Digital Commons Network^™

Local Adaptation To Host Plants In Herbivorous Insects: A Meta-Analysis, Mariana Abarca, Shannon M. Murphy, Gina M. Wimp, Mattheau S. Comerford, Chase Ryan-Embry, Dhaval K. Vyas, Macawan S. Luu, Mayra C. Vidal

Biological Sciences: Faculty Publications

Local adaptation, wherein populations are well-adapted to local biotic and abiotic conditions, is a common outcome of natural selection and a driver of diversification.Previous theory identified two criteria to detect local adaptation: (a) the home-away criterion compares the fitness of a population in its home environment to its fitness in a different environment and (b) the local-foreign criterion examines differences in fitness between a local and a foreign population when experiencing the local environment.We conducted a meta-analysis synthesizing empirical evidence of insect herbivores' local adaptation to their host plants using both criteria to assess how diet breadth, geographic distance among …

Lidocaine Combined With Low-Dose Esketamine For Movement-Evoked Pain After Hepatectomy: A Double-Blind Randomised Controlled Trial, Jingwen Wu, Jialu Wan, Yi Kang, Lajing Luowu, Mengmeng Zhou, Lulong Bo, Daniel I Sessler, Chunling Jiang

Faculty, Staff and Student Publications

Introduction: Pain following hepatectomy may delay recovery and increase opioid use. We tested the primary hypothesis that combining lidocaine and low-dose esketamine would reduce movement-evoked pain 24 h after hepatic resection. We also evaluated whether this approach reduced opioid consumption and improved quality of recovery.

Methods: Patients having elective hepatic resections were allocated randomly to receive lidocaine-esketamine or placebo from induction of anaesthesia until the end of surgery. After surgery, patients allocated to lidocaine-esketamine were given a continuous infusion of lidocaine with esketamine for 72 h. All patients received transversus abdominis plane blocks with ropivacaine 2 mg.kg-1 after induction of …

Hydroxyethyl Starch And Perioperative Complications: A Systematic Review And Meta-Analysis, E Wang

Faculty, Staff and Student Publications

Background: Based on renal injury reported in critically ill and septic patients, the U.S. Food and Drug Administration issued a black box warning regarding hydroxyethyl starch (HES 130/0.4) use in 2013 and expanded the warning to surgical and trauma patients in 2021. Similarly, the European Medicines Agency initiated withdrawal of hydroxyethyl starch in 2022. This study was a new meta-analysis focused on renal injury designed to complement a 2021 meta-analysis of perioperative hydroxyethyl starch use, adding 45 trials and 6,895 patients. The focus was acute kidney injury and preoperative-to-postoperative change in creatinine concentration in surgical patients.

Methods: This study searched …

Diagnostic Delay In Acute Care Settings And The Economic Burden Of Pemphigus And Pemphigoid: A Literature Review, Sana Altaf, Sara Shah, Simran Gill, Sarah Mazurovsky, Yasmeen Magharehabed, Carolyn Duong, Karen Vo

Student Publications

Pemphigus vulgaris (PV), bullous pemphigoid, and paraneoplastic pemphigus are autoimmune blistering diseases carrying significant mortality risk and economic burden. Diagnosis is frequently delayed in acute care settings, where these conditions mimic common dermatoses such as cellulitis, aphthous stomatitis, and Stevens-Johnson syndrome/toxic epidermal necrolysis. While emergency departments appropriately triage and admit severely affected patients, definitive diagnosis is often delayed across the acute care continuum, averaging 6 to 12 months from symptom onset. These delays result in repeated visits, inappropriate therapies, and avoidable hospitalizations. Pemphigus vulgaris hospitalization costs average $14,500 per patient annually in the United States, and cellulitis misdiagnosis alone generates …

Prevalence And Availability Of Specialty Dental Care Sites For Children Covered By Medicaid And Chip In The United States, Jonmichael Cope, Aaron David, Chase Otto, Inder Sehgal

Student Publications

Introduction: Access to dental care is a critical aspect of children's healthcare. For these reasons, Medicaid and Children's Health Insurance Program (CHIP), administered by states, cover medically necessary services. Specialty providers can enroll and participate in state or state-contracted plans, but availability varies widely. Our research objective was to evaluate the availability of non-general dentist specialists in endodontics, oral and maxillofacial surgery, orthodontics/dentofacial orthopedics on the InsureKidsNow website for Medicaid/CHIP enrollees, on a state-by-state basis, and to compare these with pediatric dental availability.

Methods: This is an observational, cross-sectional descriptive study. InsureKidsNow.gov was searched to identify and compare available and …

Inaccurate Interpretation Of Hypoxia Signatures From Transcriptomic Analyses In Neuro-Oncology, Marco Gallo

Faculty, Staff and Students Publications

We aim to highlight problems with the biological interpretation of computationally-derived hypoxia signatures for neuro-oncology research. By reviewing important experimental work in the field, we discuss common misinterpretations of the concepts of normoxia and hypoxia. In fact, the concentration of oxygen in the adult brain is in the range of 1-7%. Unfortunately, this oxygen concentration range is often mistakenly considered hypoxic in neuro-oncology experiments, although it should be considered physioxic. Further, given the lack of a universal hypoxic signature, we stress the importance of deriving cell type-specific hypoxic signatures using carefully-executed experiments.

Nf1 Loss In Estrogen Receptor-Positive Breast Cancer Induces Osteoclast Formation And Immunosuppression To Promote Bone Metastasis, Matthew J Baik, Yi-Hsuan Wu, Lauren K Somes, Andres F Mosquera Paternina, Omar A Harb, Owen A Chang, Fengshuo Liu, Matthew V Holt, Junkai Wang, Igor Bado, Hai Wang, George Miles, Zbigniew Gugala, Meenakshi Anurag, Ahmed Elkhanany, Yi Li, Valentina Hoyos, Xiang H-F Zhang, Eric C Chang

Faculty, Staff and Students Publications

Estrogen receptor-positive (ER+) breast cancer exhibits a marked propensity for skeletal metastasis; however, the molecular drivers of bone colonization remain incompletely defined. We investigated the tumor suppressor neurofibromin (NF1), a dual repressor for RAS and ER signaling, whose inactivation promotes endocrine therapy (ET) resistance and is associated with inferior relapse-free survival. NF1 copy number loss was detected in 62% of ER+ patients who subsequently developed metastases and was associated with an increased likelihood of bone metastases at initial diagnosis. In mouse xenograft models, NF1-depleted ER+ breast cancer cells demonstrated enhanced dissemination to skeletal sites following surgical resection of primary tumors. …

Cerebellar Atrophy In Pediatric-Onset Opsoclonus-Myoclonus-Ataxia Syndrome: A Large International Cohort Study, Kumaran Deiva, Andrea Klein, Ming Lim, Thomas Rossor, Elizabeth A Sokol, Yasmin Khakoo, Nikita Malani Shukla, Timothy E Lotze, Wendy G Mitchell, Sarah Hopkins, Bo Zhang, Mark P Gorman

Faculty, Staff and Students Publications

Background and objectives: Pediatric-onset opsoclonus-myoclonus-ataxia syndrome (POOMAS) is a rare, neuroinflammatory syndrome that targets the cerebellum and can cause irreversible cerebellar structural changes, namely cerebellar atrophy. We investigated the frequency of cerebellar atrophy, as well as associated risk factors and functional outcome measures, using the largest active POOMAS registry.

Methods: This was a retrospective observational study of participants with POOMAS with disease onset from 1995 to 2025 using data from the multinational, multicenter POOMAS registry. Variables were compared between the cerebellar atrophy subgroups using the Fisher exact test or Wilcoxon rank-sum test.

Results: Of participants with follow-up imaging, cerebellar atrophy …

Longitudinal Patterns Of Fentanyl Utilisation (Medical Versus Illicit Sources) In The United States 2015-2023: A Retrospective Cohort Study, Richard D Urman, Ping Zhang

Faculty, Staff and Students Publications

Background: Over the last decade, fentanyl use in the U.S. has experienced a dramatic shift, largely driven by a rise in illicit fentanyl and its role in the opioid overdose crisis. Characterizing individual-level illicit fentanyl exposure poses significant challenges, as such use often occurs outside clinical settings and is not directly captured in clinical data, making it difficult to measure its true scale and impact.

Methods: We conducted a retrospective cohort study using Epic Cosmos, a large U.S. electronic health record dataset comprising over 300 million patients across inpatient and outpatient settings nationwide (January 1, 2015, to December 31, 2023). …

Rhino: An Integrative Multi-Omics Framework Linking Circadian Physiology To Precision Medicine, Panpan Liu, Roberto E López-Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan

Faculty, Staff and Students Publications

Circadian rhythms are involved in nearly all physiological processes, and their disruption increases disease risk. Aligning drug administration timing with the body's internal clock, known as circadian medicine, holds promise for improving treatment efficacy and safety. However, systematic strategies to identify circadian‐regulated therapeutic targets remain limited. Here, we develop RHINO (RHythmic Interacting Network for multi‐Omics), an integrative multi‐omics framework for exploring circadian regulation across diverse genetic and disease contexts, and prioritizing druggable circadian targets. Applying RHINO reveals that human genetic variation broadly shapes rhythmic gene expression, with approximately 80% of FDA‐approved drug targets exhibiting genotype‐dependent rhythmicity, thereby substantially expanding the …

Population Pharmacokinetics Of Bosutinib In Children With Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia Based On A Phase I Dose-Finding Trial (Itcc-054/Cog Aaml1921) And Pediatric Recommended Phase Ii Dosage Evaluation, Marieke Willemse, Karey Kowalski, Brian Jermain, May Garrett, Andrew Bukowinski, Carmelo Rizzari, Jessica Pollard, Laura Murillo-Sanjuán, Matthew Kutny, Sara Zarnegar-Lumley, Michele Redell, Stacy Cooper, Yves Bertrand, Arnaud Petit, Julie Krystal, Markus Metzler, Donna Lancaster, Jean-Pierre Bourquin, Jayashree Motwani, Inge M Van Der Sluis, Franco Locatelli, Michael E Roth, Nobuko Hijiya, C Michel Zwaan, Alwin D R Huitema

Faculty, Staff and Students Publications

Background and objectives: Bosutinib, an orally administered dual Src and Bcr-Abl tyrosine kinase inhibitor (TKI), is approved for the treatment of chronic phase Philadelphia chromosome-positive chronic myelogenous leukemia, newly diagnosed or resistant/intolerant to previous treatment of one or more TKIs in adults and children ≥ 1 years (by the US Food and Drug Administration) and ≥ 6 years (by the European Medicines Agency). Owing to the limitations of non-compartmental analysis in pharmacokinetic (PK) characterization, this study applies a prior population PK modeling approach to describe the pediatric PK of bosutinib on the basis of its phase I dose-finding trial and …

A Small Molecule Inhibits Ebola Virus Entry Through Glycoprotein Stabilization, Bruno La Rosa, Murugesan Palaniappan, Martin M Matzuk, Damian W Young, Hailey Turner-Hubbard, Kimberly Morsheimer, Callum Owen, Katalin Toth, Michael Cameron, Robert Davey, Srinivas Chamakuri, Peter Dosa, Fang Li

Faculty, Staff and Students Publications

Ebola virus (EBOV) causes outbreaks with high fatality rates, yet potent small-molecule inhibitors targeting EBOV glycoprotein (GP) remain limited. Here, using DNA-encoded chemical libraries, we screen 4.73 billion compounds against EBOV GP and, through stereochemical optimization, identify MWAC-3634. This compound binds GP with high affinity (Kd=40.7 nM), potently neutralizes infection (IC₅₀ = 0.65 nM), shows no detectable cytotoxicity, and exhibits favorable pharmacokinetics in mice. This potency substantially exceeds that of known small-molecule inhibitors targeting EBOV GP. Cryo-EM at 2.54 Å resolution reveals that MWAC-3634 occupies a hydrophobic cavity at the GP subunit interface and stabilizes GP, supporting an entry-blocking mechanism …

Reply, Jacqueline L. Chen, Amanda J. Lu, Rohan Verma, Li Wang, Douglas D. Koch, Allison J. Chen

Department of Medicine Faculty Papers

No abstract provided.

Lytic Reactivation Of Ebv By Hiv Proteins And Antiretroviral Therapy With The Heightened Expression Of Mef-2 Oncogenes Implicated In Aids-Related Cancer, Alesha Philip, Thomas A. Premeaux, Adhikarimayum Lakhikumar Sharma, Cabirou Mounchili Shintouo, Aykan Karabudak, Liudi Tang, Salwa Ahmed, Alekhya Rani Chunduri, Sai Chaitanya R. Gaekwar, Elias Haddad, Ryan Hoffmann, Mudit Tyagi, Pooja Jain

Department of Medicine Faculty Papers

Despite effective antiretroviral therapy (ART), people living with HIV (PLWH) remain at a higher risk of developing AIDS-related cancers. The factors attributed to this increased risk are multifactorial, including long-term ART use, prolonged exposure to soluble HIV proteins, and drugs of abuse. Epstein-Barr virus (EBV) is a common driver of many malignancies, such as Burkitt’s lymphoma and Hodgkin’s lymphoma. While ART effectively suppresses HIV replication, it is not curative and prolonged use imposes health risks, including an accelerated course of cancers. Herein, we investigated the effects of various factors that can impact EBV latency in PLWH in cooperation with cellular …

Smart Service Experience And Consumer Loyalty In Saudi Arabian Smart Hotels: The Mediating Roles Of Tourist Happiness And Value Co-Creation, Fahad M. Alhuqbani

Journal of Global Business Insights

Drawing on Cognitive-Affective System Theory (CAST), this study investigates the mediating roles of tourist happiness and willingness to co-create value in the relationship between Smart Service Experience (SSE) and loyalty among consumers of smart hotels in Saudi Arabia. Data were collected from 367 guests who had stayed in a smart hotel in Saudi Arabia within the past year and analyzed using Partial Least Squares Structural Equation Modeling. The findings reveal that SSE positively influences both tourist happiness and co-creation willingness, which in turn drive guest loyalty. Notably, the affective pathway through tourist happiness exerts a stronger effect on loyalty than …

A Game-Theoretic Approach To Customer Rating Of Hotels On Ota Platforms, George Lymperis, Lambros B. Drossos

Journal of Global Business Insights

This study develops a game-theoretic model of moral hazard in hotel–guest interactions on Online Travel Agency (OTA) platforms, addressing a question the reputation literature has largely overlooked: can customer reviews discipline hotel behavior even in genuinely one-shot transactions, where a guest and hotel never interact again? Standard repeated-game accounts of reputation rely on a shadow of the future that is absent in tourist-dependent markets dominated by one-time visitors. Drawing on principal–agent theory and community-enforcement models of reputation, we model the hotel–guest interaction as a static moral hazard game in which a neutral OTA verifies and enforces review-based penalties. Hotels choose …

Market Orientation And Strategic Performance In Global Firms: A Sequential Mediation Model Of Innovation And Supply Chain Resilience, Meisam Karami

Journal of Global Business Insights

This study examines how market orientation is associated with strategic performance in globally operating firms through the sequential mediating roles of innovation and supply chain resilience. Drawing on the Resource-Based View and Dynamic Capabilities Theory, the research proposes a capability-sequencing framework in which market orientation reflects a sensing capability, innovation represents a seizing capability, and supply chain resilience embodies a reconfiguring capability that stabilizes value creation under environmental disruption. Using cross-sectional survey data from 356 manufacturing and service firms engaged in international activities, partial least squares structural equation modeling was employed to test the hypothesized relationships. The results indicate that …

The Competence Architecture Of Nonprofit Organizations: A Conceptual Model Linking Leadership, Governance, And Human-Capital Systems To Institutional Credibility, Franklin Livingston

Journal of Global Business Insights

Nonprofit organizations are judged through the competence of visible leaders, yet organizational competence is not reducible to the capabilities of any single executive. Reviews of nonprofit capacity report inconsistent associations between organizational capacity and performance. This conceptual article proposes a theoretical explanation for that inconsistency, one that remains compatible with methodological explanations. It develops a model of nonprofit competence architecture in which competence is an output that organizational systems continuously produce, correct, retain, and make visible, not a stock organizations possess. A theory-synthesis design specifies four mechanisms: Leadership-formation systems generate managerial capability; governance systems detect and partially compensate for capability …

Motivation, Empowerment, And Entrepreneurial Intentions: A Pls-Sem Analysis Of Female Students In Algeria, Lotfi Mekhzoumi, Salima Ben Omar, Abderrazak Laouid, Sabrina Chikh-Amnache

Journal of Global Business Insights

This paper investigates the multidimensional nature of women’s empowerment and its impact on entrepreneurial intentions among female students at the University of El Oued, Algeria. It aims to clarify how motivational factors and perceived barriers interact with psychological, social, political, and economic empowerment to shape entrepreneurial aspirations in a developing economy context. A stratified sample of 353 female university students was used for quantitative research. A validated online questionnaire assessed entrepreneurial intention, motivation, empowerment, and barriers. Partial Least Squares Structural Equation Modelling (PLS-SEM) was used to test direct, indirect, and mediating effects between constructs, along with rigorous reliability and validity …

Catalytic Synthesis Of Protoberberine Alkaloids And Their Evaluation As Selective Dopamine Receptor Ligands, Ashok Reddy Gudipally

Dissertations, Theses, and Capstone Projects

Dopamine regulates motor control, cognition, reward, motivation, and neuroendocrine signaling. Disruption of dopaminergic neurotransmission is closely linked to central nervous system disorders, including Parkinson’s disease, schizophrenia, addiction, and related neuropsychiatric conditions. Because these functions are mediated by multiple dopamine receptor subtypes with distinct roles in physiology and disease, the discovery of subtype-selective ligands remains an important goal in neuropharmacology. Within this context, protoberberine alkaloids, particularly tetrahydroprotoberberines (THPBs), are attractive molecular frameworks because they combine structural complexity with broad biological relevance, including measurable activity in CNS-related diseases. Prior work from our laboratory and others established (–)-stepholidine (1.60) as an important lead …

The Impact Of Gun Control Policies On Firearm-Related Deaths: A Two Decade State-By-Year Analysis, Rabana Tajrin

Dissertations, Theses, and Capstone Projects

This report analyzed firearm-related deaths rates in the United States at the state level over a two decade period between 2000 to 2019. The study used a state-by-year analytical framework created from the U.S. Gun Deaths by County, 1999–2019 dataset (Eltom, 2019) in order to examine national trends, state-level differences, changes over time, geographic concentration, and regional variation. The analysis focused on firearm-related deaths by adjusting for population size differences (i.e., the crude firearm-related death rate) across U.S. states from 2000 to 2019. These analyses indicated that firearm-related deaths increased nationally during the study period. Total firearm-related deaths rose from …

Bridging Data Gaps In Retinal Imaging: From Structural Domain Adaptation To Topology-Aware Synthesis, Gözde Merve Demirci

Dissertations, Theses, and Capstone Projects

Comprehensive visualization of the retina is essential for diagnosing and monitoring blinding diseases such as Diabetic Retinopathy and Retinopathy of Prematurity (ROP), where pathological changes often extend beyond a single field of view. Despite significant advances in automated retinal image analysis, clinical deployment remains limited by two fundamental data gaps: a structural learning gap, arising from scarce expert annotations and poor generalization across imaging domains, and a spatial coverage gap, caused by the difficulty of acquiring multi-view retinal images in fragile populations. Although these challenges are often addressed independently, this dissertation argues that they are tightly coupled: accurate, …

Cognitive-Affective And Somatic Depressive Symptom Domains Related To Psychological Mechanisms And Sociodemographic Factors, Danielle B. Hazeltine

Dissertations, Theses, and Capstone Projects

Major depressive disorder is prevalent, chronic, and heterogeneous, including cognitive- affective (e.g., maladaptive beliefs or thinking patterns and sad mood) and somatic (e.g., fatigue, appetite, or sleep changes) symptom domains. While depression domains have been long theorized, research examining psychological mechanisms underlying this distinction is limited. Preliminary research suggests cognitive-affective symptoms relate more strongly to cognitive mechanisms (cognitive bias, perseverative thought), somatic symptoms relate more strongly to behavioral mechanisms (behavioral inhibition/activation), and gender, race, and ethnicity moderate these relationships. This study examined whether cognitive-affective and somatic symptom domains differentially relate to cognitive and behavioral mechanisms, and whether these relationships are …

Alzheimer’S Disease And Related Dementias Risk Profiles And Health Literacy Among South Asian Seniors, Sandra A. Kennedy

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease and Related Dementias (ADRD) pose significant health challenges globally, with South Asian seniors in the United States facing elevated risks due to high rates of cardiovascular disease, diabetes, and limited health literacy. This study assessed dementia literacy and the prevalence of cardiovascular, psychosocial, and lifestyle risk factors among South Asian seniors in New York City, utilizing community-based participatory research (CBPR) principles in collaboration with India Home, a community-based organization. Fifty-six (N=56) South Asian seniors aged 55 and older (M = 69.05, SD = 6.36), primarily of Indian or Bangladeshi origin, participated in the study. Data collection involved a …

Authoritarianism, Hostility And Threat: An Analysis Of American Political Podcasts Surrounding The 2024 Presidential Election, Noah D. Cohen

Dissertations, Theses, and Capstone Projects

Political rhetoric surrounding key events has seen sharp increases in emotionally affective speech, intergroup sentiment, and rhetoric unbecoming of democratic societies in recent years. Similarly, semi-democratic and ideologically driven speech has become increasingly normalized within an era of political polarization and hardline beliefs in modern media. Within this economy of outrage, sensational and largely unmoderated media formats, particularly podcasts, have become a mainstay of political information and discourse. This raises an important question: how does rhetoric surrounding political events construct intergroup sentiment and authoritarian rhetoric within political media, particularly American political podcasts? Further, given political podcasts’ growing social influence in …

Distinguishing Between Complex Post-Traumatic Stress Disorder And Post-Traumatic Stress Disorder: The Role Of Childhood Maltreatment, Catherine Harris

Dissertations, Theses, and Capstone Projects

The current study examined whether court-substantiated childhood maltreatment may be associated with increased risk for Complex PTSD (CPTSD) and whether individuals with CPTSD and individuals with PTSD could be distinguished in terms of complex trauma exposure. Children with documented cases of abuse and neglect prior to age 11 were matched on age, race, sex, and approximate family socioeconomic status with children without documented histories of maltreatment (controls) and both groups were followed prospectively into adulthood. Participants (N = 1,196) were assessed using a DSM-III-R based structured interview of PTSD symptoms and other self-report measures of psychiatric symptoms at mean age …

Intimate Partner Violence And Emotion Regulation Among Emerging Adults: Investigating The Roles Of Dispositional Mindfulness And Executive Function In The Context Of A Laboratory-Induced Stress Paradigm, Mikell Bursky

Dissertations, Theses, and Capstone Projects

Intimate Partner Violence (IPV) is a major public health concern that impacts an estimated 10 million men and women in the United States annually. IPV refers to a range of physical, sexual or psychological forms of aggression committed against a current or former romantic partner in the context of a relationship. The highest rates of IPV are observed in emerging adulthood, a developmental period between the ages of 18 to 25 that is significant for the transition from adolescence into adulthood, and the establishment of first meaningful intimate relationships. Although distal risk factors for IPV such as violence in the …

The Cranial Nerves And Electrical Stimulation, Devin K. P. Adair

Dissertations, Theses, and Capstone Projects

Cranial nerves provide afferent pathways that enable bottom-up modulation of central autonomic and cognitive neural pathways. Because these pathways project to brainstem nuclei such as the nucleus tractus solitarius and engage neuromodulatory systems, including the locus coeruleus, electrical stimulation offers a mechanistically grounded approach to influencing brain function. This thesis tested whether active transcutaneous auricular vagus nerve stimulation (taVNS) produces physiological responses indicative of parasympathetic engagement, defined as decreases in heart rate, increases in heart rate variability, and decreases in respiration relative to a dose-matched earlobe control condition. Using cardiac and respiratory measures as physiological markers, taVNS at the tragus …

Model-Theoretic Arguments In Philosophy, Peter Susanszky

Dissertations, Theses, and Capstone Projects

This dissertation is on model-theoretic arguments in philosophy, especially those of Quine, Davidson, and Putnam. In the first part, to ground the debate, I give a rigorous introduction to the salient parts of first-order model theory. I start the second part by giving an introduction to Quine's philosophy, and how the model-theoretic arguments fit into it. After considering how Donald Davidson adopted the Quinean lesson, I move on to Putnam's model-theoretic arguments. Putnam's spin on these model-theoretic considerations significantly departs from Quine and Davidson, while retaining many of the core ideas. Most importantly, I argue that the target of Putnam's …

Teaching Third Graders To Read Multisyllable Words: Segmentation Versus Whole Word Reading, Jolie D. Heath

Dissertations, Theses, and Capstone Projects

In the early years of elementary school when children are still learning to read, they are presented with words of increased syllable length, and orthographic and morphological complexity in the texts they read.  Although multisyllabic words comprise 90% of words in the English lexicon and carry important linguistic information for expanding vocabularies and comprehension of content, few studies have focused on teaching middle elementary children to read multisyllabic words.  Many children lack strategies to identify these longer more complex words accurately and easily, leading to reading difficulties that place weaker readers at higher risk for school related problems and limit …