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Enhancing Cultural Competency Through Training In A Primary Care Clinic, Rogelio Perez Iii Aug 2026

Enhancing Cultural Competency Through Training In A Primary Care Clinic, Rogelio Perez Iii

Doctor of Nursing Practice Projects

Cultural competence remains essential in primary care settings serving diverse populations, yet staff at a small Southern Texas primary care clinic reported no previous formal cultural competency training in workplace orientation or school. The purpose of this Doctor of Nursing Practice quality improvement project was to evaluate whether a brief, evidence-based cultural competency intervention improved clinician cultural competency scores. Madeleine Leininger’s Culture Care Theory provided the theoretical framework, Lewin’s Change Theory guided the change process, and the Plan-Do-Study-Act cycle directed implementation and evaluation. The problem addressed was the lack of structured training to support culturally responsive communication, patient trust, and …


Impacting Competency In C-Ssrs Suicide Risk Screening On An Inpatient Psychiatric Unit, Fidelis Sangye Aug 2026

Impacting Competency In C-Ssrs Suicide Risk Screening On An Inpatient Psychiatric Unit, Fidelis Sangye

Doctor of Nursing Practice Projects

Suicide remains a leading public health concern, and inconsistent application of the Columbia-Suicide Severity Rating Scale (C-SSRS) may contribute to variability in suicide risk assessment and delayed intervention within inpatient psychiatric settings. The purpose of this quality improvement (QI) project was to evaluate the effectiveness of a standardized C-SSRS-guided educational intervention on staff competency in suicide risk screening. Guided by Lewin’s Change Theory and implemented using the Plan-Do-Study-Act (PDSA) framework, this quantitative pretest-posttest QI project was conducted on an adult inpatient psychiatric unit. The intervention consisted of a 25-minute instructor-led PowerPoint presentation on standardized C-SSRS administration and evidence-based suicide risk …


Improving Cpr Quality In The Emergency Department By Implementing Data Driven Debriefs, Alyssa M. Hughes Aug 2026

Improving Cpr Quality In The Emergency Department By Implementing Data Driven Debriefs, Alyssa M. Hughes

Doctor of Nursing Practice Final Project Abstract

Purpose

The purpose of the quality improvement project was to evaluate the effectiveness of implementing a data driven debrief tool to improve the average compressions in target in adult cardio-pulmonary resuscitation (CPR) events.

Results

In FY23 prior to implementation the average compressions in target was only 1.65%. During the implementation phase of the project the average compressions in target reached 41% (n=3). In addition, the staff provided positive feedback regarding the tool and the integration in the workflow.

Background

The project was completed in a tertiary academic medical center emergency room. All adult CPR events within the emergency department utilizing …


Frequency And Outcome Of Peg Tube Implantations In Hospitalized Parkinson's Disease Patients, Rachael M. Burke, Ruina He, Hikaru Kamo, Tejas R. Mehta, Anne Brooks, Adrianne Smiley, Michael S. Okun, Christopher W. Hess, Matthew A. Remz Aug 2026

Frequency And Outcome Of Peg Tube Implantations In Hospitalized Parkinson's Disease Patients, Rachael M. Burke, Ruina He, Hikaru Kamo, Tejas R. Mehta, Anne Brooks, Adrianne Smiley, Michael S. Okun, Christopher W. Hess, Matthew A. Remz

Department of Neurology Faculty Papers

BACKGROUND: Dysphagia is a known complication of Parkinson's Disease (PD). Percutaneous endoscopic gastrostomy (PEG) tube placement is a therapy for select patients with dysphagia. There is a paucity of information on the role of PEG in PD management.

OBJECTIVES: To investigate the frequency and outcomes of PEG tube implantations in hospitalized patients with PD.

METHODS: We performed a retrospective review of the PINC AI™ Healthcare Database of hospitalized PD patients between 2017 and 2023. PEG implantation, discharge status, and aspiration pneumonia (AP) diagnoses were collected and analyzed. The relationships between AP and PEG were evaluated using logistic regression. Generalized estimating …


A Case Report Of Myocardial Infarction Complicated With Blood Pressure Fluctuations Caused By Pheochromocytoma, Huiping Li, Wei Yang, Yu Feng, You Zhang, Gan-Xin Yan, Chuanyu Gao Aug 2026

A Case Report Of Myocardial Infarction Complicated With Blood Pressure Fluctuations Caused By Pheochromocytoma, Huiping Li, Wei Yang, Yu Feng, You Zhang, Gan-Xin Yan, Chuanyu Gao

Department of Medicine Faculty Papers

Pheochromocytoma typically presents with sustained or paroxysmal hypertension, but initial manifestation as acute non-ST-segment elevation myocardial infarction (NSTEMI) is rare. Peri-procedural hemodynamic fluctuations are often dramatic, making diagnosis and management challenging. We report a 51-year-old male admitted with chest tightness for 17 days. Elevated troponin and coronary angiography showing multivessel disease with total occlusion of the mid-left anterior descending artery (LAD) led to a preliminary diagnosis of NSTEMI. During percutaneous coronary intervention, blood pressure surged to 240/130 mmHg; intravenous nitroprusside caused an instantaneous drop to 95/55 mmHg, with rapid rebound to >200 mmHg upon withdrawal, showing no clear temporal relationship …


The Measured Toll: Visualizing The Hidden Impact Of Chronic Painkiller Use, Yun Chia (Lisa) Song Aug 2026

The Measured Toll: Visualizing The Hidden Impact Of Chronic Painkiller Use, Yun Chia (Lisa) Song

Theses

The Measured Toll: Visualizing the Hidden Impact of Chronic Painkiller Use investigates how clinical data can be reinterpreted through the lens of information design to reveal long-term effects on heart and liver health that are often overlooked or invisible. This project translates complex medical information into a visual language that prioritizes clarity, emotional resonance, and user engagement. Through a series of printed posters and a motion-based introduction, the work employs abstract design strategies—including subtle distortion, radial line structures, and restrained typography—to evoke a sense of internal tension and gradual change. By structuring the visuals to unfold as a narrative, the …


Retraction Notice: Are Your Kidneys Ok? Detect Early To Protect Kidney Health, Joseph A Vassalotti, Anna Francis, Augusto Cesar Soares Dos Santos Jr, Ricardo Correa-Rotter, Dina Abdellatif, Li-Li Hsiao, Stefanos Roumeliotis, Agnes Haris, Latha A Kumaraswami, Siu-Fai Lui, Alessandro Balducci, Vassilios Liakopoulos, World Kidney Day Joint Steering Committee Aug 2026

Retraction Notice: Are Your Kidneys Ok? Detect Early To Protect Kidney Health, Joseph A Vassalotti, Anna Francis, Augusto Cesar Soares Dos Santos Jr, Ricardo Correa-Rotter, Dina Abdellatif, Li-Li Hsiao, Stefanos Roumeliotis, Agnes Haris, Latha A Kumaraswami, Siu-Fai Lui, Alessandro Balducci, Vassilios Liakopoulos, World Kidney Day Joint Steering Committee

Asian Medical Journal and Alternative Medicine

No abstract provided.


E3 Ligase Rnf145 Regulates Airway Smooth Muscle Cell Proliferation Via The Pp2a-P70s6k Signaling Axis, Vijaya Kumar Gangipangi, Erin O. Curley, Deepak A. Deshpande, Pawan Sharma Aug 2026

E3 Ligase Rnf145 Regulates Airway Smooth Muscle Cell Proliferation Via The Pp2a-P70s6k Signaling Axis, Vijaya Kumar Gangipangi, Erin O. Curley, Deepak A. Deshpande, Pawan Sharma

Center for Translational Medicine Faculty Papers

Airway smooth muscle (ASM) is a key determinant of airway caliber and a major contributor to structural remodeling in obstructive lung diseases, including asthma and COPD. ASM proliferation is regulated by transcriptional and post-transcriptional mechanisms, including ubiquitin-dependent protein turnover mediated by E3 ubiquitin ligases. Here, we investigated the role of the RING-type E3 ligase RNF145 in mitogenic signaling and ASM cell proliferation. Human ASM cells were transfected with RNF145 shRNA or treated with the E3 ligase inhibitor SMER3, followed by stimulation with fetal bovine serum (FBS) or platelet-derived growth factor (PDGF). RNF145 knockdown or SMER3 treatment dose-dependently inhibited mitogen-induced ASM …


A Retrospective Study Of The Impact Of Standard Versus Staggered Arc Arrangements In Vmat Planning For Localized Prostate Cancer., Samantha J. Arthur Aug 2026

A Retrospective Study Of The Impact Of Standard Versus Staggered Arc Arrangements In Vmat Planning For Localized Prostate Cancer., Samantha J. Arthur

Masters Projects

Purpose: To evaluate whether implementing a staggered beam arrangement in volumetric modulated arc therapy (VMAT) improves treatment plan quality by enhancing normal tissue and organ-at-risk (OAR) sparing in patients with localized prostate cancer.

Methods: Ten patients meeting the study inclusion criteria were retrospectively replanned using both a standard arc technique and a staggered arc arrangement. Both plans were generated using identical optimization objectives and planning parameters. Dosimetric comparisons were performed after normalizing both plans to equivalent planning target volume (PTV) coverage. Dose-volume metrics were evaluated for the PTV, rectum, bladder, and penile bulb.

Results: The staggered beam arrangement produced statistically …


Self-Regulation For Early Childhood Classrooms, Emily Fox Aug 2026

Self-Regulation For Early Childhood Classrooms, Emily Fox

Masters Projects

The ability to self-regulate is essential for young children's social, emotional, behavioral, and academic development. However, growing exposure to adverse childhood experiences (ACEs), toxic stress, family instability, and other social and environmental stressors has contributed to challenges in the development of these skills. Children with underdeveloped self-regulation skills are more likely to experience difficulties with executive functioning, peer relationships, classroom behavior, and school readiness, demonstrating the need for early intervention. The purpose of this master's project was to investigate the major social and environmental stressors affecting young children's self-regulation and to develop a research-based intervention to support self-regulation development in …


Enhancing Mental Health Support For Motor Vehicle Accident (Mva) Survivors Through Occupational Therapy (Ot)-Led Support Groups, Emma K. Gooden Ms Aug 2026

Enhancing Mental Health Support For Motor Vehicle Accident (Mva) Survivors Through Occupational Therapy (Ot)-Led Support Groups, Emma K. Gooden Ms

Occupational Therapy Doctorate Capstone Posters

This doctoral capstone project, completed during a 14-week Applied Leadership Experience (ALE) with Georgetown-Scott County EMS (GSCEMS), focused on the ACOTE target areas of Program Development and Advocacy by creating an evidence-based, trauma-informed, occupational therapy support group curriculum for motor vehicle accident (MVA) survivors. A literature review and needs assessment identified a significant gap in post-crash care, as many survivors experience long-term psychological challenges—including PTSD, anxiety, depression, fear of driving, and disruptions in daily roles—despite care often emphasizing physical rehabilitation over emotional recovery. Drawing from observations of GSCEMS Peer Support and Critical Incident Stress Management meetings, current evidence, and ongoing …


Improving Response To Patient Alarms And Reducing Alarm Fatigue By Implementing An Alarm Fatigue Bundle Protocol In An Intermediate Care Unit At A Small Public Hospital, Christina Galvan Aug 2026

Improving Response To Patient Alarms And Reducing Alarm Fatigue By Implementing An Alarm Fatigue Bundle Protocol In An Intermediate Care Unit At A Small Public Hospital, Christina Galvan

Doctor of Nursing Practice Final Project Abstract

Purpose: This quality improvement (QI) project aimed to reduce alarm fatigue by implementing an alarm fatigue bundle protocol in an Intermediate Medical Unit (IMU) at a mall public hospital in Houston, Texas. The project aimed to achieve 80% compliance with daily electrode changes, improve alarm response times by 10%, reduce telemetry technician calls by 15%, and reduce alarm fatigue levels by 20%.

Background: Frequent non-actionable alarms can lead to desensitization, delayed responses, and missed alarms.

Methodology: The Plan-Do-Study-Act (PDSA) Model guided implementation of the CEASE bundle, focusing on staff education and daily electrode changes. Daily audits assessed skin preparation and …


Butte Priority Soils Operable Unit (Bpsou) 2026 Monthly Progress Report. Consent Decree For The Butte Priority Soils Operable Unit. Civil Action No. Cv 89-039-Bu-Seh, Josh Bryson Aug 2026

Butte Priority Soils Operable Unit (Bpsou) 2026 Monthly Progress Report. Consent Decree For The Butte Priority Soils Operable Unit. Civil Action No. Cv 89-039-Bu-Seh, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Strengthening Disease Surveillance In Malawi: Lessons From The 2022 Polio Outbreak, Zione N. Dembo, Mike Nenani Chisema, Joyce Beyamu, Tamandani Kapenga Nazimera Aug 2026

Strengthening Disease Surveillance In Malawi: Lessons From The 2022 Polio Outbreak, Zione N. Dembo, Mike Nenani Chisema, Joyce Beyamu, Tamandani Kapenga Nazimera

International Nursing Research Congress (INRC)

Background: Infectious disease outbreaks remain a persistent public health threat in Malawi. The 2022–2024 polio outbreak highlighted the central role of enhanced surveillance in timely detection and effective response. This abstract examines key strategies, outcomes, and lessons for strengthening surveillance and preparedness.

Methods: The response leveraged multiple surveillance approaches, including Acute Flaccid Paralysis (AFP) and environmental surveillance, improved specimen transport, digital tools for case investigation, and multiple supplementary immunization campaigns. Data from surveillance indicators and outbreak response activities were analyzed to assess performance and identify challenges.

Results: Enhanced surveillance proved effective, with rapid laboratory confirmation of the index case triggering …


Fieldwork Educators' Perspectives On Occupational Therapy Students Addressing Sexuality And Intimacy: Expectations, Supports, And Barriers, Elizabeth Deluca-Berg Aug 2026

Fieldwork Educators' Perspectives On Occupational Therapy Students Addressing Sexuality And Intimacy: Expectations, Supports, And Barriers, Elizabeth Deluca-Berg

Student Dissertations

Sexuality and intimacy are recognized as meaningful occupations within occupational therapy practice; however, they remain inconsistently addressed in clinical care. Previous research has identified limited educational preparation as a contributing factor to occupational therapists' discomfort and lack of confidence in addressing these occupations. Although classroom instruction provides foundational knowledge, Level II fieldwork serves as the primary setting in which students apply knowledge within authentic clinical environments. Despite the central role of FW educators in facilitating students' professional development, little research has explored how they prepare OT students to address sexuality and intimacy during fieldwork. The purpose of this basic qualitative …


Supporting Graduate Student Flourishing: Development Of A Whole-Person Formation Framework Through A University-Wide Task Force, Elisa Greene, Amanda Grieme-Bradley, Maren Bishop Aug 2026

Supporting Graduate Student Flourishing: Development Of A Whole-Person Formation Framework Through A University-Wide Task Force, Elisa Greene, Amanda Grieme-Bradley, Maren Bishop

Papers

How do whole persons form for lives of character and flourishing within graduate schooling years? What steps could an institution take to move toward that end? This work describes the process of one institution’s use of a task force examining these questions using a combination of literature review and structured interviews with key stakeholders across campus. The context of the institution’s unique mission, vision, and virtue framework provided a foundation out of which four areas of focus emerged: 1) infrastructure and representation, 2) belonging and community, 3) communication, and 4) professional identity formation. Investment in these institutional themes supports formation …


Comparing Boost Ptv/Plans Made On The Initial Prone Whole-Breast Ct Vs A Near-Boost Supine Re-Simulation Ct In Hypo-Fractionated Wbi Using A 3-Field Photon Boost Technique, Daniel Garcia Aug 2026

Comparing Boost Ptv/Plans Made On The Initial Prone Whole-Breast Ct Vs A Near-Boost Supine Re-Simulation Ct In Hypo-Fractionated Wbi Using A 3-Field Photon Boost Technique, Daniel Garcia

Masters Projects

Purpose: To evaluate dosimetric differences between breast boost plans generated on an initial prone whole-breast computed tomography (CT) simulation and those generated on a near-boost supine re-simulation CT acquired closer to boost delivery.

Methods: Ten patients receiving hypo-fractionated whole-breast irradiation followed by a sequential boost were retrospectively analyzed. Boost plans were generated using a three-field photon technique on both the initial prone CT and a near-boost supine CT. Target volumes, target coverage metrics, conformity index (CI), and organ-at-risk (OAR) doses were compared using paired statistical analyses.

Results: Mean clinical target volume and planning target volume were significantly smaller on the …


Intouch Week Of August 10, 2026, New York Medical College Aug 2026

A Distinct Form Of Fat Fibrosis Is Linked To Insulin Resistance In People With Hiv, Diana L Alba, Alaa Abdellatif, Moon Kyung Choi, Stephen M Brown Mayfield, Thuy An T Pham, David I Berrios, Antonio E Rodriguez, Marin Ewing, Tony R Figueroa, Judy Gonzalez-Vargas, Ningyan Zhang, Zhiqiang An, Dawei Bu, Steven G Deeks, Philipp E Scherer, Peter W Hunt, Suneil K Koliwad Aug 2026

A Distinct Form Of Fat Fibrosis Is Linked To Insulin Resistance In People With Hiv, Diana L Alba, Alaa Abdellatif, Moon Kyung Choi, Stephen M Brown Mayfield, Thuy An T Pham, David I Berrios, Antonio E Rodriguez, Marin Ewing, Tony R Figueroa, Judy Gonzalez-Vargas, Ningyan Zhang, Zhiqiang An, Dawei Bu, Steven G Deeks, Philipp E Scherer, Peter W Hunt, Suneil K Koliwad

The Brown Foundation: Institute of Molecular Medicine

BACKGROUND

Despite antiretroviral therapy (ART), people with HIV (PWH) are at heightened risk for insulin resistance (IR) and type 2 diabetes (T2D). Subcutaneous adipose tissue (SAT) fibrosis contributes to metabolic disease, but its role in IR among PWH is unknown. We investigated the relationship between SAT fibrosis and IR in PWH, along with transcriptional signatures to distinguish it from SAT fibrosis due to obesity.

METHODS

We analyzed body composition and SAT fibrosis (hydroxyproline) in 46 PWH and 74 people without HIV (PWoH), excluding individuals with T2D. We examined fibrosis-related gene transcription in the SAT using a targeted panel and measured …


Principles Of Endoscopic Resection For Early Esophageal Squamous Cell Carcinoma, Prasit Mahawongkajit Aug 2026

Principles Of Endoscopic Resection For Early Esophageal Squamous Cell Carcinoma, Prasit Mahawongkajit

Asian Medical Journal and Alternative Medicine

Esophageal squamous cell carcinoma (ESCC) remains a major global health burden, particularly in East and Southeast Asia, where incidence rates are highest. Early-stage ESCC represents a critical therapeutic window in which curative treatment can be achieved using minimally invasive, organ-preserving approaches. Advances in endoscopic imaging, including narrow-band imaging, magnifying endoscopy, chromoendoscopy, and emerging modalities such as endocytoscopy and artificial intelligence–assisted detection, have substantially improved the accuracy of early diagnosis and invasion depth assessment. According to current staging systems, including the AJCC/UICC classification, endoscopic resection is an established curative treatment for carefully selected patients with mucosal ESCC. Endoscopic submucosal dissection has …


The Employment Situation Of Veterans: July 2026, Institute For Veterans And Military Families At Syracuse University Aug 2026

The Employment Situation Of Veterans: July 2026, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

The July 2026 Employment Situation of Veterans report indicates that veteran unemployment increased slightly from 4.1% in June to 4.2% in July, while post-9/11 veteran unemployment improved marginally from 4.8% to 4.7%. Although overall veteran employment conditions remained relatively stable, notable differences emerged across demographic groups. Younger veterans (ages 18–24) experienced a significant decline in unemployment, while rates increased among veterans ages 45–54. Female veteran unemployment rose slightly but remained below that of nonveteran women. Sharp increases were reported among Black and Hispanic veterans, highlighting persistent disparities. Overall, the report reflects a generally resilient veteran labor market amid broader economic …


Breast Cancer Knowledge, Awareness And Screening Practices Among Female Healthcare Workers In Al-Mukalla, Yemen, Wafa Al Shoaeeb, Ahmed M. Badheeb, Faisal Ahmed, Amen Bawazir, Abdulla Bin Nabhan, Mohammed Badheeb, Abdulkader Bayazid Aug 2026

Breast Cancer Knowledge, Awareness And Screening Practices Among Female Healthcare Workers In Al-Mukalla, Yemen, Wafa Al Shoaeeb, Ahmed M. Badheeb, Faisal Ahmed, Amen Bawazir, Abdulla Bin Nabhan, Mohammed Badheeb, Abdulkader Bayazid

Sultan Qaboos University Medical Journal

Objectives: Breast cancer (BC) is the most common malignancy among women worldwide and represents a significant burden for Yemeni women. Early detection through breast self-examination (BSE) and knowledge of risk factors and symptoms are crucial. This study aimed to assess awareness, knowledge and practice regarding BC risk factors, symptoms and BSE among female healthcare workers (HCWs) in Al-Mukalla, Yemen. Methods: This cross-sectional study was conducted from September to October 2022 at three public hospitals in Al-Mukalla, Yemen. A census sampling approach was used to recruit HCWs. Data were collected using a validated self-administered questionnaire covering breast awareness practices, risk …


Malt1 Protease Inhibition Restrains Glioblastoma Progression By Reversing Tumor-Associated Macrophage-Dependent Immunosuppression In Mice, Juliana Hofstätter Azambuja, Saigopalakrishna Yerneni, Lisa Maurer, Hannah Crentsil, Gabriela Debom, Linda Klei, Mei Smyers, Chaim Sneiderman, Kristina Schwab, Rajesh Acharya, Aivi Nguyen, Josie Emery, John Little, Jeffrey Meridew, Yijen Lin Wu, Prasanna Ekambaram, Dong Hu, Pete Gough, John Bertin, Ari Melnick, Gary Kohanbash, Riyue Bao, Peter Lucas, Linda Mcallister-Lucas Aug 2026

Malt1 Protease Inhibition Restrains Glioblastoma Progression By Reversing Tumor-Associated Macrophage-Dependent Immunosuppression In Mice, Juliana Hofstätter Azambuja, Saigopalakrishna Yerneni, Lisa Maurer, Hannah Crentsil, Gabriela Debom, Linda Klei, Mei Smyers, Chaim Sneiderman, Kristina Schwab, Rajesh Acharya, Aivi Nguyen, Josie Emery, John Little, Jeffrey Meridew, Yijen Lin Wu, Prasanna Ekambaram, Dong Hu, Pete Gough, John Bertin, Ari Melnick, Gary Kohanbash, Riyue Bao, Peter Lucas, Linda Mcallister-Lucas

College of Life Sciences Faculty Papers

MALT1 protease is an intracellular signaling molecule that promotes tumor progression via cancer cell-intrinsic and cancer cell-extrinsic mechanisms. MALT1 has been mostly studied in lymphocytes, and little is known about its role in tumor-associated macrophages. We show that MALT1 is expressed in glioblastoma (GBM)-associated macrophages. Mechanistically, GBM tumor cells induce a MALT1-NF-κB signaling axis in macrophages, leading to enhanced macrophage migration and polarization toward an immunosuppressive ('M2-like') phenotype. Inactivation of MALT1 protease promotes transcriptional reprogramming that reduces migration and restores a macrophage anti-tumor 'M1-like' phenotype. Preclinical in vivo analysis shows that MALT1 inhibitor treatment results in immuno-reactivity of GBM-associated macrophages …


Sandbox Fictions, Douglas Sarro Aug 2026

Sandbox Fictions, Douglas Sarro

Osgoode Hall Law Journal

Regulatory sandboxes are designed to give firms space to offer novel products and services to consumers on a trial basis, under an interim, tailor-made regulatory regime. Ideally, this leaves regulators better placed to understand how rules ought to be modified to accommodate new, socially beneficial offerings on a more permanent basis. But little is known about sandboxes’ implications for consumers. Will they reduce barriers to entry for innovative offerings that do a better job of serving consumer needs? Or will they lead regulators to compromise on consumer protections, allowing low-quality or even fraudulent offerings to flow into the markets they …


Translational Reading Frame Predicts The Pathogenicity Of C-Terminal Frameshift Deletions In Mecp2, Jacky Guy, Elena Hein, Beatrice Alexander-Howden, Timur Von Bock Und Polach, Tricia Mathieson, Benjamin P Kleinstiver, Huda Y Zoghbi, Adrian Bird Aug 2026

Translational Reading Frame Predicts The Pathogenicity Of C-Terminal Frameshift Deletions In Mecp2, Jacky Guy, Elena Hein, Beatrice Alexander-Howden, Timur Von Bock Und Polach, Tricia Mathieson, Benjamin P Kleinstiver, Huda Y Zoghbi, Adrian Bird

Duncan NRI Faculty and Staff Publications

Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome. A cluster of frameshift-causing C-terminal deletions (CTDs) removes ~100 amino acids and accounts for approximately 10% of RTT-causing mutations. Their pathogenicity is unexpected because this C-terminal domain is dispensable in mice. Analysis of pathogenic and benign human MECP2 variants reveals that some individuals with apparently typical CTDs do not develop Rett syndrome, confirming that C-terminal truncations are not intrinsically pathogenic. Using human sequence data and mouse models we show that pathogenicity results from a marked reduction in MeCP2 levels and depends on the presence of a proline proline …


Understanding Brain Fog During Menopause, Cris Meier, Moth Huenemann, Ashley Yaugher, Cara Murray Aug 2026

Understanding Brain Fog During Menopause, Cris Meier, Moth Huenemann, Ashley Yaugher, Cara Murray

All Current Publications

Brain fog is an inability to concentrate or think clearly and is a common symptom of perimenopause and early in the menopause phase. While not everyone who goes through menopause will have brain fog, it is a common symptom, and it can be helpful to understand why brain fog occurs. This fact sheet provides helpful information to understand brain fog and ideas you can use to manage it.


Cigarette Smoke Induces Fasn-Dependent Fatty Acid Metabolic Rewiring To Drive Bladder Cancer Progression, Chandra Sekhar Amara, Danthasinghe Waduge Badrajee Piyarathna, Abu Hena Mostafa Kamal, Yuen San Chan, Karthik Reddy Kami Reddy, Chandra Shekar R Ambati, Mohammed Khurshidul Hassan, Pratik Shriwas, Tanmay Gandhi, Antrix Jain, Tanja Gangnus, Pooja Popli, Roshan Borkar, Sung Wook Kang, Silvia L Summers, Vasanta Putluri, Sandra L Grimm, Sharan Venkatesh, Ningxin Song, Erin H Seeley, Jenna Hedlich-Dwyer, Shu-Hsia Chen, Nupam P Mahajan, Abhinav K Jain, Lacey Elizabeth Dobrolecki, Gabrielle A Wells, Hugo Villanueva, Jenny Li, Xuefeng Liu, Roni J Bollag, Anna Malovannaya, Sung Yun Jung, Hyun-Sung Lee, Irfan A Asangani, Martha K Terris, Chad J Creighton, Leomar Y Ballester, Balasubramanyam Karanam, Suyu Liu, Minjae Lee, Rajeeva R Raju, M Minhaj Siddiqui, Livia S Eberlin, Ramakrishna Kommagani, Arun Sreekumar, Jianjun Gao, Nicolas L Young, H Courtney Hodges, Cristian Coarfa, Natalie R Gassman, Seth P Lerner, Yair Lotan, Nagireddy Putluri Aug 2026

Cigarette Smoke Induces Fasn-Dependent Fatty Acid Metabolic Rewiring To Drive Bladder Cancer Progression, Chandra Sekhar Amara, Danthasinghe Waduge Badrajee Piyarathna, Abu Hena Mostafa Kamal, Yuen San Chan, Karthik Reddy Kami Reddy, Chandra Shekar R Ambati, Mohammed Khurshidul Hassan, Pratik Shriwas, Tanmay Gandhi, Antrix Jain, Tanja Gangnus, Pooja Popli, Roshan Borkar, Sung Wook Kang, Silvia L Summers, Vasanta Putluri, Sandra L Grimm, Sharan Venkatesh, Ningxin Song, Erin H Seeley, Jenna Hedlich-Dwyer, Shu-Hsia Chen, Nupam P Mahajan, Abhinav K Jain, Lacey Elizabeth Dobrolecki, Gabrielle A Wells, Hugo Villanueva, Jenny Li, Xuefeng Liu, Roni J Bollag, Anna Malovannaya, Sung Yun Jung, Hyun-Sung Lee, Irfan A Asangani, Martha K Terris, Chad J Creighton, Leomar Y Ballester, Balasubramanyam Karanam, Suyu Liu, Minjae Lee, Rajeeva R Raju, M Minhaj Siddiqui, Livia S Eberlin, Ramakrishna Kommagani, Arun Sreekumar, Jianjun Gao, Nicolas L Young, H Courtney Hodges, Cristian Coarfa, Natalie R Gassman, Seth P Lerner, Yair Lotan, Nagireddy Putluri

Faculty, Staff and Students Publications

Cigarette smoke promotes bladder tumor growth by enhancing cancer cell survival and proliferation through smoke mediated carcinogens. FASN, a key enzyme in fatty acid synthesis, is dysregulated in many cancers and correlates with aggressive phenotypes. In this study, we demonstrate elevated fatty acid levels and FASN specifically in smokers with bladder cancer. Elevated FASN under smoke exposure imparted epigenetic alterations, particularly histone acetylation, impacts DNA repair and DNA-binding transcription factors which regulate metabolic pathways. Under cigarette smoke, bladder cancer cells undergo a metabolic shift, utilizing glutamine as a major carbon source through reductive carboxylation to fuel fatty acid biosynthesis via …


Cross-Reactivity Of 15 Jev Antigen-Directed Rabbit Antisera With Three Clinically Important Jev Serogroup Members: Wnv, Mvev, And Slev, Sang-Im Yun, Young-Min Lee Aug 2026

Cross-Reactivity Of 15 Jev Antigen-Directed Rabbit Antisera With Three Clinically Important Jev Serogroup Members: Wnv, Mvev, And Slev, Sang-Im Yun, Young-Min Lee

Animal, Dairy, and Veterinary Science Faculty Publications

Japanese encephalitis virus (JEV), the prototype member of the JEV serogroup within the genus Orthoflavivirus (family Flaviviridae), is closely related to West Nile virus (WNV), Murray Valley encephalitis virus (MVEV), and St. Louis encephalitis virus (SLEV). To characterize antigenic cross-reactivity within this group, we evaluated 15 region-specific rabbit antisera, previously generated against nearly the entire JEV protein-coding region, by immunoblotting whole-cell lysates from BHK-21 cells infected with WNV, MVEV, or SLEV, with JEV included as a reference. Six antisera (α-EN-term, α-NS2B, α-NS3N-term, α-NS3C-term, α-NS5N-term, and α-NS5C-term) robustly recognized homologous …


Understanding The Long-Term Patterns Of Change Of A Tidal Marsh In Mission Bay, San Diego, California, Carrie A. Shuster, Theresa Sinicrope Talley Ph.D., Drew Talley Ph.D., Zhi-Yong Yin Ph.D., Kellie Uyeda Ph.D. Aug 2026

Understanding The Long-Term Patterns Of Change Of A Tidal Marsh In Mission Bay, San Diego, California, Carrie A. Shuster, Theresa Sinicrope Talley Ph.D., Drew Talley Ph.D., Zhi-Yong Yin Ph.D., Kellie Uyeda Ph.D.

Theses

Coastal marshes are among California’s most productive ecosystems and the most impacted, having been extensively modified by dredging, filling, and urban development. This thesis investigates over a century of change for a marsh in Northern Mission Bay, San Diego, California using ecological and spatial analyses.

Chapter 1 provides an overview of the environmental history and current land use of the Northern Mission Bay marsh, tracing changes from pre-contact Indigenous stewardship through colonial and modern urban development. It also introduces a restoration plant palette derived from historical and contemporary species occurrences, ecological functions, and documented cultural uses. By integrating ethnobotanical knowledge …


Potential Effects Of Sugar-Sweetened Beverage Taxation On Oral And Systemic Health Outcomes, Rahnuma Ahmad, Muhammad Noorani, Mainul Haque, Mohammed Razzaque Aug 2026

Potential Effects Of Sugar-Sweetened Beverage Taxation On Oral And Systemic Health Outcomes, Rahnuma Ahmad, Muhammad Noorani, Mainul Haque, Mohammed Razzaque

School of Medicine Publications

No abstract provided.