Digital Commons Network^™

Comparing The Differences Of Hsp90Α And Hsp90Β In Native Protein Complex Incorporation, Daryna Serediuk

Honors Theses and Capstones

Epichaperomes are long-lasting, stable assemblies of chaperones, co-chaperones, and associated factors that facilitate cell survival in maladaptive cellular states. Their inhibition has emerged as an attractive therapeutic strategy for the treatment of cancer and neurodegenerative diseases (Rodina et al., 2016). Epichaperomes are hallmarks of robust proliferation in cancer cell populations across many cancer types and are abundantly present in several stem cell varieties, including induced pluripotent stem cells, human embryonic kidney cells, and cancer stem cells (Kishinevsky et al., 2018).

The core protein of the eukaryotic heat shock protein machinery, Heat Shock Protein 90 (Hsp90), is a central chaperone that …

Restoring Tidal Function: Hydrologic And Erosion Controls, On Rare Plant Distribution In New Hampshire Salt Marshes, Nikhila B. Lampman

Honors Theses and Capstones

No abstract provided.

Exploring The Association Between Internal Body Temperature And Metabolic Status In Early Lactation Jersey Cattle, Alexandra Ferreri, Claira Seely

Honors Theses and Capstones

No abstract provided.

Differential Effects Of Growing-Season Climate Anomalies On New England Crop Yields: A 1990-2024 Comparative Analysis Of Heat-Tolerant And Heat-Sensitive Crops, Rhea Shirodkar

Honors Theses and Capstones

As rising temperatures and variable precipitation effects are becoming increasingly prevalent in New England, as does the need to consider how these climate change-induced weather patterns affect the region's agricultural productivity and food system stability. Using annual crop yield data from the United States Department of Agriculture’s National Agricultural Statistics Service (USDA NASS) and growing-season climate anomaly data from NOAA’s National Centers for Environmental Information (NCEI), this study examines how growing-season temperature and precipitation anomalies affect seven major New England crop yields (tomatoes, potatoes, sweet corn, cranberries, carrots, lettuce (head), and apples) over a 34-year period from 1990 to 2024. …

Taboo And Innuendos: A Conversation Analysis Of Dirty Jokes, Bailey Fraser

Honors Theses and Capstones

No abstract provided.

Effects Of Volatile Organic Compounds Produced By Temperature-Adapted Microbes On Duckweed Growth, Phaedra Yael Stemp

Honors Theses and Capstones

As host-associated microbes adapt to their abiotic environment, these adaptations can affect their host species as well. Previous research showed that varying temperatures and volatile organic compound (VOC) production can affect microbial benefits to hosts. This experiment analyzed how 27 microbes pre-adapted to different temperature conditions affected growth of their host, common duckweed plants, comparing effects of direct contact with microbes, effects of microbe VOCs alone, or both. Each microbe was pre-adapted to one of three temperature regimes: “Northern” at 28 °C, “Southern” at 33 °C, and “Extreme” at 36 °C. We then grew duckweeds in I-plates with each microbe …

Fgf Signaling Is Necessary For Newt Lens Regeneration, Leo Alexander Napoleon

Honors Theses and Capstones

The Iberian ribbed newt Pleurodeles waltl can regenerate the lens by transdifferentiating iris pigmented epithelial (IPE) cells into lens epithelial cells (LECs), but the mechanism by which this occurs remains largely uncharacterized. We aim to mechanistically show an early and critical role for FGF signaling by using small molecules to inhibit FGF receptors and observe the histological and intracellular effects. Two inhibitors were found to completely stall lens regeneration. Cell cycle analysis revealed decreased DNA synthesis and uniformly low but unchanged entry to mitosis under signaling inhibition by staining for EdU incorporation and phospho-histone H3 (pH3), respectively. Western blot revealed …

Preserved Artificial Grammar Learning In Individuals With Parkinson’S Disease: A Systematic Review, Sarah I. Cranna

Honors Theses and Capstones

Abstract

            Implicit statistical learning is a crucial cognitive function that is highly involved in the learning and processing of language. Since both language and implicit statistical learning are supported by the basal ganglia through cortico-striatal networks, disruptions to this network could result in their impairment. Parkinson’s Disease (PD) can therefore be used to model disruptions to this system as it is primarily characterized by dysfunction in the basal ganglia. Thus, this review aims to examine the current literature studying the performance of individuals with PD on artificial grammar tasks in order to investigate the impact of impaired basal ganglia function …

Tmem116 Crispr-Mediated Knockout Prevents Proper Lens Regeneration In Iberian-Ribbed Newts, Damien T. Mann

Honors Theses and Capstones

Eye diseases like cataracts, age-related macular degeneration (AMD), and glaucoma are widespread and detrimental conditions affecting many people across the globe. While there are reliable and successful treatments for those with cataracts that can reverse vision impediments, others like glaucoma and AMD have limited treatment options. Additionally, eye damage resulting from these conditions is commonly irreversible, establishing a need for new treatment options. The Iberian-ribbed newt, Pleurodeles waltl, is a salamander species primarily studied for their amazing regenerative capabilities. Particularly, these newts are capable of de novo lens regeneration after a complete resection, providing a unique opportunity to study regeneration …

Investigating Microbe-Mediated Temperature Tolerance In Lemna Minor, Matthew Thomas Farbaniec

Honors Theses and Capstones

Temperature limits plant growth and survival more than many other environmental variables, and increases in the frequency of extreme hot or cold weather events pose significant challenges for plant growth and crop yields. Previous studies have shown that bacteria, fungi, and other microorganisms associated with plants ( i.e., the plant microbiome) can influence host response to temperature stress. These same microbes have their own temperature tolerances. We investigated whether microbial temperature tolerance correlates with plant resilience using an aquatic plant model, Lemna minor, and isolates derived from its microbiome. Microbial isolates were assessed at −10°C, 4°C, and 32°C for …

Detection And Management Of Attacks On Synchronized Networks, Michael T. Spearman

Honors Theses and Capstones

The Precision Time Protocol (IEEE 1588) provides sub-microsecond clock synchronization across packet-switched networks and has become foundational infrastructure in 5G fronthaul, industrial control systems, and financial exchanges. Despite its criticality, most deployed PTP networks operate without active security monitoring, and no standardized detection mechanism exists for the class of attacks that deliberately stay below conventional jitter thresholds. This thesis investigates whether hardware-level ptp4l offset logs alone are sufficient to reliably detect two such attacks, slowly wandering packet delay injection and rogue master spoofing, and whether detection can occur before severe synchronization failure.

A hardware-in-the-loop testbed was constructed using two hosts …

Stress And Reward Interactions In Substance Use Disorder: An Evolutionary Mismatch Framework, Nicholas L. Castrucci

Honors Theses and Capstones

Substance use disorder (SUD) is a major public health concern characterized by compulsive substance use despite adverse consequences. While contemporary models emphasize biological, psychological, and environmental contributors, stress- and reward-related systems are often examined in isolation. This review integrates these systems within an evolutionary mismatch framework to examine how chronic stress exposure and repeated substance use increase vulnerability to addiction. Stress and reward systems are evolutionarily conserved but may become chronically dysregulated under modern conditions characterized by persistent psychosocial stressors and highly potent rewarding stimuli. This is associated with converging neuroadaptations across stress and reward circuitry, resulting in altered affective …

Examining The Effectiveness Of Housing First Models On Transitional-Aged Youth Experiencing Homelessness: A Systematized Review, Cadyn Golisano

Honors Theses and Capstones

Abstract

Purpose: The purpose of this review is to examine the outcomes of Housing First (HF) programs or models for transitional-age youth (TAY) experiencing homelessness. Specifically, this review aims to synthesize existing evidence on how Housing First influences housing stability and over-all wellbeing for young adults ages 18-25. By evaluating the effectiveness of these programs within this specific population, the review seeks to identify key benefits, limitations, and gaps in the current literature to inform future practice, policy, and research. The following research question was utilized to guide this paper: How do Housing First principals and interventions impact housing stability …

Reading Between The Lines: Representations Of Dyslexia In Young Adult Literature, Carli B. Gauvin

Honors Theses and Capstones

While dyslexia affects upwards of 20% of the population, this learning disability is not commonly brought up in young adult literature. This lack of representation negatively impacts those with dyslexia, who often fail to find themselves in the books they read, and readers in general, who are given fewer opportunities to gain insight into the learning disability. Young adult books that do discuss dyslexia can be at risk of portraying the learning disability in an unfavorable light, which can make dyslexic readers feel undervalued in society and can introduce misconceptions about dyslexia to all readers. It is crucial to analyze …

Phonetics And Orthography In French: A Proposal For A New Course, Kyara A. Crespo Gutierrez

Honors Theses and Capstones

No abstract provided.

Investigating A Nanoparticle-Assisted Approach For Localized Strain Engineering In Two-Dimensional Materials, Skye Martichuski

Honors Theses and Capstones

This work investigated a fabrication strategy for inducing localized nanoscale deformation and strain in transferred MoS2 flakes using gold nanoparticle-coated substrates as a potential platform for strain engineering in two-dimensional materials. Substrate type, nanoparticle concentration, drying conditions, cleaning procedures, and flake transfer methods were investigated using optical microscopy and atomic force microscopy (AFM). Au-coated SiO2 substrates produced improved nanoparticle coverage compared to bare SiO2, while passive air drying yielded the most favorable nanoparticle distributions. Salt crystals introduced during passive drying were successfully removed with a gentle deionized water rinse, and a 50% diluted gold nanoparticle suspension provided improved particle spacing …

Embracing Anomalous Perceptions: Sensory Anomalies, Social Stigma, And Self-Acceptance, Ty R. Hetrick

Honors Theses and Capstones

Anomalous Perceptual Experiences (APEs), which include auditory and visual hallucinations, occur in the general population to varying degrees, but are often stigmatized in media and healthcare settings. However, there is an increasing focus on those who report APEs to be positive and meaningful. This study explored the lived experiences of individuals who report APEs that are interpreted meaningfully. Using a concurrent mixed methods approach, interviews and questionnaires were conducted with 3 adults who identify their APEs as meaningful. Participants described their experiences as sources of guidance, connection, and personal transformation that positively influenced their relationships, spirituality, and daily occupations. They …

Driving Monitoring Of People With Alzheimer’S Disease And Related Dementia Using Global Positioning System Technology, Julia A. Ferris

Honors Theses and Capstones

No abstract provided.

Review Of Hayek's Bastards: The Neoliberal Roots Of The Populist Right, Michael Kirby

Publications and Research

No abstract provided.

The Paradox Of Matriliny: Cultural Authority And The Political Marginalization Of Women In Meghalaya, Kasturi Bharadwaj

Journal of International Women's Studies

The global discourse on gender equality gained momentum after the 1975 United Nations World Conference on Women. It continued through a series of international initiatives and culminated in the Beijing Declaration and Platform for Action, which emphasized women’s rights and their participation in political, social, and economic life. Despite these normative commitments at the international level, women’s political participation and representation within administrative and decision-making structures continue to be uneven, limited, and structurally constrained across many societies. In this context, the study investigates the political participation and representation of women in Meghalaya, a tribal state in Northeast India characterized by …

Mary Cole Nibarger Wts Collection - Accession 1855, Mary Cole Parks Nibarger

Manuscript Collection

The Mary Cole Nibarger Collection consists of materials documenting Mrs. Mary Cole Parks Nibarger’s (1930-2021) teaching experience at the Winthrop Training School. Mrs. Nibarger was a 1951 Winthrop College graduate and was employed with the Winthrop Training School from September 1955 until its close in 1965. She served in many capacities including Supervisor of Mathematics and Freshman Class Sponsor. The collection reflects her commitment to education and dedication to the Winthrop Training School.

The collection includes yearbooks, class reunion correspondence, photographs, newspaper clippings, and miscellaneous items. The yearbooks document the students of WTS in the years 1956-1958, 1960, and 1962-1965. …

07.02.01. Limpkin, Aramus Guarauna, D. C. Bryan, Ann Hodgson, Florida Ornithological Society

07.02. <em>Aramidae</em> - Limpkin

The Limpkin is an iconic Florida wading bird known for its specialized foraging on the native Florida apple snail.

07.01.05. Purple Gallinule, Porphyrio Martinica, Bill Pranty, Ann Hodgson, Florida Ornithological Society

07.01. <em>Rallidae</em> - Rails, Gallinules, and Coots

A colorful and acrobatic rail, the Purple Gallinule breeds from Arkansas and South Carolina south through the Greater Antilles and Middle America to northern Argentina and Bolivia.

Submicron Diamond-Assisted Irrigation Enhances Apical Biofilm Removal Under Sonic And Ultrasonic Activation: An Ex Vivo Study, Yung-Szu Hsu, Nai-Chia Teng, Sin-Yu Chen, Huan-Cheng Chang, Haw-Ming Huang, Sung-Chih Hsieh

Journal of Dental Sciences

Background/purpose:

Residual apical biofilm often persists despite sodium hypochlorite (NaOCl) irrigation with sonic or ultrasonic activation. Submicron diamond particles (SMD) have shown promise as a particle-assisted adjunct for root canal cleaning, but their effects on mature intracanal biofilm remain unclear. This study evaluated whether 500-nm SMD particles (10 mg/mL) improve the antibacterial and antibiofilm efficacy of saline or NaOCl irrigation against mature Enterococcus faecalis (E. faecalis) biofilms.

Materials and methods:

One hundred single-rooted human premolars infected with E. faecalis for 21 days were randomly allocated to ten irrigation protocols (n = 10). Antibacterial efficacy was assessed by …

Exosomes Derived From Bone Substitute-Induced Gingival Mesenchymal Stem Cells Promote Angiogenesis, Chongyu Shen, Zheng Guan, Rui Chu, Zhengyin Li, Jiangting Lu, Liangkun Xie

Journal of Dental Sciences

Background/purpose: In certain clinical bone grafting scenarios, bone substitutes frequently interface with the adjacent soft tissues. This study aimed to investigate whether deproteinized bovine bone mineral (DBBM) and coralline hydroxyapatite (CHA) induce paracrine responses in human gingival mesenchymal stem cells (GMSCs), thereby altering the pro-angiogenic capacity of their derived exosomes, and to profile specific cargo alterations.

Materials and methods: Exosomes were isolated from GMSCs co-cultured with DBBM (DBBM-G-EXO) or CHA (CHA-G-EXO), while native GMSCs-derived exosomes (G-EXO) were collected as controls. The angiogenic effects of these exosomes on human umbilical vein endothelial cells (HUVEC) were evaluated via cell proliferation, scratch wound …

Silencing The Mir-132/Sirt1 Axis Suppresses Nlrp3 Inflammasome Activation And Myofibroblast Differentiation In Oral Submucous Fibrosis, Ming-Yung Chou, Min Yee Ng, Yi-Wen Liao, Chuan-Hang Yu, Cheng-Chia Yu, Sin-Jia Tseng

Journal of Dental Sciences

Background/purpose

Oral submucous fibrosis (OSF) is a chronic oral potentially malignant disorder characterized by progressive extracellular matrix deposition, myofibroblast activation, oxidative stress, and inflammatory signaling. However, the upstream microRNA-mediated mechanisms linking fibrogenesis and NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome activation remain unclear. This study investigated the role of the miR-132/sirtuin 1  (SIRT1) axis in OSF-associated fibrotic and inflammatory responses.

Materials and methods

miR-132 expression was examined in OSF tissues, normal tissues, primary buccal mucosal fibroblasts (BMFs), and fibrotic buccal mucosal fibroblasts (fBMFs) using RNA sequencing and quantitative real-time PCR. Patient-derived fBMFs were transfected with a miR-132 inhibitor …

A Scientometric Study On Research Trends And Characteristics Of Kimura Disease, Zhongjing Lv, Yiming Luo, Wei Liu, Jian Yuan

Journal of Dental Sciences

Background/purpose: Kimura disease (KD) is an idiopathic condition that presents as a chronic, benign inflammatory disorder, typically affecting the head and neck region. The purpose of this study was to analyze the scientometric characteristics and research trends of KD.

Materials and methods: All the papers on KD were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2012 and after 2012 in the analysis of research trends.

Results: There were 925 papers on KD, with total citations of 10,821 and the h index of 47. Eosinophilia, lymphadenopathy, nephrotic syndrome, angiofollicular lymph node hyperplasia, …

Anemia, Hematinic Deficiencies, And Gastric Parietal Cell Antibody Positivity In Recurrent Aphthous Stomatitis Patients With Or Without Hyperhomocysteinemia, Yi-Ping Wang, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous study found that 42 of 430 recurrent aphthous stomatitis (RAS) patients have hyperhomocysteinemia. This study assessed whether these 42 RAS patients with hyperhomocysteinemia (hyperhomocysteinemia/RAS patients) had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 388 RAS patients without hyperhomocysteinemia (non-hyperhomocysteinemia/RAS patients) or 430 healthy control subjects.

Materials and methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 42 hyperhomocysteinemia/RAS patients, 388 non-hyperhomocysteinemia/RAS patients, and 430 healthy control subjects were measured and compared.

Results: We found that 42 hyperhomocysteinemia/RAS patients had significantly …

Very Early Interceptive Management Of Class Iii Malocclusion In Primary Dentition Using A Prefabricated Functional Education Appliance: Preliminary Clinical Observations, Thi Ngoc Anh Do, Thi Huong Le, I-Ta Lee, Tong-Hsien Chow, Pao-Chang Chiang, Thi Thuy Tien Vo

Journal of Dental Sciences

Background/purpose: Class III malocclusion with anterior crossbite in primary dentition may progress and complicate future orthodontic treatment. This short communication presents preliminary clinical observations of very early interception using a prefabricated functional education appliance.

Materials and methods: Three children aged 4 to 6 years with dental, functional, or mild skeletal class III malocclusion were treated using a prefabricated removable functional education appliance worn at night, with regular follow-up.

Results: In the dental class III case, anterior crossbite was corrected within 9 months and remained stable at the 2-year follow-up. In the functional class III case, anterior crossbite and mandibular shift …

Artificial Intelligence In Dentistry: A Cross-Domain Bibliometric Analysis Of Technologies, Functional Applications, And Dental Specialties, Yinghui Yang, Cheng-Chia Yu, Min Yee Ng

Journal of Dental Sciences

Background/purpose: Artificial intelligence is increasingly applied in dentistry across diagnosis, prediction, treatment planning, education, and patient communication. This study aimed to provide a structured cross-domain overview of dental AI research by integrating AI technologies, functional applications, and dental specialties within one bibliometric framework.

Materials and methods: AI-related dental publications from 2016 to 2026 were retrieved from the Web of Science Core Collection. Original and review articles were screened and classified by AI technology, functional application, and dental specialty. Bibliometric mapping, collaboration analysis, keyword co-occurrence, and heatmap-based cross-domain visualization were performed.

Results: A total of 920 publications were included. Publication …