Digital Commons Network^™

Chronic Illness Education 2022: Addressing Common Causes Of Hypertension In The Detroit Adult Population, Kassandra Solrud, Crisshy Auguste, Kayvon Sanjasaz, Matthew Zabat, Rana Khamis, Soham Desai, Zeynoire Anderson

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Diabetes Mellitus Education For Adults In Southeast Michigan, Muhammad Ahmed, Ahmad Kofahi, Caleb Richard, Hadi El Ammar, Huda Warsame, Janice Gibbons, Jodene Takahashi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Hypertension In Adults, Ahmad El-Moussa, Bhavana Garapati, Jhonny Lopez, Mariam Abdelmesih, Matthew Hansen, Omar Abbas, Shreya Balusu

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Adult Hiv Prevention, Screening, And Treatment, Mohamad Almujarkesh, Lillian Baumann, Michael Escobar, Michael Melhem, Nicholas Pryde, Quynh Nguyen (Liu), Victoria Kelley

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Heart Disease: Ways Of Combating The Silent Killer, Amer Tamr, Alexander Wind, Alexandra Breves, Brandon Holland, Coltrane Groves, Mina Juma, Sydney Colbert

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Food Choices Made Easy: Eating Well With Ckd, Arqam Husain, Amir Kalantar, Ismail Aijazuddin, Nada Jaradat, Raisa Zahir, Rubab Imtiaz, Tristan Papcun

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Helping Patients Access Low-Cost Diabetes Supplies And Medications, Iyanna Peppers, Laial Baltaji, Lucas Edgren, Lyndsay Archer, Molly Wilson

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Managing Chronic Kidney Disease With Exercise, Kelsey Trulik, Adlai Nelson, Arsh Kaiser, Chelsea Yu, Collin Gustafson, Erin Madden, Matthew Myhand

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Prevention Of High Blood Pressure In Adult Populations, Gabrielle Barthel, Allison Boland, Alyssa Dsouza, Hassan Ahmad, Nicholas Zura, Samuel Grand, Sreenavya Gandikota

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Chronic Obstructive Pulmonary Disease, Teresa Alfauhernandez, Ajith Dupati, Daniel Settecerri, Elsa Nylund, Leah Warren, Unie Gu

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: A Recipe For Healthy Living, Awad Maria, Andrew Gregory, Andrew Rabah, Kia Sweeney, Laura Aravena, Nicholas Livingston, Tabassum Chowdhury

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Increasing Education About Depression And Anxiety Among Middle Aged Men, Rebecca White, Amanda Paskavitz, Andrew Demko, Christelle Wharram, Eli Tanenbaum, Jennifer Schmidt, Justin Bennie

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Improving Support For Young Adult Women Suffering From Suicidal Ideation, Rebecca White, Colt Maccaughan, Cristian Diaz Alvarenga, Hannah Michelakis, Samuel Goorman, Soumeeka Koneru, Victoria Qian

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Type Ii Diabetes Management In Adults: Medications And Community Resources, Varag Abed, Camila Arellano, Carolyn Baldwin, Ethan Ervin, Haya Beydoun, Mahnoor Ayub, Yoshio Wagner

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Removing Barriers To Hiv Screening For At-Risk Young Adults In Metro Detroit, Lauren Smith, Aila Rahman, Amanda Stevens, Kenan Sinan, Ryan Nazareno, Tara Hekmati

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Week In The Life Of Heart Health, Rebecca Schultz, Bria Elrod, Jacfar Hassan, Julia Chase, Keinnan Hares, Sadaf Hashemian

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Increasing Hiv Knowledge And Awareness Of The Young Adult Population In The Local Detroit Community, Rachel Monconduit, Catherine Bogolawski, Haniyeh Zamani, Joshua Kirschner, Logan Thayer, Matthew Corsi, Samantha Pfiffner

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Lifestyle Tips For Managing Hypertension, Amer Tamr, Andranig Adjemian, Erika Lopez, Jack Considine, Jordan Akins, Madeline Simone, Younes Motii

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Diabetes Management In Adults In The Detroit Area, David Asebiode, Chase Morrison, Erin Bybee, Isaiah Hough, Madison Graifman, Mehrnoosh Ghafouri Abbasabadi, Saranya Madan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Encouraging Adherence To Antihypertensive Medications Among An Adult Population, Tyler Mumm, Alexis Malecki, Benjamin Sliwinski, Ehsan Noori, Logan Nguyen, Neil Patel, Rana Elhamzawy

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Prevention And Prevalence Of Depression Among Medical Students And Residents, Brandon Batarse, Aarti Patel, Husain ​Al Saffar, Kathleen Young, Matthew Brennan, Sabrina Montemayor, Shobi Mathew

Patient Education Projects

No abstract provided.

Trial Of Antisense Oligonucleotide Tofersen For Sod1 Als, Timothy M Miller, Robert C Bucelli, Et Al.

2020-Current year OA Pubs

BACKGROUND: The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated with mutations in

METHODS: In this phase 3 trial, we randomly assigned adults with

RESULTS: A total of 72 participants received tofersen (39 predicted to have faster progression), and 36 received placebo (21 predicted to have faster progression). Tofersen led to greater reductions in concentrations of SOD1 in CSF and of neurofilament light chains in plasma than placebo. In the faster-progression subgroup (primary analysis), the change to week 28 in the ALSFRS-R …

Amino Acids, Microbiota-Related Metabolites, And The Risk Of Incident Diabetes Among Normoglycemic Chinese Adults: Findings From The 4c Study, Shuangyuan Wang, Mian Li, Hong Lin, Guixia Wang, Yu Xu, Xinjie Zhao, Chunyan Hu, Yi Zhang, Ruizhi Zheng, Ruying Hu, Lixin Shi, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Ruixin Liu, Xiaolin Wang, Qi Li, Guijun Qin, Qin Wan, Gang Chen, Min Xu, Meng Dai, Di Zhang, Xulei Tang, Zhengnan Gao, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yiming Mu, Lulu Chen, Donghui Li, Guowang Xu, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu

Faculty, Staff and Student Publications

Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs and 22 MRMs in 3,414 subjects with incident diabetes and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic AAs, asparagine, alanine, glutamic acid, homoserine, 2-aminoadipic acid, histidine, methionine, and proline are positively associated with incident T2DM. In the MRM panel, serum carnitines, N-acetyltryptophan, and uric acid are positively associated with …

Body Size At Different Ages And Risk Of 6 Cancers: A Mendelian Randomization And Prospective Cohort Study, Daniela Mariosa, Karl Smith-Byrne, Tom G Richardson, Pietro Ferrari, Marc J Gunter, Nikos Papadimitriou, Neil Murphy, Sofia Christakoudi, Konstantinos K Tsilidis, Elio Riboli, David Muller, Mark P Purdue, Stephen J Chanock, Rayjean J Hung, Christopher I Amos, Tracy A O'Mara, Pilar Amiano, Fabrizio Pasanisi, Miguel Rodriguez-Barranco, Vittorio Krogh, Anne Tjønneland, Jytte Halkjær, Aurora Perez-Cornago, María-Dolores Chirlaque, Guri Skeie, Charlotta Rylander, Kristin Benjaminsen Borch, Dagfinn Aune, Alicia K Heath, Heather A Ward, Matthias Schulze, Catalina Bonet, Elisabete Weiderpass, George Davey Smith, Paul Brennan, Mattias Johansson

Staff and Researcher Publications

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in …

The Core Rehabilitation Outcome Set For Single-Sided Deafness (Crosssd) Study: International Consensus On Outcome Measures For Trials Of Interventions For Adults With Single-Sided Deafness, Roulla Katiri, Deborah A Hall, Derek J Hoare, Kathryn Fackrell, Adele Horobin, Nicholas Hogan, Nóra Buggy, Paul H Van De Heyning, Jill B Firszt, Iain A Bruce, Pádraig T Kitterick, Core Rehabilitation Outcome Set For Single-Sided Deafness (Crosssd) Initiative

2020-Current year OA Pubs

BACKGROUND: Single-sided deafness (SSD) has functional, psychological, and social consequences. Interventions for adults with SSD include hearing aids and auditory implants. Benefits and harms (outcome domains) of these interventions are until now reported inconsistently in clinical trials. Inconsistency in reporting outcome measures prevents meaningful comparisons or syntheses of trial results. The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) international initiative used structured communication techniques to achieve consensus among healthcare users and professionals working in the field of SSD. The novel contribution is a set of core outcome domains that experts agree are critically important to assess in all clinical …

Persistent Disparities In Colorectal Cancer Screening: A Tell-Tale Sign For Implementing New Guidelines In Younger Adults, Po-Hong Liu, Nina N Sanford, Peter S Liang, Amit G Singal, Caitlin C Murphy

Faculty, Staff and Student Publications

BACKGROUND: In May 2021, the U.S. Preventive Services Task Force began recommending initiating colorectal cancer screening at age 45 (vs. 50) years.

METHODS: We estimated prevalence of colorectal cancer screening (by colonoscopy, sigmoidoscopy, CT colonography, or stool-based tests) in adults ages 50 to 75 years using data from the National Health Interview Survey in 2000, 2003, 2005, 2008, 2010, 2013, 2015, and 2018. For each survey year, we estimated prevalence by age, race/ethnicity, educational attainment, family income, and health insurance. We also compared increases in prevalence of screening from 2000 to 2018 in 5-year age groups (50-54, 55-59, 60-64, 65-69, …

Preoperative Inflammatory Markers As Prognostic Predictors After Hepatocellular Carcinoma Resection: Data From A Western Referral Center, João Paulo Maciel Silva, Fabricio Ferreira Coelho, Alex Jones Flores Cassenote, Vagner Birk Jeismann, Gilton Marques Fonseca, Jaime Arthur Pirola Kruger, José Donizeti De Meira Júnior, Sérgio Carlos Nahas, Paulo Herman

Faculty, Staff and Student Publications

BACKGROUND: Recent studies from eastern centers have demonstrate an association between inflammatory response and long-term outcomes after hepatocellular carcinoma (HCC) resection. However, the prognostic impact of inflammatory markers in western patients, with distinct tumor and epidemiologic features, is still unknown.

AIM: To evaluate the prognostic impact of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), as well as their impact according to tumor size (< 5 cm, 5-10 cm, > 10 cm) in patients undergoing HCC resection with curative intent.

METHODS: Optimal cut-off values for NLR, PLR, and MLR were determined by plotting the receiver operator curves. Overall survival (OS) and disease-free …

Athletes Perceive Weighted Baseballs To Carry A Notable Injury Risk, Yet Still Use Them Frequently: A Multicenter Survey Study, Austin G. Cross, Lafi S. Khalil, Alexander J. Swantek, Vincent A. Lizzio, Alexander C. Ziedas, Christopher L. Camp, Peter N. Chalmers, Karch Smith, Sarah E. Chaides, John D. Rexroth, Eric C. Makhni

Orthopedics Articles

INTRODUCTION: Weighted baseball use in throwing programs is widespread; however, their use remains controversial. Prior research shows that weighted baseball programs can increase ball velocity but potentially increase throwing arm injuries. This study aims to ascertain perceptions of weighted baseballs among elite baseball players.

METHODS: A created online survey questioned common practices, throwing regimens, injury risk factors, and weighted baseball program use. The questions were modeled to ascertain the perceptions of elite baseball players to understand their experience with weighted baseballs. Descriptive statistical analysis was conducted.

RESULTS: Three hundred seventy-six baseball players with a mean age of 20 ± 2 …

Assessment Of An Intervention To Reduce Aspirin Prescribing For Patients Receiving Warfarin For Anticoagulation, Jordan K. Schaefer, Josh Errickson, Xiaokui Gu, Tina Alexandris-Souphis, Mona A. Ali, Brian Haymart, Scott Kaatz, Eva Kline-Rogers, Jay H. Kozlowski, Gregory D. Krol, Vinay Shah, Suman L. Sood, James B. Froehlich, Geoffrey D. Barnes

Internal Medicine Articles

Importance: For some patients receiving warfarin, adding aspirin (acetylsalicylic acid) increases bleeding risk with unclear treatment benefit. Reducing excess aspirin use could be associated with improved clinical outcomes.

Objective: To assess changes in aspirin use, bleeding, and thrombosis event rates among patients treated with warfarin.

Design, Setting, and Participants: This pre-post observational quality improvement study was conducted from January 1, 2010, to December 31, 2019, at a 6-center quality improvement collaborative in Michigan among 6738 adults taking warfarin for atrial fibrillation and/or venous thromboembolism without an apparent indication for concomitant aspirin. Statistical analysis was conducted from November 26, 2020, to …

Predicting At-Risk Opioid Use Three Months After Ed Visit For Trauma: Results From The Aurora Study, Brittany E. Punches, Uwe Stolz, Caroline E. Freiermuth, Rachel M. Ancona, Samuel A. Mclean, Stacey L. House, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Tanja Jovanovic, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher A. Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Michael C. Kurz, Nina T. Gentile, Meghan E. Mcgrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Anna M. Chang, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven E. Bruce, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, Jordan W. Smoller, Beatriz Luna, Steven E. Harte, James M. Elliott, Ronald C. Kessler, Kerry J. Ressler, Karestan C. Koenen, Michael S. Lyons

Emergency Medicine Articles

OBJECTIVE: Whether short-term, low-potency opioid prescriptions for acute pain lead to future at-risk opioid use remains controversial and inadequately characterized. Our objective was to measure the association between emergency department (ED) opioid analgesic exposure after a physical, trauma-related event and subsequent opioid use. We hypothesized ED opioid analgesic exposure is associated with subsequent at-risk opioid use.

METHODS: Participants were enrolled in AURORA, a prospective cohort study of adult patients in 29 U.S., urban EDs receiving care for a traumatic event. Exclusion criteria were hospital admission, persons reporting any non-medical opioid use (e.g., opioids without prescription or taking more than prescribed …