Digital Commons Network^™

From Constraint To Freedom, George Rodriguez

Fresh Voices: Composition at Cal Poly

No abstract provided.

On Going Long Term And Avoiding The Thanksgiving Turkey Drop, Liana Meffert

Fresh Voices: Composition at Cal Poly

No abstract provided.

Writing With Images, Brenda Helmbrecht

Fresh Voices: Composition at Cal Poly

No abstract provided.

Slo Streets: Analysis, David Maxson

Fresh Voices: Composition at Cal Poly

No abstract provided.

Genesis And Structure Of Hegel's Phenomenology Of Spirit, Jean Hyppolite

Hannah Arendt Marginalia - All

No abstract provided.

Government Censorship In Comedy, Campbell E. Gavin

The Dialogue

This paper examines the role of public administration in shaping and restricting comedic expression in the United States, specifically focusing on the FCC’s regulation of broadcast media, targeting stand-up comedians and late-night show hosts. By applying Weber's and Wilson's theories of bureaucracy the paper analyzes how administrative power influences the boundaries of acceptable speech, through legal frameworks and discourse theory. An important court case involving governmental regulation of comedic speech was the FCC v. Pacifica Foundation. This case sets the stage for administrative power to grow in terms of limiting freedom of speech and paving the way for new administrations, …

The Effects Of Short-Term Individual Development Account For Young Workers In South Korea, Intae Yoon, Dong-Ho Jang

Journal of Social Work in the Global Community

This study evaluated a short-term individual development account for young workers (SIDAY) with low income in Gwangju Metropolitan City, South Korea. SIDAY used random sampling methods to form an experimental group (n = 191) and a control group (n = 106) out of 2,589 applications. The experimental group received a 100,000 Korean Won (KRW), which is the equivalent to an $85 USD monthly savings match for 10 months, as well as financial capability programs and services, such as online financial mentoring, spending plan consultations, and electronic financial newsletters. Upon completion of SIDAY, the experimental group on average had …

Adjunctive Probiotic Use During Antibiotic Exposure In Very Preterm Infants: A Narrative And Translational Review, Mustafa Törehan Aslan, Mustafa Altındiş, Fahri Ovalı

Journal of Pediatric Infectious Diseases

Infants born before 32 weeks of gestation are highly susceptible to late-onset sepsis because of immune immaturity, impaired intestinal barrier function, and frequent broad-spectrum antibiotic exposure. Whether probiotics should be continued or initiated during antibiotic therapy remains unresolved and is often conflated with routine prophylaxis in stable infants. This SANRA-guided structured narrative and translational review synthesized clinical, microbiome, resistome, mechanistic, and safety evidence identified in PubMed/MEDLINE, Scopus, and Web of Science through July 1, 2026, across three contexts: stable antibiotic overlap, suspected sepsis, and confirmed or unstable sepsis. Pooled prophylactic analyses suggest a small, heterogeneous reduction in late-onset infection (risk …

Paradoxical Reaction Presenting As Sacroiliitis In Brucellosis: A Case Report And Literature Review, Azer Karaman, Sümeyye Bayram, Hatice Gaber Kurt

Journal of Pediatric Infectious Diseases

Although brucellosis is one of the most common zoonotic infections worldwide, the development of a paradoxical reaction during treatment hasrarely been reported in the literature. We present a 17-year-old patient who developed acute sacroiliitis in the second week of treatment for olecranon bursitis brucellosis, despite her initial clinical findings showing signs of improvement. After excluding other potential etiologies for sacroiliitis, clinical and radiological recovery was achieved by adding anti-inflammatory therapy without modifying the existing antimicrobial regimen. Consequently, the clinical picture was evaluated as a paradoxical reaction. This case emphasizes that new symptoms or clinical worsening during brucellosis treatment should not …

Analysis Of Risk Factors And A Predictive Model For Recurrent Febrile Seizures Within A Single Febrile Illness In Children, Zheng Ge, Pao Yu, Kun Chen, Bi Zhou

Journal of Pediatric Infectious Diseases

Objective: To investigate predictive factors for seizure recurrence in children with febrile seizures (FS) within a single febrile illness, providing a basis for early clinical identification and preventive measures. Methods: We conducted a retrospective analysis of children with FS admitted to the Department of Pediatrics, Suzhou Hospital Affiliated to Anhui Medical University, from April 2023 to December 2025. A total of 337 children met the inclusion criteria. Children with more than one seizure within the same febrile ilness were classified as the recurrent febrile seizures (RFS) group, and those with a single seizure as the non-recurrent febrile seizures (NRFS) group. …

Beyond Pneumonia: Nonspecific And Extrapulmonary Manifestations Of Mycoplasma Pneumoniae Infection In Children, Svjetlana Mikulić

Journal of Pediatric Infectious Diseases

Mycoplasma pneumoniae is a well-recognized cause of respiratory infection in children, but its clinical spectrum extends beyond the lungs. Extrapulmonary manifestations may occasionally precede respiratory symptoms or dominate the presentation, making the diagnosis more difficult. This narrative clinical review focuses on nonspecific and extrapulmonary manifestations reported in pediatric patients, including neurological, mucocutaneous, hematological, cardiovascular, hepatic, gastrointestinal, and musculoskeletal complications. Relevant literature published between 2000 and 2026 was reviewed using PubMed/MEDLINE, Scopus, and Google Scholar. Most reported extrapulmonary manifestations appear to be immune-mediated, although direct microbial effects and vascular or prothrombotic mechanisms may contribute in selected cases. Clinical presentations range from …

Divergent Outcomes In Two Pediatric Cases Of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis, Zhang Kai-Jing, Li Ran, You Deng-Xia, Li Yinjie, Qin Tian-Tian, Liang Xiao-Jing, Huang Jing

Journal of Pediatric Infectious Diseases

This study retrospectively analyzed the clinical data of two 19-month-old children diagnosed with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) who received treatment with a dexamethasone combined with etoposide (VP-16) regimen. Both children met the early remission criteria for body temperature, IL-10, and IFN-γ within 48-72 hours after treatment initiation, but their clinical outcomes were markedly different. In Case 1, the EBV-DNA load decreased significantly during the initial treatment phase, and platelet counts steadily increased after treatment; the patient had a favorable prognosis at the 2-year follow-up. In Case 2, the EBV-DNA load did not decrease but instead increased during the initial …

Age-Dependent Variations In Clinical Presentation, Laboratory Parameters, And Coronary Outcomes In Kawasaki Disease: A 10-Year Retrospective Cohort Study Of 480 Pediatric Patients In Eastern China, Zhuying Zhou, Chen Wang, Aole Li, Saeed Saboor, Xiaoli Li, Xiaowei Li, Xianmei Huang, Chunming Jiang

Journal of Pediatric Infectious Diseases

Objective: This study investigated the age-dependent clinical characteristics of Kawasaki disease (KD) in pediatric patients and assessed the influence of age on disease presentation and outcomes. Methods: A retrospective analysis was conducted of 480 children diagnosed with KD who were admitted to Hangzhou First People's Hospital between 2013 and 2022. Subjects were stratified into two cohorts based on age: <2 years and 2-14 years). Demographic data, clinical manifestations, laboratory parameters, comorbidities, and coronary artery abnormalities were comprehensively evaluated across the age groups. Results: Time from symptom onset to diagnosis was significantly prolonged in the older cohort (z=-2.70, P=0.007). The incidence of cervical lymphadenopathy was markedly higher in older children (χ²=15.12, P<0.001), while peripheral extremity changes were significantly less frequent (χ²=5.79, P=0.016). The younger cohort exhibited significantly elevated platelet counts, alanine aminotransferase, and NT-proBNP levels compared to older patients (z=-3.57, P<0.001; z=-2.39, P=0.02; z=-3.59, P<0.001, respectively). Coronary artery dilatation and aneurysm formation occurred more frequently in younger patients (z=7.70, P=0.006; z=14.63, P<0.001). However, coronary artery recovery rates following intravenous immunoglobulin therapy showed no significant inter-group differences (P>0.05). Conclusions: The clinical presentation of KD demonstrates significant age-dependent variation. Clinicians should maintain a high index of suspicion for KD in older children presenting with fever and cervical lymphadenopathy. In younger patients with KD, close monitoring of hepatic function, platelet …

A Case Of Hemophagocytic Lymphohistiocytosis Caused By Human Herpesvirus 6b, Lihong Gao, Yang Wen

Journal of Pediatric Infectious Diseases

Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory response syndrome. Common infectious triggers include Epstein Barr virus, cytomegalovirus, bacteria, and other pathogens. We report a case of HLH caused by human herpesvirus-6 (HHV-6) in a pediatric patient. Based on the HLH-2004 diagnostic criteria, the patient fulfilled 5 of 8 criteria, establishing a definitive diagnosis. HHV-6-associated HLH is rarely reported in the literature. The etiological diagnosis was confirmed through metagenomic next - generation sequencing, highlighting its utility in identifying underlying causes of HLH when the etiology remains unknown.

Advancing A Familial Understanding Of International Students, Prof-Collins Ifeonu Dr

Critical Internationalization Studies Review

No abstract provided.

The Impact Of Temporary Housing Policies On Social Stability: A Case Study Of The Informal Settlements Development Project In Jeddah, Mansour Alshehri, Waleed Alzamil

UB Journal for Humanities

This study examines the impact of temporary housing policies on social stability in the context of slum redevelopment in Jeddah, focusing on the effectiveness of transitional housing mechanisms in mitigating displacement impacts. It adopts a descriptive-analytical approach within a qualitative case study, drawing on theoretical frameworks, international standards, expert interviews, and analysis of official documents. The findings show that housing security was organizationally achieved through rental support, but remained limited due to its temporary nature and unclear continuity. They also reveal weakened social ties caused by the absence of policies preserving community networks, along with challenges in accessing services despite …

The Narrations Of Ḥumayd Ibn ʿAbd Al-Raḥmān Criticized Due To Differences In Their Transmission In ʿIlal Al-Dāraqutnī: A Compilation And Study, Nadiya Bint ʿAbd Al-Raḥmān Ibn ʿAbd Allāh Al-ʿAsbalī Al-Shahrī

UB Journal for Humanities

The study focuses on collecting and examining the narrations of Ḥumayd ibn ʿAbd al-Raḥmān al-Ḥumayrī that were identified as defective due to discrepancies in their transmission, as recorded in al-Dāraquṭnī’s al-ʿIlal. One of the reasons for selecting this topic is that the researcher did not find any previous study devoted specifically to this subject. The significance of the study stems from the importance of the science of ʿIlal (hidden defects in ḥadīth) and, in particular, from the significance of al-Dāraquṭnī’s al-ʿIlal. The study aims to provide a biographical account of Ḥumayd ibn ʿAbd al- Raḥmān, collect and examine his defective …

From Readiness To Transformation: The Mediating Role Of Digital Maturity In Linking Ai Readiness To Organizational Change In Hospitals, Muhammad Ryan Adi Putra, Giovanni Reynaldo, Dewi Sri Surya Wuisan

Journal of Health Research

Background: Organizational readiness is essential for AI-enabled digital transformation as healthcare organizations increasingly integrate artificial intelligence (AI). However, empirical evidence regarding the relationship between AI readiness and organizational change, the mediating role of digital maturity, remains limited in healthcare settings. This study investigated the mediating role of digital maturity in the relationship between AI readiness and organizational change.

Methods: This cross-sectional study involved 300 healthcare professionals from two Indonesian hospitals: Persahabatan Hospital (n = 165) and St. Carolus Hospital (n = 135). Data were collected using a questionnaire and analyzed through Partial Least Squares Structural Equation Modeling (PLS-SEM) to assess …

Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li

Journal of Food and Drug Analysis

Purpose: Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Methods: Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for PCOS from the FinnGen R12 database. These targets were integrated with the active ingredients and protein targets of HTHXD retrieved from the TCMSP and BATMAN-TCM databases for network pharmacology analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted. Core targets were validated using molecular docking. Experimental validation was performed using a letrozole-induced …

Impact Of The Widespread Use Of Online Pharmacies On Overall Consumer Safety, Hasanain Am. Abbas, Eswar Kumar Kilari, Shereen M. Mekkey, Hussein Ahmed Jabbar, Mohammed Haider Majid, Haider Majeed Abd Abbas, Hassanein Khaled Hassan

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Online pharmacies improve access to medicines by offering convenient ordering and home delivery, but their growth also creates important risks for medication safety and public health. This review examines the benefits and hazards associated with online medicine supply, including access without a valid prescription, falsified and substandard products, inappropriate medicine use, privacy breaches, and weak cross-border regulatory oversight. The available evidence indicates that illicit online sellers can expose consumers to products of uncertain identity, quality, and dose, while vulnerable users may have limited ability to distinguish legitimate services from unlawful vendors. At the same time, licensed platforms can support continuity …

Preparation And In Vitro Evaluation Of Gastro-Retentive Tablets Of Frusemide Using Gas Generating Excipients As Floating Mechanism, Yousif K. Younis, Ahmed Yousif Fadhel, Nihad Hussein Ahmed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Frusemide is a loop diuretic used for hypertension, heart failure among many other indications. It has an absorption window in the stomach and it's a class IV drug according to BCS with low bioavailability.
Floating tablets are one of the dosage forms that is best suited for drugs with such absorption window and gas generating excipients can be used to reduce floating lag times even more than traditional floating tablets that relay on density difference alone.
The aim of the study was to investigate the feasibility of floating tablets as a convenient dosage form for oral administration of frusemide aiming …

Impact Of Erythropoietin Therapy On Inflammatory Biomarkers In Chronic Kidney Disease: A Comparative Study, Riyam Naji Al_Alwani, Jahanbakhsh Asadi, Zainab Mohammadi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Chronic kidney disease (CKD) is a progressive disorder frequently complicated by anemia and a persistent inflammatory state, both of which significantly contribute to morbidity and mortality. Reduced renal production of erythropoietin (EPO) is the primary cause of anemia in CKD. Emerging evidence suggests that EPO may exert anti-inflammatory and metabolic effects beyond its hematopoietic role. This study aimed to compare serum EPO levels and inflammatory biomarkers in CKD patients treated with EPO versus untreated CKD controls.
Material and Methods: This cross-sectional analytical study was conducted on 60 adult patients with CKD undergoing regular hemodialysis. Participants were divided into two …

Current Advances In Cancer Immunotherapy: Mechanisms, Therapeutic Strategies, Challenges, And Future Perspectives, Mohamed E. Abd El-Hack, Mahmoud Moustafa, Mahmoud Kamal, Vincenzo Tufarelli, Muhammad Arif, Laith Aldabbagh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Cancer immunotherapy has emerged as a transformative therapeutic strategy that harnesses the host immune system to recognize and eliminate malignant cells. This review provides a comprehensive overview of current immunotherapeutic approaches, including immune checkpoint inhibitors (ICIs), monoclonal antibodies (mAbs), cancer vaccines, dendritic cell (DC)-based vaccines, chimeric antigen receptor (CAR)-T cell therapy, and oncolytic virus therapy. The mechanisms of action, therapeutic applications, and clinical benefits of each modality are discussed. Monoclonal antibodies selectively target tumor-associated antigens, whereas ICIs restore antitumor immunity by blocking inhibitory immune checkpoints. Cancer vaccines and DC-based vaccines enhance antigen-specific immune responses, while CAR-T cell therapy employs genetically …

Computational Design, Molecular Docking, Sar, And Admet Analysis Of Novel Jak1 Inhibitors As A Possible Treatment For Rheumatoid Arthritis, Sarah Ahmed Waheed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Rheumatoid arthritis is an inflammatory autoimmune disease affecting the joints which eventually leads to systemic comorbidities. Its pathogenesis was attributed to disturbances in the Janus Kinase/Signal Transducer and Activator of Transcription signaling pathway. In this research, an innovative lead compound C6 was created and docked toward Janus Kinase1 (JAK1). The docking process was confirmed by re-docking of the co-crystallized ligand MI1 (Tofacitinib). C6 showed a predicted docking score of -9.17 kcal/mol, with enhancement of 1.26 kcal/mol over Tofacitinib. Evaluation of the interactions showed a framework of five hydrogen bonds within the binding site involving an important contact with Glu966 as …

Diagnostic Accuracy Of Quantitative Coronary Analysis As Compared With Instantaneous Wave-Free Ratio In Intermediate Coronary Lesions: A Prospective Vessel-Level Study, Tamer Mosaad Ragab, Khaled Ahmed Alkhashab, Mohamed Zaki Hussain, Ibrahim Mohammed Nosseir, Marwa Salah Sayed, Waleed Khaled Ali Salem

Journal of the Saudi Heart Association

Background: Instantaneous wave-free ratio (IFR) represents a new vasodilator-free innovative approach which is considered as a gold standard for functional assessment of the hemodynamic significance of intermediate coronary stenoses. Although relatively safe, iFR is still an invasive procedure that has its potential hazards, complications and cost. Two-dimensional quantitative coronary analysis (2D-QCA) is a non-invasive technique that has emerged robustly as an excellent and attractive tool for delineating coronary anatomy.

Aims: To assess the ability of two-dimensional quantitative coronary analysis (2D-QCA) to guide decision-making for quantification of severity of intermediate coronary stenoses (40–80% diameter stenosis) in each of the three main …

Cvgtc‑3.1: A Unified, Place‑And‑Route‑Independent Power‑Grid Research Engine For Early Voltage‑Drop, Dynamic Droop, Electromigration, And Thermal‑Coupled Analysis, Michael Victor Caldwell Mr.

Defensive Publications Series

This disclosure describes CVGTC‑3.1, a fully buildable and testable open‑hardware research engine for early power‑grid analysis in system‑on‑chip (SoC) design. The system integrates:

• A place‑and‑route‑independent DC IR‑drop solver

• A dynamic RLC droop simulator

• An electromigration lifetime estimator

• A machine‑learning IR‑prediction model

• A physical PDN coupon for hardware validation

• A multi‑domain thermal stack including:

• Arachne Microfluidic Interposer (microfluidic cooling + CTE control)

• Vortex‑TPMS Core (high‑flux thermal removal)

• Forgecell PCM Module (transient heat buffering)

• CRFG Thermoacoustic Pump (thermal stabilization)

• MMRA Resonant Diagnostics (EM/IR hotspot detection)

• APR‑AI telemetry for automated calibration and control

• Mechanic’s Battery for stable DC supply during testing

The solver …

Octvec-Xd: Deterministic Multi-Resolution Integer Signatures For Multidimensional Vectors, Nenad Micic

Defensive Publications Series

A technique is proposed herein for converting a multivariate integer vector into a deterministic, fixed-size, multi-resolution signature that separates sign pattern, magnitude scale, quantization frame, and coarse-to-fine direction. Exact integer quantization, bounded portable arithmetic, nested resolution fields, and versioned records provide reproducible results across heterogeneous platforms without floating-point arithmetic, training, dynamic allocation, or per-stream model state. Under a common pinned frame and the declared lossless coarse capacity, participating devices or streams can be correlated by exact tuple equality, while a graded comparison ladder supports finer similarity evaluation. The technique explicitly identifies capacity limits, collision regimes, frame-compatibility requirements, reverse quantization bounds, …

Caldwell Chip‑Scale Vortex‑Tpms Thermal Engine (Ccvte‑3.X) Open‑Hardware • No Patents • No Secrets • Builder‑Ready, Michael Victor Caldwell Mr.

Defensive Publications Series

CCVTE‑3.x is an upgraded chip‑scale thermal engine integrating micro‑vortex conditioning, Diamond/I‑WP TPMS hotspot suppression, graded Diamond→Gyroid transitions, micro‑restrictor flow balancing, and micro‑bypass hydraulic stabilization. It is designed for direct‑die cooling, chiplet cooling, microfluidics, and semiconductor hotspot management.

This invention incorporates improvements derived from prior Caldwell inventions including UGCRM‑2.0, Mechanic’s Battery v3.0, GCI #259‑B, Arachne v9.0, and CVGTC‑2.x. All geometry is scaled to chip‑level dimensions and is fully manufacturable using CNC micromachining, micro‑EDM, or SLM metal printing.

CCVTE‑3.x provides measurable improvements in hotspot suppression, thermal resistance, pump efficiency, boundary‑layer disruption, and transient thermal stability.

Caldwell Variable‑Topology Vortex‑Gyroid Thermal‑Hydraulic Core (Cvgtc‑2.X) Unified Tdcommons Posting + Integration Map + Fabrication Blueprint + Test‑Bench Layout Open‑Hardware • No Patents • No Secrets • Fully Engineer‑Ready, Michael Victor Caldwell Mr.

Defensive Publications Series

CVGTC‑2.x is a next‑generation open‑hardware cold‑plate architecture designed for high‑power electronics, AI accelerators, HPC processors, and advanced thermal research. It integrates:

• heat‑flux‑matched flow allocation

• impedance‑matched manifolds

• variable‑topology TPMS zones

• graded Diamond→Gyroid transitions

• vortex boundary‑layer conditioning

• bypass‑protected hydraulic architecture

• Arachne v9.0 structural + sensing envelope

• optional CRFG‑2.0 transient gradient injection

• optional downstream TEG energy recovery

This document provides:

• TDCommons‑ready disclosure

• Integration map of all six upgraded inventions

• Full fabrication blueprint with hard dimensions and tolerances

• Complete test‑bench wiring + sensor layout

Everything required to build and validate CVGTC‑2.x is included.

Theta-Xd: Integer-Only Direction Change And Slow-Drift Detection In Multivariate Telemetry Streams, Nenad Micic

Defensive Publications Series

A system is proposed herein for detecting sudden turns, changes in turning behavior, and slow drift in the joint movement of multivariate telemetry counters. The system uses an overflow-bounded integer direction metric and an exact division-free threshold gate, requires work linear in the number of counters and fixed-size per-stream state, and produces exactly reproducible results without floating-point arithmetic or model training. Optional discrete direction keys support compact grouping, and peer-relative integer classification identifies outliers among comparable elements. The resulting signals can be generated close to the telemetry source, where independent per-counter thresholds may miss coordinated changes.