simulated driving tasks to examine driving performance with and without conversation. Participants exhibited poorer driving performance from the first drive without conversation to the second drive with conversation, …

"Queering" Age-Friendly New York City, Austin G. Oswald

Dissertations, Theses, and Capstone Projects

Background and aims: The global population is aging and becoming more culturally diverse. As such, scholars, practitioners, and policymakers are expected to think critically about strategies to improve the quality of life of people as they age. In 2007, the World Health Organization (WHO) launched the Age-Friendly Cities movement to improve the well-being and meaningful engagement of older adults living in the community. New York City (NYC) was the first city in the world to be designated “age-friendly” by the WHO, and is possibly viewed as a model for other cities to emulate. Few empirical studies have examined the age-friendly …

Aging In Lynn: A Community Needs Assessment, Caitlin Coyle, Mary Krebs, Setarreh Massihzadegan

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the City of Lynn and the Lynn Department of Elder Services. The goals of this project were to investigate the needs, interests, preferences, and opinions of residents of the City of Lynn age 60 or older. The contents of this report are meant to inform the planning and operation of the Lynn Senior Center, and organizations that work with and on behalf of older residents of the City of Lynn. The report …

The Role Of Physical Activity And Gender As Moderators For The Relationship Between Insomnia And Depression, Claire E. Wickersham

Graduate Doctoral Dissertations

Objective: The aim of this study was to examine the association between insomnia and depressive symptoms among middle-aged and older adults and to investigate whether gender or physical activity moderates this relationship. Method: This study used nationally representative data from the 2016 and 2018 waves of the Health and Retirement Study (HRS) and binomial logistic regression was used to estimate models. Regression models for risk of depressive symptoms (2018) were based on a longitudinal model with time-lagged indicators of insomnia, levels of physical activity, and covariates (2016). Results: Analyses showed that participants who reported having insomnia in 2016 were more …

Techniques To Analyze The Pathophysiology Of Aging From Induced Senescence And Sod2 Loss, Asia Davis-Castillo

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Cardiovascular disease is the leading cause of death in the United States. Cardiac function declines with age, and promotes a number of age-related disorders, including atrial fibrillation and heart failure. Mitochondrial oxidative stress has long been suspected as a primary driver of aging pathology in multiple tissues, including the heart and brain. We used several phenotypic assays to characterize chemically-induced accelerated cardiac aging, as well as two transgenic knockout models for heart and brain specific loss of superoxide dismutase (SOD2), a mitochondrial antioxidant protein.

We first accelerated aging in mice by treating with doxorubicin (DOXO), a chemotherapeutic drug. One group …

Exploring The Diet Dependent Role Of Oxidation Resistance 1 In Regulating Retromer Function, Enrique Carrera

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Aging has been identified as a significant risk factor to the development of several diseases, such as neurodegeneration¹. One of the most common age-related neurodegenerative diseases is Alzheimer’s Disease (AD)², which causes cognitive decline. Current treatments for AD attempt to mitigate its symptoms or delay its onset^3–5. One method that has shown promise not only for the treatment of AD, but also for increasing lifespan and healthspan overall is dietary restriction (DR)⁶, but the mechanisms by which DR mediates these effects remains unclear^7,8. We have identified the human gene Oxidation …

Micro-Computed Tomography Assessment Of Bone Structure In Aging Mice, Junbo Shim, Chihiro Iwaya, Catherine G Ambrose, Akiko Suzuki, Junichi Iwata

Faculty, Staff and Student Publications

High-resolution computed tomography (CT) is widely used to assess bone structure under physiological and pathological conditions. Although the analytic protocols and parameters for micro-CT (μCT) analyses in mice are standardized for long bones, vertebrae, and the palms in aging mice, they have not yet been established for craniofacial bones. In this study, we conducted a morphometric assessment of craniofacial bones, in comparison with long bones, in aging mice. Although age-related changes were observed in the microarchitecture of the femur, tibia, vertebra, and basisphenoid bone, and were more pronounced in females than in males, the microarchitecture of both the interparietal bone …

Targeting The Needs Of Aging Lgbtq+: Addressing Barriers To Healthcare Access, Susan Wiley, Danielle Lachance

Thinking Matters Symposium

This research project aims to gather further insight of challenges aging LGBTQ+ individuals face while accessing healthcare; specifically nursing care facilities in the state of Maine. This is an exploratory pilot study that used mixed methods of quantitative survey questions and included open-ended questions. The researchers used a nonrandom, purposive sampling of LGBTQ+ individuals aged 65+ who are accessing residential nursing care, nursing care facility staff members, and family members of LGBTQ+ actively or previously in residential care facilities. For the purpose of this research project “healthcare services'' will refer specifically to residential nursing care facilities. Prior research indicates aging …

Leveraging Public-Private Partnerships During Covid-19: Providing Virtual Field Opportunities For Student Learners And Addressing Social Isolation In Older Adults, Omolola E. Adepoju, Sheara Jennings, Patti Schrader, Kathleen Reeve, Tracy Mcmanaman-Bridges, Lauren Gilbert, Ben King, Jessica Dobbins, Andy Rollins, Luis R. Torres-Hostos

School of Social Work Faculty Publications

While preventive and management measures are important to mitigate the spread of COVID-19, strategies like social distancing can have devastating effects on older adults who are already at risk for social isolation and loneliness. In response, two Colleges of Health Professions (Social Work and Nursing) at a large public University leveraged a partnership with a national health and wellbeing company to address social isolation and loneliness in Houston area older adults during the COVID-19 pandemic. This intergenerational linkage initiative involved 707 older adults and 177 graduate social work and nursing students. This study describes the process of developing a virtual …

Aging In Hull: A Community Needs Assessment, Caitlin Coyle, Beth Rouleau

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Hull Council on Aging. The goals of this project were to investigate the needs, interests, preferences, and opinions of Hull’s residents age 55 or older. The contents of this report are meant to inform the Town of Hull, the Hull Council on Aging and Senior Center, and organizations that work with and on behalf of older residents of Hull for the purposes of planning and coordination of services. The report will …

Aging In Hull: A Community Needs Assessment, Caitlin Coyle, Beth Rouleau

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Hull Council on Aging. The goals of this project were to investigate the needs, interests, preferences, and opinions of Hull’s residents age 55 or older. The contents of this report are meant to inform the Town of Hull, the Hull Council on Aging and Senior Center, and organizations that work with and on behalf of older residents of Hull for the purposes of planning and coordination of services. The report will …

Most Home-Delivered Meal Recipients With Dementia Receive Support From Friends And Family, But More Social Activity Is Needed, Claire Pendergrast

Population Health Research Brief Series

Home-delivered meal programs reduce hunger and food insecurity, promote socialization, and improve health and wellbeing for older adults. Regular social support from home-delivered meal drivers, alongside social support from friends and family, may be key to preventing isolation and improving health for older adults with dementia. This research brief shows that home-delivered meal recipients with dementia receive significant support from friends and family, but 83% would like more social activity. To better support older adults with dementia and family caregivers, aging services providers should expand virtual and dementia-friendly social engagement programming.

Views On Aging – Current Trends And Future Directions For Cross-Cultural Research, Anna E. Kornadt, Clara De Paula Couto, Klaus Rothermund

Online Readings in Psychology and Culture

The investigation of what enables societies and individuals to age well remains one of the greatest challenges of our time. Views on aging are a decisive factor in this process, and thus, improving their understanding through cross-cultural research is of utmost importance. In the current review, we address the role of socio-ecological variables and cultural values and beliefs when investigating country differences in what people think about older persons and getting old themselves. Several complexities are introduced in terms of a differentiated conceptualization of views on aging that takes life domains and normative prescriptions into account, and also in terms …

Aging And Disability Services Are Unequally Distributed Across The United States, Claire Pendergrast, Danielle Rhubart

Population Health Research Brief Series

As the U.S. population ages, demand for aging and disability services will increase, but 15% of U.S. counties have no aging and disability services organizations. This brief shows that rural counties and counties with the highest rates of poverty, highest shares of older adults, and highest shares of non-Hispanic Blacks are most likely to be aging and disability services deserts. To support healthy aging across the country, policymakers should invest in aging services infrastructure and should prioritize resources for places that are aging and disability services deserts.

Support From Adult Children And Parental Health In Rural America, Shelley Clark, Elizabeth M. Lawrence, Shannon M. Monnat

Journal of Rural Social Sciences

Adult children are a primary source of care for their aging parents. Parents in rural areas, however, live further from their adult children than parents in urban areas, potentially limiting the support they receive and compromising their health and ability to age in place. We use two waves of the Panel Study of Income Dynamics (2013 and 2017) to investigate the relationships among geographic proximity, adult children’s instrumental and financial support, and parental health. Rural parents live further from their adult children and receive less financial support, but they are more likely to receive instrumental assistance. In addition, rural parents …

Rural Population Health And Aging: Introduction To The Special Issue, John J. Green, Shannon M. Monnat, Leif Jensen, Lori Hunter, Martin Sliwinski

Journal of Rural Social Sciences

This special issue of the Journal of Rural Social Sciences (JRSS) focuses on rural population health and aging. It showcases the work of scholars from several backgrounds and social science disciplines to advance knowledge in a critical field of investigation. Assembled through an open call for submissions coordinated through the National Institute on Aging (NIA) funded Interdisciplinary Network on Rural Population Health and Aging (INRPHA), the collection of articles helps inform a more nuanced understanding of the factors associated with rural places, which often have different health outcomes and aging patterns than their urban counterparts. The authors achieve this through …

The Impact Of Aging On The Lung Alveolar Environment, Predetermining Susceptibility To Respiratory Infections, Jordi B. Torrelles, Blanca I. Restrepo, Yidong Bai, Corinna Ross, Larry S. Schlesinger, Joanne Turner

School of Medicine Publications

Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.

Encounters Between The Elderly And Law Enforcement

Contemporary Southern Psychology

The elderly population is growing dramatically throughout the world. Out of this growth comes an increase in the number of encounters between the aged and law enforcement. These encounters occur because of a variety of factors including mental illnesses and addictions. Furthermore, older adults may be victims as evidenced in different forms of abuse such as physical, emotional, or financial abuse. Sadly, some documentation exists that older adults are committing more crimes. Multiple reasons have been postulated for these crimes including poverty, jealousy, and boredom. All of these different situations with the aged have created an increase in the number …

Mobility Of Older Adults In Mexico City: A Mixed Methods Approach, Jessica Villena Sanchez

Electronic Theses and Dissertations

This dissertation covers the topic of the mobility of older adults in Mexico City using a mixed methods approach. First, I looked at the literature to uncover what is known about elderly mobilities coming from the Global South. Second, I analyzed the 2017 Household Origin Destination Survey to reveal travel behavior patterns and transport mode choice of older adults in Mexico City. Third, I revealed mobility experiences from older adults living in different neighborhoods in Mexico City by conducting twenty two telephone interviews. Lastly, I created joint displays that included both previous results to better understand how the findings from …

Attitudes And Perceptions Of Nursing Graduates Regarding Interest In Gerontological Nursing Practice, Sonia Millicent Donaldson

Walden Dissertations and Doctoral Studies

AbstractAn ongoing increase in the number of older adults means an increased need for specialized health care, creating, in turn, a need for an increase in nurses in the United States to meet the demand. However, there is a problem in that nursing graduates, from the time they are students, do not choose geriatric-gerontological nursing (GN) as is practiced in long-term care and some specialty areas or units. The purpose of this basic qualitative study was to explore nursing graduates’ perceptions of GN as a field for professional practice and to determine how interest in GN may be encouraged. The …

Effect Of Living Arrangements On Cognitive Function In Chinese Elders: A Longitudinal Observational Study, Yanwei Lin, Qi Zhang, Tingxian Wang, Zhirong Zeng

Community & Environmental Health Faculty Publications

Objective To examine how living arrangement as a social contextual factor can affect Chinese elders’ cognitive function.

Setting and participants Our sample consists of 2486 Chinese elders from two waves (2014 and 2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) that was administered in 22 of China’s 31 provinces using a multi-stage, disproportionate, purposive random sampling method. The CLHLS aims to better understand the determinants of healthy longevity in China and collects extensive data on a large population of fragile elders aged 80–112 in China.

Outcome measures Cognitive function was measured by the Mini-Mental State Examination (MMSE). Living arrangement …

Perceived Physical Fatigability Predicts All-Cause Mortality In Older Adults, Nancy W. Glynn, Theresa Gmelin, Sharon W. Renner, Yujia Susanna Qiao, Robert M. Boudreau, Mary F. Feitosa, Mary K. Wojczynski, Stephanie Cosentino, Stacy L. Andersen, Kaare Christensen, Anne B. Newman

Open Access Publications

BACKGROUND: Perceived physical fatigability is highly prevalent in older adults and associated with mobility decline and other health consequences. We examined the prognostic value of perceived physical fatigability as an independent predictor of risk of death among older adults.

METHODS: Participants (N = 2 906), mean age 73.5 [SD, 10.4] years, 54.2% women, 99.7% white enrolled in the Long Life Family Study, were assessed at Visit 2 (2014-2017) with 2.7 [SD, 1.0] years follow-up. The Pittsburgh Fatigability Scale (PFS), a 10-item, self-administered validated questionnaire (score range 0-50, higher = greater fatigability) measured perceived physical fatigability at Visit 2. Deaths post-Visit …

Population Dynamics And Seasonal Movements Of Blue Suckers (Cycleptus Elongatus) In The James River, South Dakota, Tanner Leigh Carlson

Dissertations and Theses

Blue Suckers are a declining long lived catostomid, native to the large rivers and tributaries of the central United States. Currently in decline throughout their range due to anthropogenic impacts such as river channelization and dam construction, there are few stable Blue Sucker populations remaining. This study sought to describe population demographics of a stable population of Blue Suckers located in the unchannelized reach of the Missouri River below Gavins Point Dam. Year class strength, growth, and natural mortality was estimated based on aging data collected from lapillus otoliths. Previous research was conflicting as to what aging structure, pectoral fin …

A Mixed Methods Study On Levels Of Physical Activity And Degree Of Fear Of Falling In Older Adults, Oscar L. Garcia

Honors Undergraduate Theses

Maintaining a physically active lifestyle has shown to decrease the risks of falling by slowing down the degenerative changes that occur with aging adults. But despite these physical changes, research has recognized the development of the fear of falling (FOF) as also attributing to the aging adults’ risk of falling. Furthermore, increases the risk of falling and subsequently increases the loss of independency. This study aimed to: 1) examine the relationships between the levels of physical activity, degree of FOF, and fall risk using quantitative approach; and 2) explore the changes of FOF and understand its cause using qualitative approach. …